Temat: "Dipeptidyl-Peptidase IV Inhibitors" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.
Autorzy:: Wang K; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Zhang Z; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Hang J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.
Liu J; Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Guo F; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Peking University, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Ding Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Li M; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Nie Q; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Lin J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Zhuo Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Sun L; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Luo X; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Zhong Q; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.
Ye C; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Yun C; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Zhang Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Wang J; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Peking University, Beijing, China.
Bao R; Center of Infectious Diseases, Division of Infectious Diseases in State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Pang Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.
Wang G; Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Gonzalez FJ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Lei X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Peking University, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Qiao J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Beijing Advanced Innovation Center for Genomics, Beijing, China.
Jiang C; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.; Center of Basic Medical Research, Institute of Medical Innovation and Research, Third Hospital, Peking University, Beijing, China.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Aug 04; Vol. 381 (6657), pp. eadd5787. Date of Electronic Publication: 2023 Aug 04.
Typ publikacji:: Journal Article
MeSH Terms:: Bacteroides*/drug effects
Bacteroides*/enzymology
Bacteroides*/genetics
Diabetes Mellitus, Type 2*/enzymology
Diabetes Mellitus, Type 2*/microbiology
Dipeptidyl Peptidase 4*/metabolism
Dipeptidyl-Peptidase IV Inhibitors*/pharmacology
Dipeptidyl-Peptidase IV Inhibitors*/therapeutic use
Gastrointestinal Microbiome*
Host Microbial Interactions*
Hypoglycemic Agents*/pharmacology
Hypoglycemic Agents*/therapeutic use
Animals ; Humans ; Mice ; Feces/microbiology ; Glucagon-Like Peptide 1/metabolism ; Glucose/metabolism ; Isoenzymes/metabolism ; Sitagliptin Phosphate/pharmacology ; Sitagliptin Phosphate/therapeutic use

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Skocz do pozycji: 2.

Tytuł:: Therapeutic Perspectives of CD26 Inhibitors in Imune-Mediated Diseases.
Autorzy:: Hu X; Medical Research Center, People's Hospital of Longhua, Shenzhen 518109, China.
Wang X; Medical Research Center, People's Hospital of Longhua, Shenzhen 518109, China.
Xue X; Medical Research Center, People's Hospital of Longhua, Shenzhen 518109, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Jul 14; Vol. 27 (14). Date of Electronic Publication: 2022 Jul 14.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Dipeptidyl Peptidase 4*/metabolism
Dipeptidyl-Peptidase IV Inhibitors*/pharmacology
Dipeptidyl-Peptidase IV Inhibitors*/therapeutic use
Glucagon-Like Peptide 1/pharmacology ; Incretins/pharmacology ; Killer Cells, Natural ; T-Lymphocytes

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Skocz do pozycji: 3.

Tytuł:: Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic Activities.
Autorzy:: Mahrosh HS; Department of Biochemistry, Government College University Faisalabad, Pakistan.
Mehmood R; Department of Biochemistry, Government College University Faisalabad, Pakistan.
Bukhari SA; Department of Biochemistry, Government College University Faisalabad, Pakistan.
Afzal G; Department of Zoology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Arif R; Department of Biochemistry, Government College University Faisalabad, Pakistan.; Pokaż więcej
Źródło:: BioMed research international [Biomed Res Int] 2021 Mar 08; Vol. 2021, pp. 5550180. Date of Electronic Publication: 2021 Mar 08 (Print Publication: 2021).
Typ publikacji:: Journal Article
MeSH Terms:: Glucose Transporter Type 2*/antagonists & inhibitors
Glucose Transporter Type 2*/chemistry
Sodium-Glucose Transporter 1*/antagonists & inhibitors
Sodium-Glucose Transporter 1*/chemistry
Dipeptidyl Peptidase 4/*chemistry
Dipeptidyl-Peptidase IV Inhibitors/*chemistry
Hypoglycemic Agents/*chemistry
Momordica charantia/*chemistry
Peptides/*chemistry
Plant Proteins/*chemistry
Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Humans ; Hypoglycemic Agents/therapeutic use ; Peptides/therapeutic use

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Skocz do pozycji: 4.

Tytuł:: Pyrazole Incorporated New Thiosemicarbazones: Design, Synthesis and Investigation of DPP-4 Inhibitory Effects.
Autorzy:: Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Soybir H; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Görgülü Ş; Medicinal Plant, Drug and Scientific Research and Application Center, Anadolu University, 26470 Eskişehir, Turkey.
Cantürk Z; Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 Oct 28; Vol. 25 (21). Date of Electronic Publication: 2020 Oct 28.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Design*
Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*chemical synthesis
Dipeptidyl-Peptidase IV Inhibitors/*pharmacology
Pyrazoles/*chemistry
Thiosemicarbazones/*chemical synthesis
Thiosemicarbazones/*pharmacology
Chemistry Techniques, Synthetic ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl-Peptidase IV Inhibitors/chemistry ; Dipeptidyl-Peptidase IV Inhibitors/metabolism ; Molecular Docking Simulation ; Protein Conformation ; Thiosemicarbazones/chemistry ; Thiosemicarbazones/metabolism

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Skocz do pozycji: 5.

Tytuł:: Identification of Dipeptidyl Peptidase-4 and α-Amylase Inhibitors from Melicope glabra (Blume) T. G. Hartley (Rutaceae) Using Liquid Chromatography Tandem Mass Spectrometry, In Vitro and In Silico Methods.
Autorzy:: Quek A; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia.
Kassim NK; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia.; Integrated Chemical BioPhysics Research, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia.
Ismail A; Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia.
Latif MAM; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia.
Shaari K; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia.; Natural Medicines & Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia.
Tan DC; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia.
Lim PC; Faculty of Pharmacy, Mahsa University, Bandar Saujana Putra, Jenjarom, Selangor 42610, Malaysia.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 Dec 22; Vol. 26 (1). Date of Electronic Publication: 2020 Dec 22.
Typ publikacji:: Journal Article
MeSH Terms:: Molecular Docking Simulation*
Molecular Dynamics Simulation*
Dipeptidyl Peptidase 4/*chemistry
Dipeptidyl-Peptidase IV Inhibitors/*chemistry
Glycoside Hydrolase Inhibitors/*chemistry
Plant Extracts/*chemistry
Rutaceae/*chemistry
alpha-Amylases/*chemistry
Chromatography, Liquid ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors/pharmacology ; Phytochemicals/chemistry ; Plant Extracts/pharmacology ; Tandem Mass Spectrometry

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Skocz do pozycji: 6.

Tytuł:: Knockdown of DPP4 promotes the proliferation and the activation of the CREB/aromatase pathway in ovarian granulosa cells.
Autorzy:: Lin L; Center for Reproductive Medicine, Shantou Central Hospital, Shantou, Guangdong 515041, P.R. China.
Wang L; Center for Reproductive Medicine, Shantou Central Hospital, Shantou, Guangdong 515041, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2022 Feb; Vol. 25 (2). Date of Electronic Publication: 2022 Jan 11.
Typ publikacji:: Journal Article
MeSH Terms:: Aromatase/*metabolism
Cyclic AMP Response Element-Binding Protein/*metabolism
Dipeptidyl Peptidase 4/*genetics
Dipeptidyl Peptidase 4/*metabolism
Granulosa Cells/*metabolism
Animals ; Aromatase/genetics ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Survival/genetics ; Cholesterol Side-Chain Cleavage Enzyme/genetics ; Cholesterol Side-Chain Cleavage Enzyme/metabolism ; Cyclic AMP Response Element-Binding Protein/genetics ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Disease Models, Animal ; Female ; Humans ; Polycystic Ovary Syndrome/genetics ; Polycystic Ovary Syndrome/metabolism ; Rats, Sprague-Dawley ; Serum Albumin, Bovine/pharmacology ; Signal Transduction/genetics ; Sitagliptin Phosphate/pharmacology ; Up-Regulation ; Rats

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Skocz do pozycji: 7.

Tytuł:: Simultaneous Natural Deep Eutectic Solvent-Based Ultrasonic-Assisted Extraction of Bioactive Compounds of Cinnamon Bark and Sappan Wood as a Dipeptidyl Peptidase IV Inhibitor.
Autorzy:: Ahmad I; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, East Kalimantan 75119, Indonesia.
Arifianti AE; Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia.
Sakti AS; Graduate Program of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia.
Saputri FC; Graduate Program of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia.
Mun'im A; Graduate Program of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia.; Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 Aug 23; Vol. 25 (17). Date of Electronic Publication: 2020 Aug 23.
Typ publikacji:: Journal Article
MeSH Terms:: Dipeptidyl-Peptidase IV Inhibitors*/chemistry
Dipeptidyl-Peptidase IV Inhibitors*/isolation & purification
Molecular Docking Simulation*
Ultrasonic Waves*
Cinnamomum zeylanicum/*chemistry
Dipeptidyl Peptidase 4/*chemistry
Plant Bark/*chemistry
Wood/*chemistry

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Skocz do pozycji: 8.

Tytuł:: Interrelationship between 2019-nCov receptor DPP4 and diabetes mellitus targets based on protein interaction network.
Autorzy:: Gao Q; Affiliated Hospital of Shaoxing University of Endocrine and Metabolism Department, Zhejiang, China. .
Zhang W; Affiliated Hospital of Shaoxing University of Endocrine and Metabolism Department, Zhejiang, China.
Li T; Affiliated Hospital of Shaoxing University of Endocrine and Metabolism Department, Zhejiang, China.
Yang G; Affiliated Hospital of Shaoxing University of Endocrine and Metabolism Department, Zhejiang, China.
Zhu W; Affiliated Hospital of Shaoxing University of Endocrine and Metabolism Department, Zhejiang, China.
Chen N; Affiliated Hospital of Shaoxing University of Endocrine and Metabolism Department, Zhejiang, China.
Jin H; Affiliated Hospital of Shaoxing University of Endocrine and Metabolism Department, Zhejiang, China.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Jan 07; Vol. 12 (1), pp. 188. Date of Electronic Publication: 2022 Jan 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Protein Interaction Maps*/drug effects
COVID-19/*metabolism
Diabetes Mellitus, Type 2/*metabolism
Dipeptidyl Peptidase 4/*metabolism
SARS-CoV-2/*physiology
COVID-19/complications ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Drug Discovery ; Humans ; COVID-19 Drug Treatment

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Skocz do pozycji: 9.

Tytuł:: Model Optimization and In Silico Analysis of Potential Dipeptidyl Peptidase IV Antagonists from GC-MS Identified Compounds in Nauclea latifolia Leaf Extracts.
Autorzy:: Iheagwam FN; Department of Biochemistry, Covenant University, PMB 1023, Ota 112212, Ogun State, Nigeria.; Covenant University Public Health and Wellness Research Cluster (CUPHWERC), Covenant University, PMB 1023, Ota 112212, Ogun State, Nigeria.
Ogunlana OO; Department of Biochemistry, Covenant University, PMB 1023, Ota 112212, Ogun State, Nigeria.; Covenant University Public Health and Wellness Research Cluster (CUPHWERC), Covenant University, PMB 1023, Ota 112212, Ogun State, Nigeria.
Chinedu SN; Department of Biochemistry, Covenant University, PMB 1023, Ota 112212, Ogun State, Nigeria.; Covenant University Public Health and Wellness Research Cluster (CUPHWERC), Covenant University, PMB 1023, Ota 112212, Ogun State, Nigeria.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 Nov 25; Vol. 20 (23). Date of Electronic Publication: 2019 Nov 25.
Typ publikacji:: Journal Article
MeSH Terms:: Dipeptidyl Peptidase 4/*chemistry
Dipeptidyl-Peptidase IV Inhibitors/*pharmacology
Molecular Docking Simulation/*standards
Plant Extracts/*pharmacology
Plant Leaves/*chemistry
Rubiaceae/*chemistry
Dipeptidyl-Peptidase IV Inhibitors/chemistry ; Gas Chromatography-Mass Spectrometry ; Humans ; Models, Molecular ; Plant Extracts/chemistry ; Protein Conformation

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Skocz do pozycji: 10.

Tytuł:: Natural phenolic compounds potentiate hypoglycemia via inhibition of Dipeptidyl peptidase IV.
Autorzy:: Huang PK; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, 97401, Taiwan.
Lin SR; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, 97401, Taiwan.
Chang CH; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, 97401, Taiwan.
Tsai MJ; Neural regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital, Taipei, 11217, Taiwan.
Lee DN; Department of Biotechnology and Animal Science, National Ilan University, Ilan, 26047, Taiwan.
Weng CF; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, 97401, Taiwan. .; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Oct 30; Vol. 9 (1), pp. 15585. Date of Electronic Publication: 2019 Oct 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*pharmacology
Hypoglycemic Agents/*pharmacology
Phenol/*pharmacology
Animals ; Caco-2 Cells ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Dipeptidyl Peptidase 4/biosynthesis ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl-Peptidase IV Inhibitors/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Hypoglycemic Agents/metabolism ; Male ; Mice ; Molecular Docking Simulation ; Phenol/metabolism ; Phosphorylation/drug effects ; Protein Conformation

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Skocz do pozycji: 11.

Tytuł:: First report of chromenyl derivatives from spineless marine cuttlefish Sepiella inermis: Prospective antihyperglycemic agents attenuate serine protease dipeptidyl peptidase-IV.
Autorzy:: Krishnan S; Marine Biotechnology Division, Central Marine Fisheries Research Institute, Cochin, India.; Department of Biosciences, Mangalore University, Mangalagangothri, India.
Chakraborty K; Marine Biotechnology Division, Central Marine Fisheries Research Institute, Cochin, India.
Joy M; Marine Biotechnology Division, Central Marine Fisheries Research Institute, Cochin, India.; Pokaż więcej
Źródło:: Journal of food biochemistry [J Food Biochem] 2019 May; Vol. 43 (5), pp. e12824. Date of Electronic Publication: 2019 Mar 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antioxidants/*pharmacology
Decapodiformes/*chemistry
Dipeptidyl Peptidase 4/*drug effects
Dipeptidyl-Peptidase IV Inhibitors/*pharmacology
Hypoglycemic Agents/*pharmacology
Animals ; Antioxidants/isolation & purification ; Benzopyrans/isolation & purification ; Benzopyrans/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/isolation & purification ; Hypoglycemic Agents/isolation & purification ; Molecular Docking Simulation

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Skocz do pozycji: 12.

Tytuł:: The role of Dipeptidyl Peptidase-4 in cutaneous disease.
Autorzy:: Patel PM; Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA.
Jones VA; Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA.
Kridin K; Department of Dermatology, University of Lübeck, Lübeck, Germany.
Amber KT; Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA.; Pokaż więcej
Źródło:: Experimental dermatology [Exp Dermatol] 2021 Mar; Vol. 30 (3), pp. 304-318. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Dipeptidyl Peptidase 4/*immunology
Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*adverse effects
Skin Diseases/*enzymology
Skin Diseases/*etiology
Animals ; Biomarkers, Tumor/metabolism ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/immunology ; Dipeptidyl Peptidase 4/genetics ; Humans ; Immunity ; Keratinocytes/metabolism ; Leishmaniasis, Cutaneous/enzymology ; Lymphocytes/metabolism ; Lymphoma, T-Cell, Cutaneous/enzymology ; Pemphigoid, Benign Mucous Membrane/chemically induced ; Pemphigoid, Bullous/chemically induced ; Psoriasis/enzymology ; Skin Neoplasms/enzymology ; Wound Healing

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Skocz do pozycji: 13.

Tytuł:: Magnetic ligand fishing using immobilized DPP-IV for identification of antidiabetic ligands in lingonberry extract.
Autorzy:: Lima RCL; NOFIMA AS, Ås, Norway.
Böcker U; NOFIMA AS, Ås, Norway.
McDougall GJ; Plant Biochemistry and Food Quality Group, Environmental and Biochemical Sciences Department, The James Hutton Institute, Invergowrie, Dundee, Scotland, United Kingdom.
Allwood JW; Plant Biochemistry and Food Quality Group, Environmental and Biochemical Sciences Department, The James Hutton Institute, Invergowrie, Dundee, Scotland, United Kingdom.
Afseth NK; NOFIMA AS, Ås, Norway.
Wubshet SG; NOFIMA AS, Ås, Norway.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2021 Feb 22; Vol. 16 (2), pp. e0247329. Date of Electronic Publication: 2021 Feb 22 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*pharmacology
Hypoglycemic Agents/*pharmacology
Plant Extracts/*pharmacology
Vaccinium vitis-idaea/*chemistry
Animals ; Anthocyanins/pharmacology ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Galactosides/pharmacology ; Glucosides/pharmacology ; Humans ; Ligands ; Magnetic Phenomena ; Magnetics/methods ; Swine

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Skocz do pozycji: 14.

Tytuł:: Macrocarpal C isolated from Eucalyptus globulus inhibits dipeptidyl peptidase 4 in an aggregated form.
Autorzy:: Kato E; a Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture , Hokkaido University , Kita-ku , Hokkaido , Japan Sapporo.
Kawakami K; a Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture , Hokkaido University , Kita-ku , Hokkaido , Japan Sapporo.
Kawabata J; a Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture , Hokkaido University , Kita-ku , Hokkaido , Japan Sapporo.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2018 Dec; Vol. 33 (1), pp. 106-109.
Typ publikacji:: Journal Article
MeSH Terms:: Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*pharmacology
Eucalyptus/*chemistry
Phloroglucinol/*analogs & derivatives
Sesquiterpenes/*isolation & purification
Sesquiterpenes/*pharmacology
Dipeptidyl-Peptidase IV Inhibitors/chemistry ; Dipeptidyl-Peptidase IV Inhibitors/isolation & purification ; Dose-Response Relationship, Drug ; Humans ; Molecular Conformation ; Phloroglucinol/chemistry ; Phloroglucinol/isolation & purification ; Phloroglucinol/pharmacology ; Sesquiterpenes/chemistry ; Structure-Activity Relationship

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Skocz do pozycji: 15.

Tytuł:: Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4.
Autorzy:: Huang PK; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan. .
Lin SR; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan. .
Riyaphan J; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan. .
Fu YS; Departmental of Biomedical Science and Environmental Biology, Kaoshiung Medical University, Kaoshiung 80708, Taiwan. .
Weng CF; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 Jan 27; Vol. 20 (3). Date of Electronic Publication: 2019 Jan 27.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Experimental/*drug therapy
Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*administration & dosage
Diterpenes, Clerodane/*administration & dosage
Hypoglycemia/*drug therapy
Polyalthia/*chemistry
Animals ; Caco-2 Cells ; Cell Line ; Diabetes Mellitus, Experimental/metabolism ; Diet, High-Fat/adverse effects ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Diterpenes, Clerodane/pharmacology ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemia/metabolism ; Insulin-Secreting Cells/cytology ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Lipopolysaccharides/adverse effects ; Male ; Mice ; Monocytes/cytology ; Monocytes/drug effects ; Monocytes/metabolism ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology ; Rats ; Signal Transduction/drug effects

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Skocz do pozycji: 16.

Tytuł:: Features of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from dietary proteins.
Autorzy:: Nongonierma AB; Department of Biological Sciences and Food for Health Ireland (FHI), University of Limerick, Limerick, Ireland.
FitzGerald RJ; Department of Biological Sciences and Food for Health Ireland (FHI), University of Limerick, Limerick, Ireland.; Pokaż więcej
Źródło:: Journal of food biochemistry [J Food Biochem] 2019 Jan; Vol. 43 (1), pp. e12451. Date of Electronic Publication: 2017 Nov 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Dietary Proteins/*chemistry
Dipeptidyl Peptidase 4/*drug effects
Dipeptidyl-Peptidase IV Inhibitors/*pharmacology
Peptides/*pharmacology
Animals ; Dietary Proteins/metabolism ; Dipeptidyl Peptidase 4/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/isolation & purification ; Humans ; Peptides/chemistry ; Peptides/isolation & purification ; Proteolysis ; Structure-Activity Relationship ; Substrate Specificity

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Skocz do pozycji: 17.

Tytuł:: Risk of heart failure hospitalization among users of dipeptidyl peptidase-4 inhibitors compared to glucagon-like peptide-1 receptor agonists.
Autorzy:: Dawwas GK; Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, PO Box 100495, Gainesville, FL, 32610, USA.
Smith SM; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, PO Box 100486, Gainesville, FL, 32610, USA.; Department of Community Health and Family Medicine, College of Medicine, University of Florida, PO Box 100237, Gainesville, FL, 32610, USA.
Park H; Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, PO Box 100495, Gainesville, FL, 32610, USA. .; Pokaż więcej
Źródło:: Cardiovascular diabetology [Cardiovasc Diabetol] 2018 Jul 17; Vol. 17 (1), pp. 102. Date of Electronic Publication: 2018 Jul 17.
Typ publikacji:: Comparative Study; Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms:: Patient Admission*
Diabetes Mellitus, Type 2/*drug therapy
Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*therapeutic use
Glucagon-Like Peptide-1 Receptor/*agonists
Heart Failure/*etiology
Incretins/*therapeutic use
Adult ; Aged ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/enzymology ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Female ; Glucagon-Like Peptide-1 Receptor/metabolism ; Heart Failure/diagnosis ; Heart Failure/prevention & control ; Humans ; Incretins/adverse effects ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome

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Skocz do pozycji: 18.

Tytuł:: Dipeptidyl peptidase 4 promotes peritoneal fibrosis and its inhibitions prevent failure of peritoneal dialysis.
Autorzy:: Li YC; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Sung PH; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Yang YH; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan.; Health Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan.; School of Medicine, Chang Gung University, Taoyuan, Taiwan.; Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.
Chiang JY; Department of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan.; Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yip HK; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. .; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. .; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. .; Department of Nursing, Asia University, Taichung, Taiwan. .; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. .; Division of Cardiology, Department of Internal Medicine, Xiamen Chang Gung Hospital, Xiamen, Fujian, China. .
Yang CC; Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2021 Jan 29; Vol. 4 (1), pp. 144. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji:: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms:: Peritoneal Dialysis*/adverse effects
Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*therapeutic use
Kidney Failure, Chronic/*therapy
Peritoneal Fibrosis/*prevention & control
Peritoneum/*drug effects
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Cell Line ; Dipeptidyl Peptidase 4/genetics ; Disease Models, Animal ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Humans ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/enzymology ; Male ; Middle Aged ; Mutation, Missense ; Peritoneal Fibrosis/enzymology ; Peritoneal Fibrosis/pathology ; Peritoneum/enzymology ; Peritoneum/pathology ; Rats, Inbred F344 ; Rats, Transgenic ; Retrospective Studies ; Taiwan ; Treatment Outcome ; Young Adult ; Rats

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Skocz do pozycji: 19.

Tytuł:: Flavonol Glycosides: In Vitro Inhibition of DPPIV, Aldose Reductase and Combating Oxidative Stress are Potential Mechanisms for Mediating the Antidiabetic Activity of Cleome droserifolia .
Autorzy:: Abdel Motaal A; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Salem HH; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.; College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.
Almaghaslah D; Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.
Alsayari A; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.
Bin Muhsinah A; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.
Alfaifi MY; Department of Biology, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia.
Elbehairi SEI; Department of Biology, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia.; Cell Culture Laboratory, Egyptian Organization for Biological Products and Vaccines, VACSERA Holding Company, Giza 22311, Egypt.
Shati AA; Department of Biology, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia.
El-Askary H; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 Dec 11; Vol. 25 (24). Date of Electronic Publication: 2020 Dec 11.
Typ publikacji:: Journal Article
MeSH Terms:: Dipeptidyl Peptidase 4/*chemistry
Dipeptidyl-Peptidase IV Inhibitors/*chemistry
Glycosides/*pharmacology
Aldehyde Reductase/chemistry ; Aldehyde Reductase/metabolism ; Antioxidants/chemistry ; Biphenyl Compounds/chemistry ; Chemistry, Pharmaceutical/methods ; Chromatography, High Pressure Liquid ; Cleome ; Drug Design ; Free Radical Scavengers ; Humans ; Hypoglycemic Agents ; In Vitro Techniques ; Inhibitory Concentration 50 ; Magnetic Resonance Spectroscopy ; Models, Chemical ; Oxidative Stress ; Picrates/chemistry ; Vildagliptin/pharmacology ; alpha-Amylases/chemistry ; alpha-Glucosidases/metabolism

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Tytuł:: Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression.
Autorzy:: Lee M; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Shin E; Institute of Endocrine Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Bae J; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Cho Y; Department of Internal Medicine, Inha University School of Medicine, Incheon, Republic of Korea.
Lee JY; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Lee YH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Lee BW; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kang ES; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Cha BS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. .; Institute of Endocrine Research, Yonsei University College of Medicine, Seoul, Republic of Korea. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Nov 10; Vol. 10 (1), pp. 19429. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*therapeutic use
Hypoglycemic Agents/*therapeutic use
Non-alcoholic Fatty Liver Disease/*metabolism
Non-alcoholic Fatty Liver Disease/*prevention & control
Animals ; Apoptosis/drug effects ; Body Weight/drug effects ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Signal Transduction/drug effects

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