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Tytuł :
Insulin Secretion Depends on Intra-islet Glucagon Signaling.
Autorzy :
Svendsen B; NovoNordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: .
Larsen O; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Gabe MBN; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Christiansen CB; NovoNordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Rosenkilde MM; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Drucker DJ; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, and Department of Medicine, University of Toronto, Toronto, ON M5G 1X5, Canada.
Holst JJ; NovoNordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
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Źródło :
Cell reports [Cell Rep] 2018 Oct 30; Vol. 25 (5), pp. 1127-1134.e2.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Secretion*
Signal Transduction*
Glucagon/*metabolism
Islets of Langerhans/*metabolism
Animals ; COS Cells ; Chlorocebus aethiops ; Cyclic AMP/metabolism ; Exenatide/pharmacology ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide-1 Receptor/antagonists & inhibitors ; Glucagon-Like Peptide-1 Receptor/metabolism ; Mice, Inbred C57BL ; Perfusion
Czasopismo naukowe
Tytuł :
Islet α cells and glucagon--critical regulators of energy homeostasis.
Autorzy :
Campbell JE; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, TCP5-1004, Toronto, ON M5G 1X5, Canada.
Drucker DJ; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, TCP5-1004, Toronto, ON M5G 1X5, Canada.
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Źródło :
Nature reviews. Endocrinology [Nat Rev Endocrinol] 2015 Jun; Vol. 11 (6), pp. 329-38. Date of Electronic Publication: 2015 Apr 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Homeostasis*
Blood Glucose/*metabolism
Diabetes Mellitus, Type 1/*metabolism
Diabetes Mellitus, Type 2/*metabolism
Energy Metabolism/*physiology
Glucagon/*metabolism
Glucagon-Secreting Cells/*metabolism
Adipose Tissue/metabolism ; Brain/metabolism ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon/physiology ; Glucagon/therapeutic use ; Glucagon-Secreting Cells/physiology ; Hormones/therapeutic use ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Liver/metabolism ; Myocardium/metabolism
Czasopismo naukowe
Tytuł :
Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.
Autorzy :
Ali S; Department of Laboratory Medicine and Pathobiology, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Lamont BJ
Charron MJ
Drucker DJ
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2011 May; Vol. 121 (5), pp. 1917-29. Date of Electronic Publication: 2011 Apr 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon/*metabolism
Incretins/*metabolism
Receptors, Glucagon/*genetics
Animals ; Cholecystokinin/metabolism ; Glucagon-Like Peptide-1 Receptor ; Glucose Tolerance Test ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Oxygen Consumption ; Pancreas/metabolism ; Phenotype ; Rats
Czasopismo naukowe
Tytuł :
Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes.
Autorzy :
Ali S; Mt. Sinai Hospital, Toronto, ON, Canada M5T 3L9.
Drucker DJ
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2009 Mar; Vol. 296 (3), pp. E415-21. Date of Electronic Publication: 2008 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Diabetes Mellitus, Type 2/*metabolism
Diabetes Mellitus, Type 2/*therapy
Glucagon/*metabolism
Receptors, Glucagon/*metabolism
Animals ; Humans ; Hyperglycemia/metabolism ; Hyperglycemia/therapy ; Receptors, Glucagon/genetics
Czasopismo naukowe
Tytuł :
The glucagon receptor is required for the adaptive metabolic response to fasting.
Autorzy :
Longuet C; Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5G 1X5, Canada.
Sinclair EM
Maida A
Baggio LL
Maziarz M
Charron MJ
Drucker DJ
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Źródło :
Cell metabolism [Cell Metab] 2008 Nov; Vol. 8 (5), pp. 359-71.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Fasting/*physiology
Glucagon/*physiology
Hepatocytes/*metabolism
Receptors, Glucagon/*physiology
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Adaptation, Biological ; Animals ; Cells, Cultured ; Fatty Acids/metabolism ; Female ; Glucagon/pharmacology ; Hepatocytes/drug effects ; Lipid Metabolism ; Male ; Mice ; Mice, Knockout ; Oxidation-Reduction ; PPAR alpha/genetics ; PPAR alpha/metabolism ; RNA, Messenger/biosynthesis ; Receptors, Glucagon/genetics ; Triglycerides/blood ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
The evidence for achieving glycemic control with incretin mimetics.
Autorzy :
Drucker DJ; Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
The Diabetes educator [Diabetes Educ] 2006 Mar-Apr; Vol. 32 Suppl 2, pp. 72S-81S.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Blood Glucose/*metabolism
Diabetes Mellitus, Type 2/*drug therapy
Glucagon/*physiology
Glucagon-Like Peptide 1/*physiology
Hypoglycemic Agents/*therapeutic use
Diabetes Mellitus, Type 2/blood ; Humans ; Insulin/therapeutic use
Czasopismo naukowe
Tytuł :
Glucagon and glucagon-like peptide receptors as drug targets.
Autorzy :
Estall JL; Department of Laboratory Medicine and Pathobiology, and Medicine, University of Toronto, The Banting and Best Diabetes Centre, Toronto General Hospital, Canada.
Drucker DJ
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Źródło :
Current pharmaceutical design [Curr Pharm Des] 2006; Vol. 12 (14), pp. 1731-50.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Glucagon/*metabolism
Receptors, Glucagon/*metabolism
Amino Acid Sequence ; Animals ; Diabetes Mellitus/drug therapy ; Glucagon-Like Peptide-1 Receptor ; Glucagon-Like Peptides/pharmacology ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Molecular Sequence Data ; Oxyntomodulin
Czasopismo naukowe
Tytuł :
Proglucagon-derived peptides: mechanisms of action and therapeutic potential.
Autorzy :
Sinclair EM; Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital and the University of Toronto, Toronto, Ontario, Canada.
Drucker DJ
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Źródło :
Physiology (Bethesda, Md.) [Physiology (Bethesda)] 2005 Oct; Vol. 20, pp. 357-65.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Protein Precursors*/physiology
Protein Precursors*/therapeutic use
Glucagon/*analogs & derivatives
Peptides/*physiology
Peptides/*therapeutic use
Animals ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl Peptidase 4/drug effects ; Disease ; Glucagon/physiology ; Glucagon/therapeutic use ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide 2 ; Glucagon-Like Peptide-1 Receptor ; Glucagon-Like Peptides/physiology ; Humans ; Intestinal Diseases/drug therapy ; Peptide Fragments/physiology ; Peptide Fragments/therapeutic use ; Peptides/metabolism ; Proglucagon ; Protease Inhibitors/therapeutic use ; Receptors, Glucagon/agonists ; Receptors, Glucagon/physiology
Czasopismo naukowe
Tytuł :
GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.
Autorzy :
Hansotia T; Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, and the University of Toronto, 200 Elizabeth Street MBRW4R-402, Toronto, Ontario, Canada M5G 2C4.
Drucker DJ
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Źródło :
Regulatory peptides [Regul Pept] 2005 Jun 15; Vol. 128 (2), pp. 125-34.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Gastric Inhibitory Polypeptide/*physiology
Gastrointestinal Hormones/*physiology
Glucagon/*physiology
Peptide Fragments/*physiology
Protein Precursors/*physiology
Receptors, Gastrointestinal Hormone/*genetics
Receptors, Glucagon/*genetics
Animals ; Diabetes Mellitus, Type 2/drug therapy ; Gastric Inhibitory Polypeptide/genetics ; Gastrointestinal Hormones/genetics ; Glucagon/genetics ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide-1 Receptor ; Glucose/metabolism ; Humans ; Mice ; Mice, Knockout ; Pancreas/drug effects ; Peptide Fragments/genetics ; Protein Precursors/genetics
Czasopismo naukowe
Tytuł :
Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line.
Autorzy :
Reimann F; Cambridge Institute for Medical Research, University of Cambridge, Department of Clinical Biochemistry, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK. />Maziarz M
Flock G
Habib AM
Drucker DJ
Gribble FM
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Źródło :
The Journal of physiology [J Physiol] 2005 Feb 15; Vol. 563 (Pt 1), pp. 161-75. Date of Electronic Publication: 2004 Dec 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Enteroendocrine Cells/*physiology
Glucagon/*metabolism
Ion Channels/*physiology
Membrane Potentials/*physiology
Peptide Fragments/*metabolism
Potassium/*metabolism
Protein Precursors/*metabolism
Sodium/*metabolism
Animals ; Cations, Monovalent ; Cell Line ; Electric Conductivity ; Glucagon-Like Peptide 1 ; Ion Channel Gating/physiology ; Ion Channels/analysis ; Ion Channels/chemistry ; Mice
Czasopismo naukowe
Tytuł :
beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.
Autorzy :
Li Y; Department of Medicine, University of Toronto, Banting and Best Diabetes Centre, Toronto General Hospital, 200 Elizabeth St., MBRW 4R402-2, Toronto, Canada M5G 2C4.
Cao X
Li LX
Brubaker PL
Edlund H
Drucker DJ
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Źródło :
Diabetes [Diabetes] 2005 Feb; Vol. 54 (2), pp. 482-91.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon/*physiology
Homeodomain Proteins/*genetics
Islets of Langerhans/*physiology
Peptide Fragments/*physiology
Protein Precursors/*physiology
Receptors, Glucagon/*physiology
Trans-Activators/*genetics
Animals ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Cell Division/drug effects ; Cell Survival/drug effects ; Exenatide ; Female ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide-1 Receptor ; Glucose Tolerance Test ; Homeostasis ; Islets of Langerhans/cytology ; Islets of Langerhans/drug effects ; Mice ; Mice, Knockout ; Mice, Mutant Strains ; Peptides/pharmacology ; Trans-Activators/deficiency ; Venoms/pharmacology
Czasopismo naukowe
Tytuł :
Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells.
Autorzy :
Flock G; Department of Medicine, Toronto General Hospital, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada.
Cao X
Drucker DJ
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Źródło :
Endocrinology [Endocrinology] 2005 Jan; Vol. 146 (1), pp. 441-9. Date of Electronic Publication: 2004 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endocrine Glands/*metabolism
Glucagon/*antagonists & inhibitors
Glucagon/*genetics
Homeodomain Proteins/*physiology
Intestinal Mucosa/*metabolism
Islets of Langerhans/*metabolism
Protein Precursors/*antagonists & inhibitors
Protein Precursors/*genetics
Trans-Activators/*physiology
Transcription, Genetic/*physiology
Animals ; Cell Line ; Endocrine Glands/cytology ; Glucagon/metabolism ; Glucagon-Like Peptide 1 ; Homeodomain Proteins/metabolism ; Intestines/cytology ; Islets of Langerhans/cytology ; Mice ; Peptide Fragments/metabolism ; Proglucagon ; Protein Precursors/metabolism ; Trans-Activators/metabolism ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice.
Autorzy :
Lachey JL; Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237-0559, USA.
D'Alessio DA
Rinaman L
Elmquist JK
Drucker DJ
Seeley RJ
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Źródło :
Endocrinology [Endocrinology] 2005 Jan; Vol. 146 (1), pp. 458-62. Date of Electronic Publication: 2004 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Avoidance Learning*
Mice*
Anorexia/*chemically induced
Brain Diseases/*chemically induced
Glucagon/*metabolism
Lithium Chloride/*poisoning
Peptide Fragments/*metabolism
Protein Precursors/*metabolism
Taste/*drug effects
Animals ; Anorexia/metabolism ; Glucagon/antagonists & inhibitors ; Glucagon/pharmacology ; Glucagon-Like Peptide 1 ; Male ; Mice, Inbred Strains ; Mice, Knockout ; Neurons/drug effects ; Neurons/metabolism ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/pharmacology ; Proglucagon ; Protein Precursors/antagonists & inhibitors ; Protein Precursors/pharmacology ; Rats ; Species Specificity
Czasopismo naukowe
Tytuł :
Clinical endocrinology and metabolism. Glucagon-like peptide-1 and glucagon-like peptide-2.
Autorzy :
Baggio LL; Department of Medicine, The Banting and Best Diabetes Centre, University of Toronto, Toronto General Hospital, 200 Elizabeth Street, MBRW 4R-402, Toronto, Ontario, Canada M5G 2C4.
Drucker DJ
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Źródło :
Best practice & research. Clinical endocrinology & metabolism [Best Pract Res Clin Endocrinol Metab] 2004 Dec; Vol. 18 (4), pp. 531-54.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Glucagon/*physiology
Peptide Fragments/*physiology
Peptides/*physiology
Protein Precursors/*physiology
Animals ; Cardiovascular Physiological Phenomena ; Diabetes Mellitus, Type 2/physiopathology ; Diabetes Mellitus, Type 2/therapy ; Feeding Behavior/physiology ; Glucagon/antagonists & inhibitors ; Glucagon/biosynthesis ; Glucagon/metabolism ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide 2 ; Glucose/metabolism ; Humans ; Nervous System Physiological Phenomena ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/biosynthesis ; Peptide Fragments/metabolism ; Peptides/metabolism ; Protein Precursors/antagonists & inhibitors ; Protein Precursors/biosynthesis ; Protein Precursors/metabolism
Czasopismo naukowe
Tytuł :
Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo.
Autorzy :
Baggio LL; Banting and Best Diabetes Centre, University of Toronto, Toronto General Hospital, 200 Elizabeth St., MBRW 4R-402, Toronto, Ontario Canada M5G 2C4. d.drucker@utoronto.ca.
Kim JG
Drucker DJ
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Źródło :
Diabetes [Diabetes] 2004 Dec; Vol. 53 Suppl 3, pp. S205-14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon/*pharmacology
Glucose/*metabolism
Islets of Langerhans/*physiology
Peptide Fragments/*pharmacology
Protein Precursors/*pharmacology
Receptors, Glucagon/*agonists
Receptors, Glucagon/*physiology
Animals ; Cyclic AMP/metabolism ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide-1 Receptor ; Islets of Langerhans/drug effects ; Kinetics ; Mice
Czasopismo naukowe
Tytuł :
A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis.
Autorzy :
Baggio LL; Toronto General Hospital, Banting and Best Diabetes Centre, 200 Elizabeth St., MBRW4R-402, Toronto, Canada.
Huang Q
Brown TJ
Drucker DJ
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Źródło :
Diabetes [Diabetes] 2004 Sep; Vol. 53 (9), pp. 2492-500.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon/*pharmacology
Peptide Fragments/*pharmacology
Protein Precursors/*pharmacology
Receptors, Glucagon/*metabolism
Recombinant Proteins/*pharmacology
Satiety Response/*drug effects
Satiety Response/*physiology
Albumins/genetics ; Albumins/pharmacology ; Animals ; Cells, Cultured ; Cricetinae ; Eating/drug effects ; Eating/physiology ; Gastric Emptying/drug effects ; Gastric Emptying/physiology ; Gastrointestinal Motility/drug effects ; Gastrointestinal Motility/physiology ; Glucagon/genetics ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide-1 Receptor ; Glucose/metabolism ; Homeostasis/drug effects ; Homeostasis/physiology ; Humans ; Kidney/cytology ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Peptide Fragments/genetics ; Protein Precursors/genetics ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Receptors, Glucagon/genetics
Czasopismo naukowe
Tytuł :
Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.
Autorzy :
Baggio LL; Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Ontario, Canada.
Huang Q
Brown TJ
Drucker DJ
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Źródło :
Gastroenterology [Gastroenterology] 2004 Aug; Vol. 127 (2), pp. 546-58.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eating/*drug effects
Energy Metabolism/*drug effects
Glucagon/*pharmacology
Glucagon-Like Peptides/*pharmacology
Peptide Fragments/*pharmacology
Protein Precursors/*pharmacology
Receptors, Glucagon/*metabolism
Amino Acid Sequence ; Animals ; Binding, Competitive ; Brain/metabolism ; Cells, Cultured ; Cricetinae ; Dose-Response Relationship, Drug ; Exenatide ; Glucagon/genetics ; Glucagon/metabolism ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide 2 ; Glucagon-Like Peptide-1 Receptor ; Glucagon-Like Peptides/metabolism ; Injections, Intraperitoneal ; Injections, Intraventricular ; Iodine Radioisotopes ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Sequence Data ; Oxyntomodulin ; Peptide Fragments/metabolism ; Peptides/metabolism ; Peptides/pharmacology ; Proglucagon ; Protein Precursors/genetics ; Protein Precursors/metabolism ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Glucagon/agonists ; Receptors, Glucagon/genetics ; Venoms/metabolism ; Venoms/pharmacology
Czasopismo naukowe
Tytuł :
Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system.
Autorzy :
Brubaker PL; Room 3366, Medical Science Building, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8. />Drucker DJ
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Źródło :
Endocrinology [Endocrinology] 2004 Jun; Vol. 145 (6), pp. 2653-9. Date of Electronic Publication: 2004 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Apoptosis/*physiology
Central Nervous System/*physiology
Glucagon/*physiology
Intestines/*cytology
Pancreas/*cytology
Peptide Fragments/*physiology
Peptides/*physiology
Protein Precursors/*physiology
Animals ; Cell Division/physiology ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide 2 ; Intestines/physiology ; Pancreas/physiology
Czasopismo naukowe
Tytuł :
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors.
Autorzy :
Preitner F; Institute of Pharmacology and Toxicology, Lausanne, Switzerland.
Ibberson M
Franklin I
Binnert C
Pende M
Gjinovci A
Hansotia T
Drucker DJ
Wollheim C
Burcelin R
Thorens B
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2004 Feb; Vol. 113 (4), pp. 635-45.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gastric Inhibitory Polypeptide/*metabolism
Glucagon/*metabolism
Insulin/*metabolism
Peptide Fragments/*metabolism
Protein Precursors/*metabolism
Receptors, Gastrointestinal Hormone/*metabolism
Receptors, Glucagon/*metabolism
Animals ; Blood Glucose/metabolism ; Carbachol/metabolism ; Cyclic AMP/metabolism ; Female ; Glucagon-Like Peptide 1 ; Glucose Tolerance Test ; Insulin Secretion ; Male ; Mice ; Mice, Knockout ; Pancreas/metabolism ; Receptors, Gastrointestinal Hormone/genetics ; Receptors, Glucagon/genetics
Czasopismo naukowe
Tytuł :
Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis.
Autorzy :
Drucker DJ; Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada M5G 2C4. d.drucker@utoronto.ca.
Pokaż więcej
Źródło :
Endocrinology [Endocrinology] 2003 Dec; Vol. 144 (12), pp. 5145-8.
Typ publikacji :
Comment; Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Apoptosis/*physiology
Glucagon/*physiology
Islets of Langerhans/*cytology
Peptide Fragments/*physiology
Protein Precursors/*physiology
Animals ; Cell Division/physiology ; Glucagon-Like Peptide 1 ; Humans ; Islets of Langerhans/physiology
Czasopismo naukowe

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