Temat: "Diphosphotransferases" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Assay Development and Identification of the First Plasmodium falciparum 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Inhibitors.
Autorzy:: Hoarau M; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani 12120, Thailand.
Suwanakitti N; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani 12120, Thailand.
Varatthan T; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani 12120, Thailand.
Thiabma R; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani 12120, Thailand.
Rattanajak R; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani 12120, Thailand.
Charoensetakul N; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani 12120, Thailand.
Redman EK; Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Khotavivattana T; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Vilaivan T; Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Yuthavong Y; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani 12120, Thailand.
Kamchonwongpaisan S; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani 12120, Thailand.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 May 30; Vol. 27 (11). Date of Electronic Publication: 2022 May 30.
Typ publikacji:: Journal Article
MeSH Terms:: Antimalarials*/chemistry
Diphosphotransferases*/antagonists & inhibitors
Plasmodium falciparum*/drug effects
Humans ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Molecular Docking Simulation

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 2.

Tytuł:: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.
Autorzy:: Chitnumsub P; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
Jaruwat A; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
Talawanich Y; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
Noytanom K; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
Liwnaree B; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
Poen S; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
Yuthavong Y; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2020 Aug; Vol. 287 (15), pp. 3273-3297. Date of Electronic Publication: 2020 Jan 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mutation*
Dihydropteroate Synthase/*chemistry
Diphosphotransferases/*chemistry
Drug Resistance/*genetics
Malaria, Falciparum/*drug therapy
Plasmodium falciparum/*drug effects
Plasmodium falciparum/*enzymology
Amino Acid Sequence ; Antimalarials/pharmacology ; Catalytic Domain ; Crystallography, X-Ray ; Dihydropteroate Synthase/metabolism ; Diphosphotransferases/metabolism ; Humans ; Malaria, Falciparum/parasitology ; Protein Conformation ; Sequence Homology

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 3.

Tytuł:: Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK.
Autorzy:: Chhabra S; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Barlow N
Dolezal O
Hattarki MK
Newman J
Peat TS
Graham B
Swarbrick JD; Pokaż więcej
Źródło:: PloS one [PLoS One] 2013; Vol. 8 (4), pp. e59535. Date of Electronic Publication: 2013 Apr 02.
Typ publikacji:: Journal Article
MeSH Terms:: Biosynthetic Pathways/*drug effects
Diphosphotransferases/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Folic Acid/*biosynthesis
Guanine/*analogs & derivatives
Guanine/*pharmacology
Binding Sites ; Diphosphotransferases/chemistry ; Diphosphotransferases/metabolism ; Drug Design ; Enzyme Inhibitors/chemistry ; Guanine/chemistry ; Ligands ; Models, Molecular ; Molecular Conformation ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Thermodynamics

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 4.

Tytuł:: Crystal structure of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase•dihydropteroate synthase bifunctional enzyme from Francisella tularensis.
Autorzy:: Pemble CW 4th; Department of Structural Biology, St. Jude Children's Research Hospital, and Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.
Mehta PK
Mehra S
Li Z
Nourse A
Lee RE
White SW; Pokaż więcej
Źródło:: PloS one [PLoS One] 2010 Nov 30; Vol. 5 (11), pp. e14165. Date of Electronic Publication: 2010 Nov 30.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Dihydropteroate Synthase/*chemistry
Diphosphotransferases/*chemistry
Francisella tularensis/*enzymology
Multienzyme Complexes/*chemistry
Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Biocatalysis ; Catalytic Domain ; Crystallography, X-Ray ; Dihydropteroate Synthase/genetics ; Dihydropteroate Synthase/metabolism ; Diphosphotransferases/genetics ; Diphosphotransferases/metabolism ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Models, Molecular ; Molecular Sequence Data ; Molecular Structure ; Multienzyme Complexes/genetics ; Multienzyme Complexes/metabolism ; Protein Binding ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Sequence Homology, Amino Acid ; Substrate Specificity

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 5.

Tytuł:: Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor.
Autorzy:: Chhabra S; Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Dolezal O
Collins BM
Newman J
Simpson JS
Macreadie IG
Fernley R
Peat TS
Swarbrick JD; Pokaż więcej
Źródło:: PloS one [PLoS One] 2012; Vol. 7 (1), pp. e29444. Date of Electronic Publication: 2012 Jan 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Bacterial Proteins/*chemistry
Diphosphotransferases/*chemistry
Staphylococcus aureus/*enzymology
Bacterial Proteins/metabolism ; Diphosphotransferases/metabolism ; Magnetic Resonance Spectroscopy ; Pterins/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 6.

Tytuł:: Structure and activity of Yersinia pestis 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as a novel target for the development of antiplague therapeutics.
Autorzy:: Blaszczyk J; Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Li Y
Cherry S
Alexandratos J
Wu Y
Shaw G
Tropea JE
Waugh DS
Yan H
Ji X; Pokaż więcej
Źródło:: Acta crystallographica. Section D, Biological crystallography [Acta Crystallogr D Biol Crystallogr] 2007 Nov; Vol. 63 (Pt 11), pp. 1169-77. Date of Electronic Publication: 2007 Oct 17.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms:: Diphosphotransferases/*chemistry
Enzyme Inhibitors/*pharmacology
Plague/*drug therapy
Yersinia pestis/*enzymology
Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/chemistry ; Amino Acid Substitution ; Animals ; Binding Sites ; Catalysis ; Crystallography, X-Ray ; Dimerization ; Diphosphotransferases/antagonists & inhibitors ; Diphosphotransferases/genetics ; Drug Design ; Enzyme Inhibitors/therapeutic use ; Humans ; Kinetics ; Models, Molecular ; Plague/microbiology ; Protein Conformation ; Pterins/chemistry ; Recombinant Proteins/chemistry ; Thermodynamics ; Yersinia pestis/drug effects

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 7.

Tytuł:: The multifunctional folic acid synthesis fas gene of Pneumocystis carinii encodes dihydroneopterin aldolase, hydroxymethyldihydropterin pyrophosphokinase and dihydropteroate synthase.
Autorzy:: Volpe F; Department of Molecular Sciences, Wellcome Research Laboratories, Beckenham, England.
Ballantine SP
Delves CJ; Pokaż więcej
Źródło:: European journal of biochemistry [Eur J Biochem] 1993 Sep 01; Vol. 216 (2), pp. 449-58.
Typ publikacji:: Journal Article
MeSH Terms:: Diphosphotransferases*
Genes, Fungal*
Aldehyde-Lyases/*genetics
Dihydropteroate Synthase/*genetics
Folic Acid/*biosynthesis
Phosphotransferases/*genetics
Pneumocystis/*genetics
Animals ; Baculoviridae/genetics ; Base Sequence ; Cells, Cultured ; Cloning, Molecular ; DNA, Fungal ; Molecular Sequence Data ; Moths ; Open Reading Frames ; Pneumocystis/enzymology ; Pneumocystis/metabolism ; Rats ; Rats, Sprague-Dawley

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 8.

Tytuł:: Serine codon-usage bias in deep phylogenomics: pancrustacean relationships as a case study.
Autorzy:: Rota-Stabelli O; Department of Biology, The National University of Ireland, Maynooth, Co. Kildare, Ireland. />Lartillot N
Philippe H
Pisani D; Pokaż więcej
Źródło:: Systematic biology [Syst Biol] 2013 Jan 01; Vol. 62 (1), pp. 121-33. Date of Electronic Publication: 2012 Sep 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genomics*
Phylogeny*
Codon/*genetics
Crustacea/*classification
Crustacea/*genetics
Serine/*genetics
Amino Acids/genetics ; Animals ; Arthropods/classification ; Arthropods/genetics ; Bias ; Diphosphotransferases/genetics ; Models, Genetic

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 9.

Tytuł:: Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine.
Autorzy:: Brooks DR; Department of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology, England.
Wang P
Read M
Watkins WM
Sims PF
Hyde JE; Pokaż więcej
Źródło:: European journal of biochemistry [Eur J Biochem] 1994 Sep 01; Vol. 224 (2), pp. 397-405.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Variation*
Dihydropteroate Synthase/*genetics
Diphosphotransferases/*genetics
Plasmodium falciparum/*enzymology
Plasmodium falciparum/*genetics
Sulfadoxine/*pharmacology
Amino Acid Sequence ; Animals ; Base Sequence ; Chromosome Mapping ; Consensus Sequence ; DNA Primers ; DNA, Protozoan/analysis ; DNA, Protozoan/chemistry ; Drug Resistance ; Humans ; Malaria, Falciparum/parasitology ; Molecular Sequence Data ; Mutation ; Sequence Homology, Amino Acid

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 10.

Informacja:: Dostęp do tej pozycji wymaga zalogowania się.

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 11.

Informacja:: Dostęp do tej pozycji wymaga zalogowania się.

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 12.

Informacja:: Dostęp do tej pozycji wymaga zalogowania się.

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 13.

Informacja:: Dostęp do tej pozycji wymaga zalogowania się.

Czasopismo naukowe

na półce

Szczegóły

Informacja

Wyszukujesz frazę ""Diphosphotransferases"" wg kryterium: Temat

Źródło danych

Ogranicz do:

Ogranicz do bazy

Typ dokumentu

Temat

Wydawca

Publikacja

Język