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Tytuł :
Downregulation of a novel flagellar synthesis regulator AsiR promotes intracellular replication and systemic pathogenicity of Salmonella typhimurium.
Autorzy :
Ma S; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University , Tianjin, China.; TEDA Institute of Biological Sciences and Biotechnology, Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University , Tianjin, China.
Jiang L; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University , Tianjin, China.; TEDA Institute of Biological Sciences and Biotechnology, Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University , Tianjin, China.
Wang J; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University , Tianjin, China.; TEDA Institute of Biological Sciences and Biotechnology, Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University , Tianjin, China.
Liu X; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University , Tianjin, China.; TEDA Institute of Biological Sciences and Biotechnology, Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University , Tianjin, China.
Li W; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University , Tianjin, China.; TEDA Institute of Biological Sciences and Biotechnology, Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University , Tianjin, China.
Ma S; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University , Tianjin, China.; TEDA Institute of Biological Sciences and Biotechnology, Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University , Tianjin, China.
Feng L; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University , Tianjin, China.; TEDA Institute of Biological Sciences and Biotechnology, Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University , Tianjin, China.
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Źródło :
Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 298-311.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Gene Expression Regulation, Bacterial*
Bacterial Proteins/*genetics
Flagellin/*genetics
Macrophages/*microbiology
Salmonella typhimurium/*genetics
Salmonella typhimurium/*pathogenicity
Animals ; Cytokines/immunology ; DNA Replication ; Female ; Flagellin/immunology ; Gene Expression ; Macrophages/immunology ; Mice ; Mice, Inbred BALB C ; Salmonella Infections/blood ; Salmonella Infections/immunology ; Salmonella Infections/microbiology ; Salmonella typhimurium/physiology
Czasopismo naukowe
Tytuł :
Interleukin-37 is down-regulated in serum of patients with severe coronavirus disease 2019 (COVID-19).
Autorzy :
Ahmed AA; Biotechnology Department, College of Science, University of Baghdad, Baghdad, Iraq.
Ad'hiah AH; Tropical-Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq. Electronic address: .
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Źródło :
Cytokine [Cytokine] 2021 Dec; Vol. 148, pp. 155702. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Severity of Illness Index*
COVID-19/*blood
COVID-19/*pathology
Interleukin-1/*blood
Aged ; COVID-19/virology ; Case-Control Studies ; Confidence Intervals ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; ROC Curve ; SARS-CoV-2/physiology ; Statistics, Nonparametric
Czasopismo naukowe
Tytuł :
AGEs/RAGE blockade downregulates Endothenin-1 (ET-1), mitigating Human Umbilical Vein Endothelial Cells (HUVEC) injury in deep vein thrombosis (DVT).
Autorzy :
Zhang Y; Department of Vascular Surgery, 1-7 Beijing Jishuitan Hospital, Beijing, China.
Liu J; Department of Vascular Surgery, 1-7 Beijing Jishuitan Hospital, Beijing, China.
Jia W; Department of Vascular Surgery, 1-7 Beijing Jishuitan Hospital, Beijing, China.
Tian X; Department of Vascular Surgery, 1-7 Beijing Jishuitan Hospital, Beijing, China.
Jiang P; Department of Vascular Surgery, 1-7 Beijing Jishuitan Hospital, Beijing, China.
Cheng Z; Department of Vascular Surgery, 1-7 Beijing Jishuitan Hospital, Beijing, China.
Li J; Department of Vascular Surgery, 1-7 Beijing Jishuitan Hospital, Beijing, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 1360-1368.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Antigens, Neoplasm/*metabolism
Endothelin-1/*metabolism
Glycation End Products, Advanced/*metabolism
Human Umbilical Vein Endothelial Cells/*metabolism
Mitogen-Activated Protein Kinases/*metabolism
Venous Thrombosis/*metabolism
Caspase 3/metabolism ; Cell Survival ; Glycosylation ; Humans ; Inflammation/pathology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Oxidative Stress ; Serum Albumin/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Pyrroloquinoline quinone (PQQ) alleviated sepsis-induced acute liver injury, inflammation, oxidative stress and cell apoptosis by downregulating CUL3 expression.
Autorzy :
Wu Y; Department of Critical Care Medicine, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan Province, China.
Zhao M; Department of Critical Care Medicine, Zibo Central Hospital, Zibo, Shandong Province, China.
Lin Z; Department of Critical Care Medicine, The People's Hospital of Xishuangbanna Dai Nationality Autonomous Prefecture, Jinghong, Yunnan Province, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 2459-2468.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Down-Regulation*/drug effects
Oxidative Stress*
Cullin Proteins/*metabolism
Inflammation/*pathology
Liver/*injuries
PQQ Cofactor/*pharmacology
Sepsis/*complications
Acute Disease ; Animals ; Kupffer Cells/drug effects ; Kupffer Cells/metabolism ; Kupffer Cells/pathology ; Lipopolysaccharides ; Liver/drug effects ; Liver/pathology ; Rats, Sprague-Dawley ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Effects of silencing epididymal vascular endothelial growth factor (VEGF) expression on hyaluronidase (HYD) activity in arsenic poisoning rats through downregulating VEGF receptor 2 (VEGFR2).
Autorzy :
Dai YP; Department of Pathology and Pathophysiology, College of Basic Medical Science, Guizhou Medical University, Guiyang, Guizhou, China.; Department of Internal Medicine, People's Hospital in Yueyanglou District, Yueyang, Hunan, China.; Centre for Reproductive Research, National School of Medicine Guiyang Medical University Magic, Guiyang, Guizhou, China.
Gao XQ; Department of Pathology and Pathophysiology, College of Basic Medical Science, Guizhou Medical University, Guiyang, Guizhou, China.; Centre for Reproductive Research, National School of Medicine Guiyang Medical University Magic, Guiyang, Guizhou, China.; Department of Histology and Embryology, Zunyi Medical and Pharmaceutical College, Zunyi, Guizhou, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 1351-1359.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Gene Silencing*
Arsenic Poisoning/*enzymology
Arsenic Poisoning/*genetics
Epididymis/*metabolism
Hyaluronoglucosaminidase/*metabolism
Vascular Endothelial Growth Factor A/*genetics
Vascular Endothelial Growth Factor Receptor-2/*genetics
Animals ; Male ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/metabolism ; Rats, Sprague-Dawley ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Czasopismo naukowe
Tytuł :
Down-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells.
Autorzy :
Wang X; Department of Endocrinology, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, Liaoning P.R. China.
Mi Y; Department of Endocrinology, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, Liaoning P.R. China.
He W; Department of Endocrinology, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, Liaoning P.R. China.
Hu X; Department of Endocrinology, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, Liaoning P.R. China.
Yang S; Department of Endocrinology, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, Liaoning P.R. China.
Zhao L; Department of Endocrinology, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, Liaoning P.R. China.
Zhang Y; Department of Endocrinology, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, Liaoning P.R. China.
Wen B; Department of Endocrinology, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, Liaoning P.R. China.; Department of Endocrinology, Dalian Medical University, Dalian, Liaoning, P.R. China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 1126-1137.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Cell Differentiation/*genetics
Core Binding Factor Alpha 1 Subunit/*genetics
Down-Regulation/*genetics
Osteogenesis/*genetics
Animals ; Base Sequence ; Cell Line ; Core Binding Factor Alpha 1 Subunit/metabolism ; Diabetes Mellitus/genetics ; Diabetes Mellitus/pathology ; Disease Models, Animal ; Down-Regulation/drug effects ; Glucose/toxicity ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Osteoporosis/complications ; Osteoporosis/genetics ; Osteoporosis/pathology ; Rats ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Downregulation of interferon-induced protein with tetratricopeptide repeats 3 relieves the inflammatory response and myocardial fibrosis of mice with myocardial infarction and improves their cardiac function.
Autorzy :
Sun J; Department of Internal Medicine, Hebei Medical University, No. 361, Zhongshan East Road, Chang'an District, Shijiazhuang, Hebei Province 050017, P.R. China.; Department of Cardiology, Tangshan Gongren Hospital Affiliated to Hebei Medical University, No. 27, Wenhua Road, Lubei District, Tangshan, Hebei Province 063000, P.R. China.
Zhang Q; Department of Internal Medicine, Hebei Medical University, No. 361, Zhongshan East Road, Chang'an District, Shijiazhuang, Hebei Province 050017, P.R. China.
Liu X; Department of Internal Medicine, Hebei Medical University, No. 361, Zhongshan East Road, Chang'an District, Shijiazhuang, Hebei Province 050017, P.R. China.
Shang X; Department of Internal Medicine, Hebei Medical University, No. 361, Zhongshan East Road, Chang'an District, Shijiazhuang, Hebei Province 050017, P.R. China.
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Źródło :
Experimental animals [Exp Anim] 2021 Nov 10; Vol. 70 (4), pp. 522-531. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Fibrosis/*genetics
Heart/*physiopathology
Inflammation/*genetics
Intracellular Signaling Peptides and Proteins/*genetics
Animals ; Fibrosis/immunology ; Inflammation/immunology ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Myocardial Infarction/physiopathology
Czasopismo naukowe
Tytuł :
Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells.
Autorzy :
Lu Y; Department of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, 211166, China; Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, 211166, China.
Zhang M; Department of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, 211166, China.
Wei Q; Department of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, 211166, China; Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, 211166, China.
Chen Z; Department of Otolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210009, China.
Xing G; Department of Otolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210009, China.
Yao J; Department of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, 211166, China; Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, 211166, China. Electronic address: .
Cao X; Department of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, 211166, China; Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, 211166, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Oct 15; Vol. 574, pp. 1-7. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Down-Regulation*
Hedgehog Proteins/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Animals ; Cells, Cultured ; Intracellular Signaling Peptides and Proteins/deficiency ; Male ; Mice ; Mice, Knockout ; Signal Transduction
Czasopismo naukowe
Tytuł :
Reciprocal deregulation of NKX3.1 and AURKA axis in castration-resistant prostate cancer and NEPC models.
Autorzy :
Sooreshjani MA; Department of Chemistry and Purdue University Center for Cancer Research, 560 Oval Drive, West Lafayette, IN, 47907, USA.
Kamra M; Department of Chemistry and Purdue University Center for Cancer Research, 560 Oval Drive, West Lafayette, IN, 47907, USA.
Zoubeidi A; Urologic Sciences, University of British Columbia, Vancouver, V6H 3Z6, Canada.
Shah K; Department of Chemistry and Purdue University Center for Cancer Research, 560 Oval Drive, West Lafayette, IN, 47907, USA. .
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Źródło :
Journal of biomedical science [J Biomed Sci] 2021 Oct 08; Vol. 28 (1), pp. 68. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Gene Expression Regulation, Neoplastic*
Aurora Kinase A/*genetics
Homeodomain Proteins/*genetics
Prostatic Neoplasms/*genetics
Transcription Factors/*genetics
Aurora Kinase A/metabolism ; Castration ; Homeodomain Proteins/metabolism ; Humans ; Male ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
miR-19a-3p downregulates tissue factor and functions as a potential therapeutic target for sepsis-induced disseminated intravascular coagulation.
Autorzy :
Zhang R; Department of Pediatrics, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China.
Lu S; Precision Medicine Key Laboratory of Sichuan Province and Precision Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Yang X; Department of Pathology, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China.
Li M; Department of Pediatrics, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China.
Jia H; Department of Pediatrics, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China.
Liao J; Department of Pediatrics, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China.
Jing Q; Department of Pediatrics, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China.
Wu Y; Department of Pediatrics, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China.
Wang H; Department of Pediatrics, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China.
Xiao F; Department of Pediatrics, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China.
Bai X; Department of Pediatrics, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China.
Na X; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.
Kang Y; Institute of Environmental Information, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address: .
Wan L; Department of Ophthalmology, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China. Electronic address: .
Yang J; The Key Laboratory for Human Disease Gene Study of Sichuan Province, Prenatal Diagnosis Center, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West section2, 1st ring road, Qingyang District, Chengdu, Sichuan 610072, China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Oct; Vol. 192, pp. 114671. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disseminated Intravascular Coagulation/*metabolism
Down-Regulation/*physiology
Human Umbilical Vein Endothelial Cells/*metabolism
MicroRNAs/*biosynthesis
Sepsis/*metabolism
Thromboplastin/*metabolism
Animals ; Cells, Cultured ; Disseminated Intravascular Coagulation/chemically induced ; Down-Regulation/drug effects ; Female ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Infant, Newborn ; Lipopolysaccharides/toxicity ; Male ; Rats ; Rats, Sprague-Dawley ; Sepsis/chemically induced ; Thromboplastin/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
MiR-145 suppresses the motility of prostate cancer cells by targeting cadherin-2.
Autorzy :
Zeng H; Department of General Practice Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, People's Republic of China.
Huang Y; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, 510630, People's Republic of China.
Liu Q; Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, People's Republic of China.
Liu H; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, People's Republic of China.
Long T; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, People's Republic of China.
Zhu C; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, People's Republic of China. .
Wu X; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, 510630, People's Republic of China. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Oct; Vol. 476 (10), pp. 3635-3646. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Gene Expression Regulation, Neoplastic*
Antigens, CD/*biosynthesis
Cadherins/*biosynthesis
MicroRNAs/*metabolism
Neoplasm Proteins/*biosynthesis
Prostatic Neoplasms/*metabolism
RNA, Neoplasm/*metabolism
Antigens, CD/genetics ; Cadherins/genetics ; Cell Movement ; HEK293 Cells ; Humans ; Male ; MicroRNAs/genetics ; Neoplasm Invasiveness ; Neoplasm Proteins/genetics ; PC-3 Cells ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; RNA, Neoplasm/genetics
Czasopismo naukowe
Tytuł :
MiR-145 regulates steroidogenesis in mouse primary granulosa cells through targeting Crkl.
Autorzy :
Wang S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Tang W; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Ma L; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China; Department of Obstetrics and Gynecology, Guiyang Maternity and Child Health Care Hospital, Guiyang, Guizhou, People's Republic of China.
Yang J; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China; Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Huang K; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Du X; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China; Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Luo A; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Shen W; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Ding T; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Ye S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Zhou S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Yang S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address: .
Wang S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Oct 01; Vol. 282, pp. 119820. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
Cell Proliferation*
Down-Regulation*
MAP Kinase Signaling System*
Adaptor Proteins, Signal Transducing/*biosynthesis
Granulosa Cells/*metabolism
MicroRNAs/*biosynthesis
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Female ; Mice ; MicroRNAs/genetics
Czasopismo naukowe
Tytuł :
Down-expression of TaPIN1s Increases the Tiller Number and Grain Yield in Wheat.
Autorzy :
Yao FQ; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, 271018, Shandong, China.
Li XH; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, 271018, Shandong, China.
Wang H; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, 271018, Shandong, China.
Song YN; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, 271018, Shandong, China.
Li ZQ; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, 271018, Shandong, China.
Li XG; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, 271018, Shandong, China.
Gao XQ; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, 271018, Shandong, China.
Zhang XS; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, 271018, Shandong, China.
Bie XM; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, 271018, Shandong, China. .
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Źródło :
BMC plant biology [BMC Plant Biol] 2021 Sep 30; Vol. 21 (1), pp. 443. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Membrane Transport Proteins/*metabolism
Plant Stems/*growth & development
Seeds/*growth & development
Triticum/*genetics
Triticum/*growth & development
Triticum/*metabolism
Edible Grain/genetics ; Edible Grain/growth & development ; Edible Grain/metabolism ; Gene Expression Regulation, Plant ; Genes, Plant ; Plant Stems/genetics ; Plant Stems/metabolism ; Seeds/genetics ; Seeds/metabolism
Czasopismo naukowe
Tytuł :
Low expression of CIP4 in predicting worse overall survival: A potential biomarker for laryngeal cancer.
Autorzy :
Fang L; First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Shi L; First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wang W; First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wu X; Wenzhou Medical University, Wenzhou, Zhejiang, China.
Hu T; First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Huang Y; First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Rao X; First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
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Źródło :
PloS one [PLoS One] 2021 Sep 27; Vol. 16 (9), pp. e0253545. Date of Electronic Publication: 2021 Sep 27 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Biomarkers, Tumor/*genetics
Gene Expression Profiling/*methods
Laryngeal Neoplasms/*mortality
Microtubule-Associated Proteins/*genetics
Minor Histocompatibility Antigens/*genetics
Female ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/pathology ; Male ; Neoplasm Grading ; Prognosis ; Signal Transduction ; Survival Analysis
Czasopismo naukowe
Tytuł :
SPPL3-dependent downregulation of the synthesis of (neo)lacto-series glycosphingolipid is required for the staining of cell surface CD59.
Autorzy :
Kawaguchi K; Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo, 171-8501, Japan.
Yamamoto-Hino M; Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo, 171-8501, Japan.
Goto S; Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo, 171-8501, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Sep 24; Vol. 571, pp. 81-87. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Aspartic Acid Endopeptidases/*metabolism
Glycosphingolipids/*biosynthesis
Cells, Cultured ; Glycosphingolipids/chemistry ; HEK293 Cells ; Humans ; Surface Properties
Czasopismo naukowe
Tytuł :
PHLDA3 exerts an antitumor function in prostate cancer by down-regulating Wnt/β-catenin pathway via inhibition of Akt.
Autorzy :
Ma S; Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Quan P; Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Yu C; Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Fan X; Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Yang S; The Santa Catalina School, 1500 Mark Thomas Drive, Monterey, CA, 93940, USA.
Jia W; Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Zhang L; Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Wang F; Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Liu F; Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Yang L; Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Qin W; Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Yang X; Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Sep 24; Vol. 571, pp. 66-73. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Nuclear Proteins/*metabolism
Prostatic Neoplasms/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
beta Catenin/*metabolism
Animals ; Apoptosis ; Cell Proliferation ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Nuclear Proteins/genetics ; Prostatic Neoplasms/pathology ; Tumor Cells, Cultured ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization.
Autorzy :
Wu K; Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Korea.
Woo SM; Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Korea.
Seo SU; Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Korea.
Kwon TK; Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Korea.; Center for Forensic Pharmaceutical Science, Keimyung University, Daegu 42601, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 18; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 18.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Down-Regulation*
Gene Expression Regulation, Neoplastic*
Benzimidazoles/*pharmacology
Endopeptidases/*metabolism
Myeloid Cell Leukemia Sequence 1 Protein/*metabolism
Polycomb Repressive Complex 1/*antagonists & inhibitors
Pyrazines/*pharmacology
A549 Cells ; Body Mass Index ; Caspase 3/metabolism ; Cell Death ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA Fragmentation ; Enzyme Activation ; HeLa Cells ; Humans ; Neoplastic Stem Cells/metabolism ; RNA, Small Interfering/metabolism ; Ubiquitin/chemistry
Czasopismo naukowe
Tytuł :
Activation of the aryl hydrocarbon receptor by 3-methylcholanthrene, but not by indirubin, suppresses mammosphere formation via downregulation of CDC20 expression in breast cancer cells.
Autorzy :
Yamashita N; Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto, 610-0395, Japan. Electronic address: .
Yoshizuka A; Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto, 610-0395, Japan.
Kase A; Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto, 610-0395, Japan.
Ozawa M; Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto, 610-0395, Japan.
Taga C; Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto, 610-0395, Japan.
Sanada N; Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto, 610-0395, Japan.
Kanno Y; Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Nemoto K; Department of Molecular Toxicology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan.
Kizu R; Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto, 610-0395, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Sep 17; Vol. 570, pp. 131-136. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*/drug effects
Breast Neoplasms/*genetics
Cdc20 Proteins/*metabolism
Methylcholanthrene/*pharmacology
Receptors, Aryl Hydrocarbon/*metabolism
Spheroids, Cellular/*pathology
Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Indoles/pharmacology ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/metabolism ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Identification of calmodulin-like protein 5 as tumor-suppressor gene silenced during early stage of carcinogenesis in squamous cell carcinoma of uterine cervix.
Autorzy :
Kitazawa S; Department of Molecular Pathology, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan.
Takaoka Y; Department of Molecular Pathology, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan.
Ueda Y; Department of Molecular Pathology, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan.; Division of Diagnostic Pathology, Ehime University Hospital, Toon City, Ehime, Japan.
Kitazawa R; Division of Diagnostic Pathology, Ehime University Hospital, Toon City, Ehime, Japan.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Sep 15; Vol. 149 (6), pp. 1358-1368. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Calcium-Binding Proteins/*genetics
Carcinoma, Squamous Cell/*pathology
Kruppel-Like Transcription Factors/*metabolism
Transcription Factors/*metabolism
Tumor Suppressor Proteins/*metabolism
Uterine Cervical Neoplasms/*pathology
Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Cell Line, Tumor ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; HL-60 Cells ; Humans ; Neoplasm Staging ; Promoter Regions, Genetic ; Protein Transport ; Transcription, Genetic ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Targeted Downregulation of MYC through G-quadruplex Stabilization by DNAi.
Autorzy :
Psaras AM; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Binghamton University, Binghamton, NY 13902, USA.
Chang KT; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Binghamton University, Binghamton, NY 13902, USA.
Hao T; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Brooks TA; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Binghamton University, Binghamton, NY 13902, USA.; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 13; Vol. 26 (18). Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Proto-Oncogene Proteins c-myc*
G-Quadruplexes ; Humans ; Promoter Regions, Genetic
Czasopismo naukowe

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