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Tytuł:
Anesthetized guinea pig as a model for drug testing.
Autorzy:
Bartakova A; Department of Physiology, Faculty of Medicine, Masaryk University, Czech Republic. .
Novakova M
Stracina T
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Źródło:
Physiological research [Physiol Res] 2022 Dec 31; Vol. 71 (S2), pp. S211-S218.
Typ publikacji:
Journal Article
MeSH Terms:
Cardiovascular System*/drug effects
Electrocardiography*
Myocardial Contraction*/drug effects
Myocardial Contraction*/physiology
Drug Evaluation, Preclinical*
Animals ; Guinea Pigs ; Humans ; Heart/drug effects ; Heart/physiology ; Heart Rate ; Blood Pressure/drug effects ; Disease Models, Animal
Czasopismo naukowe
Szczegóły
Tytuł:
Development of non-bias phenotypic drug screening for cardiomyocyte hypertrophy by image segmentation using deep learning.
Autorzy:
Komuro J; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: sieg_.
Tokuoka Y; Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama-shi, Kanagawa, 223-8522, Japan. Electronic address: .
Seki T; Department of Healthcare Information Management, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. Electronic address: .
Kusumoto D; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Hashimoto H; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Katsuki T; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; Department of Cardiology, Saitama Municipal Hospital, 2460 Mimuro, Midori-ku, Saitama-shi, Saitama, Japan. Electronic address: .
Nakamura T; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Akiba Y; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Kuoka T; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Kimura M; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Yamada T; Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama-shi, Kanagawa, 223-8522, Japan. Electronic address: .
Fukuda K; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Funahashi A; Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama-shi, Kanagawa, 223-8522, Japan. Electronic address: .
Yuasa S; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Dec 03; Vol. 632, pp. 181-188. Date of Electronic Publication: 2022 Oct 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cardiomegaly*/diagnostic imaging
Cardiomegaly*/drug therapy
Deep Learning*
Drug Evaluation, Preclinical*/methods
Heart Failure*/drug therapy
Animals ; Mice ; Rats ; Angiotensin II/pharmacology ; Cells, Cultured ; Cholesterol ; Endothelin-1 ; Ezetimibe ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/drug effects
Czasopismo naukowe
Szczegóły
Tytuł:
A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasis.
Autorzy:
Sahu N
Grandi FC
Bhutani N
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Źródło:
JCI insight [JCI Insight] 2022 Oct 04; Vol. 7 (20). Date of Electronic Publication: 2022 Oct 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cartilage*/drug effects
Cartilage*/metabolism
Drug Evaluation, Preclinical*/methods
Osteoarthritis*/drug therapy
Osteoarthritis*/metabolism
Humans ; Homeostasis/drug effects ; NF-kappa B/metabolism ; Signal Transduction ; Single-Cell Analysis/instrumentation ; Single-Cell Analysis/methods
Czasopismo naukowe
Szczegóły
Tytuł:
Organoid and microfluidics-based platforms for drug screening in COVID-19.
Autorzy:
Ramezankhani R; Department of Applied Cell Sciences, Faculty of Basic Science and Advanced Medical Technologies, Royan Institute, ACECR, Tehran, Iran; Department of Development and Regeneration, Stem Cell Biology and Embryology, KU Leuven Stem Cell Institute, Leuven, Belgium; Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, ACECR, Tehran, Iran.
Solhi R; Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, ACECR, Tehran, Iran; Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Chai YC; Department of Development and Regeneration, Stem Cell Biology and Embryology, KU Leuven Stem Cell Institute, Leuven, Belgium.
Vosough M; Department of Applied Cell Sciences, Faculty of Basic Science and Advanced Medical Technologies, Royan Institute, ACECR, Tehran, Iran; Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, ACECR, Tehran, Iran. Electronic address: .
Verfaillie C; Department of Development and Regeneration, Stem Cell Biology and Embryology, KU Leuven Stem Cell Institute, Leuven, Belgium. Electronic address: .
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Źródło:
Drug discovery today [Drug Discov Today] 2022 Apr; Vol. 27 (4), pp. 1062-1076. Date of Electronic Publication: 2021 Dec 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Drug Evaluation, Preclinical*
Microfluidics*
Models, Biological*
Organoids*
SARS-CoV-2*
COVID-19 Drug Treatment*
Animals ; COVID-19/genetics ; Gene Editing ; Genome ; Humans ; Tissue Engineering
Czasopismo naukowe
Szczegóły
Tytuł:
Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2.
Autorzy:
Schultz DC; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA. .
Johnson RM; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Ayyanathan K; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Miller J; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Whig K; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Kamalia B; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Dittmar M; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Weston S; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Hammond HL; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Dillen C; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Ardanuy J; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Taylor L; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Lee JS; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Li M; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lee E; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Shoffler C; Metabolomics Core, Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
Petucci C; Metabolomics Core, Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
Constant S; Epithelix, Geneva, Switzerland.
Ferrer M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Thaiss CA; Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA.
Frieman MB; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA. .
Cherry S; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA. .; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA. .; Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło:
Nature [Nature] 2022 Apr; Vol. 604 (7904), pp. 134-140. Date of Electronic Publication: 2022 Feb 07.
Typ publikacji:
Journal Article
MeSH Terms:
Antiviral Agents*/pharmacology
Drug Evaluation, Preclinical*
Nucleosides*/analogs & derivatives
Nucleosides*/pharmacology
Pyrimidines*/pharmacology
SARS-CoV-2*/drug effects
Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; COVID-19/virology ; Cell Line ; Cytidine/analogs & derivatives ; Humans ; Hydroxylamines ; COVID-19 Drug Treatment
Czasopismo naukowe
Szczegóły
Tytuł:
Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification.
Autorzy:
Baddock HT; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Brolih S; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Yosaatmadja Y; Centre for Medicines Discovery, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.
Ratnaweera M; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Bielinski M; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
Swift LP; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Cruz-Migoni A; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Fan H; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Keown JR; Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford OX3 7BN, UK.
Walker AP; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Morris GM; Department of Statistics, University of Oxford, 24-29 St Giles', Oxford OX1 3LB, UK.
Grimes JM; Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford OX3 7BN, UK.; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Fodor E; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
Gileadi O; Centre for Medicines Discovery, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.
McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2022 Feb 22; Vol. 50 (3), pp. 1484-1500.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Evaluation, Preclinical*
Genomic Instability*/drug effects
Genomic Instability*/genetics
Antiviral Agents/*pharmacology
Exoribonucleases/*metabolism
Genome, Viral/*genetics
SARS-CoV-2/*enzymology
SARS-CoV-2/*genetics
Viral Nonstructural Proteins/*metabolism
Viral Regulatory and Accessory Proteins/*metabolism
Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Exoribonucleases/antagonists & inhibitors ; Genome, Viral/drug effects ; HIV Integrase Inhibitors/pharmacology ; Isoindoles/pharmacology ; Multienzyme Complexes/antagonists & inhibitors ; Multienzyme Complexes/metabolism ; Organoselenium Compounds/pharmacology ; RNA, Viral/biosynthesis ; RNA, Viral/genetics ; Raltegravir Potassium/pharmacology ; SARS-CoV-2/drug effects ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Regulatory and Accessory Proteins/antagonists & inhibitors ; Virus Replication/drug effects ; Virus Replication/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma.
Autorzy:
Lim W; Erasmus MC, University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, The Netherlands.
Nyuykonge B; Erasmus MC, University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, The Netherlands.
Eadie K; Erasmus MC, University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, The Netherlands.
Konings M; Erasmus MC, University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, The Netherlands.
Smeets J; Erasmus MC, University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, The Netherlands.
Fahal A; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.
Bonifaz A; Hospital General de Mexico Dr Eduardo Liceaga, Mexico City, Mexico.
Todd M; University College London, School of Pharmacy, London, United Kingdom.
Perry B; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
Samby K; Medicines for Malaria Venture (MMV), Geneva, Switzerland.
Burrows J; Medicines for Malaria Venture (MMV), Geneva, Switzerland.
Verbon A; Erasmus MC, University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, The Netherlands.
van de Sande W; Erasmus MC, University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, The Netherlands.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Feb 04; Vol. 16 (2), pp. e0010159. Date of Electronic Publication: 2022 Feb 04 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Evaluation, Preclinical*
Antifungal Agents/*pharmacology
Mycetoma/*drug therapy
Acetamides/pharmacology ; Animals ; Ascomycota/drug effects ; Drug Discovery ; Fenbendazole/pharmacology ; Madurella/drug effects ; Moths/microbiology ; Neglected Diseases ; Piperazines/pharmacology ; Pyrimidines/pharmacology ; Pyrroles/pharmacology ; Thiazoles/pharmacology ; Triazoles/pharmacology
SCR Organism:
Falciformispora senegalensis; Medicopsis romeroi
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of in vitro angiotensin-converting enzyme and dipeptidyl peptidase IV inhibitory peptides from draft beer by virtual screening and molecular docking.
Autorzy:
Wenhui T; State Key Laboratory of Biological Fermentation Engineering of Beer, Tsingtao Brewery Co. Ltd. Qingdao, Qingdao, China.; Faculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, China.
Shumin H; State Key Laboratory of Biological Fermentation Engineering of Beer, Tsingtao Brewery Co. Ltd. Qingdao, Qingdao, China.
Yongliang Z; Faculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, China.
Liping S; Faculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, China.
Hua Y; State Key Laboratory of Biological Fermentation Engineering of Beer, Tsingtao Brewery Co. Ltd. Qingdao, Qingdao, China.
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Źródło:
Journal of the science of food and agriculture [J Sci Food Agric] 2022 Feb; Vol. 102 (3), pp. 1085-1094. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji:
Evaluation Study; Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme Inhibitors/*chemistry
Beer/*analysis
Dipeptidyl Peptidase 4/*chemistry
Dipeptidyl-Peptidase IV Inhibitors/*chemistry
Drug Evaluation, Preclinical/*methods
Peptides/*chemistry
Peptidyl-Dipeptidase A/*chemistry
Chromatography, High Pressure Liquid ; Drug Evaluation, Preclinical/instrumentation ; Humans ; Hypoglycemic Agents/chemistry ; Mass Spectrometry ; Molecular Docking Simulation
Czasopismo naukowe
Szczegóły
Tytuł:
Can preclinical drug development help to predict adverse events in clinical trials?
Autorzy:
Chi LH; Translational Breast Cancer Program, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia.
Burrows AD; Translational Breast Cancer Program, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia.
Anderson RL; Translational Breast Cancer Program, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: .
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Źródło:
Drug discovery today [Drug Discov Today] 2022 Jan; Vol. 27 (1), pp. 257-268. Date of Electronic Publication: 2021 Aug 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Drug Evaluation, Preclinical*/methods
Drug Evaluation, Preclinical*/trends
Drugs, Investigational*/pharmacology
Drugs, Investigational*/toxicity
Drug Development/*methods
Animals ; High-Throughput Screening Assays/methods ; Humans ; Technology, Pharmaceutical/methods ; Technology, Pharmaceutical/trends
Czasopismo naukowe
Szczegóły
Tytuł:
Organoids in modelling infectious diseases.
Autorzy:
Shpichka A; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, Moscow, Russia; Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia; Chemistry Department, Lomonosov Moscow State University, Moscow, Russia. Electronic address: .
Bikmulina P; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, Moscow, Russia.
Peshkova M; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, Moscow, Russia; Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.
Heydari Z; Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.
Kosheleva N; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, Moscow, Russia; Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia; FSBSI 'Institute of General Pathology and Pathophysiology', Moscow, Russia.
Vosough M; Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran. Electronic address: .
Timashev P; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, Moscow, Russia; Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia; Chemistry Department, Lomonosov Moscow State University, Moscow, Russia; Department of Polymers and Composites, NN Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia. Electronic address: timashev_p_.
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Źródło:
Drug discovery today [Drug Discov Today] 2022 Jan; Vol. 27 (1), pp. 223-233. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Drug Evaluation, Preclinical*/methods
Drug Evaluation, Preclinical*/trends
Infections*/drug therapy
Infections*/microbiology
Organoids*/drug effects
Organoids*/microbiology
Animals ; Cells, Cultured ; Models, Animal ; Reproducibility of Results
Czasopismo naukowe
Szczegóły
Tytuł:
An integrated biomimetic array chip for establishment of collagen-based 3D primary human hepatocyte model for prediction of clinical drug-induced liver injury.
Autorzy:
Xiao RR; R&D Department, Beijing Daxiang Biotech, Beijing, China.
Lv T; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Tu X; Discovery Biology Unit, WuXi AppTec (Shanghai) Co., Ltd., Shanghai, China.
Li P; R&D Department, Beijing Daxiang Biotech, Beijing, China.
Wang T; Discovery Biology Unit, WuXi AppTec (Shanghai) Co., Ltd., Shanghai, China.
Dong H; Discovery Biology Unit, WuXi AppTec (Shanghai) Co., Ltd., Shanghai, China.
Tu P; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Ai X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
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Źródło:
Biotechnology and bioengineering [Biotechnol Bioeng] 2021 Dec; Vol. 118 (12), pp. 4687-4698. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Evaluation, Preclinical*/instrumentation
Drug Evaluation, Preclinical*/methods
Hepatocytes*/cytology
Hepatocytes*/drug effects
Lab-On-A-Chip Devices*
Models, Biological*
Chemical and Drug Induced Liver Injury/*metabolism
Biomimetics ; Cells, Cultured ; Humans ; Spheroids, Cellular/cytology ; Spheroids, Cellular/drug effects
Czasopismo naukowe
Szczegóły
Tytuł:
Heart-on-a-chip platforms and biosensor integration for disease modeling and phenotypic drug screening.
Autorzy:
Criscione J; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Rezaei Z; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA, USA.
Hernandez Cantu CM; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA, USA.
Murphy S; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Shin SR; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA, USA. Electronic address: .
Kim DH; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: .
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Źródło:
Biosensors & bioelectronics [Biosens Bioelectron] 2023 Jan 15; Vol. 220, pp. 114840. Date of Electronic Publication: 2022 Oct 25.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Biosensing Techniques*
Induced Pluripotent Stem Cells*
Heart Diseases*/diagnosis
Heart Diseases*/drug therapy
Animals ; Humans ; Drug Evaluation, Preclinical ; Lab-On-A-Chip Devices ; Myocytes, Cardiac
Czasopismo naukowe
Szczegóły
Tytuł:
A drug screening to identify novel combinatorial strategies for boosting cancer immunotherapy efficacy.
Autorzy:
Zhang Z; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Wang G; Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Zhong K; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Chen Y; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Yang N; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Lu Q; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Yuan B; Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Wang Z; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Li H; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Guo L; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Zhang R; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Wu Z; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Zheng M; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Zhao S; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Tang X; Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Shao B; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China. .; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. .
Tong A; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Jan 13; Vol. 21 (1), pp. 23. Date of Electronic Publication: 2023 Jan 13.
Typ publikacji:
Journal Article
MeSH Terms:
Hedgehog Proteins*
Neoplasms*/therapy
Humans ; Animals ; Mice ; Drug Evaluation, Preclinical ; Early Detection of Cancer ; Immunotherapy ; Cytokines ; Immunotherapy, Adoptive/methods ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Use of mouse primary epidermal organoids for USA300 infection modeling and drug screening.
Autorzy:
Xie X; School of Pharmacy, Fudan University, Shanghai, China.; Shanghai Drugability Biomass Product Evaluation Professional Public Service Platform, Center for Pharmacological Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai, China.
Tong X; Shanghai Children's Medical Center affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li Z; Shanghai Drugability Biomass Product Evaluation Professional Public Service Platform, Center for Pharmacological Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai, China.
Cheng Q; Shanghai Drugability Biomass Product Evaluation Professional Public Service Platform, Center for Pharmacological Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai, China.
Wang X; Shanghai Drugability Biomass Product Evaluation Professional Public Service Platform, Center for Pharmacological Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai, China.
Long Y; Department of Traditional Chinese Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Liu F; Shanghai Drugability Biomass Product Evaluation Professional Public Service Platform, Center for Pharmacological Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai, China.
Wang Y; School of Pharmacy, Fudan University, Shanghai, China. .
Wang J; Shanghai Drugability Biomass Product Evaluation Professional Public Service Platform, Center for Pharmacological Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai, China. .
Liu L; Shanghai Drugability Biomass Product Evaluation Professional Public Service Platform, Center for Pharmacological Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai, China. .
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Źródło:
Cell death & disease [Cell Death Dis] 2023 Jan 11; Vol. 14 (1), pp. 15. Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Methicillin-Resistant Staphylococcus aureus*
Staphylococcal Infections*/drug therapy
Staphylococcal Infections*/microbiology
Mice ; Animals ; Drug Evaluation, Preclinical ; Proteomics ; Epidermis
Czasopismo naukowe
Szczegóły
Tytuł:
Replacing mammals in drug development: Non-mammalian models accelerate translational and pre-clinical research: Non-mammalian models accelerate translational and pre-clinical research.
Autorzy:
Hunter P; Freelance Journalist in London, London, UK.
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Źródło:
EMBO reports [EMBO Rep] 2023 Jan 09; Vol. 24 (1), pp. e56485. Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:
Journal Article
MeSH Terms:
Mammals*
Animals ; Models, Animal ; Disease Models, Animal ; Drug Evaluation, Preclinical
Czasopismo naukowe
Szczegóły
Tytuł:
Human induced pluripotent stem cell (hiPSC)-derived cardiomyocyte modelling of cardiovascular diseases for natural compound discovery.
Autorzy:
Zhu K; Zhejiang Key Laboratory of Pathophysiology, School of Public Health, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
Bao X; Department of Cardiology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, PR China; Department of Global Health, Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, Zhejiang, PR China.
Wang Y; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, Zhejiang, PR China.
Lu T; Clinical Research Center of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China. Electronic address: .
Zhang L; College of Life Science, Zhejiang Chinese Medical University, Hangzhou, PR China. Electronic address: .
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Źródło:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Jan; Vol. 157, pp. 113970. Date of Electronic Publication: 2022 Nov 10.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Induced Pluripotent Stem Cells*/metabolism
Cardiovascular Diseases*/drug therapy
Cardiovascular Diseases*/metabolism
Cardiomyopathies*/metabolism
Biological Products*/pharmacology
Biological Products*/metabolism
Animals ; Humans ; Drug Evaluation, Preclinical/methods ; Myocytes, Cardiac ; Cell Differentiation
Czasopismo naukowe
Szczegóły
Tytuł:
iPSC-based model of Vogt-Koyanagi-Harada disease for phenotype recapitulation and drug screening.
Autorzy:
Li W; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Tan J; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
He S; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Yue Y; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Liu H; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Li R; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Wang X; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Wang G; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Fan W; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Zhao C; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Zhou Q; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Yang P; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.. Electronic address: .
Hou S; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Ophthalmology, Chongqing, China; Chongqing Eye Institute, Chongqing, China; Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.. Electronic address: .
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Źródło:
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2023 Jan; Vol. 246, pp. 109205. Date of Electronic Publication: 2022 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
Uveomeningoencephalitic Syndrome*/drug therapy
Induced Pluripotent Stem Cells*
Humans ; Drug Evaluation, Preclinical ; Leukocytes, Mononuclear ; Retinal Pigment Epithelium
Czasopismo naukowe
Szczegóły
Tytuł:
Emerging platforms for high-throughput enzymatic bioassays.
Autorzy:
Shao F; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Lee PW; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Li H; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Hsieh K; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Wang TH; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA. Electronic address: .
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Źródło:
Trends in biotechnology [Trends Biotechnol] 2023 Jan; Vol. 41 (1), pp. 120-133. Date of Electronic Publication: 2022 Jul 18.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Microfluidics*/methods
Microfluidic Analytical Techniques*/methods
High-Throughput Screening Assays/methods ; Drug Evaluation, Preclinical ; Biological Assay
Czasopismo naukowe
Szczegóły
Tytuł:
Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds.
Autorzy:
Bufalo MC; Laboratory of Pain and Signaling, Butantan Institute, São Paulo 05503-900, Brazil.; Center of Excellence in New Target Discovery, Butantan Institute, São Paulo 05503-900, Brazil.
Almeida MES; Center of Excellence in New Target Discovery, Butantan Institute, São Paulo 05503-900, Brazil.; Laboratory of Pathophysiology, Butantan Institute, São Paulo 05503-900, Brazil.
Jensen JR; Immunogenetics Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
DeOcesano-Pereira C; Center of Excellence in New Target Discovery, Butantan Institute, São Paulo 05503-900, Brazil.
Lichtenstein F; Center of Excellence in New Target Discovery, Butantan Institute, São Paulo 05503-900, Brazil.
Picolo G; Laboratory of Pain and Signaling, Butantan Institute, São Paulo 05503-900, Brazil.
Chudzinski-Tavassi AM; Center of Excellence in New Target Discovery, Butantan Institute, São Paulo 05503-900, Brazil.; Innovation and Development Laboratory, Innovation and Development Center, Butantan Institute, São Paulo 05503-900, Brazil.
Sampaio SC; Laboratory of Pathophysiology, Butantan Institute, São Paulo 05503-900, Brazil.; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-220, Brazil.
Cury Y; Laboratory of Pain and Signaling, Butantan Institute, São Paulo 05503-900, Brazil.
Zambelli VO; Laboratory of Pain and Signaling, Butantan Institute, São Paulo 05503-900, Brazil.; Center of Excellence in New Target Discovery, Butantan Institute, São Paulo 05503-900, Brazil.
Pokaż więcej
Źródło:
Cells [Cells] 2022 Jan 12; Vol. 11 (2). Date of Electronic Publication: 2022 Jan 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Evaluation, Preclinical*
Models, Biological*
Analgesics/*analysis
Analgesics/*pharmacology
Collagen/*pharmacology
Sensory Receptor Cells/*cytology
Animals ; Antigens, Neoplasm/metabolism ; Biomarkers/metabolism ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Extracellular Matrix/metabolism ; Galectin 3/metabolism ; Gene Expression Regulation/drug effects ; Glycosylation/drug effects ; Humans ; Mitogen-Activated Protein Kinases/metabolism ; NAV1.7 Voltage-Gated Sodium Channel/genetics ; NAV1.7 Voltage-Gated Sodium Channel/metabolism ; Neurites/drug effects ; Neurites/metabolism ; Neurons/cytology ; Neurons/drug effects ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Receptors, Neurokinin-1/genetics ; Receptors, Neurokinin-1/metabolism ; Sensory Receptor Cells/drug effects ; Sensory Receptor Cells/metabolism ; Substance P/metabolism ; beta-Endorphin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Microphysiological systems in absorption, distribution, metabolism, and elimination sciences.
Autorzy:
Van Ness KP; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Cesar F; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Yeung CK; Department of Pharmacy, University of Washington, Seattle, Washington, USA.; Kidney Research Institute, University of Washington, Seattle, Washington, USA.
Himmelfarb J; Kidney Research Institute, University of Washington, Seattle, Washington, USA.
Kelly EJ; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.; Kidney Research Institute, University of Washington, Seattle, Washington, USA.
Pokaż więcej
Źródło:
Clinical and translational science [Clin Transl Sci] 2022 Jan; Vol. 15 (1), pp. 9-42. Date of Electronic Publication: 2021 Aug 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Drug Development*
Drug Evaluation, Preclinical*
Models, Biological*
Prescription Drugs/*metabolism
Prescription Drugs/*pharmacokinetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 23461

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