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Tytuł:
High throughput analysis of B cell dynamics and neutralizing antibody development during immunization with a novel clade C HIV-1 envelope.
Autorzy:
Mopuri R; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Welbourn S; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Charles T; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Ralli-Jain P; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.
Rosales D; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.
Burton S; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Aftab A; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.
Karunakaran K; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Pellegrini K; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Kilembe W; Center for Family Health Research in Zambia, Lusaka, Zambia.
Karita E; Center for Family Health Research, Kigali, Rwanda.
Gnanakaran S; Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Upadhyay AA; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Bosinger SE; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Derdeyn CA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America.; Infectious Diseases and Translational Medicine Unit, Washington National Primate Research Center, University of Washington, Seattle, Washington, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Oct 25; Vol. 19 (10), pp. e1011717. Date of Electronic Publication: 2023 Oct 25 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*
HIV Infections*
HIV Seropositivity*
AIDS Vaccines*
Animals ; Antibodies, Neutralizing ; Macaca mulatta ; HIV Antibodies ; Immunization ; env Gene Products, Human Immunodeficiency Virus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence.
Autorzy:
Welbourn S; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Chakraborty S; Theoretical Biology and Biophysics Group, Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Yang JE; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Gleinich AS; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America.
Gangadhara S; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Khan S; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Ferrebee C; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Yagnik B; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Burton S; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Charles T; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Smith SA; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Williams D; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Mopuri R; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Upadhyay AA; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Thompson J; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Price MA; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America.; International AIDS Vaccine Initiative, New York city, New York, United States of America.
Wang S; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America.
Qin Z; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America.
Shen X; Department of Surgery, Duke University, Durham, North Carolina, United States of America.
Williams LD; Department of Surgery, Duke University, Durham, North Carolina, United States of America.
Eisel N; Department of Surgery, Duke University, Durham, North Carolina, United States of America.
Peters T; Department of Surgery, Duke University, Durham, North Carolina, United States of America.
Zhang L; Department of Surgery, Duke University, Durham, North Carolina, United States of America.
Kilembe W; Center for Family Health Research in Zambia (CFHRZ), Lusaka, Zambia.
Karita E; Projet San Francisco, Kigali, Rwanda.
Tomaras GD; Department of Surgery, Duke University, Durham, North Carolina, United States of America.
Bosinger SE; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Amara RR; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America.
Azadi P; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America.
Wright ER; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Gnanakaran S; Theoretical Biology and Biophysics Group, Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Derdeyn CA; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 May 03; Vol. 18 (5), pp. e1010488. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
AIDS Vaccines*
HIV Infections*/prevention & control
HIV-1*
Animals ; Antibodies, Neutralizing ; HIV Antibodies ; HIV Envelope Protein gp120 ; Humans ; Macaca mulatta ; env Gene Products, Human Immunodeficiency Virus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART.
Autorzy:
Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Atlanta, Georgia, United States of America.
Pereira Ribeiro S; Department of Pathology and Laboratory Medicine, Emory School of Medicine, Emory University, Atlanta, Georgia, United States of America.
Pagliuzza A; Centre de Recherche du CHUM and Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, QC, Canada.
Ghneim K; Department of Pathology and Laboratory Medicine, Emory School of Medicine, Emory University, Atlanta, Georgia, United States of America.
Khan A; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America.
Ryan E; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Atlanta, Georgia, United States of America.
Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Atlanta, Georgia, United States of America.
King CT; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Atlanta, Georgia, United States of America.
Welbourn S; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Micci L; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Atlanta, Georgia, United States of America.
Aldrete S; Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Delman KA; Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia, United States of America.
Stuart T; Emory Vaccine Center, Emory University, Hope Clinic, Decatur, Georgia, United States of America.
Lowe M; Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia, United States of America.
Brenchley JM; Barrier Immunity Section, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
Derdeyn CA; Department of Pathology and Laboratory Medicine, Emory School of Medicine, Emory University, Atlanta, Georgia, United States of America.; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Easley K; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America.
Sekaly RP; Department of Pathology and Laboratory Medicine, Emory School of Medicine, Emory University, Atlanta, Georgia, United States of America.
Chomont N; Centre de Recherche du CHUM and Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, QC, Canada.
Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory School of Medicine, Emory University, Atlanta, Georgia, United States of America.
Marconi VC; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Atlanta, Georgia, United States of America.; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 Aug 27; Vol. 17 (8), pp. e1009825. Date of Electronic Publication: 2021 Aug 27 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Homeostasis*
Anti-Retroviral Agents/*pharmacology
CD4-Positive T-Lymphocytes/*immunology
Cytokines/*metabolism
HIV Infections/*virology
T-Lymphocyte Subsets/*immunology
CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/virology ; DNA, Viral ; Female ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV-1/immunology ; Humans ; Immunologic Memory/immunology ; Male ; Middle Aged ; T-Lymphocyte Subsets/drug effects ; T-Lymphocyte Subsets/virology ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection.
Autorzy:
Charles TP; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Burton SL; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Arunachalam PS; Departments of Pathology, and Microbiology and Immunology, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, United States of America.
Cottrell CA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Sewall LM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Bollimpelli VS; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Gangadhara S; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Dey AK; International AIDS Vaccine Initiative, New York, New York, United States of America.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Shaw GM; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Hunter E; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Amara RR; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America.
Pulendran B; Departments of Pathology, and Microbiology and Immunology, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, United States of America.
van Gils MJ; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Derdeyn CA; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 Feb 08; Vol. 17 (2), pp. e1009257. Date of Electronic Publication: 2021 Feb 08 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Neutralizing/*immunology
HIV Antibodies/*immunology
HIV-1/*immunology
Polysaccharides/*immunology
Simian Acquired Immunodeficiency Syndrome/*prevention & control
Simian Immunodeficiency Virus/*immunology
env Gene Products, Human Immunodeficiency Virus/*immunology
Animals ; Epitopes/immunology ; Female ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Immunization ; Macaca mulatta ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Vaccination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth.
Autorzy:
Smith SA; Yerkes National Primate Research Center, Emory University Atlanta, Georgia, United States of America.; Emory Vaccine Center, Emory University Atlanta, Georgia, United States of America.
Burton SL; Yerkes National Primate Research Center, Emory University Atlanta, Georgia, United States of America.; Emory Vaccine Center, Emory University Atlanta, Georgia, United States of America.
Kilembe W; Zambia Emory HIV Research Project, Lusaka, Ndola and Kitwe, Zambia.
Lakhi S; Zambia Emory HIV Research Project, Lusaka, Ndola and Kitwe, Zambia.
Karita E; Projet San Francisco, Kigali, Rwanda.
Price M; International AIDS Vaccine Initiative (IAVI), New York, New York, United States of America.; UCSF Department of Epidemiology and Biostatistics, San Francisco, California, United States of America.
Allen S; Department of Pathology and Laboratory Medicine, Emory University Atlanta, Georgia, United States of America.
Hunter E; Yerkes National Primate Research Center, Emory University Atlanta, Georgia, United States of America.; Emory Vaccine Center, Emory University Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University Atlanta, Georgia, United States of America.
Derdeyn CA; Yerkes National Primate Research Center, Emory University Atlanta, Georgia, United States of America.; Emory Vaccine Center, Emory University Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University Atlanta, Georgia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2016 Nov 16; Vol. 12 (11), pp. e1005989. Date of Electronic Publication: 2016 Nov 16 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Neutralizing/*immunology
HIV Antibodies/*immunology
HIV Infections/*immunology
env Gene Products, Human Immunodeficiency Virus/*metabolism
Antibodies, Neutralizing/blood ; Glycosylation ; HIV Antibodies/blood ; HIV Infections/metabolism ; HIV-1/immunology ; HIV-1/metabolism ; Humans ; Neutralization Tests ; Polymerase Chain Reaction ; Rwanda ; Zambia ; env Gene Products, Human Immunodeficiency Virus/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of Glycosylation on an Immunodominant Region in the V1V2 Variable Domain of the HIV-1 Envelope gp120 Protein.
Autorzy:
Tian J; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.; Center for Biomolecular Biophysics, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America.
López CA; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Derdeyn CA; Department of Pathology and Laboratory Medicine and Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.
Jones MS; University of California Berkeley, School of Public Health, Berkeley, California, United States of America.
Pinter A; New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America.
Korber B; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Gnanakaran S; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2016 Oct 07; Vol. 12 (10), pp. e1005094. Date of Electronic Publication: 2016 Oct 07 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Glycosylation*
HIV Envelope Protein gp120/*chemistry
HIV Envelope Protein gp120/*immunology
Immunodominant Epitopes/*immunology
Single-Chain Antibodies/*chemistry
Single-Chain Antibodies/*immunology
Binding Sites ; Molecular Docking Simulation/methods ; Protein Binding ; Protein Domains/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A pathway to HIV-1 neutralization breadth.
Autorzy:
Smith SA; Yerkes National Primate Research Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
Derdeyn CA; Yerkes National Primate Research Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Nov; Vol. 21 (11), pp. 1246-7.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
AIDS Vaccines/*immunology
Antibodies, Neutralizing/*immunology
B-Lymphocytes/*immunology
HIV Antibodies/*immunology
HIV-1/*immunology
High-Throughput Nucleotide Sequencing ; Humans ; Superinfection/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes.
Autorzy:
Peters PJ; Program in Molecular Medicine and Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Biotech 2, 373 Plantation Street, Worcester, MA, 01605-2377, USA. .
Gonzalez-Perez MP; Program in Molecular Medicine and Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Biotech 2, 373 Plantation Street, Worcester, MA, 01605-2377, USA. .
Musich T; Program in Molecular Medicine and Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Biotech 2, 373 Plantation Street, Worcester, MA, 01605-2377, USA. .
Moore Simas TA; Department of Ob/Gyn, University of Massachusetts Memorial Health Care, 119 Belmont Street, Worcester, MA, 01605, USA. .
Lin R; School of Public Health and Health Sciences, University of Massachusetts, 411 Arnold House, 715 North Pleasant Street, Amherst, MA, 01003-9304, USA. .
Morse AN; Department of Ob/Gyn, University of Massachusetts Memorial Health Care, 119 Belmont Street, Worcester, MA, 01605, USA. .
Shattock RJ; Department of Medicine, St Mary's Campus, Imperial College, Medical School Building, London, W21PG, UK. .
Derdeyn CA; Department of Pathology and Laboratory Medicine, Emory Vaccine Center at Yerkes National Primate Center, Emory University, 954 Gatewood Road, Atlanta, GA, 30329, USA. .
Clapham PR; Program in Molecular Medicine and Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Biotech 2, 373 Plantation Street, Worcester, MA, 01605-2377, USA. .
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Źródło:
Retrovirology [Retrovirology] 2015 Jun 09; Vol. 12, pp. 48. Date of Electronic Publication: 2015 Jun 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Viral Tropism*
HIV-1/*physiology
T-Lymphocytes/*virology
env Gene Products, Human Immunodeficiency Virus/*metabolism
Cells, Cultured ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages.
Autorzy:
Musich T
O'Connell O
Gonzalez-Perez MP
Derdeyn CA
Peters PJ
Clapham PR
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Źródło:
Retrovirology [Retrovirology] 2015 Mar 14; Vol. 12, pp. 25. Date of Electronic Publication: 2015 Mar 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Viral Tropism*
Virus Internalization*
CD4-Positive T-Lymphocytes/*virology
HIV-1/*physiology
Macrophages/*virology
env Gene Products, Human Immunodeficiency Virus/*metabolism
Cells, Cultured ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients.
Autorzy:
Yue L; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Pfafferott KJ; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Baalwa J; Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America.
Conrod K; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Dong CC; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Chui C; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Rong R; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Claiborne DT; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Prince JL; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Tang J; Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America.
Ribeiro RM; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Cormier E; Human Immunology Laboratory, International AIDS Vaccine Initiative, London, United Kingdom.
Hahn BH; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Shaw GM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Karita E; Rwanda-Zambia HIV Research Project, Project San Francisco, Kigali, Rwanda.
Gilmour J; Human Immunology Laboratory, International AIDS Vaccine Initiative, London, United Kingdom.
Goepfert P; Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America.
Derdeyn CA; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Allen SA; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Borrow P; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Hunter E; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2015 Jan 08; Vol. 11 (1), pp. e1004565. Date of Electronic Publication: 2015 Jan 08 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Genetic Fitness*
HIV Infections/*diagnosis
HIV-1/*genetics
HIV-1/*immunology
Host-Pathogen Interactions/*immunology
T-Lymphocytes/*immunology
Adult ; Amino Acid Sequence ; Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/immunology ; Evolution, Molecular ; Female ; HEK293 Cells ; HIV Infections/genetics ; HIV Infections/immunology ; HIV Infections/transmission ; Host-Pathogen Interactions/genetics ; Humans ; Immune Evasion/genetics ; Male ; Molecular Sequence Data ; Phylogeny ; Prognosis ; Viral Load/genetics ; Virus Replication/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells.
Autorzy:
Micci L; Division of Microbiology & Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Alvarez X; Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, United States of America.
Iriele RI; Division of Microbiology & Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Ortiz AM; Division of Microbiology & Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Ryan ES; Division of Microbiology & Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.
McGary CS; Division of Microbiology & Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Deleage C; AIDS Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, Maryland, United States of America.
McAtee BB; Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, United States of America.
He T; Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Apetrei C; Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Easley K; Department of Biostatistics & Bioinformatics, Rollins School of Public Health, Atlanta, Georgia, United States of America.
Pahwa S; University of Miami Miller School of Medicine, Miami, Florida, United States of America.
Collman RG; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Derdeyn CA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Davenport MP; Centre for Vascular Research, University of New South Wales, Kensington, New South Wales, Australia.
Estes JD; AIDS Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, Maryland, United States of America.
Silvestri G; Division of Microbiology & Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, United States of America; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Lackner AA; Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, United States of America.
Paiardini M; Division of Microbiology & Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, United States of America; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2014 Oct 30; Vol. 10 (10), pp. e1004467. Date of Electronic Publication: 2014 Oct 30 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
CD4-Positive T-Lymphocytes/*virology
Simian Acquired Immunodeficiency Syndrome/*immunology
Simian Immunodeficiency Virus/*immunology
Animals ; CD4-Positive T-Lymphocytes/immunology ; Disease Models, Animal ; Female ; Lymphocyte Depletion ; Macaca mulatta ; Macrophages/immunology ; Macrophages/virology ; Microglia/immunology ; Microglia/virology ; Monocytes/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Viral Load ; Viremia
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques.
Autorzy:
Chahroudi A; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Cartwright E; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Lee ST; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Mavigner M; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Carnathan DG; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Lawson B; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Carnathan PM; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Hashempoor T; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Murphy MK; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Meeker T; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Ehnert S; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Souder C; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Else JG; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America; Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Cohen J; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Collman RG; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Vanderford TH; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Permar SR; Duke Human Vaccine Institute, Durham, North Carolina, United States of America.
Derdeyn CA; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America; Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Villinger F; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America; Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Silvestri G; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America; Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2014 Mar 06; Vol. 10 (3), pp. e1003958. Date of Electronic Publication: 2014 Mar 06 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
CD4-Positive T-Lymphocytes/*immunology
Cercocebus atys/*immunology
Macaca mulatta/*immunology
Milk/*virology
Simian Acquired Immunodeficiency Syndrome/*transmission
Animals ; Cercocebus atys/virology ; Female ; Lactation ; Macaca mulatta/virology ; Pregnancy ; Reverse Transcriptase Polymerase Chain Reaction ; Simian Acquired Immunodeficiency Syndrome/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo.
Autorzy:
Francella N
Elliott ST
Yi Y
Gwyn SE
Ortiz AM
Li B
Silvestri G
Paiardini M
Derdeyn CA
Collman RG; Department of Medicine, University of Pennsylvania Perelman School of Medicine, 522 Johnson Pavilion, 36th & Hamilton Walk, Philadelphia, PA, USA. .
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Źródło:
Retrovirology [Retrovirology] 2013 Nov 12; Vol. 10, pp. 133. Date of Electronic Publication: 2013 Nov 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Virus Attachment*
Receptors, CCR5/*metabolism
Receptors, Virus/*metabolism
Simian Immunodeficiency Virus/*physiology
Viral Envelope Proteins/*metabolism
Animals ; CD4 Antigens/metabolism ; Macaca mulatta ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Mutation ; Simian Immunodeficiency Virus/genetics ; Viral Envelope Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Viral escape from neutralizing antibodies in early subtype A HIV-1 infection drives an increase in autologous neutralization breadth.
Autorzy:
Murphy MK; Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, Georgia, United States of America.
Yue L
Pan R
Boliar S
Sethi A
Tian J
Pfafferot K
Karita E
Allen SA
Cormier E
Goepfert PA
Borrow P
Robinson JE
Gnanakaran S
Hunter E
Kong XP
Derdeyn CA
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Źródło:
PLoS pathogens [PLoS Pathog] 2013 Feb; Vol. 9 (2), pp. e1003173. Date of Electronic Publication: 2013 Feb 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Immune Evasion/*immunology
Amino Acid Sequence ; Antibodies, Neutralizing/chemistry ; Cross Reactions/immunology ; Female ; HIV Infections/virology ; HIV Seropositivity/immunology ; HIV Seropositivity/virology ; Humans ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Light Chains/immunology ; Male ; Molecular Sequence Data ; Protein Structure, Tertiary ; Sequence Alignment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A mechanistic understanding of allosteric immune escape pathways in the HIV-1 envelope glycoprotein.
Autorzy:
Sethi A; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Tian J
Derdeyn CA
Korber B
Gnanakaran S
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2013; Vol. 9 (5), pp. e1003046. Date of Electronic Publication: 2013 May 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Envelope Protein gp120*/chemistry
HIV Envelope Protein gp120*/metabolism
HIV Envelope Protein gp120*/physiology
HIV-1*/chemistry
HIV-1*/metabolism
HIV-1*/physiology
Molecular Dynamics Simulation*
Immune Evasion/*physiology
Binding Sites ; CD4 Antigens/chemistry ; CD4 Antigens/metabolism ; Computational Biology ; HIV Infections/virology ; Humans ; Principal Component Analysis ; Protein Conformation ; Reproducibility of Results ; Structural Homology, Protein
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
HIV-1 subtype C superinfected individuals mount low autologous neutralizing antibody responses prior to intrasubtype superinfection.
Autorzy:
Basu D; Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA, USA.
Kraft CS
Murphy MK
Campbell PJ
Yu T
Hraber PT
Irene C
Pinter A
Chomba E
Mulenga J
Kilembe W
Allen SA
Derdeyn CA
Hunter E
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Źródło:
Retrovirology [Retrovirology] 2012 Sep 20; Vol. 9, pp. 76. Date of Electronic Publication: 2012 Sep 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Antibodies, Neutralizing/*blood
HIV Antibodies/*blood
HIV Infections/*immunology
HIV-1/*immunology
Superinfection/*virology
Case-Control Studies ; Cell Line ; HIV Envelope Protein gp120/genetics ; HIV Envelope Protein gp120/immunology ; HIV Infections/blood ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Immunity, Humoral ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Molecular Sequence Data ; Peptide Fragments/immunology ; Phylogeography ; Sequence Analysis, DNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Timing and source of subtype-C HIV-1 superinfection in the newly infected partner of Zambian couples with disparate viruses.
Autorzy:
Kraft CS; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Basu D
Hawkins PA
Hraber PT
Chomba E
Mulenga J
Kilembe W
Khu NH
Derdeyn CA
Allen SA
Manigart O
Hunter E
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Źródło:
Retrovirology [Retrovirology] 2012 Mar 20; Vol. 9, pp. 22. Date of Electronic Publication: 2012 Mar 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Coinfection/*epidemiology
HIV Infections/*epidemiology
HIV-1/*classification
HIV-1/*isolation & purification
Adult ; Coinfection/virology ; Family Characteristics ; Genotype ; HIV Envelope Protein gp41/genetics ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Incidence ; Male ; Molecular Epidemiology ; Molecular Sequence Data ; Sequence Analysis, DNA ; Time Factors ; Zambia
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.
Autorzy:
Prince JL; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Claiborne DT
Carlson JM
Schaefer M
Yu T
Lahki S
Prentice HA
Yue L
Vishwanathan SA
Kilembe W
Goepfert P
Price MA
Gilmour J
Mulenga J
Farmer P
Derdeyn CA
Tang J
Heckerman D
Kaslow RA
Allen SA
Hunter E
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Źródło:
PLoS pathogens [PLoS Pathog] 2012; Vol. 8 (11), pp. e1003041. Date of Electronic Publication: 2012 Nov 29.
Typ publikacji:
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
HIV-1*/pathogenicity
HIV-1*/physiology
Polymorphism, Genetic*
CD4-Positive T-Lymphocytes/*immunology
HIV Infections/*immunology
Virus Replication/*immunology
gag Gene Products, Human Immunodeficiency Virus/*immunology
CD4-Positive T-Lymphocytes/virology ; Cell Line ; Female ; Follow-Up Studies ; Genome, Viral/genetics ; Genome, Viral/immunology ; HIV Infections/epidemiology ; HIV Infections/genetics ; Humans ; Male ; Mutation ; Virus Replication/genetics ; Zambia/epidemiology ; gag Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo.
Autorzy:
Riddick NE; Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
Hermann EA
Loftin LM
Elliott ST
Wey WC
Cervasi B
Taaffe J
Engram JC
Li B
Else JG
Li Y
Hahn BH
Derdeyn CA
Sodora DL
Apetrei C
Paiardini M
Silvestri G
Collman RG
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Źródło:
PLoS pathogens [PLoS Pathog] 2010 Aug 26; Vol. 6 (8), pp. e1001064. Date of Electronic Publication: 2010 Aug 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cercocebus atys/*genetics
Receptors, CCR5/*genetics
Simian Acquired Immunodeficiency Syndrome/*genetics
Simian Immunodeficiency Virus/*genetics
Amino Acid Sequence ; Animals ; Base Sequence ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line ; Cell Separation ; Flow Cytometry ; Genotype ; Humans ; Molecular Sequence Data ; Mutation ; Polymerase Chain Reaction ; Receptors, CCR5/biosynthesis ; Transfection ; Viral Load/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways.
Autorzy:
Rong R; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
Li B
Lynch RM
Haaland RE
Murphy MK
Mulenga J
Allen SA
Pinter A
Shaw GM
Hunter E
Robinson JE
Gnanakaran S
Derdeyn CA
Pokaż więcej
Źródło:
PLoS pathogens [PLoS Pathog] 2009 Sep; Vol. 5 (9), pp. e1000594. Date of Electronic Publication: 2009 Sep 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibody Diversity*
HIV Antibodies/*immunology
HIV Envelope Protein gp120/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Acute Disease ; Antibodies, Monoclonal/pharmacology ; Cell Line ; DNA Mutational Analysis ; HIV Envelope Protein gp120/drug effects ; HIV Envelope Protein gp120/genetics ; HIV Infections/drug therapy ; HIV-1/drug effects ; HIV-1/genetics ; Host-Pathogen Interactions ; Humans ; Mutation ; Neutralization Tests ; Virus Replication/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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