Temat: "Diabetes Mellitus, Experimental" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice.
Autorzy:: Zhang C; Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China.
Zhang D; Shandong Provincial Engineering Laboratory of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Medicine and Nursing, Dezhou University, Dezhou, Shandong 253023, P.R. China.
Wang H; Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China.
Lin Q; Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China.
Li M; Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China.
Yuan J; Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China.
Gao G; Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China.
Dong J; Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2022 Mar; Vol. 25 (3). Date of Electronic Publication: 2022 Jan 18.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Experimental/*metabolism
Diabetes Mellitus, Type 2/*metabolism
Gluconeogenesis/*physiology
Hyperbaric Oxygenation/*methods
Insulin-Secreting Cells/*metabolism
Liver/*metabolism
Animals ; Apoptosis/physiology ; Blood Glucose/metabolism ; Blotting, Western ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/etiology ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/etiology ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Fasting/blood ; Glucose Tolerance Test/methods ; Humans ; Insulin/blood ; Insulin-Secreting Cells/cytology ; Male ; Mice, Inbred C57BL ; Mice

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Skocz do pozycji: 2.

Tytuł:: Metabolic impacts of cordycepin on hepatic proteomic expression in streptozotocin-induced type 1 diabetic mice.
Autorzy:: Parunyakul K; Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand.
Srisuksai K; Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand.
Charoenlappanit S; Functional Ingredients and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand.
Phaonakrop N; Functional Ingredients and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand.
Roytrakul S; Functional Ingredients and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand.
Fungfuang W; Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand.; Omics Center for Agriculture, Bioresources, Food and Health, Kasetsart University (OmiKU), Bangkok, Thailand.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2021 Aug 13; Vol. 16 (8), pp. e0256140. Date of Electronic Publication: 2021 Aug 13 (Print Publication: 2021).
Typ publikacji:: Journal Article
MeSH Terms:: Blood Glucose/*metabolism
Deoxyadenosines/*pharmacology
Diabetes Mellitus, Experimental/*pathology
Diabetes Mellitus, Type 1/*pathology
Insulin/*metabolism
Liver/*pathology
Proteome/*drug effects
Animals ; Antifungal Agents/pharmacology ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/metabolism ; Disease Models, Animal ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Signal Transduction

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Skocz do pozycji: 3.

Tytuł:: Modulatory effect of isopulegol on hepatic key enzymes of glucose metabolism in high-fat diet/streptozotocin-induced diabetic rats.
Autorzy:: Kalaivani K; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, India.
Sankaranarayanan C; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, India.; Pokaż więcej
Źródło:: Archives of physiology and biochemistry [Arch Physiol Biochem] 2021 Aug; Vol. 127 (4), pp. 318-326. Date of Electronic Publication: 2019 Jul 10.
Typ publikacji:: Journal Article
MeSH Terms:: Blood Glucose/*analysis
Carbohydrate Metabolism/*drug effects
Cyclohexane Monoterpenes/*pharmacology
Diabetes Mellitus, Experimental/*drug therapy
Diet, High-Fat/*adverse effects
Liver/*enzymology
Streptozocin/*toxicity
Animals ; Antibiotics, Antineoplastic/toxicity ; Diabetes Mellitus, Experimental/etiology ; Diabetes Mellitus, Experimental/pathology ; Fructose-Bisphosphatase/metabolism ; Glucose-6-Phosphatase/metabolism ; Hexokinase/metabolism ; Hypoglycemic Agents/pharmacology ; Insulin/blood ; Male ; Rats ; Rats, Wistar

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Skocz do pozycji: 4.

Tytuł:: Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers.
Autorzy:: Abd El-Hameed AM; Chemistry Department, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah, 30002, Saudi Arabia. afnan_.
Yousef AI; Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt. ahmedismail_.
Abd El-Twab SM; Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt. .
El-Shahawy AAG; Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, 62511, Egypt. .
Abdel-Moneim A; Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt. .; Pokaż więcej
Źródło:: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2021 Feb; Vol. 86 (2), pp. 179-189.
Typ publikacji:: Journal Article
MeSH Terms:: Chitosan*
Diabetes Mellitus, Experimental/*drug therapy
Glucosides/*pharmacology
Liver/*drug effects
Nanoparticles/*chemistry
Stilbenes/*pharmacology
Animals ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Glucose/metabolism ; Glucosides/therapeutic use ; Inflammation ; Lipid Peroxidation ; Liver/metabolism ; Male ; Metformin/pharmacology ; Metformin/therapeutic use ; Niacinamide ; Oxidative Stress ; Protective Agents/pharmacology ; Rats ; Rats, Wistar ; Stilbenes/therapeutic use ; Streptozocin/toxicity

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Skocz do pozycji: 5.

Tytuł:: Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats.
Autorzy:: Fink BD; Department of Internal Medicine/Division of Endocrinology and Metabolism, University of Iowa, The Iowa City Veterans Affairs Medical Center, Iowa City, IA, USA.
Yu L; Department of Biochemistry, NMR Core facility, University of Iowa, Iowa City, IA, USA.
Coppey L; Department of Internal Medicine/Division of Endocrinology and Metabolism, University of Iowa, The Iowa City Veterans Affairs Medical Center, Iowa City, IA, USA.
Obrosov A; Department of Internal Medicine/Division of Endocrinology and Metabolism, University of Iowa, The Iowa City Veterans Affairs Medical Center, Iowa City, IA, USA.
Shevalye H; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Kerns RJ; Department of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, Iowa City, IA, USA.
Yorek MA; Department of Internal Medicine/Division of Endocrinology and Metabolism, University of Iowa, The Iowa City Veterans Affairs Medical Center, Iowa City, IA, USA.
Sivitz WI; Department of Internal Medicine/Division of Endocrinology and Metabolism, University of Iowa, The Iowa City Veterans Affairs Medical Center, Iowa City, IA, USA.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2021 Feb; Vol. 9 (1), pp. e00701.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Diabetes Mellitus, Experimental/*metabolism
Diabetes Mellitus, Type 2/*metabolism
Fatty Liver/*metabolism
Liver/*drug effects
Obesity/*metabolism
Organophosphorus Compounds/*pharmacology
Ubiquinone/*analogs & derivatives
Animals ; Blood Glucose/drug effects ; Cell Respiration/drug effects ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Type 2/blood ; Diet, High-Fat ; Fatty Liver/blood ; Insulin/blood ; Lipid Metabolism/drug effects ; Liver/metabolism ; Male ; Membrane Potential, Mitochondrial/drug effects ; Metabolomics ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/pathology ; Mitochondria, Liver/physiology ; Obesity/blood ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley ; Ubiquinone/pharmacology ; Rats

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Skocz do pozycji: 6.

Tytuł:: Hypolipidemic effect of Alisma orientale (Sam.) Juzep on gut microecology and liver transcriptome in diabetic rats.
Autorzy:: Xu X; Fujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou, China.
Li L; Fujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou, China.
Zhang Y; Fujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou, China.
Lu X; Fujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou, China.
Lin W; Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.
Wu S; Fujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou, China.
Qin X; Fujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou, China.
Xu R; Fujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou, China.
Lin W; Fujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Oct 09; Vol. 15 (10), pp. e0240616. Date of Electronic Publication: 2020 Oct 09 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alisma/*chemistry
Diabetes Mellitus, Experimental/*drug therapy
Gastrointestinal Microbiome/*drug effects
Liver/*metabolism
Animals ; Cholestenones/pharmacology ; Cholesterol/blood ; Cholesterol, LDL/blood ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/pathology ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Gene Expression Regulation/drug effects ; Humans ; Liver/drug effects ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Rats ; Transcriptome/drug effects ; Triterpenes/chemistry ; Triterpenes/pharmacology

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Skocz do pozycji: 7.

Tytuł:: Anti-diabetic, anti-hyperlipidemic and hepatoprotective potential of shaddock (Citrus maxima) peel extract.
Autorzy:: Ani PN; Department of Nutrition and Dietetics, University of Nigeria, Nigeria.
Ochu KE; Department of Nutrition and Dietetics, University of Nigeria, Nigeria.; Pokaż więcej
Źródło:: Acta scientiarum polonorum. Technologia alimentaria [Acta Sci Pol Technol Aliment] 2020 Jul-Sep; Vol. 19 (3), pp. 271-278.
Typ publikacji:: Journal Article
MeSH Terms:: Citrus*
Fruit*
Diabetes Mellitus, Experimental/*blood
Hypoglycemic Agents/*pharmacology
Hypolipidemic Agents/*pharmacology
Liver/*drug effects
Plant Extracts/*pharmacology
Animals ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Hyperlipidemias/blood ; Hyperlipidemias/etiology ; Hyperlipidemias/prevention & control ; Lipids/blood ; Liver/enzymology ; Male ; Phytotherapy ; Plant Epidermis ; Plant Extracts/therapeutic use ; Protective Agents ; Rats, Wistar

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Skocz do pozycji: 8.

Tytuł:: GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats.
Autorzy:: Hosseini Dastgerdi A; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Sharifi M; Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Soltani N; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Nov 30; Vol. 11 (1), pp. 23155. Date of Electronic Publication: 2021 Nov 30.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Experimental/*metabolism
Insulin/*metabolism
Liver/*metabolism
gamma-Aminobutyric Acid/*administration & dosage
Animals ; Blood Glucose/analysis ; Body Weight/drug effects ; Endocrinology ; Female ; Gluconeogenesis/genetics ; Glucose/metabolism ; Glucose Clamp Technique ; Glucose Tolerance Test ; Glycogen/metabolism ; Hyperinsulinism/metabolism ; Insulin Resistance ; Male ; Rats ; Rats, Wistar ; Signal Transduction

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Skocz do pozycji: 9.

Tytuł:: Protective effect of carvacrol on liver injury in type 2 diabetic db/db mice.
Autorzy:: Zhao W; Department of Endocrinology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550003, P.R. China.
Chen L; Department of Prevention and Health Care, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550003, P.R. China.
Zhou H; Department of Endocrinology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550003, P.R. China.
Deng C; Department of Endocrinology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550003, P.R. China.
Han Q; Department of Endocrinology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550003, P.R. China.
Chen Y; Department of Endocrinology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550003, P.R. China.
Wu Q; Department of Endocrinology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550003, P.R. China.
Li S; Department of Endocrinology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550003, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2021 Nov; Vol. 24 (5). Date of Electronic Publication: 2021 Aug 26.
Typ publikacji:: Journal Article
MeSH Terms:: Cymenes/*pharmacology
Liver/*injuries
Liver/*metabolism
Protective Agents/*pharmacology
Animals ; Antigens, CD/metabolism ; Blood Glucose ; Cymenes/therapeutic use ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Type 2 ; Insulin Receptor Substrate Proteins/metabolism ; Insulin Resistance ; Liver/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Proto-Oncogene Proteins c-akt ; Receptor, Insulin/metabolism ; Signal Transduction/drug effects ; Toll-Like Receptor 4/metabolism

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Skocz do pozycji: 10.

Tytuł:: The potential hepatoprotective effects of lovastatin combined with oral hypoglycemic agents in streptozotocin-induced diabetes in rats.
Autorzy:: Sharkawi SMZ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.
El-Shoura EAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Abo-Youssef AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Hemeida RAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Deraya University, Menia, Egypt.; Pokaż więcej
Źródło:: Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2020 Apr; Vol. 42 (2), pp. 165-173. Date of Electronic Publication: 2020 Mar 02.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Experimental/*drug therapy
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
Hypoglycemic Agents/*therapeutic use
Liver/*drug effects
Lovastatin/*therapeutic use
Animals ; Biomarkers/metabolism ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/metabolism ; Drug Therapy, Combination ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hypoglycemic Agents/administration & dosage ; Liver/metabolism ; Liver/pathology ; Liver Function Tests ; Lovastatin/administration & dosage ; Male ; Nitric Oxide/blood ; Rats ; Tumor Necrosis Factor-alpha/blood

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Skocz do pozycji: 11.

Tytuł:: The effect of dioxidovanadium complex (V) on hepatic function in streptozotocin-induced diabetic rats.
Autorzy:: Sibiya S; Schools of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Msibi B; Schools of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Khathi A; Schools of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Sibiya N; Pharmacology Division, Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa.
Booysen I; School of Chemistry and Physics, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
Ngubane P; Schools of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2019 Dec; Vol. 97 (12), pp. 1169-1175. Date of Electronic Publication: 2019 Sep 06.
Typ publikacji:: Journal Article
MeSH Terms:: Coordination Complexes/*pharmacology
Diabetes Mellitus, Experimental/*physiopathology
Liver/*drug effects
Liver/*physiopathology
Vanadium/*chemistry
Animals ; Blood Glucose/metabolism ; Body Weight/drug effects ; C-Reactive Protein/metabolism ; Coordination Complexes/therapeutic use ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/pathology ; Lipids/blood ; Liver/pathology ; Male ; Organ Size/drug effects ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley

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Skocz do pozycji: 12.

Tytuł:: The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats .
Autorzy:: Mutavdzin S; Institute of Medical Physiology 'Richard Burian', Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Gopcevic K; Institute of Chemistry in Medicine 'Prof. Dr. Petar Matavulj', Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Stankovic S; Centre of Medical Biochemistry, Clinical Centre of Serbia, Belgrade, Serbia.
Jakovljevic Uzelac J; Institute of Medical Physiology 'Richard Burian', Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Labudovic Borovic M; Institute of Histology and Embryology 'Aleksandar Dj. Kostic', Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Djuric D; Institute of Medical Physiology 'Richard Burian', Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2019 Sep; Vol. 97 (9), pp. 893-901. Date of Electronic Publication: 2019 Jul 11.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Experimental/*enzymology
Folic Acid/*pharmacology
Kidney/*drug effects
Liver/*drug effects
Matrix Metalloproteinases/*metabolism
Myocardium/*enzymology
Myocardium/*pathology
Animals ; Biomarkers/blood ; Biomarkers/metabolism ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Folic Acid/administration & dosage ; Kidney/metabolism ; Liver/metabolism ; Male ; Rats ; Rats, Wistar

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Skocz do pozycji: 13.

Tytuł:: Dietary supplementation of jute leaf (Corchorus olitorius) modulates hepatic delta-aminolevulinic acid dehydratase (δ-ALAD) activity and oxidative status in high-fat fed/low streptozotocin-induced diabetic rats.
Autorzy:: Saliu JA; Department of Biochemistry, Adekunle Ajasin University, Akungba Akoko, Nigeria.; Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria.; Biological Sciences, Center for Natural Sciences and Exact, Federal University of Santa Maria, Santa Maria, Brazil.
Ademiluyi AO; Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria.; Biological Sciences, Center for Natural Sciences and Exact, Federal University of Santa Maria, Santa Maria, Brazil.
Boligon AA; Pharmaceutical Sciences, Federal University of Santa Maria, Santa Maria, Brazil.
Oboh G; Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
Schetinger MRC; Biological Sciences, Center for Natural Sciences and Exact, Federal University of Santa Maria, Santa Maria, Brazil.
Rocha JBT; Biological Sciences, Center for Natural Sciences and Exact, Federal University of Santa Maria, Santa Maria, Brazil.; Pokaż więcej
Źródło:: Journal of food biochemistry [J Food Biochem] 2019 Aug; Vol. 43 (8), pp. e12949. Date of Electronic Publication: 2019 Jun 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Corchorus/*chemistry
Diabetes Mellitus, Experimental/*drug therapy
Liver/*enzymology
Oxidative Stress/*drug effects
Plant Extracts/*administration & dosage
Porphobilinogen Synthase/*metabolism
Animals ; Antioxidants/administration & dosage ; Catalase/metabolism ; Diabetes Mellitus, Experimental/etiology ; Diabetes Mellitus, Experimental/metabolism ; Diet, High-Fat/adverse effects ; Dietary Supplements/analysis ; Humans ; Liver/drug effects ; Male ; Plant Leaves/chemistry ; Porphobilinogen Synthase/genetics ; Rats ; Rats, Wistar ; Streptozocin

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Skocz do pozycji: 14.

Tytuł:: A histopathological, immunohistochemical and biochemical investigation of the antidiabetic effects of the Pistacia terebinthus in diabetic rats.
Autorzy:: Uyar A; Department of Pathology, Veterinary Faculty, Mustafa Kemal University, Hatay, Turkey.
Abdulrahman NT; Department of Pathology, Veterinary Faculty, Yuzuncu Yil University, Van, Turkey.; Pokaż więcej
Źródło:: Biotechnic & histochemistry : official publication of the Biological Stain Commission [Biotech Histochem] 2020 Feb; Vol. 95 (2), pp. 92-104. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Experimental/*metabolism
Hypoglycemic Agents/*pharmacology
Liver/*drug effects
Pistacia/*metabolism
Animals ; Antioxidants/pharmacology ; Blood Glucose/drug effects ; Diabetes Mellitus, Experimental/chemically induced ; Immunohistochemistry/methods ; Liver/metabolism ; Male ; Rats, Wistar

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Skocz do pozycji: 15.

Tytuł:: Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.
Autorzy:: Zhu Y; Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Su Y; Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Zhang J; Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Zhang Y; Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Li Y; Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Han Y; Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Dong X; Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Li W; Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Li W; Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei, Anhui 230032, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2021 Jun; Vol. 23 (6). Date of Electronic Publication: 2021 Apr 13.
Typ publikacji:: Journal Article
MeSH Terms:: AMP-Activated Protein Kinases/*metabolism
Autophagy/*drug effects
Diabetes Mellitus, Type 2/*metabolism
Liver/*injuries
Liver/*metabolism
Saponins/*pharmacology
TOR Serine-Threonine Kinases/*metabolism
Triterpenes/*pharmacology
Animals ; Astragalus propinquus ; Diabetes Mellitus, Experimental/metabolism ; Diet, High-Fat ; Glucose/metabolism ; Homeostasis ; Insulin Resistance ; Liver/pathology ; Male ; Oxidative Stress/drug effects ; Quality of Life ; Rats ; Rats, Sprague-Dawley ; Streptozocin/pharmacology

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Skocz do pozycji: 16.

Tytuł:: Improving hepatic mitochondrial biogenesis as a postulated mechanism for the antidiabetic effect of Spirulina platensis in comparison with metformin.
Autorzy:: Oriquat GA; a Faculty of Pharmacy and Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.
Ali MA; b Department of Pharmacology & Therapeutics, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, PO Box 37, Alexandria 21648, Egypt.
Mahmoud SA; c Department of Biochemistry, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.
Eid RMHM; d Department of Physiology, Faculty of Medicine, Aswan University, Aswan 81528, Egypt.
Hassan R; e Department of Biochemistry, Faculty of Physical Therapy, Pharos University in Alexandria, Alexandria 21648, Egypt.
Kamel MA; c Department of Biochemistry, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.; Pokaż więcej
Źródło:: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2019 Apr; Vol. 44 (4), pp. 357-364. Date of Electronic Publication: 2018 Sep 12.
Typ publikacji:: Journal Article
MeSH Terms:: Organelle Biogenesis*
Spirulina*
Blood Glucose/*drug effects
Diabetes Mellitus, Experimental/*drug therapy
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*pharmacology
Liver/*drug effects
Metformin/*pharmacology
Mitochondria, Liver/*drug effects
Probiotics/*pharmacology
Adiponectin/blood ; Animals ; Biomarkers/blood ; Blood Glucose/metabolism ; DNA Copy Number Variations ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/pathology ; Diet, High-Fat ; Insulin/blood ; Lipids/blood ; Liver/metabolism ; Liver/pathology ; Male ; Mitochondria, Liver/metabolism ; Mitochondria, Liver/pathology ; Rats, Wistar ; Signal Transduction/drug effects ; Sterol Regulatory Element Binding Protein 1/genetics ; Sterol Regulatory Element Binding Protein 1/metabolism ; Streptozocin ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Tumor Necrosis Factor-alpha/blood

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Skocz do pozycji: 17.

Tytuł:: CB1 receptor blockade ameliorates hepatic fat infiltration and inflammation and increases Nrf2-AMPK pathway in a rat model of severely uncontrolled diabetes.
Autorzy:: Chang E; Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Seoul, Republic of Korea.
Kim DH; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Yang H; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Lee DH; Severance Biomedical Science Institute, Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Bae SH; Severance Biomedical Science Institute, Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Park CY; Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2018 Oct 26; Vol. 13 (10), pp. e0206152. Date of Electronic Publication: 2018 Oct 26 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Diabetes Mellitus, Experimental/*pathology
Fatty Liver/*prevention & control
Liver/*drug effects
Rimonabant/*pharmacology
Adenylate Kinase/metabolism ; Animals ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/metabolism ; Fatty Liver/etiology ; Fatty Liver/pathology ; Inflammation/pathology ; Inflammation/prevention & control ; Liver/pathology ; NF-E2-Related Factor 2/metabolism ; Obesity/complications ; Obesity/drug therapy ; Obesity/pathology ; Rats ; Rats, Inbred OLETF ; Rats, Long-Evans ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Severity of Illness Index ; Signal Transduction/drug effects

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Skocz do pozycji: 18.

Tytuł:: Chlorophyllin supplementation modulates hyperglycemia-induced oxidative stress and apoptosis in liver of streptozotocin-administered mice.
Autorzy:: Patar AK; Department of Biochemistry, North Eastern Hill University, Shillong, Meghalaya, India.
Sharma A; Department of Biochemistry, North Eastern Hill University, Shillong, Meghalaya, India.
Syiem D; Department of Biochemistry, North Eastern Hill University, Shillong, Meghalaya, India.
Bhan S; Department of Biochemistry, North Eastern Hill University, Shillong, Meghalaya, India.; Pokaż więcej
Źródło:: BioFactors (Oxford, England) [Biofactors] 2018 Sep; Vol. 44 (5), pp. 418-430. Date of Electronic Publication: 2018 Oct 10.
Typ publikacji:: Journal Article
MeSH Terms:: Chlorophyllides/*administration & dosage
Diabetes Mellitus, Experimental/*diet therapy
Hyperglycemia/*diet therapy
Liver/*drug effects
Animals ; Antioxidants/administration & dosage ; Apoptosis/drug effects ; Catalase/genetics ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/pathology ; Dietary Supplements ; Humans ; Hyperglycemia/genetics ; Hyperglycemia/pathology ; Liver/pathology ; Mice ; Mice, Inbred NOD ; Oxidative Stress/drug effects ; Superoxide Dismutase/genetics ; Superoxide Dismutase-1/genetics

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Skocz do pozycji: 19.

Tytuł:: Betanin exhibits significant potential as an antihyperglycemic and attenuating the glycoprotein components in streptozotocin-nicotinamide-induced experimental rats.
Autorzy:: Indumathi D; a Department of Biochemistry and Biotechnology, Faculty of Science , Annamalai University , Annamalainagar , India.
Sujithra K; a Department of Biochemistry and Biotechnology, Faculty of Science , Annamalai University , Annamalainagar , India.
Srinivasan S; a Department of Biochemistry and Biotechnology, Faculty of Science , Annamalai University , Annamalainagar , India.; b Postgraduate and Research Department of Biochemistry , Government Arts College For Women , Krishnagiri , India.
Vinothkumar V; a Department of Biochemistry and Biotechnology, Faculty of Science , Annamalai University , Annamalainagar , India.; Pokaż więcej
Źródło:: Toxicology mechanisms and methods [Toxicol Mech Methods] 2018 Sep; Vol. 28 (7), pp. 547-554. Date of Electronic Publication: 2018 May 21.
Typ publikacji:: Comparative Study; Journal Article; Retracted Publication
MeSH Terms:: Dietary Supplements*
Betacyanins/*therapeutic use
Diabetes Mellitus, Experimental/*therapy
Hypoglycemic Agents/*therapeutic use
Kidney/*metabolism
Liver/*metabolism
Pancreas/*metabolism
Animals ; Betacyanins/adverse effects ; Biomarkers/blood ; Biomarkers/metabolism ; Body Weight/drug effects ; Combined Modality Therapy/adverse effects ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Glyburide/therapeutic use ; Glycoproteins/blood ; Glycoproteins/metabolism ; Hyperglycemia/prevention & control ; Hypoglycemic Agents/adverse effects ; Kidney/drug effects ; Kidney/pathology ; Liver/drug effects ; Liver/pathology ; Male ; Niacinamide/poisoning ; Organ Specificity ; Pancreas/drug effects ; Pancreas/pathology ; Random Allocation ; Rats, Wistar ; Streptozocin/toxicity

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Skocz do pozycji: 20.

Tytuł:: Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats.
Autorzy:: Xie X; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.; Department of Anesthesiology, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Yan D; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.
Li H; Department of Anesthesiology, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Zhu Q; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.
Li J; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.
Fang YP; Department of General Surgery, Huizhou First Hospital, Huizhou, Guangdong, China.
Cheung CW; Department of Anesthesiology, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Irwin MG; Department of Anesthesiology, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Xia Z; Department of Anesthesiology, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Lian Q; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.; Pokaż więcej
Źródło:: Journal of diabetes research [J Diabetes Res] 2018 Aug 16; Vol. 2018, pp. 6254340. Date of Electronic Publication: 2018 Aug 16 (Print Publication: 2018).
Typ publikacji:: Journal Article
MeSH Terms:: Adiponectin/*biosynthesis
Diabetes Mellitus, Experimental/*therapy
Diabetes Mellitus, Type 1/*therapy
Genetic Therapy/*methods
Liver/*metabolism
Nerve Tissue Proteins/*metabolism
Non-alcoholic Fatty Liver Disease/*prevention & control
Adiponectin/genetics ; Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Biomarkers/blood ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/metabolism ; Gene Expression Regulation ; Liver/pathology ; Male ; Nerve Tissue Proteins/genetics ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Sprague-Dawley ; Signal Transduction ; Triglycerides/blood

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