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Tytuł :
Drug development post COVID-19 pandemic: toward a better system to meet current and future global health challenges.
Autorzy :
Aghila Rani KG; Post-doctoral Research Associate, Sharjah Institute of Medical Research, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Hamad MA; Assistant Professor, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Zaher DM; Ph.D Scholar and Graduate Research Assistant, Sharjah Institute of Medical Research, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.
Sieburth SM; Professor, Department of Chemistry, Temple University, Philadelphia, PA, USA.
Madani N; Professor, Department of Microbiology and Immunology, Dana-Farber Cancer Institute, Boston, MA, USA.
Al-Tel TH; Director, Research Institute for Medical & Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
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Źródło :
Expert opinion on drug discovery [Expert Opin Drug Discov] 2021 Apr; Vol. 16 (4), pp. 365-371. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*/epidemiology
Drug Discovery*
SARS-CoV-2*
Drug Development/*trends
Drug Development/economics ; Drug Industry/economics ; Drug Industry/trends ; Global Health ; Health Care Sector/trends ; Health Priorities/economics ; Humans ; Time Factors
Czasopismo naukowe
Tytuł :
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions.
Autorzy :
Bakowski MA; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA. .
Beutler N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Wolff KC; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Kirkpatrick MG; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Chen E; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Nguyen TH; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Riva L; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Shaabani N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Parren M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Ricketts J; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Gupta AK; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Pan K; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Kuo P; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Fuller M; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA.; HUMANOID CoRE, UC San Diego, La Jolla, CA, USA.
Garcia E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Teijaro JR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Yang L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Sahoo D; Department of Computer Science and Engineering, Jacobs School of Engineering, UC San Diego, La Jolla, CA, USA.; Department of Pediatrics, UC San Diego, La Jolla, CA, USA.
Chi V; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Huang E; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Vargas N; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Roberts AJ; Animal Models Core Facility, The Scripps Research Institute, La Jolla, CA, USA.
Das S; HUMANOID CoRE, UC San Diego, La Jolla, CA, USA.; Department of Pathology, UC San Diego, La Jolla, CA, USA.
Ghosh P; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA.; HUMANOID CoRE, UC San Diego, La Jolla, CA, USA.; Department of Medicine, UC San Diego, La Jolla, CA, USA.
Woods AK; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Joseph SB; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Hull MV; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Schultz PG; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Chatterjee AK; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
McNamara CW; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA.
Rogers TF; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. .; UC San Diego Division of Infectious Diseases and Global Public Health, UC San Diego School of Medicine, La Jolla, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 03; Vol. 12 (1), pp. 3309. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Pandemics*
SARS-CoV-2*/drug effects
SARS-CoV-2*/physiology
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Drug Repositioning/*methods
Animals ; COVID-19/prevention & control ; COVID-19/virology ; Cell Line ; Cytidine/administration & dosage ; Cytidine/analogs & derivatives ; Cytidine/pharmacology ; Databases, Pharmaceutical ; Drug Discovery/methods ; Drug Evaluation, Preclinical/methods ; HeLa Cells ; High-Throughput Screening Assays/methods ; Humans ; Hydroxylamines/administration & dosage ; Hydroxylamines/pharmacology ; Mesocricetus ; Nelfinavir/pharmacology ; Virus Replication/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Sensitization of MCF7 Cells with High Notch1 Activity by Cisplatin and Histone Deacetylase Inhibitors Applied Together.
Autorzy :
Wawruszak A; Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Luszczki J; Department of Pathophysiology, Medical University, 20-090 Lublin, Poland.
Halasa M; Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Okon E; Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Landor S; Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, 20500 Turku, Finland.
Sahlgren C; Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, 20500 Turku, Finland.; Turku Bioscience Centre, Åbo Akademi University and University of Turku, 20500 Turku, Finland.; Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612 Eindhoven, The Netherlands.
Rivero-Muller A; Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Stepulak A; Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 13; Vol. 22 (10). Date of Electronic Publication: 2021 May 13.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Interactions*
Breast Neoplasms/*drug therapy
Cisplatin/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Histone Deacetylase Inhibitors/*pharmacology
Receptor, Notch1/*metabolism
Antineoplastic Agents/pharmacology ; Apoptosis ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Drug Synergism ; Drug Therapy, Combination ; Female ; Humans ; MCF-7 Cells ; Receptor, Notch1/genetics
Czasopismo naukowe
Tytuł :
Drug repurposing approach to combating coronavirus: Potential drugs and drug targets.
Autorzy :
Xu J; Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA.
Xue Y; Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA.
Zhou R; Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA.
Shi PY; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Li H; Wadsworth Center, New York State Department of Health, Albany, New York, USA.; Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York, USA.
Zhou J; Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA.
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Źródło :
Medicinal research reviews [Med Res Rev] 2021 May; Vol. 41 (3), pp. 1375-1426. Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Drug Repositioning*
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Antiviral Agents/pharmacology ; COVID-19/virology ; Drug Delivery Systems ; Humans ; SARS-CoV-2/drug effects ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/therapeutic use
Czasopismo naukowe
Tytuł :
Network controllability-based algorithm to target personalized driver genes for discovering combinatorial drugs of individual patients.
Autorzy :
Guo WF; Key Laboratory of Information Fusion Technology of Ministry of Education, School of Automation, Northwestern Polytechnical University, Xian 710072, China.; School of Electrical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Zhang SW; Key Laboratory of Information Fusion Technology of Ministry of Education, School of Automation, Northwestern Polytechnical University, Xian 710072, China.
Feng YH; Key Laboratory of Information Fusion Technology of Ministry of Education, School of Automation, Northwestern Polytechnical University, Xian 710072, China.
Liang J; School of Electrical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Zeng T; CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy Science, Shanghai 200031, China.
Chen L; Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy Science, Shanghai 200031, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China.; Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou 310024, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Apr 19; Vol. 49 (7), pp. e37.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Algorithms*
Drug Therapy, Combination*
Breast Neoplasms/*drug therapy
Breast Neoplasms/*genetics
Lung Neoplasms/*drug therapy
Lung Neoplasms/*genetics
Precision Medicine/*methods
Breast Neoplasms/classification ; COVID-19/drug therapy ; COVID-19/genetics ; Datasets as Topic ; Drug Repositioning ; Drug Synergism ; Drug-Related Side Effects and Adverse Reactions ; Gene Expression Regulation, Neoplastic/genetics ; Genes, Neoplasm/genetics ; Humans ; Risk Assessment ; Workflow
Czasopismo naukowe
Tytuł :
Potential Drug Interactions of Repurposed COVID-19 Drugs with Lung Cancer Pharmacotherapies.
Autorzy :
Baburaj G; Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Thomas L; Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Rao M; Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address: .
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Źródło :
Archives of medical research [Arch Med Res] 2021 Apr; Vol. 52 (3), pp. 261-269. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Repositioning*
Antineoplastic Agents/*pharmacology
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Lung Neoplasms/*drug therapy
SARS-CoV-2/*pathogenicity
COVID-19/epidemiology ; Drug Interactions ; Humans ; Pandemics
Czasopismo naukowe
Tytuł :
New drugs and pharmacological interactions in real life.
Autorzy :
Stathis A; New Drugs Development Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
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Źródło :
Hematological oncology [Hematol Oncol] 2021 Jun; Vol. 39 Suppl 1, pp. 78-82.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Approval*
Antineoplastic Agents/*therapeutic use
Hematologic Neoplasms/*drug therapy
Lymphoproliferative Disorders/*drug therapy
Antineoplastic Agents/adverse effects ; Drug Interactions ; Humans
Czasopismo naukowe
Tytuł :
Chitosan-based systems aimed at local application for vaginal infections.
Autorzy :
Araujo VHS; School of Pharmaceutical Sciences, São Paulo State University, Araraquara, SP, Brazil. Electronic address: .
de Souza MPC; School of Pharmaceutical Sciences, São Paulo State University, Araraquara, SP, Brazil.
Carvalho GC; School of Pharmaceutical Sciences, São Paulo State University, Araraquara, SP, Brazil.
Duarte JL; School of Pharmaceutical Sciences, São Paulo State University, Araraquara, SP, Brazil.
Chorilli M; School of Pharmaceutical Sciences, São Paulo State University, Araraquara, SP, Brazil. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2021 Jun 01; Vol. 261, pp. 117919. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Carriers*/chemical synthesis
Drug Carriers*/chemistry
Drug Carriers*/pharmacokinetics
Anti-Infective Agents, Local/*administration & dosage
Chitosan/*chemistry
Reproductive Tract Infections/*drug therapy
Vaginal Diseases/*drug therapy
Administration, Intravaginal ; Anti-Infective Agents, Local/pharmacokinetics ; Biocompatible Materials/chemical synthesis ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacokinetics ; Chitosan/chemical synthesis ; Chitosan/pharmacokinetics ; Drug Delivery Systems ; Female ; Humans ; Materials Testing ; Reproductive Tract Infections/metabolism ; Vaginal Diseases/metabolism
Czasopismo naukowe
Tytuł :
Deubiquitinating enzyme inhibitor alleviates cyclin A1-mediated proteasome inhibitor tolerance in mixed-lineage leukemia.
Autorzy :
Ge M; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xu Q; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kang T; Department of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li D; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang R; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen Z; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xie S; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang W; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu H; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Jun; Vol. 112 (6), pp. 2287-2298. Date of Electronic Publication: 2021 Apr 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Tolerance*/genetics
Cyclin A1/*metabolism
Deubiquitinating Enzymes/*antagonists & inhibitors
Leukemia, Biphenotypic, Acute/*drug therapy
Proteasome Inhibitors/*pharmacology
Cell Cycle Checkpoints/drug effects ; Cell Cycle Checkpoints/genetics ; Cell Line, Tumor ; Chromatin/metabolism ; Cyclin A1/genetics ; Drug Resistance, Neoplasm ; Gene Expression Regulation, Neoplastic ; Histones/metabolism ; Humans ; Leukemia, Biphenotypic, Acute/genetics ; Leukemia, Biphenotypic, Acute/metabolism ; Leukemia, Biphenotypic, Acute/pathology ; Methylation ; Myeloid-Lymphoid Leukemia Protein/genetics ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Prognosis ; Proteasome Inhibitors/therapeutic use ; Ubiquitination
Czasopismo naukowe
Tytuł :
Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system.
Autorzy :
Wang J; Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Li Q; Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Chen Z; Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Qi X; Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Wu X; Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Di G; School of Basic Medicine, Qingdao University, Qingdao 266071, China.
Fan J; Department of Pharmaceutical Analysis, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Guo C; Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 May 15; Vol. 419, pp. 115511. Date of Electronic Publication: 2021 Apr 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Carriers*
Nanoparticles*
Antineoplastic Agents, Phytogenic/*pharmacology
Breast Neoplasms/*drug therapy
Diterpenes, Kaurane/*chemistry
Hesperidin/*pharmacology
Administration, Oral ; Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacokinetics ; Apoptosis/drug effects ; Biological Availability ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Compounding ; Drug Liberation ; Female ; Hesperidin/administration & dosage ; Hesperidin/chemistry ; Hesperidin/pharmacokinetics ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Micelles ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Solubility ; Tissue Distribution ; Tumor Burden/drug effects
Czasopismo naukowe
Tytuł :
Therapeutic potential of phosphodiesterase inhibitors in the treatment of osteoporosis: Scopes for therapeutic repurposing and discovery of new oral osteoanabolic drugs.
Autorzy :
Porwal K; Division of Endocrinology and Centre for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), India.
Pal S; Division of Endocrinology and Centre for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), India.
Bhagwati S; Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, Sector 10/1 Jankipuram Extension, Sitapur Road, Lucknow, 226 031, India.
Siddiqi MI; Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, Sector 10/1 Jankipuram Extension, Sitapur Road, Lucknow, 226 031, India.
Chattopadhyay N; Division of Endocrinology and Centre for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), India. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 May 15; Vol. 899, pp. 174015. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Repositioning*
Bone and Bones/*drug effects
Osteogenesis/*drug effects
Osteoporosis/*drug therapy
Phosphodiesterase 4 Inhibitors/*administration & dosage
Phosphodiesterase 5 Inhibitors/*administration & dosage
Administration, Oral ; Animals ; Bone Density/drug effects ; Bone Remodeling/drug effects ; Bone and Bones/enzymology ; Bone and Bones/pathology ; Bone and Bones/physiopathology ; Drug Design ; Humans ; Molecular Structure ; Osteoblasts/drug effects ; Osteoblasts/enzymology ; Osteoblasts/pathology ; Osteoclasts/drug effects ; Osteoclasts/enzymology ; Osteoclasts/pathology ; Osteoporosis/enzymology ; Osteoporosis/pathology ; Osteoporosis/physiopathology ; Phosphodiesterase 4 Inhibitors/adverse effects ; Phosphodiesterase 5 Inhibitors/adverse effects ; Signal Transduction ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- and BCRP-Mediated Multidrug Resistance.
Autorzy :
Qiu Q; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Zou F; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Li H; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Shi W; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Zhou D; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Zhang P; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Li T; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Yin Z; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Cai Z; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Jiang Y; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Huang W; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, PR China.
Qian H; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, PR China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 6179-6197. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Benzene/*chemistry
Benzene/*pharmacology
Drug Resistance, Multiple/*drug effects
Neoplasm Proteins/*metabolism
Pyrimidines/*chemistry
Administration, Oral ; Animals ; Benzene/administration & dosage ; Biological Availability ; Drug Interactions ; Humans ; K562 Cells ; Mice ; Paclitaxel/pharmacokinetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial.
Autorzy :
Syversen SW; Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway.
Goll GL; Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway.
Jørgensen KK; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.
Sandanger Ø; Section of Dermatology, Oslo University Hospital, Oslo, Norway.
Sexton J; Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway.
Olsen IC; Department of Research Support for Clinical Trials, Oslo University Hospital, Oslo, Norway.
Gehin JE; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.
Warren DJ; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
Brun MK; Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.
Klaasen RA; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
Karlsen LN; Department of Gastroenterology, Stavanger University Hospital, Stavanger, Norway.
Noraberg G; Department of Gastroenterology, Hospital of Southern Norway Trust, Arendal, Norway.
Zettel C; Department of Rheumatology, Betanien Hospital, Skien, Norway.
Ljoså MKA; Department of Rheumatology, Ålesund Hospital, Ålesund, Norway.
Haugen AJ; Department of Rheumatology, Østfold Hospital Trust, Moss, Norway.
Njålla RJ; Department of Rheumatology, Nordland Hospital Trust, Bodø, Norway.
Bruun TJ; Department of Rheumatology, University Hospital of North Norway, Tromsø, Norway.
Seeberg KA; Departement of Gastroenterology, Vestfold Hospital Trust, Tønsberg, Norway.
Michelsen B; Division of Rheumatology, Department of Medicine, Hospital of Southern Norway Trust, Kristiansand, Norway.
Strand EK; Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway.
Skorpe S; Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway.
Blomgren IM; Department of Gastroenterology, Fonna Hospital Trust, Haugesund, Norway.
Bragnes YH; Department of Rheumatology, Vestre Viken Hospital Trust, Drammen, Norway.
Dotterud CK; Department of Dermatology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Thune T; Department of Dermatology, Haukeland University Hospital, Bergen, Norway.
Ystrøm CM; Department of Medicine, Innlandet Hospital Trust, Elverum, Norway.
Torp R; Department of Medicine, Innlandet Hospital Trust, Hamar, Norway.
Mielnik P; Department of Neurology, Rheumatology, and Physical Medicine, Førde Hospital Trust, Førde, Norway.
Mørk C; Akershus Dermatology Center, Lørenskog, Norway.
Kvien TK; Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.
Jahnsen J; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.
Bolstad N; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
Haavardsholm EA; Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.
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Źródło :
JAMA [JAMA] 2021 May 04; Vol. 325 (17), pp. 1744-1754.
Typ publikacji :
Clinical Trial, Phase IV; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Monitoring*
Arthritis/*drug therapy
Inflammatory Bowel Diseases/*drug therapy
Infliximab/*therapeutic use
Adult ; Chronic Disease ; Dose-Response Relationship, Drug ; Female ; Humans ; Induction Chemotherapy ; Infliximab/administration & dosage ; Male ; Middle Aged ; Psoriasis/drug therapy ; Remission Induction ; Standard of Care
Czasopismo naukowe
Tytuł :
Multidrug Resistance in Mammals and Fungi-From MDR to PDR: A Rocky Road from Atomic Structures to Transport Mechanisms.
Autorzy :
Khunweeraphong N; Center for Medical Biochemistry, Max Perutz Labs Vienna, Campus Vienna Biocenter, Medical University of Vienna, Dr. Bohr-Gasse 9/2, A-1030 Vienna, Austria.
Kuchler K; Center for Medical Biochemistry, Max Perutz Labs Vienna, Campus Vienna Biocenter, Medical University of Vienna, Dr. Bohr-Gasse 9/2, A-1030 Vienna, Austria.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 30; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Resistance, Multiple*
ATP-Binding Cassette Transporters/*metabolism
Fungal Proteins/*metabolism
Mycoses/*drug therapy
Neoplasms/*drug therapy
Nucleocytoplasmic Transport Proteins/*metabolism
Animals ; Antifungal Agents/pharmacokinetics ; Antifungal Agents/pharmacology ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Drug Resistance, Multiple, Fungal ; Fungi/drug effects ; Fungi/metabolism ; Humans ; Mycoses/metabolism ; Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Molecular Insights into Small-Molecule Drug Discovery for SARS-CoV-2.
Autorzy :
Su H; Bengbu Hospital of Traditional Chinese Medicine, 4339 Huai-shang Road, Bengbu, Anhui, 233080, P. R. China.
Zhou F; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Huang Z; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Ma X; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Natarajan K; Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.
Zhang M; Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, Singapore.
Huang Y; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Su H; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Branch of the Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Apr 26; Vol. 60 (18), pp. 9789-9802. Date of Electronic Publication: 2021 Jan 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Discovery*
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
SARS-CoV-2/*drug effects
Small Molecule Libraries/*pharmacology
Antiviral Agents/chemistry ; COVID-19/metabolism ; Drug Design ; Humans ; Molecular Docking Simulation ; Molecular Targeted Therapy ; SARS-CoV-2/physiology ; Small Molecule Libraries/chemistry ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Multi-conformation representation of Mpro identifies promising candidates for drug repurposing against COVID-19.
Autorzy :
Paul D; Division of Bioinformatics, Bose Institute, P-1/12 CIT Scheme VII M, Kolkata, 700054, India.
Basu D; Division of Bioinformatics, Bose Institute, P-1/12 CIT Scheme VII M, Kolkata, 700054, India.
Ghosh Dastidar S; Division of Bioinformatics, Bose Institute, P-1/12 CIT Scheme VII M, Kolkata, 700054, India. .
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Źródło :
Journal of molecular modeling [J Mol Model] 2021 Apr 17; Vol. 27 (5), pp. 128. Date of Electronic Publication: 2021 Apr 17.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
COVID-19/*drug therapy
Coronavirus 3C Proteases/*antagonists & inhibitors
Drug Evaluation, Preclinical/*methods
SARS-CoV-2/*drug effects
Drug Discovery/methods ; Humans ; Molecular Dynamics Simulation ; Protein Conformation
Czasopismo naukowe
Tytuł :
Fabrication of oral nanovesicle in-situ gel based on Epigallocatechin gallate phospholipid complex: Application in dental anti-caries.
Autorzy :
Xu X; School of Food and Biological Engineering, Key Laboratory of Fermentation Engineering, Ministry of Education, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China.
Dai Z; School of Stomatology, Zhengzhou University, Zhengzhou, China.
Zhang Z; School of Food and Biological Engineering, Key Laboratory of Fermentation Engineering, Ministry of Education, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China.
Kou X; School of Food and Biological Engineering, Key Laboratory of Fermentation Engineering, Ministry of Education, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China.
You X; School of Food and Biological Engineering, Key Laboratory of Fermentation Engineering, Ministry of Education, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China.
Sun H; School of Food and Biological Engineering, Key Laboratory of Fermentation Engineering, Ministry of Education, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China.
Guo H; School of Food and Biological Engineering, Key Laboratory of Fermentation Engineering, Ministry of Education, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China.
Liu M; School of Food and Biological Engineering, Key Laboratory of Fermentation Engineering, Ministry of Education, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China.
Zhu H; School of Food and Biological Engineering, Key Laboratory of Fermentation Engineering, Ministry of Education, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Apr 15; Vol. 897, pp. 173951. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Carriers*
Nanoparticles*
Anti-Bacterial Agents/*pharmacology
Cariostatic Agents/*pharmacology
Catechin/*analogs & derivatives
Dental Caries/*prevention & control
Phospholipids/*chemistry
Staphylococcus aureus/*drug effects
Administration, Oral ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemistry ; Bacterial Adhesion/drug effects ; Biofilms/drug effects ; Biofilms/growth & development ; Cariostatic Agents/administration & dosage ; Cariostatic Agents/chemistry ; Catechin/administration & dosage ; Catechin/chemistry ; Catechin/pharmacology ; Dental Caries/microbiology ; Drug Compounding ; Drug Liberation ; Drug Stability ; Gels ; Kinetics ; Staphylococcus aureus/growth & development
Czasopismo naukowe
Tytuł :
Isolation, Structure Elucidation and In Silico Prediction of Potential Drug-Like Flavonoids from Onosma chitralicum Targeted towards Functionally Important Proteins of Drug-Resistant Bad Bugs.
Autorzy :
Khan SA; Department of Chemistry, Kohat University of Science & Technology, Kohat 26000, Pakistan.
Khan SU; School of Pharmacy, Monash University, Bandar Sunway, Subang Jaya 47500, Malaysia.; Department of Pharmacy, Abasyn University, Ring Road, Peshawar 25120, Pakistan.
Fozia; Biochemistry Department, KMU Institute of Medical Sciences, Kohat 26000, Pakistan.
Ullah N; Department of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan.
Shah M; Department of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan.
Ullah R; Department of Pharmacognosy, College of Pharmacy, King Saud University Riyadh Saudi Arabia, Riyadh 11495, Saudi Arabia.
Ahmad I; Department of Chemistry, Kohat University of Science & Technology, Kohat 26000, Pakistan.
Alotaibi A; Basic Science Department, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 02; Vol. 26 (7). Date of Electronic Publication: 2021 Apr 02.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Drug Resistance, Bacterial*/drug effects
Bacterial Proteins/*antagonists & inhibitors
Boraginaceae/*chemistry
Flavonoids/*chemistry
Flavonoids/*isolation & purification
Salmonella typhi/*drug effects
Staphylococcus aureus/*drug effects
Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Binding Sites ; Drug Evaluation, Preclinical ; Flavonoids/pharmacology ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Salmonella typhi/metabolism ; Staphylococcus aureus/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Monoclonal Antibody Approved to Treat Ebola.
Autorzy :
Aschenbrenner DS; Diane S. Aschenbrenner is an assistant professor at Notre Dame of Maryland University in Baltimore. She also coordinates Drug Watch: .
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Źródło :
The American journal of nursing [Am J Nurs] 2021 Apr 01; Vol. 121 (4), pp. 22.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Approval*
Antibodies, Monoclonal, Humanized/*therapeutic use
Drug-Related Side Effects and Adverse Reactions/*nursing
Ebolavirus/*drug effects
Hemorrhagic Fever, Ebola/*drug therapy
Immunologic Factors/*therapeutic use
Nursing Care/*standards
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Practice Guidelines as Topic ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł :
A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices.
Autorzy :
Verza BS; Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, São Paulo State University (UNESP), Humaita, 1680 Araraquara, São Paulo, Brazil. Electronic address: .
van den Beucken JJJP; Regenerative Biomaterials, Radboudumc, Philips Van Leydenlaan 25, Nijmegen, the Netherlands. Electronic address: .
Brandt JV; Department of Physical Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo 14801-970, Brazil. Electronic address: .
Jafelicci Junior M; Department of Physical Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo 14801-970, Brazil. Electronic address: .
Barão VAR; Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, São Paulo 13414-903, Brazil. Electronic address: .
Piazza RD; Department of Physical Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo 14801-970, Brazil. Electronic address: .
Tagit O; Department of Tumor Immunology, Radboudumc and Radboud Institute for Molecular Life Sciences (RIMLS), Geert Grooteplein Zuid, 28 Nijmegen, the Netherlands. Electronic address: .
Spolidorio DMP; Department of Physiology and Pathology, School of Dentistry at Araraquara, São Paulo State University (UNESP), Araraquara, São Paulo 14801-903, Brazil. Electronic address: .
Vergani CE; Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, São Paulo State University (UNESP), Humaita, 1680 Araraquara, São Paulo, Brazil. Electronic address: .
de Avila ED; Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, São Paulo State University (UNESP), Humaita, 1680 Araraquara, São Paulo, Brazil. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2021 Apr 01; Vol. 257, pp. 117604. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Coated Materials, Biocompatible/*chemistry
Delayed-Action Preparations/*chemistry
Staphylococcus aureus/*drug effects
beta-Cyclodextrins/*chemistry
Acrylic Resins/chemistry ; Anions ; Anti-Bacterial Agents/administration & dosage ; Chitosan/chemistry ; Drug Liberation ; Fibroblasts/drug effects ; Humans ; Hydrogen-Ion Concentration ; Magnetic Resonance Spectroscopy ; Microbial Sensitivity Tests ; Polymers/chemistry ; Prostheses and Implants ; Prosthesis Design ; Surface Properties ; Tetracycline/chemistry ; Titanium/chemistry
Czasopismo naukowe

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