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Wyszukujesz frazę ""Drug Repositioning"" wg kryterium: Temat


Tytuł :
Targeting multiple conformations of SARS-CoV2 Papain-Like Protease for drug repositioning: An in-silico study.
Autorzy :
Ismail MI; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt, Al-Sherouk City, Cairo-Suez Desert Road, 11837, Cairo, Egypt.
Ragab HM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt.
Bekhit AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt; Pharmacy Program, Allied Health Department, College of Health and Sport Sciences, University of Bahrain, P.O. Box 32038, Bahrain.
Ibrahim TM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt. Electronic address: .
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Źródło :
Computers in biology and medicine [Comput Biol Med] 2021 Apr; Vol. 131, pp. 104295. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Coronavirus 3C Proteases*/antagonists & inhibitors
Coronavirus 3C Proteases*/chemistry
Drug Repositioning*
Molecular Dynamics Simulation*
Cysteine Proteinase Inhibitors/*chemistry
SARS-CoV-2/*enzymology
Binding Sites ; Crystallography, X-Ray ; Enzyme Stability ; Humans
Czasopismo naukowe
Tytuł :
In silico drug repositioning based on the integration of chemical, genomic and pharmacological spaces.
Autorzy :
Chen H; School of Software, East China Jiaotong University, Nanchang, 330013, China. .
Zhang Z; School of Computer Science and Engineering, Central South University, Changsha, 410083, China.
Zhang J; School of Computer and Data Science, Henan University of Urban Construction, Pingdingshan, 467000, China.
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Feb 08; Vol. 22 (1), pp. 52. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
Genomics*
Algorithms ; Computational Biology ; Computer Simulation ; Databases, Factual
Czasopismo naukowe
Tytuł :
Raloxifene as a treatment option for viral infections.
Autorzy :
Hong S; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Chang J; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Jeong K; Bio-center, Gyeonggido Business & Science Accelerator, Suwon, 16229, Republic of Korea. .
Lee W; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. .
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Źródło :
Journal of microbiology (Seoul, Korea) [J Microbiol] 2021 Feb; Vol. 59 (2), pp. 124-131. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Repositioning*
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Raloxifene Hydrochloride/*therapeutic use
SARS-CoV-2/*drug effects
Estrogen Antagonists/therapeutic use ; Estrogens/agonists ; Humans ; Molecular Docking Simulation ; Osteoporosis, Postmenopausal/drug therapy ; Selective Estrogen Receptor Modulators/therapeutic use
Czasopismo naukowe
Tytuł :
Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions.
Autorzy :
Gheware A; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Dholakia D; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Kannan S; Center for High Computing, CSIR- Central Leather Research Institute (CLRI), Chennai, 600020, India.
Panda L; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Rani R; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Pattnaik BR; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India.
Jain V; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Parekh Y; CSIR-Center for Cellular and Molecular Biology, Annexe-II, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, 500007, India.
Enayathullah MG; CSIR-Center for Cellular and Molecular Biology, Annexe-II, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, 500007, India.
Bokara KK; CSIR-Center for Cellular and Molecular Biology, Annexe-II, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, 500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Subramanian V; Center for High Computing, CSIR- Central Leather Research Institute (CLRI), Chennai, 600020, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Mukerji M; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Agrawal A; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India. .; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. .
Prasher B; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India. .; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India. .; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India. .; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. .
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Źródło :
Respiratory research [Respir Res] 2021 Apr 06; Vol. 22 (1), pp. 99. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
Justicia*/chemistry
Anti-Inflammatory Agents/*pharmacology
COVID-19/*drug therapy
Hypoxia/*drug therapy
Lung/*drug effects
Plant Extracts/*pharmacology
Pneumonia/*prevention & control
Pulmonary Fibrosis/*drug therapy
Sepsis/*drug therapy
Animals ; Anti-Inflammatory Agents/isolation & purification ; Bleomycin ; COVID-19/metabolism ; COVID-19/virology ; Cecum/microbiology ; Cecum/surgery ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Hypoxia/genetics ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Hypoxia-Inducible Factor-Proline Dioxygenases/genetics ; Hypoxia-Inducible Factor-Proline Dioxygenases/metabolism ; Inflammation Mediators/metabolism ; Ligation ; Lung/metabolism ; Lung/microbiology ; Lung/pathology ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Plant Extracts/isolation & purification ; Pneumonia/genetics ; Pneumonia/metabolism ; Pneumonia/microbiology ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/genetics ; Pulmonary Fibrosis/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Sepsis/genetics ; Sepsis/metabolism ; Sepsis/microbiology ; Transcriptome
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Combating COVID-19: The role of drug repurposing and medicinal plants.
Autorzy :
Khan SA; College of Pharmacy, National University of Science and Technology, PO Box 620, PC 130, Muscat, Oman. Electronic address: .
Al-Balushi K; College of Pharmacy, National University of Science and Technology, PO Box 620, PC 130, Muscat, Oman.
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Źródło :
Journal of infection and public health [J Infect Public Health] 2021 Apr; Vol. 14 (4), pp. 495-503. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Repositioning*
Plants, Medicinal*
COVID-19/*drug therapy
Antiviral Agents/therapeutic use ; Humans ; Phytotherapy
Czasopismo naukowe
Tytuł :
[Antineoplasic drug repurposing in hematology for COVID-19 treatment].
Autorzy :
Tazi I; Université Cadi Ayyad, faculté de médecine, CHU Mohamed VI, service d'hématologie clinique, Marrakech, Maroc. Electronic address: .
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Transliterated Title :
Repositionnement des antinéoplasiques utilisés en hématologie dans le traitement du COVID-19.
Źródło :
Bulletin du cancer [Bull Cancer] 2021 Apr; Vol. 108 (4), pp. 435-437. Date of Electronic Publication: 2021 Feb 20.
Typ publikacji :
Letter
MeSH Terms :
Drug Repositioning*
COVID-19/*drug therapy
Hematologic Neoplasms/*drug therapy
Adenine/analogs & derivatives ; Adenine/therapeutic use ; Aniline Compounds/therapeutic use ; Humans ; Imatinib Mesylate/therapeutic use ; Janus Kinases/antagonists & inhibitors ; Nitriles/therapeutic use ; Oligopeptides/therapeutic use ; Piperidines/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Pyrazoles/therapeutic use ; Pyrimidines/therapeutic use ; Quinolines/therapeutic use
SCR Protocol :
COVID-19 drug treatment
Opinia redakcyjna
Tytuł :
In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.
Autorzy :
Sun L; MOE Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Li P; MOE Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Ju X; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 100084, China.
Rao J; NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Huang W; MOE Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Ren L; NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Zhang S; MOE Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Xiong T; MOE Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Xu K; MOE Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Zhou X; MOE Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Gong M; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 100084, China.
Miska E; Wellcome Trust/Cancer Research UK Gurdon Institute, Department of Genetics, University of Cambridge, Cambridge CB2 1QN, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, CB10 1SA, UK.
Ding Q; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 100084, China. Electronic address: .
Wang J; NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Electronic address: .
Zhang QC; MOE Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China. Electronic address: .
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Źródło :
Cell [Cell] 2021 Apr 01; Vol. 184 (7), pp. 1865-1883.e20. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Repositioning*
RNA, Viral*/chemistry
SARS-CoV-2*/drug effects
SARS-CoV-2*/genetics
COVID-19/*drug therapy
RNA-Binding Proteins/*antagonists & inhibitors
Animals ; Cell Line ; Chlorocebus aethiops ; Deep Learning ; Humans ; Nucleic Acid Conformation ; RNA-Binding Proteins/metabolism
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm.
Autorzy :
Verma AK; Cell and Biochemical Technology Laboratory, Department of Zoology, Cotton University, Guwahati, India.
Aggarwal R; Cosmic Cordycep Farms, Badarpur Said Tehsil Tigaon, Faridabad, Haryana, India.
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Źródło :
Chemical biology & drug design [Chem Biol Drug Des] 2021 Apr; Vol. 97 (4), pp. 836-853. Date of Electronic Publication: 2020 Dec 22.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
Machine Learning*
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Binding Sites ; COVID-19/pathology ; COVID-19/virology ; Cell Line ; Cell Survival/drug effects ; Deoxyadenosines/chemistry ; Deoxyadenosines/metabolism ; Humans ; Molecular Docking Simulation ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/metabolism ; Structure-Activity Relationship ; Viral Matrix Proteins/antagonists & inhibitors ; Viral Matrix Proteins/metabolism
Czasopismo naukowe
Tytuł :
Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients.
Autorzy :
Yao X; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.
Yan X; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, 999077, China.
Wang X; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Cai T; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Zhang S; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Cui C; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.
Wang X; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Hou Z; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Liu Q; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, China.
Li H; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, 100191, China.
Lin J; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Xiong Z; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Liu D; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China. .
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Źródło :
European journal of clinical pharmacology [Eur J Clin Pharmacol] 2021 Apr; Vol. 77 (4), pp. 583-593. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Drug Repositioning*
Models, Biological*
COVID-19/*drug therapy
Chloroquine/*analogs & derivatives
Administration, Oral ; Adult ; Aged ; COVID-19/virology ; Chloroquine/administration & dosage ; Chloroquine/adverse effects ; Chloroquine/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Gastrointestinal Absorption ; Humans ; Male ; Metabolic Clearance Rate ; Middle Aged ; SARS-CoV-2/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Repurposing of some anti-infective drugs for COVID-19 treatment: A surveillance study supported by an in silico investigation.
Autorzy :
Sayed AM; Pharmacognosy Department, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.
Khalaf AM; Internal Medicine Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Abdelrahim MEA; Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Elgendy MO; Clinical Pharmacy Department, Teaching Hospital of Faculty of Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.; Clinical Pharmacy Department, Faculty of Pharmacy, Nahda University (NUB), Egypt.
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Źródło :
International journal of clinical practice [Int J Clin Pract] 2021 Apr; Vol. 75 (4), pp. e13877. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*/drug therapy
Drug Repositioning*
Pharmaceutical Preparations*
Adolescent ; Computer Simulation ; Female ; Humans ; Lactation ; Male ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.
Autorzy :
Rajoli RKR; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Pertinez H; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Arshad U; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Box H; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Tatham L; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Curley P; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Neary M; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Sharp J; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Liptrott NJ; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Valentijn A; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
David C; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Rannard SP; Department of Chemistry, University of Liverpool, Liverpool, UK.
Aljayyoussi G; Centre for Drugs and Diagnostics, and Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Pennington SH; Centre for Drugs and Diagnostics, and Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Hill A; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Boffito M; Chelsea and Westminster NHS Foundation Trust and St Stephen's AIDS Trust 4th Floor, Chelsea and Westminster Hospital, London, UK.; Jefferiss Research Trust Laboratories, Department of Medicine, Imperial College, London, UK.
Ward SA; Centre for Drugs and Diagnostics, and Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Khoo SH; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Bray PG; Pat Bray Electrical, Orrell, Wigan, UK.
O'Neill PM; Department of Chemistry, University of Liverpool, Liverpool, UK.
Hong WD; Department of Chemistry, University of Liverpool, Liverpool, UK.
Biagini GA; Centre for Drugs and Diagnostics, and Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Owen A; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
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Źródło :
British journal of clinical pharmacology [Br J Clin Pharmacol] 2021 Apr; Vol. 87 (4), pp. 2078-2088. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Drug Repositioning*
Models, Biological*
Antiviral Agents/*administration & dosage
COVID-19/*drug therapy
COVID-19/*prevention & control
Nitro Compounds/*administration & dosage
Thiazoles/*administration & dosage
Adult ; Antiviral Agents/blood ; Antiviral Agents/pharmacokinetics ; COVID-19/blood ; Computer Simulation ; Drug Dosage Calculations ; Female ; Humans ; Lung/metabolism ; Male ; Middle Aged ; Nitro Compounds/blood ; Nitro Compounds/pharmacokinetics ; Reproducibility of Results ; Thiazoles/blood ; Thiazoles/pharmacokinetics ; Tissue Distribution ; Young Adult
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Repurposing approved drugs for cancer therapy.
Autorzy :
Schein CH; Department of Biochemistry and Molecular Biology Faculty, Institute for Human Infections and Immunity (IHII), University of Texas Medical Branch, Galveston 301 University Boulevard, Galveston, Texas 77555, USA.
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Źródło :
British medical bulletin [Br Med Bull] 2021 Mar 25; Vol. 137 (1), pp. 13-27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Drug Repositioning*
COVID-19/*drug therapy
Neoplasms/*drug therapy
Humans
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
SAveRUNNER: an R-based tool for drug repurposing.
Autorzy :
Fiscon G; Institute for Systems Analysis and Computer Science, Antonio Ruberti', National Research Council, Rome, Italy.; Fondazione Per La Medicina Personalizzata, Via Goffredo Mameli, 3/1, Genoa, Italy.
Paci P; Institute for Systems Analysis and Computer Science, Antonio Ruberti', National Research Council, Rome, Italy. .; Department of Computer, Control and Management Engineering, Sapienza University of Rome, Rome, Italy. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Mar 23; Vol. 22 (1), pp. 150. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
Software*
Antiviral Agents/*pharmacology
SARS-CoV-2/*drug effects
COVID-19 ; Humans ; Off-Label Use
Czasopismo naukowe
Tytuł :
Data science in unveiling COVID-19 pathogenesis and diagnosis: evolutionary origin to drug repurposing.
Autorzy :
Kumar Das J; Department of Pediatrics, School of Medicine, Johns Hopkins University, Maryland, USA.
Tradigo G; eCampus University, Via Isimbardi 10, 22060 Novedrate, CO, Italy.
Veltri P; Department of Surgical and Medical Sciences, Magna Graecia University, Catanzaro, 88100, Italy.
H Guzzi P; Department of Surgical and Medical Sciences, Magna Graecia University, Catanzaro, 88100, Italy.
Roy S; Network Reconstruction & Analysis (NetRA) Lab, Department of Computer Applications, Sikkim University, Gangtok, India.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Mar 22; Vol. 22 (2), pp. 855-872.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Data Science*
Drug Repositioning*
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
COVID-19/pathology ; COVID-19/virology ; Humans ; SARS-CoV-2/isolation & purification
Czasopismo naukowe
Tytuł :
DrugRepV: a compendium of repurposed drugs and chemicals targeting epidemic and pandemic viruses.
Autorzy :
Rajput A; Virology Unit and Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh-160036, India.
Kumar A; Virology Unit and Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh-160036, India.
Megha K; Virology Unit and Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh-160036, India.
Thakur A; Virology Unit and Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh-160036, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
Kumar M; Virology Unit and Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh-160036, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Mar 22; Vol. 22 (2), pp. 1076-1084.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Repositioning*
Pandemics*
Antiviral Agents/*pharmacology
COVID-19/virology ; Databases, Factual ; Humans ; SARS-CoV-2/drug effects
Czasopismo naukowe
Tytuł :
Drug repurposing for COVID-19: could vitamin C combined with glycyrrhizic acid be at play by the findings of Li et al.'s database-based network pharmacology analysis?
Autorzy :
Huang YX; Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi'an, P.R. China.
Wang WX; Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi'an, P.R. China.
Tang YP; Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi'an, P.R. China.
Yue SJ; Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi'an, P.R. China.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Mar 22; Vol. 22 (2), pp. 1508-1510.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Databases, Pharmaceutical*
Drug Repositioning*
Ascorbic Acid/*therapeutic use
COVID-19/*drug therapy
Glycyrrhizic Acid/*therapeutic use
Ascorbic Acid/administration & dosage ; COVID-19/virology ; Glycyrrhizic Acid/administration & dosage ; Humans ; SARS-CoV-2/isolation & purification
Czasopismo naukowe
Tytuł :
A comprehensive drug repurposing study for COVID19 treatment: novel putative dihydroorotate dehydrogenase inhibitors show association to serotonin-dopamine receptors.
Autorzy :
Berber B; Eskisehir Technical University, Department of Biology.
Doluca O; Massey University, New Zealand.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Mar 22; Vol. 22 (2), pp. 1023-1037.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
Antiviral Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors
Receptors, Dopamine/*drug effects
Receptors, Serotonin/*drug effects
COVID-19/drug therapy ; Computer Simulation ; Humans ; Molecular Docking Simulation ; Oxidoreductases Acting on CH-CH Group Donors/chemistry ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
A review on drug repurposing applicable to COVID-19.
Autorzy :
Dotolo S; University of Salerno.
Marabotti A; University of Salerno.
Facchiano A; Institute of Food Sciences, CNR Italy.
Tagliaferri R; Artificial Intelligence, Statistical Pattern Recognition, Clustering, Biomedical imaging and Bioinformatics.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Mar 22; Vol. 22 (2), pp. 726-741.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Repositioning*
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
SARS-CoV-2/*isolation & purification
COVID-19/virology ; Humans ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł :
Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysis.
Autorzy :
Adhami M; Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Sadeghi B; Food Hygiene and Public Health Department, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Rezapour A; Department of Agriculture, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Haghdoost AA; Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
MotieGhader H; Department of Basic sciences, Biotechnology Research Center, Tabriz Branch, Islamic Azad University, Tabriz, Iran. .; Department of Computer Engineering, Gowgan Educational Center, Tabriz Branch, Islamic Azad University, Tabriz, Iran. .
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Źródło :
BMC biotechnology [BMC Biotechnol] 2021 Mar 12; Vol. 21 (1), pp. 22. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
Protein Interaction Maps*
Antiviral Agents/*pharmacology
SARS-CoV-2/*drug effects
COVID-19/drug therapy ; Computational Biology ; Drug Discovery ; Humans ; MicroRNAs
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Lack of Effectiveness of Repurposed Drugs for COVID-19 Treatment.
Autorzy :
Martinez MA; IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Mar 11; Vol. 12, pp. 635371. Date of Electronic Publication: 2021 Mar 11 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
SARS-CoV-2/*drug effects
Antiviral Agents/adverse effects ; COVID-19/diagnosis ; COVID-19/virology ; Host-Pathogen Interactions ; Humans ; SARS-CoV-2/pathogenicity ; Treatment Outcome
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe

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