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Tytuł :
Reduced expression levels of heat shock protein 90 in a diminazene aceturate-resistant Babesia gibsoni isolate.
Autorzy :
Yamasaki M; Laboratory of Veterinary Small Animal Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 202-8550, Japan. Electronic address: .
Idaka N; Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
Abe M; Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
Takiguchi M; Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
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Źródło :
Experimental parasitology [Exp Parasitol] 2021 Feb; Vol. 221, pp. 108050. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antiprotozoal Agents/*pharmacology
Babesia/*drug effects
Babesia/*metabolism
Diminazene/*analogs & derivatives
HSP90 Heat-Shock Proteins/*metabolism
Animals ; Blotting, Western ; Diminazene/pharmacology ; Dogs ; Drug Resistance ; Electrophoresis, Polyacrylamide Gel ; Erythrocytes/chemistry ; Erythrocytes/parasitology ; Fluorescent Antibody Technique, Indirect ; Immunoblotting ; Potassium/metabolism ; Rabbits ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats.
Autorzy :
Silva de Almeida TC; Nuclear Technology Development Center (CDTN), Biological Science Institute - Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.; Department of Morphology, Biological Science Institute - Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Lanza K; Interdisciplinary Laboratory of Medical Investigation, Biological Science Institute - Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
da Silva Filha R; Interdisciplinary Laboratory of Medical Investigation, Biological Science Institute - Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
C Campos LMC; Department of Physiology and Biophysics, Biological Science Institute - Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Fonseca EG; Department of Physiology and Biophysics, Biological Science Institute - Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Chagas MW; Department of Physiology and Biophysics, Biological Science Institute - Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Rocha NP; Interdisciplinary Laboratory of Medical Investigation, Biological Science Institute - Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
de Sá MA; Department of Morphology, Biological Science Institute - Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Vieira MAR; Department of Physiology and Biophysics, Biological Science Institute - Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Caliari MV; Department of General Pathology, Biological Science Institute - Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Kangussu LM; Department of Morphology, Biological Science Institute - Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Ferreira AJ; Department of Morphology, Biological Science Institute - Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Simões E Silva AC; Interdisciplinary Laboratory of Medical Investigation, Biological Science Institute - Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
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Źródło :
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2020 Dec 11; Vol. 134 (23), pp. 3093-3106.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Kidney Injury/*drug therapy
Acute Kidney Injury/*enzymology
Angiotensin-Converting Enzyme 2/*metabolism
Diminazene/*analogs & derivatives
Enzyme Activators/*pharmacology
Gentamicins/*adverse effects
Kidney/*pathology
Protective Agents/*therapeutic use
Acute Kidney Injury/physiopathology ; Acute Kidney Injury/urine ; Animals ; Biomarkers/metabolism ; Body Weight/drug effects ; Cytokines/metabolism ; Diminazene/pharmacology ; Diminazene/therapeutic use ; Inflammation/pathology ; Kidney/drug effects ; Kidney/physiopathology ; Male ; Protective Agents/pharmacology ; Rats, Wistar ; Renin-Angiotensin System
Czasopismo naukowe
Tytuł :
Occurrence of Trypanosoma spp. and piroplasm infections of horses at Obollo-Afor southeastern Nigeria and resistance profiles of trypanosomes to isometamidium and diminazene salts.
Autorzy :
Emeto UE; Department of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
Okolo CC; Department of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria. .
Nweze NE; Department of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
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Źródło :
Tropical animal health and production [Trop Anim Health Prod] 2020 Nov; Vol. 52 (6), pp. 3745-3753. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Babesiosis/*parasitology
Diminazene/*analogs & derivatives
Horse Diseases/*parasitology
Phenanthridines/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosomiasis/*veterinary
Animals ; Babesiosis/epidemiology ; Cross-Sectional Studies ; Diminazene/pharmacology ; Drug Resistance ; Horse Diseases/epidemiology ; Horses ; Mice ; Mice, Inbred BALB C ; Nigeria/epidemiology ; Rats ; Trypanosoma brucei brucei/drug effects ; Trypanosomiasis/parasitology
Czasopismo naukowe
Tytuł :
Colloidal gold-based immunochromatographic strip assay for the rapid detection of diminazene in milk.
Autorzy :
Chen L; School of Food Science and Technology, Jiangnan University , Wuxi, Jiangsu, China.; Key Laboratory for Animal Immunology of the Ministry of Agriculture, Henan Academy of Agricultural Sciences , Zhengzhou, China.
Sun Y; Key Laboratory for Animal Immunology of the Ministry of Agriculture, Henan Academy of Agricultural Sciences , Zhengzhou, China.
Hu X; Key Laboratory for Animal Immunology of the Ministry of Agriculture, Henan Academy of Agricultural Sciences , Zhengzhou, China.
Xing Y; Key Laboratory for Animal Immunology of the Ministry of Agriculture, Henan Academy of Agricultural Sciences , Zhengzhou, China.
Kwee S; Department of Biomedical Engineering, University of Texas at San Antonio , San Antonio, TX, USA.
Na G; School of Food Science and Technology, Jiangnan University , Wuxi, Jiangsu, China.
Zhang G; School of Food Science and Technology, Jiangnan University , Wuxi, Jiangsu, China.; Key Laboratory for Animal Immunology of the Ministry of Agriculture, Henan Academy of Agricultural Sciences , Zhengzhou, China.
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Źródło :
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment [Food Addit Contam Part A Chem Anal Control Expo Risk Assess] 2020 Oct; Vol. 37 (10), pp. 1667-1677. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Immunoassay*
Diminazene/*analysis
Food Contamination/*analysis
Gold Colloid/*chemistry
Milk/*chemistry
Animals ; Antibodies, Monoclonal/immunology ; Diminazene/immunology
Czasopismo naukowe
Tytuł :
Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study.
Autorzy :
Souza-Silva TG; Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Department of Structural Biology, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil.
Vilas-Boas DF; Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Department of Structural Biology, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil.
Gonçalves-Santos E; Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Department of Structural Biology, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil.
Mazzeti AL; Fundação Oswaldo Cruz - FIOCRUZ, 21040900 Rio de Janeiro, Brazil.
Caldas IS; Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Department of Pathology and Parasitology, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil.
Gonçalves RV; Department of Animal Biology, Federal University of Viçosa, Viçosa 36570-000, Minas Gerais, Brazil.
Diniz LF; Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Department of Pathology and Parasitology, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil.
Novaes RD; Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Department of Structural Biology, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 15; Vol. 257, pp. 118067. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Chagas Cardiomyopathy/*drug therapy
Chagas Disease/*drug therapy
Diminazene/*analogs & derivatives
Myocytes, Cardiac/*drug effects
Renin-Angiotensin System/*drug effects
Angiotensin I/metabolism ; Animals ; Cell Line ; Chagas Cardiomyopathy/parasitology ; Chagas Disease/parasitology ; Diminazene/administration & dosage ; Diminazene/pharmacology ; Dose-Response Relationship, Drug ; Male ; Mice ; Mice, Inbred BALB C ; Myocarditis/drug therapy ; Myocarditis/parasitology ; Myocytes, Cardiac/parasitology ; Myositis/drug therapy ; Myositis/parasitology ; Peptide Fragments/metabolism ; Rats ; Trypanocidal Agents/administration & dosage ; Trypanocidal Agents/pharmacology
Czasopismo naukowe
Tytuł :
Comparison of therapeutic efficacy of different drugs against Trypanosoma vivax on experimentally infected cattle.
Autorzy :
Bastos TSA; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Faria AM; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
de Assis Cavalcante AS; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
de Carvalho Madrid DM; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Zapa DMB; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Nicaretta JE; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Cruvinel LB; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Heller LM; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Couto LFM; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Soares VE; Universidade Brasil, Campus de Descalvado, São Paulo, SP, Brazil.
Cadioli FA; Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista - Unesp, Araçatuba, SP, Brazil.
Lopes WDZ; Departamento de Biociências e Tecnologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil. Electronic address: .
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Źródło :
Preventive veterinary medicine [Prev Vet Med] 2020 Aug; Vol. 181, pp. 105040. Date of Electronic Publication: 2020 May 30.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Diminazene/*analogs & derivatives
Imidocarb/*analogs & derivatives
Phenanthridines/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma vivax/*drug effects
Trypanosomiasis, African/*prevention & control
Trypanosomiasis, Bovine/*prevention & control
Animals ; Cattle ; Diminazene/pharmacology ; Dose-Response Relationship, Drug ; Imidocarb/pharmacology ; Male
Czasopismo naukowe
Tytuł :
ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice.
Autorzy :
Duan R; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
Xue X; Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, People's Republic of China.
Zhang QQ; Department of Pathology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, People's Republic of China.
Wang SY; Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, People's Republic of China.
Gong PY; Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, People's Republic of China.
E Y; Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, People's Republic of China.
Jiang T; Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, People's Republic of China.
Zhang YD; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.; Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, People's Republic of China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Jul 23; Vol. 12 (14), pp. 14819-14829. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*drug therapy
Angiotensin-Converting Enzyme 2/*drug effects
Cognitive Dysfunction/*drug therapy
Diminazene/*analogs & derivatives
Alzheimer Disease/pathology ; Alzheimer Disease/psychology ; Amyloid beta-Peptides/biosynthesis ; Amyloid beta-Peptides/genetics ; Angiotensin I/metabolism ; Animals ; Brain Chemistry/drug effects ; Brain Chemistry/genetics ; Cognitive Dysfunction/etiology ; Cytokines/biosynthesis ; Diminazene/therapeutic use ; Infusions, Parenteral ; Male ; Maze Learning ; Mice ; Mice, Neurologic Mutants ; Peptide Fragments/biosynthesis ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Proto-Oncogene Proteins/genetics ; Receptors, G-Protein-Coupled/genetics ; tau Proteins/biosynthesis
Czasopismo naukowe
Tytuł :
Diminazene aceturate extenuate the renal deleterious consequences of angiotensin-II induced by γ-irradiation through boosting ACE2 signaling cascade.
Autorzy :
Hasan HF; Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Egypt. Electronic address: .
Elgazzar EM; Health Radiation Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
Mostafa DM; Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Egypt.
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Źródło :
Life sciences [Life Sci] 2020 Jul 15; Vol. 253, pp. 117749. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin II/*metabolism
Diminazene/*analogs & derivatives
Gamma Rays/*adverse effects
Oxidative Stress/*drug effects
Peptidyl-Dipeptidase A/*metabolism
Angiotensin I/metabolism ; Angiotensin II/administration & dosage ; Angiotensin-Converting Enzyme 2 ; Animals ; Diminazene/pharmacology ; Glutathione/metabolism ; Male ; Peptide Fragments/metabolism ; Proto-Oncogene Proteins/metabolism ; Rats ; Rats, Wistar ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/drug effects ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
Relaxation Dynamics of the Triazene Compound Berenil in DNA-Minor-Groove Confinement after Photoexcitation.
Autorzy :
Marefat Khah A; Quantum Chemistry Group, Ruhr University of Bochum, D-44780 Bochum, Germany.
Reinholdt P; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, 5230 Odense, Denmark.
Nuernberger P; Institut für Physikalische und Theoretische Chemie, Universität Regensburg, 93040 Regensburg, Germany.
Kongsted J; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, 5230 Odense, Denmark.
Hättig C; Quantum Chemistry Group, Ruhr University of Bochum, D-44780 Bochum, Germany.
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Źródło :
Journal of chemical theory and computation [J Chem Theory Comput] 2020 Aug 11; Vol. 16 (8), pp. 5203-5211. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
DNA/*chemistry
Diminazene/*analogs & derivatives
Diminazene/chemistry ; Photochemical Processes ; Quantum Theory
Czasopismo naukowe
Tytuł :
Efficacy of VERYL® in the treatment of cattle naturally infected with gastro-intestinal nematodes in Kenya.
Autorzy :
Maichomo MW; Kenya Agricultural & Livestock Research Organization (KALRO), Veterinary Research Institute, Muguga North, P.O. Box 32-00902, Kikuyu, Kenya. .
Nginyi JM; Kenya Agricultural & Livestock Research Organization (KALRO), Veterinary Research Institute, Muguga North, P.O. Box 32-00902, Kikuyu, Kenya.
Caruso-Varès A; Ceva Santé Animale, 10 av. de La Ballastière, 33500, Libourne, France.
Mungube EO; Kenya Agricultural & Livestock Research Organization (KALRO), Veterinary Research Institute, Muguga North, P.O. Box 32-00902, Kikuyu, Kenya.
Pagny G; Ceva Santé Animale, 10 av. de La Ballastière, 33500, Libourne, France.
Chevtzoff C; Ceva Santé Animale, 10 av. de La Ballastière, 33500, Libourne, France.
Njanja JC; Kenya Agricultural & Livestock Research Organization (KALRO), Veterinary Research Institute, Muguga North, P.O. Box 32-00902, Kikuyu, Kenya.
Lumumba PA; Kenya Agricultural & Livestock Research Organization (KALRO), Veterinary Research Institute, Muguga North, P.O. Box 32-00902, Kikuyu, Kenya.
Collin JF; Ceva Santé Animale, 10 av. de La Ballastière, 33500, Libourne, France.
Isaka N; Ceva Santé Animale, 10 av. de La Ballastière, 33500, Libourne, France.
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Źródło :
Tropical animal health and production [Trop Anim Health Prod] 2020 Jul; Vol. 52 (4), pp. 1699-1705. Date of Electronic Publication: 2019 Dec 21.
Typ publikacji :
Clinical Trial, Veterinary; Journal Article
MeSH Terms :
Anthelmintics/*therapeutic use
Cattle Diseases/*drug therapy
Diminazene/*analogs & derivatives
Levamisole/*therapeutic use
Nematode Infections/*veterinary
Animals ; Cattle ; Diminazene/therapeutic use ; Feces/parasitology ; Haemonchus/isolation & purification ; Kenya ; Nematode Infections/drug therapy ; Parasite Egg Count/veterinary ; Random Allocation ; Trichostrongylus/isolation & purification
Czasopismo naukowe
Tytuł :
Azithromycin and Diminazene Aceturate Combination Therapy in Experimental Multidrug-resistant Trypanosoma brucei brucei Infection in Albino Rats.
Autorzy :
Obi CF; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
Ezeh IO; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria. Electronic address: .
Okpala MI; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
Idika IK; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
Mbe N; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
Nwobi LG; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
Ezeokonkwo RC; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
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Źródło :
Veterinary parasitology [Vet Parasitol] 2020 Jun; Vol. 282, pp. 109138. Date of Electronic Publication: 2020 May 16.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Multiple*
Azithromycin/*pharmacology
Diminazene/*analogs & derivatives
Trypanocidal Agents/*pharmacology
Trypanosoma brucei brucei/*drug effects
Animals ; Diminazene/pharmacology ; Drug Therapy, Combination/veterinary ; Female ; Rats
Czasopismo naukowe
Tytuł :
Effect of spinal angiotensin-converting enzyme 2 activation on the formalin-induced nociceptive response in mice.
Autorzy :
Nemoto W; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan. Electronic address: .
Yamagata R; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.
Nakagawasai O; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.
Nakagawa K; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.
Hung WY; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.
Fujita M; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.
Tadano T; Complementary and Alternative Medicine Clinical Research and Development, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
Tan-No K; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Apr 05; Vol. 872, pp. 172950. Date of Electronic Publication: 2020 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
Diminazene/*analogs & derivatives
Pain/*drug therapy
Peptidyl-Dipeptidase A/*metabolism
Spinal Cord/*drug effects
p38 Mitogen-Activated Protein Kinases/*metabolism
Angiotensin I/pharmacology ; Angiotensin II/analogs & derivatives ; Angiotensin II/pharmacology ; Angiotensin-Converting Enzyme 2 ; Animals ; Diminazene/administration & dosage ; Disease Models, Animal ; Formaldehyde/toxicity ; Humans ; Injections, Spinal ; Male ; Mice ; Microglia/metabolism ; Neurons/metabolism ; Nociception/drug effects ; Nociception/physiology ; Pain/chemically induced ; Peptide Fragments/pharmacology ; Phosphorylation/drug effects ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/metabolism ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Receptors, G-Protein-Coupled/metabolism ; Spinal Cord/cytology ; Spinal Cord/metabolism
Czasopismo naukowe
Tytuł :
Molecular identification of diminazene aceturate-resistant strains of Trypanosoma congolense in naturally infected domestic animals of Yoko in the centre region of Cameroon.
Autorzy :
Mewamba EM; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO. Box 67, Dschang, Cameroon.
Farikou O; University of Bamenda, Cameroon.
Kamga RMN; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO. Box 67, Dschang, Cameroon.
Magang MEK; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO. Box 67, Dschang, Cameroon.
Tume C; University of Dschang Faculty of Sciences, Dschang, Cameroon.
Tiofack AAZ; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO. Box 67, Dschang, Cameroon.
Ravel S; Institut de Recherche pour le Développement, UMR INTERTRYP, Montpellier, France.
Simo G; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO. Box 67, Dschang, Cameroon. Electronic address: .
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Źródło :
Veterinary parasitology, regional studies and reports [Vet Parasitol Reg Stud Reports] 2020 Apr; Vol. 20, pp. 100405. Date of Electronic Publication: 2020 Mar 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cattle Diseases/*parasitology
Diminazene/*analogs & derivatives
Drug Resistance/*genetics
Sheep Diseases/*parasitology
Trypanocidal Agents/*pharmacology
Trypanosoma congolense/*genetics
Trypanosomiasis, African/*veterinary
Animals ; Cameroon ; Cattle ; Cross-Sectional Studies ; Diminazene/pharmacology ; Sheep ; Sheep, Domestic ; Trypanosoma congolense/drug effects ; Trypanosoma congolense/isolation & purification ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole.
Autorzy :
Czarnomysy R; Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.
Radomska D; Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.
Muszyńska A; Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.
Hermanowicz JM; Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.
Prokop I; Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.
Bielawska A; Department of Biotechnology, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.
Bielawski K; Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jun 21; Vol. 25 (12). Date of Electronic Publication: 2020 Jun 21.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Autophagosomes/*drug effects
Breast Neoplasms/*drug therapy
Coordination Complexes/*pharmacology
Diminazene/*analogs & derivatives
Nitroimidazoles/*chemistry
Organometallic Compounds/*pharmacology
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; DNA/drug effects ; DNA/metabolism ; DNA Topoisomerases, Type II/metabolism ; Diminazene/chemistry ; Female ; Gold/pharmacology ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Palladium/pharmacology ; Platinum/pharmacology ; Transition Elements/chemistry ; Xenograft Model Antitumor Assays ; Zebrafish
Czasopismo naukowe
Tytuł :
Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways.
Autorzy :
Liao YSJ; Department of Physiological Sciences University of Florida, Gainesville, Florida.
Kuan SP; Department of Physiological Sciences University of Florida, Gainesville, Florida.
Guevara MV; Department of Physiological Sciences University of Florida, Gainesville, Florida.
Collins EN; Department of Physiological Sciences University of Florida, Gainesville, Florida.
Atanasova KR; Department of Physiological Sciences University of Florida, Gainesville, Florida.
Dadural JS; Department of Physiological Sciences University of Florida, Gainesville, Florida.
Vogt K; Department of Physiological Sciences University of Florida, Gainesville, Florida.
Schurmann V; Department of Physiological Sciences University of Florida, Gainesville, Florida.
Bravo L; Department of Physiological Sciences University of Florida, Gainesville, Florida.
Eken E; Department of Physiological Sciences University of Florida, Gainesville, Florida.
Sponchiado M; Department of Physiological Sciences University of Florida, Gainesville, Florida.
Reznikov LR; Department of Physiological Sciences University of Florida, Gainesville, Florida.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2020 May 01; Vol. 318 (5), pp. L873-L887. Date of Electronic Publication: 2020 Mar 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Acetic Acid/*administration & dosage
Acid Sensing Ion Channel Blockers/*pharmacology
Acid Sensing Ion Channels/*genetics
Airway Obstruction/*chemically induced
Cystic Fibrosis/*chemically induced
Diminazene/*analogs & derivatives
Acid Sensing Ion Channels/metabolism ; Airway Obstruction/drug therapy ; Airway Obstruction/metabolism ; Airway Obstruction/pathology ; Animals ; Animals, Newborn ; Bicarbonates/metabolism ; Bronchi/drug effects ; Bronchi/metabolism ; Bronchi/pathology ; Bronchoalveolar Lavage Fluid/chemistry ; Chlorides/metabolism ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/metabolism ; Cystic Fibrosis/pathology ; Diminazene/pharmacology ; Disease Models, Animal ; Female ; Gene Expression ; Humans ; Hydrogen-Ion Concentration ; Male ; Mucin 5AC/genetics ; Mucin 5AC/metabolism ; Mucin-5B/genetics ; Mucin-5B/metabolism ; Mucociliary Clearance/drug effects ; Mucus/metabolism ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Swine ; Trachea/drug effects ; Trachea/metabolism ; Trachea/pathology
Czasopismo naukowe
Tytuł :
Diminazene aceturate (DIZE) has cellular and in vivo antiarrhythmic effects.
Autorzy :
Joviano-Santos JV; Department of Morphology, Institute of Biological Sciences, Federal University of Minas, Gerais, Brazil.
Santos-Miranda A; Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas, Gerais, Brazil.
Joca HC; Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas, Gerais, Brazil.
Cruz JS; Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas, Gerais, Brazil.
Ferreira AJ; Department of Morphology, Institute of Biological Sciences, Federal University of Minas, Gerais, Brazil.
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Źródło :
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2020 Feb; Vol. 47 (2), pp. 213-219. Date of Electronic Publication: 2019 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Arrhythmia Agents/*therapeutic use
Arrhythmias, Cardiac/*drug therapy
Diminazene/*analogs & derivatives
Myocytes, Cardiac/*drug effects
Animals ; Anti-Arrhythmia Agents/pharmacology ; Arrhythmias, Cardiac/physiopathology ; Diminazene/pharmacology ; Diminazene/therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Myocytes, Cardiac/physiology ; Patch-Clamp Techniques/methods ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Stimulation of the ACE2/Ang-(1-7)/Mas axis in hypertensive pregnant rats attenuates cardiovascular dysfunction in adult male offspring.
Autorzy :
Bessa ASM; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Jesus ÉF; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Nunes ADC; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Pontes CNR; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Lacerda IS; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Costa JM; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Souza EJ; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Lino-Júnior RS; Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Biancardi MF; Departamento de Histologia, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Dos Santos FCA; Departamento de Histologia, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Pedrino GR; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Colugnati DB; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Mazaro-Costa R; Departamento de Farmacologia, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Mendes EP; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil.
Castro CH; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil. .
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Źródło :
Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2019 Dec; Vol. 42 (12), pp. 1883-1893. Date of Electronic Publication: 2019 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin I/*pharmacology
Cardiovascular Diseases/*prevention & control
Diminazene/*analogs & derivatives
Enzyme Activators/*pharmacology
Hypertension, Pregnancy-Induced/*drug therapy
Peptide Fragments/*pharmacology
Peptidyl-Dipeptidase A/*drug effects
Angiotensin-Converting Enzyme 2 ; Animals ; Blood Pressure/drug effects ; Diminazene/pharmacology ; Female ; Heart/drug effects ; Kidney/drug effects ; Male ; Myocardial Contraction ; Pregnancy ; Prenatal Exposure Delayed Effects ; Rats ; Ventricular Function, Left
Czasopismo naukowe
Tytuł :
The role of SARS-CoV-2 target ACE2 in cardiovascular diseases.
Autorzy :
Zhu H; Department of Cardiovascular Surgery, The First Affiliated Hospital, The Air Force Medical University, Xi'an, China.
Zhang L; Department of Cardiovascular Surgery, The First Affiliated Hospital, The Air Force Medical University, Xi'an, China.
Ma Y; Department of Dermatology and Venereology, Peking University First Hospita, Beijing, China.
Zhai M; Department of Cardiovascular Surgery, The First Affiliated Hospital, The Air Force Medical University, Xi'an, China.
Xia L; Department of Cardiovascular Surgery, The First Affiliated Hospital, The Air Force Medical University, Xi'an, China.
Liu J; Department of Cardiovascular Surgery, The First Affiliated Hospital, The Air Force Medical University, Xi'an, China.
Yu S; Department of Cardiovascular Surgery, The First Affiliated Hospital, The Air Force Medical University, Xi'an, China.
Duan W; Department of Cardiovascular Surgery, The First Affiliated Hospital, The Air Force Medical University, Xi'an, China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2021 Feb; Vol. 25 (3), pp. 1342-1349. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*complications
Cardiovascular Diseases/*metabolism
Angiotensin-Converting Enzyme 2/pharmacology ; Animals ; Arrhythmias, Cardiac/metabolism ; Arrhythmias, Cardiac/physiopathology ; COVID-19/drug therapy ; COVID-19/metabolism ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/physiopathology ; Diminazene/pharmacology ; Heart Failure/etiology ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Myocardial Infarction/drug therapy ; Myocardial Infarction/metabolism ; Myocardial Infarction/physiopathology ; Recombinant Proteins/pharmacology
Czasopismo naukowe
Tytuł :
Suspected resistance of Trypanosoma species to diminazene aceturate on a cattle farm in Nigeria.
Autorzy :
Odeniran PO; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria, Ibadan, Nigeria. .; Division of Infection and Pathway Medicine, University of Edinburgh, Edinburgh, EH8 9YL, UK. .
Macleod ET; Division of Infection and Pathway Medicine, University of Edinburgh, Edinburgh, EH8 9YL, UK.
Ademola IO; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria, Ibadan, Nigeria.
Welburn SC; Division of Infection and Pathway Medicine, University of Edinburgh, Edinburgh, EH8 9YL, UK.; Zhejiang University - University of Edinburgh Joint Institute, Zhejiang University, International Campus, 718 East Haizhou Road, Haining, 314400, China.
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Źródło :
Tropical animal health and production [Trop Anim Health Prod] 2019 Sep; Vol. 51 (7), pp. 2091-2094. Date of Electronic Publication: 2019 Apr 17.
Typ publikacji :
Journal Article
MeSH Terms :
Diminazene/*analogs & derivatives
Trypanocidal Agents/*therapeutic use
Trypanosoma congolense/*genetics
Trypanosomiasis, African/*veterinary
Trypanosomiasis, Bovine/*drug therapy
Animals ; Cattle ; Cattle Diseases/drug therapy ; Cattle Diseases/parasitology ; DNA, Intergenic ; Diminazene/pharmacology ; Drug Resistance ; Farms ; Nigeria ; Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
In silico analysis of heparin and chondroitin sulfate binding mechanisms of the antiprotozoal drug berenil and pentamidine.
Autorzy :
Samsonov SA; Laboratory of Molecular Modeling, Faculty of Chemistry, University of Gdańsk, ul. Wita Stwosza 63, 80-308, Gdańsk, Poland. Electronic address: .
Freza S; Laboratory of Quantum Chemistry, Faculty of Chemistry, University of Gdańsk, ul. Wita Stwosza 63, 80-308, Gdańsk, Poland.
Zsila F; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences H-1117 Budapest, Magyar tudósok körútja 2, Hungary.
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Źródło :
Carbohydrate research [Carbohydr Res] 2019 Aug 01; Vol. 482, pp. 107742. Date of Electronic Publication: 2019 Jul 11.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Antiprotozoal Agents/*metabolism
Chondroitin Sulfates/*metabolism
Diminazene/*analogs & derivatives
Heparin/*metabolism
Pentamidine/*metabolism
Diminazene/chemistry ; Diminazene/metabolism ; Hydrogen Bonding ; Molecular Conformation ; Molecular Dynamics Simulation ; Pentamidine/chemistry ; Quantum Theory ; Thermodynamics
Czasopismo naukowe

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