Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Dobrowolski, Curtis"" wg kryterium: Autor


Wyświetlanie 1-17 z 17
Tytuł :
A Phase 1/2 Randomized, Placebo-Controlled Trial of Romidespin in Persons With HIV-1 on Suppressive Antiretroviral Therapy.
Autorzy :
McMahon DK; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Zheng L; Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Cyktor JC; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Aga E; Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Macatangay BJ; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Godfrey C; National Institutes of Health, Bethesda, Maryland, USA.
Para M; Ohio State University, Columbus, Ohio, USA.
Mitsuyasu RT; University of California Los Angeles, Los Angeles, California, USA.
Hesselgesser J; Gilead Sciences, Inc., Foster City, California, USA.
Dragavon J; University of Washington, Seattle, Washington, USA.
Dobrowolski C; Case Western Reserve University, Cleveland, Ohio, USA.
Karn J; Case Western Reserve University, Cleveland, Ohio, USA.
Acosta EP; University of Alabama at Birmingham, Birmingham, Alabama, USA.
Gandhi RT; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Mellors JW; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Pokaż więcej
Źródło :
The Journal of infectious diseases [J Infect Dis] 2021 Aug 16; Vol. 224 (4), pp. 648-656.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Therapeutic RNA Delivery for COVID and Other Diseases.
Autorzy :
Dobrowolski C; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA.
Paunovska K; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA.
Hatit MZC; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA.
Lokugamage MP; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA.
Dahlman JE; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA.
Pokaż więcej
Źródło :
Advanced healthcare materials [Adv Healthc Mater] 2021 Aug; Vol. 10 (15), pp. e2002022. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
COVID-19*
Nanoparticles*
Animals ; Drug Delivery Systems ; Humans ; Lipids ; RNA, Small Interfering/genetics ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
A phase I/II randomized, placebo-controlled trial of romidepsin in persons with HIV-1 on suppressive antiretroviral therapy to assess safety and activation of HIV-1 expression (A5315).
Autorzy :
McMahon DK; University of Pittsburgh, Pittsburgh, PA.
Zheng L; Harvard TH Chan School of Public Health, Boston, MA.
Cyktor JC; University of Pittsburgh, Pittsburgh, PA.
Aga E; Harvard TH Chan School of Public Health, Boston, MA.
Macatangay BJ; University of Pittsburgh, Pittsburgh, PA.
Godfrey C; National Institutes of Health, Bethesda, MD.
Para M; The Ohio State University, Columbus, OH.
Mitsuyasu RT; University of California Los Angeles, Los Angeles, CA.
Hesselgesser J; Gilead Sciences, Inc., Foster City, CA.
Dragavon J; University of Washington, Seattle, WA.
Dobrowolski C; Case Western Reserve University, Cleveland, OH.
Karn J; Case Western Reserve University, Cleveland, OH.
Acosta EP; University of Alabama at Birmingham, Birmingham, AL.
Gandhi RT; Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Mellors JW; University of Pittsburgh, Pittsburgh, PA.
Pokaż więcej
Corporate Authors :
ACTG A5315 Team
Źródło :
The Journal of infectious diseases [J Infect Dis] 2020 Dec 22. Date of Electronic Publication: 2020 Dec 22.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Entry of Polarized Effector Cells into Quiescence Forces HIV Latency.
Autorzy :
Dobrowolski C; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Valadkhan S; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Graham AC; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Shukla M; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Ciuffi A; Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Telenti A; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Karn J; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA .
Pokaż więcej
Źródło :
MBio [mBio] 2019 Mar 26; Vol. 10 (2). Date of Electronic Publication: 2019 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Activation*
Virus Latency*
CD4-Positive T-Lymphocytes/*virology
HIV/*physiology
HIV Infections/*virology
T-Lymphocyte Subsets/*virology
Cells, Cultured ; Cytokines/metabolism ; Flow Cytometry ; Humans ; Models, Biological
Czasopismo naukowe
Tytuł :
Sex-Based Differences in Human Immunodeficiency Virus Type 1 Reservoir Activity and Residual Immune Activation.
Autorzy :
Scully EP; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge.; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts.; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Gandhi M; Department of Medicine, University of California, San Francisco.
Johnston R; amfAR, The Foundation for AIDS Research, New York, New York.
Hoh R; Department of Medicine, University of California, San Francisco.
Lockhart A; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge.
Dobrowolski C; Case Western Reserve University, Cleveland, Ohio.
Pagliuzza A; Research Centre, Centre Hospitalier de l'Université de Montréal and Université de Montréal, Quebec, Canada.
Milush JM; Department of Medicine, University of California, San Francisco.
Baker CA; Department of Medicine, University of California, San Francisco.
Girling V; Department of Medicine, University of California, San Francisco.
Ellefson A; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Gorelick R; AIDS and Cancer Virus Program, Leidos Biomedical Research Inc, Frederick National Laboratory for Cancer Research, Maryland.
Lifson J; AIDS and Cancer Virus Program, Leidos Biomedical Research Inc, Frederick National Laboratory for Cancer Research, Maryland.
Altfeld M; Heinrich Pette Institut, Hamburg, Germany.
Alter G; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge.
Cedars M; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.
Solomon A; Peter Doherty Institute of Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Lewin SR; Peter Doherty Institute of Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
Karn J; Case Western Reserve University, Cleveland, Ohio.
Chomont N; Research Centre, Centre Hospitalier de l'Université de Montréal and Université de Montréal, Quebec, Canada.
Bacchetti P; Department of Epidemiology and Biostatistics, University of California, San Francisco.
Deeks SG; Department of Medicine, University of California, San Francisco.
Pokaż więcej
Źródło :
The Journal of infectious diseases [J Infect Dis] 2019 Mar 15; Vol. 219 (7), pp. 1084-1094.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV-1*
Viral Load*
CD4-Positive T-Lymphocytes/*physiology
DNA, Viral/*blood
HIV Infections/*immunology
RNA, Viral/*blood
Adult ; Anti-HIV Agents/therapeutic use ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Female ; HIV Infections/drug therapy ; HIV Infections/virology ; Humans ; Lymphocyte Activation ; Male ; Middle Aged ; Programmed Cell Death 1 Receptor/blood ; Prospective Studies ; Receptors, CCR5/metabolism ; Sex Factors
Czasopismo naukowe
Tytuł :
The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells.
Autorzy :
Alvarez-Carbonell D; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Ye F; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Ramanath N; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Dobrowolski C; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Karn J; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, USA. .
Pokaż więcej
Źródło :
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2019 Mar; Vol. 14 (1), pp. 94-109. Date of Electronic Publication: 2018 Jul 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV/*physiology
HIV Infections/*virology
Microglia/*virology
Receptors, Glucocorticoid/*metabolism
Virus Latency/*physiology
Cell Culture Techniques ; Cells, Cultured ; HIV Infections/metabolism ; Humans ; Microglia/metabolism ; Virus Activation ; Virus Replication/physiology
Czasopismo naukowe
Tytuł :
Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir.
Autorzy :
Das B; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Dobrowolski C; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Luttge B; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Valadkhan S; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Chomont N; Université de Montréal Hospital Research Centre, Université de Montréal, Montreal, QC H3T 1J4, Canada.; Department of Microbiology, Infectious Diseases, and Immunology, Université de Montréal, Montreal, QC H2X 3H8, Canada.
Johnston R; amfAR, The Foundation for AIDS Research, New York, NY 10005.
Bacchetti P; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158.
Hoh R; Division of HIV, Infectious Diseases and Global Medicine, Department of Medicine, University of California, San Francisco, CA 94110.
Gandhi M; Division of HIV, Infectious Diseases and Global Medicine, Department of Medicine, University of California, San Francisco, CA 94110.
Deeks SG; Division of HIV, Infectious Diseases and Global Medicine, Department of Medicine, University of California, San Francisco, CA 94110.
Scully E; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD 21218.
Karn J; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Aug 14; Vol. 115 (33), pp. E7795-E7804. Date of Electronic Publication: 2018 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Sex Characteristics*
Estrogen Receptor Modulators/*pharmacology
Estrogen Receptor alpha/*agonists
HIV-1/*physiology
Transcription, Genetic/*drug effects
Virus Latency/*drug effects
Adult ; Estrogen Receptor alpha/metabolism ; Female ; Humans ; Jurkat Cells ; Male ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology
Czasopismo naukowe
Tytuł :
A Targeted Mass Spectrometry Assay for Detection of HIV Gag Protein Following Induction of Latent Viral Reservoirs.
Autorzy :
Schlatzer D; Center for Proteomics and Bioinformatics, Department of Nutrition, ‡Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University , Cleveland, Ohio 44106, United States.
Haqqani AA; Center for Proteomics and Bioinformatics, Department of Nutrition, ‡Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University , Cleveland, Ohio 44106, United States.
Li X; Center for Proteomics and Bioinformatics, Department of Nutrition, ‡Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University , Cleveland, Ohio 44106, United States.
Dobrowolski C; Center for Proteomics and Bioinformatics, Department of Nutrition, ‡Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University , Cleveland, Ohio 44106, United States.
Chance MR; Center for Proteomics and Bioinformatics, Department of Nutrition, ‡Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University , Cleveland, Ohio 44106, United States.
Tilton JC; Center for Proteomics and Bioinformatics, Department of Nutrition, ‡Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University , Cleveland, Ohio 44106, United States.
Pokaż więcej
Źródło :
Analytical chemistry [Anal Chem] 2017 May 16; Vol. 89 (10), pp. 5325-5332. Date of Electronic Publication: 2017 May 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Tandem Mass Spectrometry*
CD4-Positive T-Lymphocytes/*virology
HIV-1/*metabolism
gag Gene Products, Human Immunodeficiency Virus/*analysis
Anti-HIV Agents/therapeutic use ; Antibodies, Monoclonal/immunology ; CD4-Positive T-Lymphocytes/cytology ; Chromatography, High Pressure Liquid ; Genotype ; HIV Infections/drug therapy ; HIV Infections/pathology ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/isolation & purification ; Humans ; Immunoprecipitation ; Limit of Detection ; Peptides/analysis ; Peptides/chemistry ; gag Gene Products, Human Immunodeficiency Virus/immunology ; gag Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency.
Autorzy :
Nguyen K; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Das B; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Dobrowolski C; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Karn J; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA .
Pokaż więcej
Źródło :
MBio [mBio] 2017 Feb 28; Vol. 8 (1). Date of Electronic Publication: 2017 Feb 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Virus Latency*
Enhancer of Zeste Homolog 2 Protein/*metabolism
HIV-1/*physiology
Histocompatibility Antigens/*metabolism
Histone-Lysine N-Methyltransferase/*metabolism
Histones/*metabolism
Cells, Cultured ; Chromatin Immunoprecipitation ; Humans ; Methylation
Czasopismo naukowe
Tytuł :
Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells.
Autorzy :
Alvarez-Carbonell D; Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave., SOM WRT 200, Cleveland, OH, 44106, USA.
Garcia-Mesa Y; Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave., SOM WRT 200, Cleveland, OH, 44106, USA.
Milne S; Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave., SOM WRT 200, Cleveland, OH, 44106, USA.
Das B; Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave., SOM WRT 200, Cleveland, OH, 44106, USA.
Dobrowolski C; Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave., SOM WRT 200, Cleveland, OH, 44106, USA.
Rojas R; Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave., SOM WRT 200, Cleveland, OH, 44106, USA.
Karn J; Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave., SOM WRT 200, Cleveland, OH, 44106, USA. .
Pokaż więcej
Źródło :
Retrovirology [Retrovirology] 2017 Feb 06; Vol. 14 (1), pp. 9. Date of Electronic Publication: 2017 Feb 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Virus Latency*
HIV-1/*physiology
Microglia/*virology
Toll-Like Receptor 3/*metabolism
Animals ; Cell Line ; Cells, Cultured ; Humans ; Lipopolysaccharides/pharmacology ; Microglia/drug effects ; Monocytes/drug effects ; Monocytes/virology ; NF-kappa B/metabolism ; Poly I-C/pharmacology ; RNA, Bacterial/pharmacology ; RNA, Ribosomal/pharmacology ; Rats ; Signal Transduction/drug effects ; T-Lymphocytes/drug effects ; T-Lymphocytes/virology ; Toll-Like Receptor 2/agonists ; Toll-Like Receptor 3/agonists ; Toll-Like Receptor 4/agonists ; Toll-Like Receptors/agonists ; Virus Activation
Czasopismo naukowe
Tytuł :
Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system.
Autorzy :
Garcia-Mesa Y; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Jay TR; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Checkley MA; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Luttge B; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Dobrowolski C; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Valadkhan S; Department of Biochemistry, Case Western Reserve University, Cleveland, OH, 44106, USA.
Landreth GE; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Karn J; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Alvarez-Carbonell D; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, USA. .
Pokaż więcej
Źródło :
Journal of neurovirology [J Neurovirol] 2017 Feb; Vol. 23 (1), pp. 47-66. Date of Electronic Publication: 2016 Nov 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Founder Effect*
Transformation, Genetic*
Antigens, Viral, Tumor/*genetics
Microglia/*pathology
Adult ; Animals ; Antigens, Viral, Tumor/metabolism ; Biomarkers/metabolism ; Brain/metabolism ; Brain/pathology ; Brain/virology ; CD11b Antigen/genetics ; CD11b Antigen/metabolism ; Cell Movement ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Lentivirus/genetics ; Lentivirus/metabolism ; Macaca ; Mice ; Microglia/metabolism ; Microglia/virology ; Phagocytosis ; Primary Cell Culture ; Rats ; Receptors, Purinergic P2Y12/genetics ; Receptors, Purinergic P2Y12/metabolism ; Receptors, Transforming Growth Factor beta/genetics ; Receptors, Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
Novel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosis.
Autorzy :
Li Q; Department of Medicine, Case Western Reserve University &University Hospitals, Cleveland, Ohio, United States of America.
Karim AF; Department of Molecular Biology and Microbiology, Case Western Reserve University &University Hospitals, Cleveland, Ohio, United States of America.
Ding X; Department of Medicine, Case Western Reserve University &University Hospitals, Cleveland, Ohio, United States of America.
Das B; Department of Molecular Biology and Microbiology, Case Western Reserve University &University Hospitals, Cleveland, Ohio, United States of America.
Dobrowolski C; Department of Molecular Biology and Microbiology, Case Western Reserve University &University Hospitals, Cleveland, Ohio, United States of America.
Gibson RM; University Hospitals Translational Laboratory, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America.
Quiñones-Mateu ME; University Hospitals Translational Laboratory, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America.; Center for AIDS Research (CFAR), Case Western Reserve University &University Hospitals, Cleveland, Ohio, United States of America.; Department of Pathology, Case Western Reserve University &University Hospitals, Cleveland, Ohio, United States of America.
Karn J; Department of Molecular Biology and Microbiology, Case Western Reserve University &University Hospitals, Cleveland, Ohio, United States of America.; Center for AIDS Research (CFAR), Case Western Reserve University &University Hospitals, Cleveland, Ohio, United States of America.
Rojas RE; Department of Molecular Biology and Microbiology, Case Western Reserve University &University Hospitals, Cleveland, Ohio, United States of America.; Center for AIDS Research (CFAR), Case Western Reserve University &University Hospitals, Cleveland, Ohio, United States of America.
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2016 Jun 14; Vol. 6, pp. 27566. Date of Electronic Publication: 2016 Jun 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antitubercular Agents/*pharmacology
Dicumarol/*pharmacology
Host-Pathogen Interactions/*drug effects
Macrophages/*immunology
Mycobacterium tuberculosis/*drug effects
NAD(P)H Dehydrogenase (Quinone)/*genetics
Drug Synergism ; Enzyme Inhibitors/pharmacology ; Gene Expression Regulation ; Gene Library ; High-Throughput Nucleotide Sequencing ; High-Throughput Screening Assays ; Humans ; Interleukin-1beta/agonists ; Interleukin-1beta/genetics ; Interleukin-1beta/immunology ; Macrophages/drug effects ; Macrophages/microbiology ; Mycobacterium tuberculosis/pathogenicity ; Mycobacterium tuberculosis/physiology ; NAD(P)H Dehydrogenase (Quinone)/antagonists & inhibitors ; NAD(P)H Dehydrogenase (Quinone)/immunology ; NF-kappa B/agonists ; NF-kappa B/genetics ; NF-kappa B/immunology ; Primary Cell Culture ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Rifampin/pharmacology ; Signal Transduction ; THP-1 Cells ; Tumor Necrosis Factor-alpha/agonists ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology
Czasopismo naukowe
Tytuł :
Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.
Autorzy :
Das B; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States.
Dobrowolski C; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States.
Shahir AM; Department of Periodontics, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, United States.
Feng Z; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States.
Yu X; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States.
Sha J; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States.
Bissada NF; Department of Periodontics, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, United States.
Weinberg A; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States.
Karn J; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States. Electronic address: .
Ye F; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States. Electronic address: .
Pokaż więcej
Źródło :
Virology [Virology] 2015 Jan 01; Vol. 474, pp. 65-81. Date of Electronic Publication: 2014 Nov 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Fatty Acids, Volatile/*metabolism
HIV-1/*physiology
Histones/*metabolism
Positive Transcriptional Elongation Factor B/*metabolism
T-Lymphocytes/*metabolism
T-Lymphocytes/*virology
Virus Latency/*physiology
Acetylation ; Bacteria/metabolism ; Cells, Cultured ; Enhancer of Zeste Homolog 2 Protein ; Gene Knockdown Techniques ; HIV Infections/complications ; HIV Infections/metabolism ; HIV Infections/virology ; HIV Long Terminal Repeat ; HIV-1/genetics ; HIV-1/pathogenicity ; Histone Deacetylases/metabolism ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/physiology ; Humans ; Jurkat Cells ; Methyltransferases/metabolism ; Models, Biological ; Periodontitis/complications ; Periodontitis/metabolism ; Periodontitis/microbiology ; Polycomb Repressive Complex 2/metabolism ; Repressor Proteins/metabolism ; Saliva/metabolism ; Saliva/virology ; Sirtuin 1/antagonists & inhibitors ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Transcriptional Activation ; Virus Activation/physiology ; Virus Latency/genetics
Czasopismo naukowe
Tytuł :
The histone deacetylase inhibitor vorinostat (SAHA) increases the susceptibility of uninfected CD4+ T cells to HIV by increasing the kinetics and efficiency of postentry viral events.
Autorzy :
Lucera MB; Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Tilton CA; Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Mao H; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Dobrowolski C; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Tabler CO; Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Haqqani AA; Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Karn J; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Tilton JC; Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA .
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2014 Sep; Vol. 88 (18), pp. 10803-12. Date of Electronic Publication: 2014 Jul 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*virology
HIV Infections/*virology
HIV-1/*drug effects
HIV-1/*physiology
Histone Deacetylase Inhibitors/*pharmacology
Hydroxamic Acids/*pharmacology
CD4-Positive T-Lymphocytes/chemistry ; CD4-Positive T-Lymphocytes/drug effects ; Gene Expression Regulation, Viral/drug effects ; HIV Long Terminal Repeat ; HIV-1/genetics ; Humans ; Kinetics ; Reverse Transcription/drug effects ; Virus Integration/drug effects ; Virus Latency/drug effects ; Virus Replication/drug effects ; Vorinostat
Czasopismo naukowe
Tytuł :
Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat.
Autorzy :
Jadlowsky JK; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Wong JY
Graham AC
Dobrowolski C
Devor RL
Adams MD
Fujinaga K
Karn J
Pokaż więcej
Źródło :
Molecular and cellular biology [Mol Cell Biol] 2014 Jun; Vol. 34 (11), pp. 1911-28. Date of Electronic Publication: 2014 Mar 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation, Viral*
HIV-1/*physiology
Proviruses/*physiology
RNA Polymerase II/*genetics
Transcription Factors/*physiology
Virus Latency/*genetics
Cell Line, Tumor ; Chromatin Immunoprecipitation ; HIV Long Terminal Repeat/genetics ; HIV-1/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Jurkat Cells ; Promoter Regions, Genetic ; Proviruses/genetics ; RNA Interference ; RNA Polymerase II/biosynthesis ; RNA Polymerase II/metabolism ; RNA, Small Interfering ; Sequence Analysis, DNA ; Transcription Factors/genetics ; Transcription, Genetic ; Tumor Necrosis Factor-alpha/metabolism ; rev Gene Products, Human Immunodeficiency Virus/genetics ; rev Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.
Autorzy :
Mbonye UR; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Gokulrangan G
Datt M
Dobrowolski C
Cooper M
Chance MR
Karn J
Pokaż więcej
Źródło :
PLoS pathogens [PLoS Pathog] 2013; Vol. 9 (5), pp. e1003338. Date of Electronic Publication: 2013 May 02.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
CD4-Positive T-Lymphocytes/*metabolism
Cyclin-Dependent Kinase 9/*metabolism
HIV/*metabolism
HIV Infections/*metabolism
Positive Transcriptional Elongation Factor B/*metabolism
Proviruses/*metabolism
Biomarkers/metabolism ; CD4-Positive T-Lymphocytes/virology ; Cell Cycle Proteins ; Cyclin T/genetics ; Cyclin T/metabolism ; Cyclin-Dependent Kinase 9/genetics ; Female ; HIV/genetics ; HIV Infections/genetics ; Humans ; Male ; Mutation ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phosphorylation/genetics ; Positive Transcriptional Elongation Factor B/genetics ; Protein Binding/genetics ; Proviruses/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; tat Gene Products, Human Immunodeficiency Virus/genetics ; tat Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Methamphetamine activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and induces human immunodeficiency virus (HIV) transcription in human microglial cells.
Autorzy :
Wires ES; Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
Alvarez D
Dobrowolski C
Wang Y
Morales M
Karn J
Harvey BK
Pokaż więcej
Źródło :
Journal of neurovirology [J Neurovirol] 2012 Oct; Vol. 18 (5), pp. 400-10. Date of Electronic Publication: 2012 May 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
Gene Expression Regulation, Viral/*drug effects
HIV-1/*drug effects
Methamphetamine/*adverse effects
Microglia/*drug effects
NF-kappa B/*metabolism
tat Gene Products, Human Immunodeficiency Virus/*genetics
Antigens, Polyomavirus Transforming/genetics ; Cell Nucleus/metabolism ; Cell Nucleus/virology ; HIV Long Terminal Repeat ; HIV-1/genetics ; HIV-1/metabolism ; Humans ; Microglia/metabolism ; Microglia/virology ; NF-kappa B/genetics ; Primary Cell Culture ; Promoter Regions, Genetic ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Protein Transport/drug effects ; Signal Transduction ; Transcription, Genetic/drug effects ; Transfection ; tat Gene Products, Human Immunodeficiency Virus/agonists ; tat Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
    Wyświetlanie 1-17 z 17

    Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies