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Wyszukujesz frazę ""Delattre, O."" wg kryterium: Autor


Tytuł :
Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis.
Autorzy :
El-Naggar AM; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.; Department of Pathology, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt.
Somasekharan SP; Vancouver Prostate Centre, Vancouver, BC, Canada.
Wang Y; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Cheng H; Vancouver Prostate Centre, Vancouver, BC, Canada.
Negri GL; Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Pan M; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Wang XQ; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Delaidelli A; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Rafn B; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Cran J; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Zhang F; Vancouver Prostate Centre, Vancouver, BC, Canada.
Zhang H; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Colborne S; Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Gleave M; Vancouver Prostate Centre, Vancouver, BC, Canada.
Mandinova A; Brigham and Women's Hospital, Harvard University, Boston, MA, USA.
Kedersha N; Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Hughes CS; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Surdez D; Centre de recherche de l'Institut Curie, Paris, France.
Delattre O; Centre de recherche de l'Institut Curie, Paris, France.
Wang Y; Vancouver Prostate Centre, Vancouver, BC, Canada.
Huntsman DG; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Morin GB; Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Sorensen PH; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
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Źródło :
EMBO reports [EMBO Rep] 2019 Dec 05; Vol. 20 (12), pp. e48375. Date of Electronic Publication: 2019 Oct 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Wiley Blackwell Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep. Subsets: MEDLINE
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Benzamides/*therapeutic use
Bone Neoplasms/*drug therapy
Histone Deacetylase Inhibitors/*therapeutic use
Pyridines/*therapeutic use
Sarcoma, Ewing/*drug therapy
Transcription Factors/*metabolism
Acetylation ; Animals ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cells, Cultured ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mice ; NF-E2-Related Factor 2/metabolism ; Neoplasm Metastasis ; Oxidative Stress ; Sarcoma, Ewing/metabolism ; Sarcoma, Ewing/pathology
Czasopismo naukowe
Tytuł :
Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response.
Autorzy :
Pishas KI; Cancer Therapeutics Laboratory, Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia.; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Drenberg CD; Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio.; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
Taslim C; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Theisen ER; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Johnson KM; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Saund RS; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Pop IL; Huntsman Cancer Institute, School of Medicine, University of Utah, Salt Lake City, Utah.
Crompton BD; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.
Lawlor ER; Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan.; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
Tirode F; Univ Lyon, Universite Claude Bernard Lyon, Centre Leon Berard, Cancer Research Center of Lyon, Lyon, France.
Mora J; Department of Pediatric Hemato-Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.
Delattre O; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.
Beckerle MC; Huntsman Cancer Institute, School of Medicine, University of Utah, Salt Lake City, Utah.
Callen DF; Cancer Therapeutics Laboratory, Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Sharma S; TGen Clinical Sciences, Applied Cancer Research and Drug Discovery, Phoenix, Arizona.
Lessnick SL; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio. .; Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Ohio State University, Columbus, Ohio.
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2018 Sep; Vol. 17 (9), pp. 1902-1916. Date of Electronic Publication: 2018 Jul 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol. Cancer Ther. Subsets: MEDLINE
MeSH Terms :
Bone Neoplasms/*drug therapy
Endoplasmic Reticulum Stress/*drug effects
Enzyme Inhibitors/*pharmacology
Histone Demethylases/*antagonists & inhibitors
Sarcoma, Ewing/*drug therapy
Adolescent ; Apoptosis/drug effects ; Apoptosis/genetics ; Bone Neoplasms/enzymology ; Bone Neoplasms/genetics ; Cell Line, Tumor ; Child ; Endoplasmic Reticulum Stress/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Humans ; RNA Interference ; Sarcoma, Ewing/enzymology ; Sarcoma, Ewing/genetics ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Small Molecule Libraries/pharmacology
Czasopismo naukowe
Tytuł :
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility.
Autorzy :
Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU, 80337, Munich, Germany.; German Consortium for Cancer Research (DKTK), 69120, Heidelberg, Germany.; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Surdez D; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, 75005, Paris, France.; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France.
Reynaud S; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France.; Unité de Génétique Somatique, Institut Curie, Centre Hospitalier, 75005, Paris, France.
Mirabeau O; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, 75005, Paris, France.; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France.
Karlins E; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, 21701, USA.
Rubio RA; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU, 80337, Munich, Germany.
Zaidi S; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, 75005, Paris, France.; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France.
Grossetete-Lalami S; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, 75005, Paris, France.; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France.
Ballet S; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France.; Unité de Génétique Somatique, Institut Curie, Centre Hospitalier, 75005, Paris, France.
Lapouble E; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France.; Unité de Génétique Somatique, Institut Curie, Centre Hospitalier, 75005, Paris, France.
Laurence V; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France.
Michon J; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France.
Pierron G; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France.; Unité de Génétique Somatique, Institut Curie, Centre Hospitalier, 75005, Paris, France.
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090, Vienna, Austria.
Gaspar N; Department of Oncology for Child and Adolescent, Institut Gustave Roussy, 94800, Villejuif, France.
Kontny U; Division of Pediatric Hematology Oncology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, 52062, Aachen, Germany.
González-Neira A; Human Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, 28029, Madrid, Spain.
Picci P; Laboratorio di Oncologia Sperimentale, Istituto Ortopedico Rizzoli di Bologna, 40136, Bologna, Italy.
Alonso J; Unidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, 28220, Majadahonda, Spain.
Patino-Garcia A; Laboratory of Pediatrics, University of Navarra, University Clinic of Navarra, IdiSNA, 31008, Pamplona, Spain.
Corradini N; Institute for Paediatric Haematology and Oncology, Leon Bérard Cancer Centre, University of Lyon, 69008, Lyon, France.
Bérard PM; Institute for Paediatric Haematology and Oncology, Leon Bérard Cancer Centre, University of Lyon, 69008, Lyon, France.
Freedman ND; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Rothman N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Dagnall CL; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, 21701, USA.
Burdett L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, 21701, USA.
Jones K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, 21701, USA.
Manning M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, 21701, USA.
Wyatt K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, 21701, USA.
Zhou W; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, 21701, USA.
Yeager M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, 21701, USA.
Cox DG; Centre Léon Bérard, INSERM U1052, 69008, Lyon, France.
Hoover RN; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Khan J; Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA.
Armstrong GT; Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Leisenring WM; Cancer Prevention and Clinical Statistics Programs, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Bhatia S; Institute for Cancer Outcomes and Survivorship, University of Alabama, Birmingham, AL, 35294, USA.
Robison LL; Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Kulozik AE; University Children's Hospital of Heidelberg, 69120, Heidelberg, Germany.
Kriebel J; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.
Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, 80333, Munich, Germany.
Metzler M; University Children's Hospital of Erlangen, 91054, Erlangen, Germany.
Hartmann W; Gerhard-Domagk Institute of Pathology, University Hospital of Münster, 48149, Münster, Germany.
Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, 80539, Germany.
Kirchner T; German Consortium for Cancer Research (DKTK), 69120, Heidelberg, Germany.; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Institute of Pathology, Faculty of Medicine, LMU, 80337, Munich, Germany.
Dirksen U; University Children's Hospital of Essen, 45147, Essen, Germany.
Morton LM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Mirabello L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Tucker MA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Tirode F; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, 75005, Paris, France.; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France.
Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA. .
Delattre O; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, 75005, Paris, France. olivier.delattre@curie.fr.; SIREDO Oncology Centre, Institut Curie, 75005, Paris, France. olivier.delattre@curie.fr.
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Źródło :
Nature communications [Nat Commun] 2018 Aug 09; Vol. 9 (1), pp. 3184. Date of Electronic Publication: 2018 Aug 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info :
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
MeSH Terms :
Gene Expression Profiling*
Genetic Predisposition to Disease*
Genome-Wide Association Study*
Sarcoma, Ewing/*genetics
Alleles ; Cell Cycle Proteins/genetics ; Cell Proliferation/genetics ; DNA-Binding Proteins/genetics ; European Continental Ancestry Group ; Gene Expression Regulation, Neoplastic ; Genotype ; Homeodomain Proteins/genetics ; Humans ; Oncogene Proteins, Fusion/genetics ; Polymorphism, Single Nucleotide ; Proto-Oncogene Protein c-fli-1/genetics ; Quality Control ; Quantitative Trait Loci ; RNA-Binding Protein EWS/genetics ; Risk ; Sarcoma, Ewing/ethnology ; Transcription Factors/genetics ; Zebrafish Proteins
Czasopismo naukowe
Tytuł :
Ewing sarcoma.
Autorzy :
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; German Cancer Consortium, partner site Munich, Munich, Germany. .; German Cancer Research Center, Heidelberg, Germany. .
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; German Cancer Consortium, partner site Munich, Munich, Germany. .; German Cancer Research Center, Heidelberg, Germany. .
Surdez D; INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Tomazou EM; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
de Álava E; Institute of Biomedicine of Seville, Virgen del Rocío University Hospital/CSIC/University of Seville/CIBERONC, Seville, Spain.
Kovar H; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University Vienna, Vienna, Austria.
Sorensen PH; British Columbia Cancer Research Centre and University of British Columbia, Vancouver, Canada.
Delattre O; INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Dirksen U; German Cancer Research Center, Heidelberg, Germany.; Cooperative Ewing Sarcoma Study group, Essen University Hospital, Essen, Germany.; German Cancer Consortium, partner site Essen, Essen, Germany.
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Źródło :
Nature reviews. Disease primers [Nat Rev Dis Primers] 2018 Jul 05; Vol. 4 (1), pp. 5. Date of Electronic Publication: 2018 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101672103 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-676X (Electronic) Linking ISSN: 2056676X NLM ISO Abbreviation: Nat Rev Dis Primers Subsets: MEDLINE
MeSH Terms :
Sarcoma, Ewing/*diagnosis
12E7 Antigen/analysis ; 12E7 Antigen/blood ; Humans ; Neoplasm Metastasis/physiopathology ; Proto-Oncogene Protein c-fli-1/analysis ; Proto-Oncogene Protein c-fli-1/blood ; Quality of Life/psychology ; RNA-Binding Protein EWS/analysis ; RNA-Binding Protein EWS/blood ; Radiography/methods ; Risk Factors ; Sarcoma, Ewing/blood ; Sarcoma, Ewing/physiopathology
Czasopismo naukowe
Tytuł :
Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells.
Autorzy :
Franzetti GA; Institut Curie, PSL Research University, Paris cedex 05, France.; INSERM U830, Genetic and Biology of Pediatric Tumors group, Institut Curie Research Center, Paris, France.
Laud-Duval K; Institut Curie, PSL Research University, Paris cedex 05, France.; INSERM U830, Genetic and Biology of Pediatric Tumors group, Institut Curie Research Center, Paris, France.
van der Ent W; Institut Curie, PSL Research University, Paris cedex 05, France.; INSERM U830, Genetic and Biology of Pediatric Tumors group, Institut Curie Research Center, Paris, France.; Institute of Biology, Leiden University, Leiden, The Netherlands.
Brisac A; Institut Curie, PSL Research University, Paris cedex 05, France.; INSERM U830, Genetic and Biology of Pediatric Tumors group, Institut Curie Research Center, Paris, France.
Irondelle M; Institut Curie, PSL Research University, Paris cedex 05, France.; UMR144, Membrane and Cytoskeleton Dynamics group, Institut Curie Research Center, Paris, France.; UMR144, Cell and Tissue Imaging Facility (PICT IBiSA), Institut Curie Research Center, Paris, France.
Aubert S; Department of Pathology, University Hospital, Lille, France.
Dirksen U; Department of Pediatric Hematology and Oncology, University Hospital Muenster, Albert-Schweitzer Campus 1, A1 and Westfalian Wilhelms University, Muenster, Germany.
Bouvier C; Department of Pathology, La Timone University Hospital, Marseille, France.
de Pinieux G; Department of Pathology, University Hospital of Tours and University François Rabelais, Chambray-lès-Tours, France.
Snaar-Jagalska E; Institute of Biology, Leiden University, Leiden, The Netherlands.
Chavrier P; Institut Curie, PSL Research University, Paris cedex 05, France.; UMR144, Membrane and Cytoskeleton Dynamics group, Institut Curie Research Center, Paris, France.
Delattre O; Institut Curie, PSL Research University, Paris cedex 05, France.; INSERM U830, Genetic and Biology of Pediatric Tumors group, Institut Curie Research Center, Paris, France.
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Źródło :
Oncogene [Oncogene] 2017 Jun 22; Vol. 36 (25), pp. 3505-3514. Date of Electronic Publication: 2017 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
MeSH Terms :
Cell Movement*
Cell Proliferation*
Gene Expression Regulation, Neoplastic*
Calmodulin-Binding Proteins/*biosynthesis
Oncogene Proteins, Fusion/*biosynthesis
Proto-Oncogene Protein c-fli-1/*biosynthesis
RNA-Binding Proteins/*biosynthesis
Sarcoma, Ewing/*metabolism
Animals ; Calmodulin-Binding Proteins/genetics ; Cell Line, Tumor ; Mice ; Mice, SCID ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Oncogene Proteins, Fusion/genetics ; Proto-Oncogene Protein c-fli-1/genetics ; RNA-Binding Protein EWS ; RNA-Binding Proteins/genetics ; Sarcoma, Ewing/genetics ; Sarcoma, Ewing/pathology ; Zebrafish
Czasopismo naukowe
Tytuł :
Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model.
Autorzy :
Minas TZ; Department of Oncology, Georgetown University Medical Center, Washington, DC, United States of America.
Surdez D; Genetics and Biology of Cancers Unit, Institut Curie Research Center, PSL Research University, Île-de-France, Paris, France.; INSERM U830, Institut Curie Research Center, Île-de-France, Paris, France.
Javaheri T; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Tanaka M; Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Howarth M; Division of Hematology and Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States of America.
Kang HJ; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, United States of America.
Han J; Department of Oncology, Georgetown University Medical Center, Washington, DC, United States of America.
Han ZY; Genetics and Biology of Cancers Unit, Institut Curie Research Center, PSL Research University, Île-de-France, Paris, France.; INSERM U830, Institut Curie Research Center, Île-de-France, Paris, France.
Sax B; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Kream BE; Department of Medicine, and Genetics and Genome Sciences, University of Connecticut Health Science Center, Farmington, CT, United States of America.
Hong SH; Department of Oncology, Georgetown University Medical Center, Washington, DC, United States of America.
Çelik H; Department of Oncology, Georgetown University Medical Center, Washington, DC, United States of America.
Tirode F; Genetics and Biology of Cancers Unit, Institut Curie Research Center, PSL Research University, Île-de-France, Paris, France.; INSERM U830, Institut Curie Research Center, Île-de-France, Paris, France.
Tuckermann J; Institute of Comparative Molecular Endocrinology (CME), University of Ulm, Ulm, Germany.
Toretsky JA; Department of Oncology, Georgetown University Medical Center, Washington, DC, United States of America.
Kenner L; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.; Department of Pathology of Laboratory Animals (UPLA), University of Veterinary Medicine, Vienna, Austria.
Kovar H; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.; Children´s Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Lee S; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, United States of America.
Sweet-Cordero EA; Division of Hematology and Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States of America.
Nakamura T; Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Moriggl R; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.
Delattre O; Genetics and Biology of Cancers Unit, Institut Curie Research Center, PSL Research University, Île-de-France, Paris, France.; INSERM U830, Institut Curie Research Center, Île-de-France, Paris, France.; Unité de génétique somatique, Institut Curie, Île-de-France, Paris, France.
Üren A; Department of Oncology, Georgetown University Medical Center, Washington, DC, United States of America.
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Źródło :
Oncotarget [Oncotarget] 2017 May 23; Vol. 8 (21), pp. 34141-34163.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: Print Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: MEDLINE
MeSH Terms :
Disease Models, Animal*
Promoter Regions, Genetic*
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*pathology
Adenoviridae/genetics ; Animals ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Gene Knock-In Techniques ; Humans ; Mice ; Mice, Transgenic ; Neoplasm Transplantation ; Sarcoma, Ewing/genetics
Czasopismo naukowe
Tytuł :
DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.
Autorzy :
Sheffield NC; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Pierron G; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.
Klughammer J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Datlinger P; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schönegger A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schuster M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Hadler J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Surdez D; Institut Curie, PSL Research University, INSERM, U830, Paris, France.
Guillemot D; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.
Lapouble E; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.
Freneaux P; Institut Curie, PSL Research University, Service de Pathologie, Pole de Medecine Diagnostique et Theranostique, Paris, France.
Champigneulle J; Service d'Anatomie et de Cytologie Pathologiques, Hopitaux de Brabois, Hopital d'Adultes, Nancy, France.
Bouvier R; Centre de Pathologie du Pôle Est, Hopitaux de Lyon, Lyon, France.
Walder D; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Ambros IM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Hutter C; St. Anna Children's Hospital, St. Anna Kinderspital, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Sorz E; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Amaral AT; Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital/CSIC/University of Sevilla, Seville, Spain.
de Álava E; Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital/CSIC/University of Sevilla, Seville, Spain.
Schallmoser K; Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.; Department of Blood Group Serology and Transfusion Medicine, Paracelsus Medical University, Salzburg, Austria.
Strunk D; Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.; Institute for Experimental and Clinical Cell Therapy, Paracelsus Medical University, Salzburg, Austria.
Rinner B; Division of Biomedical Research, Medical University of Graz, Graz, Austria.
Liegl-Atzwanger B; Institute of Pathology, Medical University of Graz, Graz, Austria.
Huppertz B; Organizational Unit of Research Infrastructure, Biobank Graz, Medical University of Graz, Graz, Austria.
Leithner A; Department of Orthopedic Surgery, Medical University of Graz, Graz, Austria.
de Pinieux G; Service d'Anatomie et de Cytologie Pathologiques, Hôpital Universitaire Trousseau, Tours, France.
Terrier P; Gustave Roussy, Département de Pathologie, Villejuif, France.
Laurence V; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.; Institut Curie, PSL Research University, Departement d'Oncologie Pédiatrique Adolescent Jeunes Adultes, Paris, France.
Michon J; Institut Curie, PSL Research University, Departement d'Oncologie Pédiatrique Adolescent Jeunes Adultes, Paris, France.
Ladenstein R; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; St. Anna Children's Hospital, St. Anna Kinderspital, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Holter W; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; St. Anna Children's Hospital, St. Anna Kinderspital, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Windhager R; Department of Orthopedics, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
Dirksen U; University Hospital Münster, Department of Pediatrics and Pediatric Hematology and Oncology, Münster, Germany.
Ambros PF; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Delattre O; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.; Institut Curie, PSL Research University, INSERM, U830, Paris, France.
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.; Max Planck Institute for Informatics, Saarland Informatics Campus, Saarbrücken, Germany.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Tomazou EM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
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Źródło :
Nature medicine [Nat Med] 2017 Mar; Vol. 23 (3), pp. 386-395. Date of Electronic Publication: 2017 Jan 30.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat. Med. Subsets: MEDLINE
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Bone Neoplasms/*genetics
DNA Methylation/*genetics
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
Adolescent ; Adult ; Cell Line, Tumor ; Child ; Child, Preschool ; Epigenesis, Genetic ; Female ; Genetic Heterogeneity ; Humans ; Male ; Middle Aged ; Promoter Regions, Genetic/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma.
Autorzy :
Cidre-Aranaz F; Unidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Majadahonda, Spain.
Grünewald TG; INSERM U830 'Genetics and Biology of Cancers' Institut Curie Research Center, Paris, France.; Laboratory for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Surdez D; INSERM U830 'Genetics and Biology of Cancers' Institut Curie Research Center, Paris, France.
García-García L; Unidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Majadahonda, Spain.
Carlos Lázaro J; Unidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Majadahonda, Spain.
Kirchner T; Laboratory for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
González-González L; Unidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Majadahonda, Spain.
Sastre A; Unidad hemato-oncología pediátrica, Hospital Infantil Universitario La Paz, Madrid, Spain.
García-Miguel P; Unidad hemato-oncología pediátrica, Hospital Infantil Universitario La Paz, Madrid, Spain.
López-Pérez SE; Unidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Majadahonda, Spain.
Monzón S; Unidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Majadahonda, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER U758), Instituto de Salud Carlos III, Madrid, Spain.
Delattre O; INSERM U830 'Genetics and Biology of Cancers' Institut Curie Research Center, Paris, France.
Alonso J; Unidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Majadahonda, Spain.
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Źródło :
Oncogene [Oncogene] 2017 Feb 09; Vol. 36 (6), pp. 766-776. Date of Electronic Publication: 2016 Jul 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
MeSH Terms :
Membrane Proteins/*metabolism
Oncogene Proteins, Fusion/*metabolism
Phosphoproteins/*metabolism
Proto-Oncogene Protein c-fli-1/*metabolism
RNA-Binding Protein EWS/*metabolism
Sarcoma, Ewing/*metabolism
Sarcoma, Ewing/*pathology
ras Proteins/*antagonists & inhibitors
Animals ; Cell Line, Tumor ; Female ; Heterografts ; Humans ; MAP Kinase Signaling System ; Male ; Mice ; Mice, SCID ; Signal Transduction ; ras Proteins/metabolism
Czasopismo naukowe
Tytuł :
High-throughput RNAi screen in Ewing sarcoma cells identifies leucine rich repeats and WD repeat domain containing 1 (LRWD1) as a regulator of EWS-FLI1 driven cell viability.
Autorzy :
He T; VTT Technical Research Centre of Finland, Turku, Finland.
Surdez D; Institut Curie, Unité de génétique somatique, Paris, France; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France; INSERM U830, Institut Curie Research Center, Paris, France.
Rantala JK; Misvik Biology, Turku, Finland.
Haapa-Paananen S; VTT Technical Research Centre of Finland, Turku, Finland.
Ban J; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Kauer M; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Tomazou E; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Fey V; VTT Technical Research Centre of Finland, Turku, Finland.
Alonso J; Unidad de Tumores Sólidos Infantiles, Área de Genética Humana, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain.
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria; Department of Pediatrics, Medical University, Vienna, Austria.
Delattre O; Institut Curie, Unité de génétique somatique, Paris, France; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France; INSERM U830, Institut Curie Research Center, Paris, France; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.
Iljin K; VTT Technical Research Centre of Finland, Turku, Finland. Electronic address: .
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Źródło :
Gene [Gene] 2017 Jan 05; Vol. 596, pp. 137-146. Date of Electronic Publication: 2016 Oct 17.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE
MeSH Terms :
Bone Neoplasms/*genetics
Microtubule Proteins/*genetics
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
Bone Neoplasms/mortality ; Bone Neoplasms/pathology ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Survival/genetics ; Doxycycline/pharmacology ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; High-Throughput Nucleotide Sequencing ; Humans ; Kaplan-Meier Estimate ; Male ; Microtubule Proteins/metabolism ; Oncogene Proteins, Fusion/metabolism ; Proto-Oncogene Protein c-fli-1/metabolism ; RNA Interference ; RNA-Binding Protein EWS/metabolism ; Sarcoma, Ewing/mortality ; Sarcoma, Ewing/pathology ; WD40 Repeats
Czasopismo naukowe
Tytuł :
Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome.
Autorzy :
Ruiz-Pinto S; Human Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Pita G; Human Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Patiño-García A; Clinical Genetics Unit, University Clinic of Navarra (CUN), Pamplona, Spain.
García-Miguel P; Department of Pediatric Hemato-Oncology, Hospital Universitario La Paz, Madrid, Spain.
Alonso J; Pediatric Solid Tumor Laboratory, Human Genetic Department, Research Institute of Rare Diseases, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
Pérez-Martínez A; Department of Pediatric Hemato-Oncology, Hospital Universitario La Paz, Madrid, Spain.
Sastre A; Department of Pediatric Hemato-Oncology, Hospital Universitario La Paz, Madrid, Spain.
Gómez-Mariano G; Pediatric Solid Tumor Laboratory, Human Genetic Department, Research Institute of Rare Diseases, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
Lissat A; Department of Pediatrics, Division of Oncology and Hematology, Charité Universitaetsmedizin, Berlin, Germany.
Scotlandi K; Experimental Oncology Laboratory, Istituto Ortopedico Rizzoli, Bologna, Italy.
Serra M; Experimental Oncology Laboratory, Istituto Ortopedico Rizzoli, Bologna, Italy.
Ladenstein R; Department of Pediatrics, Children's Cancer Research Institute, St Anna Kinderkrebsforschung e.V., Medical University, Vienna, Austria.
Lapouble E; Somatic Genetics Unit, Institut Curie, Paris, France.
Pierron G; Somatic Genetics Unit, Institut Curie, Paris, France.
Kontny U; Division of Paediatric Haematology, Oncology and Stem Cell Transplantation, Department of Paediatrics and Adolescent Medicine, University Medical Centre, Aachen, Germany.
Picci P; Experimental Oncology Laboratory, Istituto Ortopedico Rizzoli, Bologna, Italy.
Kovar H; Department of Pediatrics, Children's Cancer Research Institute, St Anna Kinderkrebsforschung e.V., Medical University, Vienna, Austria.
Delattre O; Inserm U830, Centre de Recherche, Institut Curie, Paris, France.
González-Neira A; Human Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain .
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Źródło :
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2016 Sep; Vol. 27 (9), pp. 1788-93. Date of Electronic Publication: 2016 Jun 10.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann. Oncol. Subsets: MEDLINE
MeSH Terms :
Cytochrome P-450 CYP2C8/*genetics
Multidrug Resistance-Associated Proteins/*genetics
Sarcoma, Ewing/*genetics
ATP Binding Cassette Transporter, Subfamily B/genetics ; Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Genetic Association Studies ; Genotype ; Humans ; Infant ; Male ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Polymorphism, Single Nucleotide ; Sarcoma, Ewing/drug therapy ; Sarcoma, Ewing/pathology ; Survival Analysis ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
[Cooperation between a somatic mutation and a genetic susceptibility variant in Ewing sarcoma].
Transliterated Title :
Coopération entre mutation somatique et variant génétique de susceptibilité dans le sarcome d'Ewing.
Autorzy :
Grünewald TG; Laboratory for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Thalkirchnerstrasse 36, 80337 Munich, Allemagne - Institut Curie, PSL Research University, unité de Génétique et Biologie des Cancers, 26, rue d'Ulm, 75248 Cedex 05 Paris, France - Inserm U830, Institut Curie, Centre de recherches, 26, rue d'Ulm, 75248 Paris, France.
Gilardi-Hebenstreit P; École normale supérieure, PSL Research University, Inserm U1024, CNRS UMR8197, Institut de biologie de l'ENS (IBENS), 46, rue d'Ulm, 75005 Paris, France.
Charnay P; École normale supérieure, PSL Research University, Inserm U1024, CNRS UMR8197, Institut de biologie de l'ENS (IBENS), 46, rue d'Ulm, 75005 Paris, France.
Delattre O; Institut Curie, PSL Research University, unité de Génétique et Biologie des Cancers, 26, rue d'Ulm, 75248 Cedex 05 Paris, France - Inserm U830, Institut Curie, Centre de recherches, 26, rue d'Ulm, 75248 Paris, France - Unité Génétique Somatique (UGS), Institut Curie, Centre hospitalier, 26, rue d'Ulm, 75248 Paris, France.
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Źródło :
Medecine sciences : M/S [Med Sci (Paris)] 2016 Apr; Vol. 32 (4), pp. 323-6. Date of Electronic Publication: 2016 May 02.
Typ publikacji :
Wiadomości
Journal Info :
Publisher: EDK Country of Publication: France NLM ID: 8710980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1958-5381 (Electronic) Linking ISSN: 07670974 NLM ISO Abbreviation: Med Sci (Paris) Subsets: MEDLINE
MeSH Terms :
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Bone Neoplasms/*genetics
Mutation/*physiology
Sarcoma, Ewing/*genetics
Bone Neoplasms/pathology ; Early Growth Response Protein 2/genetics ; Epistasis, Genetic ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Oncogene Proteins, Fusion/physiology ; Sarcoma, Ewing/pathology
Periodyk
Tytuł :
The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease.
Autorzy :
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University Vienna, Vienna, Austria.
Amatruda J; Departments of Pediatrics, Molecular Biology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Brunet E; Museum National d'Histoire Naturelle, INSERM U1154, CNRS 7196, Paris, France.
Burdach S; Children's Cancer Research Center and Department of Pediatrics, Klinikum rechts der Isar, Technical University and Comprehensive Cancer Center Munich (CCCM), Munich, Germany.
Cidre-Aranaz F; Unidad de Tumores Sólidos Infantiles, Área de Genética Humana, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain.
de Alava E; Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital /CSIC/University de Sevilla, Department of Pathology, Seville, Spain.
Dirksen U; University Children´s Hospital Muenster, Pediatric Hematology and Oncology, Muenster, Germany.
van der Ent W; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; Institute of Biology, Leiden University, Leiden, The Netherlands.
Grohar P; Van Andel Institute, Center for Cancer and Cell Biology and Helen DeVos Children's Hospital, Grand Rapids, MI, USA.
Grünewald TG; Laboratory for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Helman L; Center for Cancer Rearch, NCI, NIH, Bethesda, MA, USA.
Houghton P; Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX, USA.
Iljin K; VTT Technical Research Centre of Finland Ltd, Espoo, Finland.
Korsching E; Institute of Bioinformatics, Faculty of Medicine, University of Muenster, Muenster, Germany.
Ladanyi M; Department of Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Lawlor E; Department of Pediatrics and Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Lessnick S; Center for Childhood Cancer and Blood Disorders, Nationwide Children's Hospital, and the Division of Pediatric Hematology/Oncology/BMT, The Ohio State University, Columbus, OH, USA.
Ludwig J; Department of Sarcoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Meltzer P; Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Metzler M; Pediatric Oncology and Hematology, University Hospital Erlangen, Erlangen, Germany.
Mora J; Department of Pediatric Oncology, Sant Joan de Déu Hospital, Barcelona, Spain.
Moriggl R; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine and Medical University, Vienna, Austria.
Nakamura T; Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Papamarkou T; University of Glasgow, School of Mathematics and Statistics, Glasgow, UK.
Radic Sarikas B; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Rédini F; INSERM UMR957, Université de Nantes, Nantes, France.
Richter GH; Children's Cancer Research Center and Department of Pediatrics, Klinikum rechts der Isar, Technical University and Comprehensive Cancer Center Munich (CCCM), Munich, Germany.
Rossig C; University Children´s Hospital Muenster, Pediatric Hematology and Oncology, Muenster, Germany.
Schadler K; Department of Pediatrics Research, MD Anderson Cancer Center, Houston, TX, USA.
Schäfer BW; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.
Scotlandi K; CRS Development of Biomolecular Therapies, Experimental Oncology Lab, Rizzoli Institute, Bologna, Italy.
Sheffield NC; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Shelat A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis,TN, USA.
Snaar-Jagalska E; Institute of Biology, Leiden University, Leiden, The Netherlands.
Sorensen P; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.
Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA.
Stewart E; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Sweet-Cordero A; Division of Hematology and Oncology, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Szuhai K; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.
Tirado OM; Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Tirode F; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.
Toretsky J; Department of Oncology, Georgetown University School of Medicine, Washington, DC, USA.
Tsafou K; Department of Oncology, Georgetown University School of Medicine, Washington, DC, USA.
Üren A; Department of Oncology, Georgetown University School of Medicine, Washington, DC, USA.
Zinovyev A; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; INSERM, U900, Paris, France.; Ecole des Mines ParisTech, Fontainbleau, France.
Delattre O; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.
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Źródło :
Oncotarget [Oncotarget] 2016 Feb 23; Vol. 7 (8), pp. 8613-24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
Journal Info :
Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: Print Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: MEDLINE
MeSH Terms :
Bone Neoplasms/*pathology
Oncogene Proteins, Fusion/*metabolism
Proto-Oncogene Protein c-fli-1/*metabolism
RNA-Binding Protein EWS/*metabolism
Sarcoma, Ewing/*pathology
Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Sarcoma, Ewing/genetics ; Sarcoma, Ewing/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Ewing Sarcoma: Current Management and Future Approaches Through Collaboration.
Autorzy :
Gaspar N; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Hawkins DS; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Dirksen U; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Lewis IJ; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Ferrari S; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Le Deley MC; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Kovar H; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Grimer R; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Whelan J; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Claude L; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Delattre O; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Paulussen M; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Picci P; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Sundby Hall K; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
van den Berg H; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Ladenstein R; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Michon J; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Hjorth L; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Judson I; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Luksch R; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Bernstein ML; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Marec-Bérard P; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Brennan B; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Craft AW; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Womer RB; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Juergens H; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Oberlin O; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
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Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2015 Sep 20; Vol. 33 (27), pp. 3036-46. Date of Electronic Publication: 2015 Aug 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
Journal Info :
Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J. Clin. Oncol. Subsets: MEDLINE
MeSH Terms :
Interdisciplinary Communication*
International Cooperation*
Bone Neoplasms/*therapy
Medical Oncology/*trends
Pediatrics/*trends
Sarcoma, Ewing/*therapy
Adolescent ; Age of Onset ; Bone Neoplasms/diagnosis ; Bone Neoplasms/mortality ; Child ; Cooperative Behavior ; Diffusion of Innovation ; Forecasting ; Humans ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/mortality ; Survivors ; Time Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.
Autorzy :
Grünewald TG; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Bernard V; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.
Gilardi-Hebenstreit P; École Normale Supérieure (ENS), Institut de Biologie de l'ENS (IBENS), INSERM U1024, CNRS UMR8197, Paris, France.
Raynal V; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.
Surdez D; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Aynaud MM; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Mirabeau O; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Cidre-Aranaz F; Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain.
Tirode F; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Zaidi S; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Perot G; INSERM U916 Biology of Sarcomas, Institut Bergonié, Bordeaux, France.
Jonker AH; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Lucchesi C; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Le Deley MC; Département d'Epidémiologie et de Biostatistiques, Institut Gustave Roussy, Villejuif, France.
Oberlin O; Département de Pédiatrie, Institut Gustave Roussy, Villejuif, France.
Marec-Bérard P; Institute for Pediatric Hematology and Oncology, Leon-Bérard Cancer Center, University of Lyon, Lyon, France.
Véron AS; INSERM U1052, Léon-Bérard Cancer Centre, Cancer Research Center of Lyon, Lyon, France.
Reynaud S; Unité Génétique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
Lapouble E; Unité Génétique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
Boeva V; INSERM U900, Bioinformatics, Biostatistics, Epidemiology and Computational Systems Biology of Cancer, Institut Curie Research Center, Paris, France.; Mines ParisTech, Fontainebleau, France.
Rio Frio T; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.
Alonso J; Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain.
Bhatia S; Institute for Cancer Outcomes and Survivorship, School of Medicine, University of Alabama, Birmingham, Alabama, USA.
Pierron G; Unité Génétique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
Cancel-Tassin G; Centre de Recherche sur les Pathologies Prostatiques (CeRePP)-Laboratory for Urology, Research Team 2, UPMC, Hôpital Tenon, Paris, France.
Cussenot O; Centre de Recherche sur les Pathologies Prostatiques (CeRePP)-Laboratory for Urology, Research Team 2, UPMC, Hôpital Tenon, Paris, France.
Cox DG; INSERM U1052, Léon-Bérard Cancer Centre, Cancer Research Center of Lyon, Lyon, France.
Morton LM; Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Bethesda, Maryland, USA.
Machiela MJ; Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Bethesda, Maryland, USA.
Chanock SJ; Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Bethesda, Maryland, USA.
Charnay P; École Normale Supérieure (ENS), Institut de Biologie de l'ENS (IBENS), INSERM U1024, CNRS UMR8197, Paris, France.
Delattre O; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.; Unité Génétique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
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Źródło :
Nature genetics [Nat Genet] 2015 Sep; Vol. 47 (9), pp. 1073-8. Date of Electronic Publication: 2015 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat. Genet. Subsets: MEDLINE
MeSH Terms :
Bone Neoplasms/*genetics
Early Growth Response Protein 2/*genetics
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
Animals ; Base Sequence ; Bone Neoplasms/pathology ; Carotenoids/genetics ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression ; Gene Expression Regulation, Neoplastic ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Mice, SCID ; Microsatellite Repeats ; Molecular Sequence Data ; Neoplasm Transplantation ; Oxygenases/genetics ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Sarcoma, Ewing/pathology ; Tumor Burden
Czasopismo naukowe
Tytuł :
Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe.
Autorzy :
Bölling T; Department Osnabrueck, Center for Radiotherapy Rheine-Osnabrueck, Osnabrueck, Germany.
Braun-Munzinger G; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Burdach S; Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Calaminus G; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Craft A; Royal Victoria Infirmary, Newcastle, United Kingdom.
Delattre O; Inserm U830, Laboratory of Genetics and Biology of Cancers, Institut Curie, Paris, France.
Deley MC; Université Paris-Sud, Le Kremlin-Bicêtre, and Gustave Roussy Institute, Villejuif, France.
Dirksen U; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Dockhorn-Dworniczak B; Zentrum für Pathologie Kempten-Allgäu, Kempten, Germany.
Dunst J; Department of Radiation Oncology, University of Luebeck and University Medical Center Schleswig-Holstein, Campus Luebeck, Germany.
Engel S; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Faldum A; Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany.
Fröhlich B; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Gadner H; St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
Göbel U; Clinic of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, Duesseldorf, Germany.
Gosheger G; Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
Hardes J; Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
Hawkins DS; Seattle Children's Hospital and Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA.
Hjorth L; Skåne University Hospital, Lund University, Lund, Sweden.
Hoffmann C; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Kovar H; St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
Kruseova J; Department of Paediatric Haematology and Oncology Charles University, 2nd School of Medicine, Prague, Czech Republic.
Ladenstein R; St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
Leuschner I; Kiel Paediatric Tumor Registry, Department of Paediatric Pathology, Christian-Albrechts-University Kiel, Kiel, Germany.
Lewis IJ; Alder Hey Children's National Health Service Foundation Trust, Liverpool, UK.
Oberlin O; Gustave Roussy Institute, Villejuif, France.
Paulussen M; Vestische Kinder-und Jugendklinik Datteln, Witten/Herdecke University, Datteln, Germany.
Potratz J; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Ranft A; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Rössig C; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Rübe C; Department of Radiotherapy and Radiation Oncology, Saarland University Medical Center, Homburg, Germany.
Sauer R; Department of Radiation Therapy, University of Erlangen, Erlangen, Germany.
Schober O; Department of Nuclear Medicine, University of Münster, Münster, Germany.
Schuck A; Department of Radiotherapy, University Hospital Muenster, Muenster, Germany.
Timmermann B; Clinic for Particle Therapy, West German Proton Therapy Center Essen, West German Cancer Center, University Hospital Essen.
Tirode F; Inserm U830, Laboratory of Genetics and Biology of Cancers, Institut Curie, Paris, France.
van den Berg H; Emma Children Hospital AMC, University of Amsterdam, Amsterdam, the Netherlands.
van Valen F; Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany.
Vieth V; Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
Willich N; Department of Radiotherapy, University Hospital Muenster, Muenster, Germany.
Winkelmann W; Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
Whelan J; NIHR University College London Hospitals Biomedical Research Centre, London, UK.
Womer RB; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
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Źródło :
Klinische Padiatrie [Klin Padiatr] 2015 May; Vol. 227 (3), pp. 108-15. Date of Electronic Publication: 2015 May 18.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Ferdinand Enke Verlag Country of Publication: Germany NLM ID: 0326144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-3824 (Electronic) Linking ISSN: 03008630 NLM ISO Abbreviation: Klin Padiatr Subsets: MEDLINE
MeSH Terms :
Cooperative Behavior*
Interdisciplinary Communication*
Bone Neoplasms/*therapy
Sarcoma, Ewing/*therapy
Soft Tissue Neoplasms/*therapy
Antineoplastic Combined Chemotherapy Protocols ; Bone Neoplasms/mortality ; Child ; Clinical Trials as Topic ; Combined Modality Therapy ; Disease Progression ; Humans ; Neoadjuvant Therapy ; Osteotomy ; Radiotherapy, Adjuvant ; Sarcoma, Ewing/mortality ; Soft Tissue Neoplasms/mortality ; Survival Rate
Czasopismo naukowe
Tytuł :
Ewing-like sarcomas with BCOR-CCNB3 fusion transcript: a clinical, radiological and pathological retrospective study from the Société Française des Cancers de L'Enfant.
Autorzy :
Cohen-Gogo S; INSERM U830, Institut Curie - Research Center, 26 rue d'Ulm, Paris, Cedex 5, France.
Cellier C
Coindre JM
Mosseri V
Pierron G
Guillemet C
Italiano A
Brugières L
Orbach D
Laurence V
Delattre O
Michon J
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2014 Dec; Vol. 61 (12), pp. 2191-8. Date of Electronic Publication: 2014 Aug 31.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: John Wiley Country of Publication: United States NLM ID: 101186624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-5017 (Electronic) Linking ISSN: 15455009 NLM ISO Abbreviation: Pediatr Blood Cancer Subsets: MEDLINE
MeSH Terms :
Gene Fusion*
Bone Neoplasms/*pathology
Cyclin B/*genetics
Lung Neoplasms/*secondary
Proto-Oncogene Proteins/*genetics
Repressor Proteins/*genetics
Sarcoma, Ewing/*secondary
Adolescent ; Adult ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/genetics ; Child ; Combined Modality Therapy ; Female ; Follow-Up Studies ; France ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/genetics ; Male ; Neoplasm Staging ; Prognosis ; Radiography ; Retrospective Studies ; Sarcoma, Ewing/diagnostic imaging ; Sarcoma, Ewing/genetics ; Survival Rate ; Young Adult
Czasopismo naukowe
Tytuł :
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.
Autorzy :
Tirode F; INSERM U830, Laboratory of Genetics and Cancer Biology, Institut Curie, Paris, France. Centre de Recherche, Institut Curie, Paris, France.
Surdez D; INSERM U830, Laboratory of Genetics and Cancer Biology, Institut Curie, Paris, France. Centre de Recherche, Institut Curie, Paris, France.
Ma X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Parker M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Le Deley MC; Departement d'Epidémiologie et de Biostatistiques, Gustave Roussy, Villejuif, France.
Bahrami A; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Zhang Z; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Lapouble E; Unité de Génétique Somatique, Centre Hospitalier, Institut Curie, Paris, France.
Grossetête-Lalami S; INSERM U830, Laboratory of Genetics and Cancer Biology, Institut Curie, Paris, France. Centre de Recherche, Institut Curie, Paris, France.
Rusch M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Reynaud S; Unité de Génétique Somatique, Centre Hospitalier, Institut Curie, Paris, France.
Rio-Frio T; Centre de Recherche, Institut Curie, Paris, France.
Hedlund E; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Wu G; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Chen X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Pierron G; Unité de Génétique Somatique, Centre Hospitalier, Institut Curie, Paris, France.
Oberlin O; Departement de Pédiatrie, Gustave Roussy, Villejuif, France.
Zaidi S; INSERM U830, Laboratory of Genetics and Cancer Biology, Institut Curie, Paris, France. Centre de Recherche, Institut Curie, Paris, France.
Lemmon G; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Gupta P; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Vadodaria B; The Pediatric Cancer Genome Laboratory, St. Jude Children's Research Hospital, Memphis, Tennessee.
Easton J; The Pediatric Cancer Genome Laboratory, St. Jude Children's Research Hospital, Memphis, Tennessee.
Gut M; Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain.
Ding L; Department of Genetics, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Department of Medicine, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Mardis ER; Department of Genetics, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Department of Medicine, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Wilson RK; Department of Genetics, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Department of Medicine, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Shurtleff S; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Laurence V; Département d'Oncologie Medicale, Adolescents et Jeunes Adultes, Centre Hospitalier, Institut Curie, Paris, France.
Michon J; Département d'Oncologie Pediatrique, Adolescents et Jeunes Adultes, Centre Hospitalier, Institut Curie, Paris, France.
Marec-Bérard P; Institute for Paediatric Haematology and Oncology, Leon Bérard Cancer Centre, University of Lyon, Lyon, France.
Gut I; Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain.
Downing J; The Pediatric Cancer Genome Laboratory, St. Jude Children's Research Hospital, Memphis, Tennessee.
Dyer M; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee. Howard Hughes Medical Institute, Chevy Chase, Maryland.
Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee. olivier.delattre@curie.fr .
Delattre O; INSERM U830, Laboratory of Genetics and Cancer Biology, Institut Curie, Paris, France. Centre de Recherche, Institut Curie, Paris, France. olivier.delattre@curie.fr .
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Corporate Authors :
St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project and the International Cancer Genome Consortium
Źródło :
Cancer discovery [Cancer Discov] 2014 Nov; Vol. 4 (11), pp. 1342-53. Date of Electronic Publication: 2014 Sep 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
MeSH Terms :
Antigens, Nuclear/*genetics
Bone Neoplasms/*genetics
Sarcoma, Ewing/*genetics
Tumor Suppressor Protein p53/*genetics
Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; DNA, Neoplasm/genetics ; Genomics ; Humans ; Mutation ; Prognosis ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis.
Autorzy :
Stoll G; Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 05, France, INSERM U900, Bioinformatique, biostatistique et épidémiologie d'un système complexe, Paris, France, Mines ParisTech, Fontainebleau, France, INSERM U830, Unité de Génétique et Biologie des Cancers, Paris, France and Institut Curie, Unité de génétique somatique, Paris, France.
Surdez D
Tirode F
Laud K
Barillot E
Zinovyev A
Delattre O
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2013 Oct; Vol. 41 (19), pp. 8853-71. Date of Electronic Publication: 2013 Aug 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res. Subsets: MEDLINE
MeSH Terms :
Cell Proliferation*
Gene Regulatory Networks*
Apoptosis/*genetics
Bone Neoplasms/*genetics
Oncogene Proteins, Fusion/*metabolism
Proto-Oncogene Protein c-fli-1/*metabolism
RNA-Binding Protein EWS/*metabolism
Sarcoma, Ewing/*genetics
Bone Neoplasms/metabolism ; Cell Line, Tumor ; Data Mining ; Gene Expression Regulation, Neoplastic ; Humans ; Models, Genetic ; Oncogene Proteins, Fusion/antagonists & inhibitors ; Oncogene Proteins, Fusion/genetics ; Proto-Oncogene Protein c-fli-1/antagonists & inhibitors ; Proto-Oncogene Protein c-fli-1/genetics ; RNA, Small Interfering/metabolism ; RNA-Binding Protein EWS/antagonists & inhibitors ; RNA-Binding Protein EWS/genetics ; Sarcoma, Ewing/metabolism ; Signal Transduction ; Systems Biology ; Transcriptome
Czasopismo naukowe
Tytuł :
MiR-30a-5p connects EWS-FLI1 and CD99, two major therapeutic targets in Ewing tumor.
Autorzy :
Franzetti GA; INSERM U830, Génétique et Biologie des cancers, Institut Curie, Centre de recherche, Paris, France.
Laud-Duval K
Bellanger D
Stern MH
Sastre-Garau X
Delattre O
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Źródło :
Oncogene [Oncogene] 2013 Aug 15; Vol. 32 (33), pp. 3915-21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
MeSH Terms :
Antigens, CD/*genetics
Bone Neoplasms/*genetics
Cell Adhesion Molecules/*genetics
Gene Expression Regulation, Neoplastic/*genetics
MicroRNAs/*genetics
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
12E7 Antigen ; Animals ; Antigens, CD/metabolism ; Blotting, Western ; Bone Neoplasms/metabolism ; Cell Adhesion Molecules/metabolism ; Cell Line, Tumor ; Flow Cytometry ; Fluorescent Antibody Technique ; Humans ; Immunohistochemistry ; Mice ; Mice, SCID ; MicroRNAs/metabolism ; Oligonucleotide Array Sequence Analysis ; Oncogene Proteins, Fusion/metabolism ; Proto-Oncogene Protein c-fli-1/metabolism ; RNA-Binding Protein EWS/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Sarcoma, Ewing/metabolism ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Oncostatin M is a growth factor for Ewing sarcoma.
Autorzy :
David E; INSERM, UMR, Ligue Team 2012, Nantes, France.
Tirode F
Baud'huin M
Guihard P
Laud K
Delattre O
Heymann MF
Heymann D
Redini F
Blanchard F
Pokaż więcej
Źródło :
The American journal of pathology [Am J Pathol] 2012 Nov; Vol. 181 (5), pp. 1782-95. Date of Electronic Publication: 2012 Sep 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am. J. Pathol. Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Bone Neoplasms/*metabolism
Bone Neoplasms/*pathology
Intercellular Signaling Peptides and Proteins/*metabolism
Oncostatin M/*metabolism
Sarcoma, Ewing/*metabolism
Sarcoma, Ewing/*pathology
Animals ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chondrosarcoma/metabolism ; Chondrosarcoma/pathology ; Cytokine Receptor gp130/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins/pharmacology ; Leukemia Inhibitory Factor/metabolism ; Mesoderm/drug effects ; Mesoderm/pathology ; Mice ; Models, Biological ; Oncogene Proteins, Fusion/metabolism ; Oncostatin M/pharmacology ; Osteosarcoma/metabolism ; Osteosarcoma/pathology ; Protein Subunits/metabolism ; Proto-Oncogene Protein c-fli-1/metabolism ; Proto-Oncogene Proteins c-myc/metabolism ; RNA-Binding Protein EWS/metabolism ; Receptors, OSM-LIF/metabolism ; Receptors, Oncostatin M/metabolism ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe

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