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Wyszukujesz frazę ""Drug Repositioning"" wg kryterium: Temat


Tytuł:
Genomic and computational-aided integrative drug repositioning strategy for EGFR and ROS1 mutated NSCLC.
Autorzy:
Tripathi V; Department of Biochemistry, Dr. Ram Manohar Lohia Avadh University Ayodhya, Uttar Pradesh, India.
Khare A; Department of Biochemistry, Dr. Ram Manohar Lohia Avadh University Ayodhya, Uttar Pradesh, India.
Shukla D; Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Computational Chemistry & Drug Discovery Division, Quanta Calculus, Greater Noida, India. Electronic address: .
Bharadwaj S; Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Průmyslová 595, 252 50 Vestec, Czech Republic. Electronic address: .
Kirtipal N; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea. Electronic address: .
Ranjan V; Department of Biochemistry, Dr. Ram Manohar Lohia Avadh University Ayodhya, Uttar Pradesh, India. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112682. Date of Electronic Publication: 2024 Jul 18.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Lung Neoplasms*/genetics
Lung Neoplasms*/drug therapy
ErbB Receptors*/genetics
ErbB Receptors*/antagonists & inhibitors
Protein-Tyrosine Kinases*/genetics
Protein-Tyrosine Kinases*/antagonists & inhibitors
Mutation*
Proto-Oncogene Proteins*/genetics
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Humans ; Molecular Docking Simulation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Genomics/methods
Czasopismo naukowe
Tytuł:
Repositioning fluphenazine as a cuproptosis-dependent anti-breast cancer drug candidate based on TCGA database.
Autorzy:
Zhang X; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan 030001, China; Department of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Shi X; Department of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Zhang X; Department of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Zhang Y; Department of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Yu S; Department of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Zhang Y; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan 030001, China; Department of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China; School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China; Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan 030001, China. Electronic address: .
Liu Y; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan 030001, China. Electronic address: .
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Źródło:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Sep; Vol. 178, pp. 117293. Date of Electronic Publication: 2024 Aug 13.
Typ publikacji:
Journal Article
MeSH Terms:
Fluphenazine*/pharmacology
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Breast Neoplasms*/pathology
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Drug Repositioning*/methods
Cell Survival*/drug effects
Humans ; Female ; MCF-7 Cells ; Copper ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects ; Databases, Genetic
Czasopismo naukowe
Tytuł:
Discovery of a Therapeutic Agent for Glioblastoma Using a Systems Biology-Based Drug Repositioning Approach.
Autorzy:
Kaynar A; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London SE1 9RT, UK.
Ozcan M; Science for Life Laboratory, KTH-Royal Institute of Technology, SE-17121 Stockholm, Sweden.; Department of Medical Biochemistry, Faculty of Medicine, Zonguldak Bülent Ecevit University, Zongudak TR-67100, Turkey.
Li X; Science for Life Laboratory, KTH-Royal Institute of Technology, SE-17121 Stockholm, Sweden.
Turkez H; Medical Biology Department, Faculty of Medicine, Atatürk University, Erzurum TR-25240, Turkey.
Zhang C; Science for Life Laboratory, KTH-Royal Institute of Technology, SE-17121 Stockholm, Sweden.
Uhlén M; Science for Life Laboratory, KTH-Royal Institute of Technology, SE-17121 Stockholm, Sweden.
Shoaie S; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London SE1 9RT, UK.
Mardinoglu A; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London SE1 9RT, UK.; Science for Life Laboratory, KTH-Royal Institute of Technology, SE-17121 Stockholm, Sweden.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jul 18; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 18.
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/drug therapy
Glioblastoma*/metabolism
Glioblastoma*/pathology
Glioblastoma*/genetics
Drug Repositioning*/methods
Systems Biology*/methods
Humans ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; ErbB Receptors/metabolism ; ErbB Receptors/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Receptor, ErbB-2/metabolism ; Receptor, ErbB-2/genetics ; Cell Survival/drug effects ; Drug Discovery/methods
Czasopismo naukowe
Tytuł:
Potential for Drug Repositioning of Midazolam as an Inhibitor of Inflammatory Bone Resorption.
Autorzy:
Harigaya H; Department of Dental Anesthesiology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.
Chiba-Ohkuma R; Department of Biochemistry and Molecular Biology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.
Karakida T; Department of Biochemistry and Molecular Biology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.
Yamamoto R; Department of Biochemistry and Molecular Biology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.
Fujii-Abe K; Department of Dental Anesthesiology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.
Kawahara H; Department of Dental Anesthesiology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.
Yamakoshi Y; Department of Biochemistry and Molecular Biology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jul 12; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 12.
Typ publikacji:
Journal Article
MeSH Terms:
Bone Resorption*/drug therapy
Drug Repositioning*/methods
Midazolam*/pharmacology
Reactive Oxygen Species*/metabolism
Osteoclasts*/drug effects
Osteoclasts*/metabolism
Cell Differentiation*/drug effects
Lipopolysaccharides*/pharmacology
Animals ; Mice ; p38 Mitogen-Activated Protein Kinases/metabolism ; Male ; Inflammation/drug therapy ; Inflammation/pathology ; RAW 264.7 Cells ; Macrophages/drug effects ; Macrophages/metabolism
Czasopismo naukowe
Tytuł:
Antiretroviral Drugs Impact Autophagy: Opportunities for Drug Repurposing.
Autorzy:
Cheney L; Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA.; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Barbaro JM; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
McDermott G; Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Berman JW; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
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Źródło:
Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2024 Jul 02; Vol. 29 (7), pp. 242.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Autophagy*/drug effects
Drug Repositioning*/methods
Neoplasms*/drug therapy
Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; Anti-Retroviral Agents/pharmacology ; HIV Infections/drug therapy ; Animals
Czasopismo naukowe
Tytuł:
Repurposing ezetimibe as a neuroprotective agent in a rotenone-induced Parkinson's disease model in rats: Role of AMPK/SIRT-1/PGC-1α signaling and autophagy.
Autorzy:
Elesawy WH; Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), 6 October, Egypt.
El-Sahar AE; Biology Department, School of Pharmacy, Newgiza University, Giza, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Sayed RH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: .
Ashour AM; Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al Qura University, P.O. Box 13578, Makkah 21955, Saudi Arabia.
Alsufyani SE; Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Arab HH; Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia. Electronic address: .
Kandil EA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 10; Vol. 138, pp. 112640. Date of Electronic Publication: 2024 Jul 08.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Ezetimibe*/pharmacology
Neuroprotective Agents*/pharmacology
Parkinson Disease*/drug therapy
Parkinson Disease*/metabolism
Signal Transduction*/drug effects
Animals ; Male ; Rats ; AMP-Activated Protein Kinases/metabolism ; Autophagy/drug effects ; Disease Models, Animal ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Rats, Wistar ; Rotenone ; Sirtuin 1/metabolism
Czasopismo naukowe
Tytuł:
Repurposing of antimycobacterium drugs for COVID-19 treatment by targeting SARS CoV-2 main protease: An in-silico perspective.
Autorzy:
Chakraborty A; University Institute of Biotechnology, University Centre for Research & Development, Chandigarh University, Mohali, India.
Ghosh R; School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, India.
Soumya Mohapatra S; School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, India.
Barik S; School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, India.
Biswas A; School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, India. Electronic address: .
Chowdhuri S; School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, India. Electronic address: .
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Źródło:
Gene [Gene] 2024 Sep 05; Vol. 922, pp. 148553. Date of Electronic Publication: 2024 May 10.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Molecular Docking Simulation*
COVID-19 Drug Treatment*
SARS-CoV-2*/drug effects
SARS-CoV-2*/enzymology
Coronavirus 3C Proteases*/antagonists & inhibitors
Coronavirus 3C Proteases*/metabolism
Coronavirus 3C Proteases*/chemistry
Molecular Dynamics Simulation*
Humans ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Minocycline/pharmacology ; Rifampin/pharmacology ; COVID-19/virology ; Computer Simulation
Czasopismo naukowe
Tytuł:
Repurposing of a library for high-content screening of inhibitors against Echinococcus granulosus.
Autorzy:
Zheng W; Department of Disease Biology, Global Health Drug Discovery Institute, Beijing, 100000, China. .
Lv G; Department of Disease Biology, Global Health Drug Discovery Institute, Beijing, 100000, China.
Li J; State Key Laboratory Incubation Base of Xinjiang Major Diseases Research, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Zhang Y; State Key Laboratory Incubation Base of Xinjiang Major Diseases Research, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Qi W; State Key Laboratory Incubation Base of Xinjiang Major Diseases Research, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Yan M; State Key Laboratory Incubation Base of Xinjiang Major Diseases Research, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Wu J; Department of Disease Biology, Global Health Drug Discovery Institute, Beijing, 100000, China.
Chan C; Department of Disease Biology, Global Health Drug Discovery Institute, Beijing, 100000, China.
Pan X; Department of Disease Biology, Global Health Drug Discovery Institute, Beijing, 100000, China. .
Zhang W; State Key Laboratory Incubation Base of Xinjiang Major Diseases Research, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China. .
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Źródło:
Parasites & vectors [Parasit Vectors] 2024 Sep 03; Vol. 17 (1), pp. 373. Date of Electronic Publication: 2024 Sep 03.
Typ publikacji:
Journal Article
MeSH Terms:
Echinococcus granulosus*/drug effects
High-Throughput Screening Assays*/methods
Drug Repositioning*
Echinococcosis*/drug therapy
Echinococcosis*/parasitology
Animals ; Mice ; Small Molecule Libraries/pharmacology ; Drug Evaluation, Preclinical ; Anthelmintics/pharmacology ; Drug Discovery ; Dogs
Czasopismo naukowe
Tytuł:
Identification of critical genes and metabolic pathways in rheumatoid arthritis and osteoporosis toward drug repurposing.
Autorzy:
Ziaastani Z; Faculty of Mathematics and Computer Science, Department of Bioinformatics, Bahonar University, Kerman, Iran; Bahonar Bioinformatics Lab (BBL), Iran.
Kalantari-Khandani B; Department of Oncology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Niazi MJ; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran; Bahonar Bioinformatics Lab (BBL), Iran.
Kazemipour A; Faculty of Mathematics and Computer Science, Department of Bioinformatics, Bahonar University, Kerman, Iran; Bahonar Bioinformatics Lab (BBL), Iran. Electronic address: .
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Źródło:
Computers in biology and medicine [Comput Biol Med] 2024 Sep; Vol. 180, pp. 108912. Date of Electronic Publication: 2024 Jul 29.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*/methods
Arthritis, Rheumatoid*/drug therapy
Arthritis, Rheumatoid*/genetics
Arthritis, Rheumatoid*/metabolism
Osteoporosis*/drug therapy
Osteoporosis*/genetics
Osteoporosis*/metabolism
Humans ; Metabolic Networks and Pathways/genetics ; Metabolic Networks and Pathways/drug effects ; Protein Interaction Maps/genetics ; Gene Regulatory Networks/drug effects ; Computational Biology/methods
Czasopismo naukowe
Tytuł:
Computational and biological approaches in repurposing ribavirin for lung cancer treatment: Unveiling antitumorigenic strategies.
Autorzy:
Paudel KR; Centre of Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW 2007, Australia.
Singh M; Department of Biotechnology, Jaypee Institute of Information Technology (JIIT), Noida, Uttar Pradesh, India; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
De Rubis G; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Kumbhar P; Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Tal: Panhala, Dist: Kolhapur, Maharashtra 416113, India.
Mehndiratta S; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Kokkinis S; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
El-Sherkawi T; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Gupta G; Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India; Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates.
Singh SK; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia; School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi GT Road, Phagwara 144411, Punjab, India.
Malik MZ; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman, Kuwait city 15462, Kuwait.
Mohammed Y; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.
Oliver BG; Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia; School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Disouza J; Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Tal: Panhala, Dist: Kolhapur, Maharashtra 416113, India.
Patravale V; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai 400019, Maharashtra, India.
Hansbro PM; Centre of Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW 2007, Australia. Electronic address: .
Dua K; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2024 Sep 01; Vol. 352, pp. 122859. Date of Electronic Publication: 2024 Jun 25.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*/methods
Lung Neoplasms*/drug therapy
Lung Neoplasms*/pathology
Ribavirin*/pharmacology
Cell Proliferation*/drug effects
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Humans ; A549 Cells ; Cell Movement/drug effects ; Apoptosis/drug effects ; Molecular Docking Simulation ; Antiviral Agents/pharmacology ; Computational Biology/methods ; Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/metabolism
Czasopismo naukowe
Tytuł:
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies.
Autorzy:
Das V; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.; Czech Advanced Technologies and Research Institute (CATRIN), Institute of Molecular and Translational Medicine, Palacký University Olomouc, Olomouc, Czech Republic.
Miller JH; School of Biological Sciences and Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand.
Alladi CG; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.
Annadurai N; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.
De Sanctis JB; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.; Czech Advanced Technologies and Research Institute (CATRIN), Institute of Molecular and Translational Medicine, Palacký University Olomouc, Olomouc, Czech Republic.
Hrubá L; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.; Czech Advanced Technologies and Research Institute (CATRIN), Institute of Molecular and Translational Medicine, Palacký University Olomouc, Olomouc, Czech Republic.
Hajdúch M; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic.; Czech Advanced Technologies and Research Institute (CATRIN), Institute of Molecular and Translational Medicine, Palacký University Olomouc, Olomouc, Czech Republic.
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Źródło:
Medicinal research reviews [Med Res Rev] 2024 Sep; Vol. 44 (5), pp. 2078-2111. Date of Electronic Publication: 2024 Mar 26.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/drug therapy
Dementia*/drug therapy
Drug Repositioning*
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Antineoplastic Agents*/chemistry
Humans ; Animals ; Observational Studies as Topic ; Drug Evaluation, Preclinical
Czasopismo naukowe
Tytuł:
Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs).
Autorzy:
Haupenthal J; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Saarland University, Saarbrücken, Germany.
Rafehi M; Institute of Clinical Pharmacology, University Medical Center Göttingen, Göttingen, Germany.; Department of Medical Education Augsburg, Augsburg University Medicine, Augsburg, Germany.
Kany AM; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Saarland University, Saarbrücken, Germany.
Lespine A; INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France.
Stefan K; Lübeck Institute of Experimental Dermatology, Medicinal Chemistry and Systems Polypharmacology, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.
Hirsch AKH; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Saarland University, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany.
Stefan SM; Lübeck Institute of Experimental Dermatology, Medicinal Chemistry and Systems Polypharmacology, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.; Department of Biopharmacy, Medical University of Lublin, Lublin, Poland.
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Źródło:
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Sep; Vol. 357 (9), pp. e2400267. Date of Electronic Publication: 2024 Jun 19.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Bacterial Agents*/pharmacology
Anti-Bacterial Agents*/chemistry
Anti-Bacterial Agents*/chemical synthesis
Drug Repositioning*
Ivermectin*/pharmacology
Ivermectin*/analogs & derivatives
Ivermectin*/chemistry
Ivermectin*/chemical synthesis
Microbial Sensitivity Tests*
Humans ; Structure-Activity Relationship ; ATP-Binding Cassette Transporters/antagonists & inhibitors ; ATP-Binding Cassette Transporters/metabolism ; Streptococcus pneumoniae/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug
Czasopismo naukowe
Tytuł:
Accelerating drug discovery and repurposing by combining transcriptional signature connectivity with docking.
Autorzy:
Thorman AW; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
Reigle J; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.; Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati, Cincinnati, OH, USA.; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Chutipongtanate S; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.; Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Yang J; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.; Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati, Cincinnati, OH, USA.; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Shamsaei B; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Pilarczyk M; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
Fazel-Najafabadi M; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
Adamczak R; Department of Informatics, Faculty of Physics, Astronomy an Informatics, Nicolaus Copernicus University, Toruń, Poland.
Kouril M; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Bhatnagar S; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Computer Science, University of Cincinnati, Cincinnati, OH, USA.
Hummel S; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Niu W; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
Morrow AL; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
Czyzyk-Krzeska MF; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Veterans Affairs, Cincinnati Veteran Affairs Medical Center, Cincinnati, OH, USA.
McCullumsmith R; Department of Neurosciences, University of Toledo, Toledo, OH, USA.
Seibel W; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Nassar N; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Zheng Y; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hildeman DA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Medvedovic M; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.; Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati, Cincinnati, OH, USA.
Herr AB; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Meller J; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.; Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati, Cincinnati, OH, USA.; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Informatics, Faculty of Physics, Astronomy an Informatics, Nicolaus Copernicus University, Toruń, Poland.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Computer Science, University of Cincinnati, Cincinnati, OH, USA.
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Źródło:
Science advances [Sci Adv] 2024 Aug 30; Vol. 10 (35), pp. eadj3010. Date of Electronic Publication: 2024 Aug 30.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Discovery*/methods
Molecular Docking Simulation*
Drug Repositioning*/methods
Humans ; Transcriptome ; Machine Learning ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Identifying potential repurposable medications for Parkinson's disease through Mendelian randomization analysis.
Autorzy:
Wang Q; Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China.
Liu F; Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China.
Wang X; Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China.
Zhong L; Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China.
Cai B; Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China. .
Chen T; Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China. .; Hainan Provincial Bureau of Disease Prevention and Control, Haikou, 570100, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Aug 24; Vol. 14 (1), pp. 19670. Date of Electronic Publication: 2024 Aug 24.
Typ publikacji:
Journal Article; Meta-Analysis
MeSH Terms:
Parkinson Disease*/genetics
Parkinson Disease*/drug therapy
Mendelian Randomization Analysis*
Drug Repositioning*
Humans ; Disease Progression
Czasopismo naukowe
Tytuł:
Repurposing Anidulafungin for Alzheimer's Disease via Fragment-Based Drug Discovery.
Autorzy:
Xie S; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, P. R. China.
Liang Y; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, P. R. China.
Song Y; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, P. R. China.
Li T; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, P. R. China.
Jia J; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, P. R. China.; Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, P. R. China.; Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing 100053, P. R. China.; Center of Alzheimer's Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100053, P. R. China.; Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, P. R. China.
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Źródło:
ACS chemical neuroscience [ACS Chem Neurosci] 2024 Aug 21; Vol. 15 (16), pp. 2995-3008. Date of Electronic Publication: 2024 Aug 03.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Drug Repositioning*/methods
Amyloid beta-Peptides*/metabolism
Drug Discovery*/methods
Anidulafungin*/pharmacology
Humans ; Animals ; Echinocandins/pharmacology ; Echinocandins/chemistry ; Molecular Docking Simulation/methods ; Peptide Fragments/pharmacology ; Peptide Fragments/metabolism
Czasopismo naukowe
Tytuł:
Mechanistic insights into antifungal potential of Alexidine dihydrochloride and hexachlorophene in Candida albicans: a drug repurposing approach.
Autorzy:
Ansari A; Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun, 248001, Uttarakhand, India.
Kumar D; Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun, 248001, Uttarakhand, India.
Gupta P; Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun, 248001, Uttarakhand, India.
Poluri KM; Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India.; Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India.
Rai N; Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun, 248001, Uttarakhand, India.
Ameen F; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Kumar N; Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun, 248001, Uttarakhand, India. .
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Źródło:
Archives of microbiology [Arch Microbiol] 2024 Aug 20; Vol. 206 (9), pp. 383. Date of Electronic Publication: 2024 Aug 20.
Typ publikacji:
Journal Article
MeSH Terms:
Candida albicans*/drug effects
Candida albicans*/genetics
Antifungal Agents*/pharmacology
Drug Repositioning*
Biofilms*/drug effects
Microbial Sensitivity Tests*
Humans ; Amidines/pharmacology ; Hyphae/drug effects ; Hyphae/growth & development ; Ergosterol/metabolism ; Candidiasis/drug therapy ; Candidiasis/microbiology ; Virulence/drug effects ; Biguanides
Czasopismo naukowe
Tytuł:
Drug Repurposing for COVID-19 by Constructing a Comorbidity Network with Central Nervous System Disorders.
Autorzy:
Qian J; MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-Infective Medicine, Department of Bioinformatics, Center for Systems Biology, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou 215213, China.
Yang B; MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-Infective Medicine, Department of Bioinformatics, Center for Systems Biology, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou 215213, China.
Wang S; MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-Infective Medicine, Department of Bioinformatics, Center for Systems Biology, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou 215213, China.
Yuan S; MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-Infective Medicine, Department of Bioinformatics, Center for Systems Biology, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou 215213, China.
Zhu W; MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-Infective Medicine, Department of Bioinformatics, Center for Systems Biology, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou 215213, China.
Zhou Z; MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-Infective Medicine, Department of Bioinformatics, Center for Systems Biology, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou 215213, China.
Zhang Y; Experimental Center of Suzhou Medical College of Soochow University, Suzhou 215123, China.
Hu G; MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-Infective Medicine, Department of Bioinformatics, Center for Systems Biology, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou 215213, China.; Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Soochow University, Suzhou 215123, China.; Key Laboratory of Alkene-Carbon Fibres-Based Technology & Application for Detection of Major Infectious Diseases, Soochow University, Suzhou 215123, China.; Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Aug 16; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 16.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*/methods
COVID-19 Drug Treatment*
SARS-CoV-2*/drug effects
Comorbidity*
COVID-19*/virology
COVID-19*/epidemiology
Central Nervous System Diseases*/drug therapy
Central Nervous System Diseases*/virology
Antiviral Agents*/therapeutic use
Antiviral Agents*/pharmacology
Humans ; Molecular Dynamics Simulation
Czasopismo naukowe
Tytuł:
Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
Autorzy:
Papini N; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, LITA Segrate, 20054 Segrate, MI, Italy.
Giussani P; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, LITA Segrate, 20054 Segrate, MI, Italy.
Tringali C; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, LITA Segrate, 20054 Segrate, MI, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Aug 15; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 15.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Metformin*/pharmacology
Metformin*/therapeutic use
Lysosomes*/metabolism
Lysosomes*/drug effects
Neurodegenerative Diseases*/drug therapy
Neurodegenerative Diseases*/metabolism
Drug Repositioning*/methods
Humans ; Animals ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Autophagy/drug effects
Czasopismo naukowe
Tytuł:
Repurposing approved protein kinase inhibitors as potent anti-leishmanials targeting Leishmania MAP kinases.
Autorzy:
Bhattacharjee A; Cell and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani, Nadia 741235, India.
Bagchi A; Cell and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani, Nadia 741235, India.
Sarkar S; Cell and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani, Nadia 741235, India.
Bawali S; Cell and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani, Nadia 741235, India.
Bhattacharya A; AMR Research Laboratory, Department of Biological Sciences, Adamas University, Kolkata 700126, India. Electronic address: .
Biswas A; Cell and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani, Nadia 741235, India. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2024 Aug 15; Vol. 351, pp. 122844. Date of Electronic Publication: 2024 Jun 17.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Protein Kinase Inhibitors*/pharmacology
Leishmania*/drug effects
Leishmania*/enzymology
Antiprotozoal Agents*/pharmacology
Animals ; Mice ; Reactive Oxygen Species/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Leishmaniasis, Visceral/drug therapy ; Leishmaniasis, Visceral/parasitology ; Mice, Inbred BALB C ; Humans ; Macrophages/parasitology ; Macrophages/drug effects ; Macrophages/metabolism ; Female ; Sorafenib/pharmacology ; Imatinib Mesylate/pharmacology
Czasopismo naukowe
Tytuł:
Identification of HRH1 as an alternative receptor for SARS-CoV-2: insights from viral inhibition by repurposable antihistamines.
Autorzy:
Zhong G; Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China.; Trauma Center, West China Hospital, Sichuan University, Chengdu, China.
Li J; Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Wang H; Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
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Źródło:
MBio [mBio] 2024 Aug 14; Vol. 15 (8), pp. e0169724. Date of Electronic Publication: 2024 Jul 22.
Typ publikacji:
Journal Article; Comment
MeSH Terms:
SARS-CoV-2*/drug effects
Drug Repositioning*
Virus Internalization*/drug effects
Humans ; COVID-19 Drug Treatment ; Histamine Antagonists/pharmacology ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Antiviral Agents/pharmacology ; Receptors, Histamine H1/metabolism ; Receptors, Histamine H1/genetics ; COVID-19/virology ; Receptors, Virus/metabolism
Czasopismo naukowe

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