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Tytuł :
Impacts of chronic exposure to sublethal diazepam on behavioral traits of female and male zebrafish (Danio rerio).
Autorzy :
Chen K; Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China.
Wu M; Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China.
Chen C; Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China.
Xu H; Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China.
Wu X; Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China.
Qiu X; Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China; Faculty of Agriculture, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Jan 15; Vol. 208, pp. 111747. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article
MeSH Terms :
Toxicity Tests, Chronic*
Diazepam/*toxicity
Water Pollutants, Chemical/*toxicity
Zebrafish/*physiology
Acetylcholinesterase/metabolism ; Animals ; Brain/drug effects ; Diazepam/administration & dosage ; Female ; Male ; Motor Activity/drug effects ; Swimming ; Zebrafish/metabolism ; gamma-Aminobutyric Acid/pharmacology
Czasopismo naukowe
Tytuł :
Possible mechanism and potential application of anti-opioid effect of diazepam-binding inhibitor.
Autorzy :
Qin W; Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China. Electronic address: .
Qu H; Center for Bioinformatics, State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China.
Pan L; Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China.
Sun W; Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China.
Chen Y; Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China; State Key Laboratory of Membrane Biology, Peking University, Beijing 100871, China. Electronic address: .
Wu C; State Key Laboratory of Membrane Biology, Peking University, Beijing 100871, China.
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118836. Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article
MeSH Terms :
Analgesics, Opioid/*pharmacology
Diazepam Binding Inhibitor/*pharmacology
Morphine/*pharmacology
Narcotic Antagonists/*pharmacology
Analgesics, Opioid/administration & dosage ; Animals ; Diazepam Binding Inhibitor/administration & dosage ; Dose-Response Relationship, Drug ; Drug Tolerance ; Electric Stimulation ; Male ; Mice ; Morphine/administration & dosage ; Naloxone/pharmacology ; Narcotic Antagonists/administration & dosage ; Nitric Oxide/metabolism ; Opioid-Related Disorders/drug therapy ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/metabolism ; Swine ; Tail ; Vocalization, Animal/drug effects
Czasopismo naukowe
Tytuł :
Nose-to-Brain Delivery of Diazepam from an Intranasal Aqua-Triggered In-Situ (ATIS) Gelling Microemulsion: Monitoring Brain Uptake by Microdialysis.
Autorzy :
Bachhav SS; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga (E), Mumbai, Maharashtra, 400019, India.
Dighe V; National Center for Preclinical Reproductive and Genetic Toxicology, National Institute for Research in Reproductive Health (NIRRH), ICMR, J. M. Street, Parel, Mumbai, 400012, India.
Mali N; Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Gogtay NJ; Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Thatte UM; Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Devarajan PV; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga (E), Mumbai, Maharashtra, 400019, India. .
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Źródło :
European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2020 Dec; Vol. 45 (6), pp. 785-799.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*administration & dosage
Anticonvulsants/*pharmacokinetics
Brain/*metabolism
Diazepam/*administration & dosage
Diazepam/*pharmacokinetics
Adhesiveness ; Administration, Intranasal ; Animals ; Anticonvulsants/adverse effects ; Diazepam/adverse effects ; Drug Compounding ; Drug Delivery Systems ; Emulsions ; Extracellular Fluid/metabolism ; Gels ; Irritants ; Male ; Microdialysis ; Nasal Mucosa ; Rats
Czasopismo naukowe
Tytuł :
Driving Impairment Cases Involving Etizolam and Flubromazolam.
Autorzy :
Rohrig TP; Sedgwick County Regional Forensic Science Center, 1109 N. Minneapolis, Wichita, KS 67214, USA.
Osawa KA; Sedgwick County Regional Forensic Science Center, 1109 N. Minneapolis, Wichita, KS 67214, USA.
Baird TR; Sedgwick County Regional Forensic Science Center, 1109 N. Minneapolis, Wichita, KS 67214, USA.
Youso KB; Sedgwick County Regional Forensic Science Center, 1109 N. Minneapolis, Wichita, KS 67214, USA.
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Źródło :
Journal of analytical toxicology [J Anal Toxicol] 2021 Feb 06; Vol. 45 (1), pp. 93-98.
Typ publikacji :
Journal Article
MeSH Terms :
Benzodiazepines/*metabolism
Diazepam/*analogs & derivatives
Driving Under the Influence/*statistics & numerical data
Tranquilizing Agents/*metabolism
Automobile Driving ; Diazepam/metabolism ; Humans ; Substance Abuse Detection
Czasopismo naukowe
Tytuł :
Toxicological outcome of exposure to psychoactive drugs carbamazepine and diazepam on non-target insect Nauphoeta cinerea.
Autorzy :
Adedara IA; Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address: .
Ajayi BO; Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Afolabi BA; Departamento de Bioquímica e Biologia Molecular, CCNE, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil.
Awogbindin IO; Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Rocha JBT; Departamento de Bioquímica e Biologia Molecular, CCNE, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil.
Farombi EO; Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
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Źródło :
Chemosphere [Chemosphere] 2021 Feb; Vol. 264 (Pt 1), pp. 128449. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Diazepam*/toxicity
Water Pollutants, Chemical*/toxicity
Animals ; Carbamazepine/toxicity ; Cockroaches ; Humans ; Lipid Peroxidation ; Psychotropic Drugs
Czasopismo naukowe
Tytuł :
Safety and tolerability associated with chronic intermittent use of diazepam buccal film in adult, adolescent, and pediatric patients with epilepsy.
Autorzy :
Seinfeld S; Joe DiMaggio Children's Hospital, Hollywood, FL, USA.
Gelfand MA; University of Pennsylvania, Philadelphia, PA, USA.
Heller AH; Pharma Study Design, Woodbridge, CT, USA.
Buan C; Aquestive Therapeutics, Inc., Warren, NJ, USA.
Slatko G; Aquestive Therapeutics, Inc., Warren, NJ, USA.
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Źródło :
Epilepsia [Epilepsia] 2020 Nov; Vol. 61 (11), pp. 2426-2434. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Anticonvulsants/*administration & dosage
Diazepam/*administration & dosage
Drug Delivery Systems/*methods
Epilepsy/*diagnosis
Epilepsy/*drug therapy
Administration, Buccal ; Adolescent ; Adult ; Aged ; Anticonvulsants/adverse effects ; Anticonvulsants/metabolism ; Child ; Child, Preschool ; Diazepam/adverse effects ; Diazepam/metabolism ; Drug Administration Schedule ; Epilepsy/metabolism ; Female ; Fever/chemically induced ; Humans ; Male ; Middle Aged ; Nausea/chemically induced ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors.
Autorzy :
Saleh NM; Department of Chemistry, Faculty of Science, Al-Azhar University (Girls Branch), PO Box 11754, Cairo, Egypt. Electronic address: .
El-Gaby MSA; Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Assiut 71524, Egypt.
El-Adl K; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11884, Cairo, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt. Electronic address: .
Abd El-Sattar NEA; Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104350. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Diazepam/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Sulfonamides/*pharmacology
Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Diazepam/chemical synthesis ; Diazepam/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship ; Sulfonamides/chemistry ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Czasopismo naukowe
Tytuł :
Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam.
Autorzy :
Hughes DA; Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor, Wales, UK.; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2020 Nov; Vol. 177 (21), pp. 4975-4989. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arrhythmias, Cardiac/*chemically induced
Cardiotoxicity/*etiology
Chloroquine/*poisoning
Diazepam/*pharmacology
Animals ; Arrhythmias, Cardiac/prevention & control ; Benzodiazepinones/pharmacology ; COVID-19 ; Cardiotoxicity/prevention & control ; Clonazepam/pharmacology ; Coronavirus Infections/drug therapy ; Diazepam/administration & dosage ; Dose-Response Relationship, Drug ; Drug Overdose ; Electrocardiography ; Female ; Hypokalemia/chemically induced ; Male ; Pandemics ; Pneumonia, Viral/drug therapy ; Rabbits ; Random Allocation ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Study on the Pharmacokinetics of Diazepam and Its Metabolites in Blood of Chinese People.
Autorzy :
Wang LL; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Ren XX; Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China.
He Y; Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China.
Cui GF; Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China.
Wei ZW; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Jia J; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Cao J; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Liu Y; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Cong B; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.; Department of Forensic Medicine, Hebei Medical University, Shijiazhuang, 050017, China.
Niu Y; Department of Criminal, The Ministry of Public Security, Beijing, 100038, China. .
Yun KM; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China. .
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Źródło :
European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2020 Aug; Vol. 45 (4), pp. 477-485.
Typ publikacji :
Journal Article
MeSH Terms :
Diazepam/*pharmacokinetics
Hypnotics and Sedatives/*pharmacokinetics
Administration, Oral ; Adult ; Asian Continental Ancestry Group ; China ; Chromatography, High Pressure Liquid ; Diazepam/administration & dosage ; Diazepam/blood ; Female ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/blood ; Male ; Metabolic Detoxication, Phase I ; Metabolic Detoxication, Phase II ; Models, Biological ; Solid Phase Extraction ; Tandem Mass Spectrometry ; Young Adult
Czasopismo naukowe
Tytuł :
Metabolic and psychiatric effects of acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI).
Autorzy :
Joseph A; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.; Faculté de Médecine, Université de Paris Saclay, Kremlin Bicetre, France.
Moriceau S; INSERM U1151, Institut Necker Enfants-Malades (INEM), Université Paris Descartes-Sorbonne-Paris Cité, Paris, France.
Sica V; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.; Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), Barcelona, Spain.
Anagnostopoulos G; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.; Faculté de Médecine, Université de Paris Saclay, Kremlin Bicetre, France.
Pol J; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.
Martins I; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.; Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.
Lafarge A; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.; Faculté de Médecine, Université de Paris Saclay, Kremlin Bicetre, France.
Maiuri MC; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.
Leboyer M; Fondation FondaMental, Créteil, France.; Université Paris Est Créteil, Inserm U955, IMRB, Laboratoire Neuro-Psychiatrie translationnelle, F-94010, Créteil, France.; AP-HP, HU Henri Mondor, Departement Medico-Universitaire de Psychiatrie et d'Addictologie (DMU ADAPT), Federation Hospitalo-Universitaire de Médecine de Precision (FHU IMPACT), F-94010, Créteil, France.; Fondation FondaMental Créteil, Créteil, France.
Loftus J; Fondation FondaMental, Créteil, France.; Pôle de Psychiatrie, Centre Hospitalier Princesse Grace, Monaco, France.
Bellivier F; Fondation FondaMental, Créteil, France.; AP-HP, GH Saint-Louis-Lariboisière-Fernand Widal, Pôle Neurosciences Tête et Cou, INSERM UMRS 1144, University Paris Diderot, Paris, France.
Belzeaux R; Fondation FondaMental, Créteil, France.; Pôle de Psychiatrie, Assistance Publique Hôpitaux de Marseille, Marseille, France.; INT-UMR7289, CNRS Aix-Marseille Université, Marseille, France.
Berna F; Fondation FondaMental, Créteil, France.; Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Etain B; Fondation FondaMental, Créteil, France.; AP-HP, GH Saint-Louis-Lariboisière-Fernand Widal, Pôle Neurosciences Tête et Cou, INSERM UMRS 1144, University Paris Diderot, Paris, France.
Capdevielle D; Fondation FondaMental, Créteil, France.; Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1, Inserm 1061, Montpellier, France.
Courtet P; Fondation FondaMental, Créteil, France.; Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, CHU Montpellier, Montpellier, France.; PSNREC, Univ Montpellier, INSERM, CHU Montpellier, Montpellier, France.
Dubertret C; Fondation FondaMental, Créteil, France.; AP-HP, Groupe Hospitalo-Universitaire Nord, DMU ESPRIT, Service de Psychiatrie et Addictologie. Hopital Louis Mourier, Colombes, Inserm U1266, Faculté de Médecine, Université de Paris, Paris, France.
Dubreucq J; Fondation FondaMental, Créteil, France.; Centre Référent de Réhabilitation Psychosociale et de Remédiation Cognitive (C3R), CH, Alpes Isère, France.
Thierry A; Fondation FondaMental, Créteil, France.; INSERM U1028, CNRS UMR5292, Centre de Recherche en Neurosciences de Lyon, Université Claude Bernard Lyon 1, Equipe PSYR2, Centre Hospitalier Le Vinatier, Pole Est, 69678, Bron Cedex, France.
Fond G; Fondation FondaMental, Créteil, France.; AP-HM, Aix-Marseille University, School of Medicine-La Timone Medical Campus, EA 3279, Marseille, France.; EReSS-Health Service Research and Quality of Life Center, 13005, Marseille, France.
Gard S; Fondation FondaMental, Créteil, France.; Centre Expert Troubles Bipolaires, Service de Psychiatrie Adulte, Hôpital Charles-Perrens, Bordeaux, France.
Llorca PM; Fondation FondaMental, Créteil, France.; CHU Clermont-Ferrand, Department of Psychiatry, University of Clermont Auvergne, Clermont-Ferrand, France.
Mallet J; Fondation FondaMental, Créteil, France.; AP-HP, Groupe Hospitalo-Universitaire Nord, DMU ESPRIT, Service de Psychiatrie et Addictologie. Hopital Louis Mourier, Colombes, Inserm U1266, Faculté de Médecine, Université de Paris, Paris, France.
Misdrahi D; Fondation FondaMental, Créteil, France.; Centre Expert Troubles Bipolaires, Service de Psychiatrie Adulte, Hôpital Charles-Perrens, Bordeaux, France.
Olié E; Fondation FondaMental, Créteil, France.; Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, CHU Montpellier, Montpellier, France.
Passerieux C; Fondation FondaMental, Créteil, France.; Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, Le Chesnay, Université Paris-Saclay, UVSQ, Inserm, CESP, Team 'DevPsy', 94807, Villejuif, France.
Polosan M; Fondation FondaMental, Créteil, France.; Université Grenoble Alpes, CHU de Grenoble et des Alpes, Grenoble Institut des Neurosciences (GIN) Inserm U 1216, Grenoble, France.
Roux P; Fondation FondaMental, Créteil, France.; Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, Le Chesnay, Université Paris-Saclay, UVSQ, Inserm, CESP, Team 'DevPsy', 94807, Villejuif, France.
Samalin L; Fondation FondaMental, Créteil, France.; CHU Clermont-Ferrand, Department of Psychiatry, University of Clermont Auvergne, Clermont-Ferrand, France.
Schürhoff F; Fondation FondaMental, Créteil, France.; Université Paris Est Créteil, Inserm U955, IMRB, Laboratoire Neuro-Psychiatrie translationnelle, F-94010, Créteil, France.; AP-HP, HU Henri Mondor, Departement Medico-Universitaire de Psychiatrie et d'Addictologie (DMU ADAPT), Federation Hospitalo-Universitaire de Médecine de Precision (FHU IMPACT), F-94010, Créteil, France.; Fondation FondaMental Créteil, Créteil, France.
Schwan R; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France.; Université de Lorraine, CHRU de Nancy et Pôle de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy, Nancy, France.
Magnan C; Université de Paris, BFA, UMR 8251, CNRS, Paris, France.
Oury F; INSERM U1151, Institut Necker Enfants-Malades (INEM), Université Paris Descartes-Sorbonne-Paris Cité, Paris, France.
Bravo-San Pedro JM; University Complutense of Madrid. Faculty of Medicine. Department of Physiology, Madrid, Spain. .
Kroemer G; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France. .; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France. .; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France. .; Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China. .; Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden. .
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Corporate Authors :
FACE-SZ and FACE-BD (FondaMental Academic Centers of Expertise, for Schizophrenia and for Bipolar Disorder) Groups
Źródło :
Cell death & disease [Cell Death Dis] 2020 Jul 06; Vol. 11 (7), pp. 502. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diazepam Binding Inhibitor/*metabolism
Mental Disorders/*metabolism
Animals ; Appetite ; Behavior, Animal ; Body Mass Index ; Darkness ; Diazepam Binding Inhibitor/blood ; Feeding Behavior ; Immobilization ; Male ; Mental Disorders/blood ; Mental Disorders/diagnosis ; Metabolic Syndrome/blood ; Mice, Inbred C57BL ; Receptors, GABA-A/metabolism ; Swimming/physiology
Czasopismo naukowe
Tytuł :
Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study.
Autorzy :
Hogan RE; Washington University in St Louis, St Louis, Missouri.
Tarquinio D; Center for Rare Neurological Diseases, Atlanta, Georgia.
Sperling MR; Thomas Jefferson University, Philadelphia, Pennsylvania.
Klein P; Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland.
Miller I; Nicklaus Children's Hospital, Miami, Florida.
Segal EB; Hackensack University Medical Center, Hackensack Meridian School of Medicine and Northeast Regional Epilepsy Group, Hackensack, New Jersey.
Rabinowicz AL; Neurelis, San Diego, California.
Carrazana E; Consultant for Neurelis, San Diego, California.
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Źródło :
Epilepsia [Epilepsia] 2020 May; Vol. 61 (5), pp. 935-943. Date of Electronic Publication: 2020 Apr 27.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diazepam/*therapeutic use
Epilepsy/*drug therapy
Seizures/*drug therapy
Administration, Intranasal ; Adolescent ; Adult ; Aged ; Child ; Diazepam/administration & dosage ; Diazepam/adverse effects ; Diazepam/pharmacokinetics ; Female ; Humans ; Male ; Middle Aged ; Nasal Sprays ; Young Adult
Czasopismo naukowe
Tytuł :
Diazepam's antifungal activity in fluconazole-resistant Candida spp. and biofilm inhibition in C. albicans : evaluation of the relationship with the proteins ALS3 and SAP5.
Autorzy :
Juvêncio da Silva L; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Dias Barroso FD; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Vieira LS; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
Carlos Mota DR; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
da Silva Firmino BK; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
Rocha da Silva C; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
de Farias Cabral VP; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Cândido TM; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Sá LGDAV; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Barbosa da Silva WM; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
Silva J; Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, Limoeiro do Norte, Ceará, Brazil.
Marinho ES; Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, Limoeiro do Norte, Ceará, Brazil.
Cavalcanti BC; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
de Moraes MO; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
Júnior HVN; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
de Andrade Neto JB; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
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Źródło :
Journal of medical microbiology [J Med Microbiol] 2021 Mar; Vol. 70 (3). Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antifungal Agents/*pharmacology
Biofilms/*drug effects
Candida/*drug effects
Diazepam/*pharmacology
Drug Resistance, Fungal/*drug effects
Aspartic Acid Endopeptidases/metabolism ; Candida/pathogenicity ; Fluconazole/pharmacology ; Fungal Proteins/metabolism
Czasopismo naukowe
Tytuł :
Utility of Hypertonic Saline and Diazepam in COVID-19-Related Hydroxychloroquine Toxicity.
Autorzy :
Mahan KM; Harvard Medical School, Boston, Massachusetts; Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Hayes BD; Harvard Medical School, Boston, Massachusetts; Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Pharmacy, Massachusetts General Hospital, Boston, Massachusetts.
North CM; Harvard Medical School, Boston, Massachusetts; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Becker JS; Harvard Medical School, Boston, Massachusetts; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Fenves AZ; Harvard Medical School, Boston, Massachusetts; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Hyppolite G; Harvard Medical School, Boston, Massachusetts; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Khosrowjerdi S; Harvard Medical School, Boston, Massachusetts; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Sinden D; Harvard Medical School, Boston, Massachusetts; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Stearns DA; Harvard Medical School, Boston, Massachusetts; Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts.
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Źródło :
The Journal of emergency medicine [J Emerg Med] 2021 Mar; Vol. 60 (3), pp. 359-364. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
COVID-19/*drug therapy
Diazepam/*therapeutic use
Heart Block/*chemically induced
Hydroxychloroquine/*poisoning
Hypnotics and Sedatives/*therapeutic use
Long QT Syndrome/*chemically induced
Poisoning/*therapy
Saline Solution, Hypertonic/*therapeutic use
Adult ; Electrocardiography ; Emergency Service, Hospital ; Heart Block/therapy ; Humans ; Long QT Syndrome/therapy ; Male ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Diazepam in the Elderly: Looking Back, Ahead, and at the Evidence.
Autorzy :
Greenblatt DJ; From Tufts University School of Medicine, Boston, MA.
Harmatz JS
Shader RI
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Źródło :
Journal of clinical psychopharmacology [J Clin Psychopharmacol] 2020 May/Jun; Vol. 40 (3), pp. 215-219.
Typ publikacji :
Editorial
MeSH Terms :
Central Nervous System Sensitization*
Anxiety Disorders/*drug therapy
Diazepam/*adverse effects
Diazepam/*therapeutic use
Aged ; Aged, 80 and over ; Diazepam/pharmacokinetics ; Female ; Forecasting ; Humans ; Male
Opinia redakcyjna
Tytuł :
Subregion-Specific Impacts of Genetic Loss of Diazepam Binding Inhibitor on Synaptic Inhibition in the Murine Hippocampus.
Autorzy :
Courtney CD; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Christian CA; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, United States; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, United States; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2018 Sep 15; Vol. 388, pp. 128-138. Date of Electronic Publication: 2018 Jul 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diazepam Binding Inhibitor/*deficiency
Hippocampus/*metabolism
Inhibitory Postsynaptic Potentials/*physiology
Neurons/*metabolism
Animals ; Central Nervous System Agents/pharmacology ; Diazepam/pharmacology ; Diazepam Binding Inhibitor/antagonists & inhibitors ; Diazepam Binding Inhibitor/genetics ; Female ; Flumazenil/pharmacology ; Hippocampus/drug effects ; Inhibitory Postsynaptic Potentials/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Miniature Postsynaptic Potentials/drug effects ; Miniature Postsynaptic Potentials/physiology ; Neurons/drug effects ; Receptors, GABA-A/metabolism ; Tissue Culture Techniques
Czasopismo naukowe
Tytuł :
Gut microbiota-derived indole 3-propionic acid protects against radiation toxicity via retaining acyl-CoA-binding protein.
Autorzy :
Xiao HW; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, Tianjin, 300192, China.
Cui M; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, Tianjin, 300192, China. .
Li Y; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, Tianjin, 300192, China.
Dong JL; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, Tianjin, 300192, China.
Zhang SQ; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, Tianjin, 300192, China.
Zhu CC; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, Tianjin, 300192, China.
Jiang M; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, Tianjin, 300192, China.
Zhu T; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, Tianjin, 300192, China.
Wang B; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, Tianjin, 300192, China.
Wang HC; Laboratory of Emergency Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA.
Fan SJ; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, Tianjin, 300192, China. .
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Źródło :
Microbiome [Microbiome] 2020 May 20; Vol. 8 (1), pp. 69. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Diazepam Binding Inhibitor*/metabolism
Fecal Microbiota Transplantation*
Gastrointestinal Microbiome*/drug effects
Gastrointestinal Microbiome*/radiation effects
Indoles*/administration & dosage
Indoles*/pharmacology
Radiation Injuries*/therapy
Animals ; Cell Line ; Feces/chemistry ; Female ; Gastrointestinal Tract/drug effects ; Gastrointestinal Tract/microbiology ; Hematopoiesis/drug effects ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Nude ; Pregnane X Receptor/metabolism ; RNA, Ribosomal, 16S/genetics ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets.
Autorzy :
Taliani S; Department of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.
Da Settimo F; Department of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.
Martini C; Department of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.
Laneri S; Department of Pharmacy, University of Naples 'Federico II', Via D. Montesano, 49, 80131 Naples, Italy.
Novellino E; Department of Pharmacy, University of Naples 'Federico II', Via D. Montesano, 49, 80131 Naples, Italy.
Greco G; Department of Pharmacy, University of Naples 'Federico II', Via D. Montesano, 49, 80131 Naples, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 May 16; Vol. 25 (10). Date of Electronic Publication: 2020 May 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Design*
Diazepam/*analogs & derivatives
GABA Modulators/*chemical synthesis
Indoles/*chemical synthesis
Receptors, GABA-A/*metabolism
Animals ; Diazepam/pharmacology ; GABA Modulators/pharmacology ; Humans ; Indoles/pharmacology ; Kelch-Like ECH-Associated Protein 1/agonists ; Kelch-Like ECH-Associated Protein 1/antagonists & inhibitors ; Kelch-Like ECH-Associated Protein 1/metabolism ; Ligands ; Mice ; Protein Binding ; Proto-Oncogene Proteins c-mdm2/antagonists & inhibitors ; Proto-Oncogene Proteins c-mdm2/chemistry ; Proto-Oncogene Proteins c-mdm2/metabolism ; Receptor, Adenosine A2B/chemistry ; Receptor, Adenosine A2B/metabolism ; Receptors, GABA/chemistry ; Receptors, GABA/metabolism ; Receptors, GABA-A/chemistry ; Structure-Activity Relationship
Czasopismo naukowe

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