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Wyszukujesz frazę ""Dopamine Antagonists"" wg kryterium: Temat


Tytuł :
Novel Dual-Target μ-Opioid Receptor and Dopamine D 3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.
Autorzy :
Bonifazi A; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.
Battiti FO; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.
Sanchez J; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Midlands NG2 7AG, U.K.
Zaidi SA; Bridge Institute, Michelson Center for Convergent Bioscience, Department of Chemistry, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, United States.
Bow E; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892, United States.
Makarova M; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892, United States.
Cao J; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.
Shaik AB; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.
Sulima A; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892, United States.
Rice KC; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892, United States.
Katritch V; Bridge Institute, Michelson Center for Convergent Bioscience, Department of Chemistry, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, United States.
Canals M; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Midlands NG2 7AG, U.K.
Lane JR; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Midlands NG2 7AG, U.K.
Newman AH; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jun 10; Vol. 64 (11), pp. 7778-7808. Date of Electronic Publication: 2021 May 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
Ligands*
Dopamine Antagonists/*chemistry
Receptors, Dopamine D3/*metabolism
Receptors, Opioid, mu/*metabolism
Analgesics, Opioid/therapeutic use ; Animals ; Binding Sites ; Biphenyl Compounds/chemistry ; Biphenyl Compounds/metabolism ; Biphenyl Compounds/therapeutic use ; Disease Models, Animal ; Dopamine Antagonists/metabolism ; Dopamine Antagonists/therapeutic use ; Drug Design ; Fluorescence Resonance Energy Transfer ; Mice ; Molecular Docking Simulation ; Opioid-Related Disorders/drug therapy ; Pain/drug therapy ; Pain Management ; Receptors, Dopamine D3/agonists ; Receptors, Dopamine D3/antagonists & inhibitors ; Receptors, Opioid, mu/agonists ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis.
Autorzy :
Mohamad SA; Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Safwat MA; Department of Pharmaceutics, Faculty of Pharmacy, South Valley University, Qena, Egypt.
Elrehany M; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt.; Department of Biochemistry, Faculty of Medicine, Minia University, Minia, Egypt.
Maher SA; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Badawi AM; Department of Otorhinolaryngology, Faculty of Medicine, Minia University, Minia, Egypt.
Mansour HF; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 229-239.
Typ publikacji :
Journal Article
MeSH Terms :
Emulsions*
Surface-Active Agents*
Dopamine Antagonists/*administration & dosage
Histamine H1 Antagonists, Non-Sedating/*administration & dosage
Loratadine/*administration & dosage
Nasal Mucosa/*drug effects
Rhinitis, Allergic/*metabolism
Sulpiride/*administration & dosage
Administration, Intranasal ; Animals ; Calorimetry, Differential Scanning ; Disease Models, Animal ; Dopamine Antagonists/pharmacology ; Drug Combinations ; Drug Liberation ; Glycerol ; Histamine H1 Antagonists, Non-Sedating/pharmacology ; In Vitro Techniques ; Interleukin-1/metabolism ; Lecithins ; Loratadine/pharmacology ; Nanostructures ; Nasal Mucosa/metabolism ; Olive Oil ; Ovalbumin ; Paranasal Sinuses/drug effects ; Paranasal Sinuses/metabolism ; Polysorbates ; Rabbits ; Rhinitis, Allergic/chemically induced ; Sodium Cholate ; Soybeans ; Spectroscopy, Fourier Transform Infrared ; Sulpiride/pharmacology ; Transforming Growth Factor beta/drug effects ; Transforming Growth Factor beta/metabolism ; Tumor Necrosis Factor-alpha/drug effects ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
The histamine H3R and dopamine D2R/D3R antagonist ST-713 ameliorates autism-like behavioral features in BTBR T+tf/J mice by multiple actions.
Autorzy :
Venkatachalam K; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates; Zayed Center for Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates.
Eissa N; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates; Zayed Center for Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates; Department of Applied Sciences, College of Arts and Sciences, Abu Dhabi University, P.O. Box 59911, Abu Dhabi, United Arab Emirates.
Awad MA; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates; Zayed Center for Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates.
Jayaprakash P; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates; Zayed Center for Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates.
Zhong S; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225 Düsseldorf, Germany.
Stölting F; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225 Düsseldorf, Germany.
Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225 Düsseldorf, Germany.
Sadek B; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates; Zayed Center for Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jun; Vol. 138, pp. 111517. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, Histamine H3*/metabolism
Autistic Disorder/*drug therapy
Dopamine Antagonists/*therapeutic use
Dopamine D2 Receptor Antagonists/*therapeutic use
Histamine Antagonists/*therapeutic use
Receptors, Dopamine D3/*antagonists & inhibitors
Animals ; Autistic Disorder/genetics ; Autistic Disorder/metabolism ; Cerebellum/drug effects ; Cerebellum/metabolism ; Dopamine Antagonists/pharmacology ; Dopamine D2 Receptor Antagonists/pharmacology ; Dose-Response Relationship, Drug ; Hippocampus/drug effects ; Hippocampus/metabolism ; Histamine Antagonists/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/metabolism
Czasopismo naukowe
Tytuł :
Recent findings leading to the discovery of selective dopamine D 4 receptor ligands for the treatment of widespread diseases.
Autorzy :
Giorgioni G; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032, Camerino, Italy.
Del Bello F; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032, Camerino, Italy. Electronic address: .
Pavletić P; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032, Camerino, Italy.
Quaglia W; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032, Camerino, Italy. Electronic address: .
Botticelli L; School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna Delle Carceri 9, 62032, Camerino, Italy.
Cifani C; School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna Delle Carceri 9, 62032, Camerino, Italy.
Micioni Di Bonaventura E; School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna Delle Carceri 9, 62032, Camerino, Italy.
Micioni Di Bonaventura MV; School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna Delle Carceri 9, 62032, Camerino, Italy.
Piergentili A; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032, Camerino, Italy.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 15; Vol. 212, pp. 113141. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Discovery*
Dopamine Antagonists/*pharmacology
Neoplasms/*drug therapy
Receptors, Dopamine D4/*antagonists & inhibitors
Alcohol-Related Disorders/drug therapy ; Animals ; Cognitive Dysfunction/drug therapy ; Dopamine Antagonists/chemical synthesis ; Dopamine Antagonists/chemistry ; Humans ; Ligands ; Parkinson Disease/drug therapy ; Substance-Related Disorders/drug therapy
Czasopismo naukowe
Tytuł :
Quantitative analysis of fluorescent ligand binding to dopamine D 3 receptors using live-cell microscopy.
Autorzy :
Allikalt A; Institute of Chemistry, University of Tartu, Estonia.; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nürnberg, Germany.
Laasfeld T; Institute of Chemistry, University of Tartu, Estonia.
Ilisson M; Institute of Chemistry, University of Tartu, Estonia.
Kopanchuk S; Institute of Chemistry, University of Tartu, Estonia.
Rinken A; Institute of Chemistry, University of Tartu, Estonia.
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Źródło :
The FEBS journal [FEBS J] 2021 Mar; Vol. 288 (5), pp. 1514-1532. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Assay*
Software*
Carbocyanines/*chemistry
Dopamine Antagonists/*pharmacology
Receptors, Dopamine/*metabolism
Spiperone/*analogs & derivatives
Dopamine/metabolism ; Dopamine/pharmacology ; Dopamine Antagonists/chemical synthesis ; HEK293 Cells ; Humans ; Image Processing, Computer-Assisted/methods ; Image Processing, Computer-Assisted/statistics & numerical data ; Kinetics ; Ligands ; Machine Learning ; Microscopy, Fluorescence/methods ; Microscopy, Fluorescence/statistics & numerical data ; Protein Binding ; Spiperone/chemistry
Czasopismo naukowe
Tytuł :
Pharmacology profile of F17464, a dopamine D 3 receptor preferential antagonist.
Autorzy :
Cosi C; Innovation Unit CNS, CEPC Pierre Fabre Laboratories, Bel Air de Campans, 81106, Castres, France.
Martel JC; Innovation Unit CNS, CEPC Pierre Fabre Laboratories, Bel Air de Campans, 81106, Castres, France.
Auclair AL; Innovation Unit CNS, CEPC Pierre Fabre Laboratories, Bel Air de Campans, 81106, Castres, France.
Collo G; Dept of Molecular and Translational Medicine University of Brescia, Viale Europa 11, Brescia, Italy.
Cavalleri L; Dept of Molecular and Translational Medicine University of Brescia, Viale Europa 11, Brescia, Italy.
Heusler P; Innovation Unit CNS, CEPC Pierre Fabre Laboratories, Bel Air de Campans, 81106, Castres, France.
Leriche L; Innovation Unit CNS, CEPC Pierre Fabre Laboratories, Bel Air de Campans, 81106, Castres, France.
Gaudoux F; Innovation Unit CNS, CEPC Pierre Fabre Laboratories, Bel Air de Campans, 81106, Castres, France.
Sokoloff P; Innovation Unit CNS, CEPC Pierre Fabre Laboratories, Bel Air de Campans, 81106, Castres, France.
Moser PC; Innovation Unit CNS, CEPC Pierre Fabre Laboratories, Bel Air de Campans, 81106, Castres, France.
Gatti-McArthur S; Innovation Unit CNS, CEPC Pierre Fabre Laboratories, Bel Air de Campans, 81106, Castres, France. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Jan 05; Vol. 890, pp. 173635. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Antipsychotic Agents/*pharmacology
Benzopyrans/*pharmacology
Dopamine Antagonists/*pharmacology
Piperazines/*pharmacology
Receptors, Dopamine D3/*antagonists & inhibitors
Sulfonamides/*pharmacology
Animals ; Antipsychotic Agents/therapeutic use ; Autistic Disorder/chemically induced ; Autistic Disorder/drug therapy ; Behavior, Animal/drug effects ; Benzopyrans/therapeutic use ; Biogenic Monoamines/metabolism ; Brain/drug effects ; Brain/metabolism ; Catalepsy/drug therapy ; Cells, Cultured ; Dopamine/metabolism ; Dopamine Antagonists/therapeutic use ; Dopaminergic Neurons/drug effects ; Female ; Genes, fos/drug effects ; Male ; Mice ; Neuronal Plasticity/drug effects ; Piperazines/therapeutic use ; Prolactin/blood ; Rats, Sprague-Dawley ; Receptors, Dopamine D3/metabolism ; Sulfonamides/therapeutic use ; Valproic Acid/toxicity
Czasopismo naukowe
Tytuł :
Intravenous Amisulpride Does Not Meaningfully Prolong the QTc Interval at Doses Effective for the Management of Postoperative Nausea and Vomiting.
Autorzy :
Fox GM; From the Department of Clinical Development, Acacia Pharma Ltd, Cambridge, United Kingdom.
Albayaty M; Early Phase Clinical Unit, PAREXEL International, London, United Kingdom.
Walker JL; From the Department of Clinical Development, Acacia Pharma Ltd, Cambridge, United Kingdom.
Xue H; eResearch Technologies Inc, Rochester, New York.
Darpo B; eResearch Technologies Inc, Rochester, New York.
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Źródło :
Anesthesia and analgesia [Anesth Analg] 2021 Jan; Vol. 132 (1), pp. 150-159.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Management*
Amisulpride/*administration & dosage
Dopamine Antagonists/*administration & dosage
Heart Rate/*drug effects
Long QT Syndrome/*chemically induced
Postoperative Nausea and Vomiting/*prevention & control
Administration, Intravenous ; Adolescent ; Adult ; Aged ; Amisulpride/adverse effects ; Cross-Over Studies ; Dopamine Antagonists/adverse effects ; Dose-Response Relationship, Drug ; Double-Blind Method ; Electrocardiography/drug effects ; Female ; Heart Rate/physiology ; Humans ; Long QT Syndrome/diagnosis ; Male ; Middle Aged ; Postoperative Nausea and Vomiting/diagnosis ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Neural bases for attenuation of morphine withdrawal by Heantos-4: role of l-tetrahydropalmatine.
Autorzy :
Ahn S; Department of Psychiatry, University of British Columbia, Vancouver, V6T 2A1, Canada.
Nesbit MO; Department of Psychiatry, University of British Columbia, Vancouver, V6T 2A1, Canada.
Zou H; Department of Psychiatry, University of British Columbia, Vancouver, V6T 2A1, Canada.
Vacca G; Department of Psychiatry, University of British Columbia, Vancouver, V6T 2A1, Canada.
Axerio-Cilies P; Department of Psychiatry, University of British Columbia, Vancouver, V6T 2A1, Canada.
Van Sung T; Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.
Phillips AG; Department of Psychiatry, University of British Columbia, Vancouver, V6T 2A1, Canada. .
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Źródło :
Scientific reports [Sci Rep] 2020 Dec 04; Vol. 10 (1), pp. 21275. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Berberine Alkaloids/*therapeutic use
Dopamine Antagonists/*therapeutic use
Nucleus Accumbens/*drug effects
Plant Extracts/*therapeutic use
Substance Withdrawal Syndrome/*drug therapy
Analgesics, Opioid/adverse effects ; Animals ; Berberine Alkaloids/metabolism ; Berberine Alkaloids/pharmacology ; Dopamine/metabolism ; Dopamine Antagonists/metabolism ; Dopamine Antagonists/pharmacology ; Drug Evaluation, Preclinical ; Male ; Morphine/adverse effects ; Nucleus Accumbens/metabolism ; Phytotherapy ; Plant Extracts/metabolism ; Plant Extracts/pharmacology ; Quinpirole ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Efficacy and Safety of Dasotraline in Adults With Binge-Eating Disorder: A Randomized, Placebo-Controlled, Flexible-Dose Clinical Trial.
Autorzy :
McElroy SL; Lindner Center of HOPE, Mason, Ohio, USA.; Biological Psychiatry Program, University of Cincinnati Medical College, Cincinnati, Ohio, USA.
Hudson JI; Biological Psychiatry Laboratory, McLean Hospital, Belmont, Massachusetts; and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Grilo CM; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
Guerdjikova AI; Lindner Center of HOPE, Mason, Ohio, USA.; Biological Psychiatry Program, University of Cincinnati Medical College, Cincinnati, Ohio, USA.
Deng L; Sunovion Pharmaceuticals Inc., Marlborough, Massachusetts, USA.
Koblan KS; Sunovion Pharmaceuticals Inc., Marlborough, Massachusetts, USA.
Goldman R; Sunovion Pharmaceuticals Inc., Marlborough, Massachusetts, USA.
Navia B; Sunovion Pharmaceuticals Inc., 84 Waterford Dr, Marlborough, MA 01752. .; Sunovion Pharmaceuticals Inc., Marlborough, Massachusetts, USA.
Hopkins S; Sunovion Pharmaceuticals Inc., Marlborough, Massachusetts, USA.
Loebel A; Sunovion Pharmaceuticals Inc., Marlborough, Massachusetts, USA.
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Źródło :
The Journal of clinical psychiatry [J Clin Psychiatry] 2020 Sep 08; Vol. 81 (5). Date of Electronic Publication: 2020 Sep 08.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
1-Naphthylamine/*analogs & derivatives
Binge-Eating Disorder/*drug therapy
Dopamine Antagonists/*therapeutic use
1-Naphthylamine/administration & dosage ; 1-Naphthylamine/adverse effects ; 1-Naphthylamine/therapeutic use ; Adult ; Dopamine Antagonists/administration & dosage ; Dopamine Antagonists/adverse effects ; Double-Blind Method ; Female ; Humans ; Male ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Synthesis and dopamine receptor pharmacological evaluations on ring C ortho halogenated 1-phenylbenzazepines.
Autorzy :
Giri R; Department of Chemistry, Hunter College, City University of New York, 695 Park Avenue, NY 10065, USA; Program in Chemistry, CUNY Graduate Center, 365 5(th) Avenue, New York, NY 10016, USA.
Namballa HK; Department of Chemistry, Hunter College, City University of New York, 695 Park Avenue, NY 10065, USA.
Sarker A; Department of Chemistry, Hunter College, City University of New York, 695 Park Avenue, NY 10065, USA.
Alberts I; LaGuardia Community College, Department of Chemistry, 31-10 Thompson Avenue, LIC, NY 11104, USA.
Harding WW; Department of Chemistry, Hunter College, City University of New York, 695 Park Avenue, NY 10065, USA; Program in Chemistry, CUNY Graduate Center, 365 5(th) Avenue, New York, NY 10016, USA; Program in Biochemistry, CUNY Graduate Center, 365 5(th) Avenue, New York, NY 10016, USA. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Aug 15; Vol. 30 (16), pp. 127305. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzazepines/*pharmacology
Dopamine Antagonists/*pharmacology
Receptors, Dopamine D1/*agonists
Benzazepines/chemical synthesis ; Benzazepines/chemistry ; Dopamine Antagonists/chemical synthesis ; Dopamine Antagonists/chemistry ; Dose-Response Relationship, Drug ; Halogenation ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Adding perphenazine to increase effectiveness of standard glioblastoma chemoirradiation.
Autorzy :
Kast RE; IIAIGC Study Center, Burlington, Vermont, USA.
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Źródło :
Journal of B.U.ON. : official journal of the Balkan Union of Oncology [J BUON] 2020 Jul-Aug; Vol. 25 (4), pp. 1676-1686.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Dopamine Antagonists/*therapeutic use
Glioblastoma/*drug therapy
Glioblastoma/*radiotherapy
Perphenazine/*therapeutic use
Dopamine Antagonists/pharmacology ; Glioblastoma/physiopathology ; Humans ; Perphenazine/pharmacology
Czasopismo naukowe
Tytuł :
Dopamine D 1 or D 3 receptor modulators prevent morphine tolerance and reduce opioid withdrawal symptoms.
Autorzy :
Rodgers HM; Department of Emergency Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
Lim SA; Department of Emergency Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
Yow J; Department of Emergency Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
Dinkins ML; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
Patton R; Department of Emergency Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
Clemens S; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
Brewer KL; Department of Emergency Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America. Electronic address: .
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Źródło :
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2020 Jul; Vol. 194, pp. 172935. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopamine Agonists/*pharmacology
Dopamine Antagonists/*pharmacology
Morphine/*pharmacology
Receptors, Dopamine D1/*antagonists & inhibitors
Receptors, Dopamine D3/*agonists
Substance Withdrawal Syndrome/*drug therapy
Analgesia/methods ; Analgesics, Opioid/pharmacology ; Animals ; Chronic Pain/drug therapy ; Chronic Pain/metabolism ; Dopamine Agonists/administration & dosage ; Dopamine Antagonists/administration & dosage ; Drug Combinations ; Drug Tolerance ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Morphine/administration & dosage ; Neuralgia/drug therapy ; Neuralgia/metabolism ; Pramipexole/pharmacology ; Rats ; Rats, Long-Evans ; Receptors, Dopamine D1/administration & dosage ; Receptors, Dopamine D3/administration & dosage ; Substance Withdrawal Syndrome/metabolism
Czasopismo naukowe
Tytuł :
Dopamine antagonist antipsychotics in diverted forensic populations.
Autorzy :
Cummings MA; Department of Psychiatry, University of California, Riverside, CA, USA.; Department of Psychiatry, University of California, Irvine, Patton, CA92369, USA.
Proctor GJ; Department of Psychiatry, Loma Linda University School of Medicine, Patton, CA92369, USA.
Arias AW; Department of Psychiatry, University of California, Irvine, Patton, CA92369, USA.
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Źródło :
CNS spectrums [CNS Spectr] 2020 Apr; Vol. 25 (2), pp. 128-135. Date of Electronic Publication: 2019 May 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Medication Adherence*
Antipsychotic Agents/*therapeutic use
Dopamine Antagonists/*therapeutic use
Forensic Psychiatry/*methods
Schizophrenia/*drug therapy
Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/blood ; Dopamine Antagonists/administration & dosage ; Dopamine Antagonists/blood ; Humans ; Schizophrenia/epidemiology ; Schizophrenic Psychology
Czasopismo naukowe
Tytuł :
Antidopaminergic treatment is associated with reduced chorea and irritability but impaired cognition in Huntington's disease (Enroll-HD).
Autorzy :
Harris KL; Department of Clinical Neurosciences, The University of Cambridge, Cambridge, United Kingdom .
Kuan WL; Department of Clinical Neurosciences, The University of Cambridge, Cambridge, United Kingdom.
Mason SL; Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, Cambridge, Cambridgeshire, United Kingdom.
Barker RA; Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, and MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2020 Jun; Vol. 91 (6), pp. 622-630. Date of Electronic Publication: 2020 Mar 30.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Chorea/*drug therapy
Cognition/*drug effects
Cognition Disorders/*chemically induced
Dopamine Antagonists/*therapeutic use
Huntington Disease/*drug therapy
Irritable Mood/*drug effects
Adult ; Aged ; Databases, Factual ; Dopamine Antagonists/administration & dosage ; Dopamine Antagonists/adverse effects ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.
Autorzy :
Tan L; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Pudong New District, Shanghai 201210, China.
Zhou Q; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Pudong New District, Shanghai 201210, China.
Yan W; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Pudong New District, Shanghai 201210, China.
Sun J; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Pudong New District, Shanghai 201210, China.
Kozikowski AP; StarWise Therapeutics LLC, 2020 North Lincoln Park West, Chicago Illinois 60614, United States.
Zhao S; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Pudong New District, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong New District, Shanghai 201210, China.
Huang XP; Department of Pharmacology, National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), University of North Carolina Chapel Hill Medical School, Chapel Hill, North Carolina 27599, United States.
Cheng J; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Pudong New District, Shanghai 201210, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 May 14; Vol. 63 (9), pp. 4579-4602. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cyclopropanes/*pharmacokinetics
Dopamine Agonists/*pharmacokinetics
Dopamine Antagonists/*pharmacokinetics
Methylamines/*pharmacokinetics
Receptors, Dopamine D3/*metabolism
Animals ; Binding Sites ; Brain/metabolism ; Cyclopropanes/chemical synthesis ; Cyclopropanes/metabolism ; Dopamine Agonists/chemical synthesis ; Dopamine Agonists/metabolism ; Dopamine Antagonists/chemical synthesis ; Dopamine Antagonists/metabolism ; Drug Design ; Ligands ; Methylamines/chemical synthesis ; Methylamines/metabolism ; Mice, Inbred ICR ; Molecular Docking Simulation ; Molecular Structure ; Receptor, Serotonin, 5-HT2C/metabolism ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
An overview of intravenous amisulpride as a new therapeutic option for the prophylaxis and treatment of postoperative nausea and vomiting.
Autorzy :
Smyla N; Department of Anaesthesiology and Intensive Care Medicine, Philipps-University Marburg, Marburg, Germany.
Koch T; Department of Anaesthesiology and Intensive Care Medicine, Philipps-University Marburg, Marburg, Germany.
Eberhart LH; Department of Anaesthesiology and Intensive Care Medicine, Philipps-University Marburg, Marburg, Germany.
Gehling M; Department of Anaesthesiology and Intensive Care Medicine, Philipps-University Marburg, Marburg, Germany.; Centre for Pain Management, Kassel, Germany.
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Źródło :
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2020 Apr; Vol. 21 (5), pp. 517-522. Date of Electronic Publication: 2020 Jan 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Amisulpride/*therapeutic use
Antiemetics/*therapeutic use
Dopamine Antagonists/*therapeutic use
Postoperative Nausea and Vomiting/*drug therapy
Administration, Intravenous ; Amisulpride/administration & dosage ; Amisulpride/adverse effects ; Antiemetics/administration & dosage ; Antiemetics/adverse effects ; Cost-Benefit Analysis ; Dopamine Antagonists/administration & dosage ; Dopamine Antagonists/adverse effects ; Droperidol/administration & dosage ; Droperidol/adverse effects ; Droperidol/therapeutic use ; Drug Labeling ; Humans ; Postoperative Nausea and Vomiting/prevention & control ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł :
Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium‐dependent, non‐D2 receptor‐dependent, manner.
Autorzy :
Weissenrieder, Jillian S. (AUTHOR)
Reed, Jessie L. (AUTHOR)
Moldovan, George‐Lucian (AUTHOR)
Johnson, Martin T. (AUTHOR)
Trebak, Mohamed (AUTHOR)
Neighbors, Jeffrey D. (AUTHOR)
Mailman, Richard B. (AUTHOR)
Hohl, Raymond J. (AUTHOR)
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Źródło :
Pharmacology Research & Perspectives. May2021, Vol. 9 Issue 3, p1-12. 12p.
Czasopismo naukowe
Tytuł :
The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.
Autorzy :
Bhat K; Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Saki M; Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Vlashi E; Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
Cheng F; Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Duhachek-Muggy S; Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Alli C; Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Yu G; Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Medina P; Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
He L; Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Damoiseaux R; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.; Molecular Screening Shared Resource, University of California, Los Angeles, CA 90095.
Pellegrini M; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Zemke NR; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095.
Nghiemphu PL; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.; Department of Neurology, University of California, Los Angeles, CA 90095.
Cloughesy TF; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.; Department of Neurology, University of California, Los Angeles, CA 90095.
Liau LM; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.; Department of Neurosurgery, University of California, Los Angeles, CA 90095.
Kornblum HI; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.; Neuropsychiatric Institute-Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA 90095.
Pajonk F; Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; .; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 May 19; Vol. 117 (20), pp. 11085-11096. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Phenotype*
Dopamine Antagonists/*pharmacology
Glioblastoma/*metabolism
Receptors, Dopamine/*drug effects
Trifluoperazine/*pharmacology
Animals ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Brain Neoplasms/radiotherapy ; Disease Models, Animal ; Dopamine Antagonists/therapeutic use ; Gene Expression Regulation, Neoplastic ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Glioblastoma/radiotherapy ; Glioma/drug therapy ; Glioma/metabolism ; Glioma/pathology ; Glioma/radiotherapy ; Glycogen Synthase Kinase 3/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, SCID ; RNA, Messenger/metabolism ; Radiation Tolerance ; SOXB1 Transcription Factors ; Trifluoperazine/therapeutic use ; Xenograft Model Antitumor Assays ; beta Catenin
Czasopismo naukowe
Tytuł :
Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis.
Autorzy :
Heo MJ; Korea Institute of Dermatological Science, GeneCellPharm Corporation, 375 Munjeong 2(i)-dong, Songpa-gu, Seoul 05836, Korea.
Choi SY; Korea Institute of Dermatological Science, GeneCellPharm Corporation, 375 Munjeong 2(i)-dong, Songpa-gu, Seoul 05836, Korea.
Lee C; Korea Institute of Dermatological Science, GeneCellPharm Corporation, 375 Munjeong 2(i)-dong, Songpa-gu, Seoul 05836, Korea.
Choi YM; Korea Institute of Dermatological Science, GeneCellPharm Corporation, 375 Munjeong 2(i)-dong, Songpa-gu, Seoul 05836, Korea.
An IS; Korea Institute of Dermatological Science, GeneCellPharm Corporation, 375 Munjeong 2(i)-dong, Songpa-gu, Seoul 05836, Korea.
Bae S; Research Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk University, Seoul 05029, Korea.
An S; Research Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk University, Seoul 05029, Korea.
Jung JH; Korea Institute of Dermatological Science, GeneCellPharm Corporation, 375 Munjeong 2(i)-dong, Songpa-gu, Seoul 05836, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 May 03; Vol. 21 (9). Date of Electronic Publication: 2020 May 03.
Typ publikacji :
Journal Article
MeSH Terms :
Dermatitis, Allergic Contact/*drug therapy
Dopamine Antagonists/*therapeutic use
Perphenazine/*therapeutic use
Animals ; Cytokines/metabolism ; Dermatitis, Allergic Contact/etiology ; Dopamine Antagonists/pharmacology ; Immunoglobulin G/metabolism ; Mast Cells/drug effects ; Mast Cells/immunology ; Mice ; Mice, Inbred C57BL ; NIH 3T3 Cells ; Oxazolone/toxicity ; Perphenazine/pharmacology ; Tetradecanoylphorbol Acetate/toxicity ; Th2 Cells/drug effects ; Th2 Cells/immunology
Czasopismo naukowe
Tytuł :
Acute Dystonic Reactions in Children Treated for Headache With Prochlorperazine or Metoclopramide.
Autorzy :
Kirkpatrick L; Division of Child Neurology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: .
Sogawa Y; Division of Child Neurology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Cleves C; Division of Child Neurology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
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Źródło :
Pediatric neurology [Pediatr Neurol] 2020 May; Vol. 106, pp. 63-64. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Drug-Related Side Effects and Adverse Reactions*/epidemiology
Dopamine Antagonists/*adverse effects
Dystonia/*chemically induced
Headache Disorders, Primary/*drug therapy
Metoclopramide/*adverse effects
Prochlorperazine/*adverse effects
Adolescent ; Child ; Dopamine Antagonists/administration & dosage ; Female ; Hospitals, Pediatric/statistics & numerical data ; Humans ; Male ; Metoclopramide/administration & dosage ; Prochlorperazine/administration & dosage ; Retrospective Studies ; Tertiary Care Centers/statistics & numerical data
Czasopismo naukowe

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