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Tytuł :
Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain.
Autorzy :
Knabbe J; Department of General Psychiatry, Heidelberg University Hospital, 69120 Heidelberg, Germany.; Functional Neuroanatomy, Heidelberg University, 69120 Heidelberg, Germany.
Protzmann J; Functional Neuroanatomy, Heidelberg University, 69120 Heidelberg, Germany.; Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden.
Schneider N; Functional Neuroanatomy, Heidelberg University, 69120 Heidelberg, Germany.; Department of Neurology, University Hospital Zurich, 8044 Zurich, Switzerland.
Berger M; Institute for Zoology, University of Cologne, 50674 Cologne, Germany.
Dannehl D; Institute of Neuroanatomy, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Wei S; Behavioral Genetics Research Group, Institute of Psychopharmacology, Central Institute of Mental Health, Heidelberg University, 68159 Mannheim, Germany.
Strahle C; Functional Neuroanatomy, Heidelberg University, 69120 Heidelberg, Germany.
Tegtmeier M; Institute for Zoology, University of Cologne, 50674 Cologne, Germany.
Jaiswal A; Biomedical Computer Vision Group, BioQuant, IPMB, Heidelberg University, Heidelberg, 69120 Germany.
Zheng H; Functional Neuroanatomy, Heidelberg University, 69120 Heidelberg, Germany.
Krüger M; CECAD Research Center, University of Cologne, 50931 Cologne, Germany.
Rohr K; Biomedical Computer Vision Group, BioQuant, IPMB, Heidelberg University, Heidelberg, 69120 Germany.
Spanagel R; Institute of Psychopharmacology, Central Institute of Mental Health, Heidelberg University, 68159 Mannheim, Germany.
Bilbao A; Behavioral Genetics Research Group, Institute of Psychopharmacology, Central Institute of Mental Health, Heidelberg University, 68159 Mannheim, Germany.
Engelhardt M; Institute of Neuroanatomy, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.; Institute of Anatomy and Cell Biology, Johannes Kepler University, 4020 Linz, Austria.
Scholz H; Institute for Zoology, University of Cologne, 50674 Cologne, Germany.
Cambridge SB; Anatomy II, Heinrich-Heine University, 40225 Düsseldorf, Germany.; Current address: Dr. Senckenbergische Anatomie, Goethe University, 60590 Frankfurt, Germany.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jun 21; Vol. 119 (25), pp. e2122477119. Date of Electronic Publication: 2022 Jun 14.
Typ publikacji :
Journal Article
MeSH Terms :
Alcoholic Intoxication*/metabolism
Alcoholic Intoxication*/pathology
Dopaminergic Neurons*/drug effects
Dopaminergic Neurons*/metabolism
Ethanol*/administration & dosage
Ethanol*/toxicity
Hippocampus*/drug effects
Hippocampus*/metabolism
Nerve Tissue Proteins*/genetics
Nerve Tissue Proteins*/metabolism
Animals ; Behavior, Addictive/chemically induced ; Dose-Response Relationship, Drug ; Drosophila melanogaster ; Gene Knockdown Techniques ; Mice ; Mitochondria/metabolism ; Protein Transport/drug effects
Czasopismo naukowe
Tytuł :
Reduced dopaminergic neuron degeneration and global transcriptional changes in Parkinson's disease mouse brains engrafted with human neural stems during the early disease stage.
Autorzy :
Pereira MCL; Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Boese AC; Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Murad R; Bioinformatics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Yin J; Bioinformatics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Hamblin MH; Tulane University Health Sciences Center, Tulane University, New Orleans, LA 70112, USA.
Lee JP; Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA. Electronic address: .
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Źródło :
Experimental neurology [Exp Neurol] 2022 Jun; Vol. 352, pp. 114042. Date of Electronic Publication: 2022 Mar 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopaminergic Neurons*
Parkinson Disease*/drug therapy
Parkinson Disease*/therapy
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology ; Animals ; Brain/metabolism ; Disease Models, Animal ; Dopamine/metabolism ; Humans ; Mice ; Mice, Inbred C57BL ; Nerve Degeneration/pathology ; Substantia Nigra/metabolism
Czasopismo naukowe
Tytuł :
Dopaminergic neuronal death in the substantia nigra associates with change in serum levels of TNF-α and IL-1β; evidence from early experimental model of Parkinson's disease.
Autorzy :
Piri H; Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.
Sharifi S; Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.
Nigjeh S; Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.
Haghdoost-Yazdi H; Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.
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Źródło :
Neurological research [Neurol Res] 2022 Jun; Vol. 44 (6), pp. 544-553. Date of Electronic Publication: 2022 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Dopaminergic Neurons*/cytology
Dopaminergic Neurons*/pathology
Interleukin-1beta*/blood
Parkinson Disease*/drug therapy
Tumor Necrosis Factor-alpha*/blood
Animals ; Cytokines/metabolism ; Disease Models, Animal ; Dopamine ; Oxidopamine/toxicity ; Rats ; Substantia Nigra/pathology
Czasopismo naukowe
Tytuł :
Discovery of new ERRγ agonists regulating dopaminergic neuronal phenotype in SH-SY5Y cells.
Autorzy :
Kim T; College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon-si, Gyeonggi-do 11160, Republic of Korea.
Kim HI; College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon-si, Gyeonggi-do 11160, Republic of Korea.
Oh H; College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon-si, Gyeonggi-do 11160, Republic of Korea.
Jeon Y; College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon-si, Gyeonggi-do 11160, Republic of Korea.
Shin H; College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon-si, Gyeonggi-do 11160, Republic of Korea.
Kim HS; College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon-si, Gyeonggi-do 11160, Republic of Korea.
Lim J; College of Pharmacy, Woosuk University, Wanju-gun 55338, Republic of Korea.
Lim C; School of Pharmacy, Jeonbuk National University, Jeonju 54896, Republic of Korea.
Yoo J; D5 Therapeutics, A703, Hyundai-JisikSanEop Center, 3 Godeung-ro, Sujeong-gu, Seongnam-si, Gyeonggi-do 13105, Republic of Korea.
Suh YG; College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon-si, Gyeonggi-do 11160, Republic of Korea.
Son WS; College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon-si, Gyeonggi-do 11160, Republic of Korea.
Choi HJ; College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon-si, Gyeonggi-do 11160, Republic of Korea. Electronic address: .
Kim SH; College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon-si, Gyeonggi-do 11160, Republic of Korea. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2022 May; Vol. 122, pp. 105716. Date of Electronic Publication: 2022 Mar 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopaminergic Neurons*/metabolism
Receptors, Estrogen*/metabolism
Molecular Docking Simulation ; Phenotype ; Up-Regulation
Czasopismo naukowe
Tytuł :
Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction.
Autorzy :
Liu Z; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Yang N; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Dong J; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Clinical Research Center on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, 116011, Dalian, Liaoning, China.
Tian W; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 20025, Shanghai, China.
Chang L; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Ma J; Department of Neurology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China.
Guo J; Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Tan J; Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, 410008, Changsha, Hunan, China.
Dong A; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, 100871, Beijing, China.; PKU-IDG/McGovern Institute for Brain Research, 100871, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, 100871, Beijing, China.
He K; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, 100871, Beijing, China.; PKU-IDG/McGovern Institute for Brain Research, 100871, Beijing, China.
Zhou J; In Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Cinar R; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA.
Wu J; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Salinas AG; Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, 20852, USA.
Sun L; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Kumar M; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Sullivan BT; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Oldham BB; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Pitz V; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Makarious MB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Ding J; Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Kung J; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Xie C; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Hawes SL; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Wang L; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Wang T; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, Hubei, China.
Chan P; Department of Neurology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China.
Zhang Z; Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, 410008, Changsha, Hunan, China.; Department of Neurosciences, University of South China Medical School, 421200, Hengyang, Hunan, China.
Le W; Clinical Research Center on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, 116011, Dalian, Liaoning, China.; Institute of Neurology, Sichuan Academy of Medical Sciences-Sichuan Provincial Hospital, Medical School of University of Electronics & Technology of China, 610045, Chengdu, Sichuan, China.
Chen S; Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 20025, Shanghai, China.
Lovinger DM; Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, 20852, USA.
Blauwendraat C; Integrative Neurogenomics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, 20892, USA.
Cui G; In Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Li Y; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, 100871, Beijing, China.; PKU-IDG/McGovern Institute for Brain Research, 100871, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, 100871, Beijing, China.; Chinese Institute for Brain Research, 102206, Beijing, China.
Cai H; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA. .
Tang B; Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China. .; Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, 410008, Changsha, Hunan, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China. .; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, 410008, Changsha, Hunan, China. .
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Źródło :
Nature communications [Nat Commun] 2022 Jun 17; Vol. 13 (1), pp. 3490. Date of Electronic Publication: 2022 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Dopaminergic Neurons*/metabolism
Parkinsonian Disorders*/metabolism
Lipoprotein Lipase/*metabolism
Animals ; Dopamine/metabolism ; Endocannabinoids/metabolism ; Mice ; Substantia Nigra/metabolism
Czasopismo naukowe
Tytuł :
Prenatal hypoxia alters the early ontogeny of dopamine neurons.
Autorzy :
Brandon A; Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.
Cui X; Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia.
Luan W; Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.
Ali AA; Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.
Pertile RAN; Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.
Alexander SA; Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia.
Eyles DW; Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia. .; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia. .
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Źródło :
Translational psychiatry [Transl Psychiatry] 2022 Jun 07; Vol. 12 (1), pp. 238. Date of Electronic Publication: 2022 Jun 07.
Typ publikacji :
Journal Article
MeSH Terms :
Dopaminergic Neurons*/metabolism
Mesencephalon*/metabolism
Animals ; Dopamine/metabolism ; Female ; Humans ; Hypoxia/metabolism ; Mice ; Pregnancy ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
A fast motivated tail in the ventral tegmental area.
Autorzy :
Chee MJ; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
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Źródło :
The Journal of physiology [J Physiol] 2022 Jun; Vol. 600 (11), pp. 2547-2548. Date of Electronic Publication: 2022 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Dopaminergic Neurons*
Ventral Tegmental Area*
GABAergic Neurons ; Motivation ; Reward
Czasopismo naukowe
Tytuł :
Early Life Social Stress Causes Sex- and Region-Dependent Dopaminergic Changes that Are Prevented by Minocycline.
Autorzy :
Catale C; Division of Experimental Neuroscience, Neurobiology of Behavior Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Lo Iacono L; Department of Dynamic and Clinical Psychology, and Health Studies, Sapienza University of Rome, Via degli Apuli 1, Rome, Italy.
Martini A; Division of Experimental Neuroscience, Experimental Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Heil C; Division of Experimental Neuroscience, Epigenetics and Signal Transduction Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Guatteo E; Division of Experimental Neuroscience, Experimental Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Motor Science and Wellness, University of Naples Parthenope, Naples, Italy.
Mercuri NB; Division of Experimental Neuroscience, Experimental Neurology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Systems Medicine, Università Degli Studi Di Roma Tor Vergata, Rome, Italy.
Viscomi MT; Department of Life Science and Public Health, Section of Histology and Embryology, Università Cattolica Del S. Cuore, Rome, Italy.; IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.
Palacios D; Division of Experimental Neuroscience, Epigenetics and Signal Transduction Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.; IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.; Department of Life Science and Public Health, Section of Biology, Università Cattolica Del S. Cuore, Rome, Italy.
Carola V; Division of Experimental Neuroscience, Neurobiology of Behavior Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy. .; Department of Dynamic and Clinical Psychology, and Health Studies, Sapienza University of Rome, Via degli Apuli 1, Rome, Italy. .
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Źródło :
Molecular neurobiology [Mol Neurobiol] 2022 Jun; Vol. 59 (6), pp. 3913-3932. Date of Electronic Publication: 2022 Apr 18.
Typ publikacji :
Journal Article
MeSH Terms :
Dopaminergic Neurons*/metabolism
Minocycline*/pharmacology
Stress, Psychological*
Age Factors ; Animals ; Female ; Male ; Mice ; Sex Factors ; Substantia Nigra/pathology ; Tyrosine 3-Monooxygenase/metabolism ; Ventral Tegmental Area/metabolism
Czasopismo naukowe
Tytuł :
The activity of ventral tegmental area dopamine neurons during shock omission predicts safety learning.
Autorzy :
Yau JO; School of Psychology.
McNally GP; School of Psychology.
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Źródło :
Behavioral neuroscience [Behav Neurosci] 2022 Jun; Vol. 136 (3), pp. 276-284. Date of Electronic Publication: 2022 Mar 31.
Typ publikacji :
Journal Article
MeSH Terms :
Dopaminergic Neurons*/physiology
Ventral Tegmental Area*/physiology
Animals ; Calcium ; Conditioning, Operant ; Dopamine ; Rats ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice.
Autorzy :
Rocha SM; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, United States of America; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States of America.
Bantle CM; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States of America.
Aboellail T; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, United States of America.
Chatterjee D; Jefferson Comprehensive Parkinson's Center, Vickie & Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, United States of America.
Smeyne RJ; Jefferson Comprehensive Parkinson's Center, Vickie & Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, United States of America.
Tjalkens RB; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States of America. Electronic address: .
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Źródło :
Neurobiology of disease [Neurobiol Dis] 2022 Jun 01; Vol. 167, pp. 105685. Date of Electronic Publication: 2022 Mar 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Dopaminergic Neurons*/metabolism
Rotenone*/toxicity
Animals ; Mice ; Mice, Inbred C57BL ; Microglia/metabolism ; Protein Aggregates ; Rats ; Substantia Nigra/metabolism ; alpha-Synuclein/metabolism
Czasopismo naukowe
Tytuł :
A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.
Autorzy :
Elizarova S; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany.; Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, University of Göttingen, 37077 Göttingen, Germany.; Synapse Biology Group, Department of Molecular Physiology and Cell Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany.
Chouaib AA; Department of Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, Saarland University, 66421 Homburg, Germany.
Shaib A; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany.; Institute for Neuro- and Sensory Physiology, University Medical Center, 37073 Göttingen, Germany.
Hill B; Physical Chemistry II, Faculty of Science, Ruhr University, 44801 Bochum, Germany.
Mann F; Institute of Physical Chemistry, University of Göttingen, 37077 Göttingen, Germany.
Brose N; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany.
Kruss S; Physical Chemistry II, Faculty of Science, Ruhr University, 44801 Bochum, Germany.; Institute of Physical Chemistry, University of Göttingen, 37077 Göttingen, Germany.; Biomedical Nanosensors, Fraunhofer Institute of Microelectronic Circuits and Systems, 47057 Duisburg, Germany.
Daniel JA; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 May 31; Vol. 119 (22), pp. e2202842119. Date of Electronic Publication: 2022 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Axons*/metabolism
Dopamine*/analysis
Dopamine*/metabolism
Dopaminergic Neurons*/metabolism
Nanostructures*
Neurotransmitter Agents*/analysis
Neurotransmitter Agents*/metabolism
Optical Imaging*/methods
Animals ; Brain/metabolism ; Fluorescent Dyes/chemistry ; Mice ; Paint ; Spectroscopy, Near-Infrared/methods
Czasopismo naukowe
Tytuł :
Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2.
Autorzy :
Nguyen MK; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
McAvoy K; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA.
Liao SC; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Nutritional Sciences & Toxicology, University of California Berkeley, Berkeley, CA 94720, USA.; Endocrinology Graduate Program, University of California Berkeley, Berkeley, CA 94720, USA.
Doric Z; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.; Graduate Program in Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA.
Lo I; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
Li H; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
Manfredi G; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA.
Nakamura K; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.; Graduate Program in Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA.; Graduate Program in Biomedical Sciences, University of California San Francisco, San Francisco, CA 94143, USA.; Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
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Źródło :
Human molecular genetics [Hum Mol Genet] 2022 May 04; Vol. 31 (9), pp. 1500-1518.
Typ publikacji :
Journal Article
MeSH Terms :
Dopaminergic Neurons*/metabolism
Mitochondrial Proteins*/genetics
Mitochondrial Proteins*/metabolism
Animals ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Male ; Mice ; Substantia Nigra/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease.
Autorzy :
Kamath T; Broad Institute of Harvard and MIT, Stanley Center for Psychiatric Research, Cambridge, MA, USA.; Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA, USA.
Abdulraouf A; Broad Institute of Harvard and MIT, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Burris SJ; Broad Institute of Harvard and MIT, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Langlieb J; Broad Institute of Harvard and MIT, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Gazestani V; Broad Institute of Harvard and MIT, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Nadaf NM; Broad Institute of Harvard and MIT, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Balderrama K; Broad Institute of Harvard and MIT, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Vanderburg C; Broad Institute of Harvard and MIT, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Macosko EZ; Broad Institute of Harvard and MIT, Stanley Center for Psychiatric Research, Cambridge, MA, USA. .; Massachusetts General Hospital, Department of Psychiatry, Boston, MA, USA. .
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Źródło :
Nature neuroscience [Nat Neurosci] 2022 May; Vol. 25 (5), pp. 588-595. Date of Electronic Publication: 2022 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Dopaminergic Neurons*/metabolism
Parkinson Disease*/genetics
Parkinson Disease*/metabolism
Genomics ; Humans ; Substantia Nigra
Czasopismo naukowe
Tytuł :
The role of DCC in the survival of discrete midbrain dopaminergic neuron subpopulations.
Autorzy :
Lawrence AJ; Florey Institute of Neuroscience & Mental Health, Parkville, Victoria, Australia.; Florey Department of Neuroscience & Mental Health, University of Melbourne, Parkville, Victoria, Australia.
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Źródło :
Journal of neurochemistry [J Neurochem] 2022 May; Vol. 161 (3), pp. 217-218. Date of Electronic Publication: 2022 Feb 07.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Dopaminergic Neurons*/physiology
Mesencephalon*/physiology
Dopamine
Opinia redakcyjna
Tytuł :
The netrin-1 receptor DCC promotes the survival of a subpopulation of midbrain dopaminergic neurons: Relevance for ageing and Parkinson's disease.
Autorzy :
Lo PS; Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.; Cone Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.
Rymar VV; Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.; Cone Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.
Kennedy TE; Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Sadikot AF; Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.; Cone Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.
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Źródło :
Journal of neurochemistry [J Neurochem] 2022 May; Vol. 161 (3), pp. 254-265. Date of Electronic Publication: 2022 Feb 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopaminergic Neurons*/metabolism
Parkinson Disease*/genetics
Parkinson Disease*/metabolism
Aging/metabolism ; Animals ; DCC Receptor/metabolism ; Mesencephalon/metabolism ; Mice ; Netrin Receptors/metabolism ; Netrin-1/metabolism
Czasopismo naukowe
Tytuł :
LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons.
Autorzy :
Burbidge K; Graduate Program in Neuroscience, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.
Rademacher DJ; Core Imaging Facility and Department of Microbiology and Immunology, Loyola University of Chicago, Maywood, Illinois, USA.
Mattick J; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University, Chicago, Maywood, Illinois, USA.
Zack S; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University, Chicago, Maywood, Illinois, USA.
Grillini A; Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.
Bousset L; Institut Francois Jacob (Mircen), Cea and Laboratory of Neurodegenerative Diseases, Cnrs, Fontenay-Aux-Roses Cedex, France.
Kwon O; Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.
Kubicki K; Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.
Simon A; Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.
Melki R; Institut Francois Jacob (Mircen), Cea and Laboratory of Neurodegenerative Diseases, Cnrs, Fontenay-Aux-Roses Cedex, France.
Campbell EM; Graduate Program in Neuroscience, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.; Core Imaging Facility and Department of Microbiology and Immunology, Loyola University of Chicago, Maywood, Illinois, USA.
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Źródło :
Autophagy [Autophagy] 2022 May; Vol. 18 (5), pp. 1020-1048. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Dopaminergic Neurons*/metabolism
Galectin 3*/metabolism
Parkinson Disease*/metabolism
alpha-Synuclein*/metabolism
Autophagy/physiology ; Blood Proteins ; Galectins ; Humans ; Lysosomes/metabolism ; Mesencephalon/metabolism ; Tripartite Motif Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Identification of a Potent Human Trace Amine-Associated Receptor 1 Antagonist.
Autorzy :
Decker AM; Center for Drug Discovery, RTI International, Research Triangle Park, North Carolina 27709, United States.
Brackeen MF; Center for Drug Discovery, RTI International, Research Triangle Park, North Carolina 27709, United States.
Mohammadkhani A; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N4N1, Canada.
Kormos CM; Center for Drug Discovery, RTI International, Research Triangle Park, North Carolina 27709, United States.
Hesk D; Center for Drug Discovery, RTI International, Research Triangle Park, North Carolina 27709, United States.
Borgland SL; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N4N1, Canada.
Blough BE; Center for Drug Discovery, RTI International, Research Triangle Park, North Carolina 27709, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2022 Apr 06; Vol. 13 (7), pp. 1082-1095. Date of Electronic Publication: 2022 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Dopaminergic Neurons*/metabolism
Receptors, G-Protein-Coupled*/metabolism
Animals ; Humans ; Mice ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Dopaminergic neurons: linking longevity with reproduction?
Autorzy :
Tian X; Neuroscience Center of Excellence, Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
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Źródło :
Aging [Aging (Albany NY)] 2022 Apr 02; Vol. 14 (7), pp. 2926-2927. Date of Electronic Publication: 2022 Apr 02.
Typ publikacji :
Journal Article
MeSH Terms :
Dopaminergic Neurons*
Longevity*
Reproduction
Czasopismo naukowe
Tytuł :
Age-dependent alterations in key components of the nigrostriatal dopaminergic system and distinct motor phenotypes.
Autorzy :
Fan JP; Jiangsu Province Key Laboratory in Brain diseases, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Xuzhou Medical University, Xuzhou, 221004, China.
Geng HZ; Jiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, School of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.
Ji YW; Jiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, School of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.
Jia T; Jiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, School of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.
Treweek JB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Li AA; Jiangsu Province Key Laboratory in Brain diseases, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Xuzhou Medical University, Xuzhou, 221004, China.
Zhou CY; Jiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. .; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, School of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. .; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. .
Gradinaru V; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Xiao C; Jiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. .; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, School of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. .; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. .
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Źródło :
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2022 Apr; Vol. 43 (4), pp. 862-875. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Dopamine*
Dopaminergic Neurons*
Corpus Striatum ; Humans ; Pars Compacta ; Phenotype ; Substantia Nigra/physiology
Czasopismo naukowe
Tytuł :
Cuprizone-induced dopaminergic hyperactivity and locomotor deficit in zebrafish larvae.
Autorzy :
Liu M; Zhejiang Provincial Clinical Research Center for Mental Illness, The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Zheng P; School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Zheng M; Zhejiang Provincial Clinical Research Center for Mental Illness, The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Zhang W; Department of Pharmacology, College of Pharmacy, Dali University, Dali, Yunnan 671000, China.
Yang F; School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Hong L; School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Yu X; School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: .
Xu H; Zhejiang Provincial Clinical Research Center for Mental Illness, The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Key Laboratory of Alzheimer's Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: .
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Źródło :
Brain research [Brain Res] 2022 Apr 01; Vol. 1780, pp. 147802. Date of Electronic Publication: 2022 Jan 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cuprizone/*pharmacology
Dopamine/*metabolism
Dopaminergic Neurons/*drug effects
Motor Activity/*drug effects
Synaptic Transmission/*drug effects
Animals ; Behavior, Animal/drug effects ; Disease Models, Animal ; Dopaminergic Neurons/metabolism ; Zebrafish
Czasopismo naukowe

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