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Tytuł:
Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kγ, AMPK and GRK2.
Autorzy:
König C; Institute of Physiology 1/Neurophysiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Ebersberger A; Institute of Physiology 1/Neurophysiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Eitner A; Institute of Physiology 1/Neurophysiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.; Department of Trauma, Hand and Reconstructive Surgery, Experimental Trauma Surgery, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Wetzker R; Clinic for Anesthesiology and Intensive Care, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Schaible HG; Institute of Physiology 1/Neurophysiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2023 Feb; Vol. 180 (4), pp. 441-458. Date of Electronic Publication: 2022 Nov 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Prostaglandins*
AMP-Activated Protein Kinases*
Animals ; Mice ; Phosphatidylinositol 3-Kinase ; Phosphatidylinositol 3-Kinases ; Dinoprostone/pharmacology ; Dinoprostone/metabolism ; Receptors, Prostaglandin E, EP4 Subtype ; Receptors, Prostaglandin E, EP2 Subtype ; Sensory Receptor Cells/metabolism ; Pain ; Analgesics ; Receptors, Prostaglandin E, EP3 Subtype/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The sigma-1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors.
Autorzy:
Ruiz-Cantero MC; Department of Pharmacology, Faculty of Medicine, University of Granada, Granada, Spain.; Institute of Neuroscience, Biomedical Research Center, University of Granada, Granada, Spain.; Biosanitary Research Institute ibs. GRANADA, Granada, Spain.
Cortés-Montero E; Department of Translational Neurosciences, Neuropharmacology, Cajal Institute, CSIC, Madrid, Spain.
Jain A; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Montilla-García Á; Department of Pharmacology, Faculty of Medicine, University of Granada, Granada, Spain.; Institute of Neuroscience, Biomedical Research Center, University of Granada, Granada, Spain.
Bravo-Caparrós I; Department of Pharmacology, Faculty of Medicine, University of Granada, Granada, Spain.; Institute of Neuroscience, Biomedical Research Center, University of Granada, Granada, Spain.
Shim J; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Sánchez-Blázquez P; Department of Translational Neurosciences, Neuropharmacology, Cajal Institute, CSIC, Madrid, Spain.
Woolf CJ; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Baeyens JM; Department of Pharmacology, Faculty of Medicine, University of Granada, Granada, Spain.; Institute of Neuroscience, Biomedical Research Center, University of Granada, Granada, Spain.; Biosanitary Research Institute ibs. GRANADA, Granada, Spain.
Cobos EJ; Department of Pharmacology, Faculty of Medicine, University of Granada, Granada, Spain.; Institute of Neuroscience, Biomedical Research Center, University of Granada, Granada, Spain.; Biosanitary Research Institute ibs. GRANADA, Granada, Spain.; Teófilo Hernando Institute for Drug Discovery, Madrid, Spain.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2023 Apr; Vol. 180 (8), pp. 1148-1167. Date of Electronic Publication: 2022 Dec 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nociceptors*/metabolism
Analgesia*
Mice ; Animals ; Hyperalgesia/metabolism ; Receptors, Opioid, mu/metabolism ; Analgesics, Opioid/pharmacology ; Nerve Growth Factor/metabolism ; Calcium/metabolism ; Dinoprostone/metabolism ; Pain/metabolism ; Opioid Peptides/metabolism ; TRPV Cation Channels/metabolism ; Ganglia, Spinal/metabolism ; Sigma-1 Receptor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bronchodilation induced by PGE 2 is impaired in Group III pulmonary hypertension.
Autorzy:
Ozen G; INSERM U1148, Hôpital Bichat, Paris, France.; Faculty of Pharmacy, Department of Pharmacology, Istanbul University, Istanbul, Turkey.
Benyahia C; INSERM U1148, Hôpital Bichat, Paris, France.; Paris 13 University (USPC), Villetaneuse, France.
Mani S; INSERM U1148, Hôpital Bichat, Paris, France.; Paris 13 University (USPC), Villetaneuse, France.; Institut Supérieur de Biotechnologie de Monastir (ISBM), Université de Monastir, Monastir, Tunisia.
Boukais K; INSERM U1148, Hôpital Bichat, Paris, France.
Silverstein AM; United Therapeutics, Research Triangle Park, NC, USA.
Bayles R; INSERM U1148, Hôpital Bichat, Paris, France.
Nelsen AC; United Therapeutics, Research Triangle Park, NC, USA.
Castier Y; Hôpital Bichat-Claude Bernard, AP-HP, Paris Diderot University, Université de Paris, Paris, France.
Danel C; Hôpital Bichat-Claude Bernard, AP-HP, Paris Diderot University, Université de Paris, Paris, France.
Mal H; Hôpital Bichat-Claude Bernard, AP-HP, Paris Diderot University, Université de Paris, Paris, France.
Clapp LH; Institute of Cardiovascular Science, University College London, London, UK.
Longrois D; INSERM U1148, Hôpital Bichat, Paris, France.; Paris 13 University (USPC), Villetaneuse, France.; Hôpital Bichat-Claude Bernard, AP-HP, Paris Diderot University, Université de Paris, Paris, France.
Norel X; INSERM U1148, Hôpital Bichat, Paris, France.; Paris 13 University (USPC), Villetaneuse, France.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2020 Jan; Vol. 177 (1), pp. 161-174. Date of Electronic Publication: 2019 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bronchi/*metabolism
Bronchodilator Agents/*metabolism
Bronchodilator Agents/*therapeutic use
Dinoprostone/*metabolism
Dinoprostone/*therapeutic use
Hypertension, Pulmonary/*metabolism
Adult ; Aged ; Aged, 80 and over ; Antihypertensive Agents/metabolism ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Bronchi/drug effects ; Bronchi/pathology ; Bronchodilator Agents/pharmacology ; Dinoprostone/pharmacology ; Dose-Response Relationship, Drug ; Epoprostenol/analogs & derivatives ; Epoprostenol/metabolism ; Epoprostenol/pharmacology ; Epoprostenol/therapeutic use ; Female ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/pathology ; Iloprost/metabolism ; Iloprost/pharmacology ; Iloprost/therapeutic use ; Male ; Middle Aged ; Organ Culture Techniques ; Pyrrolidinones/metabolism ; Pyrrolidinones/pharmacology ; Pyrrolidinones/therapeutic use ; Receptors, Prostaglandin E, EP4 Subtype/agonists ; Receptors, Prostaglandin E, EP4 Subtype/metabolism ; Tetrazoles/metabolism ; Tetrazoles/pharmacology ; Tetrazoles/therapeutic use ; Vasodilator Agents/metabolism ; Vasodilator Agents/pharmacology ; Vasodilator Agents/therapeutic use ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Host-directed anti-mycobacterial activity of colchicine, an anti-gout drug, via strengthened host innate resistance reinforced by the IL-1β/PGE 2 axis.
Autorzy:
Kwon KW; Department of Microbiology and Institute for Immunology and Immunological Disease, Brain Korea 21 Project for the Graduate School of Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
Kim LH; Department of Microbiology and Institute for Immunology and Immunological Disease, Brain Korea 21 Project for the Graduate School of Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
Kang SM; Department of Microbiology and Institute for Immunology and Immunological Disease, Brain Korea 21 Project for the Graduate School of Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
Lee JM; Department of Microbiology and Institute for Immunology and Immunological Disease, Brain Korea 21 Project for the Graduate School of Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
Choi E; Department of Microbiology and Institute for Immunology and Immunological Disease, Brain Korea 21 Project for the Graduate School of Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
Park J; Department of Microbiology and Institute for Immunology and Immunological Disease, Brain Korea 21 Project for the Graduate School of Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
Hong JJ; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology, Cheongju, South Korea.; KRIBB School of Bioscience, Korea University of Science & Technology (UST), Daejeon, South Korea.
Shin SJ; Department of Microbiology and Institute for Immunology and Immunological Disease, Brain Korea 21 Project for the Graduate School of Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2022 Aug; Vol. 179 (15), pp. 3951-3969. Date of Electronic Publication: 2022 Apr 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mycobacterium tuberculosis*
Tuberculosis*
Animals ; Colchicine/metabolism ; Colchicine/pharmacology ; Cyclooxygenase 2/metabolism ; Dinoprostone/pharmacology ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PGE 2 /EP 4 receptor attenuated mucosal injury via β-arrestin1/Src/EGFR-mediated proliferation in portal hypertensive gastropathy.
Autorzy:
Tan S; Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China.
Chen X; Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Xu M; Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Huang X; Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Liu H; Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jiang J; Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Lu Y; Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Peng X; Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Wu B; Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2017 May; Vol. 174 (9), pp. 848-866. Date of Electronic Publication: 2017 Mar 25.
Typ publikacji:
Journal Article
MeSH Terms:
Dinoprostone/*pharmacology
ErbB Receptors/*physiology
Gastric Mucosa/*pathology
Hypertension, Portal/*pathology
Receptors, Prostaglandin E, EP4 Subtype/*physiology
beta-Arrestin 1/*physiology
src-Family Kinases/*physiology
Animals ; Dinoprostone/therapeutic use ; Gastric Mucosa/drug effects ; Gastric Mucosa/metabolism ; Humans ; Hypertension, Portal/drug therapy ; Hypertension, Portal/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Random Allocation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The anti-inflammatory effects of PGE 2 on human lung macrophages are mediated by the EP 4 receptor.
Autorzy:
Gill SK; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK.
Yao Y; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK.
Kay LJ; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK.
Bewley MA; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK.
Marriott HM; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK.
Peachell PT; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK. .
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2016 Nov; Vol. 173 (21), pp. 3099-3109. Date of Electronic Publication: 2016 Sep 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Bacterial Agents/*pharmacology
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Dinoprostone/*pharmacology
Macrophages, Alveolar/*drug effects
Receptors, Prostaglandin E, EP4 Subtype/*metabolism
Anti-Bacterial Agents/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Dinoprostone/chemistry ; Humans ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/microbiology ; Microbial Sensitivity Tests ; Receptors, Prostaglandin E, EP4 Subtype/antagonists & inhibitors ; Receptors, Prostaglandin E, EP4 Subtype/genetics ; Streptococcus pneumoniae/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever.
Autorzy:
Malvar Ddo C; Laboratório de Farmacologia, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Aguiar FA
Vaz Ade L
Assis DC
de Melo MC
Jabor VA
Kalapothakis E
Ferreira SH
Clososki GC
de Souza GE
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2014 Aug; Vol. 171 (15), pp. 3666-79.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ampyrone/*pharmacology
Dinoprostone/*metabolism
Dipyrone/*analogs & derivatives
Fever/*drug therapy
Ampyrone/blood ; Ampyrone/cerebrospinal fluid ; Ampyrone/metabolism ; Animals ; Antipyretics/blood ; Antipyretics/cerebrospinal fluid ; Antipyretics/pharmacokinetics ; Antipyretics/pharmacology ; Body Temperature/drug effects ; Dinoprostone/cerebrospinal fluid ; Dipyrone/blood ; Dipyrone/cerebrospinal fluid ; Dipyrone/metabolism ; Dipyrone/pharmacokinetics ; Dipyrone/pharmacology ; Fever/chemically induced ; Fever/metabolism ; Hypothalamus/drug effects ; Hypothalamus/metabolism ; Hypothermia/chemically induced ; Hypothermia/metabolism ; Indomethacin/pharmacology ; Lipopolysaccharides ; Male ; Prodrugs/pharmacokinetics ; Rats, Wistar ; Scorpion Venoms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone.
Autorzy:
Larsson K; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Steinmetz J; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Bergqvist F; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Arefin S; Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Spahiu L; Biochemical Toxicology Unit, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Wannberg J; SciLifeLab Drug Discovery and Development Platform, Medicinal Chemistry-Lead Identification, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Pawelzik SC; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.; Theme Heart and Vessels, Division of Valvular and Coronary Diseases, Karolinska University Hospital, Stockholm, Sweden.
Morgenstern R; Biochemical Toxicology Unit, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Stenberg P; Gesynta Pharma AB, Solna, Sweden.
Kublickiene K; Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Korotkova M; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Jakobsson PJ; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2019 Dec; Vol. 176 (24), pp. 4625-4638. Date of Electronic Publication: 2019 Dec 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Inflammatory Agents/*pharmacology
Arteries/*drug effects
Dinoprostone/*biosynthesis
Edema/*drug therapy
Enzyme Inhibitors/*pharmacology
Muscle Tonus/*drug effects
Prostaglandin-E Synthases/*antagonists & inhibitors
A549 Cells ; Animals ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacokinetics ; Arteries/enzymology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Edema/immunology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacokinetics ; Escherichia coli/genetics ; Humans ; In Vitro Techniques ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Muscle Contraction/drug effects ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/enzymology ; Myography ; Prostaglandin-E Synthases/blood ; Prostaglandin-E Synthases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth.
Autorzy:
Qiu J; Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.; Cell Signal Transduction and Proteomics Research Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.
Li Q; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.
Bell KA; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.; Department of Biology, Gettysburg College, Gettysburg, Pennsylvania, USA.
Yao X; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.
Du Y; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.
Zhang E; Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Yu JJ; Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Yu Y; Department of Pharmaceutical Sciences and Drug Discovery Center, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Shi Z; Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
Jiang J; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.; Department of Pharmaceutical Sciences and Drug Discovery Center, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2019 Jun; Vol. 176 (11), pp. 1680-1699. Date of Electronic Publication: 2019 Apr 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclooxygenase 2/*metabolism
Dinoprostone/*metabolism
Glioma/*pathology
Receptors, Prostaglandin E, EP2 Subtype/*metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Glioma/genetics ; Glioma/metabolism ; Glioma/mortality ; Humans ; Indoles/pharmacology ; Kaplan-Meier Estimate ; Mice, Inbred C57BL ; Mice, Nude ; Receptors, Prostaglandin E, EP2 Subtype/antagonists & inhibitors ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prostamide F(2) α receptor antagonism combined with inhibition of FAAH may block the pro-inflammatory mediators formed following selective FAAH inhibition.
Autorzy:
Ligresti A; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy.
Martos J
Wang J
Guida F
Allarà M
Palmieri V
Luongo L
Woodward D
Di Marzo V
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2014 Mar; Vol. 171 (6), pp. 1408-19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amidohydrolases/*antagonists & inhibitors
Dinoprostone/*analogs & derivatives
Enzyme Inhibitors/*pharmacology
Inflammation Mediators/*antagonists & inhibitors
Receptors, Prostaglandin/*antagonists & inhibitors
Animals ; Cats ; Dinoprostone/metabolism ; HEK293 Cells ; Humans ; Inflammation Mediators/metabolism ; Mice ; Molecular Sequence Data
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity.
Autorzy:
Hu SS; Department of Psychological and Brain Sciences, the Gill Center for Biomolecular Science, Indiana University, Bloomington, IN, USA.
Bradshaw HB
Chen JS
Tan B
Walker JM
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2008 Apr; Vol. 153 (7), pp. 1538-49. Date of Electronic Publication: 2008 Feb 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Arachidonic Acids/*metabolism
Cyclooxygenase 2/*metabolism
Dinoprostone/*analogs & derivatives
Dinoprostone/*metabolism
Glycerides/*metabolism
Hyperalgesia/*etiology
Animals ; Cell Line ; Dinoprostone/biosynthesis ; Dinoprostone/pharmacology ; Endocannabinoids ; Hot Temperature ; Macrophages/metabolism ; Male ; Mass Spectrometry ; Mice ; NF-kappa B/metabolism ; Pain/etiology ; Pain Measurement ; Rats ; Rats, Sprague-Dawley ; Receptors, Prostaglandin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The antipyretic effect of dipyrone is unrelated to inhibition of PGE(2) synthesis in the hypothalamus.
Autorzy:
Malvar Ddo C; Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Soares DM
Fabrício AS
Kanashiro A
Machado RR
Figueiredo MJ
Rae GA
de Souza GE
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2011 Mar; Vol. 162 (6), pp. 1401-9.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antipyretics/*pharmacology
Body Temperature/*drug effects
Dinoprostone/*biosynthesis
Dipyrone/*pharmacology
Fever/*drug therapy
Hypothalamus/*drug effects
Animals ; Cyclooxygenase Inhibitors/pharmacology ; Dinoprostone/blood ; Dinoprostone/cerebrospinal fluid ; Endothelin-1/pharmacology ; Escherichia coli ; Fever/physiopathology ; Hypothalamus/metabolism ; Indomethacin/pharmacology ; Lipopolysaccharides/pharmacology ; Male ; Pyrogens/pharmacology ; Rats ; Rats, Wistar
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
PGE2 maintains the tone of the guinea pig trachea through a balance between activation of contractile EP1 receptors and relaxant EP2 receptors.
Autorzy:
Säfholm J; Unit for Experimental Asthma and Allergy Research, Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Dahlén SE
Delin I
Maxey K
Stark K
Cardell LO
Adner M
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2013 Feb; Vol. 168 (4), pp. 794-806.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dinoprostone/*pharmacology
Muscle Contraction/*drug effects
Muscle Tonus/*drug effects
Muscle, Smooth/*drug effects
Receptors, Prostaglandin E, EP1 Subtype/*biosynthesis
Receptors, Prostaglandin E, EP2 Subtype/*biosynthesis
Trachea/*drug effects
Animals ; Cyclooxygenase Inhibitors/pharmacology ; Dinoprostone/physiology ; Dose-Response Relationship, Drug ; Guinea Pigs ; Male ; Organ Culture Techniques ; RNA, Messenger/biosynthesis ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Species Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of biosynthesis and modes of action of prostaglandin E2 and prostacyclin in guinea pig mesenteric lymphatic vessels.
Autorzy:
Rehal S; Snyder Institute of Infection, Immunity & Inflammation and Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada.
Blanckaert P
Roizes S
von der Weid PY
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2009 Dec; Vol. 158 (8), pp. 1961-70.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dinoprostone/*pharmacology
Epoprostenol/*pharmacology
Receptors, Epoprostenol/*drug effects
Receptors, Prostaglandin E/*drug effects
Animals ; Dinoprostone/administration & dosage ; Dinoprostone/toxicity ; Dose-Response Relationship, Drug ; Edema/etiology ; Edema/physiopathology ; Epoprostenol/administration & dosage ; Epoprostenol/toxicity ; Guinea Pigs ; Lymphatic Vessels/drug effects ; Lymphatic Vessels/metabolism ; Male ; Mesentery/drug effects ; Mesentery/metabolism ; Muscle Contraction/drug effects ; RNA, Messenger/metabolism ; Receptors, Epoprostenol/metabolism ; Receptors, Prostaglandin E/metabolism ; Receptors, Prostaglandin E, EP4 Subtype ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Prostaglandin E(2) couples through EP(4) prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines.
Autorzy:
Dey I; Departments of Microbiology and Infectious Diseases, Health Sciences Centre, University of Calgary, AB, Canada.
Giembycz MA
Chadee K
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2009 Feb; Vol. 156 (3), pp. 475-85. Date of Electronic Publication: 2009 Jan 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dinoprostone/*metabolism
Epithelial Cells/*metabolism
Interleukin-8/*biosynthesis
Receptors, Prostaglandin E/*metabolism
Blotting, Western ; Caco-2 Cells ; Cell Membrane/metabolism ; Dinoprostone/agonists ; Dinoprostone/antagonists & inhibitors ; Dinoprostone/genetics ; Humans ; Ligands ; Radioligand Assay ; Receptors, Prostaglandin E/agonists ; Receptors, Prostaglandin E/antagonists & inhibitors ; Receptors, Prostaglandin E/genetics ; Receptors, Prostaglandin E, EP4 Subtype ; Reverse Transcriptase Polymerase Chain Reaction ; Transfection ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism.
Autorzy:
Guindon J; Neuroscience and Behavior Program, Department of Psychology, University of Georgia, Athens, GA, USA. />Hohmann AG
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2008 Apr; Vol. 153 (7), pp. 1341-3. Date of Electronic Publication: 2008 Feb 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Arachidonic Acids/*metabolism
Cyclooxygenase 2/*metabolism
Dinoprostone/*analogs & derivatives
Dinoprostone/*metabolism
Glycerides/*metabolism
Animals ; Dinoprostone/biosynthesis ; Endocannabinoids ; Homeostasis/physiology ; Humans ; Oxidation-Reduction ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin-ethanolamides) in the feline iris.
Autorzy:
Woodward DF; Department of Biological Sciences, Allergan, Inc., Irvine, CA 92612, USA. woodward_ />Krauss AH
Wang JW
Protzman CE
Nieves AL
Liang Y
Donde Y
Burk RM
Landsverk K
Struble C
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2007 Feb; Vol. 150 (3), pp. 342-52. Date of Electronic Publication: 2006 Dec 18.
Typ publikacji:
Journal Article
MeSH Terms:
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Dinoprost/*analogs & derivatives
Dinoprostone/*analogs & derivatives
Dinoprostone/*pharmacology
Iris/*drug effects
Oxazoles/*pharmacology
Animals ; Cats ; Dinoprost/pharmacology ; Dinoprost/physiology ; Dinoprostone/physiology ; Dose-Response Relationship, Drug ; In Vitro Techniques ; Receptors, Prostaglandin/drug effects ; Recombinant Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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