Corrination mitigates peptide aggregation as exemplified for Glucagon.
Autorzy:
Liles A; Department of Chemistry, Syracuse University, Syracuse, NY 13244, United States. Cham N; Department of Chemistry, Syracuse University, Syracuse, NY 13244, United States. Opp ML; Department of Chemistry, Syracuse University, Syracuse, NY 13244, United States. Tinsley IC; Department of Chemistry, Syracuse University, Syracuse, NY 13244, United States. Chepurny OG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, United States. Holz GG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, United States; Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, United States. DoyleRP; Department of Chemistry, Syracuse University, Syracuse, NY 13244, United States; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, United States; Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, United States. Electronic address: .
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Peptides [Peptides] 2024 Jan; Vol. 171, pp. 171134. Date of Electronic Publication: 2023 Dec 12.
Creation of a Peptide Antagonist of the GFRAL-RET Receptor Complex for the Treatment of GDF15-Induced Malaise.
Autorzy:
Borner T; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States. Tinsley IC; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States. Milliken BT; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States. Doebley SA; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States. Najjar NR; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States. Kerwood DJ; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States. De Jonghe BC; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States. Hayes MR; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States. DoyleRP; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.; Departments of Medicine and Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13245, United States.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2023 Aug 24; Vol. 66 (16), pp. 11237-11249. Date of Electronic Publication: 2023 Jul 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Rapid, green disulphide bond formation in water using the corrin dicyanocobinamide.
Autorzy:
Spear A; Department of Chemistry, Syracuse University, Syracuse, New York 13244, USA. . Orativskyi O; Department of Chemistry, Syracuse University, Syracuse, New York 13244, USA. . Tran S; Department of Chemistry, Syracuse University, Syracuse, New York 13244, USA. . Zubieta JA; Department of Chemistry, Syracuse University, Syracuse, New York 13244, USA. . DoyleRP; Department of Chemistry, Syracuse University, Syracuse, New York 13244, USA. .; Department of Medicine, State University of New York Upstate Medical University, Syracuse, New York, USA.; Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York, USA.
A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss.
Autorzy:
Chichura KS; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA. Elfers CT; Seattle Children's Research Institute, 1900 Ninth Ave, Seattle, WA, 98101, USA. Salameh TS; Seattle Children's Research Institute, 1900 Ninth Ave, Seattle, WA, 98101, USA. Kamat V; Diabetes Research Institute and Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA, 98195, USA. Chepurny OG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA. McGivney A; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA. Milliken BT; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA. Holz GG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA.; Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA. Applebey SV; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Hayes MR; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Sweet IR; Diabetes Research Institute and Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA, 98195, USA. Roth CL; Seattle Children's Research Institute, 1900 Ninth Ave, Seattle, WA, 98101, USA. .; Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, 98105, USA. . DoyleRP; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA. .; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA. .; Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 12; Vol. 13 (1), pp. 9554. Date of Electronic Publication: 2023 Jun 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while CNS entry is required for locomotor and taste avoidance effects.
Autorzy:
Asker M; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for molecular and translational medicine, University of Gothenburg, Gothenburg, Sweden. Krieger JP; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. Liles A; Department of Chemistry, Syracuse University, Syracuse, New York, USA. Tinsley IC; Department of Chemistry, Syracuse University, Syracuse, New York, USA. Borner T; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Maric I; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Department of Chemistry, Syracuse University, Syracuse, New York, USA.; Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA. Doebley S; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA. Furst CD; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA. Börchers S; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for molecular and translational medicine, University of Gothenburg, Gothenburg, Sweden. Longo F; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. Bhat YR; Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA. De Jonghe BC; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Hayes MR; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. DoyleRP; Department of Chemistry, Syracuse University, Syracuse, New York, USA.; Departments of Medicine and Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York, USA. Skibicka KP; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for molecular and translational medicine, University of Gothenburg, Gothenburg, Sweden.; Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.
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Źródło:
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2023 Mar; Vol. 25 (3), pp. 856-877. Date of Electronic Publication: 2023 Jan 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Photocatalytic turnover of CO 2 under visible light by [Re(CO) 3 (1-(1,10) phenanthroline-5-(4-nitro-naphthalimide))Cl] in tandem with the sacrificial donor BIH.
Autorzy:
Spear A; Department of Chemistry, Syracuse University Syracuse NY 13244 USA . Schuarca RL; Department of Biomedical and Chemical Engineering, Syracuse University Syracuse NY 13244 USA. Bond JQ; Department of Biomedical and Chemical Engineering, Syracuse University Syracuse NY 13244 USA. Korter TM; Department of Chemistry, Syracuse University Syracuse NY 13244 USA . Zubieta J; Department of Chemistry, Syracuse University Syracuse NY 13244 USA . DoyleRP; Department of Chemistry, Syracuse University Syracuse NY 13244 USA .
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Źródło:
RSC advances [RSC Adv] 2022 Feb 10; Vol. 12 (9), pp. 5080-5084. Date of Electronic Publication: 2022 Feb 10 (Print Publication: 2022).
Single nuclei RNA sequencing of the rat AP and NTS following GDF15 treatment.
Autorzy:
Reiner BC; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: . Crist RC; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. Borner T; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biobehavioral Health Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. DoyleRP; Syracuse University, Department of Chemistry, 111 College Place, Syracuse, NY 13244, USA. Hayes MR; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biobehavioral Health Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. De Jonghe BC; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biobehavioral Health Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: .
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Źródło:
Molecular metabolism [Mol Metab] 2022 Feb; Vol. 56, pp. 101422. Date of Electronic Publication: 2021 Dec 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Glucagon-like peptide-1 in diabetes care: Can glycaemic control be achieved without nausea and vomiting?
Autorzy:
Borner T; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Tinsley IC; Department of Chemistry, Syracuse University, Syracuse, New York, USA. DoyleRP; Department of Chemistry, Syracuse University, Syracuse, New York, USA.; Department of Medicine, State University of New York Upstate Medical University, Syracuse, New York, USA.; Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York, USA. Hayes MR; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA. De Jonghe BC; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2022 Feb; Vol. 179 (4), pp. 542-556. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Synthesis, Characterization, and Cellular Uptake of a Glycylglycine Chelate of Magnesium.
Autorzy:
Case DR; 111 College Place, Department of Chemistry, Syracuse University, Syracuse, New York 13244, United States. Gonzalez R; Balchem Corporation, 52 Sunrise Park Road, New Hampton, New York 10958, United States. Zubieta J; 111 College Place, Department of Chemistry, Syracuse University, Syracuse, New York 13244, United States. DoyleRP; 111 College Place, Department of Chemistry, Syracuse University, Syracuse, New York 13244, United States.
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Źródło:
ACS omega [ACS Omega] 2021 Nov 30; Vol. 6 (49), pp. 33454-33461. Date of Electronic Publication: 2021 Nov 30 (Print Publication: 2021).
Synthesis, Characterization, and Cellular Uptake of Magnesium Maltol and Ethylmaltol Complexes.
Autorzy:
Case DR; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States. Gonzalez R; Balchem Corporation, 52 Sunrise Park Road, New Hampton, New York 10958, United States. Zubieta J; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States. DoyleRP; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.
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Źródło:
ACS omega [ACS Omega] 2021 Oct 28; Vol. 6 (44), pp. 29713-29723. Date of Electronic Publication: 2021 Oct 28 (Print Publication: 2021).
Synthesis and Chemical and Biological Evaluation of a Glycine Tripeptide Chelate of Magnesium.
Autorzy:
Case DR; Department of Chemistry, 111 College Place, Syracuse University, Syracuse, NY 13244, USA. Zubieta J; Department of Chemistry, 111 College Place, Syracuse University, Syracuse, NY 13244, USA. Gonzalez R; Balchem Corporation, 52 Sunrise Park Road, New Hampton, NY 10958, USA. DoyleRP; Department of Chemistry, 111 College Place, Syracuse University, Syracuse, NY 13244, USA.
Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4.
Autorzy:
Tinsley IC; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States. Borner T; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania 19104, United States. Swanson ML; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States. Chepurny OG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, United States. Doebley SA; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania 19104, United States. Kamat V; Department of Medicine, University of Washington, Medicine Diabetes Institute, Seattle, Washington 98109, United States. Sweet IR; Department of Medicine, University of Washington, Medicine Diabetes Institute, Seattle, Washington 98109, United States. Holz GG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, United States. Hayes MR; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States. De Jonghe BC; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania 19104, United States. DoyleRP; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, United States.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2021 Mar 25; Vol. 64 (6), pp. 3479-3492. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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