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Tytuł :
Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell.
Autorzy :
Ukai S; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Honma R; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Sakamoto N; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yamamoto Y; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Pham QT; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Harada K; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Takashima T; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Taniyama D; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Asai R; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Fukada K; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Naka K; Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Tanabe K; Department of Health Care for Adults, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Ohdan H; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yasui W; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. .
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Źródło :
Oncogene [Oncogene] 2020 Dec; Vol. 39 (50), pp. 7265-7278. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Fluorouracil/*pharmacology
Neoplastic Stem Cells/*drug effects
Neoplastic Stem Cells/*pathology
Organoids/*drug effects
RNA-Binding Proteins/*metabolism
Stomach Neoplasms/*pathology
Aged ; Cell Line, Tumor ; Drug Resistance, Multiple ; Female ; Gene Knockout Techniques ; Humans ; Male ; Middle Aged ; Organoids/pathology ; Prognosis ; RNA-Binding Proteins/genetics ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Detection of multidrug-resistant Gram-negative bacteria from imported reptile and amphibian meats.
Autorzy :
Morrison BJ; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Rubin JE; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
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Źródło :
Journal of applied microbiology [J Appl Microbiol] 2020 Oct; Vol. 129 (4), pp. 1053-1061. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Multiple, Bacterial*/genetics
Internationality*
Anti-Bacterial Agents/*pharmacology
Gram-Negative Bacteria/*isolation & purification
Meat/*microbiology
Amphibians ; Animals ; Canada ; Drug Resistance, Bacterial/genetics ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/genetics ; Reptiles
Czasopismo naukowe
Tytuł :
An understated danger: Antimicrobial resistance in aquaculture and pet fish in Switzerland, a retrospective study from 2000 to 2017.
Autorzy :
Delalay G; Veterinary Public Health Institute, University of Bern, Bern, Switzerland.; Centre for Fish and Wildlife Health, Department of Infectious Diseases and Pathobiology, University of Bern, Bern, Switzerland.; Department of Animal Health, Federal Food Safety and Veterinary Office FSVO, Bern, Switzerland.
Berezowski JA; Veterinary Public Health Institute, University of Bern, Bern, Switzerland.
Diserens N; Koipraxis GmbH, Ulmiz, Switzerland.
Schmidt-Posthaus H; Centre for Fish and Wildlife Health, Department of Infectious Diseases and Pathobiology, University of Bern, Bern, Switzerland.
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Źródło :
Journal of fish diseases [J Fish Dis] 2020 Oct; Vol. 43 (10), pp. 1299-1315. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Bacterial*
Anti-Infective Agents/*pharmacology
Fishes/*microbiology
Animals ; Aquaculture ; Drug Resistance, Multiple, Bacterial ; Fish Diseases/microbiology ; Microbial Sensitivity Tests ; Pets/microbiology ; Retrospective Studies ; Switzerland
Czasopismo naukowe
Tytuł :
Mathematical basis for the assessment of antibiotic resistance and administrative counter-strategies.
Autorzy :
Diebner HH; Carl Gustav Carus Faculty of Medicine, Institute for Medical Informatics and Biometry, Technische Universität Dresden, Dresden, Germany.
Kather A; University Hospital Carl Gustav Carus Dresden at the TU Dresden, Division of Infectious Diseases, Dresden, Germany.
Roeder I; Carl Gustav Carus Faculty of Medicine, Institute for Medical Informatics and Biometry, Technische Universität Dresden, Dresden, Germany.
de With K; University Hospital Carl Gustav Carus Dresden at the TU Dresden, Division of Infectious Diseases, Dresden, Germany.
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Źródło :
PloS one [PLoS One] 2020 Sep 03; Vol. 15 (9), pp. e0238692. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Microbial*
Models, Biological*
Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Drug Resistance, Bacterial ; Time Factors
Czasopismo naukowe
Tytuł :
Joining forces: Leveraging novel combination therapies to combat infections with eukaryotic pathogens.
Autorzy :
Ham RE; Department of Biological Sciences, Clemson University, Clemson, South Carolina, Unites States of America.; Eukaryotic Pathogens Innovation Center (EPIC), Clemson University, Clemson, South Carolina, Unites States of America.
Temesvari LA; Department of Biological Sciences, Clemson University, Clemson, South Carolina, Unites States of America.; Eukaryotic Pathogens Innovation Center (EPIC), Clemson University, Clemson, South Carolina, Unites States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Dec 31; Vol. 16 (12), pp. e1009081. Date of Electronic Publication: 2020 Dec 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Drug Resistance/*physiology
Drug Therapy, Combination/*methods
Anti-Infective Agents/pharmacology ; Antifungal Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Drug Resistance/drug effects ; Drug Resistance, Microbial/drug effects ; Drug Resistance, Microbial/physiology ; Drug Therapy, Combination/trends ; Eukaryota/pathogenicity ; Humans
Czasopismo naukowe
Tytuł :
Ursolic acid reduces Adriamycin resistance of human ovarian cancer cells through promoting the HuR translocation from cytoplasm to nucleus.
Autorzy :
Li W; Department of Gynaecology, The Forth Hospital Affiliated to Jiangsu University, Zhenjiang, China.
Luo L; Department of Obstetrics and Gynecology, Jiangsu Taizhou People's Hospital, Taizhou, China.
Shi W; Department of Gynaecology, the Fourth People's Hospital Affiliated to Jiangsu University, 20 Zhengdong Road, Zhenjiang, 212001, China.
Yin Y; Department of Obstetrics and Gynecology, Dantu District People's Hospital of Zhenjiang, Zhenjiang, China.
Gao S; Department of Obstetrics and Gynecology, Second Provincial People's Hospital of Gansu, the Affiliated Hospital of Northwest Minzu University, Lanzhou, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Feb; Vol. 36 (2), pp. 267-275. Date of Electronic Publication: 2020 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*pharmacology
Cell Nucleus/*metabolism
Cytoplasm/*metabolism
Doxorubicin/*pharmacology
Drug Resistance, Neoplasm/*drug effects
ELAV-Like Protein 1/*metabolism
Ovarian Neoplasms/*pathology
Triterpenes/*pharmacology
Cell Line, Tumor ; Drug Resistance, Multiple/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Ovarian Neoplasms/genetics ; Protein Transport ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Critical discovery and synthesis of novel antibacterial and resistance-modifying agents inspired by plant phytochemical defense mechanisms.
Autorzy :
Soliman SSM; Research Institute for Medical and Health sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates; College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates; Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt. Electronic address: .
Saeed BQ; Research Institute for Medical and Health sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates; Department of Clinical Sciences, College of Medicine, University of Sharjah, P.O. Box 27272, United Arab Emirates.
Elseginy SA; Green Chemistry Department, Chemical Industries Research Division, National Research Center, P.O. Box 12622, Egypt; Molecular Modelling Lab., Biochemistry School, Bristol University, Bristol, UK.
Al-Marzooq F; Research Institute for Medical and Health sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates; Department of medical microbiology and immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Ahmady IM; Department of Applied Biology, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.
El-Keblawy AA; Department of Applied Biology, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates; Research Institutes of Science and Engineering, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.
Hamdy R; Research Institute for Medical and Health sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates; Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Jan 05; Vol. 333, pp. 109318. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Anti-Bacterial Agents/*chemical synthesis
Anti-Bacterial Agents/*pharmacology
Caryophyllales/*chemistry
Drug Resistance, Bacterial/*drug effects
Oils, Volatile/*chemistry
Phytochemicals/*chemistry
Anti-Bacterial Agents/chemistry ; Biomimetic Materials/chemical synthesis ; Biomimetic Materials/chemistry ; Biomimetic Materials/pharmacology ; Cell Line ; Chemistry Techniques, Synthetic ; Drug Resistance, Multiple/drug effects ; Humans
Czasopismo naukowe
Tytuł :
Exploiting evolutionary trade-offs for posttreatment management of drug-resistant populations.
Autorzy :
Melnikov SV; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520; .
Stevens DL; Department of Chemistry, Yale University, New Haven, CT 06520.
Fu X; Guangdong Provincial Key Laboratory of Genome Read and Write, 518120 Shenzhen, China.; BGI-Shenzhen, 518083 Shenzhen, China.; China National Genebank, BGI-Shenzhen, 518120 Shenzhen, China.
Kwok HS; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520.
Zhang JT; BGI-Shenzhen, 518083 Shenzhen, China.; China National Genebank, BGI-Shenzhen, 518120 Shenzhen, China.
Shen Y; Guangdong Provincial Key Laboratory of Genome Read and Write, 518120 Shenzhen, China.; BGI-Shenzhen, 518083 Shenzhen, China.; China National Genebank, BGI-Shenzhen, 518120 Shenzhen, China.
Sabina J; Thermo Fisher Scientific, Guilford, CT 06437.
Lee K; Erbi Biosystems, Woburn, MA 01801.
Lee H; Erbi Biosystems, Woburn, MA 01801.
Söll D; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520; .; Department of Chemistry, Yale University, New Haven, CT 06520.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 28; Vol. 117 (30), pp. 17924-17931. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Evolution*
Drug Resistance*
Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Genetic Variation ; Models, Molecular ; Protein Conformation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Chemotherapy-Induced IL8 Upregulates MDR1/ABCB1 in Tumor Blood Vessels and Results in Unfavorable Outcome.
Autorzy :
Kikuchi H; Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Maishi N; Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; Department of Vascular Biology and Molecular Pathology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Hokkaido, Japan.
Annan DA; Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; Department of Vascular Biology and Molecular Pathology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Hokkaido, Japan.
Alam MT; Department of Vascular Biology and Molecular Pathology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Hokkaido, Japan.; Department of Dental Radiology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Hokkaido, Japan.
Dawood RIH; Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Sato M; Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Morimoto M; Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; Department of Vascular Biology and Molecular Pathology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Hokkaido, Japan.
Takeda R; Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Ishizuka K; Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Matsumoto R; Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.; Department of Urology, Teine Keijinkai Hospital, Sapporo, Hokkaido, Japan.
Akino T; Department of Urology, Sapporo City General Hospital, Sapporo, Hokkaido, Japan.; Department of Urology, Tonan Hospital, Sapporo, Hokkaido, Japan.
Tsuchiya K; Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.; Department of Urology, KKR Sapporo Medical Center, Sapporo, Hokkaido, Japan.
Abe T; Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Osawa T; Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Miyajima N; Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.; Department of Urology, Teine Keijinkai Hospital, Sapporo, Hokkaido, Japan.
Maruyama S; Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.; Department of Urology, Hokkaido Cancer Center, Sapporo, Hokkaido, Japan.
Harabayashi T; Department of Urology, Hokkaido Cancer Center, Sapporo, Hokkaido, Japan.
Azuma M; Department of Pathology, Hokkaido Cancer Center, Sapporo, Hokkaido, Japan.
Yamashiro K; Department of Pathology, Hokkaido Cancer Center, Sapporo, Hokkaido, Japan.
Ameda K; Hokkaido Hinyokika Kinen Hospital, Sapporo, Hokkaido, Japan.
Kashiwagi A; Department of Urology, Teine Keijinkai Hospital, Sapporo, Hokkaido, Japan.
Matsuno Y; Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Hida Y; Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Shinohara N; Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Hida K; Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan. .; Department of Vascular Biology and Molecular Pathology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Hokkaido, Japan.
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Źródło :
Cancer research [Cancer Res] 2020 Jul 15; Vol. 80 (14), pp. 2996-3008. Date of Electronic Publication: 2020 Jun 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Biomarkers, Tumor/*metabolism
Interleukin-8/*metabolism
Neovascularization, Pathologic/*pathology
Paclitaxel/*pharmacology
Urinary Bladder Neoplasms/*mortality
ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Adult ; Aged ; Aged, 80 and over ; Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Drug Resistance, Multiple ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Induction Chemotherapy ; Interleukin-8/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neovascularization, Pathologic/chemically induced ; Prognosis ; Survival Rate ; Tumor Cells, Cultured ; Urinary Bladder Neoplasms/blood supply ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Antimicrobial resistance of Pasteurella multocida type B isolates associated with acute septicemia in pigs and cattle in Spain.
Autorzy :
Cuevas I; Department of Animal Health (AGR-149). Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University Campus, 14071, Córdoba, Spain.
Carbonero A; Department of Animal Health (AGR-149). Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University Campus, 14071, Córdoba, Spain.
Cano D; Department of Animal Health (AGR-149). Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University Campus, 14071, Córdoba, Spain.
García-Bocanegra I; Department of Animal Health (AGR-149). Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University Campus, 14071, Córdoba, Spain.
Amaro MÁ; Department of Bromatology. Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University Campus, 14071, Córdoba, Spain.
Borge C; Department of Animal Health (AGR-149). Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University Campus, 14071, Córdoba, Spain. .
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Źródło :
BMC veterinary research [BMC Vet Res] 2020 Jun 30; Vol. 16 (1), pp. 222. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Bacterial*
Anti-Bacterial Agents/*pharmacology
Cattle Diseases/*microbiology
Pasteurella multocida/*drug effects
Swine Diseases/*microbiology
Animals ; Cattle ; Drug Resistance, Multiple ; Microbial Sensitivity Tests/veterinary ; Pasteurella Infections/microbiology ; Pasteurella Infections/veterinary ; Pasteurella multocida/isolation & purification ; Sepsis/microbiology ; Sepsis/veterinary ; Spain ; Swine
Czasopismo naukowe
Tytuł :
[Effect of Bmi-1 on Multidrug Resistance in K562/ADR Cells and Its Mechanisms].
Autorzy :
Zhao BX; Department of Clinical Hematology, Laboratorial Medicine College of Dalian Medical University, Dalian 116044, Liaoning Province, China.
Liu SQ; Department of Laboratorial Medicine, Municipal Hospital Affiliated to Xuzhou Medical College,Xuzhou 221005, Jiangsu Province, China.
Dong SC; Department of Clinical Hematology, Laboratorial Medicine College of Dalian Medical University, Dalian 116044, Liaoning Province, China.
Jing RN; Department of Clinical Hematology, Laboratorial Medicine College of Dalian Medical University, Dalian 116044, Liaoning Province, China.
Meng XX; Department of Clinical Hematology, Laboratorial Medicine College of Dalian Medical University, Dalian 116044, Liaoning Province, China,E-mail: .
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2020 Jun; Vol. 28 (3), pp. 758-766.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Doxorubicin ; Drug Resistance, Multiple ; Humans ; K562 Cells ; Mitogen-Activated Protein Kinase 7
Czasopismo naukowe
Tytuł :
[Research Advance on Reversing Multidrug Resistance of Chronic Myeloid Leukemia by Chinese Herbal Monomer--Review].
Autorzy :
Sun Y; Department of Pediatrics, Children's Blood and Tumor Research Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, Chinna.
Liu WJ; Department of Pediatrics, Children's Blood and Tumor Research Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, Chinna,E-mail:.
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2020 Jun; Vol. 28 (3), pp. 1064-1068.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Resistance, Multiple*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Antineoplastic Agents ; Drug Resistance, Neoplasm ; Drugs, Chinese Herbal ; Humans ; Medicine, Chinese Traditional
Czasopismo naukowe
Tytuł :
Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5- a ]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators.
Autorzy :
Wang S; School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou 450001, China.
Wang SQ; Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Henan Cancer Institute, Zhengzhou 450008, China.
Teng QX; College of Pharmacy and Health Sciences, St. John's University, Queens, New York 11439, United States.
Yang L; Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Lei ZN; College of Pharmacy and Health Sciences, St. John's University, Queens, New York 11439, United States.
Yuan XH; School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou 450001, China.
Huo JF; School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou 450001, China.
Chen XB; Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Henan Cancer Institute, Zhengzhou 450008, China.
Wang M; Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Yu B; School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou 450001, China.
Chen ZS; College of Pharmacy and Health Sciences, St. John's University, Queens, New York 11439, United States.
Liu HM; School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou 450001, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Dec 24; Vol. 63 (24), pp. 15979-15996. Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Synergism*
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Colonic Neoplasms/*drug therapy
Drug Resistance, Neoplasm/*drug effects
Pyrimidines/*chemistry
ATP Binding Cassette Transporter, Subfamily B/agonists ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis ; Cell Proliferation ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Drug Resistance, Multiple/drug effects ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Paclitaxel/pharmacology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Novel nano-pomegranates based on astragalus polysaccharides for targeting ERα-positive breast cancer and multidrug resistance.
Autorzy :
Wang B; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P.R. China.
Guo C; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P.R. China.
Liu Y; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, P. R. China.
Han G; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, P. R. China.
Li Y; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P.R. China.; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, P. R. China.
Zhang Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Xu H; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P. R. China.
Chen D; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P.R. China.; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, P. R. China.
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Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 607-621.
Typ publikacji :
Journal Article
MeSH Terms :
Astragalus Plant/*chemistry
Breast Neoplasms/*drug therapy
Drug Resistance, Neoplasm/*drug effects
Estrogen Receptor alpha/*metabolism
Nanoparticles/*chemistry
Polysaccharides/*administration & dosage
Animals ; Curcumin/administration & dosage ; Curcumin/pharmacokinetics ; Curcumin/pharmacology ; Drug Carriers/administration & dosage ; Drug Carriers/pharmacokinetics ; Drug Carriers/pharmacology ; Drug Delivery Systems/methods ; Drug Liberation ; Drug Resistance, Multiple/drug effects ; Female ; Folic Acid/administration & dosage ; Folic Acid/pharmacokinetics ; Folic Acid/pharmacology ; Humans ; MCF-7 Cells ; Mice, Nude ; Polysaccharides/chemistry ; Polysaccharides/pharmacokinetics ; Polysaccharides/pharmacology ; Quercetin/administration & dosage ; Quercetin/pharmacokinetics ; Quercetin/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
A multiple-targets alkaloid nuciferine overcomes paclitaxel-induced drug resistance in vitro and in vivo.
Autorzy :
Liu RM; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau (SAR).
Xu P; Department of Nephrology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, P. R. China.
Chen Q; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau (SAR).
Feng SL; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau (SAR).
Xie Y; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau (SAR). Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2020 Dec; Vol. 79, pp. 153342. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Aporphines/*pharmacology
Drug Resistance, Neoplasm/*drug effects
ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Animals ; Cell Line, Tumor ; Docetaxel/pharmacology ; Doxorubicin/pharmacology ; Drug Resistance, Multiple/drug effects ; Female ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mice, Inbred BALB C ; Molecular Targeted Therapy ; Neoplasm Proteins/metabolism ; Paclitaxel/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Functionalized Carbon Nanostructures Versus Drug Resistance: Promising Scenarios in Cancer Treatment.
Autorzy :
Curcio M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy.
Farfalla A; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy.
Saletta F; Lowy Cancer Research Centre, Children's Cancer Institute, UNSW Sydney, NSW 2031, Australia.; School of Women's and Children's Health, Faculty of Medicine, UNSW Sydney, NSW 2052, Australia.; ARC Centre of Excellence for Convergent BioNano Science and Technology, Australian Centre for NanoMedicine, UNSW Sydney, NSW 2052, Australia.
Valli E; Lowy Cancer Research Centre, Children's Cancer Institute, UNSW Sydney, NSW 2031, Australia.; School of Women's and Children's Health, Faculty of Medicine, UNSW Sydney, NSW 2052, Australia.
Pantuso E; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy.
Nicoletta FP; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy.
Iemma F; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy.
Vittorio O; Lowy Cancer Research Centre, Children's Cancer Institute, UNSW Sydney, NSW 2031, Australia.; School of Women's and Children's Health, Faculty of Medicine, UNSW Sydney, NSW 2052, Australia.; ARC Centre of Excellence for Convergent BioNano Science and Technology, Australian Centre for NanoMedicine, UNSW Sydney, NSW 2052, Australia.
Cirillo G; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Apr 30; Vol. 25 (9). Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Resistance, Neoplasm*
Antineoplastic Agents/*chemistry
Carbon/*chemistry
Nanostructures/*chemistry
ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Drug Carriers/chemistry ; Drug Delivery Systems ; Drug Resistance, Multiple ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
IRE1α-targeting downregulates ABC transporters and overcomes drug resistance of colon cancer cells.
Autorzy :
Gao Q; Shanghai Institute of Nutrition and Health, Shanghai Institutes of Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Li XX; Shanghai Institute of Nutrition and Health, Shanghai Institutes of Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Xu YM; Shanghai Institute of Nutrition and Health, Shanghai Institutes of Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhang JZ; Shanghai Institute of Nutrition and Health, Shanghai Institutes of Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Rong SD; Shanghai Institute of Nutrition and Health, Shanghai Institutes of Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Qin YQ; Shanghai Institute of Nutrition and Health, Shanghai Institutes of Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Fang J; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao, 266061, China; Cancer Institute, Qingdao University, Qingdao, 266061, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Apr 28; Vol. 476, pp. 67-74. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors
Colonic Neoplasms/*drug therapy
Endoribonucleases/*antagonists & inhibitors
Fluorouracil/*pharmacology
Multidrug Resistance-Associated Proteins/*antagonists & inhibitors
Neoplasm Proteins/*antagonists & inhibitors
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Animals ; Antimetabolites, Antineoplastic/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Proliferation ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Drug Resistance, Multiple ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Drug resistance of previously treated tuberculosis patients with diabetes mellitus in Shandong, China.
Autorzy :
Song WM; Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, PR China; Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, PR China.
Li YF; Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, PR China.
Liu JY; Department of Intensive Care Unit, Shandong Provincial Third Hospital, 100191, Jinan, Shandong, PR China.
Tao NN; Department of Respiratory and Critical Care Medicine, Beijing Hospital, 100730, Beijing, PR China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, Beijing, PR China.
Liu Y; Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, PR China.
Zhang QY; Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, PR China; Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, PR China.
Xu TT; Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, PR China.
Li SJ; Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, PR China; Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, PR China.
An QQ; Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, PR China; Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, PR China.
Liu SQ; Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, PR China; Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, PR China.
Yu CB; Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Chest Hospital, 250013, Jinan, Shandong, PR China.
Gao L; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, Beijing, PR China.
Yu CX; Department of Respiratory Medicine, Shandong Qianfoshan Hospital Affiliated to Shandong University, 250014, Jinan, Shandong Province, PR China.
Zhang M; Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, PR China. Electronic address: .
Li HC; Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, PR China; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, 250355, Jinan, Shandong, PR China. Electronic address: .
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Źródło :
Respiratory medicine [Respir Med] 2020 Mar; Vol. 163, pp. 105897. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Bacterial*
Antitubercular Agents/*pharmacology
Diabetes Mellitus/*epidemiology
Mycobacterium tuberculosis/*drug effects
Tuberculosis/*epidemiology
Tuberculosis/*microbiology
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; China ; Comorbidity ; Drug Resistance, Multiple ; Female ; Humans ; Infant ; Male ; Middle Aged ; Risk Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Phospholipids and cholesterol: Inducers of cancer multidrug resistance and therapeutic targets.
Autorzy :
Kopecka J; Department of Oncology, University of Torino, Italy.
Trouillas P; UMR 1248 INSERM, Univeristy of Limoges, Limoges, France; RCPTM, University Palacký of Olomouc, Olomouc, Czech Republic.
Gašparović AČ; Division of Molecular Medicine, Institute Ruđer Bošković, Zagreb, Croatia.
Gazzano E; Department of Oncology, University of Torino, Italy.
Assaraf YG; The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
Riganti C; Department of Oncology, University of Torino, Italy; Interdepartmental Center of Research in Molecular Biotechnology, University of Torino, Italy. Electronic address: .
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Źródło :
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy [Drug Resist Updat] 2020 Mar; Vol. 49, pp. 100670. Date of Electronic Publication: 2019 Nov 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Resistance, Neoplasm*
Antineoplastic Agents/*pharmacology
Neoplasms/*drug therapy
Cell Membrane/metabolism ; Cholesterol/metabolism ; Drug Resistance, Multiple ; High-Throughput Screening Assays ; Humans ; Neoplasms/metabolism ; Phospholipids/metabolism
Czasopismo naukowe
Tytuł :
The role of "spillover" in antibiotic resistance.
Autorzy :
Olesen SW; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.
Lipsitch M; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.; Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, MA 02115.
Grad YH; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115; .; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 17; Vol. 117 (46), pp. 29063-29068. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Anti-Bacterial Agents/*administration & dosage
Drug Resistance, Microbial/*drug effects
Drug Resistance, Microbial/*physiology
Antimicrobial Stewardship ; Bacteria/drug effects ; Cross-Sectional Studies ; Drug Resistance, Bacterial/drug effects ; Europe ; Hospitals ; Humans ; Streptococcus pneumoniae/drug effects ; United States
Czasopismo naukowe

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