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Wyszukujesz frazę ""Dose-Response Relationship, Drug"" wg kryterium: Temat


Tytuł:
Subgroup-specific dose finding for phase I-II trials using Bayesian clustering.
Autorzy:
Curtis A; Department of Biostatistics, University of Iowa, Iowa City, Iowa, USA.; Department of Statistics, Data and Analytics, Eli Lilly and Company, Indianapolis, Indiana, USA.
Smith B; Department of Biostatistics, University of Iowa, Iowa City, Iowa, USA.
Chapple AG; Biostatistics Program, School of Public Health, LSU Health Sciences Center, New Orleans, Louisiana, USA.
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Źródło:
Statistics in medicine [Stat Med] 2022 Jul 20; Vol. 41 (16), pp. 3164-3179. Date of Electronic Publication: 2022 Apr 16.
Typ publikacji:
Journal Article
MeSH Terms:
Dose-Response Relationship, Drug*
Neoplasms*/drug therapy
Bayes Theorem ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Cluster Analysis ; Computer Simulation ; Humans
Czasopismo naukowe
Tytuł:
A randomized study of the safety and pharmacokinetics of GSK3358699, a mononuclear myeloid-targeted bromodomain and extra-terminal domain inhibitor.
Autorzy:
Brown JA; GlaxoSmithKline R&D, Cambridge, MA, USA.
Bal J; GlaxoSmithKline R&D Stevenage, Stevenage, UK.
Simeoni M; GlaxoSmithKline, GSK House, Brentford, UK.
Williams P; GlaxoSmithKline, GSK House, Brentford, UK.
Mander PK; GlaxoSmithKline R&D Stevenage, Stevenage, UK.
Soden PE; GlaxoSmithKline R&D Stevenage, Stevenage, UK.
Daga S; GlaxoSmithKline, Uxbridge, UK.
Fahy WA; GlaxoSmithKline, GSK House, Brentford, UK.
Wong GK; GlaxoSmithKline R&D Stevenage, Stevenage, UK.
Bloomer JC; GlaxoSmithKline R&D, Ware, Hertfordshire, UK.
Erwig L; GlaxoSmithKline R&D Stevenage, Stevenage, UK.; Johnson & Johnson, London, UK.
Cui Y; GlaxoSmithKline, GSK House, Brentford, UK.
Fernando D; GlaxoSmithKline R&D Clinical Unit, Addenbrooke's Hospital, Cambridge, UK.
Carnaghan H; GlaxoSmithKline R&D Clinical Unit, Addenbrooke's Hospital, Cambridge, UK.
Banham-Hall EJ; GlaxoSmithKline R&D Clinical Unit, Addenbrooke's Hospital, Cambridge, UK.
Hopkins S; GlaxoSmithKline R&D Clinical Unit, Addenbrooke's Hospital, Cambridge, UK.
Davis BG; GlaxoSmithKline R&D Clinical Unit, Addenbrooke's Hospital, Cambridge, UK.
Oliveira JJD; GlaxoSmithKline R&D Clinical Unit, Addenbrooke's Hospital, Cambridge, UK.
Prinjha RK; GlaxoSmithKline R&D Stevenage, Stevenage, UK.
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Źródło:
British journal of clinical pharmacology [Br J Clin Pharmacol] 2022 May; Vol. 88 (5), pp. 2140-2155. Date of Electronic Publication: 2021 Dec 18.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Drug*
Area Under Curve ; Cross-Over Studies ; Double-Blind Method ; Healthy Volunteers ; Humans ; Male
Czasopismo naukowe
Tytuł:
Single-dose of LC51-0255, a selective S1P 1 receptor modulator, showed dose-dependent and reversible reduction of absolute lymphocyte count in humans.
Autorzy:
Won Lee S; Department of Clinical Pharmacology and Therapeutics, Hanyang University Seoul Hospital, Seoul, South Korea.
Hwang I; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.
Oh J; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.
Lee S; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.
Jang IJ; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.
Yu KS; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2022 Apr; Vol. 15 (4), pp. 1074-1083. Date of Electronic Publication: 2022 Jan 23.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Drug*
Administration, Oral ; Double-Blind Method ; Half-Life ; Healthy Volunteers ; Humans ; Lymphocyte Count
Czasopismo naukowe
Tytuł:
Effect of corticosteroid dosing on outcomes in high-grade immune checkpoint inhibitor hepatitis.
Autorzy:
Li M; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham & Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Division of Gastroenterology, University of California San Francisco, San Francisco, California, USA.
Wong D; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham & Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
Vogel AS; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham & Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
Sack JS; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham & Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
Rahma OE; Harvard Medical School, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Hodi FS; Harvard Medical School, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Zucker SD; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham & Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
Grover S; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham & Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
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Źródło:
Hepatology (Baltimore, Md.) [Hepatology] 2022 Mar; Vol. 75 (3), pp. 531-540. Date of Electronic Publication: 2021 Dec 07.
Typ publikacji:
Journal Article; Multicenter Study
MeSH Terms:
Chemical and Drug Induced Liver Injury*/blood
Chemical and Drug Induced Liver Injury*/diagnosis
Chemical and Drug Induced Liver Injury*/drug therapy
Chemical and Drug Induced Liver Injury*/etiology
Dose-Response Relationship, Drug*
Dose-Response Relationship, Immunologic*
Methylprednisolone*/administration & dosage
Methylprednisolone*/adverse effects
Alanine Transaminase/*blood
Immune Checkpoint Inhibitors/*adverse effects
Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/adverse effects ; Drug Resistance ; Female ; Humans ; Immune Checkpoint Inhibitors/administration & dosage ; Immunosuppression Therapy/methods ; Liver Function Tests/methods ; Male ; Middle Aged ; Neoplasms/drug therapy ; Outcome and Process Assessment, Health Care ; Retrospective Studies ; Risk Assessment
Czasopismo naukowe
Tytuł:
EDP-305 in patients with NASH: A phase II double-blind placebo-controlled dose-ranging study.
Autorzy:
Ratziu V; Sorbonne Université, ICAN, Hospital Pitié-Salpêtrière, INSERM UMRS 1138 CRC, Paris, France.
Rinella ME; Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Neuschwander-Tetri BA; Saint Louis University School of Medicine, St. Louis, MO, United States.
Lawitz E; Texas Liver Institute, San Antonio, TX United States.
Denham D; Clinical Trials of Texas, Inc., San Antonio, TX, United States.
Kayali Z; Inland Empire Liver Foundation, Rialto, CA, United States.
Sheikh A; GI Specialists of Georgia, Marietta, GA United States.
Kowdley KV; Liver Institute Northwest and Elson S. Floyd College of Medicine, Washington State University, Seattle, WA, United States.
Desta T; Precision Research Institute, San Diego, CA, United States.
Elkhashab M; Toronto Liver Center, Toronto, Ontario, Canada.
DeGrauw J; Synexus - Wasatch Peak Family Practice, Layton, UT, United States.
Goodwin B; Enanta Pharmaceuticals, Inc, Watertown, MA, United States.
Ahmad A; Enanta Pharmaceuticals, Inc, Watertown, MA, United States.
Adda N; Enanta Pharmaceuticals, Inc, Watertown, MA, United States. Electronic address: .
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Źródło:
Journal of hepatology [J Hepatol] 2022 Mar; Vol. 76 (3), pp. 506-517. Date of Electronic Publication: 2021 Nov 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Drug*
Non-alcoholic Fatty Liver Disease/*drug therapy
Steroids/*administration & dosage
Administration, Oral ; Adult ; Analysis of Variance ; Canada ; Double-Blind Method ; Female ; France ; Germany ; Humans ; Liver/pathology ; Male ; Middle Aged ; New Zealand ; Placebos ; Receptors, Cytoplasmic and Nuclear/administration & dosage ; Receptors, Cytoplasmic and Nuclear/therapeutic use ; Steroids/therapeutic use ; Treatment Outcome ; United Kingdom ; United States
Czasopismo naukowe
Tytuł:
Pharmacokinetics, Safety, and Tolerability of the α 2C -Adrenoreceptor Antagonist BAY 1193397 in Healthy Male Subjects.
Autorzy:
Kapsa S; Clinical Pharmacokinetics, BAYER AG, Wuppertal, Germany.
Thuss U; Bioanalytics, BAYER AG, Wuppertal, Germany.
Boxnick S; CRS Clinical Research Services, Wuppertal GmbH, Wuppertal, Germany.
Schaumann F; CRS Clinical Research Services, Wuppertal GmbH, Wuppertal, Germany.
Schultz A; CRS Clinical Research Services, Mannheim GmbH, Mannheim, Germany.
Unger S; Research and Early Development Statistics, BAYER AG, Wuppertal, Germany.
Otto C; Clinical Experimentation Cardiovascular, BAYER AG, Wuppertal, Germany.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2022 Mar; Vol. 11 (3), pp. 296-308. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Drug*
Administration, Oral ; Area Under Curve ; Biological Availability ; Clinical Trials, Phase I as Topic ; Healthy Volunteers ; Humans ; Male ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł:
Education level and misuse of antibiotics in the general population: a systematic review and dose-response meta-analysis.
Autorzy:
Mallah N; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.; Department of Preventive Medicine, University of Santiago de Compostela, R/ San Francisco, s/n, 15782, Santiago de Compostela, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBER-ESP), Madrid, Spain.; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Orsini N; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Figueiras A; Department of Preventive Medicine, University of Santiago de Compostela, R/ San Francisco, s/n, 15782, Santiago de Compostela, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBER-ESP), Madrid, Spain.; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Takkouche B; Department of Preventive Medicine, University of Santiago de Compostela, R/ San Francisco, s/n, 15782, Santiago de Compostela, Spain. .; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBER-ESP), Madrid, Spain. .; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. .
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Źródło:
Antimicrobial resistance and infection control [Antimicrob Resist Infect Control] 2022 Feb 03; Vol. 11 (1), pp. 24. Date of Electronic Publication: 2022 Feb 03.
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms:
Dose-Response Relationship, Drug*
Educational Status*
Anti-Bacterial Agents/*therapeutic use
Drug Misuse/*statistics & numerical data
Humans
Czasopismo naukowe
Tytuł:
Upadacitinib pharmacokinetics and exposure-response analyses of efficacy and safety in psoriatic arthritis patients - Analyses of phase III clinical trials.
Autorzy:
Muensterman E; Clinical Pharmacology and Pharmacometrics, AbbVie, North Chicago, Illinois, USA.
Engelhardt B; Clinical Pharmacology and Pharmacometrics, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen am Rhein, Germany.
Gopalakrishnan S; Clinical Pharmacology and Pharmacometrics, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen am Rhein, Germany.
Anderson JK; Immunology Clinical Development, AbbVie, North Chicago, Illinois, USA.
Mohamed MF; Clinical Pharmacology and Pharmacometrics, AbbVie, North Chicago, Illinois, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2022 Jan; Vol. 15 (1), pp. 267-278. Date of Electronic Publication: 2021 Oct 27.
Typ publikacji:
Clinical Trial, Phase III; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Drug*
Arthritis, Psoriatic/*drug therapy
Heterocyclic Compounds, 3-Ring/*pharmacokinetics
Janus Kinase Inhibitors/*pharmacokinetics
Adult ; Female ; Heterocyclic Compounds, 3-Ring/administration & dosage ; Humans ; Male ; Middle Aged ; Safety ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Evaluation of the safety, tolerability, and pharmacokinetics of RO7049389 in healthy Chinese volunteers.
Autorzy:
Wu X; Phase I Clinical Research Center, Huashan Hospital, Fudan University, Shanghai, China.
Feng S; Pharmaceutical Sciences, Roche Innovation Center Shanghai, Shanghai, China.
Zhang J; Phase I Clinical Research Center, Huashan Hospital, Fudan University, Shanghai, China.
Zhang W; Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
Zhang Y; Pharmaceutical Sciences, Roche Innovation Center Shanghai, Shanghai, China.
Zhu M; I2O DTA, Roche Innovation Center Shanghai, Shanghai, China.
Triyatni M; Early Development Safety, Roche Pharma, Basel, Switzerland.
Zhao N; Biostatistics, Roche Pharma Product Development Shanghai, Shanghai, China.
Bo Q; I2O DTA, Roche Innovation Center Shanghai, Shanghai, China.
Jin Y; Pharmaceutical Sciences, Roche Innovation Center Shanghai, Shanghai, China.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2022 Jan; Vol. 15 (1), pp. 195-203. Date of Electronic Publication: 2021 Sep 25.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Drug*
Drug Tolerance*
Healthy Volunteers*
Safety*
Antiviral Agents/*pharmacokinetics
Adolescent ; Adult ; China ; Double-Blind Method ; Female ; Hepatitis B, Chronic/drug therapy ; Humans ; Male ; Middle Aged ; Young Adult
Czasopismo naukowe
Tytuł:
Required dose of sugammadex or neostigmine for reversal of vecuronium-induced shallow residual neuromuscular block at a train-of-four ratio of 0.3.
Autorzy:
He J; Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, China.
He H; Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, China.
Li X; Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, China.
Sun M; Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, China.
Lai Z; Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, China.
Xu B; Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, China.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2022 Jan; Vol. 15 (1), pp. 234-243. Date of Electronic Publication: 2021 Nov 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Drug*
Delayed Emergence from Anesthesia/*chemically induced
Delayed Emergence from Anesthesia/*drug therapy
Neostigmine/*administration & dosage
Neostigmine/*pharmacology
Sugammadex/*administration & dosage
Sugammadex/*pharmacology
Vecuronium Bromide/*pharmacology
Humans
Czasopismo naukowe
Tytuł:
Metronomic chemotherapy regimens and targeted therapies in non-Hodgkin lymphoma: The best of two worlds.
Autorzy:
Cox MC; Department of Haematology, King's College Hospital NHS Trust, London, UK; University Hospital Sant'Andrea, Rome, Italy.
Bocci G; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address: .
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Źródło:
Cancer letters [Cancer Lett] 2022 Jan 01; Vol. 524, pp. 144-150. Date of Electronic Publication: 2021 Oct 19.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Administration, Metronomic*
Dose-Response Relationship, Drug*
Lymphoma, Non-Hodgkin/*drug therapy
Lymphoma, T-Cell/*drug therapy
Aged ; Geriatric Assessment ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylases/genetics ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Lymphoma, Non-Hodgkin/genetics ; Lymphoma, Non-Hodgkin/pathology ; Lymphoma, T-Cell/pathology ; Phosphatidylinositol 3-Kinases/genetics ; Rituximab/therapeutic use ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł:
Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial.
Autorzy:
Lau DCW; Julia McFarlane Diabetes Research Centre and Libin Cardiovascular Institute of Alberta, University of Calgary Cumming School of Medicine, Calgary, AB, Canada. Electronic address: .
Erichsen L; Novo Nordisk A/S, Søborg, Denmark.
Francisco AM; Novo Nordisk A/S, Søborg, Denmark.
Satylganova A; Novo Nordisk A/S, Søborg, Denmark.
le Roux CW; Diabetes Complications Research Centre, University College Dublin, Dublin, Ireland.
McGowan B; Guy's & St Thomas' Hospital, Department of Diabetes and Endocrinology, London, UK.
Pedersen SD; C-ENDO Diabetes & Endocrinology Clinic Calgary, Calgary, AB, Canada.
Pietiläinen KH; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Obesity Center, Abdominal Center, Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Rubino D; Washington Center for Weight Management, Arlington, VA, USA.
Batterham RL; National Institute of Health Research, UCLH Biomedical Research Centre, London, UK; Centre for Obesity Research, Department of Medicine, University College London, London, UK.
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Źródło:
Lancet (London, England) [Lancet] 2021 Dec 11; Vol. 398 (10317), pp. 2160-2172. Date of Electronic Publication: 2021 Nov 16.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms:
Dose-Response Relationship, Drug*
Islet Amyloid Polypeptide/*therapeutic use
Obesity/*drug therapy
Weight Loss/*drug effects
Africa ; Body Mass Index ; Double-Blind Method ; Europe ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Injections, Subcutaneous ; Liraglutide/administration & dosage ; Male ; Middle Aged ; North America
Czasopismo naukowe
Tytuł:
Potential mental and physical benefits of supplementation with a high-dose, B-complex multivitamin/mineral supplement: What is the evidence?
Autorzy:
Sarris J; NICM Health Research Institute. Western Sydney University.
Mehta B
Óvári V; Bayer Consumer Care AG.
Ferreres Giménez I; Bayer Hispania, S. L. Consumer Health.
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Transliterated Title:
Posibles beneficios mentales y físicos de la suplementación con un preparado multivitamínico/mineral del complejo B en dosis altas: ¿Qué evidencia hay?
Źródło:
Nutricion hospitalaria [Nutr Hosp] 2021 Dec 09; Vol. 38 (6), pp. 1277-1286.
Typ publikacji:
Journal Article; Systematic Review
MeSH Terms:
Dose-Response Relationship, Drug*
Dietary Supplements/*standards
Vitamin B Complex/*administration & dosage
Adult ; Double-Blind Method ; Female ; Humans ; Male ; Randomized Controlled Trials as Topic/statistics & numerical data ; Vitamin B Complex/pharmacology
Czasopismo naukowe
Tytuł:
Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers.
Autorzy:
Amore BM; Esperion Therapeutics, Inc., Ann Arbor, Michigan, USA.
Cramer CT; Nonclinical Pharma Solutions, LLC, Dexter, Michigan, USA.
MacDougall DE; Esperion Therapeutics, Inc., Ann Arbor, Michigan, USA.
Sasiela WJ; Esperion Therapeutics, Inc., Ann Arbor, Michigan, USA.
Emery MG; Esperion Therapeutics, Inc., Ann Arbor, Michigan, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2021 Nov; Vol. 14 (6), pp. 2487-2496. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Drug*
Healthy Volunteers*
Long QT Syndrome*
Arrhythmias, Cardiac/*drug therapy
Dicarboxylic Acids/*pharmacology
Enzyme Inhibitors/*pharmacology
Fatty Acids/*pharmacology
Heart Rate/*drug effects
Adolescent ; Adult ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Young Adult
Czasopismo naukowe
Tytuł:
Sedation - Effects of disorders of abuse on therapeutic efficacy (SEDATE): A retrospective cohort study.
Autorzy:
Albala L; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, United States of America. Electronic address: .
Loesche MA; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, United States of America.
Hayes BD; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, United States of America; Department of Pharmacy, Massachusetts General Hospital, Boston, MA, United States of America.
McEvoy DS; Digital Health eCare, Mass General Brigham, Boston, MA, United States of America.
Filbin M; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, United States of America.
Dutta S; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, United States of America; Digital Health eCare, Mass General Brigham, Boston, MA, United States of America.
Eyre AJ; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, United States of America.
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Źródło:
The American journal of emergency medicine [Am J Emerg Med] 2021 Nov; Vol. 49, pp. 294-299. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji:
Journal Article
MeSH Terms:
Dose-Response Relationship, Drug*
Hypnotics and Sedatives/*administration & dosage
Substance-Related Disorders/*complications
Adult ; Aged ; Cohort Studies ; Data Mining ; Emergency Service, Hospital/organization & administration ; Emergency Service, Hospital/statistics & numerical data ; Female ; Humans ; Hypnotics and Sedatives/therapeutic use ; Male ; Middle Aged ; Retrospective Studies ; Substance-Related Disorders/physiopathology ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Comparison of fluid resuscitation weight-based dosing strategies in obese patients with severe sepsis.
Autorzy:
Kaseer HS; Department of Pharmacy, University of Florida Health Shands Hospital, Gainesville, FL, United States of America. Electronic address: .
Patel R; Department of Pharmacy, University of Florida Health Shands Hospital, Gainesville, FL, United States of America. Electronic address: .
Tucker C; Department of Pharmacy, University of Florida Health Shands Hospital, Gainesville, FL, United States of America. Electronic address: .
Elie MC; Department of Emergency Medicine, University of Florida Health Shands Hospital, Gainesville, FL, United States of America. Electronic address: .
Staley BJ; Department of Pharmacy, University of Florida Health Shands Hospital, Gainesville, FL, United States of America. Electronic address: .
Tran N; University of Florida College of Pharmacy, Gainesville, FL, United States of America.
Lemon S; Department of Pharmacy, University of Florida Health Shands Hospital, Gainesville, FL, United States of America. Electronic address: .
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Źródło:
The American journal of emergency medicine [Am J Emerg Med] 2021 Nov; Vol. 49, pp. 268-272. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji:
Journal Article
MeSH Terms:
Dose-Response Relationship, Drug*
Fluid Therapy/*standards
Obesity/*complications
Sepsis/*therapy
Aged ; Female ; Fluid Therapy/methods ; Fluid Therapy/statistics & numerical data ; Humans ; Male ; Middle Aged ; Obesity/epidemiology ; Obesity/physiopathology ; Resuscitation/methods ; Resuscitation/standards ; Resuscitation/statistics & numerical data ; Retrospective Studies ; Sepsis/epidemiology ; Sepsis/physiopathology
Czasopismo naukowe
Tytuł:
Synthesis, molecular docking, and evaluation of antibacterial activity of 1,2,4-triazole-norfloxacin hybrids.
Autorzy:
Yang P; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangdong Detection Center of Microbiology, Guangzhou 510070, China; Guangdong Demay New Materials Technology Co. Ltd., Guangzhou 510070, China.
Luo JB; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Wang ZZ; School of Chemistry and Chemical Engineering, Guangzhou University, 230 Wai Huan Xi Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
Zhang LL; College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, Henan 471000, China.
Feng J; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangdong Detection Center of Microbiology, Guangzhou 510070, China.
Xie XB; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangdong Detection Center of Microbiology, Guangzhou 510070, China. Electronic address: .
Shi QS; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangdong Detection Center of Microbiology, Guangzhou 510070, China. Electronic address: .
Zhang XG; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2021 Oct; Vol. 115, pp. 105270. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Drug*
Molecular Docking Simulation*
Anti-Bacterial Agents/*pharmacology
Norfloxacin/*pharmacology
Triazoles/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Crystallography, X-Ray ; Escherichia coli/drug effects ; Microbial Sensitivity Tests ; Molecular Structure ; Norfloxacin/chemical synthesis ; Norfloxacin/chemistry ; Pseudomonas aeruginosa/drug effects ; Staphylococcus aureus/drug effects ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry
Czasopismo naukowe
Tytuł:
Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment.
Autorzy:
El-Khateeb E; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester M13 9PT, U.K.; Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt.
Achour B; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester M13 9PT, U.K.
Al-Majdoub ZM; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester M13 9PT, U.K.
Barber J; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester M13 9PT, U.K.
Rostami-Hodjegan A; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester M13 9PT, U.K.; Certara UK Ltd. (Simcyp Division), Sheffield S1 2BJ, U.K.
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Źródło:
Molecular pharmaceutics [Mol Pharm] 2021 Sep 06; Vol. 18 (9), pp. 3563-3577. Date of Electronic Publication: 2021 Aug 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Drug*
Models, Biological*
Hepatobiliary Elimination/*physiology
Liver/*metabolism
Liver Cirrhosis/*physiopathology
Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Humans ; Liver/cytology ; Liver/pathology ; Liver Cirrhosis/diagnosis ; Male ; Microsomes, Liver ; Middle Aged ; Proteomics ; Severity of Illness Index
Czasopismo naukowe
Tytuł:
Design and conduct considerations for studies in patients with impaired renal function.
Autorzy:
Ravenstijn P; qPharmetra LLC, Nijmegen, The Netherlands.
Chetty M; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa.
Manchandani P; Clinical Pharmacology and Exploratory Development, Astellas Pharma US Inc., Northbrook, Illinois, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2021 Sep; Vol. 14 (5), pp. 1689-1704. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji:
Journal Article
MeSH Terms:
Dose-Response Relationship, Drug*
Models, Biological*
Acute Kidney Injury/*complications
Kidney/*physiopathology
Kidney Failure, Chronic/*complications
Acute Kidney Injury/physiopathology ; Clinical Trials as Topic ; Computer Simulation ; Glomerular Filtration Rate/physiology ; Humans ; Kidney Failure, Chronic/physiopathology ; Renal Elimination/physiology
Czasopismo naukowe
Tytuł:
Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments.
Autorzy:
Agathokleous E; Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters (CIC-FEMD), Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu China.; Research Center for Global Changes and Ecosystem Carbon Sequestration & Mitigation, School of Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu China.
Barceló D; Institute of Environmental Assessment and Water Research, IDAEA-CSIC; Barcelona 08034, Spain.; Catalan Institute for Water Research, ICRA-CERCA; Girona 17003, Spain.
Aschner M; Department of Molecular Pharmacology, Albert Einstein College of Medicine; Bronx, New York 10461, United States.
Azevedo RA; Departamento de Genética, Escola Superior de Agricultura 'Luiz de Queiroz'/Universidade de São Paulo (ESALQ/USP); São Paulo CEP 13418-900, Brazil.
Bhattacharya P; KTH-international Groundwater Arsenic Research Group, Department of Sustainable Development, Environmental Science and Engineering, KTH Royal Institute of Technology; Stockholm SE-100 44, Sweden.
Costantini D; Unité Physiologie Moléculaire et Adaptation (PhyMA), UMR 7221 Muséum National d'Histoire Naturelle; CNRS, 7 Rue Cuvier, 75005 Paris, France.
Cutler GC; Department of Plant, Food, and Environmental Sciences, Agricultural Campus, Dalhousie University; Truro, Nova Scotia B2N 5E3, Canada.
De Marco A; ENEA, CR Casaccia, SSPT-PVS; Rome 00123, Italy.
Docea AO; Department of Toxicology, University of Medicine and Pharmacy of Craiova; Craiova 200349, Romania.
Dórea JG; Faculdade de Ciências da Saúde, Universidade de Brasília; Brasília 70919-970, Brazil.
Duke SO; National Center for Natural Products Research, School of Pharmacy, University of Mississippi; Mississippi 38677, United States.
Efferth T; Johannes Gutenberg University, Institute of Pharmaceutical and Biomedical Sciences, Department of Pharmaceutical Biology; Mainz 55128, Germany.
Fatta-Kassinos D; Department of Civil and Environmental Engineering and Nireas-International Water Research Centre, School of Engineering, University of Cyprus; P.O. Box 20537, Nicosia 1678, Cyprus.
Fotopoulos V; Department of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology; Lemesos 3603, Cyprus.
Ginebreda A; Environmental Chemistry, IDAEA-CSIC, c/Jordi Girona 18-26, Barcelona 08034, Spain.
Guedes RNC; Departamento de Entomologia, Universidade Federal de Viçosa;Viçosa, Minas Gerais 36570-900, Brazil.
Hayes AW; Center for Environmental/Occupational Risk Analysis & Management, University of South Florida, College of Public Health; Tampa, Florida 33612, United States.; Michigan State University; East Lansing, Michigan 48824, United States.
Iavicoli I; Department of Public Health, Section of Occupational Medicine, University of Naples Federico II; Naples 80131, Italy.
Kalantzi OI; Department of Environment, University of the Aegean; Mytilene 81100, Greece.
Koike T; Research Faculty of Agriculture, Hokkaido University; Sapporo, Hokkaido 060-8589, Japan.
Kouretas D; Department of Biochemistry-Biotechnology, University of Thessaly, Larisa 41500, Greece.
Kumar M; School of Engineering, University of Petroleum and Energy Studies; Dehradun 248007, India.
Manautou JE; Pharmaceutical Science, University of Connecticut, Storrs, Connecticut 06269, United States.
Moore MN; European Centre for Environment & Human Health (ECEHH), University of Exeter Medical School, Knowledge Spa, Royal Cornwall Hospital; Truro TR1 3HD, U.K.; Plymouth Marine Laboratory; Plymouth, Devon PL1 3DH, U.K.; School of Biological & Marine Sciences, University of Plymouth; Plymouth PL 4 8AA, U.K.
Paoletti E; Institute of Research on Terrestrial Ecosystems, National Research Council; Sesto Fiorentino 50019, Italy.
Peñuelas J; CSIC, Global Ecology Unit CREAF-CSIC-UAB; Bellaterra, Catalonia 08193, Spain.; CREAF; Cerdanyola del Vallès, Catalonia 08193, Spain.
Picó Y; Environmental and Food Safety Research Group (SAMA-UV), Desertification Research Centre (CIDE), Universitat de València-CSIC-GV; Valencia 46113, Spain.
Reiter RJ; Department of Cell Systems and Anatomy, Joe R. and Teresa Lozano Long School of Medicine, UT Health San Antonio; San Antonio, Texas 78229, United States.
Rezaee R; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences,Mashhad 91779-43335, Iran.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 91779-43335, Iran.
Rinklebe J; University of Wuppertal, School of Architecture and Civil Engineering, Institute of Foundation Engineering, Water, and Waste-Management, Laboratory of Soil, and Groundwater-Management; Wuppertal 42285, Germany.
Rocha-Santos T; Centre for Environmental and Marine Studies (CESAM) & Department of Chemistry, University of Aveiro; Aveiro 3810-193, Portugal.
Sicard P; ARGANS, 260 route du Pin Montard, Biot 06410, France.
Sonne C; Aarhus University, Department of Bioscience, Arctic Research Centre (ARC); Roskilde DK-4000, Denmark.; Henan Province Engineering Research Center for Biomass Value-added Products, School of Forestry, Henan Agricultural University; Zhengzhou 450002, China.
Teaf C; Institute of Science & Public Affairs, Florida State University; Tallahassee, Florida 32306, United States.
Tsatsakis A; Laboratory of Toxicology, Medical School, University of Crete; Heraklion 71003, Greece.
Vardavas AI; Laboratory of Toxicology, Medical School, University of Crete; Heraklion 71003, Greece.
Wang W; Key Laboratory of Forest Plant Ecology, Northeast Forestry University; Harbin 150040, China.; Northeast Institute of Geography and Agroecology, Chinese Academy of Science; Changchun 130102, China.
Zeng EY; Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University; Guangzhou 511443, China.
Calabrese EJ; Department of Environmental Health Sciences, University of Massachusetts; Amherst, Massachusetts 01003, United States.
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Źródło:
Environmental science & technology [Environ Sci Technol] 2022 Aug 16; Vol. 56 (16), pp. 11095-11099. Date of Electronic Publication: 2022 Jul 25.
Typ publikacji:
Journal Article
MeSH Terms:
Hormesis*
Dose-Response Relationship, Drug ; Risk Assessment
Czasopismo naukowe

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