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Wyszukujesz frazę ""Drug Partial Agonism"" wg kryterium: Temat


Tytuł :
Behavioral Effects of Opioid Full and Partial Agonists During Chronic Buprenorphine Treatment.
Autorzy :
Withey SL; Behavioral Biology Program, McLean Hospital/Harvard Medical School, Belmont, Massachusetts.
Spealman RD; Behavioral Biology Program, McLean Hospital/Harvard Medical School, Belmont, Massachusetts.
Bergman J; Behavioral Biology Program, McLean Hospital/Harvard Medical School, Belmont, Massachusetts.
Paronis CA; Behavioral Biology Program, McLean Hospital/Harvard Medical School, Belmont, Massachusetts .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2019 Nov; Vol. 371 (2), pp. 544-554. Date of Electronic Publication: 2019 Aug 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Journal Info :
Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J. Pharmacol. Exp. Ther. Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Analgesics, Opioid/*administration & dosage
Behavior, Addictive/*drug therapy
Buprenorphine/*administration & dosage
Pain Measurement/*drug effects
Receptors, Opioid, mu/*agonists
Animals ; Behavior, Addictive/psychology ; Dose-Response Relationship, Drug ; Male ; Morphine/administration & dosage ; Oxycodone/administration & dosage ; Pain Measurement/methods ; Receptors, Opioid, mu/metabolism ; Saimiri ; Self Administration
SCR Organism :
Saimiri boliviensis
Czasopismo naukowe
Tytuł :
Major Depressive Disorder (MDD) and Schizophrenia- Addressing Unmet Needs With Partial Agonists at the D2 Receptor: A Review.
Autorzy :
Mallet J; INSERM U1266, Institute of Psychiatry and Neurosciences of Paris (IPNP), France.; Psychiatry Department, University Hospital Louis Mourier; Paris Diderot University, France.
Gorwood P; INSERM U1266, Institute of Psychiatry and Neurosciences of Paris (IPNP), France.; GHU Paris, CMME, Sainte-Anne hospital; University of Paris, France.
Le Strat Y; INSERM U1266, Institute of Psychiatry and Neurosciences of Paris (IPNP), France.; Psychiatry Department, University Hospital Louis Mourier; Paris Diderot University, France.
Dubertret C; INSERM U1266, Institute of Psychiatry and Neurosciences of Paris (IPNP), France.; Psychiatry Department, University Hospital Louis Mourier; Paris Diderot University, France.
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Źródło :
The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2019 Oct 01; Vol. 22 (10), pp. 651-664.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Oxford University Press Country of Publication: England NLM ID: 9815893 Publication Model: Print Cited Medium: Internet ISSN: 1469-5111 (Electronic) Linking ISSN: 14611457 NLM ISO Abbreviation: Int. J. Neuropsychopharmacol. Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Antipsychotic Agents/*pharmacology
Antipsychotic Agents/*therapeutic use
Depressive Disorder, Major/*drug therapy
Receptors, Dopamine D2/*agonists
Schizophrenia/*drug therapy
Humans
Czasopismo naukowe
Tytuł :
A novel soluble guanylyl cyclase activator, BR 11257, acts as a non-stabilising partial agonist of sGC.
Autorzy :
Elgert C; Department of Pharmacology, Toxicology and Clinical Pharmacy, University of Braunschweig - Institute of Technology, Germany. Electronic address: .
Rühle A; Department of Pharmacology, Toxicology and Clinical Pharmacy, University of Braunschweig - Institute of Technology, Germany. Electronic address: .
Sandner P; Bayer AG, Drug Discovery, Wuppertal, Germany. Electronic address: .
Behrends S; Department of Pharmacology, Toxicology and Clinical Pharmacy, University of Braunschweig - Institute of Technology, Germany. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2019 May; Vol. 163, pp. 142-153. Date of Electronic Publication: 2019 Feb 10.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem. Pharmacol. Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Benzoates/*pharmacology
Biphenyl Compounds/*pharmacology
Enzyme Activators/*pharmacology
Hydrocarbons, Fluorinated/*pharmacology
Soluble Guanylyl Cyclase/*metabolism
Animals ; Benzoates/chemistry ; Biphenyl Compounds/chemistry ; Cell Line ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Enzyme Activation/physiology ; Enzyme Activators/chemistry ; Humans ; Hydrocarbons, Fluorinated/chemistry ; Insecta ; Male ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Countering Opioid-induced Respiratory Depression in Male Rats with Nicotinic Acetylcholine Receptor Partial Agonists Varenicline and ABT 594.
Autorzy :
Ren J; From the Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.
Ding X
Greer JJ
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Źródło :
Anesthesiology [Anesthesiology] 2020 May; Vol. 132 (5), pp. 1197-1211.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1300217 Publication Model: Print Cited Medium: Internet ISSN: 1528-1175 (Electronic) Linking ISSN: 00033022 NLM ISO Abbreviation: Anesthesiology Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Analgesics, Opioid/*toxicity
Azetidines/*administration & dosage
Nicotinic Agonists/*administration & dosage
Pyridines/*administration & dosage
Receptors, Nicotinic/*physiology
Respiratory Insufficiency/*prevention & control
Varenicline/*administration & dosage
Animals ; Drug Partial Agonism ; Male ; Rats ; Rats, Sprague-Dawley ; Respiratory Insufficiency/chemically induced ; Respiratory Insufficiency/physiopathology
Czasopismo naukowe
Tytuł :
Assessment of false transmitters as treatments for nerve agent poisoning.
Autorzy :
Whitmore C; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK. Electronic address: .
Lindsay CD; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Bird M; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Gore SJ; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Rice H; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Williams RL; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Timperley CM; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Green AC; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Mar 15; Vol. 321, pp. 21-31. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol. Lett. Subsets: MEDLINE
MeSH Terms :
Acetylcholine/*analogs & derivatives
Antidotes/*pharmacology
Choline/*analogs & derivatives
Cholinesterase Inhibitors/*poisoning
Diaphragm/*innervation
Nerve Agents/*poisoning
Neurotransmitter Agents/*pharmacology
Organophosphate Poisoning/*drug therapy
Soman/*poisoning
Synapses/*drug effects
Acetylcholine/chemical synthesis ; Acetylcholine/metabolism ; Acetylcholine/pharmacology ; Acetylcholinesterase/metabolism ; Animals ; Antidotes/chemical synthesis ; CHO Cells ; Cell Line, Tumor ; Choline/chemical synthesis ; Choline/pharmacology ; Cricetulus ; Drug Partial Agonism ; Guinea Pigs ; Humans ; Male ; Neurotransmitter Agents/chemical synthesis ; Organophosphate Poisoning/enzymology ; Organophosphate Poisoning/physiopathology ; Receptors, Cholinergic/drug effects ; Receptors, Cholinergic/genetics ; Receptors, Cholinergic/metabolism ; Synapses/enzymology
Czasopismo naukowe
Tytuł :
New insight into isobolographic analysis for combinations of a full and partial agonist: Curved isoboles.
Autorzy :
Ezechiáš M; Laboratory of Environmental Biotechnology, Institute of Microbiology of the CAS, v.v.i., Vídeňská 1083, Prague, 142 20, Czech Republic. Electronic address: .
Cajthaml T; Laboratory of Environmental Biotechnology, Institute of Microbiology of the CAS, v.v.i., Vídeňská 1083, Prague, 142 20, Czech Republic; Institute for Environmental Studies, Faculty of Science, Charles University in Prague, Albertov 6, Prague, 128 43, Czech Republic.
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Źródło :
Toxicology [Toxicology] 2018 Jun 01; Vol. 402-403, pp. 9-16. Date of Electronic Publication: 2018 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Models, Theoretical*
Dose-Response Relationship, Drug ; Drug Interactions/physiology ; Drug Synergism
Czasopismo naukowe
Tytuł :
Molecular determinants of PPARγ partial agonism and related in silico/in vivo studies of natural saponins as potential type 2 diabetes modulators.
Autorzy :
Al Sharif M; Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 105, 1113 Sofia, Bulgaria. Electronic address: .
Alov P; Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 105, 1113 Sofia, Bulgaria. Electronic address: .
Diukendjieva A; Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 105, 1113 Sofia, Bulgaria. Electronic address: .
Vitcheva V; Faculty of Pharmacy, Medical University of Sofia, Dunav 2 Str., 1000 Sofia, Bulgaria. Electronic address: .
Simeonova R; Faculty of Pharmacy, Medical University of Sofia, Dunav 2 Str., 1000 Sofia, Bulgaria. Electronic address: .
Krasteva I; Faculty of Pharmacy, Medical University of Sofia, Dunav 2 Str., 1000 Sofia, Bulgaria. Electronic address: .
Shkondrov A; Faculty of Pharmacy, Medical University of Sofia, Dunav 2 Str., 1000 Sofia, Bulgaria. Electronic address: .
Tsakovska I; Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 105, 1113 Sofia, Bulgaria. Electronic address: .
Pajeva I; Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 105, 1113 Sofia, Bulgaria. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2018 Feb; Vol. 112, pp. 47-59. Date of Electronic Publication: 2017 Dec 13.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem. Toxicol. Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Antioxidants/*therapeutic use
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*therapeutic use
PPAR gamma/*agonists
Saponins/*therapeutic use
Animals ; Biomarkers/metabolism ; Blood Glucose/metabolism ; Catalase/metabolism ; Computer Simulation ; Diabetes Mellitus, Type 2/blood ; Disease Models, Animal ; Homeostasis ; Humans ; Male ; Molecular Docking Simulation ; Oxidative Stress ; Pioglitazone ; Rats, Inbred SHR ; Superoxide Dismutase/metabolism ; Thiazolidinediones/therapeutic use
Czasopismo naukowe
Tytuł :
Study on the effect of EMD386088, a 5-HT 6 receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats.
Autorzy :
Jastrzębska-Więsek M; Department of Clinical Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Cracow, Poland. .
Siwek A; Department of Pharmacobiology, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Cracow, Poland.
Partyka A; Department of Clinical Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Cracow, Poland.
Kołaczkowski M; Department of Pharmaceutical Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Cracow, Poland.; Adamed Ltd., Pienków 149, 05-152, Czosnów, Poland.
Walczak M; Department of Toxicology, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Cracow, Poland.
Smolik M; Department of Toxicology, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Cracow, Poland.
Latacz G; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Cracow, Poland.
Kieć-Kononowicz K; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Cracow, Poland.
Wesołowska A; Department of Clinical Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Cracow, Poland.
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Źródło :
Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2018 Jan; Vol. 391 (1), pp. 37-49. Date of Electronic Publication: 2017 Oct 27.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Antidepressive Agents/*administration & dosage
Immobilization/*psychology
Indoles/*administration & dosage
Pyridines/*administration & dosage
Receptors, Serotonin/*metabolism
Animals ; Drug Synergism ; Immobilization/methods ; Immobilization/physiology ; Male ; Motor Activity/drug effects ; Motor Activity/physiology ; Rats ; Rats, Wistar ; Swimming/physiology
Czasopismo naukowe
Tytuł :
The Role of Dopamine D 3 Receptor Partial Agonism in Cariprazine-Induced Neurotransmitter Efflux in Rat Hippocampus and Nucleus Accumbens.
Autorzy :
Huang M; Department of Psychiatry and Behavior Science, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.H., W.H., H.Y.M.); Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary (B.K., B.F.); and Allergan, Madison, New Jersey (N.A.).
He W; Department of Psychiatry and Behavior Science, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.H., W.H., H.Y.M.); Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary (B.K., B.F.); and Allergan, Madison, New Jersey (N.A.) .
Kiss B; Department of Psychiatry and Behavior Science, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.H., W.H., H.Y.M.); Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary (B.K., B.F.); and Allergan, Madison, New Jersey (N.A.).
Farkas B; Department of Psychiatry and Behavior Science, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.H., W.H., H.Y.M.); Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary (B.K., B.F.); and Allergan, Madison, New Jersey (N.A.).
Adham N; Department of Psychiatry and Behavior Science, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.H., W.H., H.Y.M.); Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary (B.K., B.F.); and Allergan, Madison, New Jersey (N.A.).
Meltzer HY; Department of Psychiatry and Behavior Science, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.H., W.H., H.Y.M.); Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary (B.K., B.F.); and Allergan, Madison, New Jersey (N.A.) .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2019 Nov; Vol. 371 (2), pp. 517-525. Date of Electronic Publication: 2019 Sep 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J. Pharmacol. Exp. Ther. Subsets: MEDLINE
MeSH Terms :
Dopamine Agonists/*pharmacology
Hippocampus/*metabolism
Neurotransmitter Agents/*metabolism
Nucleus Accumbens/*metabolism
Piperazines/*pharmacology
Receptors, Dopamine D3/*metabolism
Animals ; Antipsychotic Agents/pharmacology ; Drug Partial Agonism ; Hippocampus/drug effects ; Male ; Microdialysis/methods ; Nucleus Accumbens/drug effects ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D3/agonists
Czasopismo naukowe
Tytuł :
Functional Characterization of 5-HT 1B Receptor Drugs in Nonhuman Primates Using Simultaneous PET-MR.
Autorzy :
Hansen HD; Neurobiology Research Unit and NeuroPharm, Copenhagen University Hospital (Rigshospitalet), 2100 Copenhagen, Denmark, .
Mandeville JB; MGH/HST A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and.
Sander CY; MGH/HST A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and.
Hooker JM; MGH/HST A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and.
Catana C; MGH/HST A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and.
Rosen BR; MGH/HST A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and.
Knudsen GM; Neurobiology Research Unit and NeuroPharm, Copenhagen University Hospital (Rigshospitalet), 2100 Copenhagen, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2017 Nov 01; Vol. 37 (44), pp. 10671-10678. Date of Electronic Publication: 2017 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info :
Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J. Neurosci. Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Brain/*metabolism
Magnetic Resonance Imaging/*methods
Positron-Emission Tomography/*methods
Serotonin 5-HT1 Receptor Agonists/*metabolism
Serotonin 5-HT1 Receptor Antagonists/*metabolism
Animals ; Brain/diagnostic imaging ; Brain/drug effects ; Dose-Response Relationship, Drug ; Macaca mulatta ; Male ; Receptor, Serotonin, 5-HT1B/metabolism ; Serotonin 5-HT1 Receptor Agonists/pharmacology ; Serotonin 5-HT1 Receptor Antagonists/pharmacology
Czasopismo naukowe
Tytuł :
Standard Curves Are Necessary to Determine Pharmacological Properties for Ligands in Functional Assays Using Competition Binding Technologies.
Autorzy :
Burford NT; 1 Bristol-Myers Squibb Company , Wallingford, Connecticut.
Watson J; 1 Bristol-Myers Squibb Company , Wallingford, Connecticut.
Alt A; 2 Arvinas, Inc. , New Haven, Connecticut.
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Źródło :
Assay and drug development technologies [Assay Drug Dev Technol] 2017 Oct/Nov; Vol. 15 (7), pp. 320-329.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101151468 Publication Model: Print Cited Medium: Internet ISSN: 1557-8127 (Electronic) Linking ISSN: 1540658X NLM ISO Abbreviation: Assay Drug Dev Technol Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Binding, Competitive/*physiology
Cyclic AMP/*metabolism
Fluorescence Resonance Energy Transfer/*methods
Glucagon-Like Peptide 1/*metabolism
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; Humans ; Ligands
Czasopismo naukowe
Tytuł :
Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents.
Autorzy :
Pieschl RL; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Miller R; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Jones KM; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Post-Munson DJ; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Chen P; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Newberry K; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Benitex Y; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Molski T; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Morgan D; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
McDonald IM; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Macor JE; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Olson RE; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Asaka Y; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Digavalli S; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Easton A; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Herrington J; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Westphal RS; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Lodge NJ; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Zaczek R; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Bristow LJ; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA.
Li YW; Bristol-Myers Squibb Company, Department of Neuroscience, 5 Research Parkway, Wallingford, CT 06492, USA. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2017 Jul 15; Vol. 807, pp. 1-11. Date of Electronic Publication: 2017 Apr 22.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur. J. Pharmacol. Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Cognition/*drug effects
Nicotinic Agonists/*pharmacology
Quinuclidines/*pharmacology
Sensory Gating/*drug effects
Spiro Compounds/*pharmacology
alpha7 Nicotinic Acetylcholine Receptor/*agonists
Animals ; Attention/drug effects ; Dose-Response Relationship, Drug ; HEK293 Cells ; Hippocampus/drug effects ; Hippocampus/physiology ; Humans ; Long-Term Potentiation/drug effects ; Male ; Memory/drug effects ; Mice ; Rats
Czasopismo naukowe
Tytuł :
Capadenoson, a clinically trialed partial adenosine A 1 receptor agonist, can stimulate adenosine A 2B receptor biased agonism.
Autorzy :
Baltos JA; Drug Discovery Biology & Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Vecchio EA; Drug Discovery Biology & Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Harris MA; Drug Discovery Biology & Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Qin CX; Heart Failure Pharmacology, Baker IDI Heart & Diabetes Institute, Melbourne, VIC 3004, Australia.
Ritchie RH; Heart Failure Pharmacology, Baker IDI Heart & Diabetes Institute, Melbourne, VIC 3004, Australia.
Christopoulos A; Drug Discovery Biology & Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
White PJ; Drug Discovery Biology & Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
May LT; Drug Discovery Biology & Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2017 Jul 01; Vol. 135, pp. 79-89. Date of Electronic Publication: 2017 Mar 23.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem. Pharmacol. Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Adenosine A1 Receptor Agonists/*pharmacology
Adenosine A2 Receptor Agonists/*pharmacology
Aminopyridines/*pharmacology
Receptor, Adenosine A1/*physiology
Receptor, Adenosine A2B/*physiology
Thiazoles/*pharmacology
Animals ; Animals, Newborn ; CHO Cells ; Cells, Cultured ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/physiology ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Novel BQCA- and TBPB-Derived M 1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism.
Autorzy :
Schramm S; Pharmazeutische und Medizinische Chemie, Institut für Pharmazie und Lebensmittelchemie, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.
Agnetta L; Pharmazeutische und Medizinische Chemie, Institut für Pharmazie und Lebensmittelchemie, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.
Bermudez M; Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Strasse 2+4, 14195, Berlin, Germany.
Gerwe H; Pharmazeutische und Medizinische Chemie, Institut für Pharmazie und Lebensmittelchemie, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.
Irmen M; Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Strasse 3, 53121, Bonn, Germany.
Holze J; Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Strasse 3, 53121, Bonn, Germany.
Littmann T; Institute of Pharmacy, University of Regensburg, 93053, Regensburg, Germany.
Wolber G; Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Strasse 2+4, 14195, Berlin, Germany.
Tränkle C; Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Strasse 3, 53121, Bonn, Germany.
Decker M; Pharmazeutische und Medizinische Chemie, Institut für Pharmazie und Lebensmittelchemie, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.
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Źródło :
ChemMedChem [ChemMedChem] 2019 Jul 17; Vol. 14 (14), pp. 1349-1358. Date of Electronic Publication: 2019 Jul 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
MeSH Terms :
Benzimidazoles/*pharmacology
Carbachol/*analogs & derivatives
Carbachol/*pharmacology
Piperidines/*pharmacology
Quinolines/*pharmacology
Receptor, Muscarinic M1/*agonists
Benzimidazoles/agonists ; Benzimidazoles/chemical synthesis ; Benzimidazoles/metabolism ; Carbachol/agonists ; Carbachol/metabolism ; Drug Partial Agonism ; HEK293 Cells ; Humans ; Ligands ; Molecular Docking Simulation ; Muscarinic Agonists/chemical synthesis ; Muscarinic Agonists/metabolism ; Muscarinic Agonists/pharmacology ; Piperidines/agonists ; Piperidines/chemical synthesis ; Piperidines/metabolism ; Quinolines/agonists ; Quinolines/chemical synthesis ; Quinolines/metabolism ; Receptor, Muscarinic M1/metabolism
Czasopismo naukowe
Tytuł :
The Partial AdeNosine A1 receptor agonist in patients with Chronic Heart failure and preserved Ejection fraction (PANACHE) trial.
Autorzy :
Bertero E; Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Am Schwarzenberg 15, Haus A15, Würzburg, Germany.
Maack C; Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Am Schwarzenberg 15, Haus A15, Würzburg, Germany.
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Źródło :
Cardiovascular research [Cardiovasc Res] 2019 Jul 01; Vol. 115 (8), pp. e71-e73.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc. Res. Subsets: MEDLINE
MeSH Terms :
Adenosine A1 Receptor Agonists/*therapeutic use
Dipeptides/*therapeutic use
Heart Failure/*drug therapy
Pyridines/*therapeutic use
Receptor, Adenosine A1/*drug effects
Ventricular Function, Left/*drug effects
Adenosine A1 Receptor Agonists/adverse effects ; Animals ; Clinical Trials, Phase II as Topic ; Dipeptides/adverse effects ; Drug Partial Agonism ; Heart Failure/diagnosis ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Humans ; Multicenter Studies as Topic ; Pyridines/adverse effects ; Randomized Controlled Trials as Topic ; Receptor, Adenosine A1/metabolism ; Recovery of Function ; Signal Transduction ; Stroke Volume ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Occupancy of dopamine D 2 and D 3 receptors by a novel D3 partial agonist BP1.4979: a [ C]-(+)-PHNO PET study in humans.
Autorzy :
Di Ciano P; Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON, M5S 2S1, Canada.
Mansouri E; Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, M5S 2S1, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Canada.
Tong J; Preclinical imaging, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, M5S 2S1, Canada.; Human Brain Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, M5S 2S1, Canada.
Wilson AA; Institute of Medical Sciences, University of Toronto, Toronto, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, M5S 2S1, Canada.; Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.
Houle S; Institute of Medical Sciences, University of Toronto, Toronto, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, M5S 2S1, Canada.; Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.
Boileau I; Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, M5S 2S1, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, M5S 2S1, Canada.; Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.; Addiction Program, Centre for Addiction and Mental Health, Toronto, ON, M5S 2S1, Canada.
Duvauchelle T; Bioprojet, Paris, France.
Robert P; Bioprojet Biotech, Saint Grégoire, France.
Schwartz JC; Bioprojet, Paris, France.
Le Foll B; Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON, M5S 2S1, Canada. .; Institute of Medical Sciences, University of Toronto, Toronto, Canada. .; Department of Psychiatry, University of Toronto, Toronto, Canada. .; Addiction Program, Centre for Addiction and Mental Health, Toronto, ON, M5S 2S1, Canada. .; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada. .
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Źródło :
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2019 Jun; Vol. 44 (7), pp. 1284-1290. Date of Electronic Publication: 2018 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
MeSH Terms :
Brain/*drug effects
Brain/*metabolism
Dopamine Agonists/*pharmacokinetics
Receptors, Dopamine D2/*agonists
Receptors, Dopamine D2/*metabolism
Receptors, Dopamine D3/*agonists
Receptors, Dopamine D3/*metabolism
Adult ; Dopamine Agonists/administration & dosage ; Dose-Response Relationship, Drug ; Drug Partial Agonism ; Female ; Humans ; Male ; Oxazines ; Positron-Emission Tomography
Czasopismo naukowe
Tytuł :
Neurochemical and behavioural effects of hypidone hydrochloride (YL-0919): a novel combined selective 5-HT reuptake inhibitor and partial 5-HT 1A agonist.
Autorzy :
Zhang LM; Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Wang XY; Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhao N; Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Wang YL; Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Hu XX; Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Ran YH; Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Liu YQ; Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Zhang YZ; Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Yang RF; Department of Medicinal Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Li YF; Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2017 May; Vol. 174 (9), pp. 769-780. Date of Electronic Publication: 2017 Mar 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br. J. Pharmacol. Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Antidepressive Agents/*metabolism
Piperidines/*metabolism
Pyridones/*metabolism
Receptor, Serotonin, 5-HT1A/*metabolism
Serotonin 5-HT1 Receptor Agonists/*metabolism
Serotonin Uptake Inhibitors/*metabolism
Animals ; Anti-Anxiety Agents/metabolism ; Anti-Anxiety Agents/pharmacology ; Antidepressive Agents/pharmacology ; Avoidance Learning/drug effects ; Avoidance Learning/physiology ; Dose-Response Relationship, Drug ; Female ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; Mice ; Mice, Inbred ICR ; Microdialysis/methods ; Piperidines/pharmacology ; Pyridones/pharmacology ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Serotonin 5-HT1 Receptor Agonists/pharmacology ; Serotonin Uptake Inhibitors/pharmacology ; Sexual Behavior, Animal/drug effects ; Sexual Behavior, Animal/physiology
Czasopismo naukowe
Tytuł :
Safety and Tolerability of Neladenoson Bialanate, a Novel Oral Partial Adenosine A1 Receptor Agonist, in Patients With Chronic Heart Failure.
Autorzy :
Voors AA; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Düngen HD; Department of Cardiology, Campus Virchow, Charite Universitätsmedizin Berlin, Berlin, Germany.
Senni M; Cardiovascular Department, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Nodari S; Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University and Civil Hospital of Brescia, Brescia, Italy.
Agostoni P; Centro Cardiologico Monzino, Milan, Italy.
Ponikowski P; Wroclaw Medical University, Wroclaw, Poland.
Bax JJ; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Butler J; Division of Cardiology, Stony Brook University, Stony Brook, NY, USA.
Kim RJ; Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, NC, USA.
Dorhout B; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Dinh W; Department of Cardiology, Witten, Germany; Drug Discovery, Clinical Sciences, Bayer Pharma AG, Witten University, Wuppertal, Germany.
Gheorghiade M; Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
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Źródło :
Journal of clinical pharmacology [J Clin Pharmacol] 2017 Apr; Vol. 57 (4), pp. 440-451. Date of Electronic Publication: 2016 Nov 09.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Adenosine A1 Receptor Agonists/*administration & dosage
Heart Failure/*diagnosis
Heart Failure/*drug therapy
Administration, Oral ; Aged ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Chronic Disease ; Double-Blind Method ; Electrocardiography/drug effects ; Electrocardiography/methods ; Female ; Follow-Up Studies ; Heart Conduction System/drug effects ; Heart Conduction System/physiology ; Heart Failure/physiopathology ; Heart Rate/drug effects ; Heart Rate/physiology ; Humans ; Male ; Middle Aged ; Pilot Projects ; Single-Blind Method
Czasopismo naukowe
Tytuł :
My Dad Can Beat Your Dad: Agonists, Antagonists, Partial Agonists, and Inverse Agonists.
Autorzy :
Kowalski PC; Peter C. Kowalski, MD, is a Child, Adolescent, and Adult Psychiatrist at the Behavioral Health Center of Eastern Idaho Regional Medical Center, Idaho Falls, Idaho, USA.
Dowben JS; Jonathan S. Dowben, MD, is a Staff Psychiatrist, Child and Family, Behavioral Health Service, Brooke Army Medical Center (BAMC), Fort Sam Houston, Texas, USA.
Keltner NL; Norman L. Keltner, EdD, CRNP, is a Professor, School of Nursing (retired), University of Alabama at Birmingham, Birmingham, Alabama, USA.
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Źródło :
Perspectives in psychiatric care [Perspect Psychiatr Care] 2017 Apr; Vol. 53 (2), pp. 76-79. Date of Electronic Publication: 2017 Jan 16.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Nursing Publications] Country of Publication: United States NLM ID: 0401133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-6163 (Electronic) Linking ISSN: 00315990 NLM ISO Abbreviation: Perspect Psychiatr Care Subsets: Nursing
MeSH Terms :
Drug Antagonism*
Drug Inverse Agonism*
Drug Partial Agonism*
Neurotransmitter Agents/*agonists
Neurotransmitter Agents/*antagonists & inhibitors
Parkinson Disease/*drug therapy
Psychotic Disorders/*drug therapy
Humans ; Parkinson Disease/complications ; Psychotic Disorders/etiology
Czasopismo naukowe
Tytuł :
Translational Pharmacology of the Metabotropic Glutamate 2 Receptor-Preferring Agonist LY2812223 in the Animal and Human Brain.
Autorzy :
Felder CC; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.) .
Schober DA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
Tu Y; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
Quets A; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
Xiao H; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
Watt M; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
Siuda E; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
Nisenbaum E; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
Xiang C; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
Heinz B; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
Prieto L; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
McKinzie DL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
Monn JA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.C.F., D.A.S., Y.T., A.Q., H.X., M.W., E.S., E.N., C.X., B.H., D.L.M., J.A.M.); and Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain (L.P.).
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2017 Apr; Vol. 361 (1), pp. 190-197. Date of Electronic Publication: 2017 Jan 30.
Typ publikacji :
Journal Article
Journal Info :
Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J. Pharmacol. Exp. Ther. Subsets: MEDLINE
MeSH Terms :
Drug Partial Agonism*
Brain/*drug effects
Bridged Bicyclo Compounds/*pharmacology
Excitatory Amino Acid Agonists/*pharmacology
Receptors, Metabotropic Glutamate/*agonists
Triazoles/*pharmacology
Animals ; Brain/metabolism ; Bridged Bicyclo Compounds/metabolism ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Agonists/metabolism ; Humans ; Mice ; Mice, Knockout ; Protein Binding/drug effects ; Protein Binding/physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/metabolism ; Translational Medical Research ; Triazoles/metabolism
Czasopismo naukowe

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