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Tytuł :
Inhibiting neuraminidase can make the difference.
Autorzy :
Rappuoli R; GlaxoSmithKline, Siena, Italy .; Department of Medicine, Imperial College London, London, UK.
Del Giudice G; GlaxoSmithKline, Siena, Italy.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2019 Feb 04; Vol. 216 (2), pp. 251-252. Date of Electronic Publication: 2019 Jan 25.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Influenza Vaccines*
Influenza A virus/*immunology
Antibodies, Neutralizing ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Hemagglutinins ; Neuraminidase
Czasopismo naukowe
Tytuł :
Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59®-adjuvanted pandemic 2009 H1N1 vaccine.
Autorzy :
Ferdman J; Seqirus, Inc. (formerly Novartis Influenza Vaccines), Cambridge, MA 02139, USA. Electronic address: .
Palladino G; Seqirus, Inc. (formerly Novartis Influenza Vaccines), Cambridge, MA 02139, USA. Electronic address: giuseppe..
Liao HX; Duke Human Vaccine Institute, Duke University Medical School, Durham, NC 27710, USA. Electronic address: .
Moody MA; Duke Human Vaccine Institute, Duke University Medical School, Durham, NC 27710, USA. Electronic address: .
Kepler TB; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: .
Del Giudice G; GSK Vaccines (formerly Novartis Vaccines and Diagnostics), Siena 53100, Italy. Electronic address: giuseppe.x.del-giudice@gsk.com.
Dormitzer PR; Seqirus, Inc. (formerly Novartis Influenza Vaccines), Cambridge, MA 02139, USA. Electronic address: .
Harrison SC; Laboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA. Electronic address: .
Settembre EC; Seqirus, Inc. (formerly Novartis Influenza Vaccines), Cambridge, MA 02139, USA. Electronic address: .
Suphaphiphat P; Seqirus, Inc. (formerly Novartis Influenza Vaccines), Cambridge, MA 02139, USA. Electronic address: .
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Źródło :
Vaccine [Vaccine] 2018 Aug 23; Vol. 36 (35), pp. 5325-5332. Date of Electronic Publication: 2018 Jul 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Influenza A Virus, H1N1 Subtype/*pathogenicity
Influenza Vaccines/*chemistry
Influenza Vaccines/*immunology
Vaccination/*methods
Adjuvants, Immunologic/therapeutic use ; Animals ; Antibodies, Neutralizing/immunology ; Hemagglutination Inhibition Tests ; Humans ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza Vaccines/therapeutic use ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Polysorbates/chemistry ; Seasons ; Squalene/chemistry ; Swine
Czasopismo naukowe
Tytuł :
Short-term and mid-term solutions for influenza vaccines.
Autorzy :
Hanon E; GlaxoSmithKline, Rixensart, Belgium.
Van der Most R; GlaxoSmithKline, Rixensart, Belgium.
Del Giudice G; GlaxoSmithKline, Siena, Italy.
Rappuoli R; GlaxoSmithKline, Siena, Italy. Electronic address: .
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Źródło :
The Lancet. Infectious diseases [Lancet Infect Dis] 2018 Aug; Vol. 18 (8), pp. 832-833.
Typ publikacji :
Letter
MeSH Terms :
Vaccines, Inactivated*/immunology
Influenza Vaccines/*administration & dosage
Influenza, Human/*prevention & control
Drug Development/methods ; Humans ; Influenza Vaccines/immunology
Opinia redakcyjna
Tytuł :
Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain.
Autorzy :
Raymond DD; Laboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School.
Stewart SM; Seqirus, 45 Sidney St., Cambridge, Massachusetts, USA.
Lee J; Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, USA.
Ferdman J; Seqirus, 45 Sidney St., Cambridge, Massachusetts, USA.
Bajic G; Laboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School.
Do KT; Laboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School.
Ernandes MJ; Laboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School.; Graduate Program in Virology, Harvard Medical School, Boston, Massachusetts, USA.
Suphaphiphat P; Seqirus, 45 Sidney St., Cambridge, Massachusetts, USA.
Settembre EC; Seqirus, 45 Sidney St., Cambridge, Massachusetts, USA.
Dormitzer PR; Seqirus, 45 Sidney St., Cambridge, Massachusetts, USA.
Del Giudice G; Novartis Vaccines and Diagnostics, Siena, Italy.
Finco O; Novartis Vaccines and Diagnostics, Siena, Italy.
Kang TH; Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, USA.
Ippolito GC; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA.
Georgiou G; Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, USA.; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA.; Center of Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, USA.; Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas, USA.
Kepler TB; Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA.
Haynes BF; Duke Human Vaccine Institute, Duke University Medical School, Durham, North Carolina, USA.; Department of Medicine, Duke University Medical School, Durham, North Carolina, USA.
Moody MA; Duke Human Vaccine Institute, Duke University Medical School, Durham, North Carolina, USA.; Department of Pediatrics, Duke University Medical School, Durham, North Carolina, USA.
Liao HX; Duke Human Vaccine Institute, Duke University Medical School, Durham, North Carolina, USA.; Department of Medicine, Duke University Medical School, Durham, North Carolina, USA.
Schmidt AG; Laboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School.
Harrison SC; Laboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School.; Howard Hughes Medical Institute, Boston, Massachusetts, USA.
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Źródło :
Nature medicine [Nat Med] 2016 Dec; Vol. 22 (12), pp. 1465-1469. Date of Electronic Publication: 2016 Nov 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Hemagglutinin Glycoproteins, Influenza Virus/*immunology
Influenza A Virus, H1N1 Subtype/*immunology
Influenza Vaccines/*immunology
Influenza, Human/*prevention & control
Sialic Acids/*immunology
Animals ; Chickens ; Crystallization ; Dogs ; Eggs ; Humans ; Immunogenicity, Vaccine/immunology ; Influenza in Birds/virology ; Influenza, Human/virology ; Madin Darby Canine Kidney Cells ; Plasma Cells/immunology ; Protein Structure, Tertiary
Czasopismo naukowe
Tytuł :
Influence of Statins on Influenza Vaccine Response in Elderly Individuals.
Autorzy :
Black S; Center for Global Health, Cincinnati Children's Hospital, Ohio.
Nicolay U; Novartis Vaccines, Marburg, Germany.
Del Giudice G; Novartis Vaccines, Siena, Italy.
Rappuoli R; Novartis Vaccines, Siena, Italy.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2016 Apr 15; Vol. 213 (8), pp. 1224-8. Date of Electronic Publication: 2015 Oct 28.
Typ publikacji :
Journal Article; Observational Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects
Influenza Vaccines/*immunology
Aged ; Antibodies, Viral/blood ; Cross-Sectional Studies ; Drug Interactions ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Influenza Vaccines/administration & dosage ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.
Autorzy :
Nakaya HI; Department of Pathophysiology and Toxicology, School of Pharmaceutical Sciences, University of São Paulo, 05508, São Paulo, Brazil; Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322;
Clutterbuck E; Oxford Vaccine Group, Department of Pediatrics, University of Oxford and the National Institute for Health Research Oxford Biomedical Research Centre, Oxford OX3 9DU, United Kingdom;
Kazmin D; Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30329;
Wang L; Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom;
Cortese M; Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30329;
Bosinger SE; Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30329; Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30322;
Patel NB; Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30322;
Zak DE; Center for Infectious Disease Research, Seattle, WA 98109;
Aderem A; Center for Infectious Disease Research, Seattle, WA 98109;
Dong T; Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom;
Del Giudice G; Research Center, Novartis Vaccines, 53100 Siena, Italy;
Rappuoli R; Research Center, Novartis Vaccines, 53100 Siena, Italy; .
Cerundolo V; Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom;
Pollard AJ; Oxford Vaccine Group, Department of Pediatrics, University of Oxford and the National Institute for Health Research Oxford Biomedical Research Centre, Oxford OX3 9DU, United Kingdom;
Pulendran B; Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322; Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30329; .
Siegrist CA; WHO Collaborative Center for Vaccine Immunology, Departments of Pathology-Immunology and Pediatrics, University of Geneva, 1211 Geneva, Switzerland .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Feb 16; Vol. 113 (7), pp. 1853-8. Date of Electronic Publication: 2016 Jan 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Systems Biology*
Adjuvants, Immunologic/*administration & dosage
Influenza Vaccines/*administration & dosage
Polysorbates/*administration & dosage
Squalene/*administration & dosage
Antibodies, Viral/biosynthesis ; B-Lymphocytes/immunology ; Humans ; Immunologic Memory ; Infant ; Influenza Vaccines/immunology ; Transcriptome
Czasopismo naukowe
Tytuł :
MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life.
Autorzy :
Mastelic Gavillet B; Department of Pathology-Immunology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CH-1211 Geneva 4, Switzerland;
Eberhardt CS; Department of Pathology-Immunology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CH-1211 Geneva 4, Switzerland;
Auderset F; Department of Pathology-Immunology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CH-1211 Geneva 4, Switzerland;
Castellino F; Novartis Vaccines and Diagnostics, 53100 Siena, Italy; and.
Seubert A; Novartis Vaccines and Diagnostics, 53100 Siena, Italy; and.
Tregoning JS; Mucosal Infection and Immunity Group, Section of Virology, St. Mary's Campus, Imperial College London, London W2 1PG, United Kingdom.
Lambert PH; Department of Pathology-Immunology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CH-1211 Geneva 4, Switzerland;
de Gregorio E; Novartis Vaccines and Diagnostics, 53100 Siena, Italy; and.
Del Giudice G; Novartis Vaccines and Diagnostics, 53100 Siena, Italy; and.
Siegrist CA; Department of Pathology-Immunology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CH-1211 Geneva 4, Switzerland; .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2015 May 15; Vol. 194 (10), pp. 4836-45. Date of Electronic Publication: 2015 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adjuvants, Immunologic/*pharmacology
Influenza Vaccines/*immunology
Polysorbates/*pharmacology
Squalene/*pharmacology
T-Lymphocytes, Helper-Inducer/*immunology
Animals ; Animals, Newborn ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Germinal Center/immunology ; Immunohistochemistry ; Influenza A Virus, H1N1 Subtype/immunology ; Mice ; Real-Time Polymerase Chain Reaction ; Squalene/immunology
Czasopismo naukowe
Tytuł :
Inactivated and adjuvanted influenza vaccines.
Autorzy :
Del Giudice G; Research and Development, Novartis Vaccines, Via Fiorentina 1, 53100, Siena, Italy, giuseppe..
Rappuoli R
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Źródło :
Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2015; Vol. 386, pp. 151-80.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Influenza Vaccines/*immunology
Adjuvants, Immunologic/pharmacology ; Animals ; Drug Combinations ; Humans ; Polysorbates/pharmacology ; Squalene/pharmacology ; Vaccines, Inactivated/immunology ; alpha-Tocopherol/pharmacology
Czasopismo naukowe
Tytuł :
Dissecting the immune response to MF59-adjuvanted and nonadjuvanted seasonal influenza vaccines in children less than three years of age.
Autorzy :
Zedda L; From the *Novartis Vaccines, Siena, Italy and Cambridge, MA; †Sint Vincentius Ziekenhuis, Antwerp, Belgium; ‡Kinderartsenassociatie, Hasselt, Belgium; §ImmuneHealth, Charleroi, Belgium; and ¶Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium.
Forleo-Neto E
Vertruyen A
Raes M
Marchant A
Jansen W
Clouting H
Arora A
Beatty ME
Galli G
Del Giudice G
Castellino F
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Źródło :
The Pediatric infectious disease journal [Pediatr Infect Dis J] 2015 Jan; Vol. 34 (1), pp. 73-8.
Typ publikacji :
Clinical Trial, Phase II; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Adjuvants, Immunologic/*administration & dosage
Antibodies, Viral/*blood
CD4-Positive T-Lymphocytes/*immunology
Influenza Vaccines/*administration & dosage
Influenza Vaccines/*immunology
Polysorbates/*administration & dosage
Squalene/*administration & dosage
Child, Preschool ; Female ; Hemagglutination Inhibition Tests ; Humans ; Infant ; Interleukin-2/metabolism ; Male ; Treatment Outcome ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Heterologous prime-boost vaccination with MF59-adjuvanted H5 vaccines promotes antibody affinity maturation towards the hemagglutinin HA1 domain and broad H5N1 cross-clade neutralization.
Autorzy :
Khurana S; Division of Viral products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America.
Coyle EM; Division of Viral products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America.
Dimitrova M; Division of Viral products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America.
Castellino F; Novartis Vaccines and Diagnostics Srl, Sienna, Italy.
Nicholson K; Department of Infection, Inflammation, and Immunity, Maurice Shock Medical Sciences Building, University of Leicester, Leicester, United Kingdom.
Del Giudice G; Novartis Vaccines and Diagnostics Srl, Sienna, Italy.
Golding H; Division of Viral products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America.
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Źródło :
PloS one [PLoS One] 2014 Apr 22; Vol. 9 (4), pp. e95496. Date of Electronic Publication: 2014 Apr 22 (Print Publication: 2014).
Typ publikacji :
Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Immunization, Secondary*
Antibody Affinity/*immunology
Cross Reactions/*immunology
Hemagglutinins/*immunology
Influenza A Virus, H5N1 Subtype/*immunology
Influenza Vaccines/*immunology
Polysorbates/*administration & dosage
Squalene/*administration & dosage
Adjuvants, Immunologic/administration & dosage ; Antibodies, Viral/blood ; Cross-Priming/immunology ; Hemagglutinins/chemistry ; Humans ; Influenza, Human/immunology ; Influenza, Human/virology ; Neutralization Tests ; Protein Structure, Tertiary ; Vaccination ; Vaccines, Subunit/immunology
Czasopismo naukowe
Tytuł :
A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration.
Autorzy :
Della Cioppa G; Novartis Vaccines; Cambridge, MA USA.
Nicolay U; Novartis Vaccines; Cambridge, MA USA.
Lindert K; Novartis Vaccines; Cambridge, MA USA.
Leroux-Roels G; Centre for Vaccinology; CEVAC; Ghent University and University Hospital; Belgium.
Clement F; Centre for Vaccinology; CEVAC; Ghent University and University Hospital; Belgium.
Castellino F; Novartis Vaccines; Cambridge, MA USA.
Galli C; Novartis Vaccines; Cambridge, MA USA.
Groth N; Novartis Vaccines; Cambridge, MA USA.
Levin Y; NanoPass Technologies; Nes Ziona, Israel.
Del Giudice G; Novartis Vaccines; Cambridge, MA USA.
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Źródło :
Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2014; Vol. 10 (6), pp. 1701-10. Date of Electronic Publication: 2014 Apr 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dose-Response Relationship, Immunologic*
Adjuvants, Immunologic/*adverse effects
Influenza Vaccines/*adverse effects
Influenza Vaccines/*immunology
Influenza, Human/*prevention & control
Polysorbates/*adverse effects
Squalene/*adverse effects
Adjuvants, Immunologic/administration & dosage ; Aged ; Aged, 80 and over ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/pathology ; Female ; Humans ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza A Virus, H3N2 Subtype/immunology ; Influenza B virus/immunology ; Influenza Vaccines/administration & dosage ; Injections, Intradermal ; Injections, Intramuscular ; Male ; Polysorbates/administration & dosage ; Squalene/administration & dosage
Czasopismo naukowe
Tytuł :
Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses.
Autorzy :
Spensieri F; Research Center, Novartis Vaccines and Diagnostics, Srl, 53100 Siena, Italy.
Borgogni E
Zedda L
Bardelli M
Buricchi F
Volpini G
Fragapane E
Tavarini S
Finco O
Rappuoli R
Del Giudice G
Galli G
Castellino F
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Aug 27; Vol. 110 (35), pp. 14330-5. Date of Electronic Publication: 2013 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
Influenza Vaccines/*immunology
Influenza, Human/*immunology
Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Humans ; Influenza A virus/immunology ; Influenza Vaccines/administration & dosage ; Influenza, Human/blood ; Influenza, Human/prevention & control ; Interleukins ; Vaccination
Czasopismo naukowe
Tytuł :
Impact of preexisting memory to seasonal A/H1N1 influenza virus on the immune response following vaccination against avian A/H5N1 virus.
Autorzy :
Buricchi F; Research, Novartis Vaccines and Diagnostics, Siena, Italy.
Bardelli M
Malzone C
Capecchi B
Nicolay U
Fragapane E
Castellino F
Del Giudice G
Galli G
Finco O
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Źródło :
European journal of immunology [Eur J Immunol] 2013 Mar; Vol. 43 (3), pp. 641-8. Date of Electronic Publication: 2013 Jan 24.
Typ publikacji :
Journal Article
MeSH Terms :
Immunologic Memory*
Influenza A Virus, H1N1 Subtype/*immunology
Influenza A Virus, H5N1 Subtype/*immunology
Influenza Vaccines/*immunology
Influenza, Human/*immunology
Adult ; Animals ; Antibodies, Viral/immunology ; B-Lymphocytes/immunology ; Cross Reactions/immunology ; Humans ; Immunoglobulin G/immunology ; Influenza Vaccines/administration & dosage
Czasopismo naukowe
Tytuł :
Aflunov®: a vaccine tailored for pre-pandemic and pandemic approaches against influenza.
Autorzy :
Del Giudice G; Novartis Vaccines and Diagnostics, Siena, Italy. giuseppe. />Fragapane E
Della Cioppa G
Rappuoli R
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Źródło :
Expert opinion on biological therapy [Expert Opin Biol Ther] 2013 Jan; Vol. 13 (1), pp. 121-35. Date of Electronic Publication: 2012 Nov 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Influenza Vaccines/*therapeutic use
Influenza, Human/*prevention & control
Adult ; Aged ; Child ; Clinical Trials as Topic ; Feasibility Studies ; Humans ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/immunology ; Influenza, Human/immunology
Czasopismo naukowe
Tytuł :
One dose of an MF59-adjuvanted pandemic A/H1N1 vaccine recruits pre-existing immune memory and induces the rapid rise of neutralizing antibodies.
Autorzy :
Faenzi E; Research Development, Novartis Vaccines and Diagnostics srl, Siena, Italy.
Zedda L
Bardelli M
Spensieri F
Borgogni E
Volpini G
Buricchi F
Pasini FL
Capecchi PL
Montanaro F
Belli R
Lattanzi M
Piccirella S
Montomoli E
Ahmed SS
Rappuoli R
Del Giudice G
Finco O
Castellino F
Galli G
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Źródło :
Vaccine [Vaccine] 2012 Jun 08; Vol. 30 (27), pp. 4086-94. Date of Electronic Publication: 2012 Apr 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunologic Memory*
Adjuvants, Immunologic/*administration & dosage
Antibodies, Neutralizing/*blood
Antibodies, Viral/*blood
Influenza A Virus, H1N1 Subtype/*immunology
Influenza Vaccines/*immunology
Polysorbates/*administration & dosage
Squalene/*administration & dosage
Adolescent ; Adult ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; Cross Reactions ; Female ; Humans ; Influenza Vaccines/administration & dosage ; Male ; Middle Aged ; Vaccination/methods ; Young Adult
Czasopismo naukowe
Tytuł :
Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59 (®) adjuvant: results from a dose-finding clinical trial in older adults.
Autorzy :
Della Cioppa G; Novartis Vaccines and Diagnostics, Cambridge MA, USA. />Nicolay U
Lindert K
Leroux-Roels G
Clement F
Castellino F
Galli G
Groth N
Del Giudice G
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Źródło :
Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2012 Feb; Vol. 8 (2), pp. 216-27. Date of Electronic Publication: 2012 Feb 01.
Typ publikacji :
Clinical Trial; Journal Article; Randomized Controlled Trial
MeSH Terms :
Adjuvants, Immunologic*
Antibodies, Viral/*blood
Influenza Vaccines/*immunology
Influenza, Human/*immunology
Squalene/*immunology
Aged ; Antibodies, Viral/immunology ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology ; Female ; Humans ; Immunity, Cellular ; Influenza A Virus, H3N2 Subtype/immunology ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/adverse effects ; Influenza, Human/prevention & control ; Injections, Intramuscular ; Male ; Polysorbates/administration & dosage ; Squalene/administration & dosage ; Vaccination
Czasopismo naukowe
Tytuł :
New technologies for influenza vaccines.
Autorzy :
Dormitzer PR; Novartis Vaccines and Diagnostics, Cambridge, MA, USA. />Tsai TF
Del Giudice G
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Źródło :
Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2012 Jan; Vol. 8 (1), pp. 45-58. Date of Electronic Publication: 2012 Jan 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Design*
Biotechnology/*methods
Influenza Vaccines/*immunology
Influenza, Human/*prevention & control
Animals ; Cell Line ; Humans ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/genetics ; Influenza, Human/immunology ; Pandemics ; Vaccines, Attenuated/administration & dosage ; Vaccines, Attenuated/immunology ; Vaccines, Subunit/administration & dosage ; Vaccines, Subunit/immunology ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/immunology ; Virion/immunology
Czasopismo naukowe
Tytuł :
Hemagglutination inhibition antibody titers as a correlate of protection for inactivated influenza vaccines in children.
Autorzy :
Black S; Center for Global Health, University of Cincinnati Children's Hospital, Cincinnati, OH 45229, USA. />Nicolay U
Vesikari T
Knuf M
Del Giudice G
Della Cioppa G
Tsai T
Clemens R
Rappuoli R
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Źródło :
The Pediatric infectious disease journal [Pediatr Infect Dis J] 2011 Dec; Vol. 30 (12), pp. 1081-5.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Hemagglutination Inhibition Tests/*methods
Influenza A Virus, H1N1 Subtype/*immunology
Influenza A Virus, H3N2 Subtype/*immunology
Influenza Vaccines/*immunology
Influenza, Human/*prevention & control
Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Influenza Vaccines/administration & dosage ; Logistic Models ; Male
Czasopismo naukowe
Tytuł :
MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines.
Autorzy :
Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
Verma N
Yewdell JW
Hilbert AK
Castellino F
Lattanzi M
Del Giudice G
Rappuoli R
Golding H
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Źródło :
Science translational medicine [Sci Transl Med] 2011 Jun 01; Vol. 3 (85), pp. 85ra48.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
MeSH Terms :
Adjuvants, Immunologic/*therapeutic use
Influenza Vaccines/*immunology
Polysorbates/*therapeutic use
Squalene/*immunology
Squalene/*therapeutic use
Adolescent ; Adult ; Antibody Formation/immunology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza Vaccines/therapeutic use ; Male ; Middle Aged ; Pandemics/prevention & control ; Young Adult
Czasopismo naukowe

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