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Tytuł :
Revisiting the complexity of GLP-1 action-from sites of synthesis to receptor activation.
Autorzy :
McLean BA; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Wong CK; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Campbell JE; Department of Medicine, Division of Endocrinology, Department of Pharmacology and Cancer Biology, Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Hodson DJ; Institute of Metabolism and Systems Research (IMSR), University of Birmingham, and Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
Trapp S; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, UCL, London, UK.
Drucker DJ; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
Endocrine reviews [Endocr Rev] 2020 Dec 15. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
GLP-1 Receptor Signaling Differentially Modifies the Outcomes of Sterile vs Viral Pulmonary Inflammation in Male Mice.
Autorzy :
Sato T; Department of Endocrinology, Diabetes, and Geriatric Medicine, Akita University Graduate School of Medicine, Akita, Japan.
Shimizu T; Department of Endocrinology, Diabetes, and Geriatric Medicine, Akita University Graduate School of Medicine, Akita, Japan.
Fujita H; Department of Endocrinology, Diabetes, and Geriatric Medicine, Akita University Graduate School of Medicine, Akita, Japan.
Imai Y; Laboratory of Regulation for Intractable Infectious Diseases, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation Health and Nutrition, Osaka, Japan.
Drucker DJ; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Canada.
Seino Y; Kansai Electric Power Medical Research Institute, Osaka, Japan.
Yamada Y; Department of Endocrinology, Diabetes, and Geriatric Medicine, Akita University Graduate School of Medicine, Akita, Japan.; Kansai Electric Power Medical Research Institute, Osaka, Japan.
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Źródło :
Endocrinology [Endocrinology] 2020 Dec 01; Vol. 161 (12).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease.
Autorzy :
Baggio LL; Lunenfeld-Tanenbaum Research Institute, Department of Medicine, Mt. Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada.
Drucker DJ; Lunenfeld-Tanenbaum Research Institute, Department of Medicine, Mt. Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada. Electronic address: drucker@lunenfeld.ca.
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Źródło :
Molecular metabolism [Mol Metab] 2020 Sep 25, pp. 101090. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
The gut hormone receptor GIPR links energy availability to the control of hematopoiesis.
Autorzy :
Pujadas G; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, ON, M5G 1X5, Canada.
Varin EM; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, ON, M5G 1X5, Canada.
Baggio LL; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, ON, M5G 1X5, Canada.
Mulvihill EE; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, ON, M5G 1X5, Canada.
Bang KWA; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, ON, M5G 1X5, Canada.
Koehler JA; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, ON, M5G 1X5, Canada.
Matthews D; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, ON, M5G 1X5, Canada.
Drucker DJ; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, ON, M5G 1X5, Canada. Electronic address: drucker@lunenfeld.ca.
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Źródło :
Molecular metabolism [Mol Metab] 2020 Sep; Vol. 39, pp. 101008. Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Hematopoietic cell- versus enterocyte-derived dipeptidyl peptidase-4 differentially regulates triglyceride excursion in mice.
Autorzy :
Varin EM; Lunenfeld-Tanenbaum Research Institute, Department of Medicine, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Hanson AA; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Beaudry JL; Lunenfeld-Tanenbaum Research Institute, Department of Medicine, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Nguyen MA; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Cao X; Lunenfeld-Tanenbaum Research Institute, Department of Medicine, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Baggio LL; Lunenfeld-Tanenbaum Research Institute, Department of Medicine, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Mulvihill EE; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Drucker DJ; Lunenfeld-Tanenbaum Research Institute, Department of Medicine, Mt. Sinai Hospital, Toronto, Ontario, Canada.
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Źródło :
JCI insight [JCI Insight] 2020 Aug 20; Vol. 5 (16). Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans.
Autorzy :
Baggio LL; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.
Varin EM; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.
Koehler JA; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.
Cao X; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.
Lokhnygina Y; Duke Clinical Research Institute, Duke University, Durham, NC, USA.
Stevens SR; Duke Clinical Research Institute, Duke University, Durham, NC, USA.
Holman RR; Diabetes Trials Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Drucker DJ; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada. drucker@lunenfeld.ca.
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Źródło :
Nature communications [Nat Commun] 2020 Jul 28; Vol. 11 (1), pp. 3766. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiovascular Diseases/*immunology
Diabetes Mellitus, Type 2/*drug therapy
Dipeptidyl Peptidase 4/*blood
Dipeptidyl-Peptidase IV Inhibitors/*adverse effects
Inflammation/*immunology
Aged ; Animals ; Biomarkers/analysis ; Biomarkers/metabolism ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/immunology ; Diet, Atherogenic/adverse effects ; Diet, High-Fat/adverse effects ; Dipeptidyl Peptidase 4/immunology ; Dipeptidyl Peptidase 4/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/administration & dosage ; Disease Models, Animal ; Female ; Glucagon-Like Peptide-1 Receptor/genetics ; Humans ; Inflammation/blood ; Inflammation/diagnosis ; Inflammation/drug therapy ; Inflammation Mediators/analysis ; Inflammation Mediators/metabolism ; Male ; Metformin/administration & dosage ; Mice ; Mice, Knockout ; Middle Aged ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/blood ; Protein Isoforms/metabolism ; Sitagliptin Phosphate/administration & dosage ; Sitagliptin Phosphate/adverse effects
Czasopismo naukowe
Tytuł :
Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion.
Autorzy :
Panaro BL; Department of Medicine and the Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address: drucker@lunenfeld.ca.
Yusta B; Department of Medicine and the Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Matthews D; Department of Medicine and the Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Koehler JA; Department of Medicine and the Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Song Y; Department of Medicine and the Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Sandoval DA; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
Drucker DJ; Department of Medicine and the Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
Molecular metabolism [Mol Metab] 2020 Jul; Vol. 37, pp. 100990. Date of Electronic Publication: 2020 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Deciphering metabolic messages from the gut drives therapeutic innovation: the 2014 Banting Lecture.
Autorzy :
Drucker DJ; Department of Medicine, Mount Sinai Hospital and the Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada drucker@lunenfeld.ca.
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Źródło :
Diabetes [Diabetes] 2015 Feb; Vol. 64 (2), pp. 317-26.
Typ publikacji :
Biography; Historical Article; Lecture; Research Support, Non-U.S. Gov't
MeSH Terms :
Awards and Prizes*
Diabetes Mellitus/*history
Diabetes Mellitus/*metabolism
Gastrointestinal Tract/*metabolism
Hormones/*metabolism
Animals ; Canada ; Diabetes Mellitus/drug therapy ; Glucagon/metabolism ; Glucagon-Like Peptides/metabolism ; History, 21st Century ; Humans ; Insulin/metabolism ; Mice ; Societies, Medical/history ; United States
Personal Name as Subject :
Drucker DJ
Raport
Tytuł :
Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice.
Autorzy :
Fuchs S; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; The Hospital for Sick Children and.
Yusta B; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Baggio LL; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Varin EM; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Matthews D; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Drucker DJ; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
JCI insight [JCI Insight] 2020 Apr 23; Vol. 5 (8). Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling.
Autorzy :
Lund ML; Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sorrentino G; Laboratory of Metabolic Signaling, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Egerod KL; Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kroone C; Department of Thrombosis and Hemostasis, Leiden University Medical Centre, Leiden, the Netherlands.
Mortensen B; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Knop FK; Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Reimann F; Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, U.K.
Gribble FM; Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, U.K.
Drucker DJ; Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
de Koning EJP; Department of Medicine, Leiden University Medical Centre, Leiden, the Netherlands.; Hubrecht Institute/Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands.
Schoonjans K; Laboratory of Metabolic Signaling, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Bäckhed F; Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Molecular and Clinical Medicine at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Schwartz TW; Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Petersen N; Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark .
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Źródło :
Diabetes [Diabetes] 2020 Apr; Vol. 69 (4), pp. 614-623. Date of Electronic Publication: 2020 Feb 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bile Acids and Salts/*pharmacology
Cell Differentiation/*drug effects
Enteroendocrine Cells/*drug effects
Glucagon-Like Peptide 1/*metabolism
Paracrine Communication/*physiology
Receptors, G-Protein-Coupled/*metabolism
Serotonin/*metabolism
Animals ; Enteroendocrine Cells/physiology ; Female ; Glucagon-Like Peptide-1 Receptor/metabolism ; Humans ; Jejunum/drug effects ; Jejunum/metabolism ; Male ; Mice ; Paracrine Communication/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Advances in oral peptide therapeutics.
Autorzy :
Drucker DJ; Department of Medicine and Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. drucker@lunenfeld.ca.
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Źródło :
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2020 Apr; Vol. 19 (4), pp. 277-289. Date of Electronic Publication: 2019 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Peptides/*pharmacology
Peptides/*therapeutic use
Administration, Oral ; Animals ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Insulin/metabolism ; Proteins/pharmacology ; Proteins/therapeutic use
Czasopismo naukowe
Tytuł :
Glucagon-Like Peptide-1 Receptor Agonism Improves Nephrotoxic Serum Nephritis by Inhibiting T-Cell Proliferation.
Autorzy :
Moschovaki Filippidou F; Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Kirsch AH; Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Thelen M; Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Kétszeri M; Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Artinger K; Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Aringer I; Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Schabhüttl C; Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Mooslechner AA; Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Frauscher B; Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Pollheimer M; Institute of Pathology, Medical University of Graz, Graz, Austria.
Niedrist T; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Meinitzer A; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Drucker DJ; Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Pieber TR; Clinical Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Eller P; Intensive Care Unit, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Rosenkranz AR; Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Heinemann A; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria; BioTechMed, Graz, Austria.
Eller K; Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2020 Feb; Vol. 190 (2), pp. 400-411. Date of Electronic Publication: 2019 Nov 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon-Like Peptide-1 Receptor/*agonists
Hypoglycemic Agents/*pharmacology
Liraglutide/*pharmacology
Lymphocyte Activation/*immunology
Nephritis/*prevention & control
T-Lymphocytes/*immunology
Animals ; Glucagon-Like Peptide-1 Receptor/physiology ; Lymphocyte Activation/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nephritis/immunology ; Nephritis/metabolism ; Nephritis/pathology ; T-Lymphocytes/drug effects
Czasopismo naukowe
Tytuł :
Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension.
Autorzy :
Helmstädter J; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Frenis K; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Filippou K; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Grill A; Center for Thrombosis and Hemostasis (A.G., P.W., W.R., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany (A.G., W.R., T.M., A.D.).
Dib M; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Kalinovic S; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Pawelke F; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Kus K; Jagiellonian Centre for Experimental Therapeutics (JCET) (K.K., S.C.), Jagiellonian University, Krakow, Poland.
Kröller-Schön S; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Oelze M; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Chlopicki S; Jagiellonian Centre for Experimental Therapeutics (JCET) (K.K., S.C.), Jagiellonian University, Krakow, Poland.; Chair of Pharmacology (S.C.), Jagiellonian University, Krakow, Poland.
Schuppan D; Institute of Translational Immunology (D.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Wenzel P; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; Center for Thrombosis and Hemostasis (A.G., P.W., W.R., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Ruf W; Center for Thrombosis and Hemostasis (A.G., P.W., W.R., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany (A.G., W.R., T.M., A.D.).
Drucker DJ; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Canada (D.J.D.).
Münzel T; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany (A.G., W.R., T.M., A.D.).
Daiber A; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany (A.G., W.R., T.M., A.D.).
Steven S; From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; Center for Thrombosis and Hemostasis (A.G., P.W., W.R., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Jan; Vol. 40 (1), pp. 145-158. Date of Electronic Publication: 2019 Nov 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*genetics
Blood Pressure/*drug effects
Endothelial Cells/*metabolism
Glucagon-Like Peptide-1 Receptor/*genetics
Hypertension/*genetics
Liraglutide/*pharmacology
RNA/*genetics
Animals ; Atherosclerosis/etiology ; Atherosclerosis/prevention & control ; Blotting, Western ; Cells, Cultured ; Disease Models, Animal ; Endothelial Cells/pathology ; Glucagon-Like Peptide-1 Receptor/biosynthesis ; Hypertension/complications ; Hypertension/metabolism ; Hypoglycemic Agents/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Proglucagon-Derived Peptides, Glucose-Dependent Insulinotropic Polypeptide, and Dipeptidyl Peptidase-4-Mechanisms of Action in Adipose Tissue.
Autorzy :
Beaudry JL; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto ON, Canada.
Drucker DJ; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto ON, Canada.
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Źródło :
Endocrinology [Endocrinology] 2020 Jan 01; Vol. 161 (1).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Adipose Tissue/*metabolism
Dipeptidyl Peptidase 4/*metabolism
Gastric Inhibitory Polypeptide/*metabolism
Glucose/*metabolism
Proglucagon/*metabolism
Animals ; Humans ; Proglucagon/chemistry
Czasopismo naukowe
Tytuł :
Glucagon-like peptide 1 (GLP-1).
Autorzy :
Müller TD; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, Tübingen, Germany. Electronic address: .
Finan B; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.
Bloom SR; Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
D'Alessio D; Division of Endocrinology, Duke University Medical Center, Durham, NC, USA.
Drucker DJ; The Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Ontario, M5G1X5, Canada.
Flatt PR; SAAD Centre for Pharmacy & Diabetes, Ulster University, Coleraine, Northern Ireland, UK.
Fritsche A; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany; Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany.
Gribble F; Metabolic Research Laboratories and Medical Research Council Metabolic Diseases Unit, Wellcome Trust-Medical Research Council, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK.
Grill HJ; Institute of Diabetes, Obesity and Metabolism, Department of Psychology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Habener JF; Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Holst JJ; Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Langhans W; Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.
Meier JJ; Diabetes Division, St Josef Hospital, Ruhr-University Bochum, Bochum, Germany.
Nauck MA; Diabetes Center Bochum-Hattingen, St Josef Hospital (Ruhr-Universität Bochum), Bochum, Germany.
Perez-Tilve D; Department of Internal Medicine, University of Cincinnati-College of Medicine, Cincinnati, OH, USA.
Pocai A; Cardiovascular & ImmunoMetabolism, Janssen Research & Development, Welsh and McKean Roads, Spring House, PA, 19477, USA.
Reimann F; Metabolic Research Laboratories and Medical Research Council Metabolic Diseases Unit, Wellcome Trust-Medical Research Council, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK.
Sandoval DA; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Schwartz TW; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DL-2200, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark.
Seeley RJ; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Stemmer K; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Tang-Christensen M; Obesity Research, Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark.
Woods SC; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA.
DiMarchi RD; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA; Department of Chemistry, Indiana University, Bloomington, IN, USA.
Tschöp MH; German Center for Diabetes Research (DZD), Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich, Germany; Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
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Źródło :
Molecular metabolism [Mol Metab] 2019 Dec; Vol. 30, pp. 72-130. Date of Electronic Publication: 2019 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Glucagon-Like Peptide 1/*metabolism
Glucagon-Like Peptide 1/*pharmacology
Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Gastric Inhibitory Polypeptide/metabolism ; Glucagon-Like Peptide-1 Receptor/metabolism ; Glucose/metabolism ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/metabolism ; Insulin Secretion ; Insulin-Secreting Cells/metabolism ; Obesity/metabolism ; Receptors, Glucagon/metabolism
Czasopismo naukowe
Tytuł :
Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice.
Autorzy :
Song Y; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, ON M5G1X5, Canada; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
Koehler JA; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, ON M5G1X5, Canada.
Baggio LL; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, ON M5G1X5, Canada.
Powers AC; Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN 37232-0475, USA; Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA.
Sandoval DA; Department of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
Drucker DJ; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, ON M5G1X5, Canada. Electronic address: drucker@lunenfeld.ca.
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Źródło :
Cell metabolism [Cell Metab] 2019 Nov 05; Vol. 30 (5), pp. 976-986.e3. Date of Electronic Publication: 2019 Sep 05.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Gastrointestinal Microbiome*
Animals ; Glucose ; Homeostasis ; Humans ; Insulin ; Mice ; Peptides ; Proglucagon
Czasopismo naukowe
Tytuł :
Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine.
Autorzy :
Deshmukh AS; Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Peijs L; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark.
Beaudry JL; The Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Department of Medicine, University of Toronto, Toronto, ON M5G 1X5, Canada.
Jespersen NZ; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark.
Nielsen CH; Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Department of Biomedical Sciences, Rigshospitalet and University of Copenhagen, Copenhagen 2200, Denmark; Minerva Imaging ApS, Copenhagen 2200, Denmark.
Ma T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Brunner AD; Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Larsen TJ; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark.
Bayarri-Olmos R; Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen 2100, Denmark.
Prabhakar BS; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Helgstrand C; Global Drug Discovery, Novo Nordisk A/S, Måløv 2760, Denmark.
Severinsen MCK; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark.
Holst B; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Kjaer A; Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Department of Biomedical Sciences, Rigshospitalet and University of Copenhagen, Copenhagen 2200, Denmark.
Tang-Christensen M; Global Drug Discovery, Novo Nordisk A/S, Måløv 2760, Denmark.
Sanfridson A; Global Drug Discovery, Novo Nordisk A/S, Måløv 2760, Denmark.
Garred P; Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen 2100, Denmark.
Privé GG; Princess Margaret Cancer Centre, Toronto, ON M5G 1L7, Canada.
Pedersen BK; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark.
Gerhart-Hines Z; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Nielsen S; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark.
Drucker DJ; The Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Department of Medicine, University of Toronto, Toronto, ON M5G 1X5, Canada.
Mann M; Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address: .
Scheele C; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. Electronic address: .
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Źródło :
Cell metabolism [Cell Metab] 2019 Nov 05; Vol. 30 (5), pp. 963-975.e7. Date of Electronic Publication: 2019 Oct 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipocytes, Brown/*metabolism
Adipocytes, White/*metabolism
Adipose Tissue, Brown/*metabolism
Neoplasm Proteins/*blood
Proteomics/*methods
Adult ; Aged ; Animals ; Cohort Studies ; Female ; Gene Knockdown Techniques ; Goiter/blood ; Goiter/pathology ; Goiter/surgery ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Neoplasm Proteins/genetics ; Secretory Pathway/genetics ; Signal Transduction/genetics ; Transfection ; Young Adult
Czasopismo naukowe
Tytuł :
Physiological roles of the GIP receptor in murine brown adipose tissue.
Autorzy :
Beaudry JL; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Kaur KD; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Varin EM; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Baggio LL; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Cao X; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Mulvihill EE; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Bates HE; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Campbell JE; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.
Drucker DJ; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address: drucker@lunenfeld.ca.
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Źródło :
Molecular metabolism [Mol Metab] 2019 Oct; Vol. 28, pp. 14-25. Date of Electronic Publication: 2019 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipose Tissue, Brown/*metabolism
Receptors, Gastrointestinal Hormone/*metabolism
Animals ; Cell Line ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Treatment of type 2 diabetes with the designer cytokine IC7Fc.
Autorzy :
Findeisen M; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Allen TL; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.
Henstridge DC; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.
Kammoun H; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.
Brandon AE; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Baggio LL; Department of Medicine, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Watt KI; Centre of Muscle Research, Department of Physiology, The University of Melbourne, Melbourne, Victoria, Australia.
Pal M; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.
Cron L; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Estevez E; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Yang C; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.
Kowalski GM; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.; Institute for Physical Activity and Nutrition, Deakin University, Melbourne, Victoria, Australia.
O'Reilly L; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Egan C; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
Sun E; Molecular & Cellular Physiology Laboratory, Flinders University, Adelaide, South Australia, Australia.
Thai LM; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Krippner G; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.
Adams TE; CSIRO Manufacturing, Melbourne, Victoria, Australia.
Lee RS; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.
Grötzinger J; Department of Biochemistry, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Garbers C; Institut Für Pathologie, Otto von Guericke University, Magdeburg, Germany.
Risis S; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.
Kraakman MJ; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.
Mellet NA; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.
Sligar J; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Kimber ET; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Young RL; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Cowley MA; Department of Physiology, Monash University, Melbourne, Victoria, Australia.
Bruce CR; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.; Institute for Physical Activity and Nutrition, Deakin University, Melbourne, Victoria, Australia.
Meikle PJ; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia.
Baldock PA; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Gregorevic P; Centre of Muscle Research, Department of Physiology, The University of Melbourne, Melbourne, Victoria, Australia.
Biden TJ; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Cooney GJ; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Keating DJ; Molecular & Cellular Physiology Laboratory, Flinders University, Adelaide, South Australia, Australia.
Drucker DJ; Department of Medicine, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Rose-John S; Department of Biochemistry, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Febbraio MA; The Garvan Institute of Medical Research, Sydney, New South Wales, Australia. .; Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia. .; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia. .
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Źródło :
Nature [Nature] 2019 Oct; Vol. 574 (7776), pp. 63-68. Date of Electronic Publication: 2019 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytokine Receptor gp130/*metabolism
Cytokines/*chemical synthesis
Cytokines/*therapeutic use
Diabetes Mellitus, Type 2/*drug therapy
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Binding, Competitive ; Cytokines/chemistry ; Diabetes Mellitus, Type 2/metabolism ; Drug Design ; Fatty Liver/prevention & control ; Glucose Tolerance Test ; Humans ; Hyperglycemia/drug therapy ; Hyperglycemia/metabolism ; Incretins/metabolism ; Interleukin-6/antagonists & inhibitors ; Interleukin-6/metabolism ; Male ; Mice ; Muscle, Skeletal/drug effects ; Obesity/metabolism ; Pancreas/metabolism ; Phosphoproteins/metabolism ; Protein Engineering ; Receptors, Interleukin-6/metabolism ; Signal Transduction ; Transcription Factors ; Weight Gain/drug effects
Czasopismo naukowe

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