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    Wyświetlanie 1-7 z 7
    Tytuł:
    Prodrug polymeric micelles integrating cancer-associated fibroblasts deactivation and synergistic chemotherapy for gastric cancer.
    Autorzy:
    Zheng S; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
    Wang J; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
    Ding N; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
    Chen W; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
    Chen H; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
    Xue M; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
    Chen F; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
    Ni J; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
    Wang Z; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
    Lin Z; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
    Jiang H; Department of Medical Oncology, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, 310016, China.
    Liu X; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. .; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, 310058, China. .; Cancer Center, Zhejiang University, Hangzhou, 310058, China. .
    Wang L; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. .; Institute of Gastroenterology, Zhejiang University, Hangzhou, 310058, China. .; Cancer Center, Zhejiang University, Hangzhou, 310058, China. .
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    Źródło:
    Journal of nanobiotechnology [J Nanobiotechnology] 2021 Nov 21; Vol. 19 (1), pp. 381. Date of Electronic Publication: 2021 Nov 21.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antineoplastic Agents*/chemistry
    Antineoplastic Agents*/pharmacokinetics
    Antineoplastic Agents*/pharmacology
    Micelles*
    Prodrugs*/chemistry
    Prodrugs*/pharmacokinetics
    Prodrugs*/pharmacology
    Stomach Neoplasms/*metabolism
    Animals ; Cancer-Associated Fibroblasts/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Diterpenes/chemistry ; Diterpenes/pharmacokinetics ; Diterpenes/pharmacology ; Drug Synergism ; Epoxy Compounds/chemistry ; Epoxy Compounds/pharmacokinetics ; Epoxy Compounds/pharmacology ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Phenanthrenes/chemistry ; Phenanthrenes/pharmacokinetics ; Phenanthrenes/pharmacology ; Tumor Microenvironment/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design, Synthesis and Biological Evaluation of a New Series of 1-Aryl-3-{4-[(pyridin-2-ylmethyl)thio]phenyl}urea Derivatives as Antiproliferative Agents.
    Autorzy:
    Zhang C; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. chuanming_.
    Tan X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. .
    Feng J; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. .
    Ding N; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. .
    Li Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. .
    Jin Z; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. .
    Meng Q; Department of Pharmacy, Yantai University, Yantai 264005, China. .
    Liu X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. .
    Hu C; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2019 Jun 04; Vol. 24 (11). Date of Electronic Publication: 2019 Jun 04.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Drug Design*
    Antineoplastic Agents/*chemistry
    Antineoplastic Agents/*pharmacology
    Phenylurea Compounds/*chemistry
    Phenylurea Compounds/*pharmacology
    Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Chemistry Techniques, Synthetic ; Drug Screening Assays, Antitumor ; Humans ; Hydrogen Bonding ; Molecular Structure ; Phenylurea Compounds/chemical synthesis ; Spectrum Analysis ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Sesquiterpenoids from Streptomyces anulatus isolated from Giraffa camelopardalis feces.
    Autorzy:
    Ding N; Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, China.
    Han L; Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, China.
    Jiang Y; Yunnan Institute of Microbiology, Yunnan University, Kunming, 650091, China.
    Li G; Yunnan Institute of Microbiology, Yunnan University, Kunming, 650091, China.
    Liu J; Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, China.
    Mu Y; Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, China.
    Huang X; Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, China.
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    Źródło:
    Magnetic resonance in chemistry : MRC [Magn Reson Chem] 2018 May; Vol. 56 (5), pp. 352-359. Date of Electronic Publication: 2018 Feb 07.
    Typ publikacji:
    Letter; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*chemistry
    Feces/*microbiology
    Giraffes/*microbiology
    Sesquiterpenes/*chemistry
    Streptomyces/*metabolism
    Animals ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Cell Line ; Cell Survival/drug effects ; Fermentation ; Humans ; Molecular Structure ; Sesquiterpenes/isolation & purification ; Sesquiterpenes/pharmacology ; Structure-Activity Relationship
    Raport
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design, Synthesis, and Antitumor Activity of (E,Z)-1-(dihydrobenzofuran-5-yl)-3-phenyl-2-(1,2,4-triazol-1-yl)-2-propen-1-ones.
    Autorzy:
    Li W; College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
    Yang ZH; College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
    Hu AX; College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
    Yan XW; College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
    Ding N; College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
    Ye J; College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
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    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2015 Dec; Vol. 86 (6), pp. 1339-50. Date of Electronic Publication: 2015 Jun 23.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Drug Design*
    Antineoplastic Agents/*chemical synthesis
    Antineoplastic Agents/*pharmacology
    Benzofurans/*chemical synthesis
    Benzofurans/*pharmacology
    Neoplasms/*drug therapy
    Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Benzofurans/chemistry ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Female ; HEK293 Cells ; HeLa Cells ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; MCF-7 Cells ; Neoplasms/pathology ; Structure-Activity Relationship ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activation.
    Autorzy:
    Zhou DY; Laboratory of Natural Medicinal Chemistry & Green Chemistry, Guangdong University of Technology, Guangzhou, Guangdong 510006, P.R. China.
    Ding N; Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
    Du ZY; Laboratory of Natural Medicinal Chemistry & Green Chemistry, Guangdong University of Technology, Guangzhou, Guangdong 510006, P.R. China.
    Cui XX; Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
    Wang H; Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
    Wei XC; Laboratory of Natural Medicinal Chemistry & Green Chemistry, Guangdong University of Technology, Guangzhou, Guangdong 510006, P.R. China.
    Conney AH; Laboratory of Natural Medicinal Chemistry & Green Chemistry, Guangdong University of Technology, Guangzhou, Guangdong 510006, P.R. China.
    Zhang K; Laboratory of Natural Medicinal Chemistry & Green Chemistry, Guangdong University of Technology, Guangzhou, Guangdong 510006, P.R. China.
    Zheng X; Laboratory of Natural Medicinal Chemistry & Green Chemistry, Guangdong University of Technology, Guangzhou, Guangdong 510006, P.R. China.
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    Źródło:
    Molecular medicine reports [Mol Med Rep] 2014 Sep; Vol. 10 (3), pp. 1315-22. Date of Electronic Publication: 2014 Jul 14.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*pharmacology
    Curcumin/*pharmacology
    Receptors, Androgen/*metabolism
    Apoptosis/drug effects ; Cell Line, Tumor ; Curcumin/analogs & derivatives ; Dihydrotestosterone/antagonists & inhibitors ; Dihydrotestosterone/metabolism ; Humans ; Male ; Prostate-Specific Antigen/genetics ; Prostate-Specific Antigen/metabolism ; Prostatic Neoplasms/metabolism ; Receptors, Androgen/genetics ; Signal Transduction ; Testosterone/antagonists & inhibitors ; Testosterone/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Preparation and in vitro evaluation of a folate-linked liposomal curcumin formulation.
    Autorzy:
    Lu Y; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Ding N
    Yang C
    Huang L
    Liu J
    Xiang G
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    Źródło:
    Journal of liposome research [J Liposome Res] 2012 Jun; Vol. 22 (2), pp. 110-9. Date of Electronic Publication: 2012 Feb 28.
    Typ publikacji:
    Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*chemistry
    Antineoplastic Agents/*pharmacology
    Curcumin/*chemistry
    Curcumin/*pharmacology
    Folic Acid/*chemistry
    Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Chemistry, Pharmaceutical ; Drug Screening Assays, Antitumor ; HeLa Cells ; Humans ; KB Cells ; Liposomes/chemistry ; Solubility ; Structure-Activity Relationship ; Tumor Cells, Cultured
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    In vitro evaluation of a Folate-bovine serum albumin-doxorubicin conjugate.
    Autorzy:
    Qu X; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Yang C
    Zhang J
    Ding N
    Lu Y
    Huang L
    Xiang G
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    Źródło:
    Journal of drug targeting [J Drug Target] 2010 Jun; Vol. 18 (5), pp. 351-61.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*pharmacology
    Doxorubicin/*pharmacology
    Serum Albumin, Bovine/*administration & dosage
    Antineoplastic Agents/administration & dosage ; Doxorubicin/administration & dosage ; Drug Evaluation, Preclinical ; HeLa Cells ; Humans ; In Vitro Techniques ; Spectrophotometry, Ultraviolet
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-7 z 7

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