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Wyszukujesz frazę ""Drug Evaluation, Preclinical"" wg kryterium: Temat


Tytuł :
Lack of efficacy of mono-mode of action therapeutics in COVID-19 therapy - How the lack of predictive power of preclinical cell and animal studies leads developments astray.
Autorzy :
Haberland A; Berlin Cures GmbH, Berlin, Germany.
Müller J; Berlin Cures GmbH, Berlin, Germany.
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Źródło :
Chemical biology & drug design [Chem Biol Drug Des] 2022 Jan; Vol. 99 (1), pp. 32-45. Date of Electronic Publication: 2021 Oct 31.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*/methods
Drug Evaluation, Preclinical*/methods
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/pharmacology ; Disease Models, Animal ; Humans
Czasopismo naukowe
Tytuł :
Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition.
Autorzy :
Faisal S; Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan.
Badshah SL; Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan.
Kubra B; Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan.
Sharaf M; Department of Biochemistry and Molecular Biology, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China.; Department of Biochemistry, Faculty of Agriculture, AL-Azhar University, Nasr City, Cairo 11751, Egypt.
Emwas AH; Core Labs, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Jaremko M; Smart-Health Initiative (SHI) and Red Sea Research Center (RSRC), Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Abdalla M; Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan 250012, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Dec 30; Vol. 27 (1). Date of Electronic Publication: 2021 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Computational Biology/*methods
Coronavirus RNA-Dependent RNA Polymerase/*antagonists & inhibitors
Flavonoids/*pharmacology
SARS-CoV-2/*enzymology
Allosteric Site ; COVID-19/virology ; Catalytic Domain ; Drug Design ; Humans ; Intestinal Absorption ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł :
Virtual Screening in Search for a Chemical Probe for Angiotensin-Converting Enzyme 2 (ACE2).
Autorzy :
Kravets IO; Institute of High Technologies, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Street, 01033 Kyiv, Ukraine.; Chemspace LLC, 85 Chervonotkatska Street, Suite 1, 02094 Kyiv, Ukraine.
Dudenko DV; Enamine Ltd., 78 Chervonotkatska Street, 02660 Kyiv, Ukraine.
Pashenko AE; Institute of High Technologies, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Street, 01033 Kyiv, Ukraine.; Enamine Ltd., 78 Chervonotkatska Street, 02660 Kyiv, Ukraine.; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska Street 5, 03028 Kyiv, Ukraine.
Borisova TA; Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Leontovycha St. 9, 02000 Kyiv, Ukraine.
Tolstanova GM; Institute of High Technologies, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Street, 01033 Kyiv, Ukraine.
Ryabukhin SV; Institute of High Technologies, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Street, 01033 Kyiv, Ukraine.; Enamine Ltd., 78 Chervonotkatska Street, 02660 Kyiv, Ukraine.; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska Street 5, 03028 Kyiv, Ukraine.
Volochnyuk DM; Institute of High Technologies, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Street, 01033 Kyiv, Ukraine.; Enamine Ltd., 78 Chervonotkatska Street, 02660 Kyiv, Ukraine.; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska Street 5, 03028 Kyiv, Ukraine.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Dec 14; Vol. 26 (24). Date of Electronic Publication: 2021 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Drug Evaluation, Preclinical*
Angiotensin-Converting Enzyme 2/*antagonists & inhibitors
COVID-19/*drug therapy
COVID-19/prevention & control ; Computer Simulation ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; SARS-CoV-2/growth & development
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Organizational Update: The NINDS-Sponsored Stroke Preclinical Assessment Network Is Moving to Its Next Stage.
Autorzy :
Bosetti F; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Koenig JI; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Janis LS; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Wright CB; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
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Źródło :
Stroke [Stroke] 2021 Dec; Vol. 52 (12), pp. e842-e843. Date of Electronic Publication: 2021 Nov 22.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Drug Evaluation, Preclinical*
Stroke*
Neuroprotective Agents/*pharmacology
Animals ; Female ; Male ; National Institute of Neurological Disorders and Stroke (U.S.) ; United States
Czasopismo naukowe
Tytuł :
Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease.
Autorzy :
Marconi GD; Orofacial Development and Regeneration, Institute of Oral Biology, University of Zurich, 8032 Zurich, Switzerland.; Department of Medical, Oral and Biotechnological Sciences, University 'G. d'Annunzio' Chieti-Pescara, 66100 Chieti, Italy.
Porcheri C; Orofacial Development and Regeneration, Institute of Oral Biology, University of Zurich, 8032 Zurich, Switzerland.
Trubiani O; Department of Medical, Oral and Biotechnological Sciences, University 'G. d'Annunzio' Chieti-Pescara, 66100 Chieti, Italy.
Mitsiadis TA; Orofacial Development and Regeneration, Institute of Oral Biology, University of Zurich, 8032 Zurich, Switzerland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 19; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Evaluation, Preclinical*
Cell Culture Techniques/*methods
Receptors, Notch/*genetics
Humans ; Microfluidics/methods ; Organoids/cytology ; Signal Transduction/genetics ; Spheroids, Cellular/cytology
Czasopismo naukowe
Tytuł :
Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.
Autorzy :
Kessie DK; Chair of Microbiology, Biocenter of the University of Würzburg, Würzburg, Germany.
Rudel T; Chair of Microbiology, Biocenter of the University of Würzburg, Würzburg, Germany.
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Źródło :
PLoS biology [PLoS Biol] 2021 Nov 12; Vol. 19 (11), pp. e3001462. Date of Electronic Publication: 2021 Nov 12 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*
Models, Biological*
Mucous Membrane/*immunology
Vaccines/*immunology
Bioreactors ; Host-Pathogen Interactions/immunology ; Humans ; Immunity ; Perfusion
Czasopismo naukowe
Tytuł :
A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening.
Autorzy :
Park Y; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jung JG; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yu ZC; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Asaka R; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shen W; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wang Y; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jung WH; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Tomaszewski A; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shimberg G; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chen Y; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Parimi V; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gaillard S; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shih IM; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
Wang TL; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
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Źródło :
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2021 Nov; Vol. 101 (11), pp. 1505-1512. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Line*
Drug Evaluation, Preclinical*
Epithelial Cells*
Endometrium/*cytology
Animals ; Female ; Humans ; Mice ; Receptors, Estrogen/metabolism
Czasopismo naukowe
Tytuł :
Toward Better Reproducibility in Experimental Research on New Agents for Pulmonary Hypertension. An Analysis of Data from Four Hundred Animal Studies.
Autorzy :
Jasińska-Stroschein M; Department of Biopharmacy, Medical University of Łódź, ul. Muszyńskiego 1, 90-151, Lodz, Poland. .
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Źródło :
Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2021 Aug; Vol. 35 (4), pp. 707-718. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Drug Evaluation, Preclinical*/methods
Drug Evaluation, Preclinical*/standards
Drug Development/*methods
Hypertension, Pulmonary/*drug therapy
Animals ; Bias ; Disease Models, Animal ; Humans ; Reproducibility of Results ; Research Design/standards ; Translational Research, Biomedical
Czasopismo naukowe
Tytuł :
Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay.
Autorzy :
Svensen N; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Wyllie S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Gray DW; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
De Rycker M; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Oct 11; Vol. 15 (10), pp. e0009870. Date of Electronic Publication: 2021 Oct 11 (Print Publication: 2021).
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Automation/*methods
Chagas Disease/*parasitology
Drug Evaluation, Preclinical/*methods
Microscopy, Fluorescence/*methods
Trypanocidal Agents/*pharmacology
Trypanosoma cruzi/*drug effects
Automation/instrumentation ; Drug Evaluation, Preclinical/instrumentation ; Humans ; Microscopy, Fluorescence/instrumentation ; Trypanosoma cruzi/genetics ; Trypanosoma cruzi/physiology
Czasopismo naukowe
Tytuł :
Laboratory evaluation of twelve portable devices for medicine quality screening.
Autorzy :
Zambrzycki SC; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America.
Caillet C; Lao-Oxford-Mahosot Hospital-Wellcome Trust-Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom.; Infectious Diseases Data Observatory (IDDO) & WorldWide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford, United Kingdom.
Vickers S; Lao-Oxford-Mahosot Hospital-Wellcome Trust-Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom.; Infectious Diseases Data Observatory (IDDO) & WorldWide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford, United Kingdom.
Bouza M; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America.
Donndelinger DV; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America.
Geben LC; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America.
Bernier MC; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America.
Newton PN; Lao-Oxford-Mahosot Hospital-Wellcome Trust-Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom.; Infectious Diseases Data Observatory (IDDO) & WorldWide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford, United Kingdom.
Fernández FM; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Sep 30; Vol. 15 (9), pp. e0009360. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemistry Techniques, Analytical/*instrumentation
Chemistry Techniques, Analytical/*methods
Counterfeit Drugs/*analysis
Drug Evaluation, Preclinical/*instrumentation
Substandard Drugs/*analysis
Drug Evaluation, Preclinical/methods ; Lab-On-A-Chip Devices ; Quality Control ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Multiphase evaluation of portable medicines quality screening devices.
Autorzy :
Caillet C; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Infectious Diseases Data Observatory (IDDO)/World Wide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford, United Kingdom.; Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Vickers S; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Infectious Diseases Data Observatory (IDDO)/World Wide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford, United Kingdom.
Zambrzycki S; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America.
Luangasanatip N; Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Vidhamaly V; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Infectious Diseases Data Observatory (IDDO)/World Wide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford, United Kingdom.
Boutsamay K; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Infectious Diseases Data Observatory (IDDO)/World Wide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford, United Kingdom.
Boupha P; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Infectious Diseases Data Observatory (IDDO)/World Wide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford, United Kingdom.
Lubell Y; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Fernández FM; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America.
Newton PN; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Infectious Diseases Data Observatory (IDDO)/World Wide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford, United Kingdom.; Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Sep 30; Vol. 15 (9), pp. e0009287. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021).
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemistry Techniques, Analytical/*instrumentation
Chemistry Techniques, Analytical/*methods
Counterfeit Drugs/*analysis
Drug Evaluation, Preclinical/*methods
Substandard Drugs/*analysis
Drug Evaluation, Preclinical/instrumentation ; Humans ; Quality Control
Raport
Tytuł :
Establishment of a Drug Screening Model for Cardiac Complications of Acute Renal Failure.
Autorzy :
Liao S; Chongqing Clinical Research Center of Kidney and Urology Diseases, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Department of Nephrology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.
Yang W; Chongqing Clinical Research Center of Kidney and Urology Diseases, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Department of Nephrology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.
Yu T; Department of Respiratory Medicine, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.
Dai L; Chongqing Clinical Research Center of Kidney and Urology Diseases, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Department of Nephrology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.
Liu X; Chongqing Clinical Research Center of Kidney and Urology Diseases, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Department of Nephrology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.
Zhang J; Chongqing Clinical Research Center of Kidney and Urology Diseases, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Department of Nephrology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.
Zhao J; Chongqing Clinical Research Center of Kidney and Urology Diseases, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Department of Nephrology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.
Liu C; Chongqing Clinical Research Center of Kidney and Urology Diseases, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Department of Nephrology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.
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Źródło :
Biomolecules [Biomolecules] 2021 Sep 16; Vol. 11 (9). Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*
Acute Kidney Injury/*complications
Cardiovascular Diseases/*drug therapy
Cardiovascular Diseases/*etiology
Acute Kidney Injury/pathology ; Acute Kidney Injury/physiopathology ; Animals ; Animals, Genetically Modified ; Cardio-Renal Syndrome/drug therapy ; Cardio-Renal Syndrome/etiology ; Cardiovascular Diseases/pathology ; Digoxin/pharmacology ; Digoxin/therapeutic use ; Disease Models, Animal ; Enalapril/pharmacology ; Enalapril/therapeutic use ; Epithelial Cells/pathology ; Humans ; Kidney Tubules/pathology ; Kidney Tubules/physiopathology ; Larva/physiology ; Metronidazole ; Regional Blood Flow/drug effects ; Thioctic Acid/pharmacology ; Thioctic Acid/therapeutic use ; Treatment Outcome ; Zebrafish
Czasopismo naukowe
Tytuł :
Induced Pluripotent Stem Cells (iPSCs)-Roles in Regenerative Therapies, Disease Modelling and Drug Screening.
Autorzy :
Aboul-Soud MAM; Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
Alzahrani AJ; Department of Clinical Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia.
Mahmoud A; Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
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Źródło :
Cells [Cells] 2021 Sep 05; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Evaluation, Preclinical*
Regenerative Medicine*
Stem Cell Transplantation*
Translational Research, Biomedical*
Cell Differentiation/*drug effects
Cell Proliferation/*drug effects
Induced Pluripotent Stem Cells/*drug effects
Induced Pluripotent Stem Cells/*transplantation
Regeneration/*drug effects
Animals ; Cell Line ; Gene Expression Regulation, Developmental ; High-Throughput Screening Assays ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Phenotype ; Signal Transduction
Czasopismo naukowe
Tytuł :
Screening strategies for identifying RNA- and ribonucleoprotein-targeted compounds.
Autorzy :
Martin WJ; Cellzome GmbH, Functional Genomics R&D, GlaxoSmithKline, 69117 Heidelberg, Germany; European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Grandi P; Cellzome GmbH, Functional Genomics R&D, GlaxoSmithKline, 69117 Heidelberg, Germany.
Marcia M; European Molecular Biology Laboratory (EMBL) Grenoble, 71 Avenue des Martyrs, Grenoble 38042, France. Electronic address: .
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Źródło :
Trends in pharmacological sciences [Trends Pharmacol Sci] 2021 Sep; Vol. 42 (9), pp. 758-771. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Evaluation, Preclinical*
RNA*
Ribonucleoproteins*
High-Throughput Screening Assays ; Humans ; Ligands ; Small Molecule Libraries
Czasopismo naukowe
Tytuł :
High-content approaches to anthelmintic drug screening.
Autorzy :
Zamanian M; Department of Pathobiological Sciences, University of Wisconsin -, Madison, WI, USA. Electronic address: .
Chan JD; Department of Pathobiological Sciences, University of Wisconsin -, Madison, WI, USA; Department of Chemistry, University of Wisconsin -, Oshkosh, WI, USA. Electronic address: .
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Źródło :
Trends in parasitology [Trends Parasitol] 2021 Sep; Vol. 37 (9), pp. 780-789. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Anthelmintics*/pharmacology
Drug Evaluation, Preclinical*
Animals ; Helminthiasis/drug therapy ; Helminths/drug effects ; Host-Parasite Interactions
Czasopismo naukowe
Tytuł :
Screening for inhibitory effects of crude drugs on furin-like enzymatic activities.
Autorzy :
Kiba Y; Laboratory of Pharmacognocy, School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1, Keyakidai, Sakado, Saitama, 350-0295, Japan.
Oyama R; Laboratory of Natural Products and Phytochemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1, Keyakidai, Sakado, Saitama, 350-0295, Japan.
Misawa S; Laboratory of Natural Products and Phytochemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1, Keyakidai, Sakado, Saitama, 350-0295, Japan.
Tanikawa T; Laboratory of Nutri-Pharmacotherapeutics Management, School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1, Keyakidai, Sakado, Saitama, 350-0295, Japan.
Kitamura M; Laboratory of Pharmacognocy, School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1, Keyakidai, Sakado, Saitama, 350-0295, Japan. .
Suzuki R; Laboratory of Natural Products and Phytochemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1, Keyakidai, Sakado, Saitama, 350-0295, Japan. .
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Źródło :
Journal of natural medicines [J Nat Med] 2021 Sep; Vol. 75 (4), pp. 1080-1085. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Letter
MeSH Terms :
Drug Evaluation, Preclinical*
Enzyme Assays*
Cnidium/*chemistry
Furin/*antagonists & inhibitors
Furin/*metabolism
Plant Extracts/*pharmacology
A549 Cells ; COVID-19/drug therapy ; COVID-19/virology ; Humans ; Inhibitory Concentration 50 ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/metabolism
Opinia redakcyjna
Tytuł :
Construction of a Noninfectious SARS-CoV-2 Replicon for Antiviral-Drug Testing and Gene Function Studies.
Autorzy :
Nguyen HT; Vaccine and Infectious Disease Organization, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.
Falzarano D; Vaccine and Infectious Disease Organization, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.
Gerdts V; Vaccine and Infectious Disease Organization, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.
Liu Q; Vaccine and Infectious Disease Organization, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.; Vaccinology and Immunotherapeutics, School of Public Health, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewangrid.25152.31, Saskatoon, Saskatchewan, Canada.
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Źródło :
Journal of virology [J Virol] 2021 Aug 25; Vol. 95 (18), pp. e0068721. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*
Replicon*
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Green Fluorescent Proteins/*metabolism
SARS-CoV-2/*drug effects
Virus Replication/*drug effects
Animals ; COVID-19/virology ; Chlorocebus aethiops ; Green Fluorescent Proteins/genetics ; HEK293 Cells ; High-Throughput Screening Assays ; Humans
Czasopismo naukowe
Tytuł :
A computational study of cooperative binding to multiple SARS-CoV-2 proteins.
Autorzy :
Li J; Department of Chemistry, University of Vermont, Burlington, VT, 05405, USA. .
McKay KT; Department of Chemistry, University of Vermont, Burlington, VT, 05405, USA.
Remington JM; Department of Chemistry, University of Vermont, Burlington, VT, 05405, USA.
Schneebeli ST; Department of Chemistry, University of Vermont, Burlington, VT, 05405, USA.
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Źródło :
Scientific reports [Sci Rep] 2021 Aug 11; Vol. 11 (1), pp. 16307. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Drug Evaluation, Preclinical*
Medicine, Chinese Traditional*
Antiviral Agents/*pharmacology
Drugs, Chinese Herbal/*pharmacology
SARS-CoV-2/*drug effects
Viral Proteins/*metabolism
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Cats ; Computational Biology ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/metabolism ; Flavonoids/metabolism ; Humans ; Molecular Dynamics Simulation ; Protein Binding ; RNA-Dependent RNA Polymerase/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Development of A MERS-CoV Replicon Cell Line for Antiviral Screening.
Autorzy :
Chen J; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Hu BJ; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhao K; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Luo Y; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Lin HF; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Shi ZL; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China. .
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Źródło :
Virologica Sinica [Virol Sin] 2021 Aug; Vol. 36 (4), pp. 730-735. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents*/pharmacology
Cell Line*
Drug Evaluation, Preclinical*
Middle East Respiratory Syndrome Coronavirus*/genetics
Coronavirus Infections/drug therapy ; Humans ; Lopinavir/therapeutic use ; Replicon
Czasopismo naukowe

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