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Tytuł :
Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis.
Autorzy :
Beddows CA; Department of Anatomy and Physiology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC, Australia.
Dodd GT; Department of Anatomy and Physiology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC, Australia.
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Źródło :
Journal of neuroendocrinology [J Neuroendocrinol] 2021 Apr; Vol. 33 (4), pp. e12947. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance.
Autorzy :
Dodd GT; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia. garron.dodd@unimelb.edu.au .; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Kim SJ; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Méquinion M; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Physiology, Monash University, VIC 3800, Australia.
Xirouchaki CE; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Brüning JC; Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Str. 50, 50931 Cologne, Germany.; Center for Endocrinology, Diabetes, and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Str. 26, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; National Center for Diabetes Research (DZD), Ingolstädter Land Str. 1, 85764 Neuherberg, Germany.
Andrews ZB; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Physiology, Monash University, VIC 3800, Australia.
Tiganis T; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia. garron.dodd@unimelb.edu.au .; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.; Monash Metabolic Phenotyping Facility, Monash University, VIC, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
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Źródło :
Science advances [Sci Adv] 2021 Feb 26; Vol. 7 (9). Date of Electronic Publication: 2021 Feb 26 (Print Publication: 2021).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling.
Autorzy :
Worth AA; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
Shoop R; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
Tye K; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
Feetham CH; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
D'Agostino G; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Rowett Institute, University of Aberdeen, Aberdeen, United Kingdom.
Dodd GT; School of Biomedical Sciences, The University of Melbourne, Victoria, Australia.
Reimann F; Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
Gribble FM; Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
Beebe EC; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Dunbar JD; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Alexander-Chacko JT; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Sindelar DK; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Coskun T; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Emmerson PJ; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, United States.
Luckman SM; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
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Źródło :
ELife [Elife] 2020 Jul 29; Vol. 9. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Anorexia/*genetics
Brain Stem/*physiology
Growth Differentiation Factor 15/*genetics
Neurons/*physiology
Pica/*genetics
Animals ; Cholecystokinin/metabolism ; Growth Differentiation Factor 15/administration & dosage ; Growth Differentiation Factor 15/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/administration & dosage
Czasopismo naukowe
Tytuł :
A Neural basis for Octanoic acid regulation of energy balance.
Autorzy :
Haynes VR; Department of Physiology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, 3010, VIC, Australia; Metabolic Disease, Obesity and Diabetes Program, Biomedicine Discovery Institute and the Department of Physiology, Monash University, Clayton, 3800, VIC, Australia.
Michael NJ; Metabolic Disease, Obesity and Diabetes Program, Biomedicine Discovery Institute and the Department of Physiology, Monash University, Clayton, 3800, VIC, Australia; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
van den Top M; NeuroSolutions Ltd, Coventry, UK.
Zhao FY; NeuroSolutions Ltd, Coventry, UK.
Brown RD; Metabolic Disease, Obesity and Diabetes Program, Biomedicine Discovery Institute and the Department of Physiology, Monash University, Clayton, 3800, VIC, Australia.
De Souza D; Metabolomics Australia, Bio21 Institute, University of Melbourne, Parkville, 3010, VIC, Australia.
Dodd GT; Department of Physiology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, 3010, VIC, Australia.
Spanswick D; Metabolic Disease, Obesity and Diabetes Program, Biomedicine Discovery Institute and the Department of Physiology, Monash University, Clayton, 3800, VIC, Australia; Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK; NeuroSolutions Ltd, Coventry, UK. Electronic address: .
Watt MJ; Department of Physiology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, 3010, VIC, Australia. Electronic address: .
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Źródło :
Molecular metabolism [Mol Metab] 2020 Apr; Vol. 34, pp. 54-71. Date of Electronic Publication: 2020 Jan 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Energy Metabolism*
Caprylates/*metabolism
Neurons/*metabolism
Animals ; Male ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
Autorzy :
Wiede F; Monash Biomedicine Discovery Institute, Monash University, Clayton, Vic., Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic., Australia.; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
Lu KH; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
Du X; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic., Australia.
Liang S; Monash Biomedicine Discovery Institute, Monash University, Clayton, Vic., Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic., Australia.; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
Hochheiser K; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.; Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Vic., Australia.; Peter Doherty Institute for Infection and Immunity, Melbourne, Vic., Australia.
Dodd GT; Monash Biomedicine Discovery Institute, Monash University, Clayton, Vic., Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic., Australia.
Goh PK; Monash Biomedicine Discovery Institute, Monash University, Clayton, Vic., Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic., Australia.; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
Kearney C; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
Meyran D; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
Beavis PA; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic., Australia.
Henderson MA; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
Park SL; Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Vic., Australia.; Peter Doherty Institute for Infection and Immunity, Melbourne, Vic., Australia.
Waithman J; Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
Zhang S; Department of Medicinal Chemistry and Molecular Pharmacology, Institute for Drug Discovery, Purdue University, West Lafayette, IN, USA.
Zhang ZY; Department of Medicinal Chemistry and Molecular Pharmacology, Institute for Drug Discovery, Purdue University, West Lafayette, IN, USA.
Oliaro J; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic., Australia.
Gebhardt T; Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Vic., Australia.; Peter Doherty Institute for Infection and Immunity, Melbourne, Vic., Australia.
Darcy PK; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic., Australia.
Tiganis T; Monash Biomedicine Discovery Institute, Monash University, Clayton, Vic., Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic., Australia.; Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
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Źródło :
The EMBO journal [EMBO J] 2020 Jan 15; Vol. 39 (2), pp. e103637. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Immunotherapy, Adoptive/*methods
Lymphocyte Activation/*immunology
Neoplasms/*therapy
Protein Tyrosine Phosphatase, Non-Receptor Type 2/*physiology
Receptor, ErbB-2/*physiology
Receptors, Antigen, T-Cell/*immunology
Adoptive Transfer ; Animals ; Antigen Presentation/immunology ; Female ; Humans ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Neoplasms/genetics ; Neoplasms/immunology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity.
Autorzy :
Dodd GT; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Xirouchaki CE; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Eramo M; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Mitchell CA; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Andrews ZB; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Physiology, Monash University, VIC 3800, Australia.
Henry BA; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Physiology, Monash University, VIC 3800, Australia.
Cowley MA; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Physiology, Monash University, VIC 3800, Australia.
Tiganis T; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Monash Metabolic Phenotyping Facility, Monash University, VIC, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Sep 10; Vol. 28 (11), pp. 2905-2922.e5.
Typ publikacji :
Journal Article
MeSH Terms :
Hypothalamus/*metabolism
Insulin Resistance/*genetics
Leptin/*metabolism
Obesity/*metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 2/*metabolism
Weight Loss/*genetics
Adipose Tissue, White/metabolism ; Administration, Intranasal ; Animals ; Blood-Brain Barrier/metabolism ; Cholestanes/administration & dosage ; Diet, High-Fat ; Feeding Behavior/drug effects ; Gliosis/genetics ; Gliosis/metabolism ; Glucocorticoids/pharmacology ; Hypothalamus/drug effects ; Leptin/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mifepristone/administration & dosage ; Obesity/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors ; Spermine/administration & dosage ; Spermine/analogs & derivatives
Czasopismo naukowe
Tytuł :
Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice.
Autorzy :
Balland E; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
Chen W; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
Dodd GT; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.
Conductier G; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
Coppari R; Department of Cell Physiology and Metabolism, University of Geneva, Rue Michel Servet 1, Geneva, Switzerland; Diabetes Center of the Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland.
Tiganis T; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia. Electronic address: .
Cowley MA; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Jan 08; Vol. 26 (2), pp. 346-355.e3.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gluconeogenesis*
Arcuate Nucleus of Hypothalamus/*metabolism
Insulin/*metabolism
Leptin/*metabolism
Liver/*metabolism
Obesity/*metabolism
Animals ; Diet, High-Fat/adverse effects ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/etiology ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Autorzy :
Kyriakou E; Institute of Structural Biology , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; Biomolecular NMR and Center for Integrated Protein Science Munich at Department of Chemistry , Technical University of Munich , 85747 Garching , Germany.
Schmidt S; Institute of Structural Biology , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; Biomolecular NMR and Center for Integrated Protein Science Munich at Department of Chemistry , Technical University of Munich , 85747 Garching , Germany.
Dodd GT; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology , Monash University , Victoria 3800 , Australia.
Pfuhlmann K; Research Unit Neurobiology of Diabetes , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; Institute for Diabetes and Obesity , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; Division of Metabolic Diseases , Technische Universität München , 80333 Munich , Germany.; German Center for Diabetes Research (DZD) , 85764 Neuherberg , Germany.
Simonds SE; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, and Department of Physiology , Monash University , Victoria 3800 , Australia.
Lenhart D; Institute of Structural Biology , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; Biomolecular NMR and Center for Integrated Protein Science Munich at Department of Chemistry , Technical University of Munich , 85747 Garching , Germany.; Institute of Medicinal Chemistry , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
Geerlof A; Institute of Structural Biology , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
Schriever SC; Research Unit Neurobiology of Diabetes , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; Institute for Diabetes and Obesity , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; German Center for Diabetes Research (DZD) , 85764 Neuherberg , Germany.
De Angelis M; Molecular EXposomics , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
Schramm KW; Molecular EXposomics , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
Plettenburg O; Institute of Medicinal Chemistry , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; Institute of Organic Chemistry , Leibniz Universität Hannover , 30167 Hannover , Germany.
Cowley MA; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, and Department of Physiology , Monash University , Victoria 3800 , Australia.
Tiganis T; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology , Monash University , Victoria 3800 , Australia.; Peter MacCallum Cancer Centre , Melbourne , Victoria 3000 , Australia.
Tschöp MH; Institute for Diabetes and Obesity , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; Division of Metabolic Diseases , Technische Universität München , 80333 Munich , Germany.; German Center for Diabetes Research (DZD) , 85764 Neuherberg , Germany.
Pfluger PT; Research Unit Neurobiology of Diabetes , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; Institute for Diabetes and Obesity , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; German Center for Diabetes Research (DZD) , 85764 Neuherberg , Germany.
Sattler M; Institute of Structural Biology , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; Biomolecular NMR and Center for Integrated Protein Science Munich at Department of Chemistry , Technical University of Munich , 85747 Garching , Germany.
Messias AC; Institute of Structural Biology , Helmholtz Zentrum München , 85764 Neuherberg , Germany.; Biomolecular NMR and Center for Integrated Protein Science Munich at Department of Chemistry , Technical University of Munich , 85747 Garching , Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2018 Dec 27; Vol. 61 (24), pp. 11144-11157. Date of Electronic Publication: 2018 Dec 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Obesity Agents/*pharmacology
Obesity/*drug therapy
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 2/*antagonists & inhibitors
Triterpenes/*pharmacology
Allosteric Site ; Animals ; Anti-Obesity Agents/metabolism ; Catalytic Domain ; Diet, High-Fat/adverse effects ; Hypothalamus/drug effects ; Hypothalamus/metabolism ; Magnetic Resonance Spectroscopy ; Male ; Mice, Transgenic ; Obesity/etiology ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/metabolism ; Structure-Activity Relationship ; Triterpenes/chemistry ; Triterpenes/metabolism ; Weight Loss/drug effects
Czasopismo naukowe
Tytuł :
Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.
Autorzy :
Grohmann M; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Wiede F; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Dodd GT; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Gurzov EN; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Ooi GJ; Monash University Department of Surgery, Alfred Hospital, Melbourne, VIC 3004, Australia.
Butt T; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Rasmiena AA; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Kaur S; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Gulati T; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Goh PK; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Treloar AE; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Archer S; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Monash Bioinformations Platform, Monash University, Clayton, VIC 3800, Australia.
Brown WA; Monash University Department of Surgery, Alfred Hospital, Melbourne, VIC 3004, Australia.
Muller M; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
Watt MJ; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Ohara O; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; Kazusa DNA Research Institute Kisarazu, Chiba 292-0818, Japan.
McLean CA; Anatomical Pathology, Alfred Hospital, Prahran, VIC 3004, Australia.
Tiganis T; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia. Electronic address: .
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Źródło :
Cell [Cell] 2018 Nov 15; Vol. 175 (5), pp. 1289-1306.e20. Date of Electronic Publication: 2018 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
Non-alcoholic Fatty Liver Disease/*pathology
Obesity/*pathology
STAT1 Transcription Factor/*metabolism
STAT3 Transcription Factor/*metabolism
Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Carcinoma, Hepatocellular/metabolism ; Diet, High-Fat ; Disease Models, Animal ; Hepatocytes/metabolism ; Humans ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Liver Neoplasms/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/metabolism ; Obesity/metabolism ; Oxidative Stress ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/deficiency ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Insulin regulates POMC neuronal plasticity to control glucose metabolism.
Autorzy :
Dodd GT; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia.
Michael NJ; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; Department of Physiology, Monash University, Victoria, Australia.
Lee-Young RS; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia.; Monash Metabolic Phenotyping Facility, Monash University, Victoria, Australia.
Mangiafico SP; Department of Medicine (Austin Hospital), The University of Melbourne, Melbourne, Australia.
Pryor JT; Department of Physiology, Monash University, Victoria, Australia.; Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Munder AC; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; Department of Physiology, Monash University, Victoria, Australia.
Simonds SE; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; Department of Physiology, Monash University, Victoria, Australia.
Brüning JC; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.; Center for Endocrinology, Diabetes, and Preventive Medicine, University Hospital Cologne, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; National Center for Diabetes Research, Neuherberg, Germany.
Zhang ZY; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, United States.
Cowley MA; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; Department of Physiology, Monash University, Victoria, Australia.
Andrikopoulos S; Department of Medicine (Austin Hospital), The University of Melbourne, Melbourne, Australia.
Horvath TL; Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, United States.; Department of Anatomy and Histology, University of Veterinary Medicine, Hungary, Europe.
Spanswick D; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; Department of Physiology, Monash University, Victoria, Australia.; Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Tiganis T; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia.; Monash Metabolic Phenotyping Facility, Monash University, Victoria, Australia.
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Źródło :
ELife [Elife] 2018 Sep 19; Vol. 7. Date of Electronic Publication: 2018 Sep 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucose/*metabolism
Insulin/*pharmacology
Neuronal Plasticity/*drug effects
Neurons/*metabolism
Pro-Opiomelanocortin/*metabolism
Animals ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/pharmacology ; Hypothalamus/cytology ; Insulin/administration & dosage ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Neuronal Plasticity/genetics ; Pro-Opiomelanocortin/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/metabolism ; Receptor, Insulin/genetics ; Receptor, Insulin/metabolism
Czasopismo naukowe
Tytuł :
TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding.
Autorzy :
Dodd GT; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria, Australia .dodd@monash.edu.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, Victoria, Australia.
Lee-Young RS; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, Victoria, Australia.; Monash Metabolic Phenotyping Facility, Monash University, Clayton, Melbourne, Victoria, Australia.
Brüning JC; Department of Neuronal Control of Metabolism, Max Plank Institute for Metabolism Research, Cologne, Germany.; Center for Endocrinology, Diabetes, and Preventive Medicine (CEDP), University Hospital Cologne, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; National Center for Diabetes Research (DZD), Neuherberg, Germany.
Tiganis T; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria, Australia .dodd@monash.edu.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, Victoria, Australia.; Monash Metabolic Phenotyping Facility, Monash University, Clayton, Melbourne, Victoria, Australia.
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Źródło :
Diabetes [Diabetes] 2018 Jul; Vol. 67 (7), pp. 1246-1257. Date of Electronic Publication: 2018 Apr 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Agouti-Related Protein/*metabolism
Eating/*physiology
Gluconeogenesis/*genetics
Glucose/*metabolism
Insulin/*metabolism
Neurons/*metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 2/*physiology
Adipose Tissue, Brown/metabolism ; Animals ; Carbohydrate Metabolism/physiology ; Energy Metabolism/genetics ; Fasting ; Glucose Clamp Technique ; Liver/metabolism ; Mice ; Mice, Transgenic ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/genetics ; Receptor, Insulin/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Insulin action in the brain: Roles in energy and glucose homeostasis.
Autorzy :
Dodd GT; Metabolic Disease and Obesity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.
Tiganis T; Metabolic Disease and Obesity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.
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Źródło :
Journal of neuroendocrinology [J Neuroendocrinol] 2017 Oct; Vol. 29 (10).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Energy Metabolism*
Brain/*metabolism
Glucose/*metabolism
Insulin/*metabolism
Adiposity ; Animals ; Body Weight ; Diabetes Mellitus, Type 2 ; Feeding Behavior ; Humans ; Insulin Resistance ; Metabolic Diseases/metabolism ; Obesity
Czasopismo naukowe
Tytuł :
PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.
Autorzy :
Wiede F; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia .; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Dudakov JA; Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Lu KH; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Dodd GT; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Butt T; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Godfrey DI; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, Victoria, Australia.; Department of Microbiology and Immunology and Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.
Strasser A; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Boyd RL; Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Tiganis T; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia .; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2017 Sep 04; Vol. 214 (9), pp. 2733-2758. Date of Electronic Publication: 2017 Aug 10.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Lineage/*physiology
Protein Tyrosine Phosphatase, Non-Receptor Type 2/*physiology
Receptors, Antigen, T-Cell, alpha-beta/*physiology
Receptors, Antigen, T-Cell, gamma-delta/*physiology
T-Lymphocytes/*physiology
Animals ; Female ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Multipotent Stem Cells/physiology ; STAT5 Transcription Factor/physiology
Czasopismo naukowe
Tytuł :
A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding.
Autorzy :
Dodd GT; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.
Andrews ZB; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
Simonds SE; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
Michael NJ; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
DeVeer M; Monash Biomedical Imaging, Monash University, Victoria 3168, Australia.
Brüning JC; Max Plank Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Str. 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes, and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Str. 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Land Str. 1, 85764 Neuherberg, Germany.
Spanswick D; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
Cowley MA; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
Tiganis T; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia. Electronic address: .
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Źródło :
Cell metabolism [Cell Metab] 2017 Aug 01; Vol. 26 (2), pp. 375-393.e7.
Typ publikacji :
Journal Article
MeSH Terms :
Eating/*psychology
Energy Metabolism/*physiology
Hypothalamus/*metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 2/*biosynthesis
Agouti-Related Protein/genetics ; Agouti-Related Protein/metabolism ; Animals ; Mice ; Mice, Transgenic ; Neuropeptide Y/genetics ; Neuropeptide Y/metabolism ; Obesity/genetics ; Obesity/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/genetics
Czasopismo naukowe
Tytuł :
Erratum to: Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.
Autorzy :
Merry TL; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.; Faculty of Medical and Health Sciences, The University of Auckland, Aukland, New Zealand.
Tran M; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Dodd GT; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Mangiafico SP; Department of Medicine (Austin Hospital), The University of Melbourne, Melbourne, VIC, Australia.
Wiede F; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Kaur S; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
McLean CL; Department of Anatomical Pathology, Alfred Hospital, Prahran, VIC, Australia.
Andrikopoulos S; Department of Medicine (Austin Hospital), The University of Melbourne, Melbourne, VIC, Australia.
Tiganis T; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia. .
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Źródło :
Diabetologia [Diabetologia] 2016 Dec; Vol. 59 (12), pp. 2729.
Typ publikacji :
Journal Article; Published Erratum
Czasopismo naukowe
Tytuł :
Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.
Autorzy :
Merry TL; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.; Faculty of Medical and Health Sciences, The University of Auckland, Aukland, New Zealand.
Tran M; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Dodd GT; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Mangiafico SP; Department of Medicine (Austin Hospital), The University of Melbourne, Melbourne, VIC, Australia.
Wiede F; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Kaur S; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
McLean CL; Department of Anatomical Pathology, Alfred Hospital, Prahran, VIC, Australia.
Andrikopoulos S; Department of Medicine (Austin Hospital), The University of Melbourne, Melbourne, VIC, Australia.
Tiganis T; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia. .
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Źródło :
Diabetologia [Diabetologia] 2016 Dec; Vol. 59 (12), pp. 2632-2644. Date of Electronic Publication: 2016 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fatty Liver/*metabolism
Glucose/*metabolism
Glutathione Peroxidase/*deficiency
Glutathione Peroxidase/*metabolism
Liver/*metabolism
Non-alcoholic Fatty Liver Disease/*enzymology
Non-alcoholic Fatty Liver Disease/*metabolism
Alleles ; Animals ; Diabetes Mellitus, Type 2/enzymology ; Diabetes Mellitus, Type 2/metabolism ; Hepatocytes/metabolism ; Hydrogen Peroxide/metabolism ; Insulin Resistance/physiology ; Liver/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Polymerase Chain Reaction ; Protein Tyrosine Phosphatases/genetics ; Protein Tyrosine Phosphatases/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.
Autorzy :
Zhang ZY; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202-5126, USA.
Dodd GT; Department of Biochemistry and Molecular Biology, Monash University, VIC 3800, Australia.
Tiganis T; Department of Biochemistry and Molecular Biology, Monash University, VIC 3800, Australia. Electronic address: .
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Źródło :
Trends in pharmacological sciences [Trends Pharmacol Sci] 2015 Oct; Vol. 36 (10), pp. 661-674.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Signal Transduction*
Hypothalamus/*metabolism
Insulin/*metabolism
Leptin/*metabolism
Protein Tyrosine Phosphatases/*metabolism
Animals ; Humans ; Protein Tyrosine Phosphatases/genetics
Czasopismo naukowe
Tytuł :
Leptin and insulin act on POMC neurons to promote the browning of white fat.
Autorzy :
Dodd GT; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.
Decherf S; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.
Loh K; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.
Simonds SE; Department of Physiology, Monash University, Victoria 3800, Australia.
Wiede F; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.
Balland E; Department of Physiology, Monash University, Victoria 3800, Australia.
Merry TL; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.
Münzberg H; Pennington Biomedical Research Center, LSU Systems, Baton Rouge, LA 70808, USA.
Zhang ZY; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Kahn BB; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Neel BG; Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital and Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada.
Bence KK; Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Andrews ZB; Department of Physiology, Monash University, Victoria 3800, Australia.
Cowley MA; Department of Physiology, Monash University, Victoria 3800, Australia.
Tiganis T; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia. Electronic address: .
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Źródło :
Cell [Cell] 2015 Jan 15; Vol. 160 (1-2), pp. 88-104.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipose Tissue, Brown/*metabolism
Adipose Tissue, White/*metabolism
Insulin/*metabolism
Leptin/*metabolism
Pro-Opiomelanocortin/*metabolism
Adiposity ; Animals ; Body Temperature Regulation ; Mice, Inbred C57BL ; Mice, Knockout ; Neurons/metabolism ; Obesity/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/metabolism
Czasopismo naukowe
Tytuł :
The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus.
Autorzy :
Dodd GT; Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
Worth AA; Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
Nunn N; Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
Korpal AK; Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
Bechtold DA; Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
Allison MB; Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Ann Arbor, Michigan 48105, USA.
Myers MG Jr; Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Ann Arbor, Michigan 48105, USA.
Statnick MA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
Luckman SM; Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK. Electronic address: .
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Źródło :
Cell metabolism [Cell Metab] 2014 Oct 07; Vol. 20 (4), pp. 639-49. Date of Electronic Publication: 2014 Aug 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Dorsomedial Hypothalamic Nucleus/*metabolism
Leptin/*metabolism
Prolactin-Releasing Hormone/*metabolism
Alleles ; Animals ; Cholecystokinin/metabolism ; Energy Metabolism ; Mice ; Mice, Knockout ; Mice, Transgenic ; Neurons/metabolism ; Neurons/pathology ; Obesity/etiology ; Prolactin-Releasing Hormone/deficiency ; Prolactin-Releasing Hormone/genetics ; Receptors, Leptin/deficiency ; Receptors, Leptin/genetics ; Receptors, Leptin/metabolism ; Thermogenesis
Czasopismo naukowe

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