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Tytuł :
A time-resolved proteomic and prognostic map of COVID-19.
Autorzy :
Demichev V; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK; The University of Cambridge, Department of Biochemistry and Cambridge Centre for Proteomics, Cambridge CB21GA, UK.
Tober-Lau P; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Lemke O; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
Nazarenko T; University College London, Department of Mathematics, London WC1E 6BT, UK; University College London, Department of Women's Cancer, EGA Institute for Women'S Health, London WC1E 6BT, UK.
Thibeault C; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Whitwell H; National Phenome Centre and Imperial Clinical Phenotyping Centre, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW72AZ, UK; Lobachevsky University, Department of Applied Mathematics, Nizhny Novgorod 603105, Russia; Imperial College London, Section of Bioanalytical Chemistry, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, London SW7 2AZ, UK.
Röhl A; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
Freiwald A; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
Szyrwiel L; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
Ludwig D; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
Correia-Melo C; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
Aulakh SK; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
Helbig ET; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Stubbemann P; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Lippert LJ; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Grüning NM; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
Blyuss O; Lobachevsky University, Department of Applied Mathematics, Nizhny Novgorod 603105, Russia; University of Hertfordshire, School of Physics, Astronomy and Mathematics, Hatfield AL10 9AB, UK; Sechenov First Moscow State Medical University, Department of Paediatrics and Paediatric Infectious Diseases, Moscow 119435, Russia.
Vernardis S; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
White M; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
Messner CB; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
Joannidis M; Medical University Innsbruck, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, 6020 Innsbruck, Austria.
Sonnweber T; Medical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Klein SJ; Medical University Innsbruck, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, 6020 Innsbruck, Austria.
Pizzini A; Medical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Wohlfarter Y; Medical University of Innsbruck, Institute of Human Genetics, 6020 Innsbruck, Austria.
Sahanic S; Medical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Hilbe R; Medical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Schaefer B; Medical University of Innsbruck, Christian Doppler Laboratory for Iron and Phosphate Biology, Department of Internal Medicine I, 6020 Innsbruck, Austria.
Wagner S; Medical University of Innsbruck, Christian Doppler Laboratory for Iron and Phosphate Biology, Department of Internal Medicine I, 6020 Innsbruck, Austria.
Mittermaier M; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany.
Machleidt F; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Garcia C; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Ruwwe-Glösenkamp C; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Lingscheid T; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Bosquillon de Jarcy L; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Stegemann MS; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Pfeiffer M; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Jürgens L; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Denker S; Charité Universitätsmedizin Berlin, Medical Department of Hematology, Oncology & Tumor Immunology, Virchow Campus & Molekulares Krebsforschungszentrum, 13353 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany.
Zickler D; Charité Universitätsmedizin Berlin, Department of Nephrology and Internal Intensive Care Medicine, 10117 Berlin, Germany.
Enghard P; Charité Universitätsmedizin Berlin, Department of Nephrology and Internal Intensive Care Medicine, 10117 Berlin, Germany.
Zelezniak A; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK; Chalmers Tekniska Högskola, Department of Biology and Biological Engineering, SE-412 96 Gothenburg, Sweden.
Campbell A; University of Edinburgh, Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK; University of Edinburgh, Usher Institute, Edinburgh EH16 4UX, UK.
Hayward C; University of Edinburgh, MRC Human Genetics Unit, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK.
Porteous DJ; University of Edinburgh, Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK; University of Edinburgh, Usher Institute, Edinburgh EH16 4UX, UK.
Marioni RE; University of Edinburgh, Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK.
Uhrig A; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Müller-Redetzky H; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Zoller H; Medical University of Innsbruck, Christian Doppler Laboratory for Iron and Phosphate Biology, Department of Internal Medicine I, 6020 Innsbruck, Austria.
Löffler-Ragg J; Medical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Keller MA; Medical University of Innsbruck, Institute of Human Genetics, 6020 Innsbruck, Austria.
Tancevski I; Medical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Timms JF; University College London, Department of Women's Cancer, EGA Institute for Women'S Health, London WC1E 6BT, UK.
Zaikin A; University College London, Department of Mathematics, London WC1E 6BT, UK; University College London, Department of Women's Cancer, EGA Institute for Women'S Health, London WC1E 6BT, UK; Lobachevsky University, Laboratory of Systems Medicine of Healthy Ageing, Nizhny Novgorod 603105, Russia.
Hippenstiel S; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; German Centre for Lung Research, 35392 Gießen, Germany.
Ramharter M; Bernhard Nocht Institute for Tropical Medicine, Department of Tropical Medicine, and University Medical Center Hamburg-Eppendorf, Department of Medicine, 20359 Hamburg, Germany.
Witzenrath M; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; German Centre for Lung Research, 35392 Gießen, Germany.
Suttorp N; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; German Centre for Lung Research, 35392 Gießen, Germany.
Lilley K; The University of Cambridge, Department of Biochemistry and Cambridge Centre for Proteomics, Cambridge CB21GA, UK.
Mülleder M; Charité - Universitätsmedizin Berlin, Core Facility - High-Throughput Mass Spectrometry, 10117 Berlin, Germany.
Sander LE; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; German Centre for Lung Research, 35392 Gießen, Germany.
Ralser M; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK. Electronic address: .
Kurth F; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; Bernhard Nocht Institute for Tropical Medicine, Department of Tropical Medicine, and University Medical Center Hamburg-Eppendorf, Department of Medicine, 20359 Hamburg, Germany.
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Corporate Authors :
PA-COVID-19 Study group
Źródło :
Cell systems [Cell Syst] 2021 Aug 18; Vol. 12 (8), pp. 780-794.e7. Date of Electronic Publication: 2021 Jun 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Biomarkers/*analysis
COVID-19/*pathology
Proteome/*physiology
Age Factors ; Blood Cell Count ; Blood Gas Analysis ; Enzyme Activation ; Humans ; Inflammation/pathology ; Machine Learning ; Prognosis ; Proteomics ; SARS-CoV-2/immunology
Czasopismo naukowe
Tytuł :
Disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic in March-October 2020: An exploratory analysis.
Autorzy :
Modrák M; Bioinformatics Core Facility, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.
Bürkner PC; Cluster of Excellence SimTech, University of Stuttgart, Stuttgart, Deutschland, Germany.
Sieger T; Dept. of Cybernetics, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
Slisz T; Department of Respiratory Medicine, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.; Thomayer University Hospital, Prague, Czech Republic.
Vašáková M; Department of Respiratory Medicine, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.; Thomayer University Hospital, Prague, Czech Republic.
Mesežnikov G; Motol University Hospital, Prague, Czech Republic.
Casas-Mendez LF; Motol University Hospital, Prague, Czech Republic.
Vajter J; Motol University Hospital, Prague, Czech Republic.
Táborský J; AGEL Hospital Nový Jičín, Nový Jičín, Czech Republic.
Kubricht V; Kralovské Vinohrady University Hospital, Prague, Czech Republic.
Suk D; General University Hospital in Prague, Prague, Czech Republic.
Horejsek J; General University Hospital in Prague, Prague, Czech Republic.
Jedlička M; Military Hospital Olomouc, Olomouc, Czech Republic.
Mifková A; Military Hospital Olomouc, Olomouc, Czech Republic.
Jaroš A; Na Homolce Hospital, Prague, Czech Republic.
Kubiska M; Department of Infectious Diseases and Travel Medicine, Faculty of Medicine in Pilsen, Charles University, University Hospital in Pilsen, Pilsen, Czech Republic.
Váchalová J; Department of Infectious Diseases and Travel Medicine, Faculty of Medicine in Pilsen, Charles University, University Hospital in Pilsen, Pilsen, Czech Republic.
Šín R; Department of Infectious Diseases and Travel Medicine, Faculty of Medicine in Pilsen, Charles University, University Hospital in Pilsen, Pilsen, Czech Republic.
Veverková M; Hořovice Hospital, Hořovice, Czech Republic.
Pospíšil Z; Třebíč Hospital, Třebíč, Czech Republic.
Vohryzková J; 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Pokrievková R; 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Hrušák K; 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Christozova K; 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Leos-Barajas V; Department of Statistical Sciences, University of Toronto, Toronto, Canada.
Fišer K; Department of Bioinformatics, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Hyánek T; Na Homolce Hospital, Prague, Czech Republic.
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Źródło :
PloS one [PLoS One] 2021 Oct 06; Vol. 16 (10), pp. e0245103. Date of Electronic Publication: 2021 Oct 06 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Hospitalization*
COVID-19/*epidemiology
Adult ; Aged ; COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/therapy ; Czech Republic/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Models, Statistical
Czasopismo naukowe
Tytuł :
Myasthenia gravis exacerbation in association with antibody overshoot following plasmapheresis.
Autorzy :
Ching J; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Richards D; Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Lewis RA; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Li Y; Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
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Źródło :
Muscle & nerve [Muscle Nerve] 2021 Oct; Vol. 64 (4), pp. 483-487. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Disease Progression*
Autoantibodies/*blood
Myasthenia Gravis/*blood
Myasthenia Gravis/*therapy
Plasmapheresis/*trends
Adult ; Aged ; Anti-Inflammatory Agents/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Myasthenia Gravis/diagnosis ; Plasmapheresis/adverse effects ; Receptors, Cholinergic/blood ; Retrospective Studies
Czasopismo naukowe
Tytuł :
COVID-19 infection, progression, and vaccination: Focus on obesity and related metabolic disturbances.
Autorzy :
Westheim AJF; Department of Precision Medicine, GROW-Research School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands.
Bitorina AV; Department of Molecular Genetics, NUTRIM-School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
Theys J; Department of Precision Medicine, GROW-Research School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands.
Shiri-Sverdlov R; Department of Molecular Genetics, NUTRIM-School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
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Źródło :
Obesity reviews : an official journal of the International Association for the Study of Obesity [Obes Rev] 2021 Oct; Vol. 22 (10), pp. e13313. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
COVID-19*/complications
COVID-19*/immunology
COVID-19*/physiopathology
COVID-19*/prevention & control
COVID-19 Vaccines*
Disease Progression*
Obesity/*complications
Obesity/*metabolism
Humans ; SARS-CoV-2 ; Vaccination
Czasopismo naukowe
Tytuł :
Predicting COVID-19 progression from diagnosis to recovery or death linking primary care and hospital records in Castilla y León (Spain).
Autorzy :
Álvarez-Esteban PC; Department of Statistics and Operations Research, Universidad de Valladolid, Valladolid, Spain.
Del Barrio E; Department of Statistics and Operations Research, Universidad de Valladolid, Valladolid, Spain.
Rueda OM; MRC-Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom.
Rueda C; Department of Statistics and Operations Research, Universidad de Valladolid, Valladolid, Spain.
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Źródło :
PloS one [PLoS One] 2021 Sep 20; Vol. 16 (9), pp. e0257613. Date of Electronic Publication: 2021 Sep 20 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Disease Progression*
Hospital Records*
Hospitals*
Primary Health Care*
COVID-19/*diagnosis
COVID-19/*mortality
Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/drug therapy ; Calibration ; Child ; Child, Preschool ; Comorbidity ; Confidence Intervals ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Probability ; Proportional Hazards Models ; Reproducibility of Results ; Spain/epidemiology ; Young Adult
Czasopismo naukowe
Tytuł :
Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial.
Autorzy :
Schwarzschild MA; Mass General Institute for Neurodegenerative Disease, Boston, Massachusetts.; Massachusetts General Hospital, Boston.
Ascherio A; Harvard School of Public Health, Boston, Massachusetts.
Casaceli C; University of Rochester, Rochester, New York.
Curhan GC; Brigham and Women's Hospital, Boston, Massachusetts.
Fitzgerald R; Parkinson's Foundation Research Advocates, Parkinson's Foundation, New York, New York.
Kamp C; University of Rochester, Rochester, New York.
Lungu C; Division of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
Macklin EA; Massachusetts General Hospital, Boston.; Harvard Medical School, Boston, Massachusetts.
Marek K; Institute for Neurodegenerative Disorders, New Haven, Connecticut.
Mozaffarian D; Tufts School of Medicine and Division of Cardiology, Tufts Medical Center, Boston, Massachusetts.; Friedman School of Nutrition Science and Policy, Boston, Massachusetts.
Oakes D; University of Rochester, Rochester, New York.
Rudolph A; University of Rochester, Rochester, New York.
Shoulson I; Department of Neurology, University of Rochester Medical Center, Rochester, New York.
Videnovic A; Massachusetts General Hospital, Boston.
Scott B; Duke University, Durham, North Carolina.
Gauger L; Duke Medical Center, Durham, North Carolina.
Aldred J; Inland Northwest Research, Spokane, Washington.; Selkirk Neurology, Spokane, Washington.
Bixby M; Inland Northwest Research, Spokane, Washington.
Ciccarello J; Inland Northwest Research, Spokane, Washington.
Gunzler SA; University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Henchcliffe C; University of California, Irvine.; Weill Cornell Medical College, New York, New York.
Brodsky M; Oregon Health & Science University, Portland.
Keith K; Oregon Health & Science University, Portland.
Hauser RA; University of South Florida, Tampa.
Goetz C; Rush University Medical Center, Chicago, Illinois.
LeDoux MS; Veracity Neuroscience LLC, Memphis, Tennessee.
Hinson V; Medical University of South Carolina, Charleston.
Kumar R; Rocky Mountain Movement Disorders Center, Englewood, Colorado.
Espay AJ; University of Cincinnati, Cincinnati, Ohio.
Jimenez-Shahed J; Icahn School of Medicine at Mount Sinai, New York, New York.
Hunter C; Baylor College of Medicine, Houston, Texas.
Christine C; University of California, San Francisco.
Daley A; University of California, San Francisco.
Leehey M; University of Colorado, Denver.
de Marcaida JA; Ayer Neuroscience Institute, Hartford HealthCare, Hartford, Connecticut.
Friedman JH; Butler Hospital, Providence, Rhode Island.
Hung A; Massachusetts General Hospital, Boston.
Bwala G; Massachusetts General Hospital, Boston.
Litvan I; University of California, San Diego.
Simon DK; Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Simuni T; Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Poon C; Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Schiess MC; The University of Texas Health Science Center, Houston McGovern Medical School, Houston.
Chou K; University of Michigan, Ann Arbor.
Park A; The Ohio State University Wexner Medical Center, Columbus.
Bhatti D; University of Nebraska Medical Center, Omaha.
Peterson C; University of Nebraska Medical Center, Omaha.
Criswell SR; Washington University School of Medicine in St Louis, St Louis, Missouri.
Rosenthal L; Johns Hopkins School of Medicine, Baltimore, Maryland.
Durphy J; Albany Medical College, Albany, New York.
Shill HA; Banner Sun Health Research Institute, Sun City, Arizona.; University of Arizona School of Medicine-Phoenix.
Mehta SH; Mayo Clinic Arizona, Scottsdale.
Ahmed A; Cleveland Clinic, Cleveland, Ohio.
Deik AF; University of Pennsylvania, Philadelphia.
Fang JY; Vanderbilt University Medical Center, Nashville, Tennessee.
Stover N; The University of Alabama at Birmingham.
Zhang L; UC Davis, Davis, California.
Dewey RB Jr; University of Texas Southwestern Medical Center, Dallas.
Gerald A; University of Texas Southwestern Medical Center, Dallas.
Boyd JT; University of Vermont, Burlington.
Houston E; University of Vermont Medical Center, Burlington.
Suski V; University of Pittsburgh, Pittsburgh, Pennsylvania.
Mosovsky S; University of Pittsburgh, Pittsburgh, Pennsylvania.
Cloud L; VCU Parkinson's & Movement Disorders Center, Richmond, Virginia.
Shah BB; University of Virginia, Charlottesville.
Saint-Hilaire M; Boston University School of Medicine, Boston, Massachusetts.
James R; Boston Medical Center, Boston, Massachusetts.
Zauber SE; Indiana University, Bloomington.
Reich S; University of Maryland School of Medicine, Baltimore.
Shprecher D; Banner Sun Health Research Institute, Sun City, Arizona.; University of Arizona School of Medicine-Phoenix.
Pahwa R; University of Kansas Medical Center, Kansas City.
Langhammer A; University of Kansas Medical Center, Kansas City.
LaFaver K; Northwestern University Feinberg School of Medicine, Chicago, Illinois.
LeWitt PA; Henry Ford Hospital-West Bloomfield, West Bloomfield Township, Michigan.
Kaminski P; Henry Ford Hospital-West Bloomfield, West Bloomfield Township, Michigan.
Goudreau J; Michigan State University, East Lansing.
Russell D; Michigan State University, East Lansing.
Houghton DJ; Ochsner Medical Center, Jefferson, Louisiana.
Laroche A; Ochsner Health System, Jefferson, Louisiana.
Thomas K; Sentara Neurology Specialists, Norfolk, Virginia.
McGraw M; Center for Movement Disorders and Neurodegenerative Disease, Northwestern Medicine/Central DuPage Hospital, Winfield, Illinois.
Mari Z; Cleveland Clinic-Las Vegas, Las Vegas, Nevada.
Serrano C; University of Puerto Rico, San Juan.
Blindauer K; Medical College of Wisconsin, Milwaukee.
Rabin M; Atlantic Neuroscience Institute, Summit, New Jersey.
Kurlan R; Atlantic Neuroscience Institute, Summit, New Jersey.
Morgan JC; Augusta University, Augusta, Georgia.
Soileau M; Texas Movement Disorder Specialists, Georgetown.; Scott & White Healthcare/Texas A&M University, Temple.
Ainslie M; Baylor Scott & White Health, Temple, Texas.
Bodis-Wollner I; State University of New York Downstate Medical Center, Brooklyn.
Schneider RB; University of Rochester, Rochester, New York.
Waters C; Columbia University, New York, New York.
Ratel AS; Columbia University, New York, New York.
Beck CA; University of Rochester Medical Center, Rochester, New York.
Bolger P; University of Rochester, Rochester, New York.
Callahan KF; Massachusetts General Hospital, Boston.
Crotty GF; Massachusetts General Hospital, Boston.
Klements D; Massachusetts General Hospital, Boston.
Kostrzebski M; University of Rochester, Rochester, New York.
McMahon GM; Brigham and Women's Hospital, Boston, Massachusetts.
Pothier L; Massachusetts General Hospital, Boston.
Waikar SS; Boston University School of Medicine, Boston, Massachusetts.; Boston Medical Center, Boston, Massachusetts.
Lang A; University of Toronto, Toronto, Ontario, Canada.; Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, Ontario, Canada.
Mestre T; University of Ottawa, Ottawa, Ontario, Canada.
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Corporate Authors :
Parkinson Study Group SURE-PD3 Investigators
Źródło :
JAMA [JAMA] 2021 Sep 14; Vol. 326 (10), pp. 926-939.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Inosine/*therapeutic use
Parkinson Disease/*drug therapy
Uric Acid/*blood
Aged ; Biomarkers/blood ; Dopamine Plasma Membrane Transport Proteins/deficiency ; Double-Blind Method ; Female ; Humans ; Inosine/adverse effects ; Kidney Calculi/chemically induced ; Male ; Middle Aged ; Parkinson Disease/blood ; Parkinson Disease/physiopathology ; Severity of Illness Index ; Treatment Failure
Czasopismo naukowe
Tytuł :
Progression of Clinical Features in Lewy Body Dementia Can Be Detected Over 6 Months.
Autorzy :
Matar E; From the Department of Psychiatry (E.M., S.R.W., A.S., J.T.O.) and MRC Biostatistics Unit (S.R.W.), University of Cambridge, UK; Forefront Parkinson's Disease Research Clinic (E.M., G.M.H., S.J.G.L.) and Brain and Mind Centre (E.M., G.M.H., S.J.G.L.), Faculty of Medicine and Health, University of Sydney, Australia; Newcastle Translational and Clinical Research Institute (J.-P.T., A.T., I.G.M.), Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne; and Centre for Public Health (J.P.M.K.), Queen's University Belfast, UK. .
White SR; From the Department of Psychiatry (E.M., S.R.W., A.S., J.T.O.) and MRC Biostatistics Unit (S.R.W.), University of Cambridge, UK; Forefront Parkinson's Disease Research Clinic (E.M., G.M.H., S.J.G.L.) and Brain and Mind Centre (E.M., G.M.H., S.J.G.L.), Faculty of Medicine and Health, University of Sydney, Australia; Newcastle Translational and Clinical Research Institute (J.-P.T., A.T., I.G.M.), Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne; and Centre for Public Health (J.P.M.K.), Queen's University Belfast, UK.
Taylor JP; From the Department of Psychiatry (E.M., S.R.W., A.S., J.T.O.) and MRC Biostatistics Unit (S.R.W.), University of Cambridge, UK; Forefront Parkinson's Disease Research Clinic (E.M., G.M.H., S.J.G.L.) and Brain and Mind Centre (E.M., G.M.H., S.J.G.L.), Faculty of Medicine and Health, University of Sydney, Australia; Newcastle Translational and Clinical Research Institute (J.-P.T., A.T., I.G.M.), Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne; and Centre for Public Health (J.P.M.K.), Queen's University Belfast, UK.
Thomas A; From the Department of Psychiatry (E.M., S.R.W., A.S., J.T.O.) and MRC Biostatistics Unit (S.R.W.), University of Cambridge, UK; Forefront Parkinson's Disease Research Clinic (E.M., G.M.H., S.J.G.L.) and Brain and Mind Centre (E.M., G.M.H., S.J.G.L.), Faculty of Medicine and Health, University of Sydney, Australia; Newcastle Translational and Clinical Research Institute (J.-P.T., A.T., I.G.M.), Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne; and Centre for Public Health (J.P.M.K.), Queen's University Belfast, UK.
McKeith IG; From the Department of Psychiatry (E.M., S.R.W., A.S., J.T.O.) and MRC Biostatistics Unit (S.R.W.), University of Cambridge, UK; Forefront Parkinson's Disease Research Clinic (E.M., G.M.H., S.J.G.L.) and Brain and Mind Centre (E.M., G.M.H., S.J.G.L.), Faculty of Medicine and Health, University of Sydney, Australia; Newcastle Translational and Clinical Research Institute (J.-P.T., A.T., I.G.M.), Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne; and Centre for Public Health (J.P.M.K.), Queen's University Belfast, UK.
Kane JPM; From the Department of Psychiatry (E.M., S.R.W., A.S., J.T.O.) and MRC Biostatistics Unit (S.R.W.), University of Cambridge, UK; Forefront Parkinson's Disease Research Clinic (E.M., G.M.H., S.J.G.L.) and Brain and Mind Centre (E.M., G.M.H., S.J.G.L.), Faculty of Medicine and Health, University of Sydney, Australia; Newcastle Translational and Clinical Research Institute (J.-P.T., A.T., I.G.M.), Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne; and Centre for Public Health (J.P.M.K.), Queen's University Belfast, UK.
Surendranathan A; From the Department of Psychiatry (E.M., S.R.W., A.S., J.T.O.) and MRC Biostatistics Unit (S.R.W.), University of Cambridge, UK; Forefront Parkinson's Disease Research Clinic (E.M., G.M.H., S.J.G.L.) and Brain and Mind Centre (E.M., G.M.H., S.J.G.L.), Faculty of Medicine and Health, University of Sydney, Australia; Newcastle Translational and Clinical Research Institute (J.-P.T., A.T., I.G.M.), Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne; and Centre for Public Health (J.P.M.K.), Queen's University Belfast, UK.
Halliday GM; From the Department of Psychiatry (E.M., S.R.W., A.S., J.T.O.) and MRC Biostatistics Unit (S.R.W.), University of Cambridge, UK; Forefront Parkinson's Disease Research Clinic (E.M., G.M.H., S.J.G.L.) and Brain and Mind Centre (E.M., G.M.H., S.J.G.L.), Faculty of Medicine and Health, University of Sydney, Australia; Newcastle Translational and Clinical Research Institute (J.-P.T., A.T., I.G.M.), Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne; and Centre for Public Health (J.P.M.K.), Queen's University Belfast, UK.
Lewis SJG; From the Department of Psychiatry (E.M., S.R.W., A.S., J.T.O.) and MRC Biostatistics Unit (S.R.W.), University of Cambridge, UK; Forefront Parkinson's Disease Research Clinic (E.M., G.M.H., S.J.G.L.) and Brain and Mind Centre (E.M., G.M.H., S.J.G.L.), Faculty of Medicine and Health, University of Sydney, Australia; Newcastle Translational and Clinical Research Institute (J.-P.T., A.T., I.G.M.), Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne; and Centre for Public Health (J.P.M.K.), Queen's University Belfast, UK.
O'Brien JT; From the Department of Psychiatry (E.M., S.R.W., A.S., J.T.O.) and MRC Biostatistics Unit (S.R.W.), University of Cambridge, UK; Forefront Parkinson's Disease Research Clinic (E.M., G.M.H., S.J.G.L.) and Brain and Mind Centre (E.M., G.M.H., S.J.G.L.), Faculty of Medicine and Health, University of Sydney, Australia; Newcastle Translational and Clinical Research Institute (J.-P.T., A.T., I.G.M.), Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne; and Centre for Public Health (J.P.M.K.), Queen's University Belfast, UK.
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Źródło :
Neurology [Neurology] 2021 Sep 07; Vol. 97 (10), pp. e1031-e1040. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Lewy Body Disease*/physiopathology
Aged ; Aged, 80 and over ; Cognitive Dysfunction/physiopathology ; Female ; Humans ; Longitudinal Studies ; Male ; Parkinson Disease/physiopathology
Czasopismo naukowe
Tytuł :
COVID-19-accelerated disease progression in two patients with amyotrophic lateral sclerosis.
Autorzy :
Li X; Duke ALS Clinic, Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA.
Bedlack R; Duke ALS Clinic, Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA.
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Źródło :
Muscle & nerve [Muscle Nerve] 2021 Sep; Vol. 64 (3), pp. E13-E15. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Disease Progression*
Amyotrophic Lateral Sclerosis/*complications
Amyotrophic Lateral Sclerosis/*diagnosis
COVID-19/*complications
COVID-19/*diagnosis
Aged ; Fatal Outcome ; Humans ; Male
Raport
Tytuł :
Sustained decrease in pediatric asthma emergency visits during the first year of the COVID-19 pandemic.
Autorzy :
Arsenault S; From the Division of Allergy and Immunology, Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, and.
Hoofman J; From the Division of Allergy and Immunology, Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, and.
Poowuttikul P; Division of Allergy and Immunology, Department of Pediatrics, Central Michigan University School of Medicine, Mount Pleasant, Michigan.
Secord E; From the Division of Allergy and Immunology, Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, and.
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Źródło :
Allergy and asthma proceedings [Allergy Asthma Proc] 2021 Sep 01; Vol. 42 (5), pp. 400-402.
Typ publikacji :
Journal Article
MeSH Terms :
Asthma*/etiology
Asthma*/physiopathology
Asthma*/therapy
Disease Progression*
COVID-19/*prevention & control
Emergency Service, Hospital/*trends
Facilities and Services Utilization/*trends
Acute Disease ; Adolescent ; Child ; Child, Preschool ; Environmental Exposure/prevention & control ; Environmental Exposure/statistics & numerical data ; Female ; Humans ; Male ; Michigan ; Physical Distancing ; Schools ; Urban Health
Czasopismo naukowe
Tytuł :
Impact of COVID-19 national lockdown on asthma exacerbations: interrupted time-series analysis of English primary care data.
Autorzy :
Shah SA; Asthma UK Centre for Applied Research, Centre for Medical Informatics, Usher Institute, The University of Edinburgh, Edinburgh, UK .
Quint JK; National Heart & Lung Institute, Imperial College London, London, UK.
Nwaru BI; Asthma UK Centre for Applied Research, Centre for Medical Informatics, Usher Institute, The University of Edinburgh, Edinburgh, UK.; Krefting Research Centre, The University of Edinburgh, Gothenburg, Sweden.
Sheikh A; Asthma UK Centre for Applied Research, Centre for Medical Informatics, Usher Institute, The University of Edinburgh, Edinburgh, UK.
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Źródło :
Thorax [Thorax] 2021 Sep; Vol. 76 (9), pp. 860-866. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Symptom Flare Up*
Asthma/*epidemiology
COVID-19/*prevention & control
Primary Health Care/*statistics & numerical data
Administration, Oral ; Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Asthma/drug therapy ; Emergency Service, Hospital/statistics & numerical data ; England/epidemiology ; Female ; Humans ; Interrupted Time Series Analysis ; Male ; Middle Aged ; Patient Admission/statistics & numerical data ; SARS-CoV-2 ; Young Adult
Czasopismo naukowe
Tytuł :
Overexpression of dopamine receptor D2 promotes colorectal cancer progression by activating the β-catenin/ZEB1 axis.
Autorzy :
Lee H; Laboratory of Radiation Exposure & Therapeutics, National Radiation Emergency Medical Center, Seoul, Korea.
Shim S; Laboratory of Radiation Exposure & Therapeutics, National Radiation Emergency Medical Center, Seoul, Korea.
Kong JS; Laboratory of Radiation Exposure & Therapeutics, National Radiation Emergency Medical Center, Seoul, Korea.; Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Science, Seoul, Korea.
Kim MJ; Laboratory of Radiation Exposure & Therapeutics, National Radiation Emergency Medical Center, Seoul, Korea.
Park S; Laboratory of Radiation Exposure & Therapeutics, National Radiation Emergency Medical Center, Seoul, Korea.; Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Science, Seoul, Korea.
Lee SS; Laboratory of Radiation Exposure & Therapeutics, National Radiation Emergency Medical Center, Seoul, Korea.; Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Science, Seoul, Korea.
Kim A; Laboratory of Radiation Exposure & Therapeutics, National Radiation Emergency Medical Center, Seoul, Korea.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3732-3743. Date of Electronic Publication: 2021 Jul 04.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Progression*
Colorectal Neoplasms/*metabolism
Colorectal Neoplasms/*mortality
Receptors, Dopamine D2/*metabolism
Zinc Finger E-box-Binding Homeobox 1/*metabolism
beta Catenin/*metabolism
Aged ; Animals ; Cell Movement/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Dopamine Antagonists/pharmacology ; Female ; HCT116 Cells ; HT29 Cells ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Pimozide/pharmacology ; RNA Interference ; Receptors, Dopamine D2/genetics ; Signal Transduction ; Survival Rate ; Transfection ; Tumor Burden/drug effects ; Tumor Burden/genetics ; Up-Regulation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Evidence of lung perfusion defects and ongoing inflammation in an adolescent with post-acute sequelae of SARS-CoV-2 infection.
Autorzy :
Buonsenso D; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Global Health Research Institute, Istituto di Igiene, Università Cattolica del Sacro Cuore, Rome, Italy; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: .
Di Giuda D; Nuclear Medicine Unit, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Istituto di Medicina Nucleare, Università Cattolica del Sacro Cuore, Rome, Italy.
Sigfrid L; International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Global Support Centre, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Pizzuto DA; Nuclear Medicine Unit, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Di Sante G; Dipartimento di Medicina e Chirurgia Traslazionale, Sezione di Patologia Generale, Università Cattolica del Sacro Cuore, Rome, Italy.
De Rose C; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.
Lazzareschi I; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.
Sali M; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy.
Baldi F; Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.
Chieffo DPR; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Clinical Psychology Unit, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.
Munblit D; Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; Inflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.
Valentini P; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Global Health Research Institute, Istituto di Igiene, Università Cattolica del Sacro Cuore, Rome, Italy.
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Źródło :
The Lancet. Child & adolescent health [Lancet Child Adolesc Health] 2021 Sep; Vol. 5 (9), pp. 677-680. Date of Electronic Publication: 2021 Jul 31.
Typ publikacji :
Case Reports; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Inflammation*
Perfusion*
COVID-19/*complications
Lung/*physiopathology
SARS-CoV-2/*physiology
Adolescent ; COVID-19/immunology ; Female ; Humans ; Longitudinal Studies
SCR Disease Name :
post-acute COVID-19 syndrome
Raport
Tytuł :
Sex differences in the Buffalo Concussion Treadmill Test in adolescents with acute sport-related concussion.
Autorzy :
Chizuk HM; Department of Rehabilitation Sciences, School of Public Health and Health Professions, State University of New York at Buffalo, United States of America; UBMD Orthopedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, United States of America. Electronic address: .
Willer BS; Department of Rehabilitation Sciences, School of Public Health and Health Professions, State University of New York at Buffalo, United States of America; Department of Psychiatry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, United States of America.
Horn EC; UBMD Orthopedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, United States of America.
Haider MN; UBMD Orthopedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, United States of America.
Leddy JJ; Department of Rehabilitation Sciences, School of Public Health and Health Professions, State University of New York at Buffalo, United States of America; UBMD Orthopedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, United States of America.
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Źródło :
Journal of science and medicine in sport [J Sci Med Sport] 2021 Sep; Vol. 24 (9), pp. 876-880. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Progression*
Sex Factors*
Athletic Injuries/*physiopathology
Brain Concussion/*physiopathology
Exercise Tolerance/*physiology
Heart Rate/*physiology
Adolescent ; Exercise Test/methods ; Female ; Humans ; Male ; New York ; Prospective Studies ; Rest/physiology ; Time Factors ; Visual Analog Scale
Czasopismo naukowe
Tytuł :
Interrelationship between the 5-lipoxygenase pathway and microbial dysbiosis in the progression of Alzheimer's disease.
Autorzy :
Mathis SP; Department of Microbiology and Immunology, James Graham Brown Cancer Center and Center for Microbiomics, Inflammation and Pathogenicity, Louisville, KY 40202, United States of America; University of Louisville Health Sciences Center, Louisville, KY 40202, United States of America.
Bodduluri SR; Department of Microbiology and Immunology, James Graham Brown Cancer Center and Center for Microbiomics, Inflammation and Pathogenicity, Louisville, KY 40202, United States of America; University of Louisville Health Sciences Center, Louisville, KY 40202, United States of America.
Haribabu B; Department of Microbiology and Immunology, James Graham Brown Cancer Center and Center for Microbiomics, Inflammation and Pathogenicity, Louisville, KY 40202, United States of America; University of Louisville Health Sciences Center, Louisville, KY 40202, United States of America. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2021 Sep; Vol. 1866 (9), pp. 158982. Date of Electronic Publication: 2021 May 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Progression*
Alzheimer Disease/*enzymology
Alzheimer Disease/*microbiology
Arachidonate 5-Lipoxygenase/*metabolism
Dysbiosis/*complications
Alzheimer Disease/complications ; Animals ; Brain/metabolism ; Disease Models, Animal ; Gastrointestinal Microbiome ; Mice
Czasopismo naukowe
Tytuł :
Discovery of Parkinson's disease states and disease progression modelling: a longitudinal data study using machine learning.
Autorzy :
Severson KA; Center for Computational Health, IBM Research, Cambridge, MA, USA. Electronic address: .
Chahine LM; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Smolensky LA; Michael J Fox Foundation, New York, NY, USA.
Dhuliawala M; Center for Computational Health, IBM Research, Cambridge, MA, USA.
Frasier M; Michael J Fox Foundation, New York, NY, USA.
Ng K; Center for Computational Health, IBM Research, Cambridge, MA, USA.
Ghosh S; Center for Computational Health, IBM Research, Cambridge, MA, USA.
Hu J; Center for Computational Health, IBM Research, Yorktown Heights, NY, USA.
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Źródło :
The Lancet. Digital health [Lancet Digit Health] 2021 Sep; Vol. 3 (9), pp. e555-e564. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Machine Learning*
Models, Statistical*
Parkinson Disease/*diagnosis
Parkinson Disease/*pathology
Aged ; Biological Variation, Individual ; Biological Variation, Population ; Dopamine Agents/therapeutic use ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Parkinson Disease/drug therapy
Czasopismo naukowe
Tytuł :
The nonsmokers' and smokers' pathways in lung adenocarcinoma: Histological progression and molecular bases.
Autorzy :
Okudela K; Department of Pathology, Graduate School of Medicine, Yokohama City University, Yokohama, China.
Matsumura M; Department of Pathology, Graduate School of Medicine, Yokohama City University, Yokohama, China.
Arai H; Devision of General Thoracic Surgery, Kanagawa Cardiovascular and Respiratory Center Hospital, Yokohama, China.
Woo T; Devision of Thoracic Surgery, Yokohama City University Medical Center Hospital, Yokohama, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3411-3418. Date of Electronic Publication: 2021 Jul 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Disease Progression*
Non-Smokers*
Smokers*
Smoking*
Adenocarcinoma of Lung/*genetics
Adenocarcinoma of Lung/*metabolism
Lung Neoplasms/*genetics
Lung Neoplasms/*metabolism
Adenocarcinoma of Lung/pathology ; Adult ; Aged ; Aged, 80 and over ; ErbB Receptors/genetics ; Female ; Humans ; Lung/pathology ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Mutation ; Proto-Oncogene Proteins p21(ras)/genetics ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Association of consciousness impairment and mortality in people with COVID-19.
Autorzy :
Xiong W; Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.; Institute of Brain Science and Brain-inspired technology of West China Hospital, Sichuan University, Chengdu, China.
Lu L; Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.; Institute of Brain Science and Brain-inspired technology of West China Hospital, Sichuan University, Chengdu, China.
Zhang B; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Luo J; Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Li W; Department of Pulmonary & Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.
He L; Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.; Institute of Brain Science and Brain-inspired technology of West China Hospital, Sichuan University, Chengdu, China.
Sander JW; Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.; Institute of Brain Science and Brain-inspired technology of West China Hospital, Sichuan University, Chengdu, China.; UCL Queen Square Institute of Neurology, NIHR University College London Hospitals Biomedical Research Centre, London, UK.; Chalfont Centre for Epilepsy, Chalfont St Peter, UK.; Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands.
Mu J; Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.; Institute of Brain Science and Brain-inspired technology of West China Hospital, Sichuan University, Chengdu, China.
Zhu C; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Zhou D; Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.; Institute of Brain Science and Brain-inspired technology of West China Hospital, Sichuan University, Chengdu, China.
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Źródło :
Acta neurologica Scandinavica [Acta Neurol Scand] 2021 Sep; Vol. 144 (3), pp. 251-259. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Consciousness*
Disease Progression*
COVID-19/*mortality
COVID-19/*physiopathology
COVID-19/virology ; Female ; Glasgow Coma Scale ; Humans ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2/pathogenicity ; Time Factors
Czasopismo naukowe
Tytuł :
Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis: A Prospective Multicenter Study.
Autorzy :
Ta D; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada. .
Ishaque A; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Srivastava O; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Hanstock C; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Seres P; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Eurich DT; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Luk C; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Briemberg H; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Frayne R; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Genge AL; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Graham SJ; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Korngut L; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Zinman L; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada.
Kalra S; From the Neuroscience and Mental Health Institute (D.T., A.I., O.S., S.K.), Department of Biomedical Engineering (C.H., P.S.), School of Public Health (D.T.E.), and Division of Neurology (C.L., S.K.), University of Alberta, Edmonton; Division of Neurology (H.B.), University of British Columbia, Vancouver; Seaman Family MR Centre (R.F.) and Hotchkiss Brain Institute (R.F., L.K.), University of Calgary, Alberta; Montreal Neurological Institute (A.L.G.), McGill University, Quebec; and Sunnybrook Health Sciences Centre (S.J.G., L.Z.), University of Toronto, Ontario, Canada. .
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Źródło :
Neurology [Neurology] 2021 Aug 24; Vol. 97 (8), pp. e803-e813. Date of Electronic Publication: 2021 Jun 14.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Magnetic Resonance Spectroscopy*/methods
Amyotrophic Lateral Sclerosis/*metabolism
Aspartic Acid/*analogs & derivatives
Cognitive Dysfunction/*metabolism
Motor Cortex/*metabolism
Prefrontal Cortex/*metabolism
Adult ; Aged ; Amyotrophic Lateral Sclerosis/complications ; Amyotrophic Lateral Sclerosis/diagnostic imaging ; Amyotrophic Lateral Sclerosis/pathology ; Aspartic Acid/metabolism ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/pathology ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Motor Cortex/diagnostic imaging ; Motor Cortex/pathology ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/pathology ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Secondary Progressive Multiple Sclerosis: New Insights.
Autorzy :
Cree BAC; From the UCSF Weill Institute for Neurosciences, Department of Neurology (B.A.C.C.), University of California San Francisco; NeuroRx Research (D.L.A.), Montreal; Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, McGill University, Canada; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation (J.C.), UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London; National Institute for Health Research (J.C.), University College London Hospitals, Biomedical Research Centre, UK; Brigham Multiple Sclerosis Center (T.C.), Brigham and Women's Hospital, Boston, MA; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute (R.J.F.), Cleveland Clinic, OH; Oxford PharmaGenesis (A.P.R.), UK; Novartis Pharma AG (N.M.), Basel, Switzerland; and Center for Brain Research (H.L.), Medical University of Vienna, Austria. .
Arnold DL; From the UCSF Weill Institute for Neurosciences, Department of Neurology (B.A.C.C.), University of California San Francisco; NeuroRx Research (D.L.A.), Montreal; Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, McGill University, Canada; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation (J.C.), UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London; National Institute for Health Research (J.C.), University College London Hospitals, Biomedical Research Centre, UK; Brigham Multiple Sclerosis Center (T.C.), Brigham and Women's Hospital, Boston, MA; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute (R.J.F.), Cleveland Clinic, OH; Oxford PharmaGenesis (A.P.R.), UK; Novartis Pharma AG (N.M.), Basel, Switzerland; and Center for Brain Research (H.L.), Medical University of Vienna, Austria.
Chataway J; From the UCSF Weill Institute for Neurosciences, Department of Neurology (B.A.C.C.), University of California San Francisco; NeuroRx Research (D.L.A.), Montreal; Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, McGill University, Canada; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation (J.C.), UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London; National Institute for Health Research (J.C.), University College London Hospitals, Biomedical Research Centre, UK; Brigham Multiple Sclerosis Center (T.C.), Brigham and Women's Hospital, Boston, MA; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute (R.J.F.), Cleveland Clinic, OH; Oxford PharmaGenesis (A.P.R.), UK; Novartis Pharma AG (N.M.), Basel, Switzerland; and Center for Brain Research (H.L.), Medical University of Vienna, Austria.
Chitnis T; From the UCSF Weill Institute for Neurosciences, Department of Neurology (B.A.C.C.), University of California San Francisco; NeuroRx Research (D.L.A.), Montreal; Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, McGill University, Canada; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation (J.C.), UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London; National Institute for Health Research (J.C.), University College London Hospitals, Biomedical Research Centre, UK; Brigham Multiple Sclerosis Center (T.C.), Brigham and Women's Hospital, Boston, MA; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute (R.J.F.), Cleveland Clinic, OH; Oxford PharmaGenesis (A.P.R.), UK; Novartis Pharma AG (N.M.), Basel, Switzerland; and Center for Brain Research (H.L.), Medical University of Vienna, Austria.
Fox RJ; From the UCSF Weill Institute for Neurosciences, Department of Neurology (B.A.C.C.), University of California San Francisco; NeuroRx Research (D.L.A.), Montreal; Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, McGill University, Canada; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation (J.C.), UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London; National Institute for Health Research (J.C.), University College London Hospitals, Biomedical Research Centre, UK; Brigham Multiple Sclerosis Center (T.C.), Brigham and Women's Hospital, Boston, MA; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute (R.J.F.), Cleveland Clinic, OH; Oxford PharmaGenesis (A.P.R.), UK; Novartis Pharma AG (N.M.), Basel, Switzerland; and Center for Brain Research (H.L.), Medical University of Vienna, Austria.
Pozo Ramajo A; From the UCSF Weill Institute for Neurosciences, Department of Neurology (B.A.C.C.), University of California San Francisco; NeuroRx Research (D.L.A.), Montreal; Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, McGill University, Canada; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation (J.C.), UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London; National Institute for Health Research (J.C.), University College London Hospitals, Biomedical Research Centre, UK; Brigham Multiple Sclerosis Center (T.C.), Brigham and Women's Hospital, Boston, MA; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute (R.J.F.), Cleveland Clinic, OH; Oxford PharmaGenesis (A.P.R.), UK; Novartis Pharma AG (N.M.), Basel, Switzerland; and Center for Brain Research (H.L.), Medical University of Vienna, Austria.
Murphy N; From the UCSF Weill Institute for Neurosciences, Department of Neurology (B.A.C.C.), University of California San Francisco; NeuroRx Research (D.L.A.), Montreal; Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, McGill University, Canada; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation (J.C.), UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London; National Institute for Health Research (J.C.), University College London Hospitals, Biomedical Research Centre, UK; Brigham Multiple Sclerosis Center (T.C.), Brigham and Women's Hospital, Boston, MA; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute (R.J.F.), Cleveland Clinic, OH; Oxford PharmaGenesis (A.P.R.), UK; Novartis Pharma AG (N.M.), Basel, Switzerland; and Center for Brain Research (H.L.), Medical University of Vienna, Austria.
Lassmann H; From the UCSF Weill Institute for Neurosciences, Department of Neurology (B.A.C.C.), University of California San Francisco; NeuroRx Research (D.L.A.), Montreal; Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, McGill University, Canada; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation (J.C.), UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London; National Institute for Health Research (J.C.), University College London Hospitals, Biomedical Research Centre, UK; Brigham Multiple Sclerosis Center (T.C.), Brigham and Women's Hospital, Boston, MA; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute (R.J.F.), Cleveland Clinic, OH; Oxford PharmaGenesis (A.P.R.), UK; Novartis Pharma AG (N.M.), Basel, Switzerland; and Center for Brain Research (H.L.), Medical University of Vienna, Austria.
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Źródło :
Neurology [Neurology] 2021 Aug 24; Vol. 97 (8), pp. 378-388. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Biomarkers*
Disease Progression*
Immunologic Factors/*pharmacology
Multiple Sclerosis, Chronic Progressive/*diagnosis
Humans ; Multiple Sclerosis, Chronic Progressive/immunology ; Multiple Sclerosis, Chronic Progressive/pathology ; Multiple Sclerosis, Chronic Progressive/physiopathology
Czasopismo naukowe

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