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Wyświetlanie 1-20 z 20
Tytuł :
Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.
Autorzy :
Shelkar GP; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Pavuluri R; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Gandhi PJ; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Ravikrishnan A; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Gawande DY; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Liu J; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Stairs DJ; Psychology, Creighton University, Omaha, NE, 68178, USA.
Ugale RR; Department of Pharmaceutical Sciences, R.T.M. Nagpur University, Nagpur, Maharashtra, 440033, India.
Dravid SM; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA. .
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Źródło :
Scientific reports [Sci Rep] 2019 May 20; Vol. 9 (1), pp. 7572. Date of Electronic Publication: 2019 May 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Deletion*
Receptors, N-Methyl-D-Aspartate/*genetics
Schizophrenia/*genetics
Animals ; Anxiety/genetics ; Depression/genetics ; Disease Models, Animal ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Schizophrenia/chemically induced
Czasopismo naukowe
Tytuł :
In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.
Autorzy :
Alsaad HA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA.
DeKorver NW; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA.
Mao Z; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA.
Dravid SM; Department of Pharmacology, Creighton University, Omaha, NE, USA.
Arikkath J; Department of Developmental Neuroscience, Monroe Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.
Monaghan DT; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA. .
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Źródło :
Neurochemical research [Neurochem Res] 2019 Jan; Vol. 44 (1), pp. 61-77. Date of Electronic Publication: 2018 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Interneurons/*metabolism
Neuroglia/*metabolism
RNA, Messenger/*biosynthesis
Receptors, N-Methyl-D-Aspartate/*biosynthesis
Telencephalon/*metabolism
Animals ; Gene Expression ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Protein Subunits/biosynthesis ; Protein Subunits/genetics ; RNA, Messenger/genetics ; Receptors, N-Methyl-D-Aspartate/genetics
Czasopismo naukowe
Tytuł :
Region-specific Expression of NMDA Receptor GluN2C Subunit in Parvalbumin-Positive Neurons and Astrocytes: Analysis of GluN2C Expression using a Novel Reporter Model.
Autorzy :
Ravikrishnan A; Department of Pharmacology, Creighton University, Omaha, NE 68178, USA.
Gandhi PJ; Department of Pharmacology, Creighton University, Omaha, NE 68178, USA.
Shelkar GP; Department of Pharmacology, Creighton University, Omaha, NE 68178, USA.
Liu J; Department of Pharmacology, Creighton University, Omaha, NE 68178, USA.
Pavuluri R; Department of Pharmacology, Creighton University, Omaha, NE 68178, USA.
Dravid SM; Department of Pharmacology, Creighton University, Omaha, NE 68178, USA. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2018 Jun 01; Vol. 380, pp. 49-62. Date of Electronic Publication: 2018 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Brain/*metabolism
Neurons/*metabolism
Receptors, N-Methyl-D-Aspartate/*biosynthesis
Animals ; Gene Knock-In Techniques/methods ; Green Fluorescent Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Models, Animal ; Parvalbumins/metabolism ; Receptors, N-Methyl-D-Aspartate/analysis
Czasopismo naukowe
Tytuł :
Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.
Autorzy :
Sapkota K; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
Irvine MW; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Fang G; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Burnell ES; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Bannister N; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Volianskis A; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK; Centre for Neuroscience and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK.
Culley GR; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
Dravid SM; Department of Pharmacology, Creighton University, Omaha, NE, USA.
Collingridge GL; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada.
Jane DE; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Monaghan DT; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2017 Oct; Vol. 125, pp. 64-79. Date of Electronic Publication: 2017 Jul 11.
Typ publikacji :
Journal Article
MeSH Terms :
Carboxylic Acids/*pharmacology
Excitatory Amino Acid Agents/*pharmacology
Naphthalenes/*pharmacology
Receptors, N-Methyl-D-Aspartate/*metabolism
Allosteric Regulation ; Animals ; CA1 Region, Hippocampal/drug effects ; CA1 Region, Hippocampal/metabolism ; Dose-Response Relationship, Drug ; Glutamic Acid/pharmacology ; Glycine/pharmacology ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; Mice ; Oocytes ; Patch-Clamp Techniques ; Protein Conformation/drug effects ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Receptors, N-Methyl-D-Aspartate/genetics ; Tissue Culture Techniques ; Transfection ; Xenopus laevis
Czasopismo naukowe
Tytuł :
A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors.
Autorzy :
Chopra DA; Department of Pharmacology, Creighton University, Omaha, NE, 68178, United States.
Sapkota K; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, United States.
Irvine MW; School of Physiology & Pharmacology, University of Bristol, Bristol, BS8 1TD, UK.
Fang G; School of Physiology & Pharmacology, University of Bristol, Bristol, BS8 1TD, UK.
Jane DE; School of Physiology & Pharmacology, University of Bristol, Bristol, BS8 1TD, UK.
Monaghan DT; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, United States.
Dravid SM; Department of Pharmacology, Creighton University, Omaha, NE, 68178, United States. .
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Źródło :
Scientific reports [Sci Rep] 2017 Jul 31; Vol. 7 (1), pp. 6933. Date of Electronic Publication: 2017 Jul 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Carboxylic Acids/*pharmacology
Naphthalenes/*pharmacology
Receptors, N-Methyl-D-Aspartate/*chemistry
Receptors, N-Methyl-D-Aspartate/*metabolism
Allosteric Regulation ; Animals ; Binding Sites ; Carboxylic Acids/chemistry ; Drug Synergism ; HEK293 Cells ; Humans ; Models, Molecular ; Molecular Docking Simulation ; Naphthalenes/chemistry ; Patch-Clamp Techniques ; Protein Conformation ; Xenopus
Czasopismo naukowe
Tytuł :
The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function.
Autorzy :
Gupta SC; Department of Pharmacology, Omaha, NE 68178, USA.
Ravikrishnan A; Department of Pharmacology, Omaha, NE 68178, USA.
Liu J; Department of Pharmacology, Omaha, NE 68178, USA.
Mao Z; Department of Pharmacology and Experimental Therapeutics, University of Nebraska-Medical Center, Omaha, NE, 68198, USA.
Pavuluri R; Department of Pharmacology, Omaha, NE 68178, USA.
Hillman BG; Department of Pharmacology, Omaha, NE 68178, USA.
Gandhi PJ; Department of Pharmacology, Omaha, NE 68178, USA.
Stairs DJ; Psychology, Creighton University, Omaha, NE 68178, USA.
Li M; Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Ugale RR; Department of Pharmaceutical Sciences, R.T.M. Nagpur University, Nagpur, Maharashtra 440033, India.
Monaghan DT; Department of Pharmacology and Experimental Therapeutics, University of Nebraska-Medical Center, Omaha, NE, 68198, USA.
Dravid SM; Department of Pharmacology, Omaha, NE 68178, USA.
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Źródło :
Scientific reports [Sci Rep] 2016 Dec 06; Vol. 6, pp. 38321. Date of Electronic Publication: 2016 Dec 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Action Potentials/*physiology
Cognition/*physiology
Prefrontal Cortex/*metabolism
Pyramidal Cells/*metabolism
Receptors, N-Methyl-D-Aspartate/*genetics
Action Potentials/drug effects ; Animals ; Cognition/drug effects ; Dendritic Spines/drug effects ; Dendritic Spines/metabolism ; Dendritic Spines/ultrastructure ; Dizocilpine Maleate/pharmacology ; Excitatory Amino Acid Antagonists/pharmacology ; Gene Expression Regulation ; Glutamate Decarboxylase/genetics ; Glutamate Decarboxylase/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microtomy ; Parvalbumins/metabolism ; Patch-Clamp Techniques ; Phencyclidine/pharmacology ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/pathology ; Prepulse Inhibition/drug effects ; Pyramidal Cells/drug effects ; Pyramidal Cells/pathology ; Receptors, N-Methyl-D-Aspartate/deficiency ; Reflex, Startle/drug effects ; Tissue Culture Techniques
Czasopismo naukowe
Tytuł :
Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-D-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu.
Autorzy :
Chopra DA; Department of Pharmacology, Creighton University, Omaha, Nebraska (D.A.C., S.M.D.); and Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska (D.T.M.).
Monaghan DT; Department of Pharmacology, Creighton University, Omaha, Nebraska (D.A.C., S.M.D.); and Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska (D.T.M.).
Dravid SM; Department of Pharmacology, Creighton University, Omaha, Nebraska (D.A.C., S.M.D.); and Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska (D.T.M.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2015 Oct; Vol. 88 (4), pp. 650-9. Date of Electronic Publication: 2015 Jul 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium/*metabolism
Extracellular Fluid/*metabolism
Intracellular Fluid/*metabolism
Nerve Tissue Proteins/*metabolism
Pregnenolone/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Extracellular Fluid/drug effects ; HEK293 Cells ; Humans ; Intracellular Fluid/drug effects ; Ion Channel Gating/drug effects ; Ion Channel Gating/physiology ; Nerve Tissue Proteins/agonists ; Nerve Tissue Proteins/antagonists & inhibitors ; Pregnenolone/pharmacology ; Receptors, N-Methyl-D-Aspartate/agonists ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity.
Autorzy :
Gupta SC; Department of Pharmacology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Yadav R; Department of Pharmacology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Pavuluri R; Department of Pharmacology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Morley BJ; Neurochemistry Laboratory, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68178, USA.
Stairs DJ; Department of Psychology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Dravid SM; Department of Pharmacology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2015 Jun; Vol. 93, pp. 274-84. Date of Electronic Publication: 2015 Feb 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebral Cortex/*cytology
Dendritic Spines/*physiology
Hippocampus/*cytology
Neurons/*ultrastructure
Receptors, AMPA/*metabolism
Receptors, Glutamate/*deficiency
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Animals, Newborn ; Cerebral Cortex/growth & development ; Dendritic Spines/ultrastructure ; Desipramine/pharmacology ; Enzyme Inhibitors/pharmacology ; Excitatory Amino Acid Antagonists/pharmacology ; Exploratory Behavior/physiology ; Glutamate Dehydrogenase ; Hippocampus/growth & development ; Mice ; Mice, Knockout ; Motor Activity/drug effects ; Neurons/drug effects ; Neurons/physiology ; Phenols/pharmacology ; Piperidines/pharmacology ; Receptors, Glutamate/genetics ; Serotonin Uptake Inhibitors/pharmacology ; Signal Transduction/drug effects ; Sodium Channel Blockers/pharmacology ; Swimming/psychology ; Tetrodotoxin/pharmacology
Czasopismo naukowe
Tytuł :
Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
Autorzy :
Park H
Han KS
Seo J
Lee J
Dravid SM
Woo J
Chun H
Cho S
Bae JY
An H
Koh W
Yoon BE
Berlinguer-Palmini R
Mannaioni G
Traynelis SF
Bae YC
Choi SY
Lee CJ
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Źródło :
Molecular brain [Mol Brain] 2015 Feb 03; Vol. 8, pp. 7. Date of Electronic Publication: 2015 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuronal Plasticity*
Astrocytes/*metabolism
Eye Proteins/*metabolism
Glutamic Acid/*metabolism
Hippocampus/*metabolism
Ion Channels/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Bestrophins ; CA1 Region, Hippocampal/metabolism ; CA1 Region, Hippocampal/ultrastructure ; Hippocampus/ultrastructure ; Humans ; Long-Term Potentiation ; Mice ; Models, Biological ; Receptor, PAR-1/metabolism ; Synapses/metabolism ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Effect of ifenprodil on GluN1/GluN2B N-methyl-D-aspartate receptor gating.
Autorzy :
Bhatt JM; Department of Pharmacology, Creighton University, School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA.
Prakash A
Suryavanshi PS
Dravid SM
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2013 Jan; Vol. 83 (1), pp. 9-21. Date of Electronic Publication: 2012 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Piperidines/*pharmacology
Receptors, N-Methyl-D-Aspartate/*physiology
Allosteric Regulation ; Animals ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; Ion Channel Gating ; Patch-Clamp Techniques ; Rats ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Recombinant Proteins/antagonists & inhibitors ; Time Factors
Czasopismo naukowe
Tytuł :
Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory.
Autorzy :
Hillman BG; Department of Pharmacology, Creighton University, Omaha, NE 68178, USA.
Gupta SC
Stairs DJ
Buonanno A
Dravid SM
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Źródło :
Neurobiology of learning and memory [Neurobiol Learn Mem] 2011 May; Vol. 95 (4), pp. 404-14. Date of Electronic Publication: 2011 Feb 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Association Learning/*physiology
Conditioning, Classical/*physiology
Fear/*physiology
Memory, Short-Term/*physiology
Receptors, N-Methyl-D-Aspartate/*physiology
Amygdala/physiology ; Analysis of Variance ; Animals ; Behavior, Animal/physiology ; Exploratory Behavior/physiology ; Gene Knock-In Techniques ; Male ; Maze Learning/physiology ; Mice ; Mice, Knockout ; Neural Pathways/physiology ; Neuronal Plasticity/physiology ; Protein Subunits ; Receptors, N-Methyl-D-Aspartate/genetics ; Thalamus/physiology ; beta-Galactosidase/genetics ; beta-Galactosidase/metabolism
Czasopismo naukowe
Tytuł :
Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons.
Autorzy :
George J; Department of Pharmacology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA.
Dravid SM
Prakash A
Xie J
Peterson J
Jabba SV
Baden DG
Murray TF
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2009 Mar 11; Vol. 29 (10), pp. 3288-301.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cerebral Cortex/*growth & development
Neurites/*physiology
Receptors, N-Methyl-D-Aspartate/*physiology
Sodium Channels/*metabolism
Animals ; Cells, Cultured ; Cerebral Cortex/drug effects ; Female ; Marine Toxins/pharmacology ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; Mice ; Neurites/drug effects ; Neurons/drug effects ; Neurons/physiology ; Oxocins/pharmacology ; Pregnancy ; Sodium Channel Agonists
Czasopismo naukowe
Tytuł :
Activation of recombinant NR1/NR2C NMDA receptors.
Autorzy :
Dravid SM; Department of Pharmacology, Emory University, Atlanta, GA 30322, USA. />Prakash A
Traynelis SF
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Źródło :
The Journal of physiology [J Physiol] 2008 Sep 15; Vol. 586 (18), pp. 4425-39. Date of Electronic Publication: 2008 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, N-Methyl-D-Aspartate/*physiology
Animals ; Calcium/metabolism ; Cell Line ; Humans ; Patch-Clamp Techniques ; Rats ; Recombinant Proteins/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block.
Autorzy :
Dravid SM; Department of Pharmacology, Emory University School of Medicine, Rollins Research Centre, 1510 Clifton Road, Atlanta, GA 30322-3090, USA. />Erreger K
Yuan H
Nicholson K
Le P
Lyuboslavsky P
Almonte A
Murray E
Mosely C
Barber J
French A
Balster R
Murray TF
Traynelis SF
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Źródło :
The Journal of physiology [J Physiol] 2007 May 15; Vol. 581 (Pt 1), pp. 107-28. Date of Electronic Publication: 2007 Feb 15.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protons*
Ion Channels/*antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Animals ; Cell Line ; Dizocilpine Maleate/pharmacology ; Electrophysiology ; Excitatory Amino Acid Antagonists/pharmacology ; Humans ; Hydrogen-Ion Concentration ; Ion Channel Gating ; Ion Channels/drug effects ; Ion Channels/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/drug effects ; Receptors, N-Methyl-D-Aspartate/physiology ; Recombinant Proteins/antagonists & inhibitors ; Stereoisomerism ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog.
Autorzy :
Erreger K; Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia 30322, USA. />Geballe MT
Dravid SM
Snyder JP
Wyllie DJ
Traynelis SF
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2005 Aug 24; Vol. 25 (34), pp. 7858-66.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Glutamic Acid/*analogs & derivatives
Glutamic Acid/*metabolism
Receptors, N-Methyl-D-Aspartate/*agonists
Receptors, N-Methyl-D-Aspartate/*metabolism
Amino Acid Sequence ; Animals ; Binding Sites/drug effects ; Binding Sites/physiology ; Cell Line ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Agonists/chemistry ; Excitatory Amino Acid Agonists/metabolism ; Excitatory Amino Acid Agonists/pharmacology ; Female ; Glutamic Acid/pharmacology ; Humans ; Molecular Sequence Data ; Protein Conformation ; Quinolinic Acids/chemistry ; Quinolinic Acids/metabolism ; Quinolinic Acids/pharmacology ; Receptors, N-Methyl-D-Aspartate/chemistry ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3.
Autorzy :
Yuan H; Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia 30322-3090, USA.
Erreger K
Dravid SM
Traynelis SF
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2005 Aug 19; Vol. 280 (33), pp. 29708-16. Date of Electronic Publication: 2005 Jun 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Ion Channel Gating/*physiology
Receptors, N-Methyl-D-Aspartate/*chemistry
Receptors, N-Methyl-D-Aspartate/*physiology
Allosteric Regulation ; Amino Acid Sequence ; Cell Line ; Conserved Sequence ; Dizocilpine Maleate/pharmacology ; Excitatory Amino Acid Antagonists/pharmacology ; Humans ; Membrane Proteins/chemistry ; Molecular Sequence Data ; Protein Structure, Tertiary ; Protein Subunits ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles.
Autorzy :
Erreger K; Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, GA 30322-3090, USA. />Dravid SM
Banke TG
Wyllie DJ
Traynelis SF
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Źródło :
The Journal of physiology [J Physiol] 2005 Mar 01; Vol. 563 (Pt 2), pp. 345-58. Date of Electronic Publication: 2005 Jan 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Ion Channel Gating/*physiology
Protein Subunits/*physiology
Receptors, N-Methyl-D-Aspartate/*physiology
Animals ; Cell Line ; Glutamic Acid/pharmacology ; Humans ; Kinetics ; Rats ; Signal Transduction ; Synapses/physiology
Czasopismo naukowe
Tytuł :
Brevetoxin augments NMDA receptor signaling in murine neocortical neurons.
Autorzy :
Dravid SM; College of Veterinary Medicine, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA.
Baden DG
Murray TF
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Źródło :
Brain research [Brain Res] 2005 Jan 07; Vol. 1031 (1), pp. 30-8.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System/*drug effects
Marine Toxins/*pharmacology
Neocortex/*cytology
Neurons/*metabolism
Oxocins/*pharmacology
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Calcium/metabolism ; Drug Synergism ; Enzyme Inhibitors/pharmacology ; Excitatory Amino Acid Agonists/pharmacology ; Female ; Mice ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; N-Methylaspartate/pharmacology ; Neurons/drug effects ; Phosphorylation ; Pregnancy ; Pyrimidines/pharmacology ; Sodium/metabolism ; Sodium Channels/metabolism ; Tyrosine/metabolism ; src-Family Kinases/antagonists & inhibitors ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł :
Protons trap NR1/NR2B NMDA receptors in a nonconducting state.
Autorzy :
Banke TG; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Dravid SM
Traynelis SF
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2005 Jan 05; Vol. 25 (1), pp. 42-51.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Protons*
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Binding Sites ; Cell Line ; Glutamic Acid/metabolism ; Glutamic Acid/pharmacology ; Glycine/metabolism ; Humans ; Hydrogen-Ion Concentration ; Ion Channel Gating/physiology ; Kinetics ; Models, Chemical ; Protein Conformation ; Rats ; Receptors, N-Methyl-D-Aspartate/drug effects ; Receptors, N-Methyl-D-Aspartate/physiology ; Recombinant Proteins/metabolism
Czasopismo naukowe
    Wyświetlanie 1-20 z 20

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