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Tytuł:
Intravenous recombinant cerebellin 1 treatment restores signalling by spinal glutamate delta 1 receptors and mitigates chronic pain.
Autorzy:
Sabnis SS; Department of Pharmacology and Neuroscience, Creighton University, Omaha, Nebraska, USA.
S Narasimhan KK; Department of Pharmacology and Neuroscience, Creighton University, Omaha, Nebraska, USA.
Chettiar PB; Department of Pharmacology and Neuroscience, Creighton University, Omaha, Nebraska, USA.
Gakare SG; Department of Pharmacology and Neuroscience, Creighton University, Omaha, Nebraska, USA.
Shelkar GP; Department of Pharmacology and Neuroscience, Creighton University, Omaha, Nebraska, USA.
Asati DG; Department of Pharmacology and Neuroscience, Creighton University, Omaha, Nebraska, USA.
Thakur SS; Department of Pharmacology and Neuroscience, Creighton University, Omaha, Nebraska, USA.
Dravid SM; Department of Pharmacology and Neuroscience, Creighton University, Omaha, Nebraska, USA.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2023 Dec 03. Date of Electronic Publication: 2023 Dec 03.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Glutamate delta-1 receptor regulates oligodendrocyte progenitor cell differentiation and myelination in normal and demyelinating conditions.
Autorzy:
Gakare SG; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, United States of America.
Bhatt JM; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, United States of America.
Narasimhan KKS; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, United States of America.
Dravid SM; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Nov 20; Vol. 18 (11), pp. e0294583. Date of Electronic Publication: 2023 Nov 20 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Oligodendrocyte Precursor Cells*/metabolism
Demyelinating Diseases*/chemically induced
Demyelinating Diseases*/metabolism
Mice ; Animals ; Myelin Sheath/metabolism ; Cuprizone ; Glutamic Acid/metabolism ; Mice, Knockout ; Oligodendroglia/metabolism ; Cell Differentiation/physiology ; Corpus Callosum/metabolism ; Receptors, Glutamate/metabolism ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł:
GluN2D Subunit in Parvalbumin Interneurons Regulates Prefrontal Cortex Feedforward Inhibitory Circuit and Molecular Networks Relevant to Schizophrenia.
Autorzy:
Gawande DY; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska.
S Narasimhan KK; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska. Electronic address: .
Shelkar GP; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska.
Pavuluri R; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska.
Stessman HAF; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska.
Dravid SM; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska. Electronic address: .
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Źródło:
Biological psychiatry [Biol Psychiatry] 2023 Aug 15; Vol. 94 (4), pp. 297-309. Date of Electronic Publication: 2023 Mar 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Parvalbumins*/metabolism
Schizophrenia*/genetics
Schizophrenia*/metabolism
Animals ; Mice ; Interneurons/physiology ; Mice, Knockout ; Nerve Tissue Proteins/metabolism ; Prefrontal Cortex/metabolism ; Receptor, ErbB-4/metabolism
Czasopismo naukowe
Tytuł:
GluN2D subunit-containing NMDA receptors regulate reticular thalamic neuron function and seizure susceptibility.
Autorzy:
Gawande DY; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA. Electronic address: .
Shelkar GP; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Narasimhan KKS; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Liu J; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Dravid SM; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA. Electronic address: .
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Źródło:
Neurobiology of disease [Neurobiol Dis] 2023 Jun 01; Vol. 181, pp. 106117. Date of Electronic Publication: 2023 Apr 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/metabolism
Thalamus*/metabolism
Animals ; Mice ; Neurons/metabolism ; Seizures/metabolism ; Synaptic Transmission ; Thalamic Nuclei/metabolism
Czasopismo naukowe
Tytuł:
Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1).
Autorzy:
Mehrotra S; Department of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE 68178, USA.; Omeros, Seattle, WA 98119, USA.
Pierce ML; Department of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE 68178, USA.; Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, IL 60515, USA.
Dravid SM; Department of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE 68178, USA.
Murray TF; Department of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE 68178, USA.
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Źródło:
Marine drugs [Mar Drugs] 2022 Aug 31; Vol. 20 (9). Date of Electronic Publication: 2022 Aug 31.
Typ publikacji:
Journal Article
MeSH Terms:
Neurons*/drug effects
Neurons*/metabolism
Receptors, N-Methyl-D-Aspartate*/metabolism
p21-Activated Kinases*/metabolism
Actin Depolymerizing Factors/metabolism ; Actins/metabolism ; Animals ; Calcium/metabolism ; Marine Toxins ; Mice ; N-Methylaspartate ; Neuronal Outgrowth ; Oxocins ; RNA, Small Interfering/metabolism ; Sodium/metabolism ; Sodium Channel Agonists/metabolism ; Voltage-Gated Sodium Channels/metabolism ; rho GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens.
Autorzy:
Shelkar GP; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, USA.
Gandhi PJ; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, USA.
Liu J; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, USA.
Dravid SM; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, USA.
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Źródło:
Science advances [Sci Adv] 2022 Jul 22; Vol. 8 (29), pp. eabo6574. Date of Electronic Publication: 2022 Jul 22.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Astrocytic NMDA Receptors in the Basolateral Amygdala Contribute to Facilitation of Fear Extinction.
Autorzy:
Shelkar GP; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.
Liu J; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.
Dravid SM; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.
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Źródło:
The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2021 Nov 12; Vol. 24 (11), pp. 907-919.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Amygdala/*drug effects
Astrocytes/*metabolism
Extinction, Psychological/*drug effects
Fear/*drug effects
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Basolateral Nuclear Complex/metabolism ; Conditioning, Psychological/drug effects ; Cycloserine/pharmacology ; Excitatory Amino Acid Agonists/pharmacology ; Mice ; Receptors, AMPA/metabolism ; Synaptic Transmission/drug effects ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism
Czasopismo naukowe
Tytuł:
Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain.
Autorzy:
Gandhi PJ; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Gawande DY; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Shelkar GP; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Gakare SG; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Kiritoshi T; Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Ji G; Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.; Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Misra B; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Pavuluri R; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Liu J; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Neugebauer V; Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.; Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.; Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Dravid SM; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
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Źródło:
Cells [Cells] 2021 Oct 03; Vol. 10 (10). Date of Electronic Publication: 2021 Oct 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Signal Transduction*
Central Amygdaloid Nucleus/*metabolism
Chronic Pain/*metabolism
Nerve Tissue Proteins/*metabolism
Receptors, Glutamate/*metabolism
Synapses/*metabolism
Animals ; Behavior, Animal ; Chronic Pain/complications ; Chronic Pain/physiopathology ; Disease Models, Animal ; Down-Regulation ; Female ; Inflammation/complications ; Inflammation/pathology ; Male ; Mice, Knockout ; Nociception/drug effects ; Rats ; Recombinant Proteins/pharmacology ; Synaptic Transmission ; Mice
Czasopismo naukowe
Tytuł:
Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.
Autorzy:
Gawande DY; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plaza, Omaha, NE, USA.
Shelkar GP; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plaza, Omaha, NE, USA.
Liu J; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plaza, Omaha, NE, USA.
Ayala AD; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plaza, Omaha, NE, USA.
Pavuluri R; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plaza, Omaha, NE, USA.
Choi D; Yerkes National Primate Research Center, Atlanta, GA, 30329, USA.; UDALL Center of Excellence for Parkinson's Disease, Atlanta, GA, 30329, USA.
Smith Y; Yerkes National Primate Research Center, Atlanta, GA, 30329, USA.; UDALL Center of Excellence for Parkinson's Disease, Atlanta, GA, 30329, USA.; Department of Neurology, Emory University, Atlanta, GA, 30329, USA.
Dravid SM; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plaza, Omaha, NE, USA. .
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Źródło:
Molecular neurobiology [Mol Neurobiol] 2021 Oct; Vol. 58 (10), pp. 4787-4801. Date of Electronic Publication: 2021 Jun 26.
Typ publikacji:
Journal Article
MeSH Terms:
Anxiety/*metabolism
Glutamate Dehydrogenase/*biosynthesis
Inhibitory Postsynaptic Potentials/*physiology
Neural Inhibition/*physiology
Nucleus Accumbens/*metabolism
Synaptic Transmission/*physiology
Animals ; Anxiety/genetics ; Excitatory Amino Acid Antagonists/pharmacology ; Glutamate Dehydrogenase/antagonists & inhibitors ; Glutamate Dehydrogenase/genetics ; Inhibitory Postsynaptic Potentials/drug effects ; Locomotion/drug effects ; Locomotion/physiology ; Male ; Mice ; Mice, Knockout ; Neural Inhibition/drug effects ; Nucleus Accumbens/drug effects ; Social Interaction/drug effects ; Synaptic Transmission/drug effects
Czasopismo naukowe
Tytuł:
Correction to: Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
Autorzy:
Park H; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.
Han KS; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.; Neuroscience Program, University of Science and Technology (UST), Daejeon, Korea.
Seo J; Department of Physiology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.
Lee J; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.
Dravid SM; Department of Pharmacology, Creighton University, Omaha, NE, USA.
Woo J; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.; Neuroscience Program, University of Science and Technology (UST), Daejeon, Korea.
Chun H; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.
Cho S; Department of Physiology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.
Bae JY; Department of Oral Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
An H; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.; KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea.
Koh W; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.; Neuroscience Program, University of Science and Technology (UST), Daejeon, Korea.
Yoon BE; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.; Department of Nanobiomedical Science, Dankook University, Cheonan, Korea.
Berlinguer-Palmini R; School of Electrical and Electronic Engineering, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Mannaioni G; Department of Pharmacology, University of Florence, Florence, Italy.
Traynelis SF; Department of Pharmacology, Emory University, Atlanta, GA, USA.
Bae YC; Department of Oral Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
Choi SY; Department of Physiology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea. .
Lee CJ; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea. .; Neuroscience Program, University of Science and Technology (UST), Daejeon, Korea. .; KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea. .
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Źródło:
Molecular brain [Mol Brain] 2021 Jun 29; Vol. 14 (1), pp. 103. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji:
Published Erratum
Tytuł:
Ultrastructural localization of glutamate delta 1 (GluD1) receptor immunoreactivity in the mouse and monkey striatum.
Autorzy:
Hoover AH; Yerkes National Primate Research Center, Atlanta, Georgia, USA.; UDALL Center of Excellence for Parkinson's Disease, Atlanta, Georgia, USA.
Pavuluri R; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.
Shelkar GP; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.
Dravid SM; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.
Smith Y; Yerkes National Primate Research Center, Atlanta, Georgia, USA.; UDALL Center of Excellence for Parkinson's Disease, Atlanta, Georgia, USA.; Department of Neurology, Emory University, Atlanta, Georgia, USA.
Villalba RM; Yerkes National Primate Research Center, Atlanta, Georgia, USA.; UDALL Center of Excellence for Parkinson's Disease, Atlanta, Georgia, USA.
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Źródło:
The Journal of comparative neurology [J Comp Neurol] 2021 May 01; Vol. 529 (7), pp. 1703-1718. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Corpus Striatum/*metabolism
Receptors, Glutamate/*metabolism
Animals ; Macaca mulatta ; Male ; Mice
Czasopismo naukowe
Tytuł:
Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.
Autorzy:
Liu J; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, United States of America.
Shelkar GP; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, United States of America.
Sarode LP; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra 440033, India.
Gawande DY; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, United States of America.
Zhao F; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Clausen RP; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Ugale RR; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra 440033, India.
Dravid SM; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, United States of America. Electronic address: .
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Źródło:
Neurobiology of disease [Neurobiol Dis] 2021 Mar; Vol. 150, pp. 105254. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Globus Pallidus/*metabolism
Movement/*physiology
Neurons/*metabolism
Parkinsonian Disorders/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Cycloserine/pharmacology ; Disease Models, Animal ; Globus Pallidus/cytology ; Mice ; Motor Activity ; Movement/drug effects ; Parkinsonian Disorders/physiopathology ; Parvalbumins/metabolism ; Patch-Clamp Techniques ; Receptors, N-Methyl-D-Aspartate/agonists ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Subthalamic Nucleus
Czasopismo naukowe
Tytuł:
Environmental enrichment increases cue-dependent freezing and behavioral despair but decreases anxiety-like behavior in rats.
Autorzy:
Stairs DJ; Creighton University Department of Psychological Science, United States of America. Electronic address: .
Chacho NM; Creighton University Department of Psychological Science, United States of America.
Wunsch C; Creighton University Department of Psychological Science, United States of America.
Pipitone L; Creighton University Department of Psychological Science, United States of America.
Dravid SM; Creighton University Department of Pharmacology and Neuroscience, United States of America.
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Źródło:
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2020 Sep; Vol. 196, pp. 172979. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anxiety*
Cues*
Behavior, Animal/*drug effects
Animals ; Conditioning, Classical/drug effects ; Fear/drug effects ; Male ; Midazolam/pharmacology ; Midazolam/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Stress Disorders, Post-Traumatic/drug therapy ; Stress Disorders, Post-Traumatic/psychology
Czasopismo naukowe
Tytuł:
HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture.
Autorzy:
Hu G; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA. .
Niu F; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Liao K; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Periyasamy P; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Sil S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Liu J; Department of Pharmacology, Creighton University, Omaha, NE, USA.
Dravid SM; Department of Pharmacology, Creighton University, Omaha, NE, USA.
Buch S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA. .
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Źródło:
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2020 Sep; Vol. 15 (3), pp. 538-553. Date of Electronic Publication: 2019 Aug 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Astrocytes/*drug effects
Astrocytes/*ultrastructure
Extracellular Vesicles/*metabolism
MicroRNAs/*toxicity
Synapses/*drug effects
tat Gene Products, Human Immunodeficiency Virus/*toxicity
Animals ; Cell Adhesion Molecules, Neuronal/metabolism ; Gene Targeting ; HIV Infections/metabolism ; Humans ; Macaca ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; Nerve Tissue Proteins/metabolism ; Neurons/metabolism ; Platelet-Derived Growth Factor/metabolism ; Simian Acquired Immunodeficiency Syndrome/metabolism ; Synapses/ultrastructure ; Up-Regulation
Czasopismo naukowe
Tytuł:
Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity.
Autorzy:
Liu J; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Shelkar GP; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Gandhi PJ; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Gawande DY; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Hoover A; Yerkes National Primate Research Center, Atlanta, GA 30329, USA; UDALL Center of Excellence for Parkinson's Disease, Atlanta, GA 30329, USA.
Villalba RM; Yerkes National Primate Research Center, Atlanta, GA 30329, USA; UDALL Center of Excellence for Parkinson's Disease, Atlanta, GA 30329, USA.
Pavuluri R; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Smith Y; Yerkes National Primate Research Center, Atlanta, GA 30329, USA; UDALL Center of Excellence for Parkinson's Disease, Atlanta, GA 30329, USA; Dept. Neurology, Emory University, Atlanta, GA 30329, USA.
Dravid SM; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA. Electronic address: .
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Źródło:
Neurobiology of disease [Neurobiol Dis] 2020 Apr; Vol. 137, pp. 104746. Date of Electronic Publication: 2020 Jan 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Behavior, Animal/*physiology
Corpus Striatum/*metabolism
Receptors, Glutamate/*metabolism
Thalamus/*metabolism
Animals ; Corpus Striatum/physiology ; Female ; Male ; Mice ; Neurogenesis/physiology ; Synapses/physiology ; Synaptic Transmission/physiology ; Thalamus/physiopathology
Czasopismo naukowe
Tytuł:
Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.
Autorzy:
Shelkar GP; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Pavuluri R; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Gandhi PJ; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Ravikrishnan A; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Gawande DY; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Liu J; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA.
Stairs DJ; Psychology, Creighton University, Omaha, NE, 68178, USA.
Ugale RR; Department of Pharmaceutical Sciences, R.T.M. Nagpur University, Nagpur, Maharashtra, 440033, India.
Dravid SM; Department of Pharmacology, Creighton University, Omaha, NE, 68178, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 May 20; Vol. 9 (1), pp. 7572. Date of Electronic Publication: 2019 May 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Gene Deletion*
Receptors, N-Methyl-D-Aspartate/*genetics
Schizophrenia/*genetics
Animals ; Anxiety/genetics ; Depression/genetics ; Disease Models, Animal ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Schizophrenia/chemically induced
Czasopismo naukowe
Tytuł:
A mouse model of seizures in anti-N-methyl-d-aspartate receptor encephalitis.
Autorzy:
Taraschenko O; Division of Epilepsy, Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska.
Fox HS; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska.
Pittock SJ; Laboratory Medicine and Pathology, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Zekeridou A; Laboratory Medicine and Pathology, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Gafurova M; College of Arts and Sciences, University of Nebraska Omaha, Omaha, Nebraska.
Eldridge E; Division of Epilepsy, Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska.
Liu J; Department of Pharmacology, Creighton University, Omaha, Nebraska.
Dravid SM; Department of Pharmacology, Creighton University, Omaha, Nebraska.
Dingledine R; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia.
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Źródło:
Epilepsia [Epilepsia] 2019 Mar; Vol. 60 (3), pp. 452-463. Date of Electronic Publication: 2019 Feb 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*complications
Seizures/*etiology
Animals ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/pathology ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/physiopathology ; Autoantibodies/pharmacology ; Brain/pathology ; Brain/physiopathology ; Disease Models, Animal ; Electroencephalography ; Male ; Mice ; Mice, Inbred C57BL ; Seizures/pathology ; Seizures/physiopathology
Czasopismo naukowe
Tytuł:
In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.
Autorzy:
Alsaad HA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA.
DeKorver NW; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA.
Mao Z; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA.
Dravid SM; Department of Pharmacology, Creighton University, Omaha, NE, USA.
Arikkath J; Department of Developmental Neuroscience, Monroe Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.
Monaghan DT; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, USA. .
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Źródło:
Neurochemical research [Neurochem Res] 2019 Jan; Vol. 44 (1), pp. 61-77. Date of Electronic Publication: 2018 Apr 12.
Typ publikacji:
Journal Article
MeSH Terms:
Interneurons/*metabolism
Neuroglia/*metabolism
RNA, Messenger/*biosynthesis
Receptors, N-Methyl-D-Aspartate/*biosynthesis
Telencephalon/*metabolism
Animals ; Gene Expression ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Protein Subunits/biosynthesis ; Protein Subunits/genetics ; RNA, Messenger/genetics ; Receptors, N-Methyl-D-Aspartate/genetics
Czasopismo naukowe

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