Temat: "Drug Evaluation" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Analysis of post-market adverse events of istradefylline: a real-world study base on FAERS database.
Autorzy:: Jiang Y; Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China.
Lu R; Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China.
Zhou Q; Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China.
Shen Y; Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China. .
Zhu H; Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Apr 01; Vol. 14 (1), pp. 7659. Date of Electronic Publication: 2024 Apr 01.
Typ publikacji:: Journal Article
MeSH Terms:: Compulsive Behavior*
Purines*/adverse effects
United States ; Databases, Factual ; Drug Evaluation, Preclinical ; United States Food and Drug Administration

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Skocz do pozycji: 2.

Tytuł:: Detection of biomagnetic signals from induced pluripotent stem cell-derived cardiomyocytes using deep learning with simulation data.
Autorzy:: Yamaguchi T; Department of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan. .; Applied Electronics Laboratory, Kanazawa Institute of Technology, Ishikawa, 920-1331, Japan. .
Adachi Y; Applied Electronics Laboratory, Kanazawa Institute of Technology, Ishikawa, 920-1331, Japan.
Tanida T; Department of Veterinary Anatomy, Graduate School of Veterinary Science, Osaka Metropolitan University, Osaka, 598-8531, Japan.
Taguchi K; Department of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Oka Y; Department of Pediatric Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Yoshida T; Department of Orthopaedic Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, 629-2261, Japan.
Kim WC; Department of Pediatric Orthopaedic Surgery and Ilizarov Center, Uji Takeda Hospital, Kyoto, 611-0021, Japan.
Takahashi K; Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Tanaka M; Department of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Mar 27; Vol. 14 (1), pp. 7296. Date of Electronic Publication: 2024 Mar 27.
Typ publikacji:: Journal Article
MeSH Terms:: Induced Pluripotent Stem Cells*
Deep Learning*
Animals ; Mice ; Myocytes, Cardiac ; Isoproterenol/pharmacology ; Drug Evaluation, Preclinical ; Cell Differentiation

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Skocz do pozycji: 3.

Tytuł:: Identification of Novel Antimicrobial Compounds Targeting Mycobacterium tuberculosis S -Adenosyl-L-Homocysteine Hydrolase Using Dual Hierarchical In Silico Structure-Based Drug Screening.
Autorzy:: Ito H; Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka 820-8502, Japan.
Monobe K; Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka 820-8502, Japan.
Okubo S; Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka 820-8502, Japan.
Aoki S; Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka 820-8502, Japan.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Mar 14; Vol. 29 (6). Date of Electronic Publication: 2024 Mar 14.
Typ publikacji:: Journal Article
MeSH Terms:: Mycobacterium tuberculosis*
Tuberculosis*/microbiology
Humans ; Antitubercular Agents/chemistry ; Drug Evaluation, Preclinical ; Homocysteine/pharmacology ; Hydrolases/pharmacology ; Molecular Docking Simulation

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Skocz do pozycji: 4.

Tytuł:: Construction of luciferase-expressing Neospora caninum and drug screening.
Autorzy:: Wang F; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Xue Y; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Pei Y; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Yin M; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Sun Z; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Zhou Z; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Liu J; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Liu Q; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. .; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. .; Pokaż więcej
Źródło:: Parasites & vectors [Parasit Vectors] 2024 Mar 08; Vol. 17 (1), pp. 118. Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:: Journal Article
MeSH Terms:: Coccidiosis*/drug therapy
Coccidiosis*/veterinary
Coccidiosis*/parasitology
Neospora*/genetics
Cattle Diseases*
Dog Diseases*
Rodent Diseases*
Nitriles*
Pregnancy ; Female ; Animals ; Mice ; Cattle ; Dogs ; Drug Evaluation, Preclinical ; Benzothiazoles/metabolism ; Benzothiazoles/pharmacology ; Benzothiazoles/therapeutic use

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Skocz do pozycji: 5.

Tytuł:: Using birth-death processes to infer tumor subpopulation structure from live-cell imaging drug screening data.
Autorzy:: Wu C; Department of Industrial and Systems Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.
Gunnarsson EB; School of Mathematics, University of Minnesota, Minneapolis, Minnesota, United States of America.; Applied Mathematics Division, Science Institute, University of Iceland, Reykjavík, Iceland.
Myklebust EM; Oslo Centre for Biostatistics and Epidemiology, Faculty of Medicine, University of Oslo, Oslo, Norway.
Köhn-Luque A; Oslo Centre for Biostatistics and Epidemiology, Faculty of Medicine, University of Oslo, Oslo, Norway.; Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.
Tadele DS; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Enserink JM; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Section for Biochemistry and Molecular Biology, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Frigessi A; Oslo Centre for Biostatistics and Epidemiology, Faculty of Medicine, University of Oslo, Oslo, Norway.
Foo J; School of Mathematics, University of Minnesota, Minneapolis, Minnesota, United States of America.
Leder K; Department of Industrial and Systems Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2024 Mar 06; Vol. 20 (3), pp. e1011888. Date of Electronic Publication: 2024 Mar 06 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Neoplasms*/drug therapy
Neoplasms*/pathology
Genetic Phenomena*
Humans ; Drug Evaluation, Preclinical

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Skocz do pozycji: 6.

Tytuł:: A Zebrafish-Based Platform for High-Throughput Epilepsy Modeling and Drug Screening in F0.
Autorzy:: Locubiche S; ZeClinics S.L., Carrer de Laureà Miró, 408-410, 08980 Sant Feliu de Llobregat, Spain.; Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08036 Barcelona, Spain.
Ordóñez V; ZeClinics S.L., Carrer de Laureà Miró, 408-410, 08980 Sant Feliu de Llobregat, Spain.
Abad E; ZeClinics S.L., Carrer de Laureà Miró, 408-410, 08980 Sant Feliu de Llobregat, Spain.
Scotto di Mase M; ZeClinics S.L., Carrer de Laureà Miró, 408-410, 08980 Sant Feliu de Llobregat, Spain.
Di Donato V; ZeClinics S.L., Carrer de Laureà Miró, 408-410, 08980 Sant Feliu de Llobregat, Spain.
De Santis F; ZeClinics S.L., Carrer de Laureà Miró, 408-410, 08980 Sant Feliu de Llobregat, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 04; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:: Journal Article
MeSH Terms:: Zebrafish*/genetics
Epilepsy*/genetics
Animals ; Humans ; Drug Evaluation, Preclinical ; Mutation ; CRISPR-Cas Systems

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Skocz do pozycji: 7.

Tytuł:: Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy.
Autorzy:: Hussain R; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.
Lim CX; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.; Pharmacy, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, 3083, Australia.
Shaukat Z; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.
Islam A; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.; College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia.
Caseley EA; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
Lippiat JD; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
Rychkov GY; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.; School of Biomedicine, University of Adelaide, Adelaide, SA, 5005, Australia.; South Australian Health and Medical Research Institute, Adelaide, SA, 5005, Australia.
Ricos MG; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.
Dibbens LM; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 09; Vol. 14 (1), pp. 3357. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Drosophila*/genetics
Epilepsy*/drug therapy
Epilepsy*/genetics
Potassium Channels, Sodium-Activated*/genetics
Animals ; Humans ; Drosophila melanogaster/genetics ; Drug Evaluation, Preclinical ; Models, Animal ; Mutation ; Nerve Tissue Proteins/genetics ; Seizures/drug therapy ; Seizures/genetics ; Transgenes

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Skocz do pozycji: 8.

Tytuł:: Integrating cfDNA liquid biopsy and organoid-based drug screening reveals PI3K signaling as a promising therapeutic target in colorectal cancer.
Autorzy:: Yang H; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.; Guangdong Provincial Key Laboratory of Digestive Cancer Research, Shenzhen, Guangdong, China.
Xiao X; Guangdong Provincial Key Laboratory of Digestive Cancer Research, Shenzhen, Guangdong, China.
Zeng L; Department of Biobank, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China.
Zeng H; Guangdong Provincial Key Laboratory of Digestive Cancer Research, Shenzhen, Guangdong, China.
Zheng Y; Clinical Big Data Research Center, Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
Wang J; Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Li G; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Dai W; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
He Y; Guangdong Provincial Key Laboratory of Digestive Cancer Research, Shenzhen, Guangdong, China.; Department of Gastrointestinal Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China.
Wang S; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China. .
Peng J; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. .
Chen W; Guangdong Provincial Key Laboratory of Digestive Cancer Research, Shenzhen, Guangdong, China. .; Department of Gastrointestinal Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2024 Feb 03; Vol. 22 (1), pp. 132. Date of Electronic Publication: 2024 Feb 03.
Typ publikacji:: Journal Article
MeSH Terms:: Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/diagnosis
Cell-Free Nucleic Acids*
Humans ; Phosphatidylinositol 3-Kinases/genetics ; Drug Evaluation, Preclinical ; Proto-Oncogene Proteins p21(ras)/genetics ; Early Detection of Cancer ; Liquid Biopsy ; Phosphoinositide-3 Kinase Inhibitors ; Biomarkers ; Class I Phosphatidylinositol 3-Kinases/genetics ; Mutation/genetics

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Skocz do pozycji: 9.

Tytuł:: An animal-free preclinical drug screening platform based on human precision-cut kidney slices.
Autorzy:: Mutsaers HAM; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark. .
Jensen MS; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.
Kresse JC; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.
Tingskov SJ; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.
Madsen MG; Department of Urology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.
Nørregaard R; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.; Pokaż więcej
Źródło:: BMC research notes [BMC Res Notes] 2023 Mar 20; Vol. 16 (1), pp. 39. Date of Electronic Publication: 2023 Mar 20.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Evaluation, Preclinical*/methods
Kidney Diseases*/drug therapy
Renal Insufficiency, Chronic*
Animals ; Humans ; Fibrosis ; Kidney/pathology ; Transforming Growth Factor beta/genetics ; Animal Testing Alternatives

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Skocz do pozycji: 10.

Tytuł:: Indictment of monkey importers could disrupt U.S. research.
Autorzy:: Grimm D; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Dec 02; Vol. 378 (6623), pp. 934-935. Date of Electronic Publication: 2022 Dec 01.
Typ publikacji:: Wiadomości
MeSH Terms:: Drug Evaluation*
Crime*
Macaca fascicularis*
Animal Experimentation*
Animals ; Cambodia

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Skocz do pozycji: 11.

Tytuł:: Statistical integration of multi-omics and drug screening data from cell lines.
Autorzy:: El Bouhaddani S; Dept. Data science & Biostatistics, UMC Utrecht, Utrecht, Netherlands.
Höllerhage M; Department of Neurology, Hannover Medical School, Hannover, Germany.
Uh HW; Dept. Data science & Biostatistics, UMC Utrecht, Utrecht, Netherlands.
Moebius C; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Bickle M; Roche Institute for Translational Bioengineering, Basel, Switzerland.
Höglinger G; Department of Neurology, Hannover Medical School, Hannover, Germany.; Department of Neurology, Ludwig-Maximilians-Universität, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Houwing-Duistermaat J; Dept. Data science & Biostatistics, UMC Utrecht, Utrecht, Netherlands.; Dept. of Mathematics, Radboud University, Nijmegen, Netherlands.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2024 Jan 31; Vol. 20 (1), pp. e1011809. Date of Electronic Publication: 2024 Jan 31 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Computational Biology*/methods
Synucleinopathies*
Humans ; Multiomics ; Drug Evaluation, Preclinical ; Proteomics/methods

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Skocz do pozycji: 12.

Tytuł:: Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells by WNT Switch Method.
Autorzy:: Mensah IK; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Emerson ML; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Tan HJ; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Gowher H; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.; Pokaż więcej
Źródło:: Cells [Cells] 2024 Jan 11; Vol. 13 (2). Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mouse Embryonic Stem Cells*
Myocytes, Cardiac*
Retinal Degeneration*
Vision Disorders*
Eye Diseases, Hereditary*
Animals ; Mice ; Cell Differentiation ; Drug Evaluation, Preclinical ; Mammals
SCR Disease Name:: Enhanced S-Cone Syndrome

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Skocz do pozycji: 13.

Tytuł:: Immunophenotyping of hemocytes from infected Galleria mellonella larvae as an innovative tool for immune profiling, infection studies and drug screening.
Autorzy:: Gallorini M; Department of Pharmacy, 'G. d' Annunzio' University of Chieti-Pescara, 66100, Chieti, Italy. .
Marinacci B; Department of Pharmacy, 'G. d' Annunzio' University of Chieti-Pescara, 66100, Chieti, Italy.; Department of Innovative Technologies in Medicine & Dentistry, 'G. d'Annunzio' University of Chieti-Pescara, 66100, Chieti, Italy.
Pellegrini B; Department of Pharmacy, 'G. d' Annunzio' University of Chieti-Pescara, 66100, Chieti, Italy.
Cataldi A; Department of Pharmacy, 'G. d' Annunzio' University of Chieti-Pescara, 66100, Chieti, Italy.; UdA TechLab, 'G. d' Annunzio' University of Chieti-Pescara, 66100, Chieti, Italy.
Dindo ML; Department of Agricultural and Food Sciences, University of Bologna, 40127, Bologna, Italy.
Carradori S; Department of Pharmacy, 'G. d' Annunzio' University of Chieti-Pescara, 66100, Chieti, Italy.
Grande R; Department of Pharmacy, 'G. d' Annunzio' University of Chieti-Pescara, 66100, Chieti, Italy. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jan 08; Vol. 14 (1), pp. 759. Date of Electronic Publication: 2024 Jan 08.
Typ publikacji:: Journal Article
MeSH Terms:: Hemocytes*
Moths*
Animals ; Humans ; Larva ; Drug Evaluation, Preclinical ; Immunophenotyping ; Reproducibility of Results ; Mammals

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Skocz do pozycji: 14.

Tytuł:: A tutorial for model-based evaluation and translation of cardiovascular safety in preclinical trials.
Autorzy:: Kulesh V; Modeling & Simulation Decisions FZ-LLC, Dubai, United Arab Emirates.; Research Center of Model-Informed Drug Development, Sechenov First Moscow State Medical University, Moscow, Russia.
Vasyutin I; Modeling & Simulation Decisions FZ-LLC, Dubai, United Arab Emirates.
Volkova A; Modeling & Simulation Decisions FZ-LLC, Dubai, United Arab Emirates.; Sirius University of Science and Technology, Sirius, Russia.
Peskov K; Modeling & Simulation Decisions FZ-LLC, Dubai, United Arab Emirates.; Research Center of Model-Informed Drug Development, Sechenov First Moscow State Medical University, Moscow, Russia.; Sirius University of Science and Technology, Sirius, Russia.
Kimko H; CPQP, CPSS, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.
Sokolov V; Modeling & Simulation Decisions FZ-LLC, Dubai, United Arab Emirates.; Sirius University of Science and Technology, Sirius, Russia.
Alluri R; CPQP, CPSS, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Pokaż więcej
Źródło:: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Jan; Vol. 13 (1), pp. 5-22. Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:: Journal Article
MeSH Terms:: Drug-Related Side Effects and Adverse Reactions*
Animals ; Humans ; Drug Evaluation, Preclinical ; Blood Pressure ; Hemodynamics ; Heart Rate

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Skocz do pozycji: 15.

Tytuł:: Generating Patient-Derived HCC Cell Lines Suitable for Predictive In Vitro and In Vivo Drug Screening by Orthotopic Transplantation.
Autorzy:: Staffeldt L; Institute of Anatomy and Experimental Morphology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Mattert G; Brandenburg Medical School, Center for Translational Medicine, 14770 Brandenburg an der Havel, Germany.
Riecken K; Research Department Cell and Gene Therapy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Rövenstrunk G; Brandenburg Medical School, Center for Translational Medicine, 14770 Brandenburg an der Havel, Germany.
Volkmar A; Brandenburg Medical School, Center for Translational Medicine, 14770 Brandenburg an der Havel, Germany.
Heumann A; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Moustafa M; Department of Visceral Transplantation, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Jücker M; Center for Experimental Medicine, Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Fehse B; Research Department Cell and Gene Therapy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; German Center for Infection Research, Hamburg-Lübeck-Borstel Partner Site, 38124 Braunschweig, Germany.
Schumacher U; Institute of Anatomy and Experimental Morphology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Medical School Berlin, Mecklenburgische Straße 57, 14197 Berlin, Germany.
Lüth S; Brandenburg Medical School, Center for Translational Medicine, 14770 Brandenburg an der Havel, Germany.; Department of Gastroenterology, University Hospital Brandenburg, 14770 Brandenburg an der Havel, Germany.
Kah J; Institute of Anatomy and Experimental Morphology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Brandenburg Medical School, Center for Translational Medicine, 14770 Brandenburg an der Havel, Germany.; Department of Gastroenterology, University Hospital Brandenburg, 14770 Brandenburg an der Havel, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Dec 30; Vol. 13 (1). Date of Electronic Publication: 2023 Dec 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carcinoma, Hepatocellular*/drug therapy
Liver Neoplasms*/drug therapy
Humans ; Animals ; Mice ; Drug Evaluation, Preclinical ; Transplantation, Heterologous ; Cell Line

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Skocz do pozycji: 16.

Tytuł:: Computational Screening and Experimental Validation of Inhibitor Targeting the Complex Formation of Grb14 and Insulin Receptor.
Autorzy:: Ochi Y; Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka 820-8502, Japan.
Matsui T; Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830-0011, Japan.
Inoue K; Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka 820-8502, Japan.
Monobe K; Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka 820-8502, Japan.
Sakamoto H; Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka 820-8502, Japan.
Aoki S; Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka 820-8502, Japan.
Taira J; Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka 820-8502, Japan.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Dec 29; Vol. 29 (1). Date of Electronic Publication: 2023 Dec 29.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Type 2*/drug therapy
Insulin Resistance*
Humans ; Receptor, Insulin/genetics ; Drug Evaluation, Preclinical ; Protein-Tyrosine Kinases ; RNA

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Skocz do pozycji: 17.

Tytuł:: Discovery of potent heat shock protein 90 (Hsp90) inhibitors: structure-based virtual screening, molecular dynamics simulation, and biological evaluation.
Autorzy:: Xu Y; Department of Pharmacy, Nantong First People's Hospital, Nantong, China.
Zou Y; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Zhou S; Department of Pharmacy, Nantong First People's Hospital, Nantong, China.
Niu MM; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Zhang Y; Department of Oncology, Urology and Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Li J; Department of Oncology, Urology and Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Xu Z; Department of Oncology, Urology and Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Yang L; Department of Oncology, Urology and Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2220558.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Discovery*
HSP90 Heat-Shock Proteins*/antagonists & inhibitors
Cell Line, Tumor ; Drug Evaluation, Preclinical/methods ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Docking Simulation ; Pharmacophore ; Humans ; Animals ; Mice

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na półce

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Skocz do pozycji: 18.

Tytuł:: GraphGPT: A Graph Enhanced Generative Pretrained Transformer for Conditioned Molecular Generation.
Autorzy:: Lu H; College of Computer Science and Technology, Ocean University of China, Qingdao 266100, China.
Wei Z; College of Computer Science and Technology, Ocean University of China, Qingdao 266100, China.
Wang X; College of Computer Science and Technology, Ocean University of China, Qingdao 266100, China.
Zhang K; College of Computer Science and Technology, Ocean University of China, Qingdao 266100, China.
Liu H; College of Computer Science and Technology, Ocean University of China, Qingdao 266100, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 25; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 25.
Typ publikacji:: Journal Article
MeSH Terms:: Benchmarking*
Drug Discovery*
Drug Evaluation, Preclinical ; Electric Power Supplies

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na półce

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Skocz do pozycji: 19.

Tytuł:: A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine.
Autorzy:: Steinberg E; The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Friedman R; School of Computer Science and Engineering, Center for Interdisciplinary Data Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
Goldstein Y; The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Friedman N; The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Beharier O; Hadassah Medical Center and The Hebrew University of Jerusalem, Jerusalem, Israel.
Demma JA; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Zamir G; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Hubert A; Oncology Department, Hadassah Medical Center, Jerusalem, Israel.
Benny O; The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2023 Nov 13; Vol. 6 (1), pp. 1157. Date of Electronic Publication: 2023 Nov 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Precision Medicine*
Neoplasms*/drug therapy
Neoplasms*/pathology
Humans ; Drug Evaluation, Preclinical ; Printing, Three-Dimensional ; Lab-On-A-Chip Devices ; Tumor Microenvironment

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na półce

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Skocz do pozycji: 20.

Tytuł:: Three Distinct Reporter Systems of Hepatitis E Virus and Their Utility as Drug Screening Platforms.
Autorzy:: Primadharsini PP; Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke 329-0498, Tochigi, Japan.
Nagashima S; Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke 329-0498, Tochigi, Japan.
Nishiyama T; Laboratory of Membrane Proteins, Research Division for Quantitative Life Sciences, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Okamoto H; Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke 329-0498, Tochigi, Japan.; Pokaż więcej
Źródło:: Viruses [Viruses] 2023 Sep 23; Vol. 15 (10). Date of Electronic Publication: 2023 Sep 23.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Hepatitis E virus*
Hepatitis E*/drug therapy
Humans ; Drug Evaluation, Preclinical ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Ribavirin/therapeutic use ; Virus Replication

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