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Tytuł:
RNA-based analysis of ALK fusions in non-small cell lung cancer cases showing IHC/FISH discordance.
Autorzy:
Vollbrecht C; Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Charitéplatz 1, 10117, Berlin, Germany. .; German Cancer Consortium (DKTK), partner site Berlin, Germany. .; Geman Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. .
Lenze D; Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Charitéplatz 1, 10117, Berlin, Germany.
Hummel M; Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Charitéplatz 1, 10117, Berlin, Germany.; German Cancer Consortium (DKTK), partner site Berlin, Germany.
Lehmann A; Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Charitéplatz 1, 10117, Berlin, Germany.
Moebs M; Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Charitéplatz 1, 10117, Berlin, Germany.
Frost N; Medical Department, Division of Infectiology and Pneumology, Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany.
Jurmeister P; Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Charitéplatz 1, 10117, Berlin, Germany.; Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charité Comprehensive Cancer Center, Virchowweg 23, 10117, Berlin, Germany.
Schweizer L; Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Charitéplatz 1, 10117, Berlin, Germany.
Kellner U; Johannes Wesling Klinikum Minden, Institute for Pathology, Hans-Nolte-Straße 1, 32429, Minden, Germany.
Dietel M; Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Charitéplatz 1, 10117, Berlin, Germany.
von Laffert M; Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Charitéplatz 1, 10117, Berlin, Germany. .; Berlin Institute of Health (BIH), Anna-Louisa-Karsch-Straße 2, 10178, Berlin, Germany. .
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Źródło:
BMC cancer [BMC Cancer] 2018 Nov 22; Vol. 18 (1), pp. 1158. Date of Electronic Publication: 2018 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
Anaplastic Lymphoma Kinase/*genetics
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Oncogene Proteins, Fusion/*genetics
Anaplastic Lymphoma Kinase/metabolism ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Gene Expression Profiling ; Gene Rearrangement ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Oncogene Proteins, Fusion/metabolism ; Sensitivity and Specificity ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Treatment decisions, clinical outcomes, and pharmacoeconomics in the treatment of patients with EGFR mutated stage III/IV NSCLC in Germany: an observational study.
Autorzy:
Schuette W; Krankenhaus Martha-Maria Halle-Doelau gGmbH, Klinik für Innere Medizin II, Roentgenstr, 106120, Halle, Germany. .
Schirmacher P; Pathologisches Institut, Universitätklinik Heidelberg, Heidelberg, Germany.
Eberhardt WEE; Department of Medical Oncology, West German Tumor Centre, University Hospital Essen, Rurhlandlkinik, University Duisburg-Essen, Essen, Germany.
Dietel M; Pathologisches Institut Humboldt, Universität Berlin, Berlin, Germany.
Zirrgiebel U; iOMEDICO AG, Freiburg, Germany.
Muehlenhoff L; Medical Affairs, AstraZeneca, Wedel, Germany.
Thomas M; Internistische Onkologie der Thoraxtumoren, Thoraxklinik im Universitätsklinikum Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research, Heidelberg, Germany.
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Źródło:
BMC cancer [BMC Cancer] 2018 Feb 05; Vol. 18 (1), pp. 135. Date of Electronic Publication: 2018 Feb 05.
Typ publikacji:
Clinical Trial; Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*drug therapy
ErbB Receptors/*genetics
Lung Neoplasms/*drug therapy
Quinazolines/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Diarrhea/chemically induced ; Disease-Free Survival ; Economics, Pharmaceutical ; Exanthema/chemically induced ; Female ; Gefitinib ; Germany ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Mutation ; Neoplasm Staging ; Outcome Assessment, Health Care/economics ; Outcome Assessment, Health Care/methods ; Prospective Studies ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Quinazolines/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interlaboratory concordance of PD-L1 immunohistochemistry for non-small-cell lung cancer.
Autorzy:
Scheel AH; Institute of Pathology, University Hospital Cologne, Cologne, Germany.
Baenfer G; Targos Molecular Pathology GmbH, Kassel, Germany.
Baretton G; Institute of Pathology, University Hospital Dresden, Dresden, Germany.
Dietel M; Institute of Pathology, Charité-University Hospital Berlin, Berlin, Germany.
Diezko R; Targos Molecular Pathology GmbH, Kassel, Germany.
Henkel T; Targos Molecular Pathology GmbH, Kassel, Germany.
Heukamp LC; Institute for Haematopathology Hamburg, Hamburg, Germany.
Jasani B; Targos Molecular Pathology GmbH, Kassel, Germany.
Jöhrens K; Institute of Pathology, Charité-University Hospital Berlin, Berlin, Germany.
Kirchner T; Institute of Pathology, LMU University Hospital Munich, Munich, Germany.
Lasitschka F; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Petersen I; Institute of Pathology, University Hospital Jena, Jena, Germany.
Reu S; Institute of Pathology, LMU University Hospital Munich, Munich, Germany.
Schildhaus HU; Institute of Pathology, University Hospital Göttingen, Göttingen, Germany.
Schirmacher P; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Schwamborn K; Institute of Pathology, TUM University Hospital Munich, Munich, Germany.
Sommer U; Institute of Pathology, University Hospital Dresden, Dresden, Germany.
Stoss O; Targos Molecular Pathology GmbH, Kassel, Germany.
Tiemann M; Institute for Haematopathology Hamburg, Hamburg, Germany.
Warth A; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Weichert W; Institute of Pathology, TUM University Hospital Munich, Munich, Germany.
Wolf J; Medical Clinic I, University Hospital Cologne, Cologne, Germany.
Büttner R; Institute of Pathology, University Hospital Cologne, Cologne, Germany.; Targos Molecular Pathology GmbH, Kassel, Germany.
Rüschoff J; Targos Molecular Pathology GmbH, Kassel, Germany.; Institute of Pathology Nordhessen, Kassel, Germany.
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Źródło:
Histopathology [Histopathology] 2018 Feb; Vol. 72 (3), pp. 449-459. Date of Electronic Publication: 2017 Nov 21.
Typ publikacji:
Journal Article; Multicenter Study
MeSH Terms:
B7-H1 Antigen/*analysis
Biomarkers, Tumor/*analysis
Carcinoma, Non-Small-Cell Lung/*diagnosis
Immunohistochemistry/*standards
Lung Neoplasms/*diagnosis
Humans ; Reproducibility of Results
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sensitivity of HOXB13 as a Diagnostic Immunohistochemical Marker of Prostatic Origin in Prostate Cancer Metastases: Comparison to PSA, Prostein, Androgen Receptor, ERG, NKX3.1, PSAP, and PSMA.
Autorzy:
Kristiansen I; Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany. .
Stephan C; Department of Urology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany. .
Jung K; Berlin Institute of Urologic Research, Berlin, Germany. .
Dietel M; Institute of Pathology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany. .
Rieger A; Institute of Pathology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany. Manfred.dietel@charite.de.
Tolkach Y; Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany. .
Kristiansen G; Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2017 May 29; Vol. 18 (6). Date of Electronic Publication: 2017 May 29.
Typ publikacji:
Journal Article
MeSH Terms:
Antigens, Surface/*metabolism
Biomarkers, Tumor/*metabolism
Glutamate Carboxypeptidase II/*metabolism
Homeodomain Proteins/*metabolism
Immunohistochemistry/*methods
Membrane Proteins/*metabolism
Prostatic Neoplasms/*metabolism
Receptors, Androgen/*metabolism
Transcription Factors/*metabolism
Antigens, Surface/genetics ; Biomarkers, Tumor/genetics ; Glutamate Carboxypeptidase II/genetics ; Homeodomain Proteins/genetics ; Humans ; Male ; Membrane Proteins/genetics ; Prostate-Specific Antigen/metabolism ; Prostatic Neoplasms/genetics ; Receptors, Androgen/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Increase of T and B cells and altered BACH2 expression patterns in bone marrow trephines of imatinib-treated patients with chronic myelogenous leukaemia.
Autorzy:
Von Laffert M; Institute of Pathology, Charité Universitätsmedizin, D-10117 Berlin, Germany.
Hänel M; Department of Internal Medicine III, Klinikum Chemnitz gGmbH, D-09113 Chemnitz, Germany.
Dietel M; Institute of Pathology, Charité Universitätsmedizin, D-10117 Berlin, Germany.
Anagnostopoulos I; Institute of Pathology, Charité Universitätsmedizin, D-10117 Berlin, Germany.
Jöhrens K; Institute of Pathology, Charité Universitätsmedizin, D-10117 Berlin, Germany.
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Źródło:
Oncology letters [Oncol Lett] 2016 Oct; Vol. 12 (4), pp. 2421-2428. Date of Electronic Publication: 2016 Aug 05.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Molecular Pathology: A Requirement for Precision Medicine in Cancer.
Autorzy:
Dietel M; Institute of Pathology, Charité, University Medicine Berlin, Berlin, Germany.
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Źródło:
Oncology research and treatment [Oncol Res Treat] 2016; Vol. 39 (12), pp. 804-810. Date of Electronic Publication: 2016 Nov 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Biomarkers, Tumor/*genetics
Genetic Testing/*trends
Molecular Diagnostic Techniques/*trends
Neoplasms/*diagnosis
Neoplasms/*therapy
Precision Medicine/*trends
Antineoplastic Agents/therapeutic use ; Evidence-Based Medicine ; Humans ; Neoplasms/genetics ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cancer-testis antigen cyclin A1 is broadly expressed in ovarian cancer and is associated with prolonged time to tumor progression after platinum-based therapy.
Autorzy:
Arsenic R; Department of Pathology, Institute of Pathology, Charité - University Hospital Berlin, 10117, Berlin, Germany. .
Braicu EI; Departement of Gynecology, University Hospital Berlin, 13353, Berlin, Germany. .
Letsch A; Department of Hematology, Oncology and Tumor Immunology - University Hospital Berlin, 12200, Berlin, Germany. .
Dietel M; Department of Pathology, Institute of Pathology, Charité - University Hospital Berlin, 10117, Berlin, Germany. manfred.dietel@charite.de.
Sehouli J; Departement of Gynecology, University Hospital Berlin, 13353, Berlin, Germany. .
Keilholz U; Charité Cancer Comprehensive Center, Charité, 10117, Berlin, Germany. .
Ochsenreither S; Department of Hematology, Oncology and Tumor Immunology - University Hospital Berlin, 12200, Berlin, Germany. .
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Źródło:
BMC cancer [BMC Cancer] 2015 Oct 24; Vol. 15, pp. 784. Date of Electronic Publication: 2015 Oct 24.
Typ publikacji:
Journal Article
MeSH Terms:
Biomarkers, Tumor/*metabolism
Cyclin A1/*metabolism
Ovarian Neoplasms/*metabolism
RNA, Messenger/*metabolism
Adult ; Aged ; Antineoplastic Agents/therapeutic use ; Carboplatin/therapeutic use ; Disease Progression ; Female ; Humans ; Immunohistochemistry ; Microarray Analysis ; Middle Aged ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology ; Paclitaxel/therapeutic use ; Real-Time Polymerase Chain Reaction ; Survival Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Glutathione S-transferase-pi protein expression in prostate cancer--not always a useful diagnostic tool.
Autorzy:
Sailer V; Institute of Pathology, University of Bonn, Bonn, Germany.
Eberhard HL; Institute of Surgical Pathology, UniversitätsSpital Zürich, Zurich, Switzerland.
Stephan C; Department of Urology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Institute for Urologic Research, Berlin, Germany.
Wernert N; Institute of Pathology, University of Bonn, Bonn, Germany.
Perner S; Institute of Pathology, University of Bonn, Bonn, Germany.
Jung K; Department of Urology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Institute for Urologic Research, Berlin, Germany.
Dietel M; Institute of Pathology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Bubendorf L; Institute of Pathology, University Hospital Basel, Basel, Switzerland.
Kristiansen G; Institute of Pathology, University of Bonn, Bonn, Germany.
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Źródło:
Histopathology [Histopathology] 2015 Oct; Vol. 67 (4), pp. 577-9. Date of Electronic Publication: 2015 Apr 09.
Typ publikacji:
Letter
MeSH Terms:
Biomarkers, Tumor/*analysis
Glutathione S-Transferase pi/*biosynthesis
Prostatic Intraepithelial Neoplasia/*diagnosis
Prostatic Neoplasms/*diagnosis
Glutathione S-Transferase pi/analysis ; Humans ; Immunohistochemistry ; Male ; Prostatic Intraepithelial Neoplasia/enzymology ; Prostatic Neoplasms/enzymology ; Tissue Array Analysis
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prospective validation of immunological infiltrate for prediction of response to neoadjuvant chemotherapy in HER2-negative breast cancer--a substudy of the neoadjuvant GeparQuinto trial.
Autorzy:
Issa-Nummer Y; German Breast Group, Neu-Isenburg, Germany.
Darb-Esfahani S
Loibl S
Kunz G
Nekljudova V
Schrader I
Sinn BV
Ulmer HU
Kronenwett R
Just M
Kühn T
Diebold K
Untch M
Holms F
Blohmer JU
Habeck JO
Dietel M
Overkamp F
Krabisch P
von Minckwitz G
Denkert C
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Źródło:
PloS one [PLoS One] 2013 Dec 02; Vol. 8 (12), pp. e79775. Date of Electronic Publication: 2013 Dec 02 (Print Publication: 2013).
Typ publikacji:
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms*/drug therapy
Breast Neoplasms*/immunology
Breast Neoplasms*/mortality
Breast Neoplasms*/pathology
Lymphocytes*/immunology
Lymphocytes*/pathology
Neoadjuvant Therapy*
Receptor, ErbB-2*
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Adult ; Aged ; Anthracyclines/administration & dosage ; Bridged-Ring Compounds/administration & dosage ; Female ; Humans ; Middle Aged ; Prospective Studies ; Taxoids/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Comparison of p40 (ΔNp63) and p63 expression in prostate tissues--which one is the superior diagnostic marker for basal cells?
Autorzy:
Sailer V; Institute of Pathology, University Hospital of Bonn, Bonn, Germany.
Stephan C
Wernert N
Perner S
Jung K
Dietel M
Kristiansen G
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Źródło:
Histopathology [Histopathology] 2013 Jul; Vol. 63 (1), pp. 50-6. Date of Electronic Publication: 2013 May 13.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Prostate/*metabolism
Prostatic Neoplasms/*metabolism
Transcription Factors/*metabolism
Tumor Suppressor Proteins/*metabolism
Cohort Studies ; Humans ; Male ; Prostate/pathology ; Prostatectomy ; Prostatic Neoplasms/pathology ; Protein Isoforms/metabolism ; Tissue Array Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The EndoPredict Gene-Expression Assay in Clinical Practice - Performance and Impact on Clinical Decisions.
Autorzy:
Müller BM; Institute of Pathology, Charité University Hospital, Campus Mitte, Berlin, Germany.
Keil E
Lehmann A
Winzer KJ
Richter-Ehrenstein C
Prinzler J
Bangemann N
Reles A
Stadie S
Schoenegg W
Eucker J
Schmidt M
Lippek F
Jöhrens K
Pahl S
Sinn BV
Budczies J
Dietel M
Denkert C
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Źródło:
PloS one [PLoS One] 2013 Jun 27; Vol. 8 (6), pp. e68252. Date of Electronic Publication: 2013 Jun 27 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Clinical Decision-Making*
Gene Expression Profiling*/instrumentation
Breast Neoplasms/*diagnosis
Breast Neoplasms/*metabolism
Adult ; Aged ; Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/drug therapy ; Female ; Humans ; Middle Aged ; Receptors, Estrogen/metabolism ; Retrospective Studies ; Risk Assessment ; Surveys and Questionnaires
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer--overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression.
Autorzy:
Müller BM; Institute of Pathology, Charité University Hospital, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany. />Jana L
Kasajima A
Lehmann A
Prinzler J
Budczies J
Winzer KJ
Dietel M
Weichert W
Denkert C
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Źródło:
BMC cancer [BMC Cancer] 2013 Apr 30; Vol. 13, pp. 215. Date of Electronic Publication: 2013 Apr 30.
Typ publikacji:
Journal Article
MeSH Terms:
Disease Progression*
Breast Neoplasms/*enzymology
Breast Neoplasms/*pathology
Carcinoma, Ductal, Breast/*enzymology
Carcinoma, Lobular/*enzymology
Histone Deacetylases/*metabolism
Carcinoma, Ductal, Breast/secondary ; Carcinoma, Lobular/secondary ; Female ; Histone Deacetylase 1/metabolism ; Histone Deacetylase 2/metabolism ; Humans ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Grading ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Tissue Array Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
CognitionMaster: an object-based image analysis framework.
Autorzy:
Wienert S; Institute of Pathology, Charité University Hospital Berlin, Charitéplatz 1, Berlin, 10117, Germany. />Heim D
Kotani M
Lindequist B
Stenzinger A
Ishii M
Hufnagl P
Beil M
Dietel M
Denkert C
Klauschen F
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Źródło:
Diagnostic pathology [Diagn Pathol] 2013 Feb 27; Vol. 8, pp. 34. Date of Electronic Publication: 2013 Feb 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Software*
Bone and Bones/*pathology
Breast Neoplasms/*pathology
Image Interpretation, Computer-Assisted/*methods
Immunohistochemistry/*methods
Microscopy, Fluorescence, Multiphoton/*methods
Osteoclasts/*pathology
Algorithms ; Automation, Laboratory ; Breast Neoplasms/chemistry ; Cell Communication ; Cell Proliferation ; Female ; Humans ; Ki-67 Antigen/analysis ; Predictive Value of Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Decentral gene expression analysis: analytical validation of the Endopredict genomic multianalyte breast cancer prognosis test.
Autorzy:
Kronenwett R; Sividon Diagnostics GmbH, Nattermannallee 1, 50829, Cologne, Germany. />Bohmann K
Prinzler J
Sinn BV
Haufe F
Roth C
Averdick M
Ropers T
Windbergs C
Brase JC
Weber KE
Fisch K
Müller BM
Schmidt M
Filipits M
Dubsky P
Petry C
Dietel M
Denkert C
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Źródło:
BMC cancer [BMC Cancer] 2012 Oct 05; Vol. 12, pp. 456. Date of Electronic Publication: 2012 Oct 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms:
Breast Neoplasms/*genetics
Gene Expression Profiling/*methods
Pathology, Molecular/*methods
RNA/*analysis
Breast Neoplasms/pathology ; Female ; Humans ; Prognosis ; Real-Time Polymerase Chain Reaction ; Reproducibility of Results ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer.
Autorzy:
Faggad A; Institute of Pathology, Charité University Hospital, Berlin, GermanyDepartment of Molecular Biology, National Cancer Institute, University of Gezira, Wad Medani, SudanInstitute of Pathology, University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Kasajima A
Weichert W
Stenzinger A
Elwali NE
Dietel M
Denkert C
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Źródło:
Histopathology [Histopathology] 2012 Oct; Vol. 61 (4), pp. 552-61.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers, Tumor/*analysis
Colorectal Neoplasms/*pathology
DEAD-box RNA Helicases/*biosynthesis
Ribonuclease III/*biosynthesis
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/mortality ; DEAD-box RNA Helicases/analysis ; Disease-Free Survival ; Down-Regulation ; Female ; Humans ; Immunoblotting ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; MicroRNAs/metabolism ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Ribonuclease III/analysis ; Tissue Array Analysis ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer.
Autorzy:
Klauschen F; Institute of Pathology, Charité University Medicine Berlin, Germany. />von Winterfeld M
Stenzinger A
Sinn BV
Budczies J
Kamphues C
Bahra M
Wittschieber D
Weichert W
Striefler J
Riess H
Dietel M
Denkert C
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Źródło:
Histopathology [Histopathology] 2012 Sep; Vol. 61 (3), pp. 409-16. Date of Electronic Publication: 2012 Mar 02.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma/*enzymology
Adenocarcinoma/*mortality
Pancreatic Neoplasms/*enzymology
Pancreatic Neoplasms/*mortality
Poly(ADP-ribose) Polymerases/*biosynthesis
Aged ; Biomarkers, Tumor/analysis ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Tissue Array Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue - a GC-TOFMS based metabolomics study.
Autorzy:
Budczies J; Institute of Pathology, Charité University Hospital, 10117 Berlin, Germany. />Denkert C
Müller BM
Brockmöller SF
Klauschen F
Györffy B
Dietel M
Richter-Ehrenstein C
Marten U
Salek RM
Griffin JL
Hilvo M
Orešič M
Wohlgemuth G
Fiehn O
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Źródło:
BMC genomics [BMC Genomics] 2012 Jul 23; Vol. 13, pp. 334. Date of Electronic Publication: 2012 Jul 23.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast/*cytology
Breast/*metabolism
Breast Neoplasms/*metabolism
Breast Neoplasms/*pathology
Gas Chromatography-Mass Spectrometry/*methods
Metabolomics/*methods
Amino Acids/metabolism ; Breast/pathology ; Cluster Analysis ; Energy Metabolism ; Fatty Acids, Nonesterified/metabolism ; Female ; Glycerophospholipids/metabolism ; Humans ; Neoplasm Invasiveness ; Nucleotides/metabolism ; Principal Component Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer.
Autorzy:
Kamphues C; Department of General, Visceral and Transplantation Surgery, Charité University Hospital, Berlin, Germany. />Wittschieber D
Klauschen F
Kasajima A
Dietel M
Schmidt SC
Glanemann M
Bahra M
Neuhaus P
Weichert W
Stenzinger A
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Źródło:
Pathobiology : journal of immunopathology, molecular and cellular biology [Pathobiology] 2012; Vol. 79 (1), pp. 11-7. Date of Electronic Publication: 2012 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma/*metabolism
Adenocarcinoma/*pathology
Biomarkers, Tumor/*metabolism
Procollagen-Proline Dioxygenase/*metabolism
Stomach Neoplasms/*metabolism
Stomach Neoplasms/*pathology
Adenocarcinoma/mortality ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Hypoxia-Inducible Factor-Proline Dioxygenases ; Male ; Middle Aged ; Prognosis ; Stomach Neoplasms/mortality ; Survival Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Who is at risk for diagnostic discrepancies? Comparison of pre- and postmortal diagnoses in 1800 patients of 3 medical decades in East and West Berlin.
Autorzy:
Wittschieber D; Institute of Pathology, Charité University Hospital, Berlin, Germany.
Klauschen F
Kimmritz AC
von Winterfeld M
Kamphues C
Scholman HJ
Erbersdobler A
Pfeiffer H
Denkert C
Dietel M
Weichert W
Budczies J
Stenzinger A
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (5), pp. e37460. Date of Electronic Publication: 2012 May 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cause of Death*
Diagnostic Errors*
Autopsy ; Female ; Germany ; Humans ; Male ; Retrospective Studies ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Three different expression patterns of T-bet in angioimmunoblastic T-cell lymphoma.
Autorzy:
Jöhrens K; Institute of Pathology, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany. />Dietel M
Anagnostopoulos I
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2012 Jan; Vol. 53 (1), pp. 152-5. Date of Electronic Publication: 2011 Sep 19.
Typ publikacji:
Journal Article
MeSH Terms:
B-Lymphocytes/*metabolism
Immunoblastic Lymphadenopathy/*metabolism
Lymphoma, T-Cell/*metabolism
T-Box Domain Proteins/*biosynthesis
Antigens, CD20/biosynthesis ; B-Lymphocytes/pathology ; CD3 Complex/biosynthesis ; Epstein-Barr Virus Infections/metabolism ; Epstein-Barr Virus Infections/virology ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/physiology ; Host-Pathogen Interactions ; Humans ; Immunoblastic Lymphadenopathy/pathology ; Immunoblastic Lymphadenopathy/virology ; Immunohistochemistry ; In Situ Hybridization ; Lymphoma, T-Cell/pathology ; Lymphoma, T-Cell/virology ; RNA, Viral/genetics
Czasopismo naukowe
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