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Tytuł :
Consequences of inaccurate hepatitis C virus genotyping on the costs of prescription of direct antiviral agents in an Italian district
Autorzy :
Polilli E
Cento V
Restelli U
Ceccherini-Silberstein F
Aragri M
Di Maio VC
Sciacca A
Santoleri F
Fazii P
Costantini A
Perno CF
Parruti G
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Temat :
HCV
HCV sequence analysis
HCV genotype
Direct Acting Antiviral
Treatment costs
Medicine (General)
R5-920
Therapeutics. Pharmacology
RM1-950
Źródło :
ClinicoEconomics and Outcomes Research, Vol Volume 8, Pp 467-473 (2016)
Opis pliku :
electronic resource
Relacje :
https://www.dovepress.com/consequences-of-inaccurate-hepatitis-c-virus-genotyping-on-the-costs-o-peer-reviewed-article-CEOR; https://doaj.org/toc/1178-6981
Dostęp URL :
https://doaj.org/article/d40f7262b55448d28bf73be4367dce29
Czasopismo naukowe
Tytuł :
Resistance analysis and treatment outcomes in hepatitis C virus genotype 3-infected patients within the Italian network VIRONET-C.
Autorzy :
Di Maio VC; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Barbaliscia S; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Teti E; Infectious Diseases, University Hospital of Rome Tor Vergata, Rome, Italy.
Fiorentino G; Infectious Diseases, Sant'Andrea Hospital - 'La Sapienza', Rome, Italy.
Milana M; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Paolucci S; Molecular Virology Unit, Microbiology and Virology Department, IRCCS Policlinic Foundation San Matteo, Pavia, Italy.
Pollicino T; Department of Internal Medicine, University Hospital of Messina, Messina, Italy.
Morsica G; Division of Infectious Diseases, IRCCS, Ospedale San Raffaele, Milan, Italy.
Starace M; Laboratory for the identification of prognostic factors of response to the treatment against infectious diseases, University of Campania 'L. Vanvitelli', Napoli, Italy.
Bruzzone B; Hygiene Unit, IRCCS AOU San Martino-IST, Genoa, Italy.
Gennari W; Microbiology Unit, University Hospital of Modena, Modena, Italy.
Micheli V; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy.
Yu La Rosa K; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Foroghi L; Infectious Diseases, University Hospital of Rome Tor Vergata, Rome, Italy.
Calvaruso V; Gastroenterology, 'P. Giaccone' University Hospital, Palermo, Italy.
Lenci I; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Polilli E; Infectious Disease Unit, Pescara General Hospital, Pescara, Italy.
Babudieri S; Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Aghemo A; Division of Internal Medicine and Hepatology, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.
Raimondo G; Department of Internal Medicine, University Hospital of Messina, Messina, Italy.
Sarmati L; Infectious Diseases, University Hospital of Rome Tor Vergata, Rome, Italy.
Coppola N; Laboratory for the identification of prognostic factors of response to the treatment against infectious diseases, University of Campania 'L. Vanvitelli', Napoli, Italy.; Department of Mental Health and Public Medicine, Infectious Diseases Unit, University of Campania 'L. Vanvitelli', Naples, Italy.
Pasquazzi C; Infectious Diseases, Sant'Andrea Hospital - 'La Sapienza', Rome, Italy.
Baldanti F; Molecular Virology Unit, Microbiology and Virology Department, IRCCS Policlinic Foundation San Matteo, Pavia, Italy.
Parruti G; Infectious Disease Unit, Pescara General Hospital, Pescara, Italy.
Perno CF; IRCCS Children Hospital Bambino Gesù, Rome, Italy.
Angelico M; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Craxì A; Gastroenterology, 'P. Giaccone' University Hospital, Palermo, Italy.
Andreoni M; Infectious Diseases, University Hospital of Rome Tor Vergata, Rome, Italy.
Ceccherini-Silberstein F; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
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Corporate Authors :
HCV Virology Italian Resistance Network Group (Vironet C)
Źródło :
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2021 Jan 26. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control.
Autorzy :
Salpini R; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Alkhatib M; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Costa G; Dipartimento di Scienze della Salute, Università 'Magna Græcia', Catanzaro, Italy.; Net4Science srl, Università 'Magna Græcia', Catanzaro, Italy.
Piermatteo L; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Ambrosio FA; Dipartimento di Scienze della Salute, Università 'Magna Græcia', Catanzaro, Italy.
Di Maio VC; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Scutari R; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Duca L; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Berno G; Laboratory of Virology, National Institute for Infectious Diseases 'Lazzaro Spallanzani'-IRCCS, Rome, Italy.
Fabeni L; Laboratory of Virology, National Institute for Infectious Diseases 'Lazzaro Spallanzani'-IRCCS, Rome, Italy.
Alcaro S; Dipartimento di Scienze della Salute, Università 'Magna Græcia', Catanzaro, Italy.; Net4Science srl, Università 'Magna Græcia', Catanzaro, Italy.
Ceccherini-Silberstein F; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Artese A; Dipartimento di Scienze della Salute, Università 'Magna Græcia', Catanzaro, Italy.; Net4Science srl, Università 'Magna Græcia', Catanzaro, Italy.
Svicher V; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.
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Źródło :
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2021 Jan 19; Vol. 76 (2), pp. 396-412.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptation, Biological/*genetics
Antiviral Agents/*metabolism
COVID-19/*immunology
Coronavirus 3C Proteases/*genetics
Coronavirus Protease Inhibitors/*metabolism
Coronavirus RNA-Dependent RNA Polymerase/*genetics
SARS-CoV-2/*genetics
Americas ; Amino Acid Sequence ; Antigens, Viral/blood ; Antiviral Agents/therapeutic use ; Asia ; COVID-19/drug therapy ; COVID-19/epidemiology ; Computer Simulation ; Coronavirus 3C Proteases/metabolism ; Coronavirus Protease Inhibitors/therapeutic use ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Europe ; Evolution, Molecular ; Humans ; Molecular Docking Simulation ; Multigene Family ; Mutation/genetics ; Mutation Rate ; Oceania ; Protein Binding ; SARS-CoV-2/enzymology ; Topography, Medical
Czasopismo naukowe
Tytuł :
Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses.
Autorzy :
Artese A; Dipartimento di Scienze della Salute, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy; Net4Science Academic Spin-Off, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy.
Svicher V; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Costa G; Dipartimento di Scienze della Salute, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy; Net4Science Academic Spin-Off, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy.
Salpini R; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Di Maio VC; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Alkhatib M; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Ambrosio FA; Dipartimento di Scienze della Salute, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy.
Santoro MM; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Assaraf YG; The Fred Wyszkowski Cancer Research Lab, Faculty of Biology, Technion, Israel Institute of Technology, Haifa, Israel.
Alcaro S; Dipartimento di Scienze della Salute, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy; Net4Science Academic Spin-Off, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy.
Ceccherini-Silberstein F; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address: .
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Źródło :
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy [Drug Resist Updat] 2020 Dec; Vol. 53, pp. 100721. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents/*administration & dosage
Coronavirus Infections/*drug therapy
Drug Delivery Systems/*methods
SARS-CoV-2/*drug effects
Amino Acid Sequence ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; COVID-19/drug therapy ; COVID-19/metabolism ; Coronavirus Infections/metabolism ; Drug Delivery Systems/trends ; Humans ; Protease Inhibitors/administration & dosage ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/chemistry ; Reverse Transcriptase Inhibitors/metabolism ; SARS-CoV-2/metabolism
Czasopismo naukowe
Tytuł :
Failure on voxilaprevir, velpatasvir, sofosbuvir and efficacy of rescue therapy.
Autorzy :
Dietz J; Department of Internal Medicine 1, University Hospital, Goethe University, Frankfurt, Germany; German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany.
Di Maio VC; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
de Salazar A; Department of Clinical Microbiology, Hospital Universitario San Cecilio, Instituto de Investigación Ibs, Granada, Spain.
Merino D; Infectious Diseases Unit, Hospital Juan Ramón Jiménez, Spain.
Vermehren J; Department of Internal Medicine 1, University Hospital, Goethe University, Frankfurt, Germany; German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany.
Paolucci S; Molecular Virology Unit, Microbiology and Virology Department, IRCCS Policlinic Foundation San Matteo, Pavia, Italy.
Kremer AE; Department of Medicine I, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Lara M; Hospital Nuestra Sra de Candelaria, Tenerife, Spain.
Pardo MR; Hospital Universitario Puerta del Mar, Cádiz, Spain.
Zoller H; Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Innsbruck, Austria.
Degasperi E; Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico - Division of Gastroenterology and Hepatology - CRC 'A. M. and A. Migliavacca' Center for Liver Disease, Milan, Italy.
Peiffer KH; Department of Internal Medicine 1, University Hospital, Goethe University, Frankfurt, Germany; German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany.
Sighinolfi L; University Hospital of Ferrara, Ferrara, Italy.
Téllez F; Infectious Diseases Unit, University Hospital of Puerto Real, Cádiz, Spain.
Graf C; Department of Internal Medicine 1, University Hospital, Goethe University, Frankfurt, Germany; German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany.
Ghisetti V; Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, ASL Città di Torino, Turin, Italy.
Schreiber J; Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Fernández-Fuertes E; Infectious Diseases Unit, Hospital de Poniente, El Ejido, Almería, Spain.
Boglione L; Department of Translational Medicine (DiMET), University of Piemonte Orientale, Novara, Italy.
Muñoz-Medina L; Department of Infectious Disease, Hospital Universitario San Cecilio, Granada, Spain.
Stauber R; Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Gennari W; Microbiology Unit, University Hospital of Modena, Modena, Italy.
Figueruela B; Hospital Universitario Virgen de Valme, Sevilla, Spain.
Santos J; Infectious Diseases Unit, Hospital Universitario Virgen de la Victoria, Instituto de Investigación, IBIMA, Málaga, Spain.
Lampertico P; Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico - Division of Gastroenterology and Hepatology - CRC 'A. M. and A. Migliavacca' Center for Liver Disease, Milan, Italy.
Zeuzem S; Department of Internal Medicine 1, University Hospital, Goethe University, Frankfurt, Germany; German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany.
Ceccherini-Silberstein F; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
García F; Department of Clinical Microbiology, Hospital Universitario San Cecilio, Instituto de Investigación Ibs, Granada, Spain.
Sarrazin C; Department of Internal Medicine 1, University Hospital, Goethe University, Frankfurt, Germany; German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany; Medizinische Klinik 2, St. Josefs-Hospital, Wiesbaden, Germany. Electronic address: .
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Corporate Authors :
HCV Virology Italian Resistance Network (VIRONET-C) collaborators
Spanish GEHEP-004 Collaborators
Members of the German HCV resistance study group
Źródło :
Journal of hepatology [J Hepatol] 2020 Nov 19. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Prevalence of resistance-associated substitutions and retreatment of patients failing a glecaprevir/pibrentasvir regimen.
Autorzy :
de Salazar A; Clinical Microbiology Unit, University Hospital San Cecilio, Instituto de Investigacion Ibs.Granada. Granada, Spain.
Dietz J; Department of Internal Medicine 1, University Hospital Frankfurt, Frankfurt, Germany; German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany.
di Maio VC; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Vermehren J; Department of Internal Medicine 1, University Hospital Frankfurt, Frankfurt, Germany; German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany.
Paolucci S; Molecular Virology Unit, Microbiology and Virology Department, IRCCS Policlinic Foundation San Matteo, Pavia, Italy.
Müllhaupt B; Swiss Hepato-Pancreato-Biliary Center and Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
Coppola N; Department of Mental Health and Public Medicine, Infectious Diseases Unit, University of Campania 'L. Vanvitelli', Naples, Italy.
Cabezas J; Department of Hepatology, Marqués de Valdecilla University Hospital, Santander, Spain.
Stauber RE; Department of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria.
Puoti M; Infectious Diseases, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Arenas Ruiz Tapiador JI; Infectious Diseases Unit, University Hospital Donostia, San Sebastián, Spain.
Graf C; Department of Internal Medicine 1, University Hospital Frankfurt, Frankfurt, Germany; German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany.
Aragri M; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Jimenez M; Hepatology Unit, Hospital Regional de Málaga, Málaga, Spain.
Callegaro A; Microbiology and Virology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
Pascasio Acevedo JM; Hepatology Unit, University Hospital Virgen del Rocío, Seville, Spain.
Macias Rodriguez MA; Department of Digestive Diseases, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Rosales Zabal JM; Gastrointestinal Unit, Hospital Costa del Sol, Marbella, Málaga, Spain.
Micheli V; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy.
Garcia Del Toro M; Infectious Diseases Unit, Hospital General de Valencia, Valencia, Spain.
Téllez F; Infectious Diseases Unit, Hospital Puerto Real, Puerto Real, Cádiz, Spain.
García F; Clinical Microbiology Unit, University Hospital San Cecilio, Instituto de Investigacion Ibs.Granada. Granada, Spain.
Sarrazin C; Department of Internal Medicine 1, University Hospital Frankfurt, Frankfurt, Germany; German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany.; Medizinische Klinik 2, St. Josefs Hospital, Wiesbaden, Germany.
Ceccherini-Silberstein F; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
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Corporate Authors :
GEHEP-004 cohort, the European HCV Resistance Study Group and the HCV Virology Italian Resistance Network (VIRONET C)
Źródło :
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2020 Nov 01; Vol. 75 (11), pp. 3349-3358.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Successful ongoing retreatment with glecaprevir/pibrentasvir + sofosbuvir + ribavirin in a patient with HCV genotype 3 who failed glecaprevir/pibrentasvir with both NS3 and NS5A resistance.
Autorzy :
Aragri M; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Milana M; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Di Maio VC; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Lenci I; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Carioti L; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Perno CF; Department of Oncology and Oncohematology, University of Milan, Milan, Italy.
Svicher V; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Angelico M; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Ceccherini-Silberstein F; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address: .
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Źródło :
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2020 Sep; Vol. 26 (9), pp. 1266-1268. Date of Electronic Publication: 2020 Mar 30.
Typ publikacji :
Letter
Opinia redakcyjna
Tytuł :
NS5A Gene Analysis by Next Generation Sequencing in HCV Nosocomial Transmission Clusters of HCV Genotype 1b Infected Patients.
Autorzy :
Bellocchi MC; Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Aragri M; Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Carioti L; Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Fabeni L; Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Pipitone RM; Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE) Department, University of Palermo, 90127 Palermo, Italy.
Brancaccio G; Infectious Diseases, Department of Mental and Physical Health and Preventive Medicine, Campania University 'Luigi Vanvitelli', 80138 Naples, Italy.; Department of Molecular Medicine, University of Padua, 35121 Padua, Italy.
Sorbo MC; Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Barbaliscia S; Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Di Maio VC; Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Bronte F; Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE) Department, University of Palermo, 90127 Palermo, Italy.
Grimaudo S; Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE) Department, University of Palermo, 90127 Palermo, Italy.
Mazzucco W; Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE) Department, University of Palermo, 90127 Palermo, Italy.
Frigeri F; Hematology Division, 'San Sebastiano' Hospital, 81100 Caserta, Italy.
Cantone M; Infectious Diseases, Department of Mental and Physical Health and Preventive Medicine, Campania University 'Luigi Vanvitelli', 80138 Naples, Italy.
Pinto A; Hematology Department, National Cancer Institute 'Fondazione Pascale', IRCCS, 80131 Naples, Italy.
Perno CF; Department of Microbiology and Clinic Microbiology, University of Milan, 20162 Milan, Italy.
Craxì A; Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE) Department, University of Palermo, 90127 Palermo, Italy.
Gaeta GB; Infectious Diseases, Department of Mental and Physical Health and Preventive Medicine, Campania University 'Luigi Vanvitelli', 80138 Naples, Italy.
Di Marco V; Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE) Department, University of Palermo, 90127 Palermo, Italy.
Ceccherini-Silberstein F; Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy. .
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Źródło :
Cells [Cells] 2019 Jul 02; Vol. 8 (7). Date of Electronic Publication: 2019 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cross Infection/*virology
Hepacivirus/*genetics
Hepatitis C/*virology
Viral Nonstructural Proteins/*genetics
beta-Thalassemia/*therapy
Acute Disease ; Adult ; Amino Acid Substitution ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Blood Transfusion ; Chronic Disease ; Cross Infection/drug therapy ; Cross Infection/transmission ; Drug Resistance, Viral/genetics ; Female ; Genotype ; Hepacivirus/pathogenicity ; Hepatitis C/drug therapy ; Hepatitis C/transmission ; High-Throughput Nucleotide Sequencing ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Interferons/genetics ; Interferons/immunology ; Male ; Middle Aged ; Phylogeny ; Polymorphism, Single Nucleotide ; beta-Thalassemia/genetics ; beta-Thalassemia/immunology
Czasopismo naukowe
Tytuł :
Viral resistance in HCV infection.
Autorzy :
Ceccherini-Silberstein F; Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Roma, Italy. Electronic address: .
Cento V; Residency Program in Microbiology and Virology, Università degli Studi di Milano, Via Festa del Perdono, 7, 20122 Milan, Italy.
Di Maio VC; Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Roma, Italy.
Perno CF; Department of Oncology and Oncohematology, Università degli Studi di Milano, Via Festa del Perdono, 7, 20122 Milan, Italy.
Craxì A; Gastroenterology, 'P. Giaccone' University Hospital of Palermo, Piazza delle Cliniche, 2, 90127 Palermo, Italy.
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Źródło :
Current opinion in virology [Curr Opin Virol] 2018 Oct; Vol. 32, pp. 115-127. Date of Electronic Publication: 2018 Nov 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Resistance, Multiple, Viral*
Antiviral Agents/*pharmacology
Hepacivirus/*drug effects
Hepatitis C, Chronic/*drug therapy
Antiviral Agents/therapeutic use ; Drug Therapy, Combination ; Genetic Variation ; Genotype ; Hepacivirus/genetics ; Humans ; Interferons/therapeutic use ; Ribavirin/therapeutic use ; Treatment Failure
Czasopismo naukowe
Tytuł :
Corrigendum to "Hepatitis C virus drug resistance associated substitutions and their clinical relevance: Update 2018" [Drug Resist. Updates 37 (March) (2018) 17-39].
Autorzy :
Sorbo MC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Cento V; Residency Program in Microbiology and Virology, Università degli Studi di Milano, Milan, Italy. Electronic address: .
Di Maio VC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Howe AYM; Centre for Excellence in HIV/AIDS, St Paul's Hospital, Vancouver, BC, Canada.
Garcia F; Clinical Microbiology Service, Hospital Universitario San Cecilio, Granada, Spain.
Perno CF; Department of Oncology and Oncohematology, Università degli Studi di Milano, Milan, Italy.
Ceccherini-Silberstein F; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
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Źródło :
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy [Drug Resist Updat] 2018 Sep; Vol. 40, pp. 40-41. Date of Electronic Publication: 2018 Apr 19.
Typ publikacji :
Journal Article; Published Erratum
Czasopismo naukowe
Tytuł :
Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1-4 in Italy.
Autorzy :
Bertoli A; Department Experimental Medicine and Surgery, University of Rome 'Tor Vergata', 00133, Rome, Italy.
Sorbo MC; Department Experimental Medicine and Surgery, University of Rome 'Tor Vergata', 00133, Rome, Italy.
Aragri M; Department Experimental Medicine and Surgery, University of Rome 'Tor Vergata', 00133, Rome, Italy.
Lenci I; Hepatology Unit, University Hospital of Rome 'Tor Vergata', 00133, Rome, Italy.
Teti E; Infectious Diseases Unit, University Hospital of Rome 'Tor Vergata', 00133, Rome, Italy.
Polilli E; Infectious Diseases Unit, Pescara General Hospital, 65124, Pescara, Italy.
Di Maio VC; Department Experimental Medicine and Surgery, University of Rome 'Tor Vergata', 00133, Rome, Italy.
Gianserra L; Infectious Diseases Unit, Sant'Andrea Hospital - 'Sapienza' University, 00189, Rome, Italy.
Biliotti E; Tropical Diseases, Umberto I Hospital -'Sapienza' University, 00161, Rome, Italy.
Masetti C; Hepatology Unit, University Hospital of Rome 'Tor Vergata', 00133, Rome, Italy.
Magni CF; 1st Division of Infectious Diseases, ASST Fatebenefratelli Sacco, 20157, Milan, Italy.
Babudieri S; Clinical and Experimental Medicine, University of Sassari, 07100, Sassari, Italy.
Nicolini LA; Infectious Diseases Unit, IRCCS AOU San Martino - IST, 16132, Genoa, Italy.
Milana M; Hepatology Unit, University Hospital of Rome 'Tor Vergata', 00133, Rome, Italy.
Cacciatore P; Infectious Diseases Unit, Pescara General Hospital, 65124, Pescara, Italy.
Sarmati L; Infectious Diseases Unit, University Hospital of Rome 'Tor Vergata', 00133, Rome, Italy.
Pellicelli A; Hepatology Unit, San Camillo Forlanini Hospital, 00151, Rome, Italy.
Paolucci S; Molecular Virology, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.
Craxì A; Gastroenterology, 'P. Giaccone' University Hospital, 90127, Palermo, Italy.
Morisco F; Gastroenterology, 'Federico II' University, 80131, Naples, Italy.
Palitti VP; Hepatology Unit, Pescara General Hospital, 65124, Pescara, Italy.
Siciliano M; Gastroenterology, Catholic University of Rome, 00168, Rome, Italy.
Coppola N; Infectious Diseases Unit, 'L. Vanvitelli' University of Campania, 80138, Naples, Italy.
Iapadre N; Infectious Diseases Unit, S. Salvatore Hospital, 67100, L'Aquila, Italy.
Puoti M; Infectious Diseases Unit, Niguarda Ca' Granda Hospital, 20162, Milan, Italy.
Rizzardini G; 1st Division of Infectious Diseases, ASST Fatebenefratelli Sacco, 20157, Milan, Italy.
Taliani G; Tropical Diseases, Umberto I Hospital -'Sapienza' University, 00161, Rome, Italy.
Pasquazzi C; Infectious Diseases Unit, Sant'Andrea Hospital - 'Sapienza' University, 00189, Rome, Italy.
Andreoni M; Infectious Diseases Unit, University Hospital of Rome 'Tor Vergata', 00133, Rome, Italy.
Parruti G; Infectious Diseases Unit, Pescara General Hospital, 65124, Pescara, Italy.
Angelico M; Hepatology Unit, University Hospital of Rome 'Tor Vergata', 00133, Rome, Italy.
Perno CF; Haematology and Oncohematology, University of Milan, 20122, Milan, Italy.
Cento V; Department Experimental Medicine and Surgery, University of Rome 'Tor Vergata', 00133, Rome, Italy. .
Ceccherini-Silberstein F; Department Experimental Medicine and Surgery, University of Rome 'Tor Vergata', 00133, Rome, Italy.
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Corporate Authors :
HCV Virology Italian Resistance Network (VIRONET-C)
Źródło :
Scientific reports [Sci Rep] 2018 Jun 12; Vol. 8 (1), pp. 8988. Date of Electronic Publication: 2018 Jun 12.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Genotype*
Drug Resistance, Viral/*genetics
Hepacivirus/*genetics
Hepatitis C/*genetics
Viral Nonstructural Proteins/*genetics
Adult ; Aged ; Female ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Prevalence
Czasopismo naukowe
Tytuł :
Hepatitis C virus drug resistance associated substitutions and their clinical relevance: Update 2018.
Autorzy :
Sorbo MC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Cento V; Residency program in Microbiology and Virology, Università degli Studi di Milano. Milan, Italy. Electronic address: .
Di Maio VC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Howe AYM; Centre for Excellence in HIV/AIDS, St Paul's Hospital, Vancouver, BC, Canada.
Garcia F; Clinical Microbiology Service, Hospital Universitario San Cecilio, Granada, Spain.
Perno CF; Department of Oncology and Oncohematology, Università degli Studi di Milano. Milan, Italy. Electronic address: .
Ceccherini-Silberstein F; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy. Electronic address: .
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Źródło :
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy [Drug Resist Updat] 2018 Mar; Vol. 37, pp. 17-39. Date of Electronic Publication: 2018 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Resistance, Viral*/genetics
Antiviral Agents/*therapeutic use
Hepacivirus/*drug effects
Hepatitis C, Chronic/*drug therapy
Viral Nonstructural Proteins/*antagonists & inhibitors
Animals ; Drug Design ; Genotype ; Hepacivirus/genetics ; Hepatitis C, Chronic/virology ; Humans ; Molecular Targeted Therapy ; Mutation ; Treatment Failure ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Frequent NS5A and multiclass resistance in almost all HCV genotypes at DAA failures: What are the chances for second-line regimens?
Autorzy :
Di Maio VC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Cento V; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Aragri M; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Paolucci S; Molecular Virology, Policlinic Foundation San Matteo, Pavia, Italy.
Pollicino T; Department of Internal Medicine, University Hospital of Messina, Messina, Italy.
Coppola N; Infectious Diseases and Viral Hepatitis Unit, University of Campania Luigi Vanvitelli, Naples, Italy.
Bruzzone B; Hygiene Unit, IRCCS AOU San Martino-IST, Genoa, Italy.
Ghisetti V; Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, ASL Città di Torino, Turin, Italy.
Zazzi M; Virology, Siena University Hospital, Siena, Italy.
Brunetto M; Hepatology Unit and Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses - University Hospital of Pisa, Italy.
Bertoli A; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Barbaliscia S; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Galli S; Microbiology and Virology Unit, Sant'Orsola-Malpighi Hospital-Bologna, Italy.
Gennari W; Microbiology Laboratory, University Hospital, Modena, Italy.
Baldanti F; Molecular Virology, Policlinic Foundation San Matteo, Pavia, Italy.
Raimondo G; Department of Internal Medicine, University Hospital of Messina, Messina, Italy.
Perno CF; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Ceccherini-Silberstein F; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy. Electronic address: .
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Corporate Authors :
HCV Virology Italian Resistance Network (VIRONET-C)
Źródło :
Journal of hepatology [J Hepatol] 2018 Mar; Vol. 68 (3), pp. 597-600. Date of Electronic Publication: 2017 Sep 20.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents*/classification
Antiviral Agents*/pharmacology
Hepacivirus*/drug effects
Hepacivirus*/genetics
Hepatitis C, Chronic*/drug therapy
Hepatitis C, Chronic*/virology
Retreatment/*methods
Drug Resistance, Viral ; Humans ; Treatment Outcome
Raport
Tytuł :
Optimal cure rate by personalized HCV regimens in real-life: a proof-of-concept study.
Autorzy :
Cento V; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Aragri M; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Teti E; Infectious Diseases, Policlinic Foundation of Rome Tor Vergata, Rome, Italy.
Polilli E; Infectious Disease Unit, 'Spirito Santo' General Hospital, Pescara, Italy.
Bertoli A; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Foroghi L; Infectious Diseases, Policlinic Foundation of Rome Tor Vergata, Rome, Italy.
Barbaliscia S; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Di Maio VC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Pieri A; Infectious Disease Unit, 'Spirito Santo' General Hospital, Pescara, Italy.
Pace Palitti V; Infectious Disease Unit, 'Spirito Santo' General Hospital, Pescara, Italy.
Sarmati L; Infectious Diseases, Policlinic Foundation of Rome Tor Vergata, Rome, Italy.
Parruti G; Infectious Disease Unit, 'Spirito Santo' General Hospital, Pescara, Italy.
Andreoni M; Infectious Diseases, Policlinic Foundation of Rome Tor Vergata, Rome, Italy.
Perno CF; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Ceccherini-Silberstein F; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
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Źródło :
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2017 Dec 01; Vol. 72 (12), pp. 3420-3424.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*administration & dosage
Hepatitis C, Chronic/*drug therapy
Precision Medicine/*methods
Administration, Oral ; Antiviral Agents/pharmacology ; Genotype ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Humans ; Microbial Sensitivity Tests ; Proof of Concept Study ; RNA, Viral/blood ; Sequence Analysis, DNA ; Sustained Virologic Response ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Exploring resistance pathways for first-generation NS3/4A protease inhibitors boceprevir and telaprevir using Bayesian network learning.
Autorzy :
Cuypers L; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49, box 1040, 3000 Leuven, Belgium. Electronic address: .
Libin P; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49, box 1040, 3000 Leuven, Belgium; Artificial Intelligence Lab, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address: .
Schrooten Y; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49, box 1040, 3000 Leuven, Belgium. Electronic address: .
Theys K; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49, box 1040, 3000 Leuven, Belgium. Electronic address: .
Di Maio VC; Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome, Italy. Electronic address: di.maio@med.uniroma2.it.
Cento V; Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome, Italy. Electronic address: .
Lunar MM; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address: .
Nevens F; University Hospitals Leuven, Department of Hepatology, Herestraat 49, 3000 Leuven, Belgium. Electronic address: .
Poljak M; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address: .
Ceccherini-Silberstein F; Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome, Italy. Electronic address: .
Nowé A; Artificial Intelligence Lab, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address: .
Van Laethem K; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49, box 1040, 3000 Leuven, Belgium. Electronic address: .
Vandamme AM; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49, box 1040, 3000 Leuven, Belgium; Center for Global Health and Tropical Medicine, Microbiology Unit, Institute for Hygiene and Tropical Medicine, University Nova de Lisboa, Rua da Junqueira 100, 1349-008 Lisbon, Portugal. Electronic address: .
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Źródło :
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2017 Sep; Vol. 53, pp. 15-23. Date of Electronic Publication: 2017 May 09.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Carrier Proteins/*genetics
Drug Resistance, Viral/*genetics
Hepacivirus/*genetics
Hepatitis C, Chronic/*drug therapy
Oligopeptides/*therapeutic use
Proline/*analogs & derivatives
Viral Nonstructural Proteins/*genetics
Amino Acid Substitution ; Antiviral Agents/therapeutic use ; Bayes Theorem ; Cohort Studies ; Databases, Genetic ; Europe/epidemiology ; Female ; Genotype ; Hepacivirus/classification ; Hepacivirus/drug effects ; Hepacivirus/isolation & purification ; Hepatitis C, Chronic/epidemiology ; Hepatitis C, Chronic/virology ; Humans ; Intracellular Signaling Peptides and Proteins ; Male ; Middle Aged ; Mutation, Missense ; Proline/therapeutic use ; Protease Inhibitors/therapeutic use ; RNA, Viral/genetics
Czasopismo naukowe
Tytuł :
Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens.
Autorzy :
Cento V; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Nguyen THT; INSERM, Université Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France.
Di Carlo D; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Biliotti E; Tropical Diseases, Umberto I Hospital - 'Sapienza' University, Rome, Italy.
Gianserra L; Infectious Diseases, Sant'Andrea Hospital - 'Sapienza' University, Rome, Italy.
Lenci I; Hepatology Unit, Polyclinic of Rome Tor Vergata, Rome, Italy.
Di Paolo D; Hepatology Unit, Polyclinic of Rome Tor Vergata, Rome, Italy.
Calvaruso V; Gastroenterology, 'P. Giaccone' University Hospital, Palermo, Italy.
Teti E; Infectious Diseases, Polyclinic of Rome Tor Vergata, Rome, Italy.
Cerrone M; Clinic of Infectious Disease, Department of Health Sciences, San Paolo University Hospital, University of Milan, Milan, Italy.
Romagnoli D; Department of Biomedical, Metabolic and Neural Sciences, NOCSAE Baggiovara, Baggiovara, Modena, Italy.
Melis M; Infectious Diseases Unit, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.
Danieli E; Infectious Diseases, AO Ospedale Niguarda Cà Granda, Milan, Italy.
Menzaghi B; Infectious Diseases, Ospedale di circolo di Busto Arsizio, Busto Arsizio, Varese, Italy.
Polilli E; Infectious Disease Unit, 'Spirito Santo' General Hospital, Pescara, Italy.
Siciliano M; Gastroenterology, Catholic University of Rome, Rome, Italy.
Nicolini LA; University of Genoa (DISSAL) Infectious Diseases Unit/AOU IRCCS San Martino-IST, Genoa, Italy.
Di Biagio A; University of Genoa (DISSAL) Infectious Diseases Unit/AOU IRCCS San Martino-IST, Genoa, Italy.
Magni CF; 1st Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italy.
Bolis M; 1st Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italy.
Antonucci FP; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Di Maio VC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Alfieri R; Istituto Nazionale di Genetica Molecolare (INGM) 'Romeo ed Enrica Invernizzi', Milan, Italy.
Sarmati L; Infectious Diseases, Polyclinic of Rome Tor Vergata, Rome, Italy.
Casalino P; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Bernardini S; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Micheli V; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, Milan, Italy.
Rizzardini G; 1st Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italy.; School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.
Parruti G; Infectious Disease Unit, 'Spirito Santo' General Hospital, Pescara, Italy.
Quirino T; Infectious Diseases, Ospedale di circolo di Busto Arsizio, Busto Arsizio, Varese, Italy.
Puoti M; Infectious Diseases, AO Ospedale Niguarda Cà Granda, Milan, Italy.
Babudieri S; Infectious Diseases Unit, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.
D'Arminio Monforte A; Clinic of Infectious Disease, Department of Health Sciences, San Paolo University Hospital, University of Milan, Milan, Italy.
Andreoni M; Infectious Diseases, Polyclinic of Rome Tor Vergata, Rome, Italy.
Craxì A; Gastroenterology, 'P. Giaccone' University Hospital, Palermo, Italy.
Angelico M; Hepatology Unit, Polyclinic of Rome Tor Vergata, Rome, Italy.
Pasquazzi C; Infectious Diseases, Sant'Andrea Hospital - 'Sapienza' University, Rome, Italy.
Taliani G; Tropical Diseases, Umberto I Hospital - 'Sapienza' University, Rome, Italy.
Guedj J; INSERM, Université Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France.
Perno CF; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Ceccherini-Silberstein F; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
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Źródło :
PloS one [PLoS One] 2017 May 18; Vol. 12 (5), pp. e0177352. Date of Electronic Publication: 2017 May 18 (Print Publication: 2017).
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Alanine Transaminase/*blood
Antiviral Agents/*pharmacology
Hepatitis C/*drug therapy
Viral Nonstructural Proteins/*antagonists & inhibitors
Administration, Oral ; Aged ; Alanine Transaminase/metabolism ; Antiviral Agents/administration & dosage ; Drug Therapy, Combination ; Female ; Hepacivirus/genetics ; Humans ; Interferons/pharmacology ; Kinetics ; Male ; Middle Aged ; Oligopeptides/administration & dosage ; Oligopeptides/pharmacology ; RNA, Viral/blood ; Ribavirin/administration & dosage ; Ribavirin/pharmacology ; Simeprevir/administration & dosage ; Simeprevir/pharmacology ; Sofosbuvir/administration & dosage ; Sofosbuvir/pharmacology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Multiclass HCV resistance to direct-acting antiviral failure in real-life patients advocates for tailored second-line therapies.
Autorzy :
Di Maio VC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Cento V; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Lenci I; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Aragri M; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Rossi P; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Barbaliscia S; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Melis M; Infectious Diseases Unit, University of Sassari, Sassari, Italy.
Verucchi G; Infection Disease Unit, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Magni CF; Division of Infectious Disease, Hospital Sacco of Milan, Milan, Italy.
Teti E; Infectious Diseases, University Hospital of Rome Tor Vergata, Rome, Italy.
Bertoli A; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Antonucci F; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Bellocchi MC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Micheli V; Unit of Microbiology, Hospital Sacco of Milan, Milan, Italy.
Masetti C; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Landonio S; Division of Infectious Disease, Hospital Sacco of Milan, Milan, Italy.
Francioso S; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Santopaolo F; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Pellicelli AM; Liver Disease Unit, Department of Liver Transplantation, San Camillo Forlanini Hospital, Rome, Italy.
Calvaruso V; Gastroenterology, 'P. Giaccone' University Hospital, Palermo, Italy.
Gianserra L; Infectious Diseases, Sant'Andrea Hospital - Sapienza University of Rome, Rome, Italy.
Siciliano M; Gastroenterology, Catholic University of Rome, Rome, Italy.
Romagnoli D; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Cozzolongo R; Department of Gastroenterology, Scientific Institute for Digestive Disease 'Saverio de Bellis' Hospital, Castellana Grotte, Bari, Italy.
Grieco A; Gastroenterology, Catholic University of Rome, Rome, Italy.
Vecchiet J; Infectious Disease Clinic, Hospital of Chieti, Chieti, Italy.
Morisco F; Gastroenterology, Department of Clinical Medicine and Surgery, University of Naples 'Federico II', Naples, Italy.
Merli M; Gastroenterology, Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
Brancaccio G; Infectious Diseases and Viral Hepatitis Unit, Second University, Naples, Italy.
Di Biagio A; Infectious Diseases Unit, Department of Social Health (DISSAL) of the University of Genoa, IRCCS S. Martino-IST, Genoa, Italy.
Loggi E; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Mastroianni CM; Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy.
Pace Palitti V; Hepatology Unit, Pescara General Hospital, Pescara, Italy.
Tarquini P; Infectious Disease, Hospital 'G. Mazzini', Teramo, Italy.
Puoti M; Department of Infectious Diseases, Hospital Niguarda Ca'Granda, Milan, Italy.
Taliani G; Infectious and Tropical Diseases Unit, Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
Sarmati L; Infectious Diseases, University Hospital of Rome Tor Vergata, Rome, Italy.
Picciotto A; Department of Internal Medicine, Gastroenterology Unit, University of Genova, Genoa, Italy.
Vullo V; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Caporaso N; Gastroenterology, Department of Clinical Medicine and Surgery, University of Naples 'Federico II', Naples, Italy.
Paoloni M; Infectious Disease Unit, Avezzano General Hospital, Avezzano, Italy.
Pasquazzi C; Infectious Diseases, Sant'Andrea Hospital - Sapienza University of Rome, Rome, Italy.
Rizzardini G; Division of Infectious Disease, Hospital Sacco of Milan, Milan, Italy.; School of Clinical Medicine, Faculty of Health Science University of the Witwatersrand, Johannesburg, South Africa.
Parruti G; Infectious Disease Unit, Pescara General Hospital, Pescara, Italy.
Craxì A; Gastroenterology, 'P. Giaccone' University Hospital, Palermo, Italy.
Babudieri S; Infectious Diseases Unit, University of Sassari, Sassari, Italy.
Andreoni M; Infectious Diseases, University Hospital of Rome Tor Vergata, Rome, Italy.
Angelico M; Hepatology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Perno CF; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Ceccherini-Silberstein F; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
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Corporate Authors :
HCV Italian Resistance Network Study Group
Źródło :
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2017 Apr; Vol. 37 (4), pp. 514-528. Date of Electronic Publication: 2017 Jan 20.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*therapeutic use
Drug Resistance, Viral/*genetics
Hepacivirus/*genetics
Hepatitis C, Chronic/*drug therapy
Viral Nonstructural Proteins/*genetics
Aged ; Drug Therapy, Combination ; Female ; Genotype ; Hepacivirus/drug effects ; Humans ; Interferons/therapeutic use ; Italy ; Male ; Middle Aged ; Mutation ; Recurrence ; Ribavirin/therapeutic use ; Sequence Analysis, DNA ; Sofosbuvir/therapeutic use ; Sustained Virologic Response ; Treatment Failure
Czasopismo naukowe
Tytuł :
Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy.
Autorzy :
Cuypers L; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49 - box 1040, 3000, Leuven, Belgium. .
Vrancken B; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49 - box 1040, 3000, Leuven, Belgium.
Fabeni L; National Institute for Infectious Diseases L. Spallanzani-IRCCS, Rome, Italy.
Marascio N; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49 - box 1040, 3000, Leuven, Belgium.; Department of Health Sciences, Institute of Microbiology, School of Medicine, University of 'Magna Graecia', Viale Europa, Germaneto, 88100, Catanzaro, Italy.
Cento V; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Di Maio VC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Aragri M; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Pineda-Peña AC; Global Health and Tropical Medicine, GHTM, Institute for Hygiene and Tropical Medicine, IHMT, University Nova de Lisboa, UNL, Rua da Junqueira 100, 1349-008, Lisbon, Portugal.; Molecular Biology and Immunology Department, Fundación Instituto de Immunología de Colombia (FIDIC), Basic Sciences Department, Universidad del Rosario, Bogotá, Colombia.
Schrooten Y; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49 - box 1040, 3000, Leuven, Belgium.
Van Laethem K; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49 - box 1040, 3000, Leuven, Belgium.
Balog D; Luciad, Computer Software, Gaston Geenslaan 11, 3001, Heverlee, Belgium.
Focà A; Department of Health Sciences, Institute of Microbiology, School of Medicine, University of 'Magna Graecia', Viale Europa, Germaneto, 88100, Catanzaro, Italy.
Torti C; Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, School of Medicine, University of 'Magna Graecia', Viale Europa, Germaneto, 88100, Catanzaro, Italy.
Nevens F; KU Leuven - University of Leuven, Department of Clinical and Experimental Medicine, Hepatology, Leuven, Belgium.; University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium.
Perno CF; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Vandamme AM; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Herestraat 49 - box 1040, 3000, Leuven, Belgium.; Global Health and Tropical Medicine, GHTM, Institute for Hygiene and Tropical Medicine, IHMT, University Nova de Lisboa, UNL, Rua da Junqueira 100, 1349-008, Lisbon, Portugal.
Ceccherini-Silberstein F; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
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Źródło :
BMC evolutionary biology [BMC Evol Biol] 2017 Mar 07; Vol. 17 (1), pp. 70. Date of Electronic Publication: 2017 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Hepacivirus/*physiology
Hepatitis C/*virology
Antiviral Agents/pharmacology ; Bayes Theorem ; Drug Resistance, Viral ; Genotype ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Hepatitis C/epidemiology ; Humans ; Italy/epidemiology ; Simeprevir/pharmacology
Czasopismo naukowe
Tytuł :
The HIV-1 reverse transcriptase polymorphism A98S improves the response to tenofovir disoproxil fumarate+emtricitabine-containing HAART both in vivo and in vitro.
Autorzy :
Alteri C; University of Rome Tor Vergata, Rome, Italy.
Surdo M; University of Rome Tor Vergata, Rome, Italy.
Di Maio VC; University of Rome Tor Vergata, Rome, Italy.
Di Santo F; University of Rome Tor Vergata, Rome, Italy.
Costa G; University 'Magna Graecia' of Catanzaro, Germaneto, CZ, Italy.
Parrotta L; University 'Magna Graecia' of Catanzaro, Germaneto, CZ, Italy.
Romeo I; University 'Magna Graecia' of Catanzaro, Germaneto, CZ, Italy.
Gori C; INMI 'L. Spallanzani', Rome, Italy.
Santoro MM; University of Rome Tor Vergata, Rome, Italy.
Fedele V; INMI 'L. Spallanzani', Rome, Italy.
Carta S; INMI 'L. Spallanzani', Rome, Italy.
Continenza F; INMI 'L. Spallanzani', Rome, Italy.
Pinnetti C; INMI 'L. Spallanzani', Rome, Italy.
Bellagamba R; INMI 'L. Spallanzani', Rome, Italy.
Liuzzi G; INMI 'L. Spallanzani', Rome, Italy.
Orchi N; INMI 'L. Spallanzani', Rome, Italy.
Latini A; San Gallicano Hospital, Rome, Italy.
Bertoli A; University of Rome Tor Vergata, Rome, Italy; University Hospital of Rome Tor Vergata, Rome, Italy.
Girardi E; INMI 'L. Spallanzani', Rome, Italy.
Alcaro S; University 'Magna Graecia' of Catanzaro, Germaneto, CZ, Italy.
Giuliani M; San Gallicano Hospital, Rome, Italy.
Petrosillo N; INMI 'L. Spallanzani', Rome, Italy.
Andreoni M; University of Rome Tor Vergata, Rome, Italy; University Hospital of Rome Tor Vergata, Rome, Italy.
Antinori A; INMI 'L. Spallanzani', Rome, Italy.
Monforte AD; University of Milan, Milan, Italy.
Ceccherini-Silberstein F; University of Rome Tor Vergata, Rome, Italy.
Artese A; University 'Magna Graecia' of Catanzaro, Germaneto, CZ, Italy.
Perno CF; University of Rome Tor Vergata, Rome, Italy; INMI 'L. Spallanzani', Rome, Italy; University Hospital of Rome Tor Vergata, Rome, Italy. Electronic address: .
Svicher V; University of Rome Tor Vergata, Rome, Italy. Electronic address: .
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Źródło :
Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2016 Dec; Vol. 7, pp. 1-7. Date of Electronic Publication: 2016 Jul 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiretroviral Therapy, Highly Active*
Anti-HIV Agents/*pharmacology
Emtricitabine/*pharmacology
HIV Infections/*drug therapy
HIV Reverse Transcriptase/*genetics
Tenofovir/*pharmacology
Adult ; Female ; HIV-1/drug effects ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic
Czasopismo naukowe
Tytuł :
Hepatitis C virus gene sequencing as a tool for precise genotyping in the era of new direct antiviral agents.
Autorzy :
Ceccherini Silberstein F; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Di Maio VC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Aragri M; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Ciotti M; Laboratory of Molecular Virology, Polyclinic Tor Vergata Foundation, Rome Italy.
Cento V; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Perno CF; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.; Laboratory of Molecular Virology, Polyclinic Tor Vergata Foundation, Rome Italy.
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Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2016 Mar; Vol. 63 (3), pp. 1058-9. Date of Electronic Publication: 2015 Jul 03.
Typ publikacji :
Letter
MeSH Terms :
Genotyping Techniques*
Sequence Analysis, RNA*
Hepacivirus/*genetics
Molecular Targeted Therapy
Opinia redakcyjna

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