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Wyszukujesz frazę ""Down-Regulation"" wg kryterium: Temat


Tytuł :
Docosahexaenoic acid (DHA) inhibits pro-angiogenic effects of breast cancer cells via down-regulating cellular and exosomal expression of angiogenic genes and microRNAs.
Autorzy :
Aslan C; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Maralbashi S; Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Kahroba H; Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Asadi M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Soltani-Zangbar MS; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Javadian M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Shanehbandi D; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Darabi M; Biochemistry & Clinical Laboratories, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Kazemi T; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118094. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*/drug effects
Down-Regulation*/genetics
Breast Neoplasms/*blood supply
Breast Neoplasms/*genetics
Docosahexaenoic Acids/*pharmacology
Exosomes/*genetics
MicroRNAs/*genetics
Neovascularization, Pathologic/*genetics
Breast Neoplasms/drug therapy ; Breast Neoplasms/ultrastructure ; Cell Line, Tumor ; Exosomes/drug effects ; Exosomes/ultrastructure ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MicroRNAs/metabolism
Czasopismo naukowe
Tytuł :
miR-324-5p inhibits gallbladder carcinoma cell metastatic behaviours by downregulation of transforming growth factor beta 2 expression.
Autorzy :
Zhang X; Department of Digestive Medicine, Tianjin Nankai Hospital, Tianjin, People's Republic of China.
Zhang L; Department of Traditional Chinese Medicine, Geriatric Hospital, Civil Affairs Bureau of Tianjin, Tianjin, People's Republic of China.
Chen M; Department of Liver Tumor Internal Medicine, Tianjin Nankai Hospital, Tianjin, People's Republic of China.
Liu D; Department of Integrated Traditional Chinese and Western Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 315-324.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Down-Regulation*
Gene Expression Regulation, Neoplastic*
Gallbladder Neoplasms/*metabolism
MicroRNAs/*metabolism
Neoplasm Proteins/*biosynthesis
RNA, Neoplasm/*metabolism
Transforming Growth Factor beta2/*biosynthesis
Cell Line, Tumor ; Gallbladder Neoplasms/genetics ; Gallbladder Neoplasms/pathology ; Humans ; MicroRNAs/genetics ; Neoplasm Metastasis ; Neoplasm Proteins/genetics ; RNA, Neoplasm/genetics ; Transforming Growth Factor beta2/genetics
Czasopismo naukowe
Tytuł :
Protocatechuic aldehyde mitigates hydrogen peroxide-triggered PC12 cell damage by down-regulating MEG3.
Autorzy :
Zhong Z; Department of Pain, China-Japan Union Hospital of Jilin University, Jilin, China.
Yao X; Department of Pathology, Changchun Medical College, Jilin, China.
Luo M; Department of Pain, China-Japan Union Hospital of Jilin University, Jilin, China.
Li M; Department of Medical Insurance Management, China-Japan Union Hospital of Jilin University, Jilin, China.
Dong L; Department of Pain, China-Japan Union Hospital of Jilin University, Jilin, China.
Zhang Z; Department of Orthopedics, The Second Hospital of Jilin University, Jilin, China.
Jiang R; Department of Orthopedics, China-Japan Union Hospital of Jilin University, Jilin, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 602-609.
Typ publikacji :
Journal Article
MeSH Terms :
Benzaldehydes/*pharmacology
Catechols/*pharmacology
Down-Regulation/*drug effects
Hydrogen Peroxide/*toxicity
RNA, Long Noncoding/*genetics
Animals ; Apoptosis/drug effects ; Autophagy/drug effects ; Cell Survival/drug effects ; Down-Regulation/genetics ; PC12 Cells ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Signal Transduction/drug effects ; Wnt Proteins/metabolism ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Autorzy :
Roberts BM; Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK. .; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK. .
Doig NM; Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX1 3TH, UK.
Brimblecombe KR; Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.
Lopes EF; Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Siddorn RE; Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Threlfell S; Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.
Connor-Robson N; Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.
Bengoa-Vergniory N; Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.
Pasternack N; Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Wade-Martins R; Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.
Magill PJ; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.; Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX1 3TH, UK.
Cragg SJ; Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK. .; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 02; Vol. 11 (1), pp. 4958. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Corpus Striatum/*metabolism
Dopamine/*metabolism
GABA Plasma Membrane Transport Proteins/*metabolism
Parkinsonian Disorders/*metabolism
gamma-Aminobutyric Acid/*metabolism
Animals ; Astrocytes/metabolism ; Cell Membrane/metabolism ; Disease Models, Animal ; Glutamate Decarboxylase/metabolism ; Mice, Inbred C57BL ; Models, Biological ; Nucleus Accumbens/metabolism
Czasopismo naukowe
Tytuł :
3β-Hydroxycholest-5-en-7-one from seahorse alleviates lipopolysaccharide-induced inflammatory responses by downregulating miR-98-5p.
Autorzy :
Wu J; Xiamen Key Laboratory of Marine Medicinal Natural Products Resources, Xiamen Medical College, Xiamen 361023, PR China; Fujian Universities and Colleges Engineering Research Center of Marine Biopharmaceutical Resources, Xiamen Medical College, Xiamen 361023, PR China. Electronic address: .
Chen X; Fisheries Research Institute of Fujian, Xiamen 361013, PR China.
Pan N; Fisheries Research Institute of Fujian, Xiamen 361013, PR China.
Chen B; Fisheries Research Institute of Fujian, Xiamen 361013, PR China.
Zhang J; Xiamen Key Laboratory of Marine Medicinal Natural Products Resources, Xiamen Medical College, Xiamen 361023, PR China; Fujian Universities and Colleges Engineering Research Center of Marine Biopharmaceutical Resources, Xiamen Medical College, Xiamen 361023, PR China.
Liu Z; Fisheries Research Institute of Fujian, Xiamen 361013, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118176. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji :
Journal Article
MeSH Terms :
Cholestenones/*pharmacology
Down-Regulation/*genetics
Inflammation/*pathology
MicroRNAs/*metabolism
Smegmamorpha/*metabolism
3' Untranslated Regions/genetics ; Animals ; Cholestenones/chemistry ; Down-Regulation/drug effects ; Genes, Reporter ; Inflammation/genetics ; Lentivirus/metabolism ; Lipopolysaccharides ; Luciferases/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; MicroRNAs/genetics ; RAW 264.7 Cells ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
PADI4 modulates the invasion and migration of osteosarcoma cells by down-regulation of epithelial-mesenchymal transition.
Autorzy :
Zhai Q; Center of Translational Medicine, Zibo Central Hospital, Zibo 255036, China.
Qin J; Department of Oncology, Gaoqing People's Hospital, Zibo 256300, China.
Jin X; Department of Geriatrics, Zibo Central Hospital, Zibo 255036, China.
Sun X; Department of Pathology, Zibo Central Hospital, Zibo 255036, China.
Wang L; Center of Translational Medicine, Zibo Central Hospital, Zibo 255036, China.
Du W; Center of Translational Medicine, Zibo Central Hospital, Zibo 255036, China.
Li T; Center of Translational Medicine, Zibo Central Hospital, Zibo 255036, China. Electronic address: .
Xiang X; Center of Translational Medicine, Zibo Central Hospital, Zibo 255036, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 01; Vol. 256, pp. 117968. Date of Electronic Publication: 2020 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
Down-Regulation*/genetics
Epithelial-Mesenchymal Transition*/genetics
Osteosarcoma/*enzymology
Osteosarcoma/*pathology
Protein-Arginine Deiminase Type 4/*metabolism
Antigens, CD/metabolism ; Cadherins/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/secondary ; Neoplasm Invasiveness ; Osteosarcoma/genetics ; Protein-Arginine Deiminase Type 4/genetics
Czasopismo naukowe
Tytuł :
A novel gene in early childhood diabetes: EDEM2 silencing decreases SLC2A2 and PXD1 expression, leading to impaired insulin secretion.
Autorzy :
Alhaidan Y; Department of Clinical Genetics, Odense University Hospital, J.B. Windsløws Vej 4, 5000, Odense, Denmark. .; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5000, Odense C, Denmark. .; Department of Medical Genomics Research, King Abdullah International Medical Research Center, Riyadh, 11426, Saudi Arabia. .; King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. .
Christesen HT; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5000, Odense C, Denmark.; Hans Christian Andersen Children's Hospital, Odense University Hospital, 5000, Odense C, Denmark.; Odense Pancreases Center, Odense C, Denmark.
Højlund K; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5000, Odense C, Denmark.; Steno Diabetes Center Odense, Odense University Hospital, 5000, Odense, Denmark.
Al Balwi MA; Department of Medical Genomics Research, King Abdullah International Medical Research Center, Riyadh, 11426, Saudi Arabia.; King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Brusgaard K; Department of Clinical Genetics, Odense University Hospital, J.B. Windsløws Vej 4, 5000, Odense, Denmark.; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5000, Odense C, Denmark.; Near East University, Nicosia, Cyprus.
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Źródło :
Molecular genetics and genomics : MGG [Mol Genet Genomics] 2020 Sep; Vol. 295 (5), pp. 1253-1262. Date of Electronic Publication: 2020 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Point Mutation*
Diabetes Mellitus/*genetics
Glucose Transporter Type 2/*genetics
Glycoproteins/*genetics
Homeodomain Proteins/*genetics
Trans-Activators/*genetics
alpha-Mannosidase/*genetics
Age of Onset ; Aged ; Animals ; Cell Line ; Diabetes Mellitus/metabolism ; European Continental Ancestry Group/genetics ; Female ; Gene Silencing ; Humans ; Insulin/genetics ; Insulin/metabolism ; Male ; Middle Aged ; Pedigree ; Rats ; Whole Exome Sequencing ; Young Adult
Czasopismo naukowe
Tytuł :
Effect of Phosphoribosyltransferase Down-regulation on Malignant Glioma Cell Characteristics.
Autorzy :
Kamada M; Division of Molecular Genetics, Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan .; Division of Molecular Cell Biology, Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
Ikeda K; Division of Molecular Cell Biology, Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
Manome Y; Division of Molecular Cell Biology, Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2020 Sep; Vol. 40 (9), pp. 4895-4905.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Cytokines/*metabolism
Glioma/*enzymology
Nicotinamide Phosphoribosyltransferase/*metabolism
Antineoplastic Agents, Alkylating/pharmacology ; Cell Line, Tumor ; Cell Proliferation ; Cytokines/genetics ; Glioma/metabolism ; Glioma/pathology ; Humans ; NAD/metabolism ; Nicotinamide Phosphoribosyltransferase/genetics ; Pentosyltransferases/genetics ; Pentosyltransferases/metabolism ; RNA, Small Interfering/genetics ; Temozolomide/pharmacology
Czasopismo naukowe
Tytuł :
Overlapping and distinct roles of CDPK family members in the pre-erythrocytic stages of the rodent malaria parasite, Plasmodium berghei.
Autorzy :
Govindasamy K; Rutgers New Jersey Medical School, Department of Microbiology, Biochemistry and Molecular Genetics, Newark, New Jersey, United States of America.
Bhanot P; Rutgers New Jersey Medical School, Department of Microbiology, Biochemistry and Molecular Genetics, Newark, New Jersey, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Aug 31; Vol. 16 (8), pp. e1008131. Date of Electronic Publication: 2020 Aug 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Down-Regulation*
Gene Expression Regulation, Enzymologic*
Malaria/*epidemiology
Merozoites/*enzymology
Plasmodium berghei/*enzymology
Protein Kinases/*biosynthesis
Protozoan Proteins/*biosynthesis
Sporozoites/*enzymology
Animals ; Erythrocytes/enzymology ; Erythrocytes/parasitology ; Female ; Hep G2 Cells ; Humans ; Liver/enzymology ; Liver/parasitology ; Malaria/pathology ; Mice
Czasopismo naukowe
Tytuł :
Knockdown of Tcirg1 inhibits large-osteoclast generation by down-regulating NFATc1 and IP3R2 expression.
Autorzy :
Zhang D; Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Shandong University & Shandong Provincial Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong, PR China.; Department of Stomatology & Key Laboratory of Oral Maxillofacial-Head and Neck Medical Biology of Shandong Province & Precision Biomedical Key Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong, PR China.
Lin L; Department of Stomatology & Key Laboratory of Oral Maxillofacial-Head and Neck Medical Biology of Shandong Province & Precision Biomedical Key Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong, PR China.
Yang B; Department of Stomatology & Key Laboratory of Oral Maxillofacial-Head and Neck Medical Biology of Shandong Province & Precision Biomedical Key Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong, PR China.
Meng Z; Department of Stomatology & Key Laboratory of Oral Maxillofacial-Head and Neck Medical Biology of Shandong Province & Precision Biomedical Key Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong, PR China.
Zhang B; Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Shandong University & Shandong Provincial Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong, PR China.; Department of Stomatology & Key Laboratory of Oral Maxillofacial-Head and Neck Medical Biology of Shandong Province & Precision Biomedical Key Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong, PR China.
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Źródło :
PloS one [PLoS One] 2020 Aug 13; Vol. 15 (8), pp. e0237354. Date of Electronic Publication: 2020 Aug 13 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Osteogenesis*
Inositol 1,4,5-Trisphosphate Receptors/*genetics
NFATC Transcription Factors/*genetics
Vacuolar Proton-Translocating ATPases/*genetics
Animals ; Cells, Cultured ; Gene Knockdown Techniques ; Male ; Mice ; Osteoclasts/cytology ; Osteoclasts/metabolism
Czasopismo naukowe
Tytuł :
Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55 to the Plasma Membrane.
Autorzy :
Gonzales B; INSERM U1259, University of Tours, Tours, France.
de Rocquigny H; INSERM U1259, University of Tours, Tours, France.
Beziau A; INSERM U1259, University of Tours, Tours, France.
Durand S; INSERM U1259, University of Tours, Tours, France.
Burlaud-Gaillard J; INSERM U1259, University of Tours, Tours, France.
Lefebvre A; INSERM U1253, University of Tours, Tours, France.
Krull S; Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Emond P; INSERM U1253, University of Tours, Tours, France.
Brand D; INSERM U1259, University of Tours, Tours, France.; Laboratoire de Virologie, Tours University Hospital, Tours, France.
Piver E; INSERM U1259, University of Tours, Tours, France .; Biochimie et Biologie Moléculaire, Tours University Hospital, Tours, France.
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Źródło :
Journal of virology [J Virol] 2020 Jul 01; Vol. 94 (14). Date of Electronic Publication: 2020 Jul 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Gene Expression Regulation, Enzymologic*
Cell Membrane/*metabolism
HIV-1/*metabolism
Phosphotransferases (Alcohol Group Acceptor)/*biosynthesis
Protein Precursors/*metabolism
Cell Membrane/genetics ; Cell Membrane/virology ; Endosomes/genetics ; Endosomes/metabolism ; Endosomes/virology ; HIV-1/genetics ; HeLa Cells ; Humans ; Lysosomes/genetics ; Lysosomes/metabolism ; Lysosomes/virology ; Phosphatidylinositol 4,5-Diphosphate/genetics ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Proteasome Endopeptidase Complex/genetics ; Proteasome Endopeptidase Complex/metabolism ; Protein Precursors/genetics ; Proteolysis
Czasopismo naukowe
Tytuł :
Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes.
Autorzy :
Umviligihozo G; Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.
Cobarrubias KD; Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.
Chandrarathna S; Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.
Jin SW; Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.
Reddy N; University of KwaZulu-Natal, Durban, South Africa.; Africa Health Research Institute, Durban, South Africa.
Byakwaga H; Mbarara University of Science and Technology, Mbarara, Uganda.; University of California, San Francisco, California, USA.
Muzoora C; Mbarara University of Science and Technology, Mbarara, Uganda.
Bwana MB; Mbarara University of Science and Technology, Mbarara, Uganda.
Lee GQ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Hunt PW; University of California, San Francisco, California, USA.
Martin JN; University of California, San Francisco, California, USA.
Brumme CJ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; University of British Columbia, Vancouver, British Columbia, Canada.
Bangsberg DR; Oregon Health and Science University-Portland State University School of Public Health, Portland, Oregon, USA.
Karita E; Rwanda Zambia HIV Research Group-Projet San Francisco, Kigali, Rwanda.
Allen S; Rwanda Zambia HIV Research Group-Projet San Francisco, Kigali, Rwanda.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.; Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Hunter E; Rwanda Zambia HIV Research Group-Projet San Francisco, Kigali, Rwanda.; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Ndung'u T; University of KwaZulu-Natal, Durban, South Africa.; Africa Health Research Institute, Durban, South Africa.; Max Planck Institute for Infection Biology, Berlin, Germany.; Division of Infection and Immunity, University College London, London, United Kingdom.
Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Brockman MA; Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada .; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
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Źródło :
Journal of virology [J Virol] 2020 Jul 01; Vol. 94 (14). Date of Electronic Publication: 2020 Jul 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
HIV Infections*
Antigens, CD/*biosynthesis
CD4 Antigens/*biosynthesis
HIV-1/*metabolism
Human Immunodeficiency Virus Proteins/*metabolism
Viral Regulatory and Accessory Proteins/*metabolism
Antigens, CD/genetics ; CD4 Antigens/genetics ; Cell Line, Transformed ; Chronic Disease ; GPI-Linked Proteins/biosynthesis ; GPI-Linked Proteins/genetics ; HIV-1/genetics ; Human Immunodeficiency Virus Proteins/genetics ; Humans ; Viral Regulatory and Accessory Proteins/genetics
Czasopismo naukowe
Tytuł :
Hypoxia training improves hepatic steatosis partly by downregulation of CB1 receptor in obese mice.
Autorzy :
Yang Q; International College of Football Tongji University, No.1239 Siping Road, Yangpu District, Shanghai, China; School of Kinesiology, Shanghai University of Sport, No.650 Qingyuanhuan Road, Yangpu District, Shanghai, China.
Sun S; Jiangxi Institute of Sports Science, No.28 Fuzhou Road, Donghu District, Nanchang, Jiangxi Province, China.
Liu W; College of Physical Education, Guangxi University of Science and Technology, No. 268, Donghuan Road, Chengzhong District, Liuzhou, Guangxi Zhuang Autonomous Region, China.
Liu Q; International College of Football Tongji University, No.1239 Siping Road, Yangpu District, Shanghai, China.
Wang J; International College of Football Tongji University, No.1239 Siping Road, Yangpu District, Shanghai, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 May 07; Vol. 525 (3), pp. 639-645. Date of Electronic Publication: 2020 Feb 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*/drug effects
Down-Regulation*/genetics
Fatty Liver/*genetics
Fatty Liver/*pathology
Hypoxia/*pathology
Receptor, Cannabinoid, CB1/*metabolism
Animals ; Benzoxazines/pharmacology ; Endocannabinoids/metabolism ; Hypoxia/genetics ; Lipid Metabolism/drug effects ; Male ; Mice, Inbred C57BL ; Mice, Obese ; Morpholines/pharmacology ; Naphthalenes/pharmacology ; Phenotype ; Receptor, Cannabinoid, CB1/agonists
Czasopismo naukowe
Tytuł :
Use of Real-Time Functional Magnetic Resonance Imaging-Based Neurofeedback to Downregulate Insular Cortex in Nicotine-Addicted Smokers.
Autorzy :
Rana M; Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de Chile; Laboratory for Brain-Machine Interfaces and Neuromodulation, Pontificia Universidad Católica de Chile; .
Ruiz S; Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de Chile; Laboratory for Brain-Machine Interfaces and Neuromodulation, Pontificia Universidad Católica de Chile; .
Corzo AS; Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de Chile; Laboratory for Brain-Machine Interfaces and Neuromodulation, Pontificia Universidad Católica de Chile.
Muehleck A; Department of Psychiatry and Psychotherapy, University of Tübingen.
Eck S; Department of Psychiatry and Psychotherapy, University of Tübingen.
Salinas C; Unidad de Imágenes Cuantitativas Avanzadas, Departamento de Imaágenes, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo.
Zamorano F; Unidad de Imágenes Cuantitativas Avanzadas, Departamento de Imaágenes, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo; División de Neurociencia, Centro de Investigación en Complejidad Social (neuroCICS), Facultad de Gobierno, Universidad del Desarrollo.
Silva C; Unidad de Imágenes Cuantitativas Avanzadas, Departamento de Imaágenes, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo.
Rea M; Department of Psychiatry and Psychotherapy, University of Tübingen.
Batra A; Department of Psychiatry and Psychotherapy, University of Tübingen.
Birbaumer N; Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de Chile; Institute di Ricovero e Cura a Carattere Scientifico; Wyss Center for Bio and Neuroengineering.
Sitaram R; Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de Chile; Laboratory for Brain-Machine Interfaces and Neuromodulation, Pontificia Universidad Católica de Chile; Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2020 Jun 10 (160). Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Down-Regulation*
Magnetic Resonance Imaging*
Neurofeedback*
Smokers*
Cerebral Cortex/*diagnostic imaging
Nicotine/*adverse effects
Tobacco Use Disorder/*diagnostic imaging
Tobacco Use Disorder/*physiopathology
Cerebral Cortex/physiopathology ; Craving/physiology ; Follow-Up Studies ; Humans ; Oxygen/blood ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia.
Autorzy :
Rivellese F; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom. Electronic address: .
Prediletto E; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
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Źródło :
Autoimmunity reviews [Autoimmun Rev] 2020 Jun; Vol. 19 (6), pp. 102536. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji :
Letter
MeSH Terms :
Down-Regulation*/drug effects
Betacoronavirus/*pathogenicity
Coronavirus Infections/*pathology
Coronavirus Infections/*virology
Peptidyl-Dipeptidase A/*metabolism
Pneumonia, Viral/*pathology
Respiratory Distress Syndrome, Adult/*pathology
Air Pollution/statistics & numerical data ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; Alveolar Epithelial Cells/virology ; Betacoronavirus/metabolism ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Humans ; Lung Injury/pathology ; Lung Injury/virology ; Lymphohistiocytosis, Hemophagocytic/pathology ; Lymphohistiocytosis, Hemophagocytic/virology ; Macrophages/immunology ; Models, Biological ; Pandemics ; Peptidyl-Dipeptidase A/deficiency ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Receptors, Virus/deficiency ; Receptors, Virus/metabolism ; Respiratory Distress Syndrome, Adult/epidemiology ; Respiratory Distress Syndrome, Adult/immunology ; Respiratory Distress Syndrome, Adult/virology ; Stem Cells/pathology ; Stem Cells/virology ; Viral Load ; Virus Replication
SCR Disease Name :
COVID-19
Opinia redakcyjna
Tytuł :
Plasma miR-181a-5p Downregulation Predicts Response and Improved Survival After FOLFIRINOX in Pancreatic Ductal Adenocarcinoma.
Autorzy :
Meijer LL; Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, VU University Amsterdam, the Netherlands.
Garajová I; Department of Medical Oncology, Cancer Center Amsterdam, VU University Amsterdam, The Netherlands.; Department of Medical Oncology, University Hospital S. Orsola-Malpighi, Bologna, Italy.
Caparello C; Department of Medical Oncology, University Hospital of Pisa, Pisa, Italy.
Le Large TYS; Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, VU University Amsterdam, the Netherlands.; Department of Medical Oncology, Cancer Center Amsterdam, VU University Amsterdam, The Netherlands.; Laboratory of Experimental Oncology & Radiobiology, Academic Medical Center, Amsterdam, The Netherlands.
Frampton AE; HPB Surgical Unit, Department of Surgery & Cancer, Imperial College, London, United Kingdom.
Vasile E; Department of Medical Oncology, University Hospital of Pisa, Pisa, Italy.
Funel N; Cancer Pharmacology Lab, AIRC-Start-Up Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University Hospital of Pisa, Pisa, Italy.
Kazemier G; Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, VU University Amsterdam, the Netherlands.
Giovannetti E; Department of Medical Oncology, Cancer Center Amsterdam, VU University Amsterdam, The Netherlands.; Cancer Pharmacology Lab, AIRC-Start-Up Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University Hospital of Pisa, Pisa, Italy.
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Źródło :
Annals of surgery [Ann Surg] 2020 Jun; Vol. 271 (6), pp. 1137-1147.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Carcinoma, Pancreatic Ductal/*blood
MicroRNAs/*blood
Pancreatic Neoplasms/*blood
Adult ; Aged ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/blood ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/mortality ; Female ; Fluorouracil/therapeutic use ; Humans ; Immunohistochemistry ; Irinotecan/therapeutic use ; Leucovorin/therapeutic use ; Male ; MicroRNAs/genetics ; Middle Aged ; Netherlands/epidemiology ; Oxaliplatin/therapeutic use ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/mortality ; Survival Rate/trends
Czasopismo naukowe
Tytuł :
SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1.
Autorzy :
Zheng B; Department of Urologic Surgery, Ningbo Yinzhou Second Hospital, Ningbo 315100, China.
Wang G; Department of Urologic Surgery, Ningbo Yinzhou Second Hospital, Ningbo 315100, China.
Gao W; Department of Urologic Surgery, Ningbo Yinzhou Second Hospital, Ningbo 315100, China.
Wu Q; Department of Urologic Surgery, Ningbo Yinzhou Second Hospital, Ningbo 315100, China.
Zhu W; Department of Urologic Surgery, Ningbo Yinzhou Second Hospital, Ningbo 315100, China.
Weng G; Department of Urologic Surgery, Ningbo Yinzhou Second Hospital, Ningbo 315100, China.
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Źródło :
Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2020 Jun 01; Vol. 70 (2), pp. 191-200.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclin D1/*genetics
Diosgenin/*analogs & derivatives
Down-Regulation/*drug effects
G1 Phase/*drug effects
Resting Phase, Cell Cycle/*drug effects
SOXF Transcription Factors/*genetics
Saponins/*pharmacology
Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cyclin-Dependent Kinase 4/genetics ; Cyclin-Dependent Kinase 6/genetics ; Diosgenin/pharmacology ; Down-Regulation/genetics ; G1 Phase/genetics ; Humans ; Male ; PC-3 Cells ; Resting Phase, Cell Cycle/genetics
Czasopismo naukowe
Tytuł :
BARX2 expression is downregulated by CpG island hypermethylation and is associated with suppressed cell proliferation and invasion of gastric cancer cells.
Autorzy :
Ma J; Department of Gastroenterology and Hepatology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, and Guangdong Provincial Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China.
Xia LL; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518000, P.R. China.
Yao XQ; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China.
Zheng SM; Department of Gastroenterology and Hepatology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, and Guangdong Provincial Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China.
Li S; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518000, P.R. China.
Xu LS; Department of Gastroenterology and Hepatology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, and Guangdong Provincial Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China.
Sha WH; Department of Gastroenterology and Hepatology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, and Guangdong Provincial Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China.
Li ZS; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518000, P.R. China.
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Źródło :
Oncology reports [Oncol Rep] 2020 Jun; Vol. 43 (6), pp. 1805-1818. Date of Electronic Publication: 2020 Mar 22.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Down-Regulation*
Homeodomain Proteins/*genetics
Homeodomain Proteins/*metabolism
Stomach Neoplasms/*pathology
Adult ; Aged ; Aged, 80 and over ; Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; CpG Islands ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Mice, Nude ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Transplantation ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation.
Autorzy :
Munir J; Soonchunhyang Institute of Medi-bioscience (SIMS), Soonchunhyang University, Cheonan, South Korea; Department of Integrated Biomedicine, Soonchunhyang University, Cheonan, South Korea. Electronic address: .
Van Ngu T; Soonchunhyang Institute of Medi-bioscience (SIMS), Soonchunhyang University, Cheonan, South Korea; Department of Integrated Biomedicine, Soonchunhyang University, Cheonan, South Korea. Electronic address: .
Na Ayudthaya PD; Soonchunhyang Institute of Medi-bioscience (SIMS), Soonchunhyang University, Cheonan, South Korea; Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand. Electronic address: .
Ryu S; Soonchunhyang Institute of Medi-bioscience (SIMS), Soonchunhyang University, Cheonan, South Korea; Department of Integrated Biomedicine, Soonchunhyang University, Cheonan, South Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 May 21; Vol. 526 (1), pp. 91-97. Date of Electronic Publication: 2020 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement*
Disease Progression*
Down-Regulation*
Breast Neoplasms/*metabolism
Breast Neoplasms/*pathology
Glypicans/*metabolism
Cell Line, Tumor ; Cell Proliferation ; Female ; Humans ; Neoplasm Invasiveness ; Neoplasm Metastasis
Czasopismo naukowe
Tytuł :
Inhibition of Jurkat T Cell Growth by N -farnesyl-norcantharimide Through Up-regulation of Tumor Suppressor Genes and Down-regulation of Genes for Steroid Biosynthesis, Metabolic Pathways and Fatty Acid Metabolism.
Autorzy :
Wu JY; Department of Microbiology, Immunology and Biopharmaceutics, College of Life Sciences, National Chiayi University, Chiayi, Taiwan, R.O.C.
Tsai ET; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
Yang FY; Department of Microbiology, Immunology and Biopharmaceutics, College of Life Sciences, National Chiayi University, Chiayi, Taiwan, R.O.C.
Lin JF; Division of Neurosurgery, Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan, R.O.C.; Institute of Traditional Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
Liao HF; Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan, R.O.C.
Chen YJ; Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan, R.O.C.
Kuo CD; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C. .; Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.; Tanyu Research Laboratory, Taipei, Taiwan, R.O.C.
Pokaż więcej
Źródło :
Anticancer research [Anticancer Res] 2020 May; Vol. 40 (5), pp. 2675-2685.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Tumor Suppressor*
Cantharidin/*analogs & derivatives
Down-Regulation/*drug effects
Fatty Acids/*metabolism
Metabolic Networks and Pathways/*genetics
Steroids/*biosynthesis
T-Lymphocytes/*cytology
Up-Regulation/*drug effects
Apoptosis/drug effects ; Apoptosis/genetics ; Biosynthetic Pathways/drug effects ; Biosynthetic Pathways/genetics ; Cantharidin/chemistry ; Cantharidin/pharmacology ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Proliferation/drug effects ; DNA, Neoplasm/metabolism ; Down-Regulation/genetics ; Humans ; Jurkat Cells ; Metabolic Networks and Pathways/drug effects ; T-Lymphocytes/drug effects ; Up-Regulation/genetics
Czasopismo naukowe

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