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Wyszukujesz frazę ""Doxorubicin"" wg kryterium: Temat


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Tytuł :
Redirecting Cisplatin and Doxorubicin to Mitochondria Affords Highly Effective Platinum Prodrug Against Triple Negative Breast Cancer.
Autorzy :
Muhammad N; School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
Cai-Ping T; School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
Nasreen S; Department of Environmental Engineering, University of Engineering and Technology (UET), Taxila, Taxila, 47080, Pakistan.
Mao ZW; School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
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Źródło :
Chemistry, an Asian journal [Chem Asian J] 2021 Aug 16; Vol. 16 (16), pp. 2276-2279. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article
MeSH Terms :
Cisplatin/*pharmacokinetics
Doxorubicin/*pharmacokinetics
Mitochondria/*metabolism
Triple Negative Breast Neoplasms/*drug therapy
Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cisplatin/chemistry ; Cisplatin/pharmacology ; DNA, Mitochondrial/drug effects ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Humans ; Mitochondria/drug effects ; Molecular Structure ; Molecular Targeted Therapy ; Prodrugs/chemical synthesis ; Prodrugs/pharmacokinetics ; Prodrugs/pharmacology
Czasopismo naukowe
Tytuł :
Doxorubicin-loaded natural daptomycin micelles with enhanced targeting and anti-tumor effect in vivo.
Autorzy :
Guo Q; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China; State Key Laboratory of Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, China.
Zhang L; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China.
He M; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China.
Jiang X; Hebei Key Laboratory for Chronic Diseases, School of Basic Medicine, North China University of Science and Technology, Tangshan, 063210, China.
Tian J; Hebei Key Laboratory for Chronic Diseases, School of Basic Medicine, North China University of Science and Technology, Tangshan, 063210, China.
Li Q; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China.
Liu Z; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China.
Wang L; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China; State Key Laboratory of Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, China. Electronic address: .
Sun H; Ocean NanoTech, LLC, San Diego, CA, 92126, USA. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113582. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Antibiotics, Antineoplastic/*pharmacology
Biological Products/*pharmacology
Daptomycin/*pharmacology
Doxorubicin/*pharmacology
Animals ; Anti-Bacterial Agents/chemistry ; Antibiotics, Antineoplastic/chemistry ; Biological Products/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Daptomycin/chemistry ; Dose-Response Relationship, Drug ; Doxorubicin/chemistry ; Drug Screening Assays, Antitumor ; Escherichia coli/drug effects ; Humans ; Mice ; Micelles ; Molecular Structure ; Staphylococcus aureus/drug effects ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Novel in vivo potential of trifluoperazine to ameliorate doxorubicin-induced cardiotoxicity involves suppression of NF-κB and apoptosis.
Autorzy :
Goda AE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Egypt. Electronic address: .
Elenany AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Egypt.
Elsisi AE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Egypt.
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Źródło :
Life sciences [Life Sci] 2021 Oct 15; Vol. 283, pp. 119849. Date of Electronic Publication: 2021 Jul 31.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiotoxicity*/drug therapy
Cardiotoxicity*/metabolism
Cardiotoxicity*/pathology
Apoptosis/*drug effects
Cardiotoxins/*adverse effects
Doxorubicin/*adverse effects
Myocardium/*metabolism
Transcription Factor RelA/*metabolism
Trifluoperazine/*pharmacology
Animals ; Cardiotoxins/pharmacology ; Caspase 3/metabolism ; Doxorubicin/pharmacology ; Male ; Mice ; Myocardium/pathology
Czasopismo naukowe
Tytuł :
Delivery of doxorubicin loaded P18 conjugated-poly(2-ethyl-oxazoline)-DOPE nanoliposomes for targeted therapy of breast cancer.
Autorzy :
Bolat ZB; Yeditepe University, Faculty of Engineering, Department of Genetics and Bioengineering, Atasehir, 34755 Istanbul, Turkey; Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Istanbul Sabahattin Zaim University, Kucukcekmece, 34303 Istanbul, Turkey.
Nezir AE; Yeditepe University, Faculty of Engineering, Department of Genetics and Bioengineering, Atasehir, 34755 Istanbul, Turkey.
Devrim B; Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Yeni mahalle, 06560 Ankara, Turkey.
Zemheri E; University of Health Sciences, Department of Pathology, Umraniye Training and Research Hospital, Umraniye, Istanbul, Turkey.
Gulyuz S; Materials Institute, Marmara Research Center, TUBITAK, Gebze, 41470 Kocaeli, Turkey; Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Maslak, 34469 Istanbul, Turkey.
Ozkose UU; Materials Institute, Marmara Research Center, TUBITAK, Gebze, 41470 Kocaeli, Turkey; Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Maslak, 34469 Istanbul, Turkey; Department of Chemistry, Faculty of Science and Letters, Piri Reis University, Tuzla, 34940 Istanbul, Turkey.
Yilmaz O; Materials Institute, Marmara Research Center, TUBITAK, Gebze, 41470 Kocaeli, Turkey.
Bozkir A; Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Yeni mahalle, 06560 Ankara, Turkey.
Telci D; Yeditepe University, Faculty of Engineering, Department of Genetics and Bioengineering, Atasehir, 34755 Istanbul, Turkey. Electronic address: .
Sahin F; Yeditepe University, Faculty of Engineering, Department of Genetics and Bioengineering, Atasehir, 34755 Istanbul, Turkey. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Oct 01; Vol. 428, pp. 115671. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*drug therapy
Doxorubicin/*administration & dosage
Drug Delivery Systems/*methods
Nanoparticles/*administration & dosage
Phosphatidylethanolamines/*administration & dosage
Polyamines/*administration & dosage
Animals ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Doxorubicin/pharmacokinetics ; Female ; Liposomes ; Mice ; Mice, Nude ; Nanoparticles/metabolism ; Peptide Fragments/administration & dosage ; Peptide Fragments/pharmacokinetics ; Phosphatidylethanolamines/pharmacokinetics ; Polyamines/pharmacokinetics ; Tumor Burden/drug effects ; Tumor Burden/physiology
Czasopismo naukowe
Tytuł :
Protective effect of valsartan against doxorubicin-induced cardiotoxicity: Histopathology and metabolomics in vivo study.
Autorzy :
Alhazzani K; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alotaibi MR; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alotaibi FN; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Aljerian K; Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
As Sobeai HM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alhoshani AR; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alanazi AZ; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alanazi WA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alswayyed M; Department of Pathology and Laboratory Medicine, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Sep; Vol. 35 (9), pp. e22842. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiotoxicity*/metabolism
Cardiotoxicity*/pathology
Cardiotoxicity*/prevention & control
Metabolomics*
Cardiotonic Agents/*pharmacology
Doxorubicin/*administration & dosage
Valsartan/*pharmacology
Animals ; Doxorubicin/pharmacology ; Gene Expression Regulation/drug effects ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Trehalose alleviates doxorubicin-induced cardiotoxicity in female Swiss albino mice by suppression of oxidative stress and autophagy.
Autorzy :
Abu-Khudir R; Chemistry Department, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.; Chemistry Department, Biochemistry Branch, Faculty of Science, Tanta University, Tanta, Egypt.
Ibrahim WM; Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt.
Shams ME; Chemistry Department, Biochemistry Branch, Faculty of Science, Tanta University, Tanta, Egypt.
Salama AF; Chemistry Department, Biochemistry Branch, Faculty of Science, Tanta University, Tanta, Egypt.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Sep; Vol. 35 (9), pp. e22859. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy/*drug effects
Cardiotonic Agents/*pharmacology
Cardiotoxicity/*drug therapy
Doxorubicin/*adverse effects
Oxidative Stress/*drug effects
Trehalose/*pharmacology
Animals ; Biomarkers/metabolism ; Cardiotoxicity/metabolism ; Doxorubicin/pharmacology ; Female ; Mice ; Myocardium/metabolism
Czasopismo naukowe
Tytuł :
The prognosis of cancer patients undergoing liposomal doxorubicin-based chemotherapy: A systematic review and meta-analysis.
Autorzy :
Zhang KP; Department of Urology, Anhui Provincial Children's Hospital and Children's Hospital of Anhui Medical University, Hefei, Anhui, P. R. China.
Fang X
Zhang Y
Chao M
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Aug 27; Vol. 100 (34), pp. e26690.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Antibiotics, Antineoplastic/*therapeutic use
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Doxorubicin/*analogs & derivatives
Neoplasms/*drug therapy
Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/adverse effects ; Doxorubicin/administration & dosage ; Doxorubicin/adverse effects ; Doxorubicin/therapeutic use ; Humans ; Multicenter Studies as Topic ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/adverse effects ; Polyethylene Glycols/therapeutic use ; Proportional Hazards Models ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
Doxorubicin Paradoxically Ameliorates Tumor-Induced Inflammation in Young Mice.
Autorzy :
Abdelgawad IY; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Grant MKO; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Popescu FE; Department of Pediatrics, Genetics, Cell Biology and Development, Masonic Cancer Center, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Largaespada DA; Department of Pediatrics, Genetics, Cell Biology and Development, Masonic Cancer Center, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Zordoky BN; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 21; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*therapeutic use
Doxorubicin/*therapeutic use
Inflammation/*drug therapy
Lymphoma/*drug therapy
Animals ; Antibiotics, Antineoplastic/pharmacology ; Biomarkers/metabolism ; Cell Line, Tumor ; Cytokines/blood ; Doxorubicin/pharmacology ; Drug Screening Assays, Antitumor ; Heart/drug effects ; Inflammation/blood ; Inflammation/etiology ; Kidney/drug effects ; Kidney/metabolism ; Liver/drug effects ; Liver/metabolism ; Lymphoma/complications ; Male ; Mice ; Mice, Inbred C57BL ; Myocardium/metabolism
Czasopismo naukowe
Tytuł :
Chlorogenic Acid Enhances Doxorubicin-Mediated Cytotoxic Effect in Osteosarcoma Cells.
Autorzy :
Salzillo A; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, 80138 Naples, Italy.
Ragone A; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, 80138 Naples, Italy.
Spina A; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, 80138 Naples, Italy.
Naviglio S; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, 80138 Naples, Italy.
Sapio L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, 80138 Naples, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 10; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*pathology
Chlorogenic Acid/*pharmacology
Doxorubicin/*pharmacology
Osteosarcoma/*pathology
Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bone Neoplasms/drug therapy ; Cardiotonic Agents/pharmacology ; Cell Death/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Chlorogenic Acid/administration & dosage ; Doxorubicin/administration & dosage ; Drug Synergism ; Humans ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/physiology ; Osteosarcoma/drug therapy ; Rats
Czasopismo naukowe
Tytuł :
Cytosine-Rich DNA Fragments Covalently Bound to Carbon Nanotube as Factors Triggering Doxorubicin Release at Acidic pH. A Molecular Dynamics Study.
Autorzy :
Wolski P; Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, ul. Niezapominajek 8, 30239 Cracow, Poland.
Nieszporek K; Department of Theoretical Chemistry, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University in Lublin, pl. Maria Curie-Sklodowska 3, 20031 Lublin, Poland.
Panczyk T; Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, ul. Niezapominajek 8, 30239 Cracow, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 06; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*administration & dosage
Cytosine/*analogs & derivatives
Delayed-Action Preparations/*chemistry
Doxorubicin/*administration & dosage
Nanotubes, Carbon/*chemistry
Antibiotics, Antineoplastic/chemistry ; DNA/chemistry ; Doxorubicin/chemistry ; Drug Liberation ; Hydrogen-Ion Concentration ; Molecular Dynamics Simulation
Czasopismo naukowe
Tytuł :
Construction of hyperbranched and pH-responsive polymeric nanocarriers by yne-phenol click-reaction for tumor synergistic chemotherapy.
Autorzy :
Zhang N; School of Chemistry, MOE Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiaotong University, Xi'an, 710049, PR China.
Wang D; School of Chemistry, MOE Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiaotong University, Xi'an, 710049, PR China. Electronic address: .
Yang T; School of Chemistry, MOE Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiaotong University, Xi'an, 710049, PR China.
Jing X; Talent Highland, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, PR China.
Meng L; School of Chemistry, MOE Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiaotong University, Xi'an, 710049, PR China; Instrumental Analysis Center, Xi'an Jiaotong University, Xi'an, 710049, PR China. Electronic address: .
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2021 Aug; Vol. 204, pp. 111790. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article
MeSH Terms :
Doxorubicin*/pharmacology
Phenol*
Cell Line, Tumor ; Drug Delivery Systems ; Hydrogen-Ion Concentration ; Polyethylene Glycols ; Polymers
Czasopismo naukowe
Tytuł :
Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF-κB intricate network in experimentally doxorubicin-induced cardiotoxicity in rats: The role of curcumin.
Autorzy :
Soliman NA; Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt.
Abo El Gheit RE; Department of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Abdel Ghafar MT; Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt.
AbuoHashish NA; Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Ibrahim MAA; Department of Histology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Abo Safia HS; Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt.
El-Saka MH; Department of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Elshamy AM; Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Aug; Vol. 35 (8), pp. e22829. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiotoxicity*/metabolism
Cardiotoxicity*/prevention & control
Curcumin/*pharmacology
Cytokine TWEAK/*metabolism
Doxorubicin/*adverse effects
NF-kappa B/*metabolism
Signal Transduction/*drug effects
TWEAK Receptor/*metabolism
rac1 GTP-Binding Protein/*metabolism
Animals ; Doxorubicin/pharmacology ; Male ; Rats
Czasopismo naukowe
Tytuł :
8-Formylophiopogonanone B antagonizes doxorubicin-induced cardiotoxicity by suppressing heme oxygenase-1-dependent myocardial inflammation and fibrosis.
Autorzy :
Qin D; Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, No. 63, Wenhua Road, Shunqing District, Nanchong, Sichuan 637000, China.
Yue R; Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, No. 63, Wenhua Road, Shunqing District, Nanchong, Sichuan 637000, China.
Deng P; Department of Occupational Health, Third Military Medical University, Chongqing 400038, China.
Wang X; Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, No. 63, Wenhua Road, Shunqing District, Nanchong, Sichuan 637000, China.
Zheng Z; Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, No. 63, Wenhua Road, Shunqing District, Nanchong, Sichuan 637000, China.
Lv M; Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, No. 63, Wenhua Road, Shunqing District, Nanchong, Sichuan 637000, China.
Zhang Y; Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.
Pu J; Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, No. 63, Wenhua Road, Shunqing District, Nanchong, Sichuan 637000, China.
Xu J; Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.
Liang Y; School of Medicine, Guangxi University, Nanning, Guangxi Zhuang Autonomous Region 530004, China.
Pi H; Academician Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China; Department of Occupational Health, Third Military Medical University, Chongqing 400038, China.
Yu Z; Department of Occupational Health, Third Military Medical University, Chongqing 400038, China.
Hu H; Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, No. 63, Wenhua Road, Shunqing District, Nanchong, Sichuan 637000, China; Academician Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Aug; Vol. 140, pp. 111779. Date of Electronic Publication: 2021 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*
Doxorubicin*
Cardiotonic Agents/*therapeutic use
Cardiotoxicity/*drug therapy
Heme Oxygenase-1/*antagonists & inhibitors
Isoflavones/*therapeutic use
Membrane Proteins/*antagonists & inhibitors
Animals ; Cardiotonic Agents/pharmacology ; Cardiotoxicity/genetics ; Cardiotoxicity/metabolism ; Cardiotoxicity/pathology ; Cytokines/genetics ; Fibrosis ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Inflammation/drug therapy ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Isoflavones/pharmacology ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Myocardium/metabolism ; Myocardium/pathology
Czasopismo naukowe
Tytuł :
Doxorubicin induces arterial stiffness: A comprehensive in vivo and ex vivo evaluation of vascular toxicity in mice.
Autorzy :
Bosman M; University of Antwerp, Faculty of Medicine and Health Sciences, Laboratory of Physiopharmacology, Campus Drie Eiken, Universiteitsplein 1, B-2610, Antwerp, Belgium. Electronic address: .
Favere K; University of Antwerp, Faculty of Medicine and Health Sciences, Laboratory of Physiopharmacology, Campus Drie Eiken, Universiteitsplein 1, B-2610, Antwerp, Belgium; University of Antwerp, Research Group Cardiovascular Diseases, GENCOR, Antwerp, Belgium; Ghent University, Faculty of Medicine and Health Sciences, Department of Internal Medicine, C. Heymanslaan 10, B-9000, Ghent, Belgium; Antwerp University Hospital (UZA), Department of Cardiology, Drie Eikenstraat 655, B-2650, Edegem, Belgium.
Neutel CHG; University of Antwerp, Faculty of Medicine and Health Sciences, Laboratory of Physiopharmacology, Campus Drie Eiken, Universiteitsplein 1, B-2610, Antwerp, Belgium.
Jacobs G; University of Antwerp, Faculty of Medicine and Health Sciences, Laboratory of Physiopharmacology, Campus Drie Eiken, Universiteitsplein 1, B-2610, Antwerp, Belgium.
De Meyer GRY; University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Physiopharmacology, Campus Drie Eiken, Universiteitsplein 1, B-2610, Antwerp, Belgium.
Martinet W; University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Physiopharmacology, Campus Drie Eiken, Universiteitsplein 1, B-2610, Antwerp, Belgium.
Van Craenenbroeck EM; University of Antwerp, Research Group Cardiovascular Diseases, GENCOR, Antwerp, Belgium; Antwerp University Hospital (UZA), Department of Cardiology, Drie Eikenstraat 655, B-2650, Edegem, Belgium.
Guns PDF; University of Antwerp, Faculty of Medicine and Health Sciences, Laboratory of Physiopharmacology, Campus Drie Eiken, Universiteitsplein 1, B-2610, Antwerp, Belgium.
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Aug 01; Vol. 346, pp. 23-33. Date of Electronic Publication: 2021 Apr 22.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*toxicity
Doxorubicin/*toxicity
Vascular Stiffness/*drug effects
Animals ; Aorta/drug effects ; Aorta/pathology ; Doxorubicin/administration & dosage ; Drug Tapering ; Endothelial Cells/drug effects ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Nitric Oxide/metabolism ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
Targeted doxorubicin delivery and release within breast cancer environment using PEGylated chitosan nanoparticles labeled with monoclonal antibodies.
Autorzy :
Helmi O; Department of Chemistry, School of Sciences and Engineering, The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo 11835, Egypt. Electronic address: .
Elshishiny F; Department of Chemistry, School of Sciences and Engineering, The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo 11835, Egypt. Electronic address: .
Mamdouh W; Department of Chemistry, School of Sciences and Engineering, The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo 11835, Egypt. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 01; Vol. 184, pp. 325-338. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal/*pharmacology
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*metabolism
Chitosan/*chemistry
Doxorubicin/*pharmacology
Polyethylene Glycols/*chemistry
Animals ; Antibodies, Monoclonal/chemistry ; Antineoplastic Agents/chemistry ; Breast Neoplasms/drug therapy ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Delayed-Action Preparations ; Dose-Response Relationship, Drug ; Doxorubicin/chemistry ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Hydrogen-Ion Concentration ; MCF-7 Cells ; Mammaglobin A/antagonists & inhibitors ; Mice ; Nanoparticles ; Receptor, ErbB-2/antagonists & inhibitors ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
Comparison of CHOP with THP-COP for peripheral T-cell lymphoma-not otherwise specified and angioimmunoblastic T-cell lymphoma: a retrospective analysis using data from the population-based Osaka Cancer Registry.
Autorzy :
Kida S; Department of Hematology, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka-shi, Osaka, 5418567, Japan.
Fuji S; Department of Hematology, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka-shi, Osaka, 5418567, Japan. .
Morishima T; Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.
Nakata K; Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.
Miyashiro I; Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.
Ishikawa J; Department of Hematology, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka-shi, Osaka, 5418567, Japan.
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Źródło :
International journal of hematology [Int J Hematol] 2021 Aug; Vol. 114 (2), pp. 246-251. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Doxorubicin/*analogs & derivatives
Lymphoma, T-Cell, Peripheral/*drug therapy
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Combined Modality Therapy/adverse effects ; Combined Modality Therapy/methods ; Cyclophosphamide/adverse effects ; Cyclophosphamide/therapeutic use ; Disease Management ; Doxorubicin/adverse effects ; Doxorubicin/therapeutic use ; Female ; Health Care Surveys ; Hospitalization ; Humans ; Japan/epidemiology ; Lymphoma, T-Cell, Peripheral/diagnosis ; Lymphoma, T-Cell, Peripheral/epidemiology ; Male ; Middle Aged ; Prednisolone/adverse effects ; Prednisolone/therapeutic use ; Prednisone/adverse effects ; Prednisone/therapeutic use ; Prognosis ; Registries ; Retrospective Studies ; Treatment Outcome ; Vincristine/adverse effects ; Vincristine/therapeutic use
SCR Protocol :
CHOP protocol; VEP-THP protocol
Czasopismo naukowe
Tytuł :
Resveratrol significantly improves cell survival in comparison to dexrazoxane and carvedilol in a h9c2 model of doxorubicin induced cardiotoxicity.
Autorzy :
Monahan DS; Anatomy & Regenerative Medicine Institute, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland; Centre for Research in Medical Devices (CύRAM), National University of Ireland Galway, Galway, Ireland. Electronic address: .
Flaherty E; Anatomy & Regenerative Medicine Institute, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland. Electronic address: .
Hameed A; Tissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, Dublin 2, Dublin, Ireland; Trinity Centre for Biomedical Engineering (TCBE), Trinity College Dublin (TCD), Dublin, Ireland. Electronic address: .
Duffy GP; Anatomy & Regenerative Medicine Institute, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland; Centre for Research in Medical Devices (CύRAM), National University of Ireland Galway, Galway, Ireland; Tissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, Dublin 2, Dublin, Ireland; Advanced Materials and BioEngineering Research (AMBER), Trinity College Dublin & National University of Ireland Galway, Ireland. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Aug; Vol. 140, pp. 111702. Date of Electronic Publication: 2021 May 17.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Antibiotics, Antineoplastic*
Doxorubicin*
Cardiotonic Agents/*pharmacology
Cardiotoxicity/*drug therapy
Resveratrol/*pharmacology
Animals ; Carvedilol/pharmacology ; Cell Line ; Cell Survival/drug effects ; Dexrazoxane/pharmacology ; Rats ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Zwitterionic nanogels with temperature sensitivity and redox-degradability for controlled drug release.
Autorzy :
Lei M; School of Materials Science and Engineering, Chang'an University, Xi'an, Shaanxi, 710064, PR China.
Zhang W; School of Materials Science and Engineering, Chang'an University, Xi'an, Shaanxi, 710064, PR China.
Yi C; School of Materials Science and Engineering, Chang'an University, Xi'an, Shaanxi, 710064, PR China.
Yan L; School of Materials Science and Engineering, Chang'an University, Xi'an, Shaanxi, 710064, PR China; Engineering Research Central of Pavement Materials, Ministry of Education of PR China, Chang'an University, Xi'an, 710064, PR China.
Tian Y; School of Materials Science and Engineering, Chang'an University, Xi'an, Shaanxi, 710064, PR China; Engineering Research Central of Pavement Materials, Ministry of Education of PR China, Chang'an University, Xi'an, 710064, PR China. Electronic address: .
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2021 Oct; Vol. 206, pp. 111959. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Doxorubicin*/pharmacology
Drug Carriers*
Drug Liberation ; HeLa Cells ; Humans ; Nanogels ; Oxidation-Reduction ; Temperature
Czasopismo naukowe
Tytuł :
EDTA-Gradient Loading of Doxorubicin into Ferrocene-Containing Liposomes: Effect of Lipid Composition and Visualization of Triggered Release by Cryo-TEM.
Autorzy :
Odette WL; Department of Chemistry, McGill University, 801 Sherbrooke West, Montreal, Quebec H3A 0B8, Canada.
Hennecker CD; Department of Chemistry, McGill University, 801 Sherbrooke West, Montreal, Quebec H3A 0B8, Canada.
Mittermaier AK; Department of Chemistry, McGill University, 801 Sherbrooke West, Montreal, Quebec H3A 0B8, Canada.
Mauzeroll J; Department of Chemistry, McGill University, 801 Sherbrooke West, Montreal, Quebec H3A 0B8, Canada.
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Źródło :
Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2021 Sep 28; Vol. 37 (38), pp. 11222-11232. Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Doxorubicin*
Liposomes*
Drug Delivery Systems ; Edetic Acid ; Humans ; Lipids ; Metallocenes
Czasopismo naukowe
Tytuł :
Dual responsive dextran-graft-poly (N-isopropylacrylamide)/doxorubicin prodrug via Schiff base reaction.
Autorzy :
Carneiro MJM; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Brazil.
Paula CBA; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Brazil.
Ribeiro IS; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Brazil.
de Lima LRM; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Brazil.
Ribeiro FOS; Research Center on Biodiversity and Biotechnology, BIOTEC, Federal University of Delta of Parnaíba, UFDPar, Parnaíba, PI, Brazil.
Silva DA; Research Center on Biodiversity and Biotechnology, BIOTEC, Federal University of Delta of Parnaíba, UFDPar, Parnaíba, PI, Brazil.
Araújo GS; Cell Culture Laboratory of the Delta, LCC Delta, Federal University of Delta of Parnaíba, UFDPar, Parnaíba, PI, Brazil.
Marinho Filho JDB; Cell Culture Laboratory of the Delta, LCC Delta, Federal University of Delta of Parnaíba, UFDPar, Parnaíba, PI, Brazil.
Araújo AJ; Cell Culture Laboratory of the Delta, LCC Delta, Federal University of Delta of Parnaíba, UFDPar, Parnaíba, PI, Brazil.
Freire RS; Department of Physics, Federal University of Ceará, 60440-900 Fortaleza, Brazil.
Feitosa JPA; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Brazil.
de Paula RCM; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Brazil. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 390-402. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Acrylamides/*chemistry
Dextrans/*chemistry
Doxorubicin/*pharmacology
Prodrugs/*pharmacology
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Doxorubicin/chemistry ; HCT116 Cells ; Humans ; Hydrogen-Ion Concentration ; Mice ; Micelles ; Prodrugs/chemistry ; Schiff Bases/chemistry
Czasopismo naukowe

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