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Wyszukujesz frazę ""Disease Models, Animal"" wg kryterium: Temat


Tytuł :
Exploration of zebrafish larvae as an alternative whole-animal model for nephrotoxicity testing.
Autorzy :
Bauer B; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany.
Liedtke D; Institute of Human Genetics, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Jarzina S; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany.
Stammler E; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany.
Kreisel K; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany.
Lalomia V; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany.
Diefenbacher M; Chair of Biochemistry and Molecular Biology, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Klopocki E; Institute of Human Genetics, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Mally A; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 15; Vol. 344, pp. 69-81. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Zebrafish*
Cadherins/*metabolism
Toxicity Tests/*methods
Zebrafish Proteins/*metabolism
Animals ; Biomarkers/metabolism ; Cadherins/genetics ; Central Nervous System ; Gene Expression Regulation, Developmental/drug effects ; Kidney/drug effects ; Larva ; Zebrafish Proteins/genetics
Czasopismo naukowe
Tytuł :
Animal models for SARS-CoV-2.
Autorzy :
Lee CY; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.
Lowen AC; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States; Emory-UGA Center of Excellence for Influenza Research and Surveillance (CEIRS), Atlanta, GA, United States. Electronic address: .
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Źródło :
Current opinion in virology [Curr Opin Virol] 2021 Jun; Vol. 48, pp. 73-81. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19*/drug therapy
COVID-19*/prevention & control
Disease Models, Animal*
Antiviral Agents/*therapeutic use
COVID-19 Vaccines/*administration & dosage
Animals ; Humans
Czasopismo naukowe
Tytuł :
Altered hippocampal function and cytokine levels in a rat model of Gulf War illness.
Autorzy :
Gargas NM; Naval Medical Research Unit Dayton, 2728 Q Street, Area B, Building 837, WPAFB, OH 45433, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Odyssey Systems Consulting Group, Ltd, 201 Edgewater Drive Suite 270, Wakefield, MA 01880, USA.
Ethridge VT; Naval Medical Research Unit Dayton, 2728 Q Street, Area B, Building 837, WPAFB, OH 45433, USA; Oak Ridge Institute for Science and Education, 1299 Bethel Valley Rd, Oak Ridge, TN 37830, USA.
Miklasevich MK; Naval Medical Research Unit Dayton, 2728 Q Street, Area B, Building 837, WPAFB, OH 45433, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA.
Rohan JG; Naval Medical Research Unit Dayton, 2728 Q Street, Area B, Building 837, WPAFB, OH 45433, USA. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jun 01; Vol. 274, pp. 119333. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Cytokines/*metabolism
Hippocampus/*pathology
Inflammation/*complications
Inflammation Mediators/*metabolism
Persian Gulf Syndrome/*pathology
Animals ; Behavior, Animal ; Hippocampus/immunology ; Hippocampus/metabolism ; Long-Term Potentiation ; Male ; Persian Gulf Syndrome/etiology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Autorzy :
Vandyck K; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium. Electronic address: .
Abdelnabi R; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Gupta K; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Jochmans D; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Jekle A; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Deval J; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Misner D; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Bardiot D; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium.
Foo CS; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Liu C; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Ren S; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Beigelman L; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Blatt LM; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Boland S; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium.
Vangeel L; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Dejonghe S; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Chaltin P; Centre for Drug Design and Discovery (CD3), KU Leuven, Gaston Geenslaan 2, 3001 Leuven, Belgium; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium.
Marchand A; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium.
Serebryany V; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Stoycheva A; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Chanda S; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Symons JA; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.
Raboisson P; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium.
Neyts J; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 28; Vol. 555, pp. 134-139. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Amides/*pharmacology
COVID-19/*drug therapy
Coronavirus 3C Proteases/*antagonists & inhibitors
Cysteine Proteinase Inhibitors/*pharmacology
SARS-CoV-2/*drug effects
SARS-CoV-2/*enzymology
Amides/pharmacokinetics ; Animals ; COVID-19/virology ; Cathepsin L/antagonists & inhibitors ; Cell Line ; Cricetinae ; Cysteine Proteinase Inhibitors/pharmacokinetics ; Female ; Humans ; Inhibitory Concentration 50 ; Male ; Mesocricetus/virology ; Reproducibility of Results ; SARS-CoV-2/growth & development ; Serine Endopeptidases ; Substrate Specificity ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease.
Autorzy :
Matsui H; Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata, Japan. .; Department of Neuroscience of Disease, Center for Transdisciplinary Research, Niigata University, Niigata, Japan. .
Ito J; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Matsui N; Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata, Japan.
Uechi T; Frontier Science Research Center, University of Miyazaki, Miyazaki, Japan.
Onodera O; Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
Kakita A; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
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Źródło :
Nature communications [Nat Commun] 2021 May 25; Vol. 12 (1), pp. 3101. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
DNA/*genetics
Mitochondria/*genetics
Parkinson Disease/*genetics
Zebrafish/*genetics
Animals ; Animals, Genetically Modified ; Brain/metabolism ; Brain/pathology ; Brain/ultrastructure ; Cell Line, Tumor ; Cell Survival/genetics ; Cytosol/metabolism ; DNA/metabolism ; Endodeoxyribonucleases/genetics ; Endodeoxyribonucleases/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Microscopy, Electron ; Mitochondria/metabolism ; Parkinson Disease/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł :
mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease.
Autorzy :
Cao J; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Choi M; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Guadagnin E; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Soty M; INSERM UMR1213, Université Claude Bernard Lyon 1, Lyon, France.
Silva M; INSERM UMR1213, Université Claude Bernard Lyon 1, Lyon, France.
Verzieux V; INSERM UMR1213, Université Claude Bernard Lyon 1, Lyon, France.
Weisser E; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Markel A; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Zhuo J; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Liang S; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Yin L; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Frassetto A; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Graham AR; Platform, Moderna, Inc, Cambridge, MA, USA.
Burke K; Platform, Moderna, Inc, Cambridge, MA, USA.
Ketova T; Platform, Moderna, Inc, Cambridge, MA, USA.
Mihai C; Platform, Moderna, Inc, Cambridge, MA, USA.
Zalinger Z; Platform, Moderna, Inc, Cambridge, MA, USA.
Levy B; Platform, Moderna, Inc, Cambridge, MA, USA.
Besin G; Platform, Moderna, Inc, Cambridge, MA, USA.
Wolfrom M; Platform, Moderna, Inc, Cambridge, MA, USA.
Tran B; Platform, Moderna, Inc, Cambridge, MA, USA.
Tunkey C; Platform, Moderna, Inc, Cambridge, MA, USA.
Owen E; Platform, Moderna, Inc, Cambridge, MA, USA.
Sarkis J; Platform, Moderna, Inc, Cambridge, MA, USA.
Dousis A; Platform, Moderna, Inc, Cambridge, MA, USA.
Presnyak V; Platform, Moderna, Inc, Cambridge, MA, USA.
Pepin C; Platform, Moderna, Inc, Cambridge, MA, USA.
Zheng W; Platform, Moderna, Inc, Cambridge, MA, USA.
Ci L; Platform, Moderna, Inc, Cambridge, MA, USA.
Hard M; Platform, Moderna, Inc, Cambridge, MA, USA.
Miracco E; Platform, Moderna, Inc, Cambridge, MA, USA.
Rice L; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Nguyen V; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Zimmer M; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Rajarajacholan U; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Finn PF; Rare Diseases, Moderna, Inc, Cambridge, MA, USA.
Mithieux G; INSERM UMR1213, Université Claude Bernard Lyon 1, Lyon, France.
Rajas F; INSERM UMR1213, Université Claude Bernard Lyon 1, Lyon, France.
Martini PGV; Rare Diseases, Moderna, Inc, Cambridge, MA, USA. .
Giangrande PH; Rare Diseases, Moderna, Inc, Cambridge, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 25; Vol. 12 (1), pp. 3090. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Genetic Therapy/*methods
Glucose-6-Phosphatase/*genetics
Glycogen Storage Disease/*therapy
RNA, Messenger/*genetics
Animals ; Cell Line, Tumor ; Cytokines/blood ; Cytokines/metabolism ; Glucose-6-Phosphatase/metabolism ; Glycogen/metabolism ; Glycogen Storage Disease/genetics ; Glycogen Storage Disease/pathology ; HeLa Cells ; Humans ; Liver/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; RNA, Messenger/administration & dosage ; RNA, Messenger/chemistry ; Treatment Outcome ; Triglycerides/metabolism
Czasopismo naukowe
Tytuł :
Cataract-causing allele in CRYAA (Y118D) proceeds through endoplasmic reticulum stress in mouse model.
Autorzy :
Jia ZK; Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Fu CX; Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Wang AL; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310020, China.
Yao K; Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. E-mail:.
Chen XJ; Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310020, China. E-mail: .
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Źródło :
Zoological research [Zool Res] 2021 May 18; Vol. 42 (3), pp. 300-309.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Cataract/*veterinary
Endoplasmic Reticulum Stress/*genetics
alpha-Crystallin A Chain/*metabolism
Alleles ; Animals ; Cataract/genetics ; Mice ; Mutation ; alpha-Crystallin A Chain/genetics
Czasopismo naukowe
Tytuł :
Longitudinal in vivo imaging of acute neuropathology in a monkey model of Ebola virus infection.
Autorzy :
Schreiber-Stainthorp W; Hammoud Laboratory, Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA.
Solomon J; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Lee JH; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA.
Castro M; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA.
Shah S; Hammoud Laboratory, Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA.
Martinez-Orengo N; Hammoud Laboratory, Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA.
Reeder R; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA.
Maric D; Flow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA.
Gross R; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA.
Qin J; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Hagen KR; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA.
Johnson RF; Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA.
Hammoud DA; Hammoud Laboratory, Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 17; Vol. 12 (1), pp. 2855. Date of Electronic Publication: 2021 May 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
Disease Models, Animal*
Fluorodeoxyglucose F18*
Brain/*diagnostic imaging
Hemorrhagic Fever, Ebola/*diagnostic imaging
Positron-Emission Tomography/*methods
Animals ; Blood-Brain Barrier/diagnostic imaging ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/virology ; Brain/metabolism ; Brain/virology ; Cytokines/metabolism ; Ebolavirus/physiology ; Haplorhini ; Hemorrhagic Fever, Ebola/virology ; Host-Pathogen Interactions ; Humans
Czasopismo naukowe
Tytuł :
The implication of transient receptor potential canonical 6 in BDNF-induced mechanical allodynia in rat model of diabetic neuropathic pain.
Autorzy :
Miao B; Department of Gastroenterology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221002, Jiangsu Province, China; Institute of Digestive Diseases, Xuzhou Medical University, 84 West Huaihai Road, Xuzhou 221002, Jiangsu Province, China.
Yin Y; Department of Anesthesiology, Xuzhou Central Hospital, 199 Jiefang South Road, Xuzhou 221009, Jiangsu Province, China.
Mao G; Department of Pathology, Xinyi People's Hospital, 16 Renmin Road, Xinyi 221400, Jiangsu Province, China.
Zhao B; Department of Gastroenterology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221002, Jiangsu Province, China.
Wu J; Department of Gastroenterology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221002, Jiangsu Province, China.
Shi H; Central Laboratory, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221002, Jiangsu Province, China. Electronic address: .
Fei S; Department of Gastroenterology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221002, Jiangsu Province, China; Institute of Digestive Diseases, Xuzhou Medical University, 84 West Huaihai Road, Xuzhou 221002, Jiangsu Province, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 May 15; Vol. 273, pp. 119308. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Brain-Derived Neurotrophic Factor/*metabolism
Diabetes Mellitus, Experimental/*physiopathology
Diabetic Neuropathies/*complications
Hyperalgesia/*etiology
Neuralgia/*complications
TRPC Cation Channels/*metabolism
Animals ; Behavior, Animal ; Brain-Derived Neurotrophic Factor/administration & dosage ; Hyperalgesia/metabolism ; Hyperalgesia/pathology ; Male ; Rats ; Rats, Sprague-Dawley ; TRPC Cation Channels/genetics
Czasopismo naukowe
Tytuł :
Early differences in membrane properties at the neuromuscular junctions of ALS model mice: Effects of 25-hydroxycholesterol.
Autorzy :
Zakyrjanova GF; Laboratory of Biophysics of Synaptic Processes, Kazan Institute of Biochemistry and Biophysics, Federal Research Center 'Kazan Scientific Center of RAS', 2/31 Lobachevsky Street, box 30, Kazan 420111, Russia; Institute of Neuroscience, Kazan State Medial University, 49 Butlerova Street, Kazan, 420012, Russia.
Giniatullin AR; Department of Normal Physiology, Kazan State Medial University, 49 Butlerova Street, Kazan 420012, Russia.
Mukhutdinova KA; Institute of Neuroscience, Kazan State Medial University, 49 Butlerova Street, Kazan, 420012, Russia.
Kuznetsova EA; Laboratory of Biophysics of Synaptic Processes, Kazan Institute of Biochemistry and Biophysics, Federal Research Center 'Kazan Scientific Center of RAS', 2/31 Lobachevsky Street, box 30, Kazan 420111, Russia.
Petrov AM; Laboratory of Biophysics of Synaptic Processes, Kazan Institute of Biochemistry and Biophysics, Federal Research Center 'Kazan Scientific Center of RAS', 2/31 Lobachevsky Street, box 30, Kazan 420111, Russia; Institute of Neuroscience, Kazan State Medial University, 49 Butlerova Street, Kazan, 420012, Russia. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 May 15; Vol. 273, pp. 119300. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Amyotrophic Lateral Sclerosis/*drug therapy
Hydroxycholesterols/*pharmacology
Membrane Microdomains/*drug effects
Muscle, Skeletal/*drug effects
Superoxide Dismutase-1/*physiology
Acetylcholine/metabolism ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Ceramides/metabolism ; Cholesterol/metabolism ; Female ; Male ; Membrane Microdomains/metabolism ; Membrane Microdomains/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Neuromuscular Junction ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Characterization of a Mouse Model of Alzheimer's Disease Expressing Aβ4-42 and Human Mutant Tau.
Autorzy :
Zampar S; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, D-37075 Göttingen, Germany.
Wirths O; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, D-37075 Göttingen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 14; Vol. 22 (10). Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Mutation*
Alzheimer Disease/*complications
Amyloid beta-Peptides/*metabolism
Memory Disorders/*etiology
Motor Disorders/*etiology
tau Proteins/*genetics
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Animals ; Behavior, Animal ; Female ; Humans ; Male ; Memory Disorders/metabolism ; Memory Disorders/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Motor Disorders/metabolism ; Motor Disorders/pathology ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Platforms for Personalized Polytherapeutics Discovery in COVID-19.
Autorzy :
Hopkins C; InVivo Biosystems, Eugene, OR, United States. Electronic address: .
Onweni C; Mayo Clinic, Rochester, MN, United States.
Zambito V; Mayo Clinic, Rochester, MN, United States.
Fairweather D; Mayo Clinic, Jacksonville, FL, United States.
McCormick K; InVivo Biosystems, Eugene, OR, United States.
Ebihara H; Mayo Clinic, Rochester, MN, United States.
Caulfield T; Mayo Clinic, Jacksonville, FL, United States.
Zhang YS; Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States.
Freeman WD; Mayo Clinic, Jacksonville, FL, United States.
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 May 14; Vol. 433 (10), pp. 166945. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Disease Models, Animal*
COVID-19/*drug therapy
Drug Evaluation, Preclinical/*methods
Induced Pluripotent Stem Cells/*drug effects
Animals ; Animals, Genetically Modified ; COVID-19/economics ; COVID-19/genetics ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/genetics ; Humans ; Zebrafish/genetics
Czasopismo naukowe
Tytuł :
The Prominin-1-Derived Peptide Improves Cardiac Function Following Ischemia.
Autorzy :
Adini A; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Adini I; Department of Surgery, Harvard Medical School, The Center for Engineering in Medicine, Mass General Hospital, Shriners Hospitals for Children Boston, Boston, MA 02114, USA.
Grad E; Interventional Cardiology, Heart Institute, Hadassah Hebrew University Medical Center, Jerusalem 91200, Israel.
Tal Y; Allergy and Clinical Immunology Unit and Department of Medicine, Hadassah University Medical Center, Jerusalem 91200, Israel.
Danenberg HD; Interventional Cardiology, Heart Institute, Hadassah Hebrew University Medical Center, Jerusalem 91200, Israel.
Kang PM; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Matthews BD; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
D'Amato RJ; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA 02115, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 13; Vol. 22 (10). Date of Electronic Publication: 2021 May 13.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
AC133 Antigen/*metabolism
Ischemia/*complications
Myocardial Infarction/*prevention & control
Neovascularization, Physiologic/*drug effects
Peptide Fragments/*pharmacology
Vascular Endothelial Growth Factor A/*metabolism
Animals ; Female ; Ischemia/metabolism ; Ischemia/pathology ; Mice ; Mice, Inbred C57BL ; Myocardial Infarction/etiology ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Vascular Endothelial Growth Factor A/genetics ; Ventricular Function, Left/drug effects
Czasopismo naukowe
Tytuł :
Gut microbiota regulation and anti-inflammatory effect of β-carotene in dextran sulfate sodium-stimulated ulcerative colitis in rats.
Autorzy :
Zhu L; College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Song Y; College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Liu H; School of Food Science and Technology, Dalian Polytechnic University, Liaoning, China.
Wu M; College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Gong H; College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Lan H; College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Zheng X; College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
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Źródło :
Journal of food science [J Food Sci] 2021 May; Vol. 86 (5), pp. 2118-2130. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Anti-Inflammatory Agents/*pharmacology
Colitis, Ulcerative/*drug therapy
Dextran Sulfate/*toxicity
Gastrointestinal Microbiome/*drug effects
beta Carotene/*pharmacology
Animals ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/microbiology ; Cytokines/metabolism ; Male ; Provitamins/pharmacology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Androgen receptor activation alleviates airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma.
Autorzy :
Kalidhindi RSR; Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, North Dakota.
Ambhore NS; Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, North Dakota.
Balraj P; Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, North Dakota.
Schmidt T; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota.
Khan MN; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota.
Sathish V; Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, North Dakota.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2021 May 01; Vol. 320 (5), pp. L803-L818. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Airway Remodeling*
Disease Models, Animal*
Gene Expression Regulation*
Asthma/*complications
Inflammation/*prevention & control
Receptors, Androgen/*metabolism
Respiratory Hypersensitivity/*prevention & control
Animals ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Androgen/genetics ; Respiratory Hypersensitivity/etiology ; Respiratory Hypersensitivity/metabolism ; Respiratory Hypersensitivity/pathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
SARS-CoV-2 infection of Chinese hamsters (Cricetulus griseus) reproduces COVID-19 pneumonia in a well-established small animal model.
Autorzy :
Bertzbach LD; Institut für Virologie, Freie Universität Berlin, Berlin, Germany.
Vladimirova D; Institut für Virologie, Freie Universität Berlin, Berlin, Germany.
Dietert K; Institut für Tierpathologie, Freie Universität Berlin, Berlin, Germany.; Tiermedizinisches Zentrum für Resistenzforschung, Freie Universität Berlin, Berlin, Germany.
Abdelgawad A; Institut für Virologie, Freie Universität Berlin, Berlin, Germany.
Gruber AD; Institut für Tierpathologie, Freie Universität Berlin, Berlin, Germany.
Osterrieder N; Institut für Virologie, Freie Universität Berlin, Berlin, Germany.; Department of Infectious Disease and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong.
Trimpert J; Institut für Virologie, Freie Universität Berlin, Berlin, Germany.
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Źródło :
Transboundary and emerging diseases [Transbound Emerg Dis] 2021 May; Vol. 68 (3), pp. 1075-1079. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
SARS-CoV-2*
COVID-19/*veterinary
Animals ; COVID-19/pathology ; Cricetinae ; Cricetulus ; Disease Susceptibility/pathology ; Disease Susceptibility/veterinary ; Humans ; Lung/pathology ; Lung/virology ; Virus Replication
Czasopismo naukowe
Tytuł :
Establishment of an experimental rat model of tacrolimus-induced kidney injury accompanied by interstitial fibrosis.
Autorzy :
Fu R; Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan.
Tajima S; Department of Pharmacy, Kyushu University Hospital, Japan. Electronic address: .
Shigematsu T; Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan; Department of Pharmacy, Kyushu University Hospital, Japan.
Zhang M; Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan.
Tsuchimoto A; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Egashira N; Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan; Department of Pharmacy, Kyushu University Hospital, Japan.
Ieiri I; Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan; Department of Pharmacy, Kyushu University Hospital, Japan.
Masuda S; Department of Pharmacy, International University of Health and Welfare Narita Hospital, Japan; Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, International University of Health and Welfare, Japan.
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Źródło :
Toxicology letters [Toxicol Lett] 2021 May 01; Vol. 341, pp. 43-50. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Fibrosis/*chemically induced
Immunosuppressive Agents/*toxicity
Kidney Diseases/*chemically induced
Tacrolimus/*toxicity
Animals ; Biomarkers/metabolism ; Gene Expression Regulation/drug effects ; Male ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Intratracheal administration of mesenchymal stem cell-derived extracellular vesicles reduces lung injuries in a chronic rat model of bronchopulmonary dysplasia.
Autorzy :
Porzionato A; Section of Human Anatomy, Department of Neuroscience, University of Padova, Padua, Italy.
Zaramella P; Neonatal Intensive Care Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy.
Dedja A; Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padova, Padua, Italy.
Guidolin D; Section of Human Anatomy, Department of Neuroscience, University of Padova, Padua, Italy.
Bonadies L; Neonatal Intensive Care Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy.
Macchi V; Section of Human Anatomy, Department of Neuroscience, University of Padova, Padua, Italy.
Pozzobon M; Institute of Pediatric Research, Padua, Italy.; Stem Cell and Regenerative Medicine Laboratory, Department of Women's and Children's Health, University of Padova, Padua, Italy.
Jurga M; The Cell Factory BVBA (Esperite NV), Niel, Belgium.
Perilongo G; Institute of Pediatric Research, Padua, Italy.; Pediatric Clinic, Department of Women's and Children's Health, University of Padova, Padua, Italy.
De Caro R; Section of Human Anatomy, Department of Neuroscience, University of Padova, Padua, Italy.
Baraldi E; Neonatal Intensive Care Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy.; Institute of Pediatric Research, Padua, Italy.
Muraca M; Institute of Pediatric Research, Padua, Italy.; Stem Cell and Regenerative Medicine Laboratory, Department of Women's and Children's Health, University of Padova, Padua, Italy.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2021 May 01; Vol. 320 (5), pp. L688-L704. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Bronchopulmonary Dysplasia/*complications
Extracellular Vesicles/*physiology
Lung Injury/*therapy
Mesenchymal Stem Cell Transplantation/*methods
Mesenchymal Stem Cells/*cytology
Administration, Inhalation ; Animals ; Animals, Newborn ; Female ; Hyperoxia/physiopathology ; Lung Injury/etiology ; Lung Injury/pathology ; Male ; Pulmonary Alveoli/cytology ; Pulmonary Alveoli/metabolism ; Pulmonary Artery/cytology ; Pulmonary Artery/metabolism ; Rats ; Rats, Sprague-Dawley ; Trachea
Czasopismo naukowe
Tytuł :
A novel pseudovirus-based mouse model of SARS-CoV-2 infection to test COVID-19 interventions.
Autorzy :
Tseng SH; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Lam B; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Graduate Program in Immunology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Kung YJ; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Lin J; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Liu L; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Tsai YC; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Ferrall L; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Roden RBS; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Wu TC; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Molecular Microbiology and Immunology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Hung CF; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA. .; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA. .; Johns Hopkins University School of Medicine, 1550 Orleans Street, CRBII 307, Baltimore, MD, 21287, USA. .
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Źródło :
Journal of biomedical science [J Biomed Sci] 2021 Apr 30; Vol. 28 (1), pp. 34. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*/prevention & control
COVID-19*/transmission
COVID-19*/virology
Disease Models, Animal*
Angiotensin-Converting Enzyme 2/*administration & dosage
SARS-CoV-2/*physiology
Spike Glycoprotein, Coronavirus/*physiology
Administration, Intranasal ; Animals ; Female ; Humans ; Lentivirus/physiology ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł :
The Kinetics of Lymphatic Dysfunction and Leukocyte Expansion in the Draining Lymph Node during LTB 4 Antagonism in a Mouse Model of Lymphedema.
Autorzy :
Cribb MT; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Sestito LF; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Rockson SG; Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.
Nicolls MR; Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.
Thomas SN; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Dixon JB; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 24; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Leucine/*analogs & derivatives
Leukocytes/*immunology
Leukotriene B4/*antagonists & inhibitors
Lymph Nodes/*immunology
Lymphatic Vessels/*immunology
Lymphedema/*immunology
Animals ; Female ; Kinetics ; Leucine/pharmacology ; Leukocytes/drug effects ; Leukocytes/metabolism ; Leukocytes/pathology ; Lymph Nodes/drug effects ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Lymphatic Vessels/drug effects ; Lymphatic Vessels/metabolism ; Lymphatic Vessels/pathology ; Lymphedema/drug therapy ; Lymphedema/metabolism ; Lymphedema/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Protease Inhibitors/pharmacology
Czasopismo naukowe

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