Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Delattre, O."" wg kryterium: Autor


Tytuł :
Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis.
Autorzy :
El-Naggar AM; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.; Department of Pathology, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt.
Somasekharan SP; Vancouver Prostate Centre, Vancouver, BC, Canada.
Wang Y; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Cheng H; Vancouver Prostate Centre, Vancouver, BC, Canada.
Negri GL; Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Pan M; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Wang XQ; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Delaidelli A; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Rafn B; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Cran J; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Zhang F; Vancouver Prostate Centre, Vancouver, BC, Canada.
Zhang H; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Colborne S; Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Gleave M; Vancouver Prostate Centre, Vancouver, BC, Canada.
Mandinova A; Brigham and Women's Hospital, Harvard University, Boston, MA, USA.
Kedersha N; Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Hughes CS; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Surdez D; Centre de recherche de l'Institut Curie, Paris, France.
Delattre O; Centre de recherche de l'Institut Curie, Paris, France.
Wang Y; Vancouver Prostate Centre, Vancouver, BC, Canada.
Huntsman DG; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Morin GB; Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Sorensen PH; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, BC, Canada.
Pokaż więcej
Źródło :
EMBO reports 2019 Dec 05; Vol. 20 (12), pp. e48375. Date of Electronic Publication: 2019 Oct 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Benzamides/*therapeutic use
Bone Neoplasms/*drug therapy
Histone Deacetylase Inhibitors/*therapeutic use
Pyridines/*therapeutic use
Sarcoma, Ewing/*drug therapy
Transcription Factors/*metabolism
Acetylation ; Animals ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cells, Cultured ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mice ; NF-E2-Related Factor 2/metabolism ; Neoplasm Metastasis ; Oxidative Stress ; Sarcoma, Ewing/metabolism ; Sarcoma, Ewing/pathology
Czasopismo naukowe
Tytuł :
Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response.
Autorzy :
Pishas KI; Cancer Therapeutics Laboratory, Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia.; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Drenberg CD; Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio.; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
Taslim C; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Theisen ER; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Johnson KM; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Saund RS; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Pop IL; Huntsman Cancer Institute, School of Medicine, University of Utah, Salt Lake City, Utah.
Crompton BD; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.
Lawlor ER; Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan.; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
Tirode F; Univ Lyon, Universite Claude Bernard Lyon, Centre Leon Berard, Cancer Research Center of Lyon, Lyon, France.
Mora J; Department of Pediatric Hemato-Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.
Delattre O; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.
Beckerle MC; Huntsman Cancer Institute, School of Medicine, University of Utah, Salt Lake City, Utah.
Callen DF; Cancer Therapeutics Laboratory, Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Sharma S; TGen Clinical Sciences, Applied Cancer Research and Drug Discovery, Phoenix, Arizona.
Lessnick SL; Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio. .; Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Ohio State University, Columbus, Ohio.
Pokaż więcej
Źródło :
Molecular cancer therapeutics 2018 Sep; Vol. 17 (9), pp. 1902-1916. Date of Electronic Publication: 2018 Jul 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Neoplasms/*drug therapy
Endoplasmic Reticulum Stress/*drug effects
Enzyme Inhibitors/*pharmacology
Histone Demethylases/*antagonists & inhibitors
Sarcoma, Ewing/*drug therapy
Adolescent ; Apoptosis/drug effects ; Apoptosis/genetics ; Bone Neoplasms/enzymology ; Bone Neoplasms/genetics ; Cell Line, Tumor ; Child ; Endoplasmic Reticulum Stress/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Humans ; RNA Interference ; Sarcoma, Ewing/enzymology ; Sarcoma, Ewing/genetics ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Small Molecule Libraries/pharmacology
Czasopismo naukowe
Tytuł :
Does ATRX germline variation predispose to osteosarcoma? Three additional cases of osteosarcoma in two ATR-X syndrome patients.
Autorzy :
Masliah-Planchon J; Unité de Génétique Somatique, Institut Curie, Paris, France.; Unité INSERMU830, Institut Curie, Paris, France.
Lévy D; Département d'Oncologie Pédiatrique et d'Adolescents Jeunes Adultes, Institut Curie, Paris, France.
Héron D; Département de Génétique, Hôpital de la Pitié-Salpétrière - APHP, Paris, France.
Giuliano F; Département de Génétique Médicale, CHU Nice, Hôpital l'Archet 2, Nice, France.
Badens C; Département de Génétique Médicale, Hôpital de la Timone, Marseille, France.
Fréneaux P; Département de Pathologie, Institut Curie, Paris, France.
Galmiche L; Département de Pathologie, Hôpital Necker-Enfants Malades - APHP, Paris, France.
Guinebretierre JM; Département de Pathologie, Institut Curie, Paris, France.
Cellier C; Département de Radiologie, Institut Curie, Paris, France.
Waterfall JJ; Unité INSERMU830, Institut Curie, Paris, France.; Département de Recherche Translationnelle, Institut Curie, Paris, France.
Aït-Raïs K; Unité de Génétique Somatique, Institut Curie, Paris, France.
Pierron G; Unité de Génétique Somatique, Institut Curie, Paris, France.
Glorion C; Service d'Orthopédie Pédiatrique, Hôpital Necker-Enfants malades - APHP, Paris, France.
Desguerre I; Neuropédiatrie, Hôpital Necker-Enfants malades - APHP, Paris, France.
Soler C; Service d'Onco-Hématologie Pédiatrique, CHU Nice, Hôpital l'Archet 2, Nice, France.
Deville A; Service d'Onco-Hématologie Pédiatrique, CHU Nice, Hôpital l'Archet 2, Nice, France.
Delattre O; Unité de Génétique Somatique, Institut Curie, Paris, France.; Unité INSERMU830, Institut Curie, Paris, France.
Michon J; Département d'Oncologie Pédiatrique et d'Adolescents Jeunes Adultes, Institut Curie, Paris, France.
Bourdeaut F; Unité INSERMU830, Institut Curie, Paris, France. .; Département d'Oncologie Pédiatrique et d'Adolescents Jeunes Adultes, Institut Curie, Paris, France. .
Pokaż więcej
Źródło :
European journal of human genetics : EJHG [Eur J Hum Genet] 2018 Aug; Vol. 26 (8), pp. 1217-1221. Date of Electronic Publication: 2018 Apr 30.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Germ-Line Mutation*
Bone Neoplasms/*genetics
Mental Retardation, X-Linked/*genetics
Osteosarcoma/*genetics
alpha-Thalassemia/*genetics
Bone Neoplasms/epidemiology ; Bone Neoplasms/pathology ; Child ; Female ; Humans ; Male ; Mental Retardation, X-Linked/complications ; Mental Retardation, X-Linked/pathology ; Osteosarcoma/epidemiology ; Osteosarcoma/pathology ; Pedigree ; X-linked Nuclear Protein/genetics ; alpha-Thalassemia/complications ; alpha-Thalassemia/pathology
SCR Disease Name :
ATR-X syndrome
Czasopismo naukowe
Tytuł :
Transcriptomic definition of molecular subgroups of small round cell sarcomas.
Autorzy :
Watson S; INSERM U830, Laboratory of Genetics and Biology of Cancer, Paris, France.; Institut Curie, Paris Sciences et Lettres, Paris, France.
Perrin V; INSERM U830, Laboratory of Genetics and Biology of Cancer, Paris, France.; Institut Curie, Paris Sciences et Lettres, Paris, France.
Guillemot D; Institut Curie, Unité de Génétique Somatique, Paris, France.
Reynaud S; Institut Curie, Unité de Génétique Somatique, Paris, France.
Coindre JM; Institut Bergonié, Department of Pathology, Bordeaux, France.; Université Bordeaux 2, Bordeaux, France.
Karanian M; Centre Leon Bérard, Department of Pathology, Lyon, France.
Guinebretière JM; Service de Pathologie, Hôpital René-Huguenin, Institut Curie, Saint-Cloud, France.
Freneaux P; Département de Biologie des Tumeurs, Institut Curie, Service d'Anatomie Pathologique, Paris, France.
Le Loarer F; Institut Bergonié, Department of Pathology, Bordeaux, France.; Université Bordeaux 2, Bordeaux, France.
Bouvet M; Institut Curie, Unité de Génétique Somatique, Paris, France.
Galmiche-Rolland L; Service d'Anatomie Pathologique, Hôpital Necker Enfants Malades, Paris, France.; Université Paris Descartes, Paris, France.
Larousserie F; Service d'Anatomie Pathologique, Hôpital Cochin, Paris, France.
Longchampt E; Service d'Anatomie et de Cytologie Pathologiques, Hôpital Foch, Suresnes, France.
Ranchere-Vince D; Centre Leon Bérard, Department of Pathology, Lyon, France.
Pierron G; Institut Curie, Unité de Génétique Somatique, Paris, France.
Delattre O; INSERM U830, Laboratory of Genetics and Biology of Cancer, Paris, France.; Institut Curie, Paris Sciences et Lettres, Paris, France.; Institut Curie, Unité de Génétique Somatique, Paris, France.; Ligue Contre le Cancer, Equipe Labellisée.
Tirode F; INSERM U830, Laboratory of Genetics and Biology of Cancer, Paris, France.; Institut Curie, Paris Sciences et Lettres, Paris, France.; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Cancer Research Center of Lyon, Centre Léon Bérard, Lyon, France.
Pokaż więcej
Źródło :
The Journal of pathology [J Pathol] 2018 May; Vol. 245 (1), pp. 29-40. Date of Electronic Publication: 2018 Mar 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Neoplasms/*genetics
Oncogene Proteins, Fusion/*genetics
Sarcoma, Small Cell/*genetics
Transcriptome/*genetics
Biomarkers, Tumor/genetics ; DNA-Binding Proteins/genetics ; Gene Fusion/genetics ; Humans ; Muscle Proteins/genetics ; Repressor Proteins/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.
Autorzy :
Sheffield NC; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Pierron G; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.
Klughammer J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Datlinger P; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schönegger A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schuster M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Hadler J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Surdez D; Institut Curie, PSL Research University, INSERM, U830, Paris, France.
Guillemot D; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.
Lapouble E; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.
Freneaux P; Institut Curie, PSL Research University, Service de Pathologie, Pole de Medecine Diagnostique et Theranostique, Paris, France.
Champigneulle J; Service d'Anatomie et de Cytologie Pathologiques, Hopitaux de Brabois, Hopital d'Adultes, Nancy, France.
Bouvier R; Centre de Pathologie du Pôle Est, Hopitaux de Lyon, Lyon, France.
Walder D; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Ambros IM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Hutter C; St. Anna Children's Hospital, St. Anna Kinderspital, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Sorz E; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Amaral AT; Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital/CSIC/University of Sevilla, Seville, Spain.
de Álava E; Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital/CSIC/University of Sevilla, Seville, Spain.
Schallmoser K; Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.; Department of Blood Group Serology and Transfusion Medicine, Paracelsus Medical University, Salzburg, Austria.
Strunk D; Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.; Institute for Experimental and Clinical Cell Therapy, Paracelsus Medical University, Salzburg, Austria.
Rinner B; Division of Biomedical Research, Medical University of Graz, Graz, Austria.
Liegl-Atzwanger B; Institute of Pathology, Medical University of Graz, Graz, Austria.
Huppertz B; Organizational Unit of Research Infrastructure, Biobank Graz, Medical University of Graz, Graz, Austria.
Leithner A; Department of Orthopedic Surgery, Medical University of Graz, Graz, Austria.
de Pinieux G; Service d'Anatomie et de Cytologie Pathologiques, Hôpital Universitaire Trousseau, Tours, France.
Terrier P; Gustave Roussy, Département de Pathologie, Villejuif, France.
Laurence V; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.; Institut Curie, PSL Research University, Departement d'Oncologie Pédiatrique Adolescent Jeunes Adultes, Paris, France.
Michon J; Institut Curie, PSL Research University, Departement d'Oncologie Pédiatrique Adolescent Jeunes Adultes, Paris, France.
Ladenstein R; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; St. Anna Children's Hospital, St. Anna Kinderspital, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Holter W; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; St. Anna Children's Hospital, St. Anna Kinderspital, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Windhager R; Department of Orthopedics, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
Dirksen U; University Hospital Münster, Department of Pediatrics and Pediatric Hematology and Oncology, Münster, Germany.
Ambros PF; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Delattre O; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.; Institut Curie, PSL Research University, INSERM, U830, Paris, France.
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.; Max Planck Institute for Informatics, Saarland Informatics Campus, Saarbrücken, Germany.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Tomazou EM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Pokaż więcej
Źródło :
Nature medicine [Nat Med] 2017 Mar; Vol. 23 (3), pp. 386-395. Date of Electronic Publication: 2017 Jan 30.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Bone Neoplasms/*genetics
DNA Methylation/*genetics
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
Adolescent ; Adult ; Cell Line, Tumor ; Child ; Child, Preschool ; Epigenesis, Genetic ; Female ; Genetic Heterogeneity ; Humans ; Male ; Middle Aged ; Promoter Regions, Genetic/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
High-throughput RNAi screen in Ewing sarcoma cells identifies leucine rich repeats and WD repeat domain containing 1 (LRWD1) as a regulator of EWS-FLI1 driven cell viability.
Autorzy :
He T; VTT Technical Research Centre of Finland, Turku, Finland.
Surdez D; Institut Curie, Unité de génétique somatique, Paris, France; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France; INSERM U830, Institut Curie Research Center, Paris, France.
Rantala JK; Misvik Biology, Turku, Finland.
Haapa-Paananen S; VTT Technical Research Centre of Finland, Turku, Finland.
Ban J; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Kauer M; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Tomazou E; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Fey V; VTT Technical Research Centre of Finland, Turku, Finland.
Alonso J; Unidad de Tumores Sólidos Infantiles, Área de Genética Humana, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain.
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria; Department of Pediatrics, Medical University, Vienna, Austria.
Delattre O; Institut Curie, Unité de génétique somatique, Paris, France; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France; INSERM U830, Institut Curie Research Center, Paris, France; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.
Iljin K; VTT Technical Research Centre of Finland, Turku, Finland. Electronic address: .
Pokaż więcej
Źródło :
Gene [Gene] 2017 Jan 05; Vol. 596, pp. 137-146. Date of Electronic Publication: 2016 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*genetics
Microtubule Proteins/*genetics
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
Bone Neoplasms/mortality ; Bone Neoplasms/pathology ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Survival/genetics ; Doxycycline/pharmacology ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; High-Throughput Nucleotide Sequencing ; Humans ; Kaplan-Meier Estimate ; Male ; Microtubule Proteins/metabolism ; Oncogene Proteins, Fusion/metabolism ; Proto-Oncogene Protein c-fli-1/metabolism ; RNA Interference ; RNA-Binding Protein EWS/metabolism ; Sarcoma, Ewing/mortality ; Sarcoma, Ewing/pathology ; WD40 Repeats
Czasopismo naukowe
Tytuł :
[Cooperation between a somatic mutation and a genetic susceptibility variant in Ewing sarcoma].
Autorzy :
Grünewald TG; Laboratory for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Thalkirchnerstrasse 36, 80337 Munich, Allemagne - Institut Curie, PSL Research University, unité de Génétique et Biologie des Cancers, 26, rue d'Ulm, 75248 Cedex 05 Paris, France - Inserm U830, Institut Curie, Centre de recherches, 26, rue d'Ulm, 75248 Paris, France.
Gilardi-Hebenstreit P; École normale supérieure, PSL Research University, Inserm U1024, CNRS UMR8197, Institut de biologie de l'ENS (IBENS), 46, rue d'Ulm, 75005 Paris, France.
Charnay P; École normale supérieure, PSL Research University, Inserm U1024, CNRS UMR8197, Institut de biologie de l'ENS (IBENS), 46, rue d'Ulm, 75005 Paris, France.
Delattre O; Institut Curie, PSL Research University, unité de Génétique et Biologie des Cancers, 26, rue d'Ulm, 75248 Cedex 05 Paris, France - Inserm U830, Institut Curie, Centre de recherches, 26, rue d'Ulm, 75248 Paris, France - Unité Génétique Somatique (UGS), Institut Curie, Centre hospitalier, 26, rue d'Ulm, 75248 Paris, France.
Pokaż więcej
Transliterated Title :
Coopération entre mutation somatique et variant génétique de susceptibilité dans le sarcome d'Ewing.
Źródło :
Medecine sciences : M/S [Med Sci (Paris)] 2016 Apr; Vol. 32 (4), pp. 323-6. Date of Electronic Publication: 2016 May 02.
Typ publikacji :
Wiadomości
MeSH Terms :
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Bone Neoplasms/*genetics
Mutation/*physiology
Sarcoma, Ewing/*genetics
Bone Neoplasms/pathology ; Early Growth Response Protein 2/genetics ; Epistasis, Genetic ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Oncogene Proteins, Fusion/physiology ; Sarcoma, Ewing/pathology
Periodyk
Tytuł :
The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease.
Autorzy :
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University Vienna, Vienna, Austria.
Amatruda J; Departments of Pediatrics, Molecular Biology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Brunet E; Museum National d'Histoire Naturelle, INSERM U1154, CNRS 7196, Paris, France.
Burdach S; Children's Cancer Research Center and Department of Pediatrics, Klinikum rechts der Isar, Technical University and Comprehensive Cancer Center Munich (CCCM), Munich, Germany.
Cidre-Aranaz F; Unidad de Tumores Sólidos Infantiles, Área de Genética Humana, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain.
de Alava E; Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital /CSIC/University de Sevilla, Department of Pathology, Seville, Spain.
Dirksen U; University Children´s Hospital Muenster, Pediatric Hematology and Oncology, Muenster, Germany.
van der Ent W; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; Institute of Biology, Leiden University, Leiden, The Netherlands.
Grohar P; Van Andel Institute, Center for Cancer and Cell Biology and Helen DeVos Children's Hospital, Grand Rapids, MI, USA.
Grünewald TG; Laboratory for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Helman L; Center for Cancer Rearch, NCI, NIH, Bethesda, MA, USA.
Houghton P; Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX, USA.
Iljin K; VTT Technical Research Centre of Finland Ltd, Espoo, Finland.
Korsching E; Institute of Bioinformatics, Faculty of Medicine, University of Muenster, Muenster, Germany.
Ladanyi M; Department of Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Lawlor E; Department of Pediatrics and Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Lessnick S; Center for Childhood Cancer and Blood Disorders, Nationwide Children's Hospital, and the Division of Pediatric Hematology/Oncology/BMT, The Ohio State University, Columbus, OH, USA.
Ludwig J; Department of Sarcoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Meltzer P; Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Metzler M; Pediatric Oncology and Hematology, University Hospital Erlangen, Erlangen, Germany.
Mora J; Department of Pediatric Oncology, Sant Joan de Déu Hospital, Barcelona, Spain.
Moriggl R; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine and Medical University, Vienna, Austria.
Nakamura T; Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Papamarkou T; University of Glasgow, School of Mathematics and Statistics, Glasgow, UK.
Radic Sarikas B; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Rédini F; INSERM UMR957, Université de Nantes, Nantes, France.
Richter GH; Children's Cancer Research Center and Department of Pediatrics, Klinikum rechts der Isar, Technical University and Comprehensive Cancer Center Munich (CCCM), Munich, Germany.
Rossig C; University Children´s Hospital Muenster, Pediatric Hematology and Oncology, Muenster, Germany.
Schadler K; Department of Pediatrics Research, MD Anderson Cancer Center, Houston, TX, USA.
Schäfer BW; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.
Scotlandi K; CRS Development of Biomolecular Therapies, Experimental Oncology Lab, Rizzoli Institute, Bologna, Italy.
Sheffield NC; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Shelat A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis,TN, USA.
Snaar-Jagalska E; Institute of Biology, Leiden University, Leiden, The Netherlands.
Sorensen P; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.
Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA.
Stewart E; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Sweet-Cordero A; Division of Hematology and Oncology, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Szuhai K; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.
Tirado OM; Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Tirode F; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.
Toretsky J; Department of Oncology, Georgetown University School of Medicine, Washington, DC, USA.
Tsafou K; Department of Oncology, Georgetown University School of Medicine, Washington, DC, USA.
Üren A; Department of Oncology, Georgetown University School of Medicine, Washington, DC, USA.
Zinovyev A; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.; INSERM, U900, Paris, France.; Ecole des Mines ParisTech, Fontainbleau, France.
Delattre O; INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.
Pokaż więcej
Źródło :
Oncotarget [Oncotarget] 2016 Feb 23; Vol. 7 (8), pp. 8613-24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Bone Neoplasms/*pathology
Oncogene Proteins, Fusion/*metabolism
Proto-Oncogene Protein c-fli-1/*metabolism
RNA-Binding Protein EWS/*metabolism
Sarcoma, Ewing/*pathology
Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Sarcoma, Ewing/genetics ; Sarcoma, Ewing/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Ewing Sarcoma: Current Management and Future Approaches Through Collaboration.
Autorzy :
Gaspar N; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Hawkins DS; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Dirksen U; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Lewis IJ; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Ferrari S; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Le Deley MC; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Kovar H; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Grimer R; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Whelan J; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Claude L; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Delattre O; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Paulussen M; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Picci P; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Sundby Hall K; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
van den Berg H; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Ladenstein R; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Michon J; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Hjorth L; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Judson I; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Luksch R; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Bernstein ML; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Marec-Bérard P; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Brennan B; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Craft AW; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Womer RB; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Juergens H; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Oberlin O; Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O
Pokaż więcej
Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2015 Sep 20; Vol. 33 (27), pp. 3036-46. Date of Electronic Publication: 2015 Aug 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Interdisciplinary Communication*
International Cooperation*
Bone Neoplasms/*therapy
Medical Oncology/*trends
Pediatrics/*trends
Sarcoma, Ewing/*therapy
Adolescent ; Age of Onset ; Bone Neoplasms/diagnosis ; Bone Neoplasms/mortality ; Child ; Cooperative Behavior ; Diffusion of Innovation ; Forecasting ; Humans ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/mortality ; Survivors ; Time Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.
Autorzy :
Grünewald TG; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Bernard V; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.
Gilardi-Hebenstreit P; École Normale Supérieure (ENS), Institut de Biologie de l'ENS (IBENS), INSERM U1024, CNRS UMR8197, Paris, France.
Raynal V; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.
Surdez D; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Aynaud MM; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Mirabeau O; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Cidre-Aranaz F; Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain.
Tirode F; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Zaidi S; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Perot G; INSERM U916 Biology of Sarcomas, Institut Bergonié, Bordeaux, France.
Jonker AH; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Lucchesi C; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.
Le Deley MC; Département d'Epidémiologie et de Biostatistiques, Institut Gustave Roussy, Villejuif, France.
Oberlin O; Département de Pédiatrie, Institut Gustave Roussy, Villejuif, France.
Marec-Bérard P; Institute for Pediatric Hematology and Oncology, Leon-Bérard Cancer Center, University of Lyon, Lyon, France.
Véron AS; INSERM U1052, Léon-Bérard Cancer Centre, Cancer Research Center of Lyon, Lyon, France.
Reynaud S; Unité Génétique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
Lapouble E; Unité Génétique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
Boeva V; INSERM U900, Bioinformatics, Biostatistics, Epidemiology and Computational Systems Biology of Cancer, Institut Curie Research Center, Paris, France.; Mines ParisTech, Fontainebleau, France.
Rio Frio T; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.
Alonso J; Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain.
Bhatia S; Institute for Cancer Outcomes and Survivorship, School of Medicine, University of Alabama, Birmingham, Alabama, USA.
Pierron G; Unité Génétique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
Cancel-Tassin G; Centre de Recherche sur les Pathologies Prostatiques (CeRePP)-Laboratory for Urology, Research Team 2, UPMC, Hôpital Tenon, Paris, France.
Cussenot O; Centre de Recherche sur les Pathologies Prostatiques (CeRePP)-Laboratory for Urology, Research Team 2, UPMC, Hôpital Tenon, Paris, France.
Cox DG; INSERM U1052, Léon-Bérard Cancer Centre, Cancer Research Center of Lyon, Lyon, France.
Morton LM; Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Bethesda, Maryland, USA.
Machiela MJ; Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Bethesda, Maryland, USA.
Chanock SJ; Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Bethesda, Maryland, USA.
Charnay P; École Normale Supérieure (ENS), Institut de Biologie de l'ENS (IBENS), INSERM U1024, CNRS UMR8197, Paris, France.
Delattre O; Genetics and Biology of Cancers Unit, Institut Curie, PSL Research University, Paris, France.; INSERM U830, Institut Curie Research Center, Paris, France.; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.; Unité Génétique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
Pokaż więcej
Źródło :
Nature genetics [Nat Genet] 2015 Sep; Vol. 47 (9), pp. 1073-8. Date of Electronic Publication: 2015 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Neoplasms/*genetics
Early Growth Response Protein 2/*genetics
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
Animals ; Base Sequence ; Bone Neoplasms/pathology ; Carotenoids/genetics ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression ; Gene Expression Regulation, Neoplastic ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Mice, SCID ; Microsatellite Repeats ; Molecular Sequence Data ; Neoplasm Transplantation ; Oxygenases/genetics ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Sarcoma, Ewing/pathology ; Tumor Burden
Czasopismo naukowe
Tytuł :
Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe.
Autorzy :
Bölling T; Department Osnabrueck, Center for Radiotherapy Rheine-Osnabrueck, Osnabrueck, Germany.
Braun-Munzinger G; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Burdach S; Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Calaminus G; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Craft A; Royal Victoria Infirmary, Newcastle, United Kingdom.
Delattre O; Inserm U830, Laboratory of Genetics and Biology of Cancers, Institut Curie, Paris, France.
Deley MC; Université Paris-Sud, Le Kremlin-Bicêtre, and Gustave Roussy Institute, Villejuif, France.
Dirksen U; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Dockhorn-Dworniczak B; Zentrum für Pathologie Kempten-Allgäu, Kempten, Germany.
Dunst J; Department of Radiation Oncology, University of Luebeck and University Medical Center Schleswig-Holstein, Campus Luebeck, Germany.
Engel S; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Faldum A; Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany.
Fröhlich B; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Gadner H; St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
Göbel U; Clinic of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, Duesseldorf, Germany.
Gosheger G; Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
Hardes J; Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
Hawkins DS; Seattle Children's Hospital and Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA.
Hjorth L; Skåne University Hospital, Lund University, Lund, Sweden.
Hoffmann C; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Kovar H; St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
Kruseova J; Department of Paediatric Haematology and Oncology Charles University, 2nd School of Medicine, Prague, Czech Republic.
Ladenstein R; St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
Leuschner I; Kiel Paediatric Tumor Registry, Department of Paediatric Pathology, Christian-Albrechts-University Kiel, Kiel, Germany.
Lewis IJ; Alder Hey Children's National Health Service Foundation Trust, Liverpool, UK.
Oberlin O; Gustave Roussy Institute, Villejuif, France.
Paulussen M; Vestische Kinder-und Jugendklinik Datteln, Witten/Herdecke University, Datteln, Germany.
Potratz J; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Ranft A; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Rössig C; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Rübe C; Department of Radiotherapy and Radiation Oncology, Saarland University Medical Center, Homburg, Germany.
Sauer R; Department of Radiation Therapy, University of Erlangen, Erlangen, Germany.
Schober O; Department of Nuclear Medicine, University of Münster, Münster, Germany.
Schuck A; Department of Radiotherapy, University Hospital Muenster, Muenster, Germany.
Timmermann B; Clinic for Particle Therapy, West German Proton Therapy Center Essen, West German Cancer Center, University Hospital Essen.
Tirode F; Inserm U830, Laboratory of Genetics and Biology of Cancers, Institut Curie, Paris, France.
van den Berg H; Emma Children Hospital AMC, University of Amsterdam, Amsterdam, the Netherlands.
van Valen F; Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany.
Vieth V; Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
Willich N; Department of Radiotherapy, University Hospital Muenster, Muenster, Germany.
Winkelmann W; Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
Whelan J; NIHR University College London Hospitals Biomedical Research Centre, London, UK.
Womer RB; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Pokaż więcej
Źródło :
Klinische Padiatrie [Klin Padiatr] 2015 May; Vol. 227 (3), pp. 108-15. Date of Electronic Publication: 2015 May 18.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cooperative Behavior*
Interdisciplinary Communication*
Bone Neoplasms/*therapy
Sarcoma, Ewing/*therapy
Soft Tissue Neoplasms/*therapy
Antineoplastic Combined Chemotherapy Protocols ; Bone Neoplasms/mortality ; Child ; Clinical Trials as Topic ; Combined Modality Therapy ; Disease Progression ; Humans ; Neoadjuvant Therapy ; Osteotomy ; Radiotherapy, Adjuvant ; Sarcoma, Ewing/mortality ; Soft Tissue Neoplasms/mortality ; Survival Rate
Czasopismo naukowe
Tytuł :
Ewing-like sarcomas with BCOR-CCNB3 fusion transcript: a clinical, radiological and pathological retrospective study from the Société Française des Cancers de L'Enfant.
Autorzy :
Cohen-Gogo S; INSERM U830, Institut Curie - Research Center, 26 rue d'Ulm, Paris, Cedex 5, France.
Cellier C
Coindre JM
Mosseri V
Pierron G
Guillemet C
Italiano A
Brugières L
Orbach D
Laurence V
Delattre O
Michon J
Pokaż więcej
Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2014 Dec; Vol. 61 (12), pp. 2191-8. Date of Electronic Publication: 2014 Aug 31.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Fusion*
Bone Neoplasms/*pathology
Cyclin B/*genetics
Lung Neoplasms/*secondary
Proto-Oncogene Proteins/*genetics
Repressor Proteins/*genetics
Sarcoma, Ewing/*secondary
Adolescent ; Adult ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/genetics ; Child ; Combined Modality Therapy ; Female ; Follow-Up Studies ; France ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/genetics ; Male ; Neoplasm Staging ; Prognosis ; Radiography ; Retrospective Studies ; Sarcoma, Ewing/diagnostic imaging ; Sarcoma, Ewing/genetics ; Survival Rate ; Young Adult
Czasopismo naukowe
Tytuł :
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.
Autorzy :
Tirode F; INSERM U830, Laboratory of Genetics and Cancer Biology, Institut Curie, Paris, France. Centre de Recherche, Institut Curie, Paris, France.
Surdez D; INSERM U830, Laboratory of Genetics and Cancer Biology, Institut Curie, Paris, France. Centre de Recherche, Institut Curie, Paris, France.
Ma X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Parker M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Le Deley MC; Departement d'Epidémiologie et de Biostatistiques, Gustave Roussy, Villejuif, France.
Bahrami A; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Zhang Z; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Lapouble E; Unité de Génétique Somatique, Centre Hospitalier, Institut Curie, Paris, France.
Grossetête-Lalami S; INSERM U830, Laboratory of Genetics and Cancer Biology, Institut Curie, Paris, France. Centre de Recherche, Institut Curie, Paris, France.
Rusch M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Reynaud S; Unité de Génétique Somatique, Centre Hospitalier, Institut Curie, Paris, France.
Rio-Frio T; Centre de Recherche, Institut Curie, Paris, France.
Hedlund E; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Wu G; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Chen X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Pierron G; Unité de Génétique Somatique, Centre Hospitalier, Institut Curie, Paris, France.
Oberlin O; Departement de Pédiatrie, Gustave Roussy, Villejuif, France.
Zaidi S; INSERM U830, Laboratory of Genetics and Cancer Biology, Institut Curie, Paris, France. Centre de Recherche, Institut Curie, Paris, France.
Lemmon G; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Gupta P; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Vadodaria B; The Pediatric Cancer Genome Laboratory, St. Jude Children's Research Hospital, Memphis, Tennessee.
Easton J; The Pediatric Cancer Genome Laboratory, St. Jude Children's Research Hospital, Memphis, Tennessee.
Gut M; Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain.
Ding L; Department of Genetics, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Department of Medicine, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Mardis ER; Department of Genetics, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Department of Medicine, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Wilson RK; Department of Genetics, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Department of Medicine, The Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Shurtleff S; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Laurence V; Département d'Oncologie Medicale, Adolescents et Jeunes Adultes, Centre Hospitalier, Institut Curie, Paris, France.
Michon J; Département d'Oncologie Pediatrique, Adolescents et Jeunes Adultes, Centre Hospitalier, Institut Curie, Paris, France.
Marec-Bérard P; Institute for Paediatric Haematology and Oncology, Leon Bérard Cancer Centre, University of Lyon, Lyon, France.
Gut I; Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain.
Downing J; The Pediatric Cancer Genome Laboratory, St. Jude Children's Research Hospital, Memphis, Tennessee.
Dyer M; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee. Howard Hughes Medical Institute, Chevy Chase, Maryland.
Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee. olivier.delattre@curie.fr .
Delattre O; INSERM U830, Laboratory of Genetics and Cancer Biology, Institut Curie, Paris, France. Centre de Recherche, Institut Curie, Paris, France. olivier.delattre@curie.fr .
Pokaż więcej
Corporate Authors :
St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project and the International Cancer Genome Consortium
Źródło :
Cancer discovery [Cancer Discov] 2014 Nov; Vol. 4 (11), pp. 1342-53. Date of Electronic Publication: 2014 Sep 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Nuclear/*genetics
Bone Neoplasms/*genetics
Sarcoma, Ewing/*genetics
Tumor Suppressor Protein p53/*genetics
Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; DNA, Neoplasm/genetics ; Genomics ; Humans ; Mutation ; Prognosis ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis.
Autorzy :
Stoll G; Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 05, France, INSERM U900, Bioinformatique, biostatistique et épidémiologie d'un système complexe, Paris, France, Mines ParisTech, Fontainebleau, France, INSERM U830, Unité de Génétique et Biologie des Cancers, Paris, France and Institut Curie, Unité de génétique somatique, Paris, France.
Surdez D
Tirode F
Laud K
Barillot E
Zinovyev A
Delattre O
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2013 Oct; Vol. 41 (19), pp. 8853-71. Date of Electronic Publication: 2013 Aug 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Gene Regulatory Networks*
Apoptosis/*genetics
Bone Neoplasms/*genetics
Oncogene Proteins, Fusion/*metabolism
Proto-Oncogene Protein c-fli-1/*metabolism
RNA-Binding Protein EWS/*metabolism
Sarcoma, Ewing/*genetics
Bone Neoplasms/metabolism ; Cell Line, Tumor ; Data Mining ; Gene Expression Regulation, Neoplastic ; Humans ; Models, Genetic ; Oncogene Proteins, Fusion/antagonists & inhibitors ; Oncogene Proteins, Fusion/genetics ; Proto-Oncogene Protein c-fli-1/antagonists & inhibitors ; Proto-Oncogene Protein c-fli-1/genetics ; RNA, Small Interfering/metabolism ; RNA-Binding Protein EWS/antagonists & inhibitors ; RNA-Binding Protein EWS/genetics ; Sarcoma, Ewing/metabolism ; Signal Transduction ; Systems Biology ; Transcriptome
Czasopismo naukowe
Tytuł :
Zoledronic acid as a new adjuvant therapeutic strategy for Ewing's sarcoma patients.
Autorzy :
Odri GA; Institut National de la Santé et de la Recherche Médicale U957, Nantes, France.
Dumoucel S
Picarda G
Battaglia S
Lamoureux F
Corradini N
Rousseau J
Tirode F
Laud K
Delattre O
Gouin F
Heymann D
Redini F
Pokaż więcej
Źródło :
Cancer research [Cancer Res] 2010 Oct 01; Vol. 70 (19), pp. 7610-9. Date of Electronic Publication: 2010 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Bone Neoplasms/*drug therapy
Diphosphonates/*pharmacology
Imidazoles/*pharmacology
Sarcoma, Ewing/*drug therapy
Animals ; Apoptosis/drug effects ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/analogs & derivatives ; Diphosphonates/administration & dosage ; Drug Synergism ; Humans ; Ifosfamide/administration & dosage ; Imidazoles/administration & dosage ; Male ; Mice ; Mice, Nude ; Sarcoma, Ewing/pathology ; Zoledronic Acid
Czasopismo naukowe
Tytuł :
EWS-FLI1 inhibits TNFalpha-induced NFkappaB-dependent transcription in Ewing sarcoma cells.
Autorzy :
Lagirand-Cantaloube J; UMR8113 CNRS, LBPA, Ecole Normale Supérieure, Cachan, France. />Laud K
Lilienbaum A
Tirode F
Delattre O
Auclair C
Kryszke MH
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2010 Sep 03; Vol. 399 (4), pp. 705-10. Date of Electronic Publication: 2010 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Bone Neoplasms/*genetics
Oncogene Proteins, Fusion/*metabolism
Proto-Oncogene Protein c-fli-1/*metabolism
Sarcoma, Ewing/*genetics
Transcription Factor RelA/*metabolism
Cell Line, Tumor ; Electrophoretic Mobility Shift Assay ; Genes, Reporter ; Humans ; Luciferases/genetics ; RNA-Binding Protein EWS ; Transcription, Genetic ; Tumor Necrosis Factor-alpha/pharmacology
Czasopismo naukowe
Tytuł :
Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial.
Autorzy :
Le Deley MC; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Zimmermannplatz 10, 1090 Vienna, Austria.
Delattre O
Schaefer KL
Burchill SA
Koehler G
Hogendoorn PC
Lion T
Poremba C
Marandet J
Ballet S
Pierron G
Brownhill SC
Nesslböck M
Ranft A
Dirksen U
Oberlin O
Lewis IJ
Craft AW
Jürgens H
Kovar H
Pokaż więcej
Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2010 Apr 20; Vol. 28 (12), pp. 1982-8. Date of Electronic Publication: 2010 Mar 22.
Typ publikacji :
Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Bone Neoplasms/*genetics
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
Sarcoma, Ewing/*genetics
Transcription Factors/*genetics
Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biopsy ; Bone Neoplasms/mortality ; Bone Neoplasms/pathology ; Bone Neoplasms/therapy ; Chi-Square Distribution ; Disease Progression ; Europe ; Female ; Genetic Predisposition to Disease ; Humans ; Kaplan-Meier Estimate ; Male ; Neoplasm Recurrence, Local ; Paraffin Embedding ; Phenotype ; Proportional Hazards Models ; Prospective Studies ; RNA-Binding Protein EWS ; Radiotherapy, Adjuvant ; Reverse Transcriptase Polymerase Chain Reaction ; Risk Assessment ; Risk Factors ; Sarcoma, Ewing/mortality ; Sarcoma, Ewing/secondary ; Sarcoma, Ewing/therapy ; Stem Cell Transplantation ; Time Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Preclinical evidence that use of TRAIL in Ewing's sarcoma and osteosarcoma therapy inhibits tumor growth, prevents osteolysis, and increases animal survival.
Autorzy :
Picarda G; Institut National de la Sante et de la Recherche Medicale UMR_S 957, Université de Nantes EA 3822, Nantes Atlantique Universités, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, France.
Lamoureux F
Geffroy L
Delepine P
Montier T
Laud K
Tirode F
Delattre O
Heymann D
Rédini F
Pokaż więcej
Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2010 Apr 15; Vol. 16 (8), pp. 2363-74. Date of Electronic Publication: 2010 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Bone Neoplasms/*therapy
Lung Neoplasms/*therapy
Osteolysis/*prevention & control
Osteosarcoma/*therapy
Sarcoma, Ewing/*therapy
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Blotting, Western ; Bone Neoplasms/mortality ; Bone Neoplasms/pathology ; Cell Proliferation ; Child ; Drug Evaluation, Preclinical ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Gene Expression Profiling ; Humans ; Immunoenzyme Techniques ; Lung Neoplasms/mortality ; Lung Neoplasms/secondary ; Male ; Mice ; Mice, Inbred C3H ; Mice, Nude ; Oligonucleotide Array Sequence Analysis ; Osteosarcoma/mortality ; Osteosarcoma/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Sarcoma, Ewing/mortality ; Sarcoma, Ewing/pathology ; Survival Rate ; TNF-Related Apoptosis-Inducing Ligand/genetics ; Transgenes/physiology
Czasopismo naukowe
Tytuł :
[Stem cells and connective-tissue tumors: Ewing's sarcoma].
Autorzy :
Tirode F; U830 Inserm, institut Curie, 26, rue d'Ulm, 75248 Paris, France. />Delattre O
Pokaż więcej
Transliterated Title :
Cellules souches et tumeurs conjonctives : le sarcome d'Ewing.
Źródło :
Annales de pathologie [Ann Pathol] 2008 Nov; Vol. 28 Spec No 1 (1), pp. S33-4. Date of Electronic Publication: 2008 Oct 11.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*pathology
Sarcoma, Ewing/*pathology
Adolescent ; Animals ; Biomarkers, Tumor/analysis ; Bone Marrow Cells/pathology ; Cell Lineage ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Humans ; Immunophenotyping ; Mesoderm/pathology ; Mice ; Mice, Nude ; Neoplastic Stem Cells/transplantation ; Oncogene Proteins, Fusion/antagonists & inhibitors ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/physiology ; Proto-Oncogene Protein c-fli-1 ; RNA Interference ; RNA-Binding Protein EWS ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics ; Transcription Factors/physiology ; Transplantation, Heterologous ; Tumor Cells, Cultured ; Young Adult
Czasopismo naukowe
Tytuł :
[Ewing's tumours, genetic and cellular aspects].
Autorzy :
Delattre O
Pokaż więcej
Transliterated Title :
Tumeurs d'Ewing, aspects génétiques et cellulaires.
Źródło :
Pathologie-biologie [Pathol Biol (Paris)] 2008 Jul; Vol. 56 (5), pp. 257-9. Date of Electronic Publication: 2008 May 15.
Typ publikacji :
Editorial
MeSH Terms :
Translocation, Genetic*
Bone Neoplasms/*genetics
Oncogene Proteins, Fusion/*physiology
Proto-Oncogene Protein c-fli-1/*physiology
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
Bone Neoplasms/pathology ; Cell Transformation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Mesenchymal Stem Cells/pathology ; Neoplastic Stem Cells/pathology ; Oncogene Proteins, Fusion/genetics ; Proto-Oncogene Protein c-fli-1/genetics ; Sarcoma, Ewing/pathology ; Transcription Factors/genetics ; Transcription Factors/physiology
Opinia redakcyjna
Tytuł :
Rapid development of an osteosarcoma after surgical resection of an osteochondroma.
Autorzy :
Gomez-Brouchet A; Centre Hospitalier Universitaire, Hôpital des Enfants, Toulouse 3, France.
Accadbled F
Rubie H
Janka D Jr
Castex MP
Thuille B
Delattre O
Laurell H
Baunin C
de Gauzy JS
Pokaż więcej
Źródło :
Journal of pediatric orthopedics [J Pediatr Orthop] 2007 Sep; Vol. 27 (6), pp. 640-2.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Nucleic Acid Hybridization*
Bone Neoplasms/*etiology
Osteochondroma/*complications
Osteosarcoma/*etiology
Bone Neoplasms/diagnostic imaging ; Child ; Disease Progression ; Female ; Genome, Human ; Humans ; Neovascularization, Pathologic ; Osteochondroma/diagnostic imaging ; Osteochondroma/surgery ; Osteosarcoma/diagnostic imaging ; Radiography
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies