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Tytuł:
Drug Repositioning via Graph Neural Networks: Identifying Novel JAK2 Inhibitors from FDA-Approved Drugs through Molecular Docking and Biological Validation.
Autorzy:
Yasir M; Department of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Park J; Department of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Han ET; Department of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Park WS; Department of Physiology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Han JH; Department of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Chun W; Department of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Mar 19; Vol. 29 (6). Date of Electronic Publication: 2024 Mar 19.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Artificial Intelligence*
Molecular Docking Simulation ; Reproducibility of Results ; Neural Networks, Computer
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GEFormerDTA: drug target affinity prediction based on transformer graph for early fusion.
Autorzy:
Liu Y; Department of Computer Science and Technology, Shandong University of Technology, Zibo, 255000, China.
Xing L; Department of Computer Science and Technology, Shandong University of Technology, Zibo, 255000, China. .
Zhang L; Department of Computer Science and Technology, Shandong University of Technology, Zibo, 255000, China.
Cai H; Department of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo, 255000, China.
Guo M; Department of Electrical and Information Engineering, Beijing University of Architecture, Beijing, 102616, China.
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 28; Vol. 14 (1), pp. 7416. Date of Electronic Publication: 2024 Mar 28.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Discovery*
Drug Repositioning*
Amino Acid Sequence ; Electric Power Supplies ; Learning
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Single-cell transcriptional signature-based drug repurposing and in vitro evaluation in colorectal cancer.
Autorzy:
Mahdi-Esferizi R; Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Shiasi Z; Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Heidari R; Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Najafi A; Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Mahmoudi I; Information Technology Department, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Elahian F; Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Tahmasebian S; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Mar 25; Vol. 24 (1), pp. 371. Date of Electronic Publication: 2024 Mar 25.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*/methods
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Dicarboxylic Acids*
Fatty Acids*
Humans ; HT29 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Exploring NCATS in-house biomedical data for evidence-based drug repurposing.
Autorzy:
Liu F; Division of Rare Diseases Research Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
Patt A; Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland, United States of America.
Chen C; Division of Rare Diseases Research Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
Huang R; Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland, United States of America.
Xu Y; Division of Rare Diseases Research Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
Mathé EA; Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland, United States of America.
Zhu Q; Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland, United States of America.
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Źródło:
PloS one [PLoS One] 2024 Jan 25; Vol. 19 (1), pp. e0289518. Date of Electronic Publication: 2024 Jan 25 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
National Center for Advancing Translational Sciences (U.S.)*
United States ; Translational Science, Biomedical
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Special Issue: "Drug Repurposing for Cancer Therapies".
Autorzy:
Xavier CPR; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.; Cancer Drug Resistance Group, IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Palmeira A; LQOF-Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leixões, 4450-208 Matosinhos, Portugal.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 16; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 16.
Typ publikacji:
Editorial
MeSH Terms:
Drug Repositioning*
Neoplasms*/drug therapy
Humans
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identifying patterns to uncover the importance of biological pathways on known drug repurposing scenarios.
Autorzy:
Otero-Carrasco B; Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223, Spain.; ETS Ingenieros Informáticos, Universidad Politécnica de Madrid, Boadilla del Monte, 28660, Spain.
Ugarte Carro E; Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223, Spain.
Prieto-Santamaría L; Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223, Spain.; ETS Ingenieros Informáticos, Universidad Politécnica de Madrid, Boadilla del Monte, 28660, Spain.
Diaz Uzquiano M; Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223, Spain.
Caraça-Valente Hernández JP; ETS Ingenieros Informáticos, Universidad Politécnica de Madrid, Boadilla del Monte, 28660, Spain.
Rodríguez-González A; Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223, Spain. .; ETS Ingenieros Informáticos, Universidad Politécnica de Madrid, Boadilla del Monte, 28660, Spain. .
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Źródło:
BMC genomics [BMC Genomics] 2024 Jan 09; Vol. 25 (1), pp. 43. Date of Electronic Publication: 2024 Jan 09.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Lipid Metabolism*
Drug Delivery Systems ; Statistics, Nonparametric
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anti-Dengue: A Machine Learning-Assisted Prediction of Small Molecule Antivirals against Dengue Virus and Implications in Drug Repurposing.
Autorzy:
Gautam S; Virology Unit, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh 160036, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Thakur A; Virology Unit, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh 160036, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Rajput A; Virology Unit, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh 160036, India.
Kumar M; Virology Unit, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh 160036, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
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Źródło:
Viruses [Viruses] 2023 Dec 27; Vol. 16 (1). Date of Electronic Publication: 2023 Dec 27.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Dengue Virus*
Reproducibility of Results ; Machine Learning ; Antiviral Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A novel efficient drug repurposing framework through drug-disease association data integration using convolutional neural networks.
Autorzy:
Amiri R; Department of Computer Science, Faculty of Mathematics, Statistics and Computer Science, University of Tabriz, Tabriz, Iran.
Razmara J; Department of Computer Science, Faculty of Mathematics, Statistics and Computer Science, University of Tabriz, Tabriz, Iran. .
Parvizpour S; Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Izadkhah H; Department of Computer Science, Faculty of Mathematics, Statistics and Computer Science, University of Tabriz, Tabriz, Iran.
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2023 Nov 22; Vol. 24 (1), pp. 442. Date of Electronic Publication: 2023 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Neural Networks, Computer*
Drug Discovery
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Trends and Applications in Computationally Driven Drug Repurposing.
Autorzy:
Pinzi L; Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125 Modena, Italy.
Rastelli G; Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125 Modena, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 20; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 20.
Typ publikacji:
Editorial
MeSH Terms:
Drug Repositioning*
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A novel in silico scaffold-hopping method for drug repositioning in rare and intractable diseases.
Autorzy:
Tanabe M; Laboratory of Rare Disease Information and Resource Library, Center for Intractable Diseases and ImmunoGenomics Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, Japan.
Sakate R; Laboratory of Rare Disease Information and Resource Library, Center for Intractable Diseases and ImmunoGenomics Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, Japan.
Nakabayashi J; Analysis Technology Center, FUJIFILM Corporation, 210 Nakanuma, Minami-ashigara, Kanagawa, Japan.
Tsumura K; Analysis Technology Center, FUJIFILM Corporation, 210 Nakanuma, Minami-ashigara, Kanagawa, Japan.
Ohira S; Analysis Technology Center, FUJIFILM Corporation, 210 Nakanuma, Minami-ashigara, Kanagawa, Japan.
Iwato K; Analysis Technology Center, FUJIFILM Corporation, 210 Nakanuma, Minami-ashigara, Kanagawa, Japan.
Kimura T; Reverse Translational Research Project, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki-City, Osaka, Japan. .; KAGAMI Project, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, Japan. .; Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 08; Vol. 13 (1), pp. 19358. Date of Electronic Publication: 2023 Nov 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Repositioning*
Drug Development*
Amino Acids ; Protein Kinase Inhibitors ; Spleen
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
DrugRep-HeSiaGraph: when heterogenous siamese neural network meets knowledge graphs for drug repurposing.
Autorzy:
Ghorbanali Z; Computational Biology Research Center (CBRC), Department of Mathematics and Computer Science, Amirkabir University of Technology, Tehran, Iran.
Zare-Mirakabad F; Computational Biology Research Center (CBRC), Department of Mathematics and Computer Science, Amirkabir University of Technology, Tehran, Iran. .
Salehi N; School of Biological Science, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
Akbari M; Computational Biology Research Center (CBRC), Department of Mathematics and Computer Science, Amirkabir University of Technology, Tehran, Iran.
Masoudi-Nejad A; Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2023 Oct 03; Vol. 24 (1), pp. 374. Date of Electronic Publication: 2023 Oct 03.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
COVID-19*
Humans ; Pattern Recognition, Automated ; SARS-CoV-2 ; Neural Networks, Computer
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Repurposing Drugs for Inhibition against ALDH2 via a 2D/3D Ligand-Based Similarity Search and Molecular Simulation.
Autorzy:
Jiang W; Department of Biological Science and Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing100083, China.
Chen J; Department of Biological Science and Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing100083, China.
Zhang P; Department of Biological Science and Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing100083, China.
Zheng N; Department of Biological Science and Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing100083, China.
Ma L; Department of Biological Science and Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing100083, China.
Zhang Y; Department of Biological Science and Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing100083, China.
Zhang H; Department of Biological Science and Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing100083, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Oct 29; Vol. 28 (21). Date of Electronic Publication: 2023 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Molecular Dynamics Simulation*
Molecular Docking Simulation ; Ligands ; Zeaxanthins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Computational prognostic evaluation of Alzheimer's drugs from FDA-approved database through structural conformational dynamics and drug repositioning approaches.
Autorzy:
Hassan M; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, 43205, USA. .
Shahzadi S; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, 43205, USA.
Yasir M; Department of Pharmacology, College of Medicine, Kangwon National University, Chuncheon, South Korea.
Chun W; Department of Pharmacology, College of Medicine, Kangwon National University, Chuncheon, South Korea.
Kloczkowski A; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, 43205, USA. .; Department of Pediatrics, The Ohio State University, Columbus, OH, 43205, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 21; Vol. 13 (1), pp. 18022. Date of Electronic Publication: 2023 Oct 21.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Repositioning*
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Humans ; Molecular Docking Simulation ; Prognosis ; Astemizole ; Tubocurarine/therapeutic use ; Molecular Dynamics Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Drug repurposing: a nexus of innovation, science, and potential.
Autorzy:
De Rosa MC; Institute of Chemical Sciences and Technologies 'Giulio Natta' (SCITEC) - CNR, L.go F. Vito 1, 00168, Rome, Italy. .
Purohit R; Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, HP, 176061, India. .; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. .
García-Sosa AT; Department of Molecular Technology, Institute of Chemistry, University of Tartu, Ravila 14a, 50411, Tartu, Estonia. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 19; Vol. 13 (1), pp. 17887. Date of Electronic Publication: 2023 Oct 19.
Typ publikacji:
Editorial; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Repositioning*
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unlocking potential inhibitors for Bruton's tyrosine kinase through in-silico drug repurposing strategies.
Autorzy:
Alrouji M; Department of Medical Laboratories, College of Applied Medical Sciences, Shaqra University, 11961, Shaqra, Saudi Arabia.
Benjamin LS; College of Nursing, King Khalid University (KKU), Abha, Kingdom of Saudi Arabia.
Alhumaydhi FA; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, 52571, Buraydah, Saudi Arabia.
Al Abdulmonem W; Department of Pathology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Baeesa SS; Division of Neurosurgery, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Rehan M; King Fahd Medical Research Center, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Shahwan M; College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE.; Center for Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE.
Shamsi A; Center for Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE. .
Akhtar A; Department of Pharmacognosy, College of Pharmacy, King Khalid University (KKU), Guraiger St., 62529, Abha, Saudi Arabia. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 17; Vol. 13 (1), pp. 17684. Date of Electronic Publication: 2023 Oct 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors
Drug Repositioning*
Molecular Dynamics Simulation*
Protein Kinase Inhibitors*/therapeutic use
Humans ; Drug Discovery ; Molecular Docking Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Proteomic meta-study harmonization, mechanotyping and drug repurposing candidate prediction with ProHarMeD.
Autorzy:
Adamowicz K; Institute for Computational Systems Biology, University of Hamburg, Hamburg, 22607, Germany.
Arend L; Institute for Computational Systems Biology, University of Hamburg, Hamburg, 22607, Germany.
Maier A; Institute for Computational Systems Biology, University of Hamburg, Hamburg, 22607, Germany.
Schmidt JR; Department of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.
Kuster B; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Tsoy O; Institute for Computational Systems Biology, University of Hamburg, Hamburg, 22607, Germany.
Zolotareva O; Institute for Computational Systems Biology, University of Hamburg, Hamburg, 22607, Germany.; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
Baumbach J; Institute for Computational Systems Biology, University of Hamburg, Hamburg, 22607, Germany.; Department of Mathematics and Computer Science, University of Southern Denmark, Odense, 5230, Denmark.
Laske T; Institute for Computational Systems Biology, University of Hamburg, Hamburg, 22607, Germany. .
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Źródło:
NPJ systems biology and applications [NPJ Syst Biol Appl] 2023 Oct 10; Vol. 9 (1), pp. 49. Date of Electronic Publication: 2023 Oct 10.
Typ publikacji:
Journal Article
MeSH Terms:
Proteomics*/methods
Drug Repositioning*
Proteins ; Biomarkers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A drug repurposing screen for whipworms informed by comparative genomics.
Autorzy:
Coghlan A; Wellcome Sanger Institute, Cambridge, United Kingdom.
Partridge FA; University College London, London, United Kingdom.; School of Life Sciences, University of Westminster, London, United Kingdom.
Duque-Correa MA; Wellcome Sanger Institute, Cambridge, United Kingdom.
Rinaldi G; Wellcome Sanger Institute, Cambridge, United Kingdom.
Clare S; Wellcome Sanger Institute, Cambridge, United Kingdom.
Seymour L; Wellcome Sanger Institute, Cambridge, United Kingdom.
Brandt C; Wellcome Sanger Institute, Cambridge, United Kingdom.
Mkandawire TT; Wellcome Sanger Institute, Cambridge, United Kingdom.
McCarthy C; Wellcome Sanger Institute, Cambridge, United Kingdom.
Holroyd N; Wellcome Sanger Institute, Cambridge, United Kingdom.
Nick M; University College London, London, United Kingdom.
Brown AE; University College London, London, United Kingdom.
Tonitiwong S; University College London, London, United Kingdom.
Sattelle DB; University College London, London, United Kingdom.
Berriman M; Wellcome Sanger Institute, Cambridge, United Kingdom.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Sep 05; Vol. 17 (9), pp. e0011205. Date of Electronic Publication: 2023 Sep 05 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Repositioning*
Trichuris*/genetics
Adult ; Humans ; Animals ; Mice ; Genomics ; Albendazole/pharmacology ; Biological Transport
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
VGAEDTI: drug-target interaction prediction based on variational inference and graph autoencoder.
Autorzy:
Zhang Y; Yinfei Feng Qingdao University of Technology, Qingdao, China.
Feng Y; Yinfei Feng Qingdao University of Technology, Qingdao, China. .
Wu M; Yinfei Feng Qingdao University of Technology, Qingdao, China.
Deng Z; Yinfei Feng Qingdao University of Technology, Qingdao, China.
Wang S; School of Computer Science and Technology, China University of Petroleum, Qingdao, China.
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2023 Jul 06; Vol. 24 (1), pp. 278. Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Development*
Drug Repositioning*
Drug Interactions
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems.
Autorzy:
Fu Z; Department of Liver Surgery and Transplantation, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhang X; The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai, China.
Gao Y; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Fan J; Department of Liver Surgery and Transplantation, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Gao Q; Department of Liver Surgery and Transplantation, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Human Phenome Institute, Fudan University, Shanghai, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2023 Jul; Vol. 13 (7), pp. e1320.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Repositioning*
Neoplasms*
Humans ; Antibodies, Monoclonal/therapeutic use ; Drug Delivery Systems ; Immunity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A polo-like kinase inhibitor identified by computational repositioning attenuates pulmonary fibrosis.
Autorzy:
Imakura T; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Sato S; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Koyama K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Ogawa H; Department of Pathology and Laboratory Medicine, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Niimura T; Department of Clinical Pharmacology and Therapeutics, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Murakami K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Yamashita Y; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Haji K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Naito N; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Kagawa K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Kawano H; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Zamami Y; Department of Clinical Pharmacology and Therapeutics, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.; Department of Pharmacy, Okayama University Hospital, Okayama, Japan.
Ishizawa K; Department of Clinical Pharmacology and Therapeutics, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Nishioka Y; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. .
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Źródło:
Respiratory research [Respir Res] 2023 Jun 02; Vol. 24 (1), pp. 148. Date of Electronic Publication: 2023 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Idiopathic Pulmonary Fibrosis*/metabolism
Mice ; Animals ; Thiophenes/therapeutic use ; Benzimidazoles/metabolism ; Benzimidazoles/pharmacology ; Benzimidazoles/therapeutic use ; Lung/metabolism ; Fibroblasts/metabolism ; Bleomycin/pharmacology
Czasopismo naukowe
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Wyświetlanie 1-20 z 6291

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