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Tytuł :
Age Dependency of the Prognostic Impact of Tumor Genomics in Localized Resectable MYCN -Nonamplified Neuroblastomas. Report From the SIOPEN Biology Group on the LNESG Trials and a COG Validation Group.
Autorzy :
Ambros IM; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
Tonini GP; Paediatric Research Institute, Fondazione Città della Speranza, Neuroblastoma Laboratory, Padua, Italy.
Pötschger U; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
Gross N; Pediatric Oncology Research, Department of Pediatrics, University Hospital, Lausanne, Switzerland.
Mosseri V; Service de Biostatistiques, Institut Curie, Paris, France.
Beiske K; Department of Pathology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Berbegall AP; Department of Pathology, Medical School, University of Valencia-Fundación de Investigación del Hospital Clínico Universitario de Valencia, Valencia, Spain.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.
Bénard J; Département de Biologie et de Pathologie Médicales, Service de Pathologie Moléculaire, Institut Gustave Roussy, Villejuif, France.
Bown N; Northern Genetics Service, Newcastle upon Tyne, United Kingdom.
Caron H; Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands.
Combaret V; Centre Léon Bérard, Laboratoire de Recherche Translationnelle, Lyon, France.
Couturier J; Unité de Génétique Somatique et Cytogénétique, Institut Curie, Paris, France.
Defferrari R; Department of Pathology, Istituto G. Gaslini, Genoa, Italy.
Delattre O; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Paris, France.
Jeison M; Ca-Cytogenetic Laboratory, Pediatric Hematology Oncology Department, Schneider Children's Medical Center of Israel, Petah Tikvah, Israel.
Kogner P; Childhood Cancer Research Unit, Karolinska Institutet, Astrid Lindgren Children's Hospital, Stockholm, Sweden.
Lunec J; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Marques B; Centro de Genética Humana, Instituto Nacional de Saude doutor Ricardo Jorge, Lisbon, Portugal.
Martinsson T; Department of Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, Göteborg, Sweden.
Mazzocco K; Department of Pathology, Istituto G. Gaslini, Genoa, Italy.
Noguera R; Department of Pathology, Medical School, University of Valencia-Fundación de Investigación del Hospital Clínico Universitario de Valencia, Valencia, Spain.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.
Schleiermacher G; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Paris, France.; Département de Pédiatrie, Institut Curie, Paris, France.
Valent A; Département de Biologie et de Pathologie Médicales, Service de Pathologie Moléculaire, Institut Gustave Roussy, Villejuif, France.
Van Roy N; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.
Villamon E; Department of Pathology, Medical School, University of Valencia-Fundación de Investigación del Hospital Clínico Universitario de Valencia, Valencia, Spain.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.
Janousek D; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
Pribill I; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
Glogova E; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
Attiyeh EF; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA.
Hogarty MD; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA.
Monclair TF; Section for Paediatric Surgery, Division of Surgery, Rikshospitalet University Hospital, Oslo, Norway.
Holmes K; Department of Paediatric Surgery, St George's Hospital, London, UK.
Valteau-Couanet D; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Villejuif, France.
Castel V; Unidad de Oncologia Pediatrica Hospital Universitario La Fe, Valencia, Spain.
Tweddle DA; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Park JR; Seattle Children's Hospital and University of Washington School of Medicine, Seattle, WA.
Cohn S; Department of Pediatrics, The University of Chicago, Chicago, IL.
Ladenstein R; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Beck-Popovic M; Pediatric Hematology Oncology Unit, University Hospital of Lausanne, Lausanne, Switzerland.
De Bernardi B; Department of Paediatric Haematology and Oncology, Giannina Gaslini Children's Hospital, Genova, Italy.
Michon J; Département de Pédiatrie, Institut Curie, Paris, France.
Pearson ADJ; Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, United Kingdom.
Ambros PF; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
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Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2020 Nov 01; Vol. 38 (31), pp. 3685-3697. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity.
Autorzy :
Manzella G; University Children's Hospital, Department of Oncology and Children's Research Center, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland.
Schreck LD; University Children's Hospital, Department of Oncology and Children's Research Center, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland.
Breunis WB; University Children's Hospital, Department of Oncology and Children's Research Center, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland.; Princess Máxima Center for Pediatric Oncology, Uppsalalaan 8, 3584, CT, Utrecht, The Netherlands.
Molenaar J; Princess Máxima Center for Pediatric Oncology, Uppsalalaan 8, 3584, CT, Utrecht, The Netherlands.
Merks H; Princess Máxima Center for Pediatric Oncology, Uppsalalaan 8, 3584, CT, Utrecht, The Netherlands.
Barr FG; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA.
Sun W; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA.
Römmele M; University Children's Hospital, Department of Oncology and Children's Research Center, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland.
Zhang L; University Children's Hospital, Department of Oncology and Children's Research Center, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland.
Tchinda J; University Children's Hospital, Department of Oncology and Children's Research Center, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland.
Ngo QA; University Children's Hospital, Department of Oncology and Children's Research Center, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland.
Bode P; University Hospital Zurich, Institute of Surgical Pathology, Schmelzbergstrasse 12, CH-8091, Zurich, Switzerland.
Delattre O; France INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Surdez D; France INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Rekhi B; Tata Memorial Hospital, Department of Pathology, Dr E.B. road, Parel, Mumbai, 400012, India.
Niggli FK; University Children's Hospital, Department of Oncology and Children's Research Center, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland.
Schäfer BW; University Children's Hospital, Department of Oncology and Children's Research Center, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland. .
Wachtel M; University Children's Hospital, Department of Oncology and Children's Research Center, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland.
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Źródło :
Nature communications [Nat Commun] 2020 Sep 15; Vol. 11 (1), pp. 4629. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Drug Screening Assays, Antitumor/*methods
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
Rhabdomyosarcoma/*metabolism
Animals ; Biological Specimen Banks ; Gene Expression Profiling ; Humans ; Phenotype ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Rhabdomyosarcoma/drug therapy ; Rhabdomyosarcoma/genetics ; Tumor Cells, Cultured/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Low-frequency variation near common germline susceptibility loci are associated with risk of Ewing sarcoma.
Autorzy :
Lin SH; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Sampson JN; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Ludwig Maximilians Universität (LMU), Munich, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Surdez D; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, Paris, France.
Reynaud S; SIREDO Oncology Centre, Institut Curie, Paris, France.
Mirabeau O; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, Paris, France.; SIREDO Oncology Centre, Institut Curie, Paris, France.
Karlins E; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, United States of America.
Rubio RA; Max-Eder Research Group for Pediatric Sarcoma Biology, Ludwig Maximilians Universität (LMU), Munich, Germany.
Zaidi S; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, Paris, France.; SIREDO Oncology Centre, Institut Curie, Paris, France.
Grossetête-Lalami S; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, Paris, France.; SIREDO Oncology Centre, Institut Curie, Paris, France.
Ballet S; SIREDO Oncology Centre, Institut Curie, Paris, France.
Lapouble E; SIREDO Oncology Centre, Institut Curie, Paris, France.
Laurence V; SIREDO Oncology Centre, Institut Curie, Paris, France.
Michon J; SIREDO Oncology Centre, Institut Curie, Paris, France.
Pierron G; SIREDO Oncology Centre, Institut Curie, Paris, France.
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Kontny U; Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Uniklinik RWTH Aachen, Aachen, Germany.
González-Neira A; Human Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain.
Alonso J; Unidad de Tumores Solidos Infantiles (IIER-ISCIII) & Centro de Investigación Biomédica en Red de Enfermedades Raras (CB06/07/1009; CIBERER-ISCIII), Instituto de Salud Carlos III, Majadahonda, Spain.
Patino-Garcia A; Laboratory of Pediatrics, University Clinic of Navarra, Program in Solid Tumors, Center for Applied Medical Research (CIMA) and Navarra's Health Research Institute (IdiSNA), Pamplona, Spain.
Corradini N; Institute for Paediatric Haematology and Oncology, Leon Bérard Cancer Centre, University of Lyon, Lyon, France.
Bérard PM; Institute for Paediatric Haematology and Oncology, Leon Bérard Cancer Centre, University of Lyon, Lyon, France.
Miller J; Information Management Services, Inc., Calverton, MD, United States of America.
Freedman ND; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Rothman N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Carter BD; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, United States of America.
Dagnall CL; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, United States of America.
Burdett L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, United States of America.
Jones K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, United States of America.
Manning M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, United States of America.
Wyatt K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, United States of America.
Zhou W; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, United States of America.
Yeager M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, United States of America.
Cox DG; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Hoover RN; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Khan J; Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States of America.
Armstrong GT; Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, United States of America.
Leisenring WM; Cancer Prevention and Clinical Statistics Programs, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.
Bhatia S; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Robison LL; Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, United States of America.
Kulozik AE; Department of Pediatric Oncology, Hematology and Immunology and Hopp Children Cancer Center, University of Heidelberg, Heidelberg, Germany.
Kriebel J; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München, Neuherberg, Germany.
Meitinger T; German Research Center for Environmental Health, Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany.
Metzler M; Department of Paediatrics and Adolescent Medicine, University Hospital of Erlangen, Erlangen, Germany.
Krumbholz M; Department of Paediatrics and Adolescent Medicine, University Hospital of Erlangen, Erlangen, Germany.
Hartmann W; Division of Translational Pathology, Gerhard-Domagk Institute of Pathology, University Hospital of Münster, Münster, Germany.
Strauch K; Institute of Genetic Epidemiology, LMU Munich, Munich, Germany.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Dirksen U; Pediatrics III, West German Cancer Centre, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), Center Essen, Heidelberg, Germany.
Mirabello L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Tucker MA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Tirode F; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, Paris, France.; SIREDO Oncology Centre, Institut Curie, Paris, France.
Morton LM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Delattre O; Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie, Paris, France.; SIREDO Oncology Centre, Institut Curie, Paris, France.
Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Sep 03; Vol. 15 (9), pp. e0237792. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Loci*
Genetic Predisposition to Disease*
Genetic Variation*
Germ Cells/*metabolism
Sarcoma, Ewing/*genetics
Genome-Wide Association Study ; Humans ; Linkage Disequilibrium/genetics ; Odds Ratio ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
The usefulness of a short stay geriatric unit post emergency department for the facilitation of in-hospital care of elderly subjects.
Autorzy :
Moyet J; Departments of Geriatric Medicine.
Douay B; Emergency.
Delattre O; Departments of Geriatric Medicine.
Hannat S; Departments of Geriatric Medicine.
Defouilloy C; Departments of Geriatric Medicine.
Bloch F; Departments of Geriatric Medicine.; Laboratory of Functional Neurosciences EA 4559, University Hospital of Amiens-Picardie, Amiens, France.
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Źródło :
European journal of emergency medicine : official journal of the European Society for Emergency Medicine [Eur J Emerg Med] 2020 Jun; Vol. 27 (3), pp. 230-231.
Typ publikacji :
Letter
Opinia redakcyjna
Tytuł :
Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors.
Autorzy :
Theruvath J; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Sotillo E; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Mount CW; Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.
Graef CM; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Delaidelli A; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.
Heitzeneder S; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Labanieh L; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Dhingra S; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Leruste A; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Majzner RG; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Xu P; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Mueller S; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Yecies DW; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Finetti MA; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Williamson D; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Johann PD; Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center and German Cancer Consortium, Heidelberg, Germany.; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Kool M; Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center and German Cancer Consortium, Heidelberg, Germany.
Pfister S; Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center and German Cancer Consortium, Heidelberg, Germany.; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Hasselblatt M; Institute of Neuropathology, Münster University Hospital, Münster, Germany.
Frühwald MC; University Children's Hospital Augsburg, Swabian Children's Cancer Center, Augsburg, Germany.; EU-RHAB Registry Center, Augsburg, Germany.
Delattre O; Paris Sciences Lettres Research University, INSERM U830, Paris, France.; Paris Sciences Lettres Research University, SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Surdez D; Paris Sciences Lettres Research University, INSERM U830, Paris, France.; Paris Sciences Lettres Research University, SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Bourdeaut F; Paris Sciences Lettres Research University, INSERM U830, Paris, France.; Paris Sciences Lettres Research University, SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Puget S; Paris University, Necker-Enfants Malades Hospital, Department of Neurosurgery, Assistance Publique-Hôpitaux de Paris, Paris, France.
Zaidi S; Paris Sciences Lettres Research University, INSERM U830, Paris, France.; Paris Sciences Lettres Research University, SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Mitra SS; Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Cheshier S; Division of Pediatric Neurosurgery, Department of Neurosurgery, Primary Children's Hospital and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Sorensen PH; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.
Monje M; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Institute for Stem Cell and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Mackall CL; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. .; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. .; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. .
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Źródło :
Nature medicine [Nat Med] 2020 May; Vol. 26 (5), pp. 712-719. Date of Electronic Publication: 2020 Apr 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B7 Antigens/*immunology
Brain Neoplasms/*therapy
Cancer Vaccines/*administration & dosage
Immunotherapy, Adoptive/*methods
Rhabdoid Tumor/*therapy
Teratoma/*therapy
Adult ; Animals ; Brain/drug effects ; Brain/immunology ; Brain/pathology ; Brain Neoplasms/immunology ; Brain Neoplasms/pathology ; Cells, Cultured ; Child, Preschool ; Female ; Fetus/pathology ; Humans ; Infant ; Injections, Intraventricular ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Receptors, Chimeric Antigen/administration & dosage ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/immunology ; Rhabdoid Tumor/immunology ; Rhabdoid Tumor/pathology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/transplantation ; Teratoma/immunology ; Teratoma/pathology ; Xenograft Model Antitumor Assays
SCR Disease Name :
Teratoid Tumor, Atypical
Czasopismo naukowe
Tytuł :
ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin.
Autorzy :
Tanaka I; Institut Curie, PSL Research University, CNRS UMR 3348, F-91405 Orsay, France.; Paris Sud University, Paris-Saclay University, CNRS UMR 3348, F-91405 Orsay, France.; Equipe Labellisée Ligue Contre le Cancer.
Chakraborty A; Institut Curie, PSL Research University, CNRS UMR 3348, F-91405 Orsay, France.; Paris Sud University, Paris-Saclay University, CNRS UMR 3348, F-91405 Orsay, France.; Equipe Labellisée Ligue Contre le Cancer.
Saulnier O; Institut Curie Research Center, SIREDO Oncology Center, Paris-Sciences-Lettres Research University, INSERM U830, Laboratory of Biology and Genetics of Cancers, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, France.
Benoit-Pilven C; CNRS UMR 5239, Ecole Normale Supérieure de Lyon, Lyon, France.
Vacher S; Unité de Pharmacogénomique, Service de génétique, Institut Curie, Paris, France; Université Paris Descartes, Paris, France.
Labiod D; Paris Sud University, Paris-Saclay University, CNRS UMR 3348, F-91405 Orsay, France.; Institut Curie, PSL Research University, Translational Research Department, Experimental Radiotherapy Platform, Orsay, France.
Lam EWF; Imperial College London, London, UK.
Bièche I; Unité de Pharmacogénomique, Service de génétique, Institut Curie, Paris, France; Université Paris Descartes, Paris, France.
Delattre O; Institut Curie Research Center, SIREDO Oncology Center, Paris-Sciences-Lettres Research University, INSERM U830, Laboratory of Biology and Genetics of Cancers, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, France.
Pouzoulet F; Paris Sud University, Paris-Saclay University, CNRS UMR 3348, F-91405 Orsay, France.; Institut Curie, PSL Research University, Translational Research Department, Experimental Radiotherapy Platform, Orsay, France.
Auboeuf D; CNRS UMR 5239, Ecole Normale Supérieure de Lyon, Lyon, France.
Vagner S; Institut Curie, PSL Research University, CNRS UMR 3348, F-91405 Orsay, France.; Paris Sud University, Paris-Saclay University, CNRS UMR 3348, F-91405 Orsay, France.; Equipe Labellisée Ligue Contre le Cancer.
Dutertre M; Institut Curie, PSL Research University, CNRS UMR 3348, F-91405 Orsay, France.; Paris Sud University, Paris-Saclay University, CNRS UMR 3348, F-91405 Orsay, France.; Equipe Labellisée Ligue Contre le Cancer.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Mar 18; Vol. 48 (5), pp. 2676-2693.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*/drug effects
Drug Resistance, Neoplasm*/genetics
Alternative Splicing/*genetics
Breast Neoplasms/*drug therapy
Doxorubicin/*therapeutic use
Proto-Oncogene Proteins/*metabolism
RNA-Binding Proteins/*metabolism
Adult ; Aged ; Aged, 80 and over ; Alternative Splicing/drug effects ; Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Doxorubicin/pharmacology ; Epithelial-Mesenchymal Transition/drug effects ; Epithelial-Mesenchymal Transition/genetics ; Exons/genetics ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MCF-7 Cells ; Mice, Nude ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged ; Protein Isoforms/metabolism ; RNA Splice Sites/genetics ; S Phase/drug effects ; Spliceosomes/metabolism
Czasopismo naukowe
Tytuł :
High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma.
Autorzy :
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Department of Pediatrics, University Hospital Münster, 48149 Münster, Germany.
Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Paul T; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Surdez D; INSERM Unit 830 'Genetics and Biology of Cancers', Institut Curie Research Center, 75248 Paris, France.
Delattre O; INSERM Unit 830 'Genetics and Biology of Cancers', Institut Curie Research Center, 75248 Paris, France.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Kasan M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Henssen AG; Department of Pediatric Hematology/Oncology/BMT, Charité-University Medicine Berlin, 13353 Berlin, Germany.; Experimental and Clinical Research Center (ECRC) of the MDC and Charité Berlin, 13125 Berlin, Germany.
Özen Ö; Department of Pathology, Başkent University Hospital, 06490 Ankara, Turkey.
Sugita S; Department of Surgical Pathology, Sapporo Medical University, 060-8556 Sapporo, Japan.
Hasegawa T; Department of Surgical Pathology, Sapporo Medical University, 060-8556 Sapporo, Japan.
Kanaseki T; Department of Pathology, Sapporo Medical University, 060-8556 Sapporo, Japan.
Bertram S; Institute of Pathology, University Hospital Essen, 45147 Essen, Germany.
Dirksen U; Pediatrics III, AYA Unit, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), Partner site Essen, 45147 Essen, Germany.
Hartmann W; Division of Translational Oncology, Gerhard-Domagk-Institute for Pathology, University Hospital Münster, 48149 Münster, Germany.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; German Cancer Consortium (DKTK), Partner site Munich, 80336 Munich, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; German Cancer Consortium (DKTK), Partner site Munich, 80336 Munich, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
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Źródło :
Cancers [Cancers (Basel)] 2020 Mar 10; Vol. 12 (3). Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
High CD44 expression is not a prognosis marker in patients with high-risk neuroblastoma.
Autorzy :
Louis-Brennetot C; Inserm U830, Institut Curie, PSL Research University, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France.
Delattre O; Inserm U830, Institut Curie, PSL Research University, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France.
Janoueix-Lerosey I; Inserm U830, Institut Curie, PSL Research University, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France. Electronic address: .
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Źródło :
EBioMedicine [EBioMedicine] 2020 Mar; Vol. 53, pp. 102702. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Neural Crest*
Neuroblastoma*
Humans ; Hyaluronan Receptors ; Prognosis
Czasopismo naukowe
Tytuł :
Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death.
Autorzy :
Ommer J; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Selfe JL; Sarcoma Molecular Pathology Laboratory, The Institute of Cancer Research, London, United Kingdom.
Wachtel M; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
O'Brien EM; Sarcoma Molecular Pathology Laboratory, The Institute of Cancer Research, London, United Kingdom.
Laubscher D; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Roemmele M; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Kasper S; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Delattre O; France INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Surdez D; France INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Petts G; Department of Diagnostic Paediatric Histopathology, Royal Manchester Children's Hospital, Manchester, United Kingdom.
Kelsey A; Department of Diagnostic Paediatric Histopathology, Royal Manchester Children's Hospital, Manchester, United Kingdom.
Shipley J; Sarcoma Molecular Pathology Laboratory, The Institute of Cancer Research, London, United Kingdom.
Schäfer BW; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. .
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Źródło :
Cancer research [Cancer Res] 2020 Feb 15; Vol. 80 (4), pp. 832-842. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Aurora Kinase A/*metabolism
N-Myc Proto-Oncogene Protein/*metabolism
Oncogene Proteins, Fusion/*metabolism
Paired Box Transcription Factors/*metabolism
Rhabdomyosarcoma, Alveolar/*drug therapy
Aniline Compounds/pharmacology ; Aniline Compounds/therapeutic use ; Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis/drug effects ; Aurora Kinase A/antagonists & inhibitors ; Drug Synergism ; Gene Knockdown Techniques ; HEK293 Cells ; Humans ; Mice ; Mutagenesis, Site-Directed ; Oncogene Proteins, Fusion/genetics ; Paired Box Transcription Factors/genetics ; Phosphorylation/drug effects ; Primary Cell Culture ; Protein Stability/drug effects ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Small Interfering/metabolism ; Rhabdomyosarcoma, Alveolar/genetics ; Rhabdomyosarcoma, Alveolar/pathology ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution.
Autorzy :
Aynaud MM; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Mirabeau O; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Gruel N; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France; Institut Curie, PSL Research University, Department of Translational Research, 75005 Paris, France.
Grossetête S; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Boeva V; Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes UMR-S1016, 75014 Paris, France; Department of Computer Science, Institute for Machine Learning, Swiss Institute of Bioinformatics (SIB), ETH Zurich, 8092 Zurich, Switzerland; INSERM U900, 75005 Paris, France; Mines ParisTech, PSL Research University, CBIO-Centre for Computational Biology, 75006 Paris, France; Institut Curie, PSL Research University, 75005 Paris, France.
Durand S; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Surdez D; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Saulnier O; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Zaïdi S; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Gribkova S; INSERM U900, 75005 Paris, France; Mines ParisTech, PSL Research University, CBIO-Centre for Computational Biology, 75006 Paris, France; Institut Curie, PSL Research University, 75005 Paris, France; Université Denis Diderot, 75013, Paris, France.
Fouché A; École Normale Supérieure Paris-Saclay, 94230 Cachan, France.
Kairov U; Laboratory of Bioinformatics and Systems Biology, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan.
Raynal V; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Tirode F; University of Lyon, Université Claude Bernard Lyon 1, CNRS 5286, INSERM U1052, Cancer Research Centre of Lyon, 69008 Lyon, France.
Grünewald TGP; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France; Institut Curie, PSL Research University, Department of Translational Research, 75005 Paris, France.
Bohec M; NGS Platform, Institut Curie, 75005 Paris, France.
Baulande S; NGS Platform, Institut Curie, 75005 Paris, France.
Janoueix-Lerosey I; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Vert JP; Mines ParisTech, PSL Research University, CBIO-Centre for Computational Biology, 75006 Paris, France; Google Research, Brain Team, 75009 Paris, France.
Barillot E; INSERM U900, 75005 Paris, France; Mines ParisTech, PSL Research University, CBIO-Centre for Computational Biology, 75006 Paris, France; Institut Curie, PSL Research University, 75005 Paris, France.
Delattre O; INSERM U830, Équipe Labellisée LNCC, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France. Electronic address: olivier.delattre@curie.fr.
Zinovyev A; INSERM U900, 75005 Paris, France; Mines ParisTech, PSL Research University, CBIO-Centre for Computational Biology, 75006 Paris, France; Institut Curie, PSL Research University, 75005 Paris, France. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2020 Feb 11; Vol. 30 (6), pp. 1767-1779.e6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Association of Partial Chromosome 3 Deletion in Uveal Melanomas With Metastasis-Free Survival.
Autorzy :
Rodrigues M; Unit 830 (Cancer, Heterogeneity, Instability and Plasticity) INSERM, Institut Curie, PSL Research University, Paris, France.; Department of Medical Oncology, Institut Curie, PSL Research University, Paris, France.
Ait Rais K; Department of Genetics, Institut Curie, PSL Research University, Paris, France.
Salviat F; Department of Biometry, Institut Curie, PSL Research University, Paris, France.
Algret N; Department of Biometry, Institut Curie, PSL Research University, Paris, France.
Simaga F; Department of Genetics, Institut Curie, PSL Research University, Paris, France.
Barnhill R; Department of Biopathology, Institut Curie, PSL Research University, Paris, France.; Faculty of Medicine, University of Paris Descartes, Paris, France.
Gardrat S; Unit 830 (Cancer, Heterogeneity, Instability and Plasticity) INSERM, Institut Curie, PSL Research University, Paris, France.; Department of Biopathology, Institut Curie, PSL Research University, Paris, France.
Servois V; Department of Medical Imaging, Institut Curie, PSL Research University, Paris, France.
Mariani P; Department of Surgical Oncology, Institut Curie, PSL Research University, Paris, France.
Piperno-Neumann S; Department of Medical Oncology, Institut Curie, PSL Research University, Paris, France.
Roman-Roman S; Department of Translational Research, Institut Curie, PSL Research University, Paris, France.
Delattre O; Unit 830 (Cancer, Heterogeneity, Instability and Plasticity) INSERM, Institut Curie, PSL Research University, Paris, France.; Department of Genetics, Institut Curie, PSL Research University, Paris, France.
Cassoux N; Faculty of Medicine, University of Paris Descartes, Paris, France.; Department of Ocular Oncology, Institut Curie, PSL Research University, Paris, France.
Savignoni A; Department of Biometry, Institut Curie, PSL Research University, Paris, France.
Stern MH; Unit 830 (Cancer, Heterogeneity, Instability and Plasticity) INSERM, Institut Curie, PSL Research University, Paris, France.; Department of Genetics, Institut Curie, PSL Research University, Paris, France.
Pierron G; Department of Genetics, Institut Curie, PSL Research University, Paris, France.
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Źródło :
JAMA ophthalmology [JAMA Ophthalmol] 2020 Feb 01; Vol. 138 (2), pp. 182-188.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Deletion*
Chromosomes, Human, Pair 3*
Melanoma/*genetics
Uveal Neoplasms/*genetics
Adolescent ; Adult ; Aged ; Child ; Female ; Genetic Loci ; Humans ; Male ; Melanoma/mortality ; Middle Aged ; Neoplasm Metastasis ; Retrospective Studies ; Tumor Suppressor Proteins/genetics ; Ubiquitin Thiolesterase/genetics ; Uveal Neoplasms/mortality ; Young Adult
SCR Disease Name :
Uveal melanoma
Czasopismo naukowe
Tytuł :
Loss of SMARCB1 expression in colon carcinoma.
Autorzy :
Melloul S; Department of Pathology, Ambroise Paré Hospital, APHP, Boulogne, France.
Mosnier JF; Department of Pathology, Hotel Dieu, Nantes, France.
Masliah-Planchon J; Somatic Genetic Unit, Institut Curie, Paris, France.; Paris-Sciences-Lettres, Institut Curie Research Center, INSERMU830, Paris, France.; SIREDO, Institut Curie, Paris, France.
Lepage C; François Mitterrand University Hospital, Dijon, France.; EPICAD INSERM LNC-UMR 1231, University of Burgundy and Franche-Comté, Besançon, France.
Le Malicot K; EPICAD INSERM LNC-UMR 1231, University of Burgundy and Franche-Comté, Besançon, France.; Francophone Society of Digestive Cancer, Dijon, France.
Gornet JM; St Louis Hospital, APHP, Paris, France.
Edeline J; Eugène Marquis Center, Rennes, France.
Dansette D; Department of Pathology, Hotel Dieu, Nantes, France.
Texereau P; Layne Hospital Center, Mont-de-Marsan, France.
Delattre O; Somatic Genetic Unit, Institut Curie, Paris, France.; Paris-Sciences-Lettres, Institut Curie Research Center, INSERMU830, Paris, France.; SIREDO, Institut Curie, Paris, France.
Laurent Puig P; G. Pompidou European Hospital, APHP, Paris, France.; INSERM UMR-S1147, Paris, France.
Taieb J; G. Pompidou European Hospital, APHP, Paris, France.; INSERM UMR-S1147, Paris, France.
Emile JF; Department of Pathology, Ambroise Paré Hospital, APHP, Boulogne, France.; EA4340-BCOH, Versailles SQY University, Paris-Saclay University, Boulogne, France.
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Źródło :
Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2020; Vol. 27 (3), pp. 399-406.
Typ publikacji :
Journal Article
MeSH Terms :
Colonic Neoplasms/*metabolism
SMARCB1 Protein/*deficiency
Adult ; Aged ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Staging ; SMARCB1 Protein/biosynthesis ; SMARCB1 Protein/genetics ; SMARCB1 Protein/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors.
Autorzy :
Leruste A; PSL Research University, Institut Curie Research Center, INSERM U830, Paris, France; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Tosello J; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France.
Ramos RN; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France.
Tauziède-Espariat A; Sainte-Anne Hospital, Department of Neuropathology, Paris, France.
Brohard S; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Han ZY; PSL Research University, Institut Curie Research Center, INSERM U830, Paris, France; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Beccaria K; AP-HP, Necker Hospital, Department of Neurosurgery, Paris, France.
Andrianteranagna M; PSL Research University, Institut Curie Research Center, INSERM U900, Paris, France; MINES ParisTech, PSL Research University, CBIO-Centre for Computational Biology, Paris, France.
Caudana P; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France.
Nikolic J; PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France.
Chauvin C; PSL Research University, Institut Curie Research Center, INSERM U830, Paris, France; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Niborski LL; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France.
Manriquez V; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France.
Richer W; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France.
Masliah-Planchon J; PSL Research University, Institut Curie Hospital, Laboratory of Somatic Genetics, Paris, France.
Grossetête-Lalami S; PSL Research University, Institut Curie Research Center, INSERM U830, Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Bohec M; PSL Research University, Institut Curie Genomics of Excellence (ICGex) Platform, Paris, France.
Lameiras S; PSL Research University, Institut Curie Genomics of Excellence (ICGex) Platform, Paris, France.
Baulande S; PSL Research University, Institut Curie Genomics of Excellence (ICGex) Platform, Paris, France.
Pouponnot C; PSL Research University, Institut Curie Research Center, CNRS UMR 3347, INSERM U1021, Orsay, France.
Coulomb A; AP-HP, Armand Trousseau Hospital, Department of Pathology, Paris, France.
Galmiche L; AP-HP, Necker Hospital, Department of Pathology, Paris, France.
Surdez D; PSL Research University, Institut Curie Research Center, INSERM U830, Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Servant N; PSL Research University, Institut Curie Research Center, INSERM U900, Paris, France; MINES ParisTech, PSL Research University, CBIO-Centre for Computational Biology, Paris, France.
Helft J; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France.
Sedlik C; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France.
Puget S; AP-HP, Necker Hospital, Department of Neurosurgery, Paris, France.
Benaroch P; PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France.
Delattre O; PSL Research University, Institut Curie Research Center, INSERM U830, Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Waterfall JJ; PSL Research University, Institut Curie Research Center, INSERM U830, Paris, France; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France. Electronic address: .
Piaggio E; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; PSL Research University, Institut Curie Research Center, INSERM U932, Paris, France. Electronic address: .
Bourdeaut F; PSL Research University, Institut Curie Research Center, INSERM U830, Paris, France; PSL Research University, Institut Curie Research Center, Translational Research Department, Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France. Electronic address: .
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Źródło :
Cancer cell [Cancer Cell] 2019 Dec 09; Vol. 36 (6), pp. 597-612.e8. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin Assembly and Disassembly/*immunology
Rhabdoid Tumor/*genetics
Rhabdoid Tumor/*immunology
T-Lymphocytes/*immunology
Animals ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/immunology ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/immunology ; Humans ; Immunohistochemistry/methods ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation/genetics ; Nuclear Proteins/genetics ; Transcription Factors/genetics ; Transcription Factors/immunology
Czasopismo naukowe
Tytuł :
Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis.
Autorzy :
El-Naggar AM; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.; Department of Pathology, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt.
Somasekharan SP; Vancouver Prostate Centre, Vancouver, BC, Canada.
Wang Y; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Cheng H; Vancouver Prostate Centre, Vancouver, BC, Canada.
Negri GL; Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Pan M; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Wang XQ; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Delaidelli A; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Rafn B; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Cran J; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Zhang F; Vancouver Prostate Centre, Vancouver, BC, Canada.
Zhang H; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Colborne S; Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Gleave M; Vancouver Prostate Centre, Vancouver, BC, Canada.
Mandinova A; Brigham and Women's Hospital, Harvard University, Boston, MA, USA.
Kedersha N; Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Hughes CS; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Surdez D; Centre de recherche de l'Institut Curie, Paris, France.
Delattre O; Centre de recherche de l'Institut Curie, Paris, France.
Wang Y; Vancouver Prostate Centre, Vancouver, BC, Canada.
Huntsman DG; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Morin GB; Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Sorensen PH; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
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Źródło :
EMBO reports 2019 Dec 05; Vol. 20 (12), pp. e48375. Date of Electronic Publication: 2019 Oct 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Benzamides/*therapeutic use
Bone Neoplasms/*drug therapy
Histone Deacetylase Inhibitors/*therapeutic use
Pyridines/*therapeutic use
Sarcoma, Ewing/*drug therapy
Transcription Factors/*metabolism
Acetylation ; Animals ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cells, Cultured ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mice ; NF-E2-Related Factor 2/metabolism ; Neoplasm Metastasis ; Oxidative Stress ; Sarcoma, Ewing/metabolism ; Sarcoma, Ewing/pathology
Czasopismo naukowe
Tytuł :
Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.
Autorzy :
Bellini A; Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Bessoltane-Bentahar N; Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Bhalshankar J; Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Clement N; Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Raynal V; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.; Plateforme de Séquençage ICGex, Institut Curie, Paris, France.
Baulande S; Institut Curie, PSL Research University, NGS Platform, Paris, France.
Bernard V; Department of Biopathology, Institut Curie, PSL Research University, Paris, France.
Danzon A; Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Chicard M; Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Colmet-Daage L; Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Pierron G; Unité de Génétique Somatique, Institut Curie, Paris, France.
Le Roux L; Unité de Génétique Somatique, Institut Curie, Paris, France.
Planchon JM; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.; Department of Biopathology, Institut Curie, PSL Research University, Paris, France.
Combaret V; Laboratoire de Recherche Translationnelle, Centre Léon-Bérard, Lyon, France.
Lapouble E; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.; Unité de Génétique Somatique, Institut Curie, Paris, France.
Corradini N; Institut d'Hématologie et Oncologie Pédiatrique, Lyon, France.
Thebaud E; Service d'Oncologie Pédiatrique, Hôpital de la Mère et l'enfant, Nantes, France.
Gambart M; Unite d'Hemato-Oncologie, Hôpital des Enfants, Toulouse, France.
Valteau-Couanet D; Service d'Oncologie Pédiatrique, Institut Gustave Roussy, Paris, France.
Michon J; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Louis-Brennetot C; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.
Janoueix-Lerosey I; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.
Defachelles AS; Pediatric Oncology Unit, AntiCancer Center Oscar Lambret, Lille, France.
Bourdeaut F; Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Delattre O; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.; Unité de Génétique Somatique, Institut Curie, Paris, France.
Schleiermacher G; Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
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Źródło :
International journal of cancer [Int J Cancer] 2019 Nov 15; Vol. 145 (10), pp. 2781-2791. Date of Electronic Publication: 2019 May 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis/*genetics
Chromatin Assembly and Disassembly/*genetics
DNA Helicases/*genetics
Neuroblastoma/*genetics
Nuclear Proteins/*genetics
Transcription Factors/*genetics
Adolescent ; Case-Control Studies ; Child ; Child, Preschool ; DNA Copy Number Variations ; Exons/genetics ; Female ; Germ-Line Mutation ; Humans ; INDEL Mutation ; Infant ; Infant, Newborn ; Kaplan-Meier Estimate ; Male ; Neuroblastoma/mortality ; Neuroblastoma/pathology ; Polymorphism, Single Nucleotide ; Progression-Free Survival ; Whole Exome Sequencing ; X-linked Nuclear Protein/genetics
Czasopismo naukowe
Tytuł :
Same-stage total knee arthroplasty and osteotomy for osteoarthritis with extra-articular deformity. Part II: Femoral osteotomy, prospective study of 6 cases.
Autorzy :
Catonné Y; Hôpital Pitié-Salpêtrière, 47, boulevard de l'hôpital, 75013 Paris, France; Université Pierre et Marie Curie (Paris VI), 75013 Paris, France; Clinique Jouvenet, 6, square Jouvenet, 75016 Paris, France. Electronic address: .
Khiami F; Hôpital Pitié-Salpêtrière, 47, boulevard de l'hôpital, 75013 Paris, France; Université Pierre et Marie Curie (Paris VI), 75013 Paris, France.
Sariali E; Hôpital Pitié-Salpêtrière, 47, boulevard de l'hôpital, 75013 Paris, France; Université Pierre et Marie Curie (Paris VI), 75013 Paris, France.
Ettori MA; Hôpital Pitié-Salpêtrière, 47, boulevard de l'hôpital, 75013 Paris, France; Université Pierre et Marie Curie (Paris VI), 75013 Paris, France.
Delattre O; Centre Hospitalo Universitaire de Fort de France, 92000 Fort de France, Martinique.
Tillie B; Clinique Bon Secours, 62000 Arras, France.
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Źródło :
Orthopaedics & traumatology, surgery & research : OTSR [Orthop Traumatol Surg Res] 2019 Oct; Vol. 105 (6), pp. 1055-1060. Date of Electronic Publication: 2019 Jun 14.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Arthroplasty, Replacement, Knee/*methods
Femur/*surgery
Genu Valgum/*surgery
Genu Varum/*surgery
Osteoarthritis, Knee/*surgery
Osteotomy/*methods
Aged ; Ankle Joint ; Cohort Studies ; Female ; Genu Valgum/complications ; Genu Varum/complications ; Humans ; Knee Joint/physiopathology ; Knee Joint/surgery ; Male ; Middle Aged ; Osteoarthritis, Knee/complications ; Prospective Studies ; Radiography ; Range of Motion, Articular ; Tibia/surgery
Czasopismo naukowe
Tytuł :
ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma.
Autorzy :
Srivastava S; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Nataraj NB; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Sekar A; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Ghosh S; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Bornstein C; Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
Drago-Garcia D; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Roth L; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Romaniello D; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Marrocco I; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
David E; Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
Gilad Y; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Lauriola M; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
Rotkopf R; Department of Biological Services, Weizmann Institute of Science, Rehovot 76100, Israel.
Kimchi A; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Haga Y; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel; Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Tsutsumi Y; Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan; Global Center for Medical Engineering and Informatics, Osaka University, Japan.
Mirabeau O; PSL Research University, 'Genetics and Biology of Cancers' Unit, INSERM U830 and Unité Génétique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
Surdez D; PSL Research University, 'Genetics and Biology of Cancers' Unit, INSERM U830 and Unité Génétique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
Zinovyev A; Institut Curie, PSL Research University, INSERM U900, Mines ParisTech, Paris, France.
Delattre O; PSL Research University, 'Genetics and Biology of Cancers' Unit, INSERM U830 and Unité Génétique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
Kovar H; Children's Cancer Research Institute Vienna, St. Anna Kinderkrebsforschung and Department of Pediatrics, Medical University Vienna, Vienna, Austria.
Amit I; Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
Yarden Y; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Oct 01; Vol. 29 (1), pp. 104-117.e4.
Typ publikacji :
Journal Article
MeSH Terms :
Proto-Oncogene Proteins c-ets/*metabolism
Receptors, Glucocorticoid/*metabolism
Sarcoma, Ewing/*metabolism
Animals ; Bone Neoplasms/metabolism ; Cell Movement/physiology ; Cell Nucleus/metabolism ; Cell Proliferation/physiology ; Female ; Gene Expression Regulation, Neoplastic/physiology ; HEK293 Cells ; Humans ; Mice ; Mice, SCID ; Proto-Oncogene Protein c-fli-1/metabolism ; RNA-Binding Protein EWS/metabolism
Czasopismo naukowe
Tytuł :
Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes.
Autorzy :
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Aynaud MM; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Mirabeau O; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Mazor G; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Varon M; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Grossetête S; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Gartlgruber M; Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Surdez D; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Stein S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Westermann F; Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hartmann W; Division of Translational Pathology, Gerhard-Domagk Institute of Pathology, University Hospital of Münster, Münster, Germany.
Dirksen U; Department of Pediatric Hematology and Oncology, University Hospital of Essen, Essen, Germany.
Gymrek M; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA.
Anderson ND; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Shlien A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
Rotblat B; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Delattre O; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany. .; German Cancer Research Center (DKFZ), Heidelberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2019 Sep 11; Vol. 10 (1), pp. 4128. Date of Electronic Publication: 2019 Sep 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Germ-Line Mutation/*genetics
Neoplasms/*genetics
Neoplasms/*therapy
Animals ; Cell Cycle Proteins ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival ; Cyclin-Dependent Kinase 2/antagonists & inhibitors ; Cyclin-Dependent Kinase 2/metabolism ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Mice ; Microsatellite Repeats/genetics ; Neoplasm Proteins/metabolism ; Oncogene Proteins, Fusion/metabolism ; Phenotype ; Polymorphism, Genetic ; Trans-Activators ; Treatment Outcome ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
ALK mutation dynamics and clonal evolution in a neuroblastoma model exhibiting two ALK mutations.
Autorzy :
Durand S; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France.; SIREDO: Care, Innovation, and Research for Children, Adolescents, and Young Adults with Cancer, Institut Curie, Paris F-75005, France.
Pierre-Eugène C; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France.; SIREDO: Care, Innovation, and Research for Children, Adolescents, and Young Adults with Cancer, Institut Curie, Paris F-75005, France.
Mirabeau O; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France.; SIREDO: Care, Innovation, and Research for Children, Adolescents, and Young Adults with Cancer, Institut Curie, Paris F-75005, France.
Louis-Brennetot C; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France.; SIREDO: Care, Innovation, and Research for Children, Adolescents, and Young Adults with Cancer, Institut Curie, Paris F-75005, France.
Combaret V; Centre Léon Bérard, Laboratoire de Recherche Translationnelle, Lyon F-69008, France.
Colmet-Daage L; SIREDO: Care, Innovation, and Research for Children, Adolescents, and Young Adults with Cancer, Institut Curie, Paris F-75005, France.; Equipe SiRIC RTOP (Recherche Translationnelle en Oncologie Pédiatrique), Institut Curie, Paris F-75005, France.
Blanchard O; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France.; SIREDO: Care, Innovation, and Research for Children, Adolescents, and Young Adults with Cancer, Institut Curie, Paris F-75005, France.
Bellini A; SIREDO: Care, Innovation, and Research for Children, Adolescents, and Young Adults with Cancer, Institut Curie, Paris F-75005, France.; Equipe SiRIC RTOP (Recherche Translationnelle en Oncologie Pédiatrique), Institut Curie, Paris F-75005, France.
Daudigeos-Dubus E; Gustave Roussy, Vectorology and Anticancer Therapies, UMR 8203, CNRS, University Paris-Sud, Université Paris-Saclay, Villejuif F-94805, France.
Raynal V; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France.; SIREDO: Care, Innovation, and Research for Children, Adolescents, and Young Adults with Cancer, Institut Curie, Paris F-75005, France.; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris F-75005, France.
Schleiermacher G; SIREDO: Care, Innovation, and Research for Children, Adolescents, and Young Adults with Cancer, Institut Curie, Paris F-75005, France.; Equipe SiRIC RTOP (Recherche Translationnelle en Oncologie Pédiatrique), Institut Curie, Paris F-75005, France.
Baulande S; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris F-75005, France.
Delattre O; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France.; SIREDO: Care, Innovation, and Research for Children, Adolescents, and Young Adults with Cancer, Institut Curie, Paris F-75005, France.
Janoueix-Lerosey I; Institut Curie, PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France.; SIREDO: Care, Innovation, and Research for Children, Adolescents, and Young Adults with Cancer, Institut Curie, Paris F-75005, France.
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Źródło :
Oncotarget [Oncotarget] 2019 Aug 13; Vol. 10 (48), pp. 4937-4950. Date of Electronic Publication: 2019 Aug 13 (Print Publication: 2019).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
STAG Mutations in Cancer.
Autorzy :
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU, Munich, Germany.
Surdez D; INSERM U830, Équipe Labellisé LNCC 'Genetics and Biology of Pediatric Cancers', fhna PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Brunet E; Institut Imagine, INSERM UMR1163, Équipe Labellisé LNCC, Dynamics of the Genome and Immune System Lab, Paris, France.
Delattre O; INSERM U830, Équipe Labellisé LNCC 'Genetics and Biology of Pediatric Cancers', fhna PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU, Munich, Germany; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: .
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Źródło :
Trends in cancer [Trends Cancer] 2019 Aug; Vol. 5 (8), pp. 506-520. Date of Electronic Publication: 2019 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Carcinogenesis/*genetics
Cell Cycle Proteins/*genetics
Chromosomal Proteins, Non-Histone/*genetics
Neoplasms/*genetics
Nuclear Proteins/*genetics
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Line, Tumor ; Chromosomal Proteins, Non-Histone/antagonists & inhibitors ; DNA Methylation ; DNA Repair/drug effects ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Genomic Instability ; Humans ; Mutation Rate ; Neoplasms/drug therapy ; Nuclear Proteins/antagonists & inhibitors ; Promoter Regions, Genetic ; Synthetic Lethal Mutations/drug effects
Czasopismo naukowe
Tytuł :
An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma.
Autorzy :
Morabito M; Institut Curie, Orsay, France.; INSERM U1021, Centre Universitaire, Orsay, France.; CNRS UMR 3347, Centre Universitaire, Orsay, France.; University Paris Sud - Paris-Saclay, Orsay, France.; PSL Research University, Paris, France.
Larcher M; Institut Curie, Orsay, France.; INSERM U1021, Centre Universitaire, Orsay, France.; CNRS UMR 3347, Centre Universitaire, Orsay, France.; University Paris Sud - Paris-Saclay, Orsay, France.; PSL Research University, Paris, France.
Cavalli FM; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Foray C; Institut Curie, Orsay, France.; INSERM U1021, Centre Universitaire, Orsay, France.; CNRS UMR 3347, Centre Universitaire, Orsay, France.; University Paris Sud - Paris-Saclay, Orsay, France.; PSL Research University, Paris, France.
Forget A; Institut Curie, Orsay, France.; INSERM U1021, Centre Universitaire, Orsay, France.; CNRS UMR 3347, Centre Universitaire, Orsay, France.; University Paris Sud - Paris-Saclay, Orsay, France.; PSL Research University, Paris, France.
Mirabal-Ortega L; Institut Curie, Orsay, France.; INSERM U1021, Centre Universitaire, Orsay, France.; CNRS UMR 3347, Centre Universitaire, Orsay, France.; University Paris Sud - Paris-Saclay, Orsay, France.; PSL Research University, Paris, France.
Andrianteranagna M; PSL Research University, Paris, France.; Institut Curie, Paris, France.; INSERM U830, Paris, France.; Translational Research in Pediatric Oncology, Institut Curie SiRIC, Paris, France.; SIREDO Center (Care, innovation, Research in pediatric, adolescent and young adult oncology), Institut Curie, Paris, France.; INSERM, U900, Paris, France.; MINES ParisTech, CBIO-Centre for Computational Biology, Paris, France.
Druillennec S; Institut Curie, Orsay, France.; INSERM U1021, Centre Universitaire, Orsay, France.; CNRS UMR 3347, Centre Universitaire, Orsay, France.; University Paris Sud - Paris-Saclay, Orsay, France.; PSL Research University, Paris, France.
Garancher A; Institut Curie, Orsay, France.; INSERM U1021, Centre Universitaire, Orsay, France.; CNRS UMR 3347, Centre Universitaire, Orsay, France.; University Paris Sud - Paris-Saclay, Orsay, France.; PSL Research University, Paris, France.
Masliah-Planchon J; PSL Research University, Paris, France.; Institut Curie, Paris, France.; INSERM U830, Paris, France.; SIREDO Center (Care, innovation, Research in pediatric, adolescent and young adult oncology), Institut Curie, Paris, France.
Leboucher S; Institut Curie, Orsay, France.; University Paris Sud - Paris-Saclay, Orsay, France.
Debalkew A; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Raso A; Department of Patology, ASL 3 Genovese, SC Laboratorio d'Analisi, Genova, Italy.
Delattre O; PSL Research University, Paris, France.; Institut Curie, Paris, France.; INSERM U830, Paris, France.; SIREDO Center (Care, innovation, Research in pediatric, adolescent and young adult oncology), Institut Curie, Paris, France.
Puget S; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.; Département Neurochirurgie Pédiatrique, AP-HP, Hôpital Necker-Enfants Malades, Paris, France.
Doz F; Institut Curie, Paris, France.; SIREDO Center (Care, innovation, Research in pediatric, adolescent and young adult oncology), Institut Curie, Paris, France.; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Taylor MD; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.
Ayrault O; Institut Curie, Orsay, France.; INSERM U1021, Centre Universitaire, Orsay, France.; CNRS UMR 3347, Centre Universitaire, Orsay, France.; University Paris Sud - Paris-Saclay, Orsay, France.; PSL Research University, Paris, France.
Bourdeaut F; PSL Research University, Paris, France.; Institut Curie, Paris, France.; INSERM U830, Paris, France.; Translational Research in Pediatric Oncology, Institut Curie SiRIC, Paris, France.; SIREDO Center (Care, innovation, Research in pediatric, adolescent and young adult oncology), Institut Curie, Paris, France.
Eychène A; Institut Curie, Orsay, France.; INSERM U1021, Centre Universitaire, Orsay, France.; CNRS UMR 3347, Centre Universitaire, Orsay, France.; University Paris Sud - Paris-Saclay, Orsay, France.; PSL Research University, Paris, France.
Pouponnot C; Institut Curie, Orsay, France.; INSERM U1021, Centre Universitaire, Orsay, France.; CNRS UMR 3347, Centre Universitaire, Orsay, France.; University Paris Sud - Paris-Saclay, Orsay, France.; PSL Research University, Paris, France.
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Źródło :
EMBO molecular medicine [EMBO Mol Med] 2019 Aug; Vol. 11 (8), pp. e9830. Date of Electronic Publication: 2019 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autocrine Communication*
Cerebellar Neoplasms/*metabolism
Inhibin-beta Subunits/*metabolism
Medulloblastoma/*metabolism
Transforming Growth Factor beta/*metabolism
Transforming Growth Factor beta1/*metabolism
Transforming Growth Factor beta3/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Cerebellar Neoplasms/drug therapy ; Cerebellar Neoplasms/genetics ; Cerebellar Neoplasms/pathology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Inhibin-beta Subunits/genetics ; Medulloblastoma/drug therapy ; Medulloblastoma/genetics ; Medulloblastoma/pathology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice, Nude ; Phosphorylation ; Pyrazoles/pharmacology ; Quinolines/pharmacology ; Signal Transduction ; Smad2 Protein/metabolism ; Smad3 Protein/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta3/genetics ; Tumor Burden ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
ART-DeCo: easy tool for detection and characterization of cross-contamination of DNA samples in diagnostic next-generation sequencing analysis.
Autorzy :
Fiévet A; Department of Genetics, Institut Curie, 75005, Paris, France. .; Institut Curie, PSL Research University, INSERM U830, Institut de recherche, F-75005, Paris, France. .
Bernard V; Institut Curie Genomics of Excellence (ICGex) platform, Institut Curie Research Center, Paris, France.
Tenreiro H; Department of Genetics, Institut Curie, 75005, Paris, France.
Dehainault C; Department of Genetics, Institut Curie, 75005, Paris, France.
Girard E; Institut Curie, 26 rue d'Ulm, F-75005, Paris, France.; PSL Research University, F-75005, Paris, France.; Inserm, U900, F-75005, Paris, France.; Mines Paris Tech, F-77305, cedex Fontainebleau, France.
Deshaies V; Institut Curie, 26 rue d'Ulm, F-75005, Paris, France.; PSL Research University, F-75005, Paris, France.; Inserm, U900, F-75005, Paris, France.; Mines Paris Tech, F-77305, cedex Fontainebleau, France.
Hupe P; Institut Curie, 26 rue d'Ulm, F-75005, Paris, France.; PSL Research University, F-75005, Paris, France.; Inserm, U900, F-75005, Paris, France.; Mines Paris Tech, F-77305, cedex Fontainebleau, France.
Delattre O; Department of Genetics, Institut Curie, 75005, Paris, France.; Institut Curie, PSL Research University, INSERM U830, Institut de recherche, F-75005, Paris, France.
Stern MH; Department of Genetics, Institut Curie, 75005, Paris, France.; Institut Curie, PSL Research University, INSERM U830, Institut de recherche, F-75005, Paris, France.
Stoppa-Lyonnet D; Department of Genetics, Institut Curie, 75005, Paris, France.; Institut Curie, PSL Research University, INSERM U830, Institut de recherche, F-75005, Paris, France.; University Paris Descartes, Sorbonne Paris Cité, France.
Golmard L; Department of Genetics, Institut Curie, 75005, Paris, France.
Houdayer C; Department of Genetics, Institut Curie, 75005, Paris, France.; Institut Curie, PSL Research University, INSERM U830, Institut de recherche, F-75005, Paris, France.; University Paris Descartes, Sorbonne Paris Cité, France.; Department of Genetics, F76000 and Normandy Univ, UNIROUEN, Inserm U1245, Normandy Centre for Genomic and Personalized Medicine, Rouen University Hospital, Rouen, France.
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Źródło :
European journal of human genetics : EJHG [Eur J Hum Genet] 2019 May; Vol. 27 (5), pp. 792-800. Date of Electronic Publication: 2019 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Contamination*
High-Throughput Nucleotide Sequencing*
Molecular Diagnostic Techniques*
DNA/*analysis
Alleles ; Genotype ; Humans ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
SHH medulloblastoma in a young adult with a TCF4 germline pathogenic variation.
Autorzy :
Blanluet M; Unité de Génétique Somatique, Institut Curie, Paris, France.
Masliah-Planchon J; Unité de Génétique Somatique, Institut Curie, Paris, France.; Pediatric Oncology Department, SIREDO Oncology Centre (Care, Innovation, Research in Pediatric, Adolescent and Young Adults Oncology), Institut Curie, 26, rue d'Ulm, 75248, Paris Cedex 05, France.
Giurgea I; UF de Génétique Moléculaire, Hôpital Armand Trousseau, APHP, Paris, France.; Sorbonne Université, INSERM, UMR S933, Paris, France.
Bielle F; Departement de Neuropathologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.
Girard E; INSERM U900, Institut Curie, Paris, France.
Andrianteranagna M; Pediatric Oncology Department, SIREDO Oncology Centre (Care, Innovation, Research in Pediatric, Adolescent and Young Adults Oncology), Institut Curie, 26, rue d'Ulm, 75248, Paris Cedex 05, France.
Clemenceau S; Neurochirurgie, GH Pitie-Salpêtrière-Charles Foix, APHP, Paris, France.
Bourneix C; Unité de Génétique Somatique, Institut Curie, Paris, France.
Burglen L; Centre de Référence Maladies Rares 'Malformations et Maladies Congénitales du Cervelet', et Département de Génétique, Hôpital Armand Trousseau, GHUEP, APHP, Paris, France.
Doummar D; Département de Neuropédiatrie, Hôpital Armand Trousseau, APHP, Paris, France.
Rapinat A; Translational Research Department, Genomics Platform, Institut Curie, PSL Research University, Paris, 75248, France.
Oumoussa BM; Sorbonne Université, Inserm, UMS Omique, Plateforme Post-Génomique de la Pitié-Salpêtrière, P3S, 75013, Paris, France.
Ayrault O; Université Paris Sud, Université Paris-Saclay, CNRS, UMR 3347, INSERM U1021, Orsay, France.; Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.
Pouponnot C; Université Paris Sud, Université Paris-Saclay, CNRS, UMR 3347, INSERM U1021, Orsay, France.; Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.
Gentien D; Translational Research Department, Genomics Platform, Institut Curie, PSL Research University, Paris, 75248, France.
Pierron G; Unité de Génétique Somatique, Institut Curie, Paris, France.; Pediatric Oncology Department, SIREDO Oncology Centre (Care, Innovation, Research in Pediatric, Adolescent and Young Adults Oncology), Institut Curie, 26, rue d'Ulm, 75248, Paris Cedex 05, France.
Delattre O; Unité de Génétique Somatique, Institut Curie, Paris, France.; Pediatric Oncology Department, SIREDO Oncology Centre (Care, Innovation, Research in Pediatric, Adolescent and Young Adults Oncology), Institut Curie, 26, rue d'Ulm, 75248, Paris Cedex 05, France.; Inserm U830, PSL Université, Institut Curie, Paris, France.
Doz F; Pediatric Oncology Department, SIREDO Oncology Centre (Care, Innovation, Research in Pediatric, Adolescent and Young Adults Oncology), Institut Curie, 26, rue d'Ulm, 75248, Paris Cedex 05, France.; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Bourdeaut F; Pediatric Oncology Department, SIREDO Oncology Centre (Care, Innovation, Research in Pediatric, Adolescent and Young Adults Oncology), Institut Curie, 26, rue d'Ulm, 75248, Paris Cedex 05, France. .; Inserm U830, PSL Université, Institut Curie, Paris, France. .
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Źródło :
Acta neuropathologica [Acta Neuropathol] 2019 Apr; Vol. 137 (4), pp. 675-678. Date of Electronic Publication: 2019 Mar 08.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Brain Stem Neoplasms/*genetics
Hyperventilation/*genetics
Intellectual Disability/*genetics
Medulloblastoma/*genetics
Adult ; Brain Stem Neoplasms/pathology ; Facies ; Female ; Humans ; Hyperventilation/pathology ; Intellectual Disability/pathology ; Medulloblastoma/pathology
SCR Disease Name :
Pitt-Hopkins syndrome
Raport
Tytuł :
Circulating tumor DNA analysis enables molecular characterization of pediatric renal tumors at diagnosis.
Autorzy :
Jiménez I; SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Research Center, Institut Curie, Paris, France.; SiRIC RTOP « Recherche Translationelle en Oncologie Pédiatrique », Institut Curie, Paris, France.; PSL Research University, Paris, France.
Chicard M; SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Research Center, Institut Curie, Paris, France.; SiRIC RTOP « Recherche Translationelle en Oncologie Pédiatrique », Institut Curie, Paris, France.; PSL Research University, Paris, France.
Colmet-Daage L; SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Research Center, Institut Curie, Paris, France.; SiRIC RTOP « Recherche Translationelle en Oncologie Pédiatrique », Institut Curie, Paris, France.; PSL Research University, Paris, France.
Clément N; SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), Institut Curie, Paris, France.; SiRIC RTOP « Recherche Translationelle en Oncologie Pédiatrique », Institut Curie, Paris, France.; PSL Research University, Paris, France.
Danzon A; SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Research Center, Institut Curie, Paris, France.; SiRIC RTOP « Recherche Translationelle en Oncologie Pédiatrique », Institut Curie, Paris, France.; PSL Research University, Paris, France.
Lapouble E; Somatic Genetics Unit, Institut Curie, Paris, France.
Pierron G; Somatic Genetics Unit, Institut Curie, Paris, France.
Bohec M; Research Center, Institut Curie, Institut Curie Genomics of Excellence (ICGex) Platform, Paris, France.
Baulande S; Research Center, Institut Curie, Institut Curie Genomics of Excellence (ICGex) Platform, Paris, France.
Berrebi D; Service de Pathologie, Hôpital Robert Debré, APHP, Paris, France.
Fréneaux P; PSL Research University, Paris, France.; Service de Pathologie, Hospital Group, Institut Curie, Paris, France.
Coulomb A; Service de Pathologie, Hôpital Armand Trousseau, APHP, Paris, France.; Université Pierre et Marie Curie, Paris, France.
Galmiche-Rolland L; Service de Pathologie, Hôpital Necker, APHP, Paris, France.
Sarnacki S; Département de Chirurgie Pédiatrique, Hôpital Necker, APHP, Paris, France.; Université Paris Descartes, Paris, France.
Audry G; Université Pierre et Marie Curie, Paris, France.; Département de Chirurgie Pédiatrique, Hôpital Armand Trousseau, APHP, Paris, France.
Philippe-Chomette P; Département de Chirurgie Pédiatrique, Hôpital Robert Debré, APHP, Paris, France.
Brisse HJ; PSL Research University, Paris, France.; Département d'Imagerie, Hospital Group, Institut Curie, Paris, France.
Doz F; SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), Institut Curie, Paris, France.; PSL Research University, Paris, France.; Université Paris Descartes, Paris, France.
Michon J; SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), Institut Curie, Paris, France.; PSL Research University, Paris, France.
Delattre O; SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Research Center, Institut Curie, Paris, France.; PSL Research University, Paris, France.
Schleiermacher G; SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), Institut Curie, Paris, France.; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Research Center, Institut Curie, Paris, France.; SiRIC RTOP « Recherche Translationelle en Oncologie Pédiatrique », Institut Curie, Paris, France.; PSL Research University, Paris, France.
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Źródło :
International journal of cancer [Int J Cancer] 2019 Jan 01; Vol. 144 (1), pp. 68-79. Date of Electronic Publication: 2018 Oct 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers, Tumor/*genetics
Circulating Tumor DNA/*genetics
Kidney Neoplasms/*genetics
Wilms Tumor/*genetics
Biomarkers, Tumor/blood ; Child ; Child, Preschool ; Circulating Tumor DNA/blood ; DNA Copy Number Variations ; Female ; Humans ; Infant ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/therapy ; Male ; Neoadjuvant Therapy ; Nephrectomy ; Retrospective Studies ; Sensitivity and Specificity ; Whole Genome Sequencing/methods ; Wilms Tumor/diagnosis ; Wilms Tumor/therapy
Czasopismo naukowe
Tytuł :
Medullary Breast Carcinoma, a Triple-Negative Breast Cancer Associated with BCLG Overexpression.
Autorzy :
Romero P; Department of Pathology, Institut Curie, PSL Research University, Paris, France. Electronic address: .
Benhamo V; INSERM U934, Institut Curie, PSL Research University, Paris, France; Department of Translational Research, Institut Curie, PSL Research University, Paris, France.
Deniziaut G; Department of Pathology, Institut Curie, PSL Research University, Paris, France.
Fuhrmann L; Department of Pathology, Institut Curie, PSL Research University, Paris, France; INSERM U934, Institut Curie, PSL Research University, Paris, France.
Berger F; Unit of Biometry, INSERM U900, Institut Curie, PSL Research University, Paris, France.
Manié E; INSERM U934, Institut Curie, PSL Research University, Paris, France.
Bhalshankar J; INSERM U934, Institut Curie, PSL Research University, Paris, France.
Vacher S; Pharmacogenomics Unit, Department of Genetics, Institut Curie, PSL Research University, Paris, France.
Laurent C; Department of Translational Research, Institut Curie, PSL Research University, Paris, France.
Marangoni E; Department of Translational Research, Institut Curie, PSL Research University, Paris, France.
Gruel N; INSERM U934, Institut Curie, PSL Research University, Paris, France; Department of Translational Research, Institut Curie, PSL Research University, Paris, France.
MacGrogan G; Department of Biopathology, Institut Bergonié, Bordeaux, France.
Rouzier R; Department of Surgery, Institut Curie, PSL Research University, Paris, France.
Delattre O; INSERM U934, Institut Curie, PSL Research University, Paris, France.
Popova T; INSERM U934, Institut Curie, PSL Research University, Paris, France.
Reyal F; Department of Translational Research, Institut Curie, PSL Research University, Paris, France; Department of Surgery, Institut Curie, PSL Research University, Paris, France.
Stern MH; Department of Pathology, Institut Curie, PSL Research University, Paris, France; INSERM U934, Institut Curie, PSL Research University, Paris, France.
Stoppa-Lyonnet D; Department of Pathology, Institut Curie, PSL Research University, Paris, France; INSERM U934, Institut Curie, PSL Research University, Paris, France; Sorbonne Paris Cité, University Paris Descartes, Paris, France.
Marchiò C; Department of Pathology, Institut Curie, PSL Research University, Paris, France; Institute of Pathology at the Department of Medical Sciences, University of Turin, Turin, Italy.
Bièche I; Pharmacogenomics Unit, Department of Genetics, Institut Curie, PSL Research University, Paris, France; EA 7331, University Paris Descartes, Paris, France.
Vincent-Salomon A; Department of Pathology, Institut Curie, PSL Research University, Paris, France; INSERM U934, Institut Curie, PSL Research University, Paris, France.
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Źródło :
The American journal of pathology [Am J Pathol] 2018 Oct; Vol. 188 (10), pp. 2378-2391. Date of Electronic Publication: 2018 Aug 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Medullary/*genetics
Proto-Oncogene Proteins c-bcl-2/*genetics
Triple Negative Breast Neoplasms/*genetics
BRCA2 Protein/genetics ; DNA, Neoplasm/metabolism ; Female ; Gene Expression Profiling ; Genes, Neoplasm/genetics ; Humans ; Loss of Heterozygosity/genetics ; RNA, Neoplasm/metabolism ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe

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