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Tytuł:
ACFIS 2.0: an improved web-server for fragment-based drug discovery via a dynamic screening strategy.
Autorzy:
Shi XX; National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan430079, P.R. China.
Wang ZZ; National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan430079, P.R. China.
Wang F; National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan430079, P.R. China.
Hao GF; National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan430079, P.R. China.
Yang GF; National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan430079, P.R. China.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Jul 05; Vol. 51 (W1), pp. W25-W32.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Discovery*/instrumentation
Drug Discovery*/methods
Data Visualization*
Computer Simulation*
Drug Evaluation, Preclinical*/instrumentation
Drug Evaluation, Preclinical*/methods
Humans ; Depressive Disorder, Major/drug therapy ; Proteins/chemistry ; Neoplasms/drug therapy ; Parkinson Disease/drug therapy ; Internet
Czasopismo naukowe
Szczegóły
Tytuł:
Combined Experimental and Computational Study of V-Substituted Lindqvist Polyoxotungstate: Screening by Docking for Potential Antidiabetic Activity.
Autorzy:
Maalaoui A; Laboratory of Materials Chemistry, Faculty of Sciences of Bizerte, 7021 Zarzouna, Bizerte, Tunisia.
Agwamba EC; Department of Chemistry, Covenant University, Idiroko Road, P.M.B, Ota 1023, Ogun State, Nigeria.; Computational and Bio-Simulation Research Group, University of Calabar, P.M.B. 1115, Calabar 540221, Nigeria.
Louis H; Computational and Bio-Simulation Research Group, University of Calabar, P.M.B. 1115, Calabar 540221, Nigeria.; Department of Pure and Applied Chemistry, University of Calabar, P.M.B. 1115, Calabar 540221, Nigeria.
Mathias GE; Computational and Bio-Simulation Research Group, University of Calabar, P.M.B. 1115, Calabar 540221, Nigeria.; Department of Pure and Applied Chemistry, University of Calabar, P.M.B. 1115, Calabar 540221, Nigeria.
Rzaigui M; Laboratory of Materials Chemistry, Faculty of Sciences of Bizerte, 7021 Zarzouna, Bizerte, Tunisia.
Akriche S; Laboratory of Materials Chemistry, Faculty of Sciences of Bizerte, 7021 Zarzouna, Bizerte, Tunisia.
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Źródło:
Inorganic chemistry [Inorg Chem] 2023 Sep 04; Vol. 62 (35), pp. 14279-14290. Date of Electronic Publication: 2023 Aug 24.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoglycemic Agents*/chemistry
Drug Evaluation, Preclinical*/methods
Computer Simulation ; Tungsten Compounds/chemistry ; Polymers/chemistry ; Models, Molecular ; Protein Structure, Tertiary
Czasopismo naukowe
Szczegóły
Tytuł:
Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data.
Autorzy:
Potdar S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.
Ianevski F; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.
Ianevski A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.
Tanoli Z; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.
Wennerberg K; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
Seashore-Ludlow B; Department of Medical Biochemistry and Biophysics, Chemical Biology Consortium Sweden (CBCS), Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.; Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Kallioniemi O; Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Östling P; Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Aittokallio T; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Norway.; Centre for Biostatistics and Epidemiology (OCBE), Faculty of Medicine, University of Oslo, Norway.
Saarela J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Jul 05; Vol. 51 (W1), pp. W57-W61.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Evaluation, Preclinical*
Software*
Computer Graphics ; Reproducibility of Results ; User-Computer Interface ; Internet
Czasopismo naukowe
Szczegóły
Tytuł:
Computational approaches streamlining drug discovery.
Autorzy:
Sadybekov AV; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.; Center for New Technologies in Drug Discovery and Development, Bridge Institute, Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Katritch V; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA. .; Center for New Technologies in Drug Discovery and Development, Bridge Institute, Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA. .; Department of Chemistry, University of Southern California, Los Angeles, CA, USA. .
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Źródło:
Nature [Nature] 2023 Apr; Vol. 616 (7958), pp. 673-685. Date of Electronic Publication: 2023 Apr 26.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Drug Discovery*/instrumentation
Drug Discovery*/methods
Computer Simulation*
Drug Evaluation, Preclinical*/instrumentation
Drug Evaluation, Preclinical*/methods
Ligands ; Humans
Czasopismo naukowe
Szczegóły
Tytuł:
An animal-free preclinical drug screening platform based on human precision-cut kidney slices.
Autorzy:
Mutsaers HAM; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark. .
Jensen MS; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.
Kresse JC; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.
Tingskov SJ; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.
Madsen MG; Department of Urology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.
Nørregaard R; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.
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Źródło:
BMC research notes [BMC Res Notes] 2023 Mar 20; Vol. 16 (1), pp. 39. Date of Electronic Publication: 2023 Mar 20.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Evaluation, Preclinical*/methods
Kidney Diseases*/drug therapy
Renal Insufficiency, Chronic*
Animals ; Humans ; Fibrosis ; Kidney/pathology ; Transforming Growth Factor beta/genetics ; Animal Testing Alternatives
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of potent heat shock protein 90 (Hsp90) inhibitors: structure-based virtual screening, molecular dynamics simulation, and biological evaluation.
Autorzy:
Xu Y; Department of Pharmacy, Nantong First People's Hospital, Nantong, China.
Zou Y; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Zhou S; Department of Pharmacy, Nantong First People's Hospital, Nantong, China.
Niu MM; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Zhang Y; Department of Oncology, Urology and Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Li J; Department of Oncology, Urology and Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Xu Z; Department of Oncology, Urology and Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Yang L; Department of Oncology, Urology and Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2220558.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Discovery*
HSP90 Heat-Shock Proteins*/antagonists & inhibitors
Cell Line, Tumor ; Drug Evaluation, Preclinical/methods ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Docking Simulation ; Pharmacophore ; Humans ; Animals ; Mice
Czasopismo naukowe
Szczegóły
Tytuł:
Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application.
Autorzy:
Ren X; Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China; Department of Oncology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
Huang M; Department of Oncology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
Weng W; Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
Xie Y; Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
Wu Y; Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China; Department of Gastroenterology and Hepatology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
Zhu S; Department of Gastroenterology and Hepatology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
Zhang Y; Department of Oncology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
Li D; Center of Hepato-Pancreato-Biliary Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
Lai J; Center of Hepato-Pancreato-Biliary Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
Shen S; Center of Hepato-Pancreato-Biliary Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
Lin J; Second Department of General Surgery, Shunde Hospital, Southern Medical University, Foshan, Guangdong Province 528300, China.
Kuang M; Center of Hepato-Pancreato-Biliary Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
Li X; Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China. Electronic address: .
Yu J; Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China; Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: .
Xu L; Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China; Department of Oncology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China. Electronic address: .
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Źródło:
Cell reports. Medicine [Cell Rep Med] 2023 Nov 21; Vol. 4 (11), pp. 101277. Date of Electronic Publication: 2023 Nov 08.
Typ publikacji:
Journal Article
MeSH Terms:
Early Detection of Cancer*
Biliary Tract Neoplasms*/drug therapy
Biliary Tract Neoplasms*/genetics
Biliary Tract Neoplasms*/pathology
Humans ; Drug Evaluation, Preclinical ; Gemcitabine ; Organoids/pathology
Czasopismo naukowe
Szczegóły
Tytuł:
High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma.
Autorzy:
Arang N; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Lubrano S; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; Department of Pharmacy, University of Pisa, Pisa, Italy.
Ceribelli M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Rigiracciolo DC; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Saddawi-Konefka R; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Faraji F; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Ramirez SI; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Kim D; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Tosto FA; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Stevenson E; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA.
Zhou Y; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA.
Wang Z; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Bogomolovas J; School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Molinolo AA; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Swaney DL; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA.
Krogan NJ; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA.
Yang J; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Coma S; Verastem Oncology, Needham, MA 02494, USA.
Pachter JA; Verastem Oncology, Needham, MA 02494, USA.
Aplin AE; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Alessi DR; Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Gutkind JS; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: .
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Źródło:
Cell reports. Medicine [Cell Rep Med] 2023 Nov 21; Vol. 4 (11), pp. 101244. Date of Electronic Publication: 2023 Oct 18.
Typ publikacji:
Journal Article
MeSH Terms:
Melanoma*/drug therapy
Melanoma*/genetics
Melanoma*/pathology
Skin Neoplasms*
Uveal Neoplasms*/drug therapy
Uveal Neoplasms*/genetics
Uveal Neoplasms*/metabolism
Animals ; Mice ; GTP-Binding Protein alpha Subunits/genetics ; GTP-Binding Protein alpha Subunits/metabolism ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism ; GTP-Binding Protein alpha Subunits, Gq-G11/therapeutic use ; Drug Evaluation, Preclinical ; Protein Kinase Inhibitors/pharmacology
SCR Disease Name:
Uveal melanoma
Czasopismo naukowe
Szczegóły
Tytuł:
Current progress, strategy, and prospects of PD-1/PDL-1 immune checkpoint biosensing platforms for cancer diagnostics, therapy monitoring, and drug screening.
Autorzy:
Ratajczak K; Department of Physics and Biophysics, Warsaw University of Life Sciences (SGGW), 159 Nowoursynowska Street, 02776, Warsaw, Poland.
Grel H; Department of Physics and Biophysics, Warsaw University of Life Sciences (SGGW), 159 Nowoursynowska Street, 02776, Warsaw, Poland.
Olejnik P; Department of Physics and Biophysics, Warsaw University of Life Sciences (SGGW), 159 Nowoursynowska Street, 02776, Warsaw, Poland.
Jakiela S; Department of Physics and Biophysics, Warsaw University of Life Sciences (SGGW), 159 Nowoursynowska Street, 02776, Warsaw, Poland. Electronic address: slawomir_.
Stobiecka M; Department of Physics and Biophysics, Warsaw University of Life Sciences (SGGW), 159 Nowoursynowska Street, 02776, Warsaw, Poland. Electronic address: magdalena_.
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Źródło:
Biosensors & bioelectronics [Biosens Bioelectron] 2023 Nov 15; Vol. 240, pp. 115644. Date of Electronic Publication: 2023 Aug 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Biosensing Techniques*
Neoplasms*/diagnosis
Neoplasms*/drug therapy
Early Detection of Cancer ; Programmed Cell Death 1 Receptor ; Drug Evaluation, Preclinical ; Biomarkers, Tumor
Czasopismo naukowe
Szczegóły
Tytuł:
Deep-Learning Terahertz Single-Cell Metabolic Viability Study.
Autorzy:
Yang N; School of Electrical Information Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Shi Q; School of Electrical Information Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Wei M; School of Electrical Information Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Xiao Y; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.
Xia M; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.
Cai X; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Zhang X; School of Agricultural Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Wang W; School of Electrical Information Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Pan X; Animal Husbandry and Veterinary Research Institute, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu 210014, China.
Mao H; School of Agricultural Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Zou X; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Guo M; School of Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Zhang X; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.
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Źródło:
ACS nano [ACS Nano] 2023 Nov 14; Vol. 17 (21), pp. 21383-21393. Date of Electronic Publication: 2023 Sep 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Deep Learning*
Terahertz Spectroscopy*/methods
Neural Networks, Computer ; Cell Survival ; Drug Evaluation, Preclinical
Czasopismo naukowe
Szczegóły
Tytuł:
A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine.
Autorzy:
Steinberg E; The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Friedman R; School of Computer Science and Engineering, Center for Interdisciplinary Data Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
Goldstein Y; The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Friedman N; The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Beharier O; Hadassah Medical Center and The Hebrew University of Jerusalem, Jerusalem, Israel.
Demma JA; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Zamir G; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Hubert A; Oncology Department, Hadassah Medical Center, Jerusalem, Israel.
Benny O; The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. .
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Źródło:
Communications biology [Commun Biol] 2023 Nov 13; Vol. 6 (1), pp. 1157. Date of Electronic Publication: 2023 Nov 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Precision Medicine*
Neoplasms*/drug therapy
Neoplasms*/pathology
Humans ; Drug Evaluation, Preclinical ; Printing, Three-Dimensional ; Lab-On-A-Chip Devices ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Liver Extracellular Matrix-Based Nanofiber Scaffolds for the Culture of Primary Hepatocytes and Drug Screening.
Autorzy:
Vasudevan A; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.; Amity Institute of Biotechnology, Sector-125, Amity University Uttar Pradesh, Noida 201301, India.
Majumder N; Department of Textile and Fibre Engineering, Indian Institute of Technology Delhi, New Delhi 110016, India.
Sharma I; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Kaur I; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Sundarrajan S; Department of Mechanical Engineering, National University of Singapore, Singapore 117581, Singapore.; Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai 600077, India.
Venugopal JR; Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Kuantan 26600, Malaysia.
Vijayaraghavan P; Amity Institute of Biotechnology, Sector-125, Amity University Uttar Pradesh, Noida 201301, India.
Singh N; Centre for Biomedical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
Ramakrishna S; Department of Mechanical Engineering, National University of Singapore, Singapore 117581, Singapore.
Ghosh S; Department of Textile and Fibre Engineering, Indian Institute of Technology Delhi, New Delhi 110016, India.
M Tripathi D; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Kaur S; Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
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Źródło:
ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2023 Nov 13; Vol. 9 (11), pp. 6357-6368. Date of Electronic Publication: 2023 Oct 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nanofibers*
Rats ; Animals ; Drug Evaluation, Preclinical ; Tissue Scaffolds ; Hepatocytes/metabolism ; Liver ; Extracellular Matrix ; Collagen/metabolism ; Polyesters/pharmacology ; Polyesters/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Anti-influenza drug screening and inhibition of apigetrin on influenza A virus replication via TLR4 and autophagy pathways.
Autorzy:
He M; Department of Microbiology and Immunology, Shantou University Medical College, Shantou 515041, China; College of Pharmacy, Dali University, Dali 671000, Yunnan, China; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Ren Z; Department of Microbiology and Immunology, Shantou University Medical College, Shantou 515041, China; Department of Anesthesiology, The Second Xiangya Hospital,Central South University. Changsha 410011, Hunan Province, China.
Goraya MU; Department of Microbiology and Immunology, Shantou University Medical College, Shantou 515041, China; Institute of Microbiology, University of Agriculture Faisalabad, 38040, Pakistan.
Lin Y; Department of Microbiology and Immunology, Shantou University Medical College, Shantou 515041, China.
Ye J; Department of Microbiology and Immunology, Shantou University Medical College, Shantou 515041, China.
Li R; Department of Microbiology and Immunology, Shantou University Medical College, Shantou 515041, China.
Dai J; Department of Microbiology and Immunology, Shantou University Medical College, Shantou 515041, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2023 Nov; Vol. 124 (Pt B), pp. 110943. Date of Electronic Publication: 2023 Oct 05.
Typ publikacji:
Journal Article
MeSH Terms:
Influenza, Human*/drug therapy
Influenza A virus*/physiology
Humans ; NF-kappa B/metabolism ; Apigenin/therapeutic use ; Toll-Like Receptor 4/metabolism ; Drug Evaluation, Preclinical ; Hydrogen Peroxide/pharmacology ; Virus Replication ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Autophagy
Czasopismo naukowe
Szczegóły
Tytuł:
Mesenchymal stem cell-derived rapid drug screening system for Alzheimer's disease for the identification of novel drugs.
Autorzy:
Gamit N; Division of Cancer Stem Cells and Cardiovascular Regeneration, Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India.
Patil M; Division of Cancer Stem Cells and Cardiovascular Regeneration, Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India.
B Sundrappa S; Division of Cancer Stem Cells and Cardiovascular Regeneration, Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India.
Sundaram SM; Division of Cancer Stem Cells and Cardiovascular Regeneration, Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India.
Sethi G; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Dharmarajan A; Department of Biomedical Sciences, Faculty of Biomedical Sciences and Technology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
Warrier S; Division of Cancer Stem Cells and Cardiovascular Regeneration, Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India.; Cuor Stem Cellutions Pvt Ltd, Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India.; Department of Biotechnology, Faculty of Biomedical Sciences and Technology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
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Źródło:
Drug development research [Drug Dev Res] 2023 Nov; Vol. 84 (7), pp. 1496-1512. Date of Electronic Publication: 2023 Aug 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/metabolism
Mesenchymal Stem Cells*/metabolism
Animals ; Humans ; Amyloid Precursor Protein Secretases ; Probucol/metabolism ; Drug Evaluation, Preclinical ; Aspartic Acid Endopeptidases
Czasopismo naukowe
Szczegóły
Tytuł:
Antitumor effect of luteolin proven by patient-derived organoids of gastric cancer.
Autorzy:
Hao X; Department of Gastroenterology, Peking University Third Hospital, Beijing, China.; Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases (BZ0371), Beijing, China.
Zu M; Department of Gastroenterology, Peking University Third Hospital, Beijing, China.; Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases (BZ0371), Beijing, China.
Ning J; Department of Gastroenterology, Peking University Third Hospital, Beijing, China.; Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases (BZ0371), Beijing, China.
Zhou X; Department of General Surgery, Peking University Third Hospital, Beijing, China.
Gong Y; Department of Gastroenterology, Peking University Third Hospital, Beijing, China.; Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases (BZ0371), Beijing, China.
Han X; Department of Gastroenterology, Peking University Third Hospital, Beijing, China.; Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases (BZ0371), Beijing, China.
Meng Q; Department of Gastroenterology, Peking University Third Hospital, Beijing, China.; Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases (BZ0371), Beijing, China.
Li D; Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing, China.
Ding S; Department of Gastroenterology, Peking University Third Hospital, Beijing, China.; Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases (BZ0371), Beijing, China.
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Źródło:
Phytotherapy research : PTR [Phytother Res] 2023 Nov; Vol. 37 (11), pp. 5315-5327. Date of Electronic Publication: 2023 Jul 19.
Typ publikacji:
Journal Article
MeSH Terms:
Stomach Neoplasms*/drug therapy
Stomach Neoplasms*/metabolism
Humans ; Luteolin/pharmacology ; Carboplatin/metabolism ; Carboplatin/pharmacology ; Drug Evaluation, Preclinical ; Organoids/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Quantitative assessment of cardiomyocyte mechanobiology through high-throughput cantilever-based functional well plate systems.
Autorzy:
Kim J; MEMS and Nanotechnology Laboratory, School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Republic of Korea. .; Advanced Medical Device Research Center for Cardiovascular Disease, Chonnam National University, Gwangju 61186, Republic of Korea.
Shanmugasundaram A; MEMS and Nanotechnology Laboratory, School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Republic of Korea. .; Advanced Medical Device Research Center for Cardiovascular Disease, Chonnam National University, Gwangju 61186, Republic of Korea.
Kim DS; MEMS and Nanotechnology Laboratory, School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Republic of Korea. .; Advanced Medical Device Research Center for Cardiovascular Disease, Chonnam National University, Gwangju 61186, Republic of Korea.; Green Energy & Nano Technology R&D Group, Korea Institute of Industrial Technology (KITECH), Gwangju, 61012, Republic of Korea.
Jeong YJ; MEMS and Nanotechnology Laboratory, School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Republic of Korea. .; Advanced Medical Device Research Center for Cardiovascular Disease, Chonnam National University, Gwangju 61186, Republic of Korea.
Kanade PP; MEMS and Nanotechnology Laboratory, School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Republic of Korea. .; Advanced Medical Device Research Center for Cardiovascular Disease, Chonnam National University, Gwangju 61186, Republic of Korea.
Kim ES; Department of Biological Sciences, Chonnam National University, Gwangju, 61186, Republic of Korea.; Center for Next-Generation Sensor Research and Development, Chonnam National University, Gwangju 61186, Republic of Korea.
Lee BK; MEMS and Nanotechnology Laboratory, School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Republic of Korea. .; Center for Next-Generation Sensor Research and Development, Chonnam National University, Gwangju 61186, Republic of Korea.
Lee DW; MEMS and Nanotechnology Laboratory, School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Republic of Korea. .; Center for Next-Generation Sensor Research and Development, Chonnam National University, Gwangju 61186, Republic of Korea.; Advanced Medical Device Research Center for Cardiovascular Disease, Chonnam National University, Gwangju 61186, Republic of Korea.
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Źródło:
The Analyst [Analyst] 2023 Oct 05; Vol. 148 (20), pp. 5133-5143. Date of Electronic Publication: 2023 Oct 05.
Typ publikacji:
Journal Article
MeSH Terms:
Myocytes, Cardiac*
Drug-Related Side Effects and Adverse Reactions*/metabolism
Humans ; Cell Culture Techniques ; Verapamil/pharmacology ; Drug Evaluation, Preclinical ; Cells, Cultured
Czasopismo naukowe
Szczegóły
Tytuł:
Polyglycerol-Based Biomedical Matrix for Immunomagnetic Circulating Tumor Cell Isolation and Their Expansion into Tumor Spheroids for Drug Screening.
Autorzy:
Tang P; Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.
Thongrom B; Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.
Arora S; Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.
Haag R; Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.
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Źródło:
Advanced healthcare materials [Adv Healthc Mater] 2023 Oct; Vol. 12 (26), pp. e2300842. Date of Electronic Publication: 2023 Jul 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplastic Cells, Circulating*
Humans ; Drug Evaluation, Preclinical/methods ; Polymers/pharmacology ; Spheroids, Cellular ; Hydrogels/pharmacology ; Tumor Microenvironment
Czasopismo naukowe
Szczegóły
Tytuł:
Anesthetized guinea pig as a model for drug testing.
Autorzy:
Bartakova A; Department of Physiology, Faculty of Medicine, Masaryk University, Czech Republic. .
Novakova M
Stracina T
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Źródło:
Physiological research [Physiol Res] 2022 Dec 31; Vol. 71 (S2), pp. S211-S218.
Typ publikacji:
Journal Article
MeSH Terms:
Cardiovascular System*/drug effects
Electrocardiography*
Myocardial Contraction*/drug effects
Myocardial Contraction*/physiology
Drug Evaluation, Preclinical*
Animals ; Guinea Pigs ; Humans ; Heart/drug effects ; Heart/physiology ; Heart Rate ; Blood Pressure/drug effects ; Disease Models, Animal
Czasopismo naukowe
Szczegóły
Tytuł:
Development of non-bias phenotypic drug screening for cardiomyocyte hypertrophy by image segmentation using deep learning.
Autorzy:
Komuro J; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: sieg_.
Tokuoka Y; Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama-shi, Kanagawa, 223-8522, Japan. Electronic address: .
Seki T; Department of Healthcare Information Management, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. Electronic address: .
Kusumoto D; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Hashimoto H; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Katsuki T; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; Department of Cardiology, Saitama Municipal Hospital, 2460 Mimuro, Midori-ku, Saitama-shi, Saitama, Japan. Electronic address: .
Nakamura T; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Akiba Y; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Kuoka T; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Kimura M; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Yamada T; Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama-shi, Kanagawa, 223-8522, Japan. Electronic address: .
Fukuda K; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
Funahashi A; Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama-shi, Kanagawa, 223-8522, Japan. Electronic address: .
Yuasa S; Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Dec 03; Vol. 632, pp. 181-188. Date of Electronic Publication: 2022 Oct 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cardiomegaly*/diagnostic imaging
Cardiomegaly*/drug therapy
Deep Learning*
Drug Evaluation, Preclinical*/methods
Heart Failure*/drug therapy
Animals ; Mice ; Rats ; Angiotensin II/pharmacology ; Cells, Cultured ; Cholesterol ; Endothelin-1 ; Ezetimibe ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/drug effects
Czasopismo naukowe
Szczegóły
Tytuł:
A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasis.
Autorzy:
Sahu N
Grandi FC
Bhutani N
Pokaż więcej
Źródło:
JCI insight [JCI Insight] 2022 Oct 04; Vol. 7 (20). Date of Electronic Publication: 2022 Oct 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cartilage*/drug effects
Cartilage*/metabolism
Drug Evaluation, Preclinical*/methods
Osteoarthritis*/drug therapy
Osteoarthritis*/metabolism
Humans ; Homeostasis/drug effects ; NF-kappa B/metabolism ; Signal Transduction ; Single-Cell Analysis/instrumentation ; Single-Cell Analysis/methods
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 24577

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