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    Wyświetlanie 1-19 z 19
    Tytuł:
    Bacterial Lipid II Analogs: Novel In Vitro Substrates for Mammalian Oligosaccharyl Diphosphodolichol Diphosphatase (DLODP) Activities.
    Autorzy:
    Massarweh A; Université de Paris, INSERM U1149, 16 rue Henri Huchard, 75018 Paris, France. .
    Bosco M; Université de Paris, CICB-Paris, CNRS UMR8601, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, 45 rue des Saints-Pères, 75006 Paris, France. mik_.
    Chantret I; Université de Paris, INSERM U1149, 16 rue Henri Huchard, 75018 Paris, France. .
    Léger T; Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, Université de Paris, CNRS, F-75205 Paris, France. .
    Jamal L; Université de Paris, INSERM U1149, 16 rue Henri Huchard, 75018 Paris, France. .
    Roper DI; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK. .
    Dowson CG; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK. C.G.Dowson@warwick.ac.uk.
    Busca P; Université de Paris, CICB-Paris, CNRS UMR8601, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, 45 rue des Saints-Pères, 75006 Paris, France. .
    Bouhss A; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris-Sud, Université Paris-Saclay, 91198 Gif-sur-Yvette, France. .; Laboratoire Structure-Activité des Biomolécules Normales et Pathologiques (SABNP), Univ Evry, INSERM U1204, Université Paris-Saclay, 91025 Evry, France. .
    Gravier-Pelletier C; Université de Paris, CICB-Paris, CNRS UMR8601, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, 45 rue des Saints-Pères, 75006 Paris, France. .
    Moore SEH; Université de Paris, INSERM U1149, 16 rue Henri Huchard, 75018 Paris, France. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2019 Jun 06; Vol. 24 (11). Date of Electronic Publication: 2019 Jun 06.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Acetylglucosamine/*chemistry
    Endoplasmic Reticulum/*chemistry
    Liver/*chemistry
    Oligosaccharides/*chemistry
    Animals ; Bacteria/chemistry ; Endoplasmic Reticulum/metabolism ; Eukaryotic Cells/chemistry ; Eukaryotic Cells/metabolism ; Glucose/chemistry ; Glycosylation ; Hep G2 Cells ; Humans ; Hydrolysis ; Lipids/chemistry ; Liver/metabolism ; Mannose/chemistry ; Mice ; Oligosaccharides/metabolism ; Uridine Diphosphate N-Acetylmuramic Acid/analogs & derivatives ; Uridine Diphosphate N-Acetylmuramic Acid/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB.
    Autorzy:
    Hrast M; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
    Jukič M; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
    Patin D; Group Bacterial Cell Envelopes and Antibiotics, Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris Sud, Université Paris-Saclay, Gif-sur-Yvette Cedex, France.
    Tod J; School of Life Sciences, University of Warwick, Coventry, UK.
    Dowson CG; School of Life Sciences, University of Warwick, Coventry, UK.
    Roper DI; School of Life Sciences, University of Warwick, Coventry, UK.
    Barreteau H; Group Bacterial Cell Envelopes and Antibiotics, Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris Sud, Université Paris-Saclay, Gif-sur-Yvette Cedex, France.
    Gobec S; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
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    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2018 Jun; Vol. 91 (6), pp. 1101-1112. Date of Electronic Publication: 2018 Feb 12.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Anti-Bacterial Agents/*chemical synthesis
    Bacterial Proteins/*antagonists & inhibitors
    Carbohydrate Dehydrogenases/*antagonists & inhibitors
    Tetrazoles/*chemistry
    Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/metabolism ; Binding Sites ; Carbohydrate Dehydrogenases/metabolism ; Catalytic Domain ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Escherichia coli/drug effects ; Escherichia coli/enzymology ; Kinetics ; Molecular Docking Simulation ; Staphylococcus aureus/drug effects ; Structure-Activity Relationship ; Tetrazoles/metabolism ; Tetrazoles/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Touching proteins with virtual bare hands : Visualizing protein-drug complexes and their dynamics in self-made virtual reality using gaming hardware.
    Autorzy:
    Ratamero EM; Department of Physics and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
    Bellini D; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
    Dowson CG; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
    Römer RA; Department of Physics, University of Warwick, Coventry, CV4 7AL, UK. .
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    Źródło:
    Journal of computer-aided molecular design [J Comput Aided Mol Des] 2018 Jun; Vol. 32 (6), pp. 703-709. Date of Electronic Publication: 2018 Jun 07.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Computer Simulation*
    Virtual Reality*
    Proteins/*chemistry
    Algorithms ; Drug Design ; Humans ; Protein Conformation ; Software ; User-Computer Interface
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA).
    Autorzy:
    Sychantha D; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
    Jones CS; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
    Little DJ; Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto ON, Canada.; Department of Biochemistry, University of Toronto, 1 King's College Cir, Toronto, ON, Canada.
    Moynihan PJ; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.
    Robinson H; Photon Science Division, Brookhaven National Laboratory, Upton, New York, United States of America.
    Galley NF; School of Life Sciences, University of Warwick, Coventry, United Kingdom.
    Roper DI; School of Life Sciences, University of Warwick, Coventry, United Kingdom.
    Dowson CG; School of Life Sciences, University of Warwick, Coventry, United Kingdom.
    Howell PL; Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto ON, Canada.; Department of Biochemistry, University of Toronto, 1 King's College Cir, Toronto, ON, Canada.
    Clarke AJ; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2017 Oct 27; Vol. 13 (10), pp. e1006667. Date of Electronic Publication: 2017 Oct 27 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Acetyltransferases/*metabolism
    Gram-Positive Bacteria/*metabolism
    Peptidoglycan/*metabolism
    Staphylococcus aureus/*drug effects
    Virulence Factors/*metabolism
    Bacterial Proteins/metabolism ; Cell Wall/metabolism ; Drug Resistance ; Humans ; Peptidoglycan/pharmacology ; Staphylococcus aureus/pathogenicity ; Substrate Specificity/immunology ; Virulence
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase.
    Autorzy:
    Usha V; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
    Lloyd AJ; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
    Roper DI; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
    Dowson CG; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
    Kozlov G; Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada.
    Gehring K; Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada.
    Chauhan S; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
    Imam HT; Department of Chemistry, University of Warwick, Coventry, CV4 7AL,UK.
    Blindauer CA; Department of Chemistry, University of Warwick, Coventry, CV4 7AL,UK.
    Besra GS; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
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    Źródło:
    Scientific reports [Sci Rep] 2016 Mar 15; Vol. 6, pp. 23191. Date of Electronic Publication: 2016 Mar 15.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Amidohydrolases/*chemistry
    Bacterial Proteins/*chemistry
    Diaminopimelic Acid/*metabolism
    Mycobacterium tuberculosis/*enzymology
    Amidohydrolases/antagonists & inhibitors ; Amidohydrolases/metabolism ; Bacterial Proteins/metabolism ; Binding Sites ; Captopril/pharmacology ; Diaminopimelic Acid/chemistry ; Histidine/chemistry ; Oligopeptides/chemistry ; Zinc/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis.
    Autorzy:
    Pacheco LG; Department of General Biology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av, Antônio Carlos, Belo Horizonte, 31,270-901, Brazil.
    Slade SE
    Seyffert N
    Santos AR
    Castro TL
    Silva WM
    Santos AV
    Santos SG
    Farias LM
    Carvalho MA
    Pimenta AM
    Meyer R
    Silva A
    Scrivens JH
    Oliveira SC
    Miyoshi A
    Dowson CG
    Azevedo V
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    Źródło:
    BMC microbiology [BMC Microbiol] 2011 Jan 17; Vol. 11 (1), pp. 12. Date of Electronic Publication: 2011 Jan 17.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Bacterial Proteins/*analysis
    Corynebacterium pseudotuberculosis/*metabolism
    Proteomics/*methods
    Chromatography, Liquid ; Mass Spectrometry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Novel Corynebacterium diphtheriae in domestic cats.
    Autorzy:
    Hall AJ; Division of Viral Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop A47, Atlanta, GA 30333, USA. />Cassiday PK
    Bernard KA
    Bolt F
    Steigerwalt AG
    Bixler D
    Pawloski LC
    Whitney AM
    Iwaki M
    Baldwin A
    Dowson CG
    Komiya T
    Takahashi M
    Hinrikson HP
    Tondella ML
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    Źródło:
    Emerging infectious diseases [Emerg Infect Dis] 2010 Apr; Vol. 16 (4), pp. 688-91.
    Typ publikacji:
    Case Reports; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cat Diseases/*microbiology
    Corynebacterium diphtheriae/*isolation & purification
    Diphtheria/*veterinary
    Animals ; Animals, Domestic/microbiology ; Cats/microbiology ; Corynebacterium diphtheriae/genetics ; Diphtheria/microbiology ; Female ; Humans ; Phylogeny ; West Virginia
    Czasopismo naukowe
    Szczegóły
    Tytuł:
    Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.
    Autorzy:
    Holden MT; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom. />Hauser H
    Sanders M
    Ngo TH
    Cherevach I
    Cronin A
    Goodhead I
    Mungall K
    Quail MA
    Price C
    Rabbinowitsch E
    Sharp S
    Croucher NJ
    Chieu TB
    Mai NT
    Diep TS
    Chinh NT
    Kehoe M
    Leigh JA
    Ward PN
    Dowson CG
    Whatmore AM
    Chanter N
    Iversen P
    Gottschalk M
    Slater JD
    Smith HE
    Spratt BG
    Xu J
    Ye C
    Bentley S
    Barrell BG
    Schultsz C
    Maskell DJ
    Parkhill J
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2009 Jul 15; Vol. 4 (7), pp. e6072. Date of Electronic Publication: 2009 Jul 15.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Resistance, Microbial/*genetics
    Streptococcus suis/*pathogenicity
    Virulence/*genetics
    Zoonoses/*microbiology
    Animals ; DNA, Bacterial/genetics ; Disease Outbreaks ; Genome, Bacterial ; Humans ; Phylogeny ; Streptococcal Infections/epidemiology ; Streptococcal Infections/microbiology ; Streptococcus suis/classification ; Streptococcus suis/drug effects ; Streptococcus suis/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis.
    Autorzy:
    Ward PN; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. />Holden MT
    Leigh JA
    Lennard N
    Bignell A
    Barron A
    Clark L
    Quail MA
    Woodward J
    Barrell BG
    Egan SA
    Field TR
    Maskell D
    Kehoe M
    Dowson CG
    Chanter N
    Whatmore AM
    Bentley SD
    Parkhill J
    Pokaż więcej
    Źródło:
    BMC genomics [BMC Genomics] 2009 Jan 28; Vol. 10, pp. 54. Date of Electronic Publication: 2009 Jan 28.
    Typ publikacji:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genome, Bacterial*
    Adaptation, Biological/*genetics
    Streptococcus/*genetics
    Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cattle ; Comparative Genomic Hybridization ; DNA, Bacterial/genetics ; Evolution, Molecular ; Gene Expression Profiling ; Genes, Bacterial ; Genomic Islands ; Mastitis, Bovine/microbiology ; Phylogeny ; Sequence Analysis, DNA ; Streptococcus/metabolism ; Streptococcus/pathogenicity ; Virulence
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Diversity of the parB and repA genes of the Burkholderia cepacia complex and their utility for rapid identification of Burkholderia cenocepacia.
    Autorzy:
    Drevinek P; Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3TL, UK. />Baldwin A
    Dowson CG
    Mahenthiralingam E
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    Źródło:
    BMC microbiology [BMC Microbiol] 2008 Mar 07; Vol. 8, pp. 44. Date of Electronic Publication: 2008 Mar 07.
    Typ publikacji:
    Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Bacterial Typing Techniques*
    Genetic Variation*
    Bacterial Proteins/*genetics
    Burkholderia Infections/*microbiology
    Burkholderia cepacia complex/*isolation & purification
    Replication Protein A/*genetics
    Base Sequence ; Burkholderia cepacia complex/classification ; Burkholderia cepacia complex/genetics ; DNA Primers/genetics ; Genome, Bacterial ; Humans ; Molecular Sequence Data ; Phylogeny ; Polymerase Chain Reaction/methods ; Sensitivity and Specificity ; Sequence Alignment ; Sequence Analysis, DNA ; Species Specificity
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Environmental Burkholderia cepacia complex isolates in human infections.
    Autorzy:
    Baldwin A; Warwick University, Coventry, Wales, United Kingdom.
    Mahenthiralingam E
    Drevinek P
    Vandamme P
    Govan JR
    Waine DJ
    LiPuma JJ
    Chiarini L
    Dalmastri C
    Henry DA
    Speert DP
    Honeybourne D
    Maiden MC
    Dowson CG
    Pokaż więcej
    Źródło:
    Emerging infectious diseases [Emerg Infect Dis] 2007 Mar; Vol. 13 (3), pp. 458-61.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Burkholderia Infections/*microbiology
    Burkholderia cepacia complex/*classification
    Communicable Diseases, Emerging/*microbiology
    Australia ; Burkholderia cepacia complex/genetics ; DNA, Bacterial/genetics ; Europe ; Genetic Variation ; Humans ; North America ; Sequence Analysis, DNA ; Soil Microbiology ; Species Specificity ; Thailand
    Czasopismo naukowe
    Szczegóły
      Wyświetlanie 1-19 z 19

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