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Wyszukujesz frazę ""Drug Discovery"" wg kryterium: Temat


Tytuł :
Recent omics-based computational methods for COVID-19 drug discovery and repurposing.
Autorzy :
Tayara H; School of international Engineering and Science, Jeonbuk National University, Jeonju 54896, Republic of Korea.
Abdelbaky I; Artificial Intelligence Department, Faculty of Computers and Artificial Intelligence, Benha University, Banha 13518, Egypt.
To Chong K; Department of Electronics and Information Engineering, Jeonbuk National University, Jeonju, Jeollabukdo 54896, Republic of Korea.; Advances Electronics and Information Research Center, Jeonbuk National University, Jeonju 54896, Republic of Korea.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Nov 05; Vol. 22 (6).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Drug Repositioning*
COVID-19/*drug therapy
SARS-CoV-2/*genetics
Algorithms ; Artificial Intelligence ; COVID-19/genetics ; COVID-19/virology ; Genomics/trends ; Humans ; Pandemics ; Proteomics/trends ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Improving Translational Paradigms in Drug Discovery and Development.
Autorzy :
Williams M; Department of Biological Chemistry and Pharmacology, College of Medicine, Ohio State University, Columbus, Ohio.
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Źródło :
Current protocols [Curr Protoc] 2021 Nov; Vol. 1 (11), pp. e273.
Typ publikacji :
Journal Article
MeSH Terms :
Biomedical Research*
Drug Discovery*
Animals ; Drug Approval ; Drug Delivery Systems ; Humans ; Research Design
Czasopismo naukowe
Tytuł :
SARS-CoV-2-host proteome interactions for antiviral drug discovery.
Autorzy :
Liu X; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Huuskonen S; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Laitinen T; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Redchuk T; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Bogacheva M; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Department of Virology, University of Helsinki, Helsinki, Finland.
Salokas K; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Pöhner I; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Öhman T; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Tonduru AK; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Hassinen A; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Gawriyski L; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Keskitalo S; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Vartiainen MK; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Pietiäinen V; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Poso A; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.; Department of Internal Medicine VIII, University Hospital Tübingen, Tübingen, Germany.
Varjosalo M; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
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Źródło :
Molecular systems biology [Mol Syst Biol] 2021 Nov; Vol. 17 (11), pp. e10396.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Host-Pathogen Interactions/*drug effects
Proteome/*drug effects
SARS-CoV-2/*physiology
COVID-19/virology ; Drug Repositioning ; Humans ; Mass Spectrometry ; Methotrexate/pharmacology ; Proteomics ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3).
Autorzy :
Huang Q; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Zhong Y; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Li B; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Ouyang S; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Deng L; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Mo J; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Shi S; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Lv N; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Wu R; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Liu P; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Hu W; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Zhang X; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. Electronic address: .
Wang Y; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 05; Vol. 221, pp. 113525. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Pyridines/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Humans ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Molecular Docking Simulation ; Molecular Structure ; Pyridines/chemical synthesis ; Pyridines/chemistry ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
In silico methods and tools for drug discovery.
Autorzy :
Shaker B; Department of Biomedical Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
Ahmad S; Department of Health and Biological Sciences, Abasyn University, Peshawar, 25000, Pakistan.
Lee J; Department of Biomedical Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
Jung C; Department of Biomedical Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
Na D; Department of Biomedical Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea. Electronic address: .
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Źródło :
Computers in biology and medicine [Comput Biol Med] 2021 Oct; Vol. 137, pp. 104851. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Computer-Aided Design*
Drug Discovery*
Computer Simulation
Czasopismo naukowe
Tytuł :
Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients.
Autorzy :
Marwick JA; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Elliott RJR; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Longden J; Center for Clinical Brain Sciences, Chancellors Building, University of Edinburgh, Edinburgh, UK.
Makda A; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Hirani N; Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Dhaliwal K; Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Dawson JC; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Carragher NO; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Oct; Vol. 26 (9), pp. 1091-1106. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
COVID-19/*drug therapy
Lung/*diagnostic imaging
Small Molecule Libraries/*pharmacology
Apoptosis/drug effects ; COVID-19/epidemiology ; COVID-19/virology ; Cell Differentiation/drug effects ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Extracellular Matrix/drug effects ; Extracellular Matrix/pathology ; Fibroblasts/drug effects ; Humans ; Lung/drug effects ; Lung/pathology ; Lung/virology ; Mass Screening ; Pandemics ; SARS-CoV-2/pathogenicity ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities.
Autorzy :
Shen XB; Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang, 236037, PR China.
Chen X; School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Zhang ZY; School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Wu FF; Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang, 236037, PR China. Electronic address: .
Liu XH; Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang, 236037, PR China; School of Pharmacy, Anhui Medical University, Hefei, 230032, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Dec 05; Vol. 225, pp. 113818. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Discovery*
Anti-Inflammatory Agents/*chemistry
Cathepsin C/*antagonists & inhibitors
Protease Inhibitors/*chemistry
Anti-Inflammatory Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/virology ; Cathepsin C/genetics ; Cathepsin C/metabolism ; Humans ; Papillon-Lefevre Disease/genetics ; Papillon-Lefevre Disease/pathology ; Protease Inhibitors/metabolism ; Protease Inhibitors/therapeutic use ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/pathology ; SARS-CoV-2/isolation & purification ; Serine Endopeptidases/metabolism
Czasopismo naukowe
Tytuł :
Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor.
Autorzy :
Li J; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Zou W; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yu K; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Liu B; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Liang W; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Wang L; Department of Medicinal Chemistry, PharmaBlock Sciences (Nanjing), Inc., Nanjing, China.
Lu Y; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Jiang Z; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Wang A; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Zhu J; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 903-913.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Biological Products/*pharmacology
Cell Cycle Proteins/*antagonists & inhibitors
Transcription Factors/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Structure-Activity Relationship ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Discovery of indole-3-butyric acid derivatives as potent histone deacetylase inhibitors.
Autorzy :
Chen Y; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, Shandong, China.
Zhang L; School of Stomatology, Weifang Medical University, Weifang, Shandong, China.
Zhang L; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, Shandong, China.
Jiang Q; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, Shandong, China.
Zhang L; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, Shandong, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 425-436.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Indoles/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/metabolism ; Liver Neoplasms, Experimental/pathology ; Male ; Mice ; Mice, Nude ; Molecular Structure ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect.
Autorzy :
Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Hawwas MM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Malebari AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Taher ES; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Omar AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Neamatallah T; Department of Pharmacology and toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Abdel-Samii ZK; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Safo MK; Institute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA.
Elshaier YAMM; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 802-818.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Quinolines/*pharmacology
Stilbenes/*pharmacology
Tubulin/*metabolism
Tubulin Modulators/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Polymerization/drug effects ; Quinolines/chemical synthesis ; Quinolines/chemistry ; Reactive Oxygen Species/metabolism ; Stilbenes/chemical synthesis ; Stilbenes/chemistry ; Structure-Activity Relationship ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/chemistry
Czasopismo naukowe
Tytuł :
Discovery of new acetylcholinesterase inhibitors for Alzheimer's disease: virtual screening and in vitro characterisation.
Autorzy :
David B; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Germany, Düsseldorf.
Schneider P; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf at Forschungszentrum Jülich GmbH, Jülich, Germany.
Schäfer P; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf at Forschungszentrum Jülich GmbH, Jülich, Germany.
Pietruszka J; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf at Forschungszentrum Jülich GmbH, Jülich, Germany.; IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, Jülich, Germany.
Gohlke H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Germany, Düsseldorf.; John von Neumann Institute for Computing (NIC), Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Jülich, Germany.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 491-496.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Acetylcholinesterase/*metabolism
Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*pharmacology
Donepezil/*pharmacology
Physostigmine/*pharmacology
Alzheimer Disease/metabolism ; Animals ; Cholinesterase Inhibitors/chemistry ; Donepezil/chemistry ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Electrophorus ; Molecular Docking Simulation ; Molecular Structure ; Physostigmine/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Discovery of facile amides-functionalized rhodanine-3-acetic acid derivatives as potential anticancer agents by disrupting microtubule dynamics.
Autorzy :
Zhou X; State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, People's Republic of China.; College of Pharmacy, Guizhou University, Guiyang, People's Republic of China.
Liu J; College of Pharmacy, Guizhou University, Guiyang, People's Republic of China.
Meng J; State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, People's Republic of China.
Fu Y; College of Pharmacy, Guizhou University, Guiyang, People's Republic of China.
Wu Z; State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, People's Republic of China.
Ouyang G; College of Pharmacy, Guizhou University, Guiyang, People's Republic of China.
Wang Z; State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, People's Republic of China.; College of Pharmacy, Guizhou University, Guiyang, People's Republic of China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1996-2009.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Acetates/*pharmacology
Amides/*pharmacology
Antineoplastic Agents/*pharmacology
Microtubules/*drug effects
Rhodanine/*pharmacology
Tubulin Modulators/*pharmacology
A549 Cells ; Acetates/chemical synthesis ; Acetates/chemistry ; Amides/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Microtubules/metabolism ; Molecular Structure ; Polymerization/drug effects ; Rhodanine/analogs & derivatives ; Rhodanine/chemistry ; Structure-Activity Relationship ; Tubulin/metabolism ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/chemistry
Czasopismo naukowe
Tytuł :
Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation.
Autorzy :
Hagras M; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
El Deeb MA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Elzahabi HSA; Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Elkaeed EB; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah, Riyadh, Saudi Arabia.
Mehany ABM; Department of Zoology, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Eissa IH; Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 640-658.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Molecular Docking Simulation*
Antineoplastic Agents/*pharmacology
Quinolines/*pharmacology
Tubulin Modulators/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Binding Sites/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Colchicine ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Quinolines/chemical synthesis ; Quinolines/chemistry ; Structure-Activity Relationship ; Tubulin/metabolism ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/chemistry
Czasopismo naukowe
Tytuł :
Discovery of orally active chalcones as histone lysine specific demethylase 1 inhibitors for the treatment of leukaemia.
Autorzy :
Li Y; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Sun Y; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Zhou Y; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Li X; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Zhang H; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Zhang G; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 207-217.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Chalcones/*pharmacology
Enzyme Inhibitors/*pharmacology
Histone Demethylases/*antagonists & inhibitors
Leukemia/*drug therapy
Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Chalcones/administration & dosage ; Chalcones/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/chemistry ; Histone Demethylases/metabolism ; Humans ; Leukemia/metabolism ; Leukemia/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3- a :3',4'- c ]quinoxaline derivatives as anticancer agents and apoptosis inducers.
Autorzy :
Alsaif NA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Taghour MS; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Obaidullah AJ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Al-Mehizia AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Aldawas S; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Elwan A; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1093-1114.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Protein Kinase Inhibitors/*pharmacology
Quinoxalines/*pharmacology
Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Quinoxalines/chemical synthesis ; Quinoxalines/chemistry ; Structure-Activity Relationship ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Czasopismo naukowe
Tytuł :
Discovery of potent histone deacetylase inhibitors with modified phenanthridine caps.
Autorzy :
Fan W; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Zhang L; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Wang X; Department of Pharmacology, School of Pharmacy, Weifang Medical University, Weifang, China.
Jia H; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Zhang L; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 707-718.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Phenanthridines/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Molecular Structure ; Phenanthridines/chemical synthesis ; Phenanthridines/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Exploring natural microbial resources for the discovery of anti-malarial compounds.
Autorzy :
Waluyo D; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Prabandari EE; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Pramisandi A; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Hidayati DN; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Chrisnayanti E; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Puspitasari DJ; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Dewi D; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Suryani; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Kristiningrum; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Oktaviani AN; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Afrianti KR; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Nonaka K; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Matsumoto A; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Tokiwa T; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Adipratiwi N; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Ariyani T; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Hartuti ED; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia; School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
Putri TZ; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Rahmawati Y; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Inaoka DK; School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
Miyazaki Y; School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
Sakura T; School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
Nurlaila; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Siska E; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Kurnia K; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Bernawati P; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Melinda; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Mahsunah AH; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Nugroho NB; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia.
Mori M; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Dobashi K; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Yamashita M; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Nurkanto A; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Research Center for Biology, Indonesia Institute of Science (LIPI), Cibinong, Indonesia.
Watanabe A; MicroBiopharm Japan Co., Ltd, Tokyo, Japan.
Shiomi K; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Wibowo AE; Laboratory for Biotechnology (Biotech Center), Agency for the Assessment and Application of Technology (BPPT), Building 630, Puspiptek Area, Setu, South Tangerang 15314, Banten, Indonesia; Center for Pharmaceutical and Medical Technology, Agency for the Assessment and Application of Technology (BPPT), Laptiab, Puspiptek, Setu, South Tangerang 15314, Banten, Indonesia.
Nozaki T; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address: .
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Źródło :
Parasitology international [Parasitol Int] 2021 Dec; Vol. 85, pp. 102432. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antimalarials/*isolation & purification
Antimalarials/*pharmacology
Plasmodium falciparum/*drug effects
Indonesia
Czasopismo naukowe
Tytuł :
New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011-2021) focussing on structure-activity relationship (SAR) and docking insights.
Autorzy :
Elkamhawy A; College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Ali EMH; Center for Biomaterials, Korea Institute of Science & Technology (KIST School), Seoul, Republic of Korea.; University of Science & Technology (UST), Daejeon, Republic of Korea.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt.
Lee K; College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1574-1602.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Discovery*
Molecular Docking Simulation*
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Dose-Response Relationship, Drug ; Humans ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening.
Autorzy :
Hoarau M; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
Vanichtanankul J; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
Srimongkolpithak N; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
Vitsupakorn D; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
Yuthavong Y; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
Kamchonwongpaisan S; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, Thailand.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 198-206.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antimalarials/*pharmacology
Enzyme Inhibitors/*pharmacology
Plasmodium falciparum/*drug effects
Protozoan Proteins/*antagonists & inhibitors
Antimalarials/chemical synthesis ; Antimalarials/chemistry ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Plasmodium falciparum/enzymology ; Proguanil/chemical synthesis ; Proguanil/chemistry ; Proguanil/pharmacology ; Protozoan Proteins/isolation & purification ; Protozoan Proteins/metabolism ; Pyrimethamine/chemical synthesis ; Pyrimethamine/chemistry ; Pyrimethamine/pharmacology ; Structure-Activity Relationship ; Tetrahydrofolate Dehydrogenase/isolation & purification ; Tetrahydrofolate Dehydrogenase/metabolism ; Triazines/chemical synthesis ; Triazines/chemistry ; Triazines/pharmacology
Czasopismo naukowe
Tytuł :
Evaluation of FOXO1 Target Engagement Using a Single-Cell Microfluidic Platform.
Autorzy :
Osman S; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, 80 Wood Lane, London, W12 0BZ, United Kingdom.
Bendtsen C; Discovery Sciences, R&D, AstraZeneca, 310 Milton Road, Cambridge, CB4 0WG, United Kingdom.
Peel S; Discovery Sciences, R&D, AstraZeneca, 310 Milton Road, Cambridge, CB4 0WG, United Kingdom.
Yrlid L; Early Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43150 Gothenburg, Sweden.
Muthas D; Early Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43150 Gothenburg, Sweden.
Simpson J; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, 80 Wood Lane, London, W12 0BZ, United Kingdom.
Willison KR; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, 80 Wood Lane, London, W12 0BZ, United Kingdom.
Klug DR; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, 80 Wood Lane, London, W12 0BZ, United Kingdom.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Nov 09; Vol. 93 (44), pp. 14659-14666. Date of Electronic Publication: 2021 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Microfluidics*
Proteins
Czasopismo naukowe

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