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Wyszukujesz frazę ""Double-Blind Method"" wg kryterium: Temat


Tytuł:
The Effect of Oral Montelukast in Controlling Asthma Attacks in Children: A Randomized Double-blind Placebo Control Study.
Autorzy:
Jafari M; Division of Infectious Diseases, Department of Pediatrics, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran. .
Sobhani M; Department of Pediatrics, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran. .
Eftekhari K; Division of Gastroenterology, Department of Pediatrics, Pediatric Gastroenterology and Hepatology Research Center, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran. dr_k_.
Malekiantaghi A; Division of Gastroenterology, Department of Pediatrics, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran. armen_.
Gharagozlou M; Department of Allergy and Clinical Immunology, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran. .
Shafiei A; Division of Allergy and Clinical Immunology, Department of Pediatrics, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran. .
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Źródło:
Iranian journal of allergy, asthma, and immunology [Iran J Allergy Asthma Immunol] 2023 Oct 29; Vol. 22 (5), pp. 413-419. Date of Electronic Publication: 2023 Oct 29.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Anti-Asthmatic Agents*/therapeutic use
Asthma*/diagnosis
Asthma*/drug therapy
Quinolines*/therapeutic use
Child ; Humans ; Iran ; Acetates/therapeutic use ; Double-Blind Method
Czasopismo naukowe
Tytuł:
Dupilumab Efficacy in Patients with Type 2 Asthma with and without Elevated Blood Neutrophils.
Autorzy:
Bleecker ER; University of Arizona, College of Medicine, Division of Genomics and Precision Medicine, Department of Medicine, 1230 North Cherry Street, Suite 251, Tucson, AZ 85721, USA.
Panettieri RA Jr; Child Health Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Lugogo NL; University of Michigan, Ann Arbor, MI, USA.
Corren J; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Daizadeh N; Sanofi, Cambridge, MA, USA.
Jacob-Nara JA; Sanofi, Bridgewater, NJ, USA.
Deniz Y; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
Rowe PJ; Sanofi, Bridgewater, NJ, USA.
Khodzhayev A; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
Soler X; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
Ferro TJ; Sanofi, Bridgewater, NJ, USA.
Hansen CN; Sanofi, Bridgewater, NJ, USA.
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Źródło:
Journal of immunology research [J Immunol Res] 2023 Oct 19; Vol. 2023, pp. 9943584. Date of Electronic Publication: 2023 Oct 19 (Print Publication: 2023).
Typ publikacji:
Clinical Trial; Journal Article
MeSH Terms:
Anti-Asthmatic Agents*/therapeutic use
Asthma*/drug therapy
Humans ; Biomarkers ; Double-Blind Method ; Neutrophils
Czasopismo naukowe
Tytuł:
House dust mite subcutaneous immunotherapy has sustained long-term effectiveness on allergic rhinitis and asthma: A 10-year follow-up.
Autorzy:
Rodriguez-Plata E; Allergy Department, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
Callero Viera A; Allergy Department, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
Ruiz-Garcia M; Medical Affairs and Clinical Department, LETI Pharma, Madrid, Spain.
Gomez-Cardenosa A; Medical Affairs and Clinical Department, LETI Pharma, Madrid, Spain.
Nieto E; Medical Affairs and Clinical Department, LETI Pharma, Madrid, Spain.
García-Robaina JC; Allergy Department, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
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Źródło:
Immunity, inflammation and disease [Immun Inflamm Dis] 2023 Oct; Vol. 11 (10), pp. e1004.
Typ publikacji:
Controlled Clinical Trial; Journal Article
MeSH Terms:
Asthma*/drug therapy
Rhinitis, Allergic*/therapy
Adult ; Animals ; Humans ; Allergens/therapeutic use ; Dermatophagoides pteronyssinus ; Desensitization, Immunologic ; Follow-Up Studies ; Pyroglyphidae ; Double-Blind Method
Czasopismo naukowe
Tytuł:
Long-term effectiveness of benralizumab in severe eosinophilic asthma patients treated for 96-weeks: data from the ANANKE study.
Autorzy:
Vultaggio A; Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy. .
Aliani M; UO Pneumologia e Pneumologia Riabilitativa, ICS Maugeri, IRCCS Bari, Bari, Italy.
Altieri E; Reparto di Pneumologia, P.O. Garbagnate, Milanese, Italy.
Bracciale P; Reparto di Pneumologia, Ospedale Ostuni, Ostuni, BR, Italy.
Brussino L; Dipartimento di Scienze Mediche, SSDDU Allergologia e Immunologia Clinica, Università degli Studi di Torino, AO Ordine Mauriziano Umberto I, Torino, Italy.
Caiaffa MF; Cattedra e Scuola di Allergologia e Immunologia Clinica, Dipartimento di Scienze Mediche, Università di Foggia, Foggia, Italy.
Cameli P; Respiratory Diseases and Lung Transplantation, Department of Medical and Surgical Sciences and Neurosciences, Siena University Hospital, Siena, Italy.
Canonica GW; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.; Personalized Medicine Center: Asthma and Allergology, Humanitas Research Hospital, Rozzano, MI, Italy.
Caruso C; Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico A. Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Centanni S; Respiratory Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
D'Amato M; UOSD Malattie Respiratorie 'Federico II', Ospedale Monaldi, AO Dei Colli, Naples, Italy.
De Michele F; UOC Pneumologia e Fisiopatologia Respiratoria, AORN A. Cardarelli, Naples, Italy.
Del Giacco S; Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Di Marco F; Department of Health Sciences, Università degli Studi di Milano, Pneumologia, ASST Papa Giovanni XXIII, Bergamo, Italy.
Menzella F; UOC Pneumologia, Ospedale 'S. Valentino', AULSS 2 Marca Trevigiana, Montebelluna, TV, Italy.
Pelaia G; Dipartimento di Scienze della Salute, Università Magna Graecia, Catanzaro, Italy.
Rogliani P; Division of Respiratory Medicine, University Hospital 'Tor Vergata', Rome, Italy.; Unit of Respiratory Medicine, Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Romagnoli M; UOC Pneumologia, AULSS 2 Marca Trevigiana, Treviso, Italy.
Schino P; Fisiopatologia Respiratoria, Ospedale Generale Regionale, Ente Ecclesiastico 'F. Miulli', Acquaviva delle Fonti, BA, Italy.
Senna G; Department of Medicine, University of Verona, Verona, Italy.; Allergy Unit and Asthma Center, Verona University Hospital, Verona, Italy.
Benci M; Medical Affairs R&I, AstraZeneca, Milan, Italy.
Boarino S; Medical Evidence R&I, AstraZeneca, Milan, Italy.
Schroeder JW; Allergy and Clinical Immunology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
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Źródło:
Respiratory research [Respir Res] 2023 May 20; Vol. 24 (1), pp. 135. Date of Electronic Publication: 2023 May 20.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Asthmatic Agents*/adverse effects
Asthma*/diagnosis
Asthma*/drug therapy
Asthma*/chemically induced
Pulmonary Eosinophilia*/diagnosis
Pulmonary Eosinophilia*/drug therapy
Female ; Male ; Humans ; Retrospective Studies ; Disease Progression ; Double-Blind Method ; Eosinophils ; Adrenal Cortex Hormones/therapeutic use
Czasopismo naukowe
Tytuł:
Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma.
Autorzy:
Sandhu Y; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Harada N; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.; Research Institute for Diseases of Old Ages, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.; Atopy (Allergy) Research Center, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Sasano H; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Harada S; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.; Atopy (Allergy) Research Center, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Ueda S; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Takeshige T; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Tanabe Y; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Ishimori A; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Matsuno K; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Abe S; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Nagaoka T; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Ito J; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Chiba A; Department of Immunology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
Akiba H; Department of Immunology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
Atsuta R; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Izuhara K; Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga 849-8501, Japan.
Miyake S; Department of Immunology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
Takahashi K; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.; Research Institute for Diseases of Old Ages, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
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Źródło:
Biomolecules [Biomolecules] 2023 Mar 15; Vol. 13 (3). Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Asthmatic Agents*/therapeutic use
Asthma*/drug therapy
Humans ; Quality of Life ; Th17 Cells ; Disease Progression ; Adrenal Cortex Hormones/therapeutic use ; Double-Blind Method
Czasopismo naukowe
Tytuł:
Itraconazole Improved Bronchial Wall Thickness in Severe Persistent Asthma: A Double-blind Placebo-controlled Randomized Clinical Trial.
Autorzy:
Aligolighasemabadi F; Department of Internal Medicine, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran AND Health Policy Research Centre, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran. .
Mirsadraee M; 3 Department of Internal Medicine, Medical School, Islamic Azad University, Mashhad Branch, Mashhad, Iran. .
Sadeghdoust M; Department of Internal Medicine, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran AND Health Policy Research Centre, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran. .
Ghaffari S; Department of Physiology, Faculty of Biology, Islamic Azad University, Damghan Branch, Damghan, Iran. .
Sarafraz Yazdi M; Department of Internal Medicine, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran. .
Naghibi S; Department of Radiology, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran. .
Hashemi Attar A; Department of Radiology, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran. .
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Źródło:
Iranian journal of allergy, asthma, and immunology [Iran J Allergy Asthma Immunol] 2023 Feb 20; Vol. 22 (1), pp. 1-11. Date of Electronic Publication: 2023 Feb 20.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Itraconazole*/therapeutic use
Asthma*/diagnosis
Asthma*/drug therapy
Humans ; Respiratory Sounds ; Bronchi/diagnostic imaging ; Prednisolone/therapeutic use ; Dyspnea/drug therapy ; Double-Blind Method ; Forced Expiratory Volume
Czasopismo naukowe
Tytuł:
Efficacy and safety of GSK3772847 in participants with moderate-to-severe asthma with allergic fungal airway disease: A phase IIa randomized, multicenter, double-blind, sponsor-open, comparative trial.
Autorzy:
Akinseye C; Medicines Research Centre, GSK, Stevenage, Hertfordshire, United Kingdom.
Crim C; Clinical Sciences-Respiratory, GSK, Research Triangle Park, North Carolina, United States of America.
Newlands A; Respiratory Medicines Development Centre, GSK, Brentford, Middlesex, United Kingdom.
Fairman D; Clinical Pharmacology Modelling and Simulation, GSK, Stevenage, Hertfordshire, United Kingdom.
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Źródło:
PloS one [PLoS One] 2023 Feb 03; Vol. 18 (2), pp. e0281205. Date of Electronic Publication: 2023 Feb 03 (Print Publication: 2023).
Typ publikacji:
Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Asthma*/drug therapy
Respiration Disorders*/drug therapy
Humans ; Adrenal Cortex Hormones/therapeutic use ; Double-Blind Method ; Prospective Studies ; Treatment Outcome ; Adolescent ; Adult
Czasopismo naukowe
Tytuł:
Effects of oligo-fucoidan on the immune response, inflammatory status and pulmonary function in patients with asthma: a randomized, double-blind, placebo-controlled trial.
Autorzy:
Yeh CW; Master Program of Biomedical Nutrition Program, Department of Nutrition, Hungkuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung, 43302, Taiwan, ROC.
Shih CJ; Master Program of Biomedical Nutrition Program, Department of Nutrition, Hungkuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung, 43302, Taiwan, ROC.
Liu TC; Department of Chest Medicine, Cheng-Ching General Hospital, Taichung, Taiwan, ROC. .
Chiou YL; Master Program of Biomedical Nutrition Program, Department of Nutrition, Hungkuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung, 43302, Taiwan, ROC. .
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Źródło:
Scientific reports [Sci Rep] 2022 Oct 28; Vol. 12 (1), pp. 18150. Date of Electronic Publication: 2022 Oct 28.
Typ publikacji:
Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Asthma*
Humans ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Lung ; Double-Blind Method ; Immunity
Czasopismo naukowe
Tytuł:
Nebulized budesonide combined with systemic corticosteroid vs systemic corticosteroid alone in acute severe asthma managed in the emergency department: a randomized controlled trial.
Autorzy:
Marghli S; Faculty of Medicine of Monastir, University of Monastir, 5019, Monastir, Tunisia. .; Emergency Department, Research Unit «Douleur thoracique», UR17SP09, Tahar Sfar University Hospital, 5100, Mahdia, Tunisia. .
Bouhamed C; Emergency Department, Research Unit «Douleur thoracique», UR17SP09, Tahar Sfar University Hospital, 5100, Mahdia, Tunisia.; Faculty of Medicine of Sousse, University of Sousse, 4002, Sousse, Tunisia.
Sghaier A; Faculty of Medicine of Monastir, University of Monastir, 5019, Monastir, Tunisia.; Emergency Department, Research Unit «Douleur thoracique», UR17SP09, Tahar Sfar University Hospital, 5100, Mahdia, Tunisia.
Chebbi N; Emergency Department, Research Unit «Douleur thoracique», UR17SP09, Tahar Sfar University Hospital, 5100, Mahdia, Tunisia.
Dlala I; Faculty of Medicine of Monastir, University of Monastir, 5019, Monastir, Tunisia.; Emergency Department, Research Unit «Douleur thoracique», UR17SP09, Tahar Sfar University Hospital, 5100, Mahdia, Tunisia.
Bettout S; Faculty of Medicine of Monastir, University of Monastir, 5019, Monastir, Tunisia.; Emergency Department, Research Unit «Douleur thoracique», UR17SP09, Tahar Sfar University Hospital, 5100, Mahdia, Tunisia.
Belkacem A; Emergency Department, Research Unit «Douleur thoracique», UR17SP09, Tahar Sfar University Hospital, 5100, Mahdia, Tunisia.
Kbaier S; Emergency Department, Research Unit «Douleur thoracique», UR17SP09, Tahar Sfar University Hospital, 5100, Mahdia, Tunisia.
Jerbi N; Faculty of Medicine of Monastir, University of Monastir, 5019, Monastir, Tunisia.; Emergency Department, Research Unit «Douleur thoracique», UR17SP09, Tahar Sfar University Hospital, 5100, Mahdia, Tunisia.
Bellou A; Institute of Sciences in Emergency Medicine, Department of Emergency Medicine, Guangdong provincial people's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, People's Republic of China.; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
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Źródło:
BMC emergency medicine [BMC Emerg Med] 2022 Jul 23; Vol. 22 (1), pp. 134. Date of Electronic Publication: 2022 Jul 23.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Asthma*/drug therapy
Budesonide*
Administration, Inhalation ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Double-Blind Method ; Emergency Service, Hospital ; Humans ; Prospective Studies
Czasopismo naukowe
Tytuł:
Mepolizumab improves work productivity, activity limitation, symptoms, and rescue medication use in severe eosinophilic asthma.
Autorzy:
Albers FC; Respiratory Medical Franchise, GSK, Raleigh, North Carolina, USA.
Bratton DJ; Clinical Statistics, GSK, Uxbridge, UK.
Gunsoy NB; Value Evidence and Outcomes, GSK, Uxbridge, UK.
Cockle SM; Value Evidence and Outcomes, GSK, Brentford, UK.
Alfonso-Cristancho R; Value Evidence and Outcomes, GSK, Philadelphia, Pennsylvania, USA.
Braunstahl GJ; Department of Pulmonary Medicine, Franciscus Gasthuis and Vlietland, Rotterdam, The Netherlands.
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Źródło:
The clinical respiratory journal [Clin Respir J] 2022 Mar; Vol. 16 (3), pp. 252-258. Date of Electronic Publication: 2022 Jan 26.
Typ publikacji:
Journal Article; Meta-Analysis
MeSH Terms:
Anti-Asthmatic Agents*/therapeutic use
Asthma*/diagnosis
Antibodies, Monoclonal, Humanized/therapeutic use ; Double-Blind Method ; Humans ; Randomized Controlled Trials as Topic ; Severity of Illness Index ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Dose-dependent inactivation of airway tryptase with a novel dissociating anti-tryptase antibody (MTPS9579A) in healthy participants: A randomized trial.
Autorzy:
Rymut SM; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Sukumaran S; Department of Preclinical and Translational PKPD, Genentech, Inc., South San Francisco, California, USA.
Sperinde G; Department of BioAnalytical Sciences, Genentech, Inc., South San Francisco, California, USA.
Bremer M; Department of Ophthalmology, Metabolism, Neurology, and Immunology Biomarker Development (OMNI-BD), Genentech, Inc., South San Francisco, California, USA.
Galanter J; Department of Safety Science, Genentech, Inc., South San Francisco, California, USA.
Yoshida K; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Smith J; Department of Biostatistics, F. Hoffmann-La Roche, Mississauga, Ontario, Canada.
Banerjee P; Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, USA.
Sverkos V; Department of BioAnalytical Sciences, Genentech, Inc., South San Francisco, California, USA.
Cai F; Department of Ophthalmology, Metabolism, Neurology, and Immunology Biomarker Development (OMNI-BD), Genentech, Inc., South San Francisco, California, USA.
Steffen V; Department of Biostatistics, Genentech, Inc., South San Francisco, California, USA.
Henderson LM; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Rhee H; Early Clinical Development, Ophthalmology, Metabolism, Neurology, and Immunology (OMNI), Genentech, Inc., South San Francisco, California, USA.
Belloni PN; Early Clinical Development, Ophthalmology, Metabolism, Neurology, and Immunology (OMNI), Genentech, Inc., South San Francisco, California, USA.
Lin JH; Early Clinical Development, Ophthalmology, Metabolism, Neurology, and Immunology (OMNI), Genentech, Inc., South San Francisco, California, USA.
Staton TL; Department of Ophthalmology, Metabolism, Neurology, and Immunology Biomarker Development (OMNI-BD), Genentech, Inc., South San Francisco, California, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2022 Feb; Vol. 15 (2), pp. 451-463. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Asthma*/drug therapy
Area Under Curve ; Dose-Response Relationship, Drug ; Double-Blind Method ; Healthy Volunteers ; Humans ; Tryptases/therapeutic use
Czasopismo naukowe
Tytuł:
Pharmacokinetics and pharmacodynamics of itepekimab in healthy adults and patients with asthma: Phase I first-in-human and first-in-patient trials.
Autorzy:
Kosloski MP; Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Kalliolias GD; Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Xu CR; Sanofi, Bridgewater, New Jersey, USA.
Harel S; Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Lai CH; Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Zheng W; Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Davis JD; Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Kamal MA; Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2022 Feb; Vol. 15 (2), pp. 384-395. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Asthma*/chemically induced
Asthma*/drug therapy
Administration, Intravenous ; Adult ; Antibodies, Monoclonal/pharmacokinetics ; Antibodies, Monoclonal, Humanized ; Dose-Response Relationship, Drug ; Double-Blind Method ; Healthy Volunteers ; Humans
Czasopismo naukowe
Tytuł:
The Probiotics in Pediatric Asthma Management (PROPAM) Study in the Primary Care Setting: A Randomized, Controlled, Double-Blind Trial with Ligilactobacillus salivarius LS01 (DSM 22775) and Bifidobacterium breve B632 (DSM 24706).
Autorzy:
Drago L; Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Cioffi L; Pediatric Primary Care ASL Napoli 2, Naples, Italy.
Giuliano M; Pediatric Primary Care ASL Napoli 2, Naples, Italy.
Pane M; Research and Development, Probiotical Research, Novara, Italy.
Amoruso A; Research and Development, Probiotical Research, Novara, Italy.
Schiavetti I; Health Science Department, University of Genoa, Genoa, Italy.
Reid G; Departments of Microbiology, Immunology and Surgery, Western University, London, ON, Canada.
Ciprandi G; Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.
Propam Study Group; Pediatric Primary Care ASL Napoli 2, Naples, Italy.
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Źródło:
Journal of immunology research [J Immunol Res] 2022 Jan 17; Vol. 2022, pp. 3837418. Date of Electronic Publication: 2022 Jan 17 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Asthma/*therapy
Bifidobacterium breve/*physiology
Child ; Child, Preschool ; Double-Blind Method ; Dysbiosis ; Female ; Humans ; Italy ; Male ; Primary Health Care ; Probiotics ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Long-term safety and exploratory efficacy of fevipiprant in patients with inadequately controlled asthma: the SPIRIT randomised clinical trial.
Autorzy:
Maspero J; Allergy and Respiratory Research Unit, Fundación CIDEA, Buenos Aires, Argentina. .
Agache IO; Transylvania University, Brasov, Romania.
Kamei T; Kamei Internal Medicine and Respiratory Clinic, Takamatsu-city, Kagawa, Japan.
Yoshida M; National Hospital Organization Fukuoka National Hospital, Fukuoka-city, Fukuoka, Japan.
Boone B; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
Felser JM; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
Kawakami F; Novartis Pharma AG, Basel, Switzerland.
Knorr B; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
Lawrence D; Novartis Pharma AG, Basel, Switzerland.
Lehmann T; Novartis Pharma AG, Basel, Switzerland.
Wang W; Novartis Institutes for Biomedical Research Co., Ltd, Shanghai, China.
Pedinoff AJ; Princeton Center for Clinical Research, Skillman, NJ, USA.
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Źródło:
Respiratory research [Respir Res] 2021 Dec 11; Vol. 22 (1), pp. 311. Date of Electronic Publication: 2021 Dec 11.
Typ publikacji:
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms:
Asthma/*drug therapy
Forced Expiratory Volume/*drug effects
Indoleacetic Acids/*administration & dosage
Pyridines/*administration & dosage
Administration, Inhalation ; Asthma/physiopathology ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Short- and long-term effects of fluticasone furoate/vilanterol in exercising asthmatic adolescents: A randomized and open label trial.
Autorzy:
Bar-Yoseph R; Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel.; Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Gur M; Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel.; Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Zuckerman S; Department of Pediatrics, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Gut G; Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Hanna M; Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Toukan Y; Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel.; Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Nir V; Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel.; Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Masarweh K; Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Bentur L; Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel.; Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2021 Nov; Vol. 129 (5), pp. 369-375. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji:
Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms:
Albuterol/*administration & dosage
Androstadienes/*administration & dosage
Asthma/*drug therapy
Benzyl Alcohols/*administration & dosage
Bronchodilator Agents/*administration & dosage
Chlorobenzenes/*administration & dosage
Administration, Inhalation ; Adolescent ; Albuterol/pharmacology ; Androstadienes/pharmacology ; Asthma/physiopathology ; Benzyl Alcohols/pharmacology ; Bronchodilator Agents/pharmacology ; Child ; Chlorobenzenes/pharmacology ; Double-Blind Method ; Drug Combinations ; Exercise Test ; Female ; Forced Expiratory Volume/drug effects ; Humans ; Male ; Nebulizers and Vaporizers ; Prospective Studies ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Population repeated time-to-event analysis of exacerbations in asthma patients: A novel approach for predicting asthma exacerbations based on biomarkers, spirometry, and diaries/questionnaires.
Autorzy:
Svensson RJ; Pharmetheus, Uppsala, Sweden.
Ribbing J; Pharmetheus, Uppsala, Sweden.
Kotani N; Genentech, South San Francisco, California, USA.; Chugai Pharmaceutical, Tokyo, Japan.
Dolton M; Genentech, South San Francisco, California, USA.
Vadhavkar S; Genentech, South San Francisco, California, USA.
Cheung D; Genentech, South San Francisco, California, USA.
Staton T; Genentech, South San Francisco, California, USA.
Choy DF; Genentech, South San Francisco, California, USA.
Putnam W; Genentech, South San Francisco, California, USA.
Jin J; Genentech, South San Francisco, California, USA.
Budha N; Genentech, South San Francisco, California, USA.
Karlsson MO; Pharmetheus, Uppsala, Sweden.; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Quartino A; Genentech, South San Francisco, California, USA.
Zhu R; Genentech, South San Francisco, California, USA.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 Oct; Vol. 10 (10), pp. 1221-1235. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Inflammatory Agents/*therapeutic use
Antibodies, Monoclonal, Humanized/*therapeutic use
Asthma/*drug therapy
Adult ; Asthma/physiopathology ; Biomarkers ; Disease Progression ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Progression-Free Survival ; Proportional Hazards Models ; Severity of Illness Index ; Spirometry ; Surveys and Questionnaires ; Time Factors
Czasopismo naukowe
Tytuł:
Limosilactobacillus reuteri DSM-17938 for preventing cough in adults with mild allergic asthma: A double-blind randomized placebo-controlled cross-over study.
Autorzy:
Satia I; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.; Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, ON, Canada.
Cusack R; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Stevens C; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Schlatman A; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Wattie J; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Mian F; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Killian KJ; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
O'Byrne PM; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.; Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, ON, Canada.
Bienenstock J; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Forsythe P; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Gauvreau GM; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
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Źródło:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2021 Sep; Vol. 51 (9), pp. 1133-1143. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Limosilactobacillus reuteri*
Asthma/*complications
Cough/*etiology
Cough/*prevention & control
Probiotics/*therapeutic use
Adult ; Cross-Over Studies ; Double-Blind Method ; Female ; Humans ; Male ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Bacterial lysate add-on therapy to reduce exacerbations in severe asthma: A double-blind placebo-controlled trial.
Autorzy:
de Boer GM; Department of Pulmonary Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.; Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Braunstahl GJ; Department of Pulmonary Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.; Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
van der Ploeg EK; Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands.
van Zelst CM; Department of Pulmonary Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.; Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
van Bruggen A; Department of Pulmonary Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
Epping G; Department of Pulmonary Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
van Nimwegen M; Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Verhoeven G; Department of Pulmonary Medicine, Maasstad hospital, Rotterdam, The Netherlands.
Birnie E; Department of Scientific Education, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
Boxma-de Klerk BM; Department of Scientific Education, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
de Bruijn MJW; Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Stadhouders R; Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hendriks RW; Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Tramper-Stranders GA; Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Pediatrics, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
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Źródło:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2021 Sep; Vol. 51 (9), pp. 1172-1184. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Adjuvants, Immunologic/*therapeutic use
Asthma/*drug therapy
Asthma/*immunology
Cell Extracts/*therapeutic use
Adolescent ; Adult ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Young Adult
Czasopismo naukowe
Tytuł:
Bronchodilating effects of a new beclometasone dipropionate plus formoterol fumarate formulation via pressurized metered-dose inhaler in asthmatic children: a double-blind, randomized, cross-over clinical study.
Autorzy:
Pohunek P; Paediatric Department, University Hospital Motol, V Uvalu 84, 150 06, Praha, Czech Republic. .
Varoli G; Global Clinical Development, Chiesi Farmaceutici S.p.A., Via Palermo 26/A, 43122, Parma, Italy.
Reznichenko Y; Pulmonology Department of Community Institution 'Zaporizhzhya Regional Clinical Child Hospital' of Zaporizhzhya Regional Council, Zaporizhzhya State Medical University, 70 Lenina str, Zaporizhzhya, 69063, Ukraine.
Mokia-Serbina S; City Clinical Hospital № 8, 55, 23rd Lyutogo str., Kryvyi Rog, Ukraine.
Brzostek J; Poradnia Alergologiczna, ZOZ Debica, ul., Krakowska 91, 39-200, Debica, Poland.
Kostromina V; Department of Child Pulmonology and Allergology, State Institution 'National Institute of Physiatry and Pulmonology n.a. F.G. Yanovskyy of AMS of Ukraine', 10, Amosova str., Kyiv, 03680, Ukraine.
Kaladze M; 1st City Children Clinical Association of Simferopol City, Department of Pulmonology, Simferopol, Department of Pediatry with Physiotherapy Course of Faculty of Postgraduate Education, State Institution 'Crimean State Medical University n.a. S.I. Georgiyivskiy', 31, K. Libknehta, Simferopol, Crimea, Russia.
Muraro A; Global Clinical Development, Chiesi Farmaceutici S.p.A., Via Palermo 26/A, 43122, Parma, Italy.
Carzana E; Global Clinical Development, Chiesi Farmaceutici S.p.A., Via Palermo 26/A, 43122, Parma, Italy.
Armani S; Global Clinical Development, Chiesi Farmaceutici S.p.A., Via Palermo 26/A, 43122, Parma, Italy.
Kaczmarek J; Outpatient Clinic of Allergology, Kopcinskiego Str 22, 90-153, Lodz, Poland.
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Źródło:
European journal of pediatrics [Eur J Pediatr] 2021 May; Vol. 180 (5), pp. 1467-1475. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Anti-Asthmatic Agents*/pharmacology
Asthma*/drug therapy
Administration, Inhalation ; Beclomethasone/pharmacology ; Beclomethasone/therapeutic use ; Bronchodilator Agents/therapeutic use ; Child ; Cross-Over Studies ; Double-Blind Method ; Drug Combinations ; Forced Expiratory Volume ; Formoterol Fumarate/pharmacology ; Formoterol Fumarate/therapeutic use ; Humans ; Italy ; Metered Dose Inhalers ; Nebulizers and Vaporizers ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Efficacy of vitamin D supplementation in asthmatic children with vitamin D deficiency: A randomized controlled trial (ESDAC trial).
Autorzy:
Jat KR; Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Goel N; Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Gupta N; Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India.
Gupta CP; Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Datta S; Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India.
Lodha R; Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Kabra SK; Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
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Źródło:
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [Pediatr Allergy Immunol] 2021 Apr; Vol. 32 (3), pp. 479-488. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Asthma*/drug therapy
Vitamin D Deficiency*/complications
Vitamin D Deficiency*/drug therapy
Child ; Cholecalciferol ; Dietary Supplements ; Double-Blind Method ; Humans ; Infant, Newborn ; Male ; Vitamin D
Czasopismo naukowe

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