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Tytuł :
Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease.
Autorzy :
Peloso, GM
Nomura, A
Khera, AV
Chaffin, M
Won, H-H
Ardissino, D
Danesh, J
Schunkert, H
Wilson, JG
Samani, N
Erdmann, J
McPherson, R
Watkins, H
Saleheen, D
McCarthy, S
Teslovich, TM
Leader, JB
Kirchner, HL
Marrugat, J
Nohara, A
Kawashiri, M
Tada, H
Dewey, FE
Carey, DJ
Baras, A
Kathiresan, S
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Źródło :
12
Opis pliku :
Print
Tytuł :
Age and double product (systolic blood pressure x heart rate) reserve-adjusted modification of the Duke Treadmill Score nomogram in men.
Autorzy :
Rafie AHS (AUTHOR)
Dewey FE (AUTHOR)
Sungar GW (AUTHOR)
Ashley EA (AUTHOR)
Hadley D (AUTHOR)
Myers J (AUTHOR)
Froelicher VF (AUTHOR)
Sadrzadeh Rafie, Amir H (AUTHOR)
Dewey, Frederick E (AUTHOR)
Sungar, Gannon W (AUTHOR)
Ashley, Euan A (AUTHOR)
Hadley, David (AUTHOR)
Myers, Jonathan (AUTHOR)
Froelicher, Victor F (AUTHOR)
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Źródło :
American Journal of Cardiology. Nov2008, Vol. 102 Issue 10, p1407-1412. 6p.
Czasopismo naukowe
Tytuł :
Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants.
Autorzy :
Haggerty CM; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Damrauer SM; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA (S.M.D.).
Levin MG; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Birtwell D; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Carey DJ; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Golden AM; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Hartzel DN; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Hu Y; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Judy R; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Kelly MA; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Kember RL; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Lester Kirchner H; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Leader JB; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Liang L; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
McDermott-Roe C; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Babu A; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Morley M; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Nealy Z; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Person TN; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Pulenthiran A; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Small A; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Smelser DT; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Stahl RC; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Sturm AC; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Williams H; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Baras A; Regeneron Genetics Center, Tarrytown, NY (A. Baras, F.E.D.).
Margulies KB; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Cappola TP; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Dewey FE; Regeneron Genetics Center, Tarrytown, NY (A. Baras, F.E.D.).
Verma A; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Zhang X; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Correa A; Department of Medicine (A.C., M.E.H.), University of Mississippi Medical Center, Jackson.
Hall ME; Department of Medicine (A.C., M.E.H.), University of Mississippi Medical Center, Jackson.; Department of Physiology and Biophysics (M.E.H., J.G.W.), University of Mississippi Medical Center, Jackson.
Wilson JG; Department of Physiology and Biophysics (M.E.H., J.G.W.), University of Mississippi Medical Center, Jackson.
Ritchie MD; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Rader DJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
Murray MF; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Fornwalt BK; Geisinger, Danville, PA (C.M.H., D.J.C., A.M.G., D.N.H., Y.H., M.A.K., H.L.K., J.B.L., Z.N., T.N.P., A.P., D.T.S., R.C.S., A.C.S., M.F.M., B.K.F.).
Arany Z; Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D., M.G.L., D.B., R.J., R.L.K., L.L., C.M.-R., A. Babu, M.M., A.S., H.W., K.B.M., T.P.C., A.V., X.Z., M.D.R., D.J.R., Z.A.).
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Źródło :
Circulation [Circulation] 2019 Jul 02; Vol. 140 (1), pp. 42-54. Date of Electronic Publication: 2019 Jun 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Electronic Health Records*/trends
Connectin/*genetics
European Continental Ancestry Group/*genetics
Genetic Variation/*genetics
Genomics/*methods
Heart Diseases/*genetics
Adult ; Aged ; Cohort Studies ; Female ; Heart Diseases/diagnosis ; Humans ; Longitudinal Studies ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Autorzy :
Flannick J; Program in Metabolism, Broad Institute, Cambridge, MA, USA. .; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA. .; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. .; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA. .
Mercader JM; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Fuchsberger C; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Institute for Biomedicine, Eurac Research, Bolzano, Italy.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Udler MS; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Wessel J; Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.; Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN, USA.; Diabetes Translational Research Center, Indiana University, Indianapolis, IN, USA.
Teslovich TM; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Caulkins L; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.
Koesterer R; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.
Barajas-Olmos F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Blackwell TW; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Boerwinkle E; Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Brody JA; Cardiovascular Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Centeno-Cruz F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Chen L; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Chen S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Contreras-Cubas C; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Córdova E; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Cortes M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
DeFronzo RA; Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
Dolan L; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Drews KL; Biostatistics Center, George Washington University, Rockville, MD, USA.
Elliott A; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Floyd JS; Department of Medicine and Epidemiology, University of Washington, Seattle, WA, USA.
Gabriel S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Garay-Sevilla ME; Department of Medicine, The University of Chicago, Chicago, IL, USA.; Department of Human Genetics, The University of Chicago, Chicago, IL, USA.
García-Ortiz H; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Gross M; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Han S; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea.
Heard-Costa NL; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
Jackson AU; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Jørgensen ME; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.; Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland.
Kang HM; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Kelsey M; Biostatistics Center, George Washington University, Rockville, MD, USA.
Kim BJ; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea.
Koistinen HA; Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.; University of Helsinki and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland.
Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicin, Kuopio University Hospital, Kuopio, Finland.
Leader JB; Geisinger Health System, Danville, PA, USA.
Linneberg A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark.
Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Liu J; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Department of Clinical Science, University of Bergen, Bergen, Norway.
Manning AK; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Marcketta A; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Malacara-Hernandez JM; Department of Medicine, The University of Chicago, Chicago, IL, USA.; Department of Human Genetics, The University of Chicago, Chicago, IL, USA.
Martínez-Hernández A; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Matsuo K; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Mayer-Davis E; University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
Mendoza-Caamal E; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Mohlke KL; Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
Morrison AC; Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Ndungu A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Ng MCY; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
O'Dushlaine C; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Payne AJ; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Pihoker C; Seattle Children's Hospital, Seattle, WA, USA.
Post WS; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Preuss M; Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY, USA.
Psaty BM; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.
Vasan RS; National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Preventive Medicine & Epidemiology, Medicine, Boston University School of Medicine, Boston, MA, USA.
Rayner NW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Revilla-Monsalve C; Instituto Mexicano del Seguro Social SXXI, Mexico City, Mexico.
Robertson NR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Santoro N; Department of Pediatrics, Yale University, New Haven, CT, USA.
Schurmann C; Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY, USA.
So WY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.
Soberón X; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Stringham HM; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Strom TM; Institute of Human Genetics, Technische Universität München, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.
Thameem F; Health Science Center, Department of Biochemistry, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Tomlinson B; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Torres JM; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Tracy RP; Department of Pathology and Laboratory Medicine, The Robert Larner M.D. College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Biochemistry, The Robert Larner M.D. College of Medicine, University of Vermont, Burlington, VT, USA.
van Dam RM; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Vujkovic M; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.
Wang S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Welch RP; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Witte DR; Department of Public Health, Aarhus University, Aarhus, Denmark.; Danish Diabetes Academy, Odense, Denmark.
Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.
Atzmon G; Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.; Faculty of Natural Science, University of Haifa, Haifa, Israel.; Department of Genetics, Albert Einstein College of Medicine, New York, NY, USA.
Barzilai N; Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.; Department of Genetics, Albert Einstein College of Medicine, New York, NY, USA.
Blangero J; Department of Human Genetics, University of Texas Rio Grande Valley, Edinburg, TX, USA.; South Texas Diabetes and Obesity Institute, Brownsville, TX, USA.
Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Bowden DW; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.
Chan E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.
Cheng CY; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, South Korea.
Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
de Vries PS; Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Duggirala R; Department of Human Genetics, University of Texas Rio Grande Valley, Edinburg, TX, USA.; South Texas Diabetes and Obesity Institute, Brownsville, TX, USA.
Glaser B; Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Gonzalez C; Unidad de Diabetes y Riesgo Cardiovascular, Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
Gonzalez ME; Centro de Estudios en Diabetes, Mexico City, Mexico.
Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Genetics Finland, University of Helsinki, Helsinki, Finland.
Kooner JS; National Heart and Lung Institute, Cardiovascular Sciences, Imperial College London, London, UK.
Kwak SH; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicin, Kuopio University Hospital, Kuopio, Finland.
Lehman DM; Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
Nilsson P; Department of Clinical Sciences, Medicine, Lund University, Malmö, Sweden.
Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Tai ES; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore.
Tuomi T; Institute for Molecular Genetics Finland, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Tuomilehto J; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.; Center for Vascular Prevention, Danube University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), University Hospital LaPaz, Autonomous University of Madrid, Madrid, Spain.
Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Aguilar-Salinas CA; Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.
Bottinger E; Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY, USA.
Burke B; Biostatistics Center, George Washington University, Rockville, MD, USA.
Carey DJ; Geisinger Health System, Danville, PA, USA.
Chan JCN; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.
Dupuis J; National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Frossard P; Center for Non-Communicable Diseases, Karachi, Pakistan.
Heckbert SR; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Hwang MY; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea.
Kim YJ; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea.
Kirchner HL; Geisinger Health System, Danville, PA, USA.
Lee JY; Department of Business Data Convergence, Chungbuk National University, Gyeonggi-do, South Korea.
Lee J; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea.
Loos RJF; Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY, USA.; The Mindich Child Health and Development Insititute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.
Morris AD; Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK.
O'Donnell CJ; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Section of Cardiology, Department of Medicine, VA Boston Healthcare, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA.; Intramural Administration Management Branch, National Heart Lung and Blood Institute, NIH, Framingham, MA, USA.
Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK.
Pankow J; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Park KS; National Heart and Lung Institute, Cardiovascular Sciences, Imperial College London, London, UK.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan.
Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan.
Sim X; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore.
Haiman C; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Henderson BE; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Orozco L; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Tusié-Luna T; Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.; Instituto de Investigaciones Biomédicas, Departamento de Medicina Genómica y Toxicología, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Dewey FE; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Baras A; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Meitinger T; Institute of Human Genetics, Technische Universität München, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Strauch K; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Neuherberg, Germany.
Lange L; Department of Medicine, University of Colorado Denver, Aurora, CO, USA.
Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Zeitler P; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Dabelea D; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.
Abecasis G; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Bell GI; Department of Medicine, The University of Chicago, Chicago, IL, USA.; Department of Human Genetics, The University of Chicago, Chicago, IL, USA.
Cox NJ; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.
Seielstad M; Department of Laboratory Medicine & Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Blood Systems Research Institute, San Francisco, CA, USA.
Sladek R; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.
Meigs JB; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.
Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Rotter JI; Department of Pediatrics, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Altshuler D; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Burtt NP; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.
Scott LJ; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Morris AP; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK.
Florez JC; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.
Boehnke M; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
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Corporate Authors :
Broad Genomics Platform
DiscovEHR Collaboration
CHARGE
LuCamp
ProDiGY
GoT2D
ESP
SIGMA-T2D
T2D-GENES
AMP-T2D-GENES
Źródło :
Nature [Nature] 2019 Jun; Vol. 570 (7759), pp. 71-76. Date of Electronic Publication: 2019 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Whole Exome Sequencing*
Diabetes Mellitus, Type 2/*genetics
Exome/*genetics
Animals ; Case-Control Studies ; Decision Support Techniques ; Female ; Gene Frequency ; Genome-Wide Association Study ; Humans ; Male ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.
Autorzy :
Choi SH; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Weng LC; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Cardiovascular Research Center, Massachusetts General Hospital, Boston.
Roselli C; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Lin H; National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts.; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.
Haggerty CM; Department of Imaging Science and Innovation, Geisinger, Danville, Pennsylvania.
Shoemaker MB; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.
Barnard J; Departments of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Chasman DI; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Divisions of Preventive Medicine and Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Albert CM; Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Chaffin M; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Tucker NR; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Cardiovascular Research Center, Massachusetts General Hospital, Boston.
Smith JD; Departments of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio.
Gupta N; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Gabriel S; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Margolin L; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Shea MA; Cardiovascular Research Center, Massachusetts General Hospital, Boston.
Shaffer CM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.
Yoneda ZT; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.
Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston.
Smith NL; Department of Epidemiology and Cardiovascular Health Research Unit, University of Washington, Seattle.
Silverman EK; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Redline S; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Vasan RS; National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts.
Burchard EG; Department of Bioengineering, School of Pharmacy, University of California, San Francisco.
Gogarten SM; Department of Biostatistics, University of Washington, Seattle.
Laurie C; Department of Biostatistics, University of Washington, Seattle.
Blackwell TW; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor.
Abecasis G; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor.
Carey DJ; Department of Molecular and Functional Genomics, Geisinger, Danville, Pennsylvania.
Fornwalt BK; Department of Imaging Science and Innovation, Geisinger, Danville, Pennsylvania.
Smelser DT; Department of Molecular and Functional Genomics, Geisinger, Danville, Pennsylvania.
Baras A; Regeneron Genetics Center, Tarrytown, New York.
Dewey FE; Regeneron Genetics Center, Tarrytown, New York.
Jaquish CE; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Papanicolaou GJ; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Sotoodehnia N; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle.
Van Wagoner DR; Departments of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio.
Psaty BM; Department of Epidemiology and Cardiovascular Health Research Unit, University of Washington, Seattle.; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle.; Kaiser Permanente Washington Health Research Institute, Seattle, Washington.; Department of Health Services, University of Washington, Seattle.
Kathiresan S; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Darbar D; Division of Cardiology, Department of Medicine, University of Illinois, Chicago.
Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Heckbert SR; Department of Epidemiology and Cardiovascular Health Research Unit, University of Washington, Seattle.; Kaiser Permanente Washington Health Research Institute, Seattle, Washington.
Chung MK; Departments of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio.
Roden DM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.
Benjamin EJ; National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts.; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
Murray MF; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Lunetta KL; National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Lubitz SA; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Cardiovascular Research Center, Massachusetts General Hospital, Boston.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
Ellinor PT; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Cardiovascular Research Center, Massachusetts General Hospital, Boston.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
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Corporate Authors :
DiscovEHR study and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Źródło :
JAMA [JAMA] 2018 Dec 11; Vol. 320 (22), pp. 2354-2364.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Loss of Function Mutation*
Atrial Fibrillation/*genetics
Connectin/*genetics
Adult ; Age of Onset ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Heterozygote ; Humans ; Male ; Middle Aged ; Quality Control
Czasopismo naukowe
Tytuł :
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
Autorzy :
Klarin D; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Boston VA Healthcare System, Boston, MA, USA.
Damrauer SM; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Sun YV; Department of Epidemiology, Rollins School of Public Health, Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, USA.
Teslovich TM; Regeneron Genetics Center, Tarrytown, NY, USA.
Honerlaw J; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Gagnon DR; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
DuVall SL; VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Li J; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA.
Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Chaffin M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Small AM; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
Huang J; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Tang H; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Lynch JA; VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; University of Massachusetts College of Nursing and Health Sciences, Boston, MA, USA.
Ho YL; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Liu DJ; Department of Public Health Sciences, Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA.
Emdin CA; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Li AH; Regeneron Genetics Center, Tarrytown, NY, USA.
Huffman JE; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Lee JS; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA.
Natarajan P; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Chowdhury R; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Saleheen D; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Vujkovic M; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Baras A; Regeneron Genetics Center, Tarrytown, NY, USA.
Pyarajan S; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Di Angelantonio E; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Neale BM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Naheed A; Initiative for Noncommunicable Diseases, Health Systems and Population Studies Division, International Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
Khera AV; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Danesh J; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Chang KM; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Abecasis G; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Willer C; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Dewey FE; Regeneron Genetics Center, Tarrytown, NY, USA.
Carey DJ; Geisinger Health System, Danville, PA, USA.
Concato J; Department of Medicine, Yale School of Medicine, New Haven, CT, USA.; Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, CT, USA.
Gaziano JM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
O'Donnell CJ; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Tsao PS; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA.
Kathiresan S; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Rader DJ; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wilson PWF; Atlanta VA Medical Center, Decatur, GA, USA.; Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.
Assimes TL; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. .; VA Palo Alto Health Care System, Palo Alto, CA, USA. .
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Corporate Authors :
Global Lipids Genetics Consortium
Myocardial Infarction Genetics (MIGen) Consortium
Geisinger-Regeneron DiscovEHR Collaboration
VA Million Veteran Program
Źródło :
Nature genetics [Nat Genet] 2018 Nov; Vol. 50 (11), pp. 1514-1523. Date of Electronic Publication: 2018 Oct 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Ethnic Groups/*genetics
Lipid Metabolism/*genetics
Lipids/*blood
Veterans/*statistics & numerical data
African Continental Ancestry Group/genetics ; African Continental Ancestry Group/statistics & numerical data ; Aged ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/ethnology ; Cardiovascular Diseases/genetics ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/ethnology ; Diabetes Mellitus, Type 2/genetics ; Ethnic Groups/statistics & numerical data ; European Continental Ancestry Group/genetics ; European Continental Ancestry Group/statistics & numerical data ; Female ; Genome-Wide Association Study ; Genotype ; Hispanic Americans/genetics ; Hispanic Americans/statistics & numerical data ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Author Correction: Rare variants in drug target genes contributing to complex diseases, phenome-wide.
Autorzy :
Verma SS; Perelman School of Medicine, Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Josyula N; Biomedical and Translational Informatics Institute, Geisinger, Danville, PA, 17221, USA.
Verma A; Perelman School of Medicine, Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zhang X; Perelman School of Medicine, Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Veturi Y; Perelman School of Medicine, Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Dewey FE; Regeneron Genetics Center, Tarrytown, NY, 10591, USA.
Hartzel DN; Phenomic Analytics and Clinical Data Core, Geisinger, Danville, PA, USA.
Lavage DR; Phenomic Analytics and Clinical Data Core, Geisinger, Danville, PA, USA.
Leader J; Biomedical and Translational Informatics Institute, Geisinger, Danville, PA, 17221, USA.; Phenomic Analytics and Clinical Data Core, Geisinger, Danville, PA, USA.
Ritchie MD; Perelman School of Medicine, Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Pendergrass SA; Biomedical and Translational Informatics Institute, Geisinger, Danville, PA, 17221, USA. .
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Źródło :
Scientific reports [Sci Rep] 2018 Oct 23; Vol. 8 (1), pp. 15911. Date of Electronic Publication: 2018 Oct 23.
Typ publikacji :
Published Erratum
Tytuł :
Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension.
Autorzy :
Bohnen MS; Department of Pharmacology, College of Physicians and Surgeons (M.S.B., K.J.S., R.S.K.), Columbia University, New York, NY.
Ma L; Department of Pediatrics, College of Physicians and Surgeons (L.M., N.Z., U.K., E.B.R., W.K.C.), Columbia University, New York, NY.
Zhu N; Department of Pediatrics, College of Physicians and Surgeons (L.M., N.Z., U.K., E.B.R., W.K.C.), Columbia University, New York, NY.; Department of Systems Biology (N.Z., H.Q., Y.S.), Columbia University, New York, NY.
Qi H; Department of Applied Physics and Applied Mathematics (H.Q., Y.S.), Columbia University, New York, NY.; Department of Systems Biology (N.Z., H.Q., Y.S.), Columbia University, New York, NY.
McClenaghan C; Department of Cell Biology and Physiology (C.M., C.G.N.) and Center for the Investigation of Membrane Excitability Diseases (C.M., C.G.N.), Washington University School of Medicine, Washington University in St. Louis, MO.
Gonzaga-Jauregui C; Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc, Tarrytown, NY (C.G.-J., F.E.D., J.D.O., J.G.R., A.R.S., A.B.).
Dewey FE; Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc, Tarrytown, NY (C.G.-J., F.E.D., J.D.O., J.G.R., A.R.S., A.B.).
Overton JD; Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc, Tarrytown, NY (C.G.-J., F.E.D., J.D.O., J.G.R., A.R.S., A.B.).
Reid JG; Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc, Tarrytown, NY (C.G.-J., F.E.D., J.D.O., J.G.R., A.R.S., A.B.).
Shuldiner AR; Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc, Tarrytown, NY (C.G.-J., F.E.D., J.D.O., J.G.R., A.R.S., A.B.).
Baras A; Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc, Tarrytown, NY (C.G.-J., F.E.D., J.D.O., J.G.R., A.R.S., A.B.).
Sampson KJ; Department of Pharmacology, College of Physicians and Surgeons (M.S.B., K.J.S., R.S.K.), Columbia University, New York, NY.
Bleda M; Department of Medicine (M.B., C.H., M.H., J.M.M., M.T., C.M.T., K.Y., S.G., N.W.M.), University of Cambridge, United Kingdom.
Hadinnapola C; Department of Medicine (M.B., C.H., M.H., J.M.M., M.T., C.M.T., K.Y., S.G., N.W.M.), University of Cambridge, United Kingdom.
Haimel M; Department of Medicine (M.B., C.H., M.H., J.M.M., M.T., C.M.T., K.Y., S.G., N.W.M.), University of Cambridge, United Kingdom.
Bogaard HJ; VU University Medical Center, Amsterdam, the Netherlands (H.J.B., A.C.H., A.V.N.).
Church C; Golden Jubilee National Hospital, Glasgow, Scotland (C.C., A.J.P.).
Coghlan G; Royal Free Hospital, London, England (G.C.).
Corris PA; Newcastle University (P.A.C.) and Newcastle upon Tyne Hospitals National Health Service Foundation Trust (P.A.C.), United Kingdom.
Eyries M; Dépat de Génétique, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (M.E., F.S.) and UMR_S 1166-ICAN, INSERM (Institut National de la Santé et de la Recherche Médicale) (M.E., F.S.), UPMC (Pierre and Marie Curie University) Sorbonne Universités, France.
Gibbs JSR; National Heart and Lung Institute, Imperial College London, United Kingdom (J.S.R.G., S.J.W.).
Girerd B; AP-HP (Assistance Publique - Hôpitaux de Paris), Centre de référence de l'hypertension pulmonaire sévère, INSERM UMR_S 999, Hôpital Bicêtre, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France (B.G., M.H., C.G., D.M.).
Houweling AC; VU University Medical Center, Amsterdam, the Netherlands (H.J.B., A.C.H., A.V.N.).
Humbert M; AP-HP (Assistance Publique - Hôpitaux de Paris), Centre de référence de l'hypertension pulmonaire sévère, INSERM UMR_S 999, Hôpital Bicêtre, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France (B.G., M.H., C.G., D.M.).
Guignabert C; AP-HP (Assistance Publique - Hôpitaux de Paris), Centre de référence de l'hypertension pulmonaire sévère, INSERM UMR_S 999, Hôpital Bicêtre, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France (B.G., M.H., C.G., D.M.).
Kiely DG; Sheffield Clinical Research Facility, Royal Hallamshire, Sheffield, United Kingdom (D.G.K.).
Lawrie A; Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom (A.L.).
MacKenzie Ross RV; Royal United Bath Hospitals, Bath, United Kingdom (R.V.M.R., J.S.).
Martin JM; Department of Medicine (M.B., C.H., M.H., J.M.M., M.T., C.M.T., K.Y., S.G., N.W.M.), University of Cambridge, United Kingdom.
Montani D; AP-HP (Assistance Publique - Hôpitaux de Paris), Centre de référence de l'hypertension pulmonaire sévère, INSERM UMR_S 999, Hôpital Bicêtre, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France (B.G., M.H., C.G., D.M.).
Peacock AJ; Golden Jubilee National Hospital, Glasgow, Scotland (C.C., A.J.P.).
Pepke-Zaba J; Papworth Hospital, Cambridge, United Kingdom (J.P.-Z., M.T.).
Soubrier F; Dépat de Génétique, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (M.E., F.S.) and UMR_S 1166-ICAN, INSERM (Institut National de la Santé et de la Recherche Médicale) (M.E., F.S.), UPMC (Pierre and Marie Curie University) Sorbonne Universités, France.
Suntharalingam J; Royal United Bath Hospitals, Bath, United Kingdom (R.V.M.R., J.S.).
Toshner M; Department of Medicine (M.B., C.H., M.H., J.M.M., M.T., C.M.T., K.Y., S.G., N.W.M.), University of Cambridge, United Kingdom.; Papworth Hospital, Cambridge, United Kingdom (J.P.-Z., M.T.).
Treacy CM; Department of Medicine (M.B., C.H., M.H., J.M.M., M.T., C.M.T., K.Y., S.G., N.W.M.), University of Cambridge, United Kingdom.
Trembath RC; Division of Genetics and Molecular Medicine, King's College London, London, England (R.C.T.).
Vonk Noordegraaf A; VU University Medical Center, Amsterdam, the Netherlands (H.J.B., A.C.H., A.V.N.).
Wharton J; Department of Medicine, Imperial College London, Hammersmith Campus, London, United Kingdom (J.W., M.R.W.).
Wilkins MR; Department of Medicine, Imperial College London, Hammersmith Campus, London, United Kingdom (J.W., M.R.W.).
Wort SJ; National Heart and Lung Institute, Imperial College London, United Kingdom (J.S.R.G., S.J.W.).; Royal Brompton Hospital, London, United Kingdom (S.J.W.).
Yates K; Department of Medicine (M.B., C.H., M.H., J.M.M., M.T., C.M.T., K.Y., S.G., N.W.M.), University of Cambridge, United Kingdom.
Gräf S; Department of Medicine (M.B., C.H., M.H., J.M.M., M.T., C.M.T., K.Y., S.G., N.W.M.), University of Cambridge, United Kingdom.; Department of Hematology (S.G.), Addenbrookes Hospital, University of Cambridge, United Kingdom.
Morrell NW; Department of Medicine (M.B., C.H., M.H., J.M.M., M.T., C.M.T., K.Y., S.G., N.W.M.), University of Cambridge, United Kingdom.
Krishnan U; Department of Pediatrics, College of Physicians and Surgeons (L.M., N.Z., U.K., E.B.R., W.K.C.), Columbia University, New York, NY.
Rosenzweig EB; Department of Pediatrics, College of Physicians and Surgeons (L.M., N.Z., U.K., E.B.R., W.K.C.), Columbia University, New York, NY.
Shen Y; Department of Applied Physics and Applied Mathematics (H.Q., Y.S.), Columbia University, New York, NY.; Department of Systems Biology (N.Z., H.Q., Y.S.), Columbia University, New York, NY.
Nichols CG; Department of Cell Biology and Physiology (C.M., C.G.N.) and Center for the Investigation of Membrane Excitability Diseases (C.M., C.G.N.), Washington University School of Medicine, Washington University in St. Louis, MO.
Kass RS; Department of Pharmacology, College of Physicians and Surgeons (M.S.B., K.J.S., R.S.K.), Columbia University, New York, NY.
Chung WK; Department of Pediatrics, College of Physicians and Surgeons (L.M., N.Z., U.K., E.B.R., W.K.C.), Columbia University, New York, NY.
Pokaż więcej
Źródło :
Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2018 Oct; Vol. 11 (10), pp. e002087.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Exome*
Mutation, Missense*
Familial Primary Pulmonary Hypertension/*genetics
Sulfonylurea Receptors/*genetics
Adult ; Amino Acid Substitution ; Child ; DNA Mutational Analysis ; Familial Primary Pulmonary Hypertension/drug therapy ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
Exome Sequencing-Based Screening for BRCA1/2 Expected Pathogenic Variants Among Adult Biobank Participants.
Autorzy :
Manickam K; Molecular and Human Genetics Department, Nationwide Children's Hospital, Columbus, Ohio.; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Buchanan AH; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Schwartz MLB; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Hallquist MLG; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Williams JL; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Rahm AK; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Rocha H; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Savatt JM; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Evans AE; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Butry LM; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Lazzeri AL; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Lindbuchler DM; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Flansburg CN; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Leeming R; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Vogel VG; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Lebo MS; Laboratory for Molecular Medicine, Partners HealthCare, Cambridge, Massachusetts.
Mason-Suares HM; Laboratory for Molecular Medicine, Partners HealthCare, Cambridge, Massachusetts.
Hoskinson DC; Laboratory for Molecular Medicine, Partners HealthCare, Cambridge, Massachusetts.
Abul-Husn NS; Regeneron Genetics Center, Tarrytown, New York.
Dewey FE; Regeneron Genetics Center, Tarrytown, New York.
Overton JD; Regeneron Genetics Center, Tarrytown, New York.
Reid JG; Regeneron Genetics Center, Tarrytown, New York.
Baras A; Regeneron Genetics Center, Tarrytown, New York.
Willard HF; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
McCormick CZ; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Krishnamurthy SB; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Hartzel DN; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Kost KA; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Lavage DR; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Sturm AC; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Frisbie LR; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Person TN; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Metpally RP; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Giovanni MA; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Lowry LE; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Leader JB; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Ritchie MD; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.; Center for Translational Bioinformatics, University of Pennsylvania, Philadelphia.
Carey DJ; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Justice AE; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Kirchner HL; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Faucett WA; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Williams MS; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Ledbetter DH; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.
Murray MF; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania.; Department of Genetics, Yale School of Medicine, New Haven, Connecticut.
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Źródło :
JAMA network open [JAMA Netw Open] 2018 Sep 07; Vol. 1 (5), pp. e182140. Date of Electronic Publication: 2018 Sep 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
BRCA1 Protein/*analysis
BRCA2 Protein/*analysis
Whole Exome Sequencing/*methods
Adult ; Aged ; Aged, 80 and over ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Biological Specimen Banks/statistics & numerical data ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/blood ; Cross-Sectional Studies ; Early Detection of Cancer/methods ; Exome/genetics ; Female ; Humans ; Male ; Middle Aged ; Pennsylvania ; Virulence/genetics ; Whole Exome Sequencing/statistics & numerical data
Czasopismo naukowe
Tytuł :
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
Autorzy :
Nielsen JB; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Thorolfsdottir RB; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Fritsche LG; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Zhou W; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Skov MW; Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Graham SE; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Herron TJ; Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA.
McCarthy S; Regeneron Genetics Center, Tarrytown, NY, USA.
Schmidt EM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Sveinbjornsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Surakka I; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Mathis MR; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Yamazaki M; Medical Device Development and Regulation Research Center, The University of Tokyo, Tokyo, Japan.
Crawford RD; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Gabrielsen ME; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
Skogholt AH; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
Holmen OL; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Cardiology, St. Olav's University Hospital, Trondheim, Norway.
Lin M; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Wolford BN; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Dey R; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Dalen H; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Cardiology, St. Olav's University Hospital, Trondheim University Hospital, Trondheim, Norway.
Sulem P; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Chung JH; Regeneron Genetics Center, Tarrytown, NY, USA.
Backman JD; Regeneron Genetics Center, Tarrytown, NY, USA.
Arnar DO; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali - National University Hospital, Reykjavik, Iceland.
Thorsteinsdottir U; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Baras A; Regeneron Genetics Center, Tarrytown, NY, USA.
O'Dushlaine C; Regeneron Genetics Center, Tarrytown, NY, USA.
Holst AG; Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Wen X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Hornsby W; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Dewey FE; Regeneron Genetics Center, Tarrytown, NY, USA.
Boehnke M; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Kheterpal S; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Mukherjee B; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Lee S; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Kang HM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Holm H; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Kitzman J; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Shavit JA; Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA.
Jalife J; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA.; Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Brummett CM; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Teslovich TM; Regeneron Genetics Center, Tarrytown, NY, USA.
Carey DJ; Geisinger Health System, Danville, PA, USA.
Gudbjartsson DF; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
Stefansson K; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Abecasis GR; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway. .; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. .
Hveem K; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway. .; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway. .; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway. .
Willer CJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA. .; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. .; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. .
Pokaż więcej
Źródło :
Nature genetics [Nat Genet] 2018 Sep; Vol. 50 (9), pp. 1234-1239. Date of Electronic Publication: 2018 Jul 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Atrial Fibrillation/*genetics
Mutation/*genetics
Biological Specimen Banks ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study/methods ; Genomics/methods ; Heart Defects, Congenital/genetics ; Humans ; Risk
Czasopismo naukowe

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