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    Wyświetlanie 1-34 z 34
    Tytuł:
    Sitagliptin Accelerates Endothelial Regeneration after Vascular Injury Independent from GLP1 Receptor Signaling.
    Autorzy:
    Remm F; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
    Kränkel N; Department of Cardiology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
    Lener D; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
    Drucker DJ; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada.
    Sopper S; Department of Internal Medicine V, Hematology & Oncology, Medical University of Innsbruck, Innsbruck, Austria.
    Brenner C; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.; Department of Cardiology, Reha Zentrum Muenster, Münster, Tirol, Austria.
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    Źródło:
    Stem cells international [Stem Cells Int] 2018 Feb 08; Vol. 2018, pp. 5284963. Date of Electronic Publication: 2018 Feb 08 (Print Publication: 2018).
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
    Autorzy:
    Finan B; 1] Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [2] Department of Medicine, Division of Metabolic Diseases,Technische Universität München, Munich, Germany. [3] Department of Chemistry, Indiana University, Bloomington, Indiana, USA.
    Yang B; 1] Department of Chemistry, Indiana University, Bloomington, Indiana, USA. [2] Marcadia Biotech, Carmel, Indiana, USA.
    Ottaway N; Metabolic Diseases Institute, Division of Endocrinology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
    Smiley DL; Department of Chemistry, Indiana University, Bloomington, Indiana, USA.
    Ma T; 1] Department of Chemistry, Indiana University, Bloomington, Indiana, USA. [2] Research Center, Beijing Hanmi Pharm., Beijing, China.
    Clemmensen C; 1] Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [2] Department of Medicine, Division of Metabolic Diseases,Technische Universität München, Munich, Germany.
    Chabenne J; 1] Department of Chemistry, Indiana University, Bloomington, Indiana, USA. [2] AIT Laboratories, Indianapolis, Indiana, USA.
    Zhang L; Marcadia Biotech, Carmel, Indiana, USA.
    Habegger KM; Comprehensive Diabetes Center, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama, USA.
    Fischer K; 1] Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [2] Department of Medicine, Division of Metabolic Diseases,Technische Universität München, Munich, Germany.
    Campbell JE; Department of Medicine, Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
    Sandoval D; Metabolic Diseases Institute, Division of Endocrinology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
    Seeley RJ; Metabolic Diseases Institute, Division of Endocrinology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
    Bleicher K; Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
    Uhles S; Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
    Riboulet W; Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
    Funk J; Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
    Hertel C; Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
    Belli S; Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
    Sebokova E; Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
    Conde-Knape K; Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
    Konkar A; Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
    Drucker DJ; Department of Medicine, Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
    Gelfanov V; Department of Chemistry, Indiana University, Bloomington, Indiana, USA.
    Pfluger PT; 1] Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [2] Department of Medicine, Division of Metabolic Diseases,Technische Universität München, Munich, Germany.
    Müller TD; 1] Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [2] Department of Medicine, Division of Metabolic Diseases,Technische Universität München, Munich, Germany.
    Perez-Tilve D; Metabolic Diseases Institute, Division of Endocrinology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
    DiMarchi RD; Department of Chemistry, Indiana University, Bloomington, Indiana, USA.
    Tschöp MH; 1] Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [2] Department of Medicine, Division of Metabolic Diseases,Technische Universität München, Munich, Germany.
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    Źródło:
    Nature medicine [Nat Med] 2015 Jan; Vol. 21 (1), pp. 27-36. Date of Electronic Publication: 2014 Dec 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Diabetes Complications/*metabolism
    Diabetes Mellitus, Type 2/*metabolism
    Obesity/*metabolism
    Peptides/*administration & dosage
    Animals ; Blood Glucose/drug effects ; Body Weight/genetics ; Diabetes Complications/drug therapy ; Diabetes Complications/genetics ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/genetics ; Glucagon-Like Peptide 1/agonists ; Glucagon-Like Peptide 1/metabolism ; HEK293 Cells ; Humans ; Insulin/biosynthesis ; Insulin/metabolism ; Mice ; Obesity/drug therapy ; Obesity/genetics ; Peptides/chemical synthesis ; Peptides/metabolism ; Rats ; Receptors, Gastrointestinal Hormone/agonists ; Receptors, Gastrointestinal Hormone/metabolism ; Receptors, Glucagon/agonists ; Receptors, Glucagon/metabolism ; Rodentia
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy.
    Autorzy:
    Moffett RC; SAAD centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine, Northern Ireland.
    Vasu S; SAAD centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine, Northern Ireland.
    Thorens B; Centre for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
    Drucker DJ; The Lunenfield - Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
    Flatt PR; SAAD centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine, Northern Ireland.
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    Źródło:
    PloS one [PLoS One] 2014 Jun 13; Vol. 9 (6), pp. e96863. Date of Electronic Publication: 2014 Jun 13 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Glucagon-Like Peptide 1/*blood
    Insulin/*metabolism
    Islets of Langerhans/*cytology
    Pregnancy/*metabolism
    Receptors, Gastrointestinal Hormone/*genetics
    Receptors, Glucagon/*genetics
    Adaptation, Physiological ; Animals ; Cell Size ; Female ; Gastric Inhibitory Polypeptide/blood ; Gene Knockout Techniques ; Glucagon-Like Peptide-1 Receptor ; Islets of Langerhans/metabolism ; Mice ; Mice, Inbred C57BL ; Receptors, Gastrointestinal Hormone/metabolism ; Receptors, Glucagon/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Metabolic disease puts up a fight: are diet and exercise helpful for the heart?
    Autorzy:
    Lovshin JA; Department of Medicine, Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
    Drucker DJ
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    Źródło:
    Nature medicine [Nat Med] 2013 Oct; Vol. 19 (10), pp. 1216-7.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Diet*
    Exercise*
    Diabetes Mellitus, Type 2/*physiopathology
    Heart/*physiopathology
    Diabetes Mellitus, Type 2/diet therapy ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/therapeutic use ; Weight Loss
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure.
    Autorzy:
    Kim M; Department of Medicine, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
    Platt MJ
    Shibasaki T
    Quaggin SE
    Backx PH
    Seino S
    Simpson JA
    Drucker DJ
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    Źródło:
    Nature medicine [Nat Med] 2013 May; Vol. 19 (5), pp. 567-75. Date of Electronic Publication: 2013 Mar 31.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Blood Pressure*
    Gene Expression Regulation*
    Atrial Natriuretic Factor/*metabolism
    Guanine Nucleotide Exchange Factors/*metabolism
    Receptors, Glucagon/*metabolism
    Animals ; Aorta/metabolism ; Aorta/pathology ; Cyclic GMP/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Endothelium, Vascular/metabolism ; Glucagon-Like Peptide 1/analogs & derivatives ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide-1 Receptor ; Liraglutide ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Natriuretic Peptide, C-Type/genetics ; Perfusion ; Protein Precursors/genetics ; Vasodilation
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.
    Autorzy:
    Ellingsgaard H; Clinic for Endocrinology, Diabetes & Metabolism and Department Biomedicine, University Hospital Basel, Basel, Switzerland. />Hauselmann I
    Schuler B
    Habib AM
    Baggio LL
    Meier DT
    Eppler E
    Bouzakri K
    Wueest S
    Muller YD
    Hansen AM
    Reinecke M
    Konrad D
    Gassmann M
    Reimann F
    Halban PA
    Gromada J
    Drucker DJ
    Gribble FM
    Ehses JA
    Donath MY
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    Źródło:
    Nature medicine [Nat Med] 2011 Oct 30; Vol. 17 (11), pp. 1481-9. Date of Electronic Publication: 2011 Oct 30.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Enteroendocrine Cells/*metabolism
    Glucagon-Like Peptide 1/*metabolism
    Glucagon-Secreting Cells/*metabolism
    Insulin/*metabolism
    Interleukin-6/*metabolism
    Animals ; Blood Glucose/metabolism ; Cells, Cultured ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Diet, High-Fat ; Disease Models, Animal ; Enteroendocrine Cells/drug effects ; Female ; Glucagon-Secreting Cells/drug effects ; Glucose Tolerance Test ; Humans ; Insulin Secretion ; Interleukin-6/antagonists & inhibitors ; Interleukin-6/genetics ; Interleukin-6/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Physical Conditioning, Animal ; Signal Transduction/drug effects ; Signal Transduction/physiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control.
    Autorzy:
    Dao TM; Institut National de la Santé et de la Recherche Médicale U1048, Institut de recherche sur les Maladies Métaboliques et Cardiovasculaire, I2MC, Toulouse, France.
    Waget A
    Klopp P
    Serino M
    Vachoux C
    Pechere L
    Drucker DJ
    Champion S
    Barthélemy S
    Barra Y
    Burcelin R
    Sérée E
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    Źródło:
    PloS one [PLoS One] 2011; Vol. 6 (6), pp. e20700. Date of Electronic Publication: 2011 Jun 06.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Blood Glucose/*metabolism
    Glucagon-Like Peptide 1/*metabolism
    Stilbenes/*pharmacology
    Animals ; Dietary Fats/adverse effects ; Dipeptidyl Peptidase 4/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Glucagon-Like Peptide-1 Receptor ; Glucose Intolerance/chemically induced ; Glucose Intolerance/drug therapy ; Glucose Intolerance/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Intestines/drug effects ; Intestines/microbiology ; Male ; Metagenome/drug effects ; Mice ; Mice, Inbred C57BL ; Receptors, Glucagon/metabolism ; Resveratrol ; Stilbenes/therapeutic use ; Time Factors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Liraglutide.
    Autorzy:
    Drucker DJ; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada. d.drucker@utoronto.ca
    Dritselis A
    Kirkpatrick P
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    Źródło:
    Nature reviews. Drug discovery [Nat Rev Drug Discov] 2010 Apr; Vol. 9 (4), pp. 267-8.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Diabetes Mellitus, Type 2/*drug therapy
    Glucagon-Like Peptide 1/*analogs & derivatives
    Hypoglycemic Agents/*therapeutic use
    Adult ; Drug Approval ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide 1/therapeutic use ; Humans ; Hypoglycemic Agents/pharmacology ; Liraglutide ; Randomized Controlled Trials as Topic ; United States ; United States Food and Drug Administration
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Normalization of obesity-associated insulin resistance through immunotherapy.
    Autorzy:
    Winer S; Department of Pediatrics & Immunology, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
    Chan Y
    Paltser G
    Truong D
    Tsui H
    Bahrami J
    Dorfman R
    Wang Y
    Zielenski J
    Mastronardi F
    Maezawa Y
    Drucker DJ
    Engleman E
    Winer D
    Dosch HM
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    Źródło:
    Nature medicine [Nat Med] 2009 Aug; Vol. 15 (8), pp. 921-9. Date of Electronic Publication: 2009 Jul 26.
    Typ publikacji:
    Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Insulin Resistance/*immunology
    Obesity/*complications
    Obesity/*therapy
    Adipose Tissue/immunology ; Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/physiology ; Cell Separation ; Glucose/metabolism ; Homeodomain Proteins/genetics ; Homeostasis/immunology ; Immunotherapy/methods ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Obese ; Obesity/immunology ; Obesity/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Modulation of taste sensitivity by GLP-1 signaling in taste buds.
    Autorzy:
    Martin B; National Institute on Aging/NIH, Baltimore, Maryland, USA.
    Dotson CD
    Shin YK
    Ji S
    Drucker DJ
    Maudsley S
    Munger SD
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    Źródło:
    Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2009 Jul; Vol. 1170, pp. 98-101.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
    MeSH Terms:
    Signal Transduction*
    Taste*
    Glucagon-Like Peptide 1/*metabolism
    Taste Buds/*metabolism
    Animals ; Glucagon-Like Peptide-1 Receptor ; Mice ; Mice, Knockout ; Receptors, Glucagon/genetics ; Receptors, Glucagon/metabolism ; Receptors, Glucagon/physiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-34 z 34

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