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Wyszukujesz frazę ""Dendritic spines"" wg kryterium: Temat


Tytuł :
Neonatal Isoflurane Anesthesia or Disruption of Postsynaptic Density-95 Protein Interactions Change Dendritic Spine Densities and Cognitive Function in Juvenile Mice.
Autorzy :
Schaefer ML
Perez PJ
Wang M
Gray C
Krall C
Sun X
Hunter E
Skinner J
Johns RA
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Źródło :
Anesthesiology [Anesthesiology] 2020 Oct 01; Vol. 133 (4), pp. 812-823.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Anesthetics, Inhalation/*toxicity
Cognition/*drug effects
Dendritic Spines/*drug effects
Disks Large Homolog 4 Protein/*antagonists & inhibitors
Isoflurane/*toxicity
Animals ; Animals, Newborn ; Cognition/physiology ; Dendritic Spines/pathology ; Dendritic Spines/physiology ; Disks Large Homolog 4 Protein/physiology ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Organ Culture Techniques ; Peptides/pharmacology ; Post-Synaptic Density/drug effects ; Post-Synaptic Density/pathology ; Post-Synaptic Density/physiology
Czasopismo naukowe
Tytuł :
Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function.
Autorzy :
Zaccard CR; Department of Physiology, Northwestern University, Chicago, IL 60611, USA.
Shapiro L; Department of Physiology, Northwestern University, Chicago, IL 60611, USA.
Martin-de-Saavedra MD; Department of Physiology, Northwestern University, Chicago, IL 60611, USA.
Pratt C; Department of Physiology, Northwestern University, Chicago, IL 60611, USA.
Myczek K; Department of Physiology, Northwestern University, Chicago, IL 60611, USA.
Song A; Department of Physiology, Northwestern University, Chicago, IL 60611, USA.
Forrest MP; Department of Physiology, Northwestern University, Chicago, IL 60611, USA.
Penzes P; Department of Physiology, Northwestern University, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL 60611, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Aug 05; Vol. 107 (3), pp. 522-537.e6. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Video-Audio Media
MeSH Terms :
Dendritic Spines/*ultrastructure
Guanine Nucleotide Exchange Factors/*metabolism
Post-Synaptic Density/*ultrastructure
Pyramidal Cells/*ultrastructure
Synapses/*ultrastructure
Animals ; Calcium/metabolism ; Cerebral Cortex/cytology ; Dendritic Spines/metabolism ; Dendritic Spines/physiology ; Imaging, Three-Dimensional ; Mice ; Microscopy, Confocal ; Post-Synaptic Density/physiology ; Pyramidal Cells/physiology ; Receptors, N-Methyl-D-Aspartate/agonists ; Spatio-Temporal Analysis ; Synapses/physiology
Czasopismo naukowe
Tytuł :
Structural LTP: from synaptogenesis to regulated synapse enlargement and clustering.
Autorzy :
Harris KM; University of Texas at Austin, United States. Electronic address: .
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Źródło :
Current opinion in neurobiology [Curr Opin Neurobiol] 2020 Aug; Vol. 63, pp. 189-197. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Dendritic Spines*
Long-Term Potentiation*
Cluster Analysis ; Hippocampus ; Neuronal Plasticity ; Synapses
Czasopismo naukowe
Tytuł :
Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake.
Autorzy :
Seyer B; Faculty of Biomedical and Psychological Sciences, Department of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Diwakarla S; The Beijer Laboratory, Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, BMC, Uppsala, Sweden.
Burns P; Faculty of Biomedical and Psychological Sciences, Department of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Hallberg A; Department of Medicinal Chemistry, Uppsala University, BMC, Uppsala, Sweden.
Grӧnbladh A; The Beijer Laboratory, Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, BMC, Uppsala, Sweden.
Hallberg M; The Beijer Laboratory, Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, BMC, Uppsala, Sweden.
Chai SY; Faculty of Biomedical and Psychological Sciences, Department of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 May; Vol. 153 (4), pp. 485-494. Date of Electronic Publication: 2019 Oct 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cystinyl Aminopeptidase/*antagonists & inhibitors
Cystinyl Aminopeptidase/*metabolism
Dendritic Spines/*metabolism
Glucose/*metabolism
Animals ; Biological Transport/drug effects ; Biological Transport/physiology ; Cells, Cultured ; Dendritic Spines/drug effects ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; Female ; Male ; Pregnancy ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Impaired actin dynamics and suppression of Shank2-mediated spine enlargement in cortactin knockout mice.
Autorzy :
Tanaka S; Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-0033, Japan.
Masuda Y; Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-0033, Japan.
Harada A; Department of Cell Biology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Okabe S; Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-0033, Japan.
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Źródło :
Microscopy (Oxford, England) [Microscopy (Oxf)] 2020 Mar 09; Vol. 69 (1), pp. 44-52.
Typ publikacji :
Journal Article
MeSH Terms :
Actins/*physiology
Cortactin/*genetics
Dendritic Spines/*physiology
Nerve Tissue Proteins/*genetics
Neurons/*physiology
Animals ; Cells, Cultured ; Dendritic Spines/ultrastructure ; Hippocampus ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Time-Lapse Imaging
Czasopismo naukowe
Tytuł :
Methamphetamine Learning Induces Persistent and Selective Nonmuscle Myosin II-Dependent Spine Motility in the Basolateral Amygdala.
Autorzy :
Young EJ; Departments of Molecular Medicine, and.; Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458.
Lin H; Departments of Molecular Medicine, and.
Kamenecka TM; Departments of Molecular Medicine, and.
Rumbaugh G; Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458 .
Miller CA; Departments of Molecular Medicine, and .; Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Mar 25; Vol. 40 (13), pp. 2695-2707. Date of Electronic Publication: 2020 Feb 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Association Learning/*drug effects
Basolateral Nuclear Complex/*metabolism
Central Nervous System Stimulants/*pharmacology
Dendritic Spines/*metabolism
Methamphetamine/*pharmacology
Neurons/*metabolism
Nonmuscle Myosin Type IIB/*metabolism
Animals ; Basolateral Nuclear Complex/drug effects ; Conditioning, Operant/drug effects ; Dendritic Spines/drug effects ; Female ; Male ; Mice ; Neurons/drug effects
Czasopismo naukowe
Tytuł :
Dual-Component Structural Plasticity Mediated by αCaMKII Autophosphorylation on Basal Dendrites of Cortical Layer 2/3 Neurones.
Autorzy :
Seaton G; School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom, and.
Hodges G; School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom, and.
de Haan A; School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom, and.
Grewal A; School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom, and.
Pandey A; School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom, and.
Kasai H; Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Fox K; School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom, and .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Mar 11; Vol. 40 (11), pp. 2228-2245. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*physiology
Dendritic Spines/*physiology
Neuronal Plasticity/*physiology
Neurons/*enzymology
Sensory Deprivation/*physiology
Somatosensory Cortex/*physiopathology
Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/deficiency ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Cell Size ; Dendritic Spines/ultrastructure ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/ultrastructure ; Phosphorylation ; Protein Processing, Post-Translational ; Skin Window Technique ; Somatosensory Cortex/cytology ; Somatosensory Disorders/physiopathology ; Vibrissae/injuries ; Vibrissae/innervation
Czasopismo naukowe
Tytuł :
A Novel Mechanism Underlying Activity-Dependent Pruning in Postnatal Prefrontal Cortex.
Autorzy :
Auger ML; Department of Anatomy and Cell Biology, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60612 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Mar 11; Vol. 40 (11), pp. 2186-2188.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Dendritic Spines*
Semaphorins*
Animals ; Mice ; Prefrontal Cortex ; Pyramidal Cells
Czasopismo naukowe
Tytuł :
Dopamine D2 receptors in discrimination learning and spine enlargement.
Autorzy :
Iino Y; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan.
Sawada T; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan.
Yamaguchi K; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan.
Tajiri M; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan.
Ishii S; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan.; Graduate School of Informatics, Kyoto University, Kyoto, Japan.
Kasai H; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. .; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan. .
Yagishita S; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. .; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan. .
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Źródło :
Nature [Nature] 2020 Mar; Vol. 579 (7800), pp. 555-560. Date of Electronic Publication: 2020 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dendritic Spines/*physiology
Discrimination Learning/*physiology
Receptors, Dopamine D2/*metabolism
Animals ; Calcium/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Conditioning, Classical/drug effects ; Dendritic Spines/drug effects ; Discrimination Learning/drug effects ; Dopamine/metabolism ; Dopamine D2 Receptor Antagonists/pharmacology ; Extinction, Psychological/drug effects ; Male ; Methamphetamine/antagonists & inhibitors ; Methamphetamine/pharmacology ; Mice ; Neuronal Plasticity ; Neurons/drug effects ; Neurons/metabolism ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Optogenetics ; Receptor, Adenosine A2A/metabolism ; Receptors, Dopamine D1/metabolism ; Reward ; Signal Transduction/drug effects ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Glucocorticoid receptors modulate dendritic spine plasticity and microglia activity in an animal model of Alzheimer's disease.
Autorzy :
Pedrazzoli M; University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Verona, Italy.
Losurdo M; University of Milano-Bicocca, School of Medicine and Surgery, Milan, Italy.
Paolone G; University of Verona, Department of Diagnostics and Public Health, Verona, Italy.
Medelin M; University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Verona, Italy.
Jaupaj L; University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Verona, Italy.
Cisterna B; University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Verona, Italy.
Slanzi A; University of Verona, Department of Medicine, Verona, Italy.
Malatesta M; University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Verona, Italy.
Coco S; University of Milano-Bicocca, School of Medicine and Surgery, Milan, Italy.
Buffelli M; University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Verona, Italy. Electronic address: .
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Źródło :
Neurobiology of disease [Neurobiol Dis] 2019 Dec; Vol. 132, pp. 104568. Date of Electronic Publication: 2019 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*metabolism
Dendritic Spines/*pathology
Microglia/*pathology
Neuronal Plasticity/*physiology
Receptors, Glucocorticoid/*metabolism
Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/genetics ; Animals ; Anti-Inflammatory Agents/pharmacology ; CA1 Region, Hippocampal/drug effects ; CA1 Region, Hippocampal/metabolism ; CA1 Region, Hippocampal/pathology ; Dendritic Spines/drug effects ; Dendritic Spines/metabolism ; Dexamethasone/pharmacology ; Disease Models, Animal ; Hormone Antagonists/pharmacology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/drug effects ; Microglia/metabolism ; Neuronal Plasticity/drug effects ; Presenilin-1/genetics ; Receptors, Glucocorticoid/drug effects ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility.
Autorzy :
Washburn HR; Department of Neuroscience and Jefferson Center for Synaptic Biology, Thomas Jefferson University, 233 South 10th Street, Bluemle Life Sciences Building, Room 324, Philadelphia, PA, 19107, USA.
Xia NL; Department of Neuroscience and Jefferson Center for Synaptic Biology, Thomas Jefferson University, 233 South 10th Street, Bluemle Life Sciences Building, Room 324, Philadelphia, PA, 19107, USA.; Department of Neurobiology, University of Chicago, 924 East 57th street, JFKR212, Chicago, IL, 60637, USA.
Zhou W; Department of Neuroscience and Jefferson Center for Synaptic Biology, Thomas Jefferson University, 233 South 10th Street, Bluemle Life Sciences Building, Room 324, Philadelphia, PA, 19107, USA.
Mao YT; Department of Neuroscience and Jefferson Center for Synaptic Biology, Thomas Jefferson University, 233 South 10th Street, Bluemle Life Sciences Building, Room 324, Philadelphia, PA, 19107, USA.
Dalva MB; Department of Neuroscience and Jefferson Center for Synaptic Biology, Thomas Jefferson University, 233 South 10th Street, Bluemle Life Sciences Building, Room 324, Philadelphia, PA, 19107, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jan 29; Vol. 11 (1), pp. 570. Date of Electronic Publication: 2020 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Dendritic Spines*/chemistry
Dendritic Spines*/genetics
Dendritic Spines*/metabolism
Receptor, EphB2/*chemistry
Receptor, EphB2/*metabolism
Receptors, N-Methyl-D-Aspartate/*chemistry
Receptors, N-Methyl-D-Aspartate/*metabolism
Synapses/*metabolism
Animals ; Biophysics ; Glycosylation ; HEK293 Cells ; Humans ; Ion Channels ; Mice ; Models, Molecular ; Nervous System/chemistry ; Nervous System/metabolism ; Neurons/chemistry ; Neurons/metabolism ; Neurosciences ; Protein Conformation ; Protein Interaction Domains and Motifs ; Receptor, EphB2/genetics ; Tyrosine/chemistry ; Tyrosine/metabolism
Czasopismo naukowe
Tytuł :
Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines.
Autorzy :
Ali F; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06511, USA.
Gerhard DM; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06511, USA.
Sweasy K; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06511, USA.
Pothula S; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06511, USA.
Pittenger C; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06511, USA.; Child Study Center, Yale University School of Medicine, New Haven, CT, 06511, USA.
Duman RS; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06511, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06511, USA.
Kwan AC; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06511, USA. .; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06511, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jan 07; Vol. 11 (1), pp. 72. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Dendritic Spines/*drug effects
Ketamine/*administration & dosage
Prefrontal Cortex/*drug effects
Animals ; Dendritic Spines/genetics ; Dendritic Spines/metabolism ; Interneurons/drug effects ; Interneurons/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Prefrontal Cortex/metabolism ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism
Czasopismo naukowe
Tytuł :
Cranial irradiation mediated spine loss is sex-specific and complement receptor-3 dependent in male mice.
Autorzy :
Hinkle JJ; Department of Neuroscience and Del Monte Neuroscience Institute, University of Rochester School of Medicine & Dentistry, Rochester, New York, 14642, USA.
Olschowka JA; Department of Neuroscience and Del Monte Neuroscience Institute, University of Rochester School of Medicine & Dentistry, Rochester, New York, 14642, USA.
Love TM; Department of Biostatistics and Computational Biology, University of Rochester School of Medicine & Dentistry, Rochester, New York, 14642, USA.
Williams JP; Department of Environmental Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York, 14642, USA.
O'Banion MK; Department of Neuroscience and Del Monte Neuroscience Institute, University of Rochester School of Medicine & Dentistry, Rochester, New York, 14642, USA. .; Department of Neurology, University of Rochester School of Medicine & Dentistry, Rochester, New York, 14642, USA. .
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Źródło :
Scientific reports [Sci Rep] 2019 Dec 11; Vol. 9 (1), pp. 18899. Date of Electronic Publication: 2019 Dec 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cranial Irradiation*
Dendritic Spines/*radiation effects
Hippocampus/*radiation effects
Microglia/*radiation effects
Receptors, Complement/*metabolism
Animals ; Cell Shape/radiation effects ; Dendritic Spines/metabolism ; Dendritic Spines/pathology ; Female ; Hippocampus/pathology ; Male ; Mice ; Mice, Knockout ; Microglia/pathology ; Receptors, Complement/genetics ; Sex Factors
Czasopismo naukowe
Tytuł :
PINK1 Silencing Modifies Dendritic Spine Dynamics of Mouse Hippocampal Neurons.
Autorzy :
Hernández CJ; Departamento de Patología, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogotá DC, Colombia.
Báez-Becerra C; Departamento de Patología, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogotá DC, Colombia.
Contreras-Zárate MJ; Departamento de Patología, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogotá DC, Colombia.
Arboleda H
Arboleda G; Departamento de Patología, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogotá DC, Colombia. .
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Źródło :
Journal of molecular neuroscience : MN [J Mol Neurosci] 2019 Dec; Vol. 69 (4), pp. 570-579. Date of Electronic Publication: 2019 Sep 05.
Typ publikacji :
Journal Article
MeSH Terms :
Neuronal Plasticity*
Dendritic Spines/*metabolism
Protein Kinases/*metabolism
Animals ; Cells, Cultured ; Dendritic Spines/ultrastructure ; Disks Large Homolog 4 Protein/metabolism ; GTPase-Activating Proteins/genetics ; GTPase-Activating Proteins/metabolism ; Hippocampus/cytology ; Hippocampus/metabolism ; Mice ; Mice, Inbred C57BL ; Nerve Tissue Proteins/metabolism ; Protein Kinases/genetics ; Receptors, Glutamate/genetics ; Receptors, Glutamate/metabolism ; rho-Associated Kinases/genetics ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Tytuł :
ICAM5 as a Novel Target for Treating Cognitive Impairment in Fragile X Syndrome.
Autorzy :
Pei YP; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
Wang YY; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
Liu D; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
Lei HY; Department of Pathophysiology, School of Basic Medicine and The Collaborative Innovation Center for Brain Science, Key Laboratory of Hubei Province and Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China, and.
Yang ZH; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
Zhang ZW; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
Han M; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
Cheng K; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
Chen YS; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
Li JQ; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
Cheng GR; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
Xu L; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
Wu QM; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.
McClintock SM; Brain Science and Advanced Technology Institute.; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas 75390.
Yang Y; Department of Pathophysiology, School of Basic Medicine and The Collaborative Innovation Center for Brain Science, Key Laboratory of Hubei Province and Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China, and.
Zhang Y; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, and Key Laboratory for Neuroscience, Ministry of Education of China and National Committee of Health and Family Planning of China, Peking University, Beijing 100191, People's Republic of China.
Zeng Y; Brain Science and Advanced Technology Institute, .; Hubei Province Key Laboratory of Occupational Hazard Identification and Control.; Big Data Science and Engineering Research Institute, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Feb 05; Vol. 40 (6), pp. 1355-1365. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cognitive Dysfunction/*metabolism
Dendritic Spines/*metabolism
Fragile X Syndrome/*metabolism
Gene Expression Regulation/*physiology
Membrane Glycoproteins/*metabolism
Nerve Tissue Proteins/*metabolism
Animals ; Cognitive Dysfunction/genetics ; Dendritic Spines/pathology ; Fragile X Mental Retardation Protein/genetics ; Fragile X Mental Retardation Protein/metabolism ; Fragile X Syndrome/complications ; Fragile X Syndrome/genetics ; Male ; Mice ; Mice, Knockout ; Neurogenesis/genetics
Czasopismo naukowe
Tytuł :
Dendritic Spines in Alzheimer's Disease: How the Actin Cytoskeleton Contributes to Synaptic Failure.
Autorzy :
Pelucchi S; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
Stringhi R; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
Marcello E; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 30; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Actin Cytoskeleton/*metabolism
Alzheimer Disease/*pathology
Dendritic Spines/*pathology
Synapses/*pathology
Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Animals ; Dendritic Spines/metabolism ; Humans ; Signal Transduction ; Synapses/metabolism ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Synaptic Odyssey.
Autorzy :
Harris KM; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, Texas 78712 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Jan 02; Vol. 40 (1), pp. 61-80.
Typ publikacji :
Journal Article; Personal Narrative
MeSH Terms :
Dendritic Spines/*ultrastructure
Microscopy, Electron/*methods
Synapses/*physiology
Synaptic Transmission/*physiology
Animals ; Dendritic Spines/physiology ; Electric Stimulation ; Endosomes/ultrastructure ; Hippocampus/growth & development ; Hippocampus/ultrastructure ; Humans ; Imaging, Three-Dimensional ; Long-Term Potentiation/physiology ; Neuroglia/physiology ; Neuroglia/ultrastructure ; Polyribosomes/ultrastructure ; Rats ; Specimen Handling/methods
Czasopismo naukowe
Tytuł :
Deficits in developmental neurogenesis and dendritic spine maturation in mice lacking the serine protease inhibitor neuroserpin.
Autorzy :
Hermann M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Reumann R; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Schostak K; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Kement D; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Gelderblom M; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Bernreuther C; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Frischknecht R; Department of Biology and Animal Physiology, Friedrich Alexander University Erlangen-Nürnberg, Staudtstrasse 5, 91058 Erlangen, Germany.
Schipanski A; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Marik S; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Krasemann S; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Sepulveda-Falla D; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Schweizer M; Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Falkenried 94, 20251 Hamburg, Germany.
Magnus T; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Glatzel M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Galliciotti G; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. Electronic address: .
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Źródło :
Molecular and cellular neurosciences [Mol Cell Neurosci] 2020 Jan; Vol. 102, pp. 103420. Date of Electronic Publication: 2019 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neurogenesis*
Dendritic Spines/*metabolism
Neuropeptides/*metabolism
Serpins/*metabolism
Animals ; Cell Line ; Cell Proliferation ; Cells, Cultured ; Dendritic Spines/physiology ; Hippocampus/cytology ; Hippocampus/embryology ; Hippocampus/metabolism ; Mice ; Mice, Inbred C57BL ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Neural Stem Cells/physiology ; Neuropeptides/genetics ; Serpins/genetics
Czasopismo naukowe
Tytuł :
Reply to 'Only negligible deviations from electroneutrality are expected in dendritic spines'.
Autorzy :
Holcman D; Group of Data Modeling and Computational Biology, IBENS-PSL, École Normale Supérieure, Paris, France. .; Churchill College, DAMPT, University of Cambridge, Cambridge, UK. .
Yuste R; Neurotechnology Center, Department of Biological Sciences and Neuroscience, Columbia University, New York, New York, USA.
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Źródło :
Nature reviews. Neuroscience [Nat Rev Neurosci] 2020 Jan; Vol. 21 (1), pp. 54-55.
Typ publikacji :
Letter; Comment
MeSH Terms :
Dendritic Spines*
Neurons*
Synapses
Opinia redakcyjna
Tytuł :
Only negligible deviations from electroneutrality are expected in dendritic spines.
Autorzy :
Barbour B; Institut de biologie de l'École normale supérieure (IBENS), École normale supérieure, CNRS, INSERM, PSL University, Paris, France. .
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Źródło :
Nature reviews. Neuroscience [Nat Rev Neurosci] 2020 Jan; Vol. 21 (1), pp. 53.
Typ publikacji :
Letter; Comment
MeSH Terms :
Dendritic Spines*
Neurons*
Dendrites
Opinia redakcyjna

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