Temat: "Drug Resistance" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Degradation trumps mutations in cancer.
Autorzy:: Davis RE; Department of Lymphoma and Myeloma, MD Anderson Cancer Center, Houston, TX, USA.
Westin JR; Department of Lymphoma and Myeloma, MD Anderson Cancer Center, Houston, TX, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2024 Feb 02; Vol. 383 (6682), pp. 480-481. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Resistance, Neoplasm*/drug effects
Drug Resistance, Neoplasm*/genetics
Protein Kinase Inhibitors*/pharmacology
Protein Kinase Inhibitors*/therapeutic use
Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell*/genetics
Proteolysis*/drug effects
Cell Line, Tumor ; Mutation ; Humans

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Skocz do pozycji: 2.

Tytuł:: Discovery of Novel 4-Hydroxyquinazoline Derivatives: In Silico, In Vivo and In Vitro Studies Using Primary PARPi-Resistant Cell Lines.
Autorzy:: Zhu L; School of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Liu B; School of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Jin F; School of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Cao W; School of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Xu G; School of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Zhang X; School of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Peng P; School of Pharmacy (Preparatory), East China Normal University, Shanghai 200241, China.
Gao D; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Wang B; School of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Feng K; School of Pharmacy, Shandong Second Medical University, Weifang 261053, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Mar 21; Vol. 29 (6). Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Resistance, Neoplasm*
Antineoplastic Agents*/pharmacology
Quinazolinones*
Molecular Docking Simulation ; Cell Line, Tumor

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Skocz do pozycji: 3.

Tytuł:: Role of CD44 in Chemotherapy Treatment Outcome: A Scoping Review of Clinical Studies.
Autorzy:: Wu Z; Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Lu J; Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Loo A; Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Ho N; Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Nguyen D; Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Cheng PY; Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Mohammed AI; Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Cirillo N; Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.; School of Dentistry, University of Jordan, Amman 11942, Jordan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 08; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:: Systematic Review; Journal Article; Review
MeSH Terms:: Drug Resistance, Neoplasm*
Hyaluronan Receptors*/genetics
Hyaluronan Receptors*/metabolism
Humans ; Treatment Outcome

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Skocz do pozycji: 4.

Tytuł:: Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells.
Autorzy:: Gagliardi S; Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy.
Mitruccio M; Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy.
Di Corato R; Institute for Microelectronics and Microsystems (IMM), CNR, Via Monteroni, Lecce, 73100, Italy.; Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Arnesano, 73010, Italy.
Romano R; Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy.; Department of Experimental Medicine, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy.
Aloisi A; Institute for Microelectronics and Microsystems (IMM), CNR, Via Monteroni, Lecce, 73100, Italy.
Rinaldi R; Department of Mathematics and Physics 'E. De Giorgi', University of Salento, Via Monteroni, Lecce, 73100, Italy.; Scuola Superiore ISUFI, University of Salento, Via Monteroni, University Campus, Lecce, 73100, Italy.
Alifano P; Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy.; Department of Experimental Medicine, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy.
Guerra F; Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy.
Bucci C; Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy. .; Department of Experimental Medicine, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Mar 06; Vol. 22 (1), pp. 165. Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Resistance, Neoplasm*
Ovarian Neoplasms*/drug therapy
Female ; Humans ; Lysosomes ; Mitochondria ; Cisplatin/pharmacology

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Skocz do pozycji: 5.

Tytuł:: Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
Autorzy:: Cheng B; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.; Department of Urology, Fujian Medical University Union Hospital, Fuzhou, China.
Li L; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Luo T; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Wang Q; Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, 511430, China.
Luo Y; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Bai S; Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Li K; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .
Lai Y; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .
Huang H; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .; Guangdong Provincial Clinical Research Center for Urological Diseases, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .; Department of Urology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, 511518, Guangdong, China. .; Pokaż więcej
Źródło:: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Mar 01; Vol. 43 (1), pp. 67. Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:: Journal Article
MeSH Terms:: Interleukin-11*/genetics
Interleukin-11*/metabolism
Prostatic Neoplasms*/drug therapy
Prostatic Neoplasms*/genetics
Prostatic Neoplasms*/metabolism
Drug Resistance, Neoplasm*/genetics
Humans ; Male ; Docetaxel/pharmacology ; Gene Expression Regulation ; Janus Kinase 1/genetics ; Janus Kinase 1/metabolism ; Signal Transduction ; STAT4 Transcription Factor/metabolism

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Skocz do pozycji: 6.

Tytuł:: Inhibition of LATS kinases reduces tumorigenicity and increases the sensitivity of human chronic myelogenous leukemia cells to imatinib.
Autorzy:: Klaihmon P; Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Lorthongpanich C; Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. .; Blood Products and Cellular Immunotherapy Research Group, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand. .
Kheolamai P; Center of Excellence in Stem Cell Research and Innovations, Division of Cell Biology, Faculty of Medicine, Thammasat University, Pathumthani, Thailand. .
Saisaard W; Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Issaragrisil S; Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 18; Vol. 14 (1), pp. 3993. Date of Electronic Publication: 2024 Feb 18.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Resistance, Neoplasm*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/pathology
Humans ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Fusion Proteins, bcr-abl/genetics ; Protein Serine-Threonine Kinases ; K562 Cells ; Apoptosis ; Tumor Suppressor Proteins

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Skocz do pozycji: 7.

Tytuł:: HIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process.
Autorzy:: Ma S; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Wang J; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Cui Z; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Yang X; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Cui X; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Li X; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Zhao L; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China. .; Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China. .; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China. .; Precision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 16; Vol. 14 (1), pp. 3870. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*/genetics
Drug Resistance, Neoplasm*/genetics
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/pathology
Female ; Humans ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Cisplatin/pharmacology ; DNA Repair ; Hypoxia ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Tumor Microenvironment

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Skocz do pozycji: 8.

Tytuł:: Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Autorzy:: Montoya S; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Bourcier J; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Noviski M; Nurix Therapeutics, San Francisco, CA, USA.
Lu H; Nurix Therapeutics, San Francisco, CA, USA.
Thompson MC; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chirino A; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Jahn J; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Sondhi AK; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Gajewski S; Nurix Therapeutics, San Francisco, CA, USA.
Tan YSM; Nurix Therapeutics, San Francisco, CA, USA.
Yung S; Nurix Therapeutics, San Francisco, CA, USA.
Urban A; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; K.G. Jebsen Centre for B Cell Malignancies, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Wang E; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Han C; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Mi X; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kim WJ; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sievers Q; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Auger P; Nurix Therapeutics, San Francisco, CA, USA.
Bousquet H; Nurix Therapeutics, San Francisco, CA, USA.
Brathaban N; Nurix Therapeutics, San Francisco, CA, USA.
Bravo B; Nurix Therapeutics, San Francisco, CA, USA.
Gessner M; Nurix Therapeutics, San Francisco, CA, USA.
Guiducci C; Nurix Therapeutics, San Francisco, CA, USA.
Iuliano JN; Nurix Therapeutics, San Francisco, CA, USA.
Kane T; Nurix Therapeutics, San Francisco, CA, USA.
Mukerji R; Nurix Therapeutics, San Francisco, CA, USA.
Reddy PJ; Nurix Therapeutics, San Francisco, CA, USA.
Powers J; Nurix Therapeutics, San Francisco, CA, USA.
Sanchez Garcia de Los Rios M; Nurix Therapeutics, San Francisco, CA, USA.
Ye J; Nurix Therapeutics, San Francisco, CA, USA.
Barrientos Risso C; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Tsai D; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Pardo G; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Notti RQ; Laboratory of Molecular Electron Microscopy, Rockefeller University, New York, NY, USA.
Pardo A; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Affer M; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Nawaratne V; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Totiger TM; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Pena-Velasquez C; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Rhodes JM; Division of Hematology-Oncology, Department of Medicine at Zucker School of Medicine at Hofstra/Northwell, CLL Research and Treatment Center, Lake Success, NY, USA.
Zelenetz AD; Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alencar A; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Roeker LE; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mehta S; Gene Editing and Screening Core Facility, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Institute and Cancer Center, New York, NY, USA.
Garippa R; Gene Editing and Screening Core Facility, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Institute and Cancer Center, New York, NY, USA.
Linley A; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Soni RK; Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Skånland SS; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; K.G. Jebsen Centre for B Cell Malignancies, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Brown RJ; Nurix Therapeutics, San Francisco, CA, USA.
Mato AR; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Hansen GM; Nurix Therapeutics, San Francisco, CA, USA.
Abdel-Wahab O; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Taylor J; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2024 Feb 02; Vol. 383 (6682), pp. eadi5798. Date of Electronic Publication: 2024 Feb 02.
Typ publikacji:: Journal Article
MeSH Terms:: Agammaglobulinaemia Tyrosine Kinase*/genetics
Agammaglobulinaemia Tyrosine Kinase*/metabolism
Ikaros Transcription Factor*/metabolism
Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell*/genetics
Protein Kinase Inhibitors*/pharmacology
Protein Kinase Inhibitors*/therapeutic use
Proteolysis*/drug effects
Drug Resistance, Neoplasm*/drug effects
Humans ; Mutation ; Phosphorylation ; Signal Transduction

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Skocz do pozycji: 9.

Tytuł:: IFITM3-mediated activation of TRAF6/MAPK/AP-1 pathways induces acquired TKI resistance in clear cell renal cell carcinoma.
Autorzy:: Jeong SU; Department of Pathology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.
Park JM; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Yoon SY; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Hwang HS; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Go H; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Shin DM; Department of Cell and Genetic Engineering, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ju H; Department of Cell and Genetic Engineering, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Sung CO; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Lee JL; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jeong G; AI Recommendation, T3K, SK Telecom, Seoul, Korea.
Cho YM; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. .; Pokaż więcej
Źródło:: Investigative and clinical urology [Investig Clin Urol] 2024 Jan; Vol. 65 (1), pp. 84-93.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Renal Cell*/drug therapy
Membrane Proteins*/genetics
RNA-Binding Proteins*/genetics
Tyrosine Kinase Inhibitors*/pharmacology
Drug Resistance, Neoplasm*
Humans ; Sunitinib/pharmacology ; TNF Receptor-Associated Factor 6 ; Transcription Factor AP-1 ; Vascular Endothelial Growth Factor A

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Skocz do pozycji: 10.

Tytuł:: The Relationship between Trop-2, Chemotherapeutic Drugs, and Chemoresistance.
Autorzy:: Koltai T; Hospital del Centro Gallego de Buenos Aires, Buenos Aires 2199, Argentina.
Fliegel L; Department of Biochemistry, Faculty of Medicine, University of Alberta, 347 Medical Science Bldg., Edmonton, AB T6G 2H7, Canada.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 20; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 20.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Drug Resistance, Neoplasm*
Amyloidosis, Familial*
Female ; Pregnancy ; Animals ; Biological Transport ; Calcium, Dietary ; Cell Proliferation ; Mammals

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Skocz do pozycji: 11.

Tytuł:: Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to Immunotherapy.
Autorzy:: He J; Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China. .; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, 410008, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, 410008, Huan, China. .; Hunan International Science and Technology Collaboration Base of Precision Medicine for Cancer, Changsha, 410008, China. .; Center for Molecular Imaging of Central, South University, Xiangya Hospital, Changsha, 410008, China. .
Zhou Y; Department of Pathology, Tongji Medical College Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.
Sun L; Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China. .; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, 410008, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, 410008, Huan, China. .; Hunan International Science and Technology Collaboration Base of Precision Medicine for Cancer, Changsha, 410008, China. .; Center for Molecular Imaging of Central, South University, Xiangya Hospital, Changsha, 410008, China. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Jan 31; Vol. 22 (1), pp. 89. Date of Electronic Publication: 2024 Jan 31.
Typ publikacji:: Video-Audio Media; Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Resistance, Neoplasm*
Neoplasms*/drug therapy
Neoplasms*/pathology
Humans ; Unfolded Protein Response ; Endoplasmic Reticulum Stress ; Immunotherapy ; Tumor Microenvironment

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Skocz do pozycji: 12.

Tytuł:: ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia.
Autorzy:: Lai J; Department of Medicine, Division of Hematology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Yang C; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Shang C; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Chen W; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Chu MP; Department of Medicine, Division of Hematology, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Department of Medical Oncology, Cross Cancer Institute, Edmonton, AB T6G 1Z2, Canada.
Brandwein J; Department of Medicine, Division of Hematology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Lai R; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Department of Medical Oncology, Cross Cancer Institute, Edmonton, AB T6G 1Z2, Canada.
Wang P; Department of Medicine, Division of Hematology, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Department of Medical Oncology, Cross Cancer Institute, Edmonton, AB T6G 1Z2, Canada.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 04; Vol. 25 (1). Date of Electronic Publication: 2024 Jan 04.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Resistance, Neoplasm*/genetics
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Protein Serine-Threonine Kinases*/genetics
Humans ; Autophagy/genetics ; Biological Assay ; Chronic Disease ; Cytarabine/pharmacology ; fms-Like Tyrosine Kinase 3/genetics

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Skocz do pozycji: 13.

Tytuł:: High-expressed ACAT2 predicted the poor prognosis of platinum-resistant epithelial ovarian cancer.
Autorzy:: Wang J; Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China.
Yang Z; Department of Pathology, First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China.
Bai H; The MED-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi'an, 710000, China.
Zhao L; Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China.
Ji J; Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China.
Bin Y; Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China.
Liu Y; Department of Pathology, First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China.
Zhang S; Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China.
Hou H; Department of Pathology, First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China. .
Li Q; Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China. .; Pokaż więcej
Źródło:: Diagnostic pathology [Diagn Pathol] 2024 Jan 04; Vol. 19 (1), pp. 7. Date of Electronic Publication: 2024 Jan 04.
Typ publikacji:: Journal Article
MeSH Terms:: Ovarian Neoplasms*/pathology
Drug Resistance, Neoplasm*
Female ; Humans ; Acetyltransferases ; Carcinoma, Ovarian Epithelial/pathology ; Cell Line, Tumor ; Prognosis

Czasopismo naukowe

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Skocz do pozycji: 14.

Tytuł:: Prediction of Chemoresistance-How Preclinical Data Could Help to Modify Therapeutic Strategy in High-Grade Serous Ovarian Cancer.
Autorzy:: Wilczyński J; Department of Gynecological Surgery and Gynecological Oncology, Medical University of Lodz, 4 Kosciuszki Str., 90-419 Lodz, Poland.
Paradowska E; Laboratory of Virology, Institute of Medical Biology of the Polish Academy of Sciences, 106 Lodowa Str., 93-232 Lodz, Poland.
Wilczyńska J; Department of Tele-Radiotherapy, Mikolaj Kopernik Provincial Multi-Specialized Oncology and Traumatology Center, 62 Pabianicka Str., 93-513 Lodz, Poland.
Wilczyński M; Department of Gynecological, Endoscopic and Oncological Surgery, Polish Mother's Health Center-Research Institute, 281/289 Rzgowska Str., 93-338 Lodz, Poland.; Department of Surgical and Endoscopic Gynecology, Medical University of Lodz, 4 Kosciuszki Str., 90-419 Lodz, Poland.; Pokaż więcej
Źródło:: Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Dec 29; Vol. 31 (1), pp. 229-249. Date of Electronic Publication: 2023 Dec 29.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Drug Resistance, Neoplasm*
Ovarian Neoplasms*/drug therapy
Humans ; Female ; Epigenesis, Genetic ; Neoplasm Recurrence, Local ; Biomarkers ; Tumor Microenvironment

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Skocz do pozycji: 15.

Tytuł:: IL20RB signaling enhances stemness and chemotherapy resistance in pancreatic cancer.
Autorzy:: Li XH; Department of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfengdong Road, Guangzhou, 510060, China.
Huang GZ; Department of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfengdong Road, Guangzhou, 510060, China.
Xu ZL; Department of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfengdong Road, Guangzhou, 510060, China.
Zhao CY; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Army Medical University, Chongqing, 400037, China.
Dong XY; Department of Gynecology, Guangdong Hydropower Hospital, Guangzhou, 510060, China.
Cui BK; Department of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfengdong Road, Guangzhou, 510060, China.
Lin XJ; Department of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfengdong Road, Guangzhou, 510060, China. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2023 Dec 14; Vol. 21 (1), pp. 911. Date of Electronic Publication: 2023 Dec 14.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Resistance, Neoplasm*
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/genetics
Pancreatic Neoplasms*/metabolism
Humans ; Cell Line, Tumor ; Signal Transduction ; Prognosis ; Neoplastic Stem Cells/pathology ; Tumor Microenvironment

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Skocz do pozycji: 16.

Tytuł:: Sorafenib regulates c-CBL gene-mediated chemoresistance in acute myeloid leukemia cells.
Autorzy:: Sun Q; Department of Geriatric Hematology and Oncology, Guangzhou First People's Hospital, Guangzhou, China.
Wu B; Department of Hematology and Oncology, Cancer Center of Sun Yat-sen University, Guangzhou, China.; Department of Hematology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Meng F; Department of Hematology, Kanghua Hospital, Dongguan, China.
Yao Q; Department of Hematology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Huang Z; Department of Hematology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Xu J; Department of Hematology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Zhu Z; Department of Geriatric Hematology and Oncology, Guangzhou First People's Hospital, Guangzhou, China.; Pokaż więcej
Źródło:: Hematology (Amsterdam, Netherlands) [Hematology] 2023 Dec; Vol. 28 (1), pp. 2204620.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Resistance, Neoplasm*/genetics
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Sorafenib*/pharmacology
Sorafenib*/therapeutic use
Humans ; Apoptosis ; fms-Like Tyrosine Kinase 3/genetics ; Mutation ; Proto-Oncogene Proteins c-cbl/genetics ; Receptor Protein-Tyrosine Kinases/genetics

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Skocz do pozycji: 17.

Tytuł:: Advance in Targeted Cancer Therapy and Mechanisms of Resistance.
Autorzy:: Tang PM; State Key Laboratory of Translational Oncology, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Zhang D; College of Pharmacy, Jinan University, Guangzhou 510632, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 22; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 22.
Typ publikacji:: Editorial
MeSH Terms:: Drug Resistance, Neoplasm*
Neoplasms*/drug therapy
Humans

Opinia redakcyjna

na półce

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Skocz do pozycji: 18.

Tytuł:: SuperNatural inhibitors to reverse multidrug resistance emerged by ABCB1 transporter: Database mining, lipid-mediated molecular dynamics, and pharmacokinetics study.
Autorzy:: Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.; School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Abdeljawaad KAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Abdelrahman AHM; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Abdelhamid MMH; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Naeem MA; Nutrition and Food Sciences, Ain Shams University Specialized Hospital, Ain Shams University, Cairo, Egypt.
Mekhemer GAH; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Sidhom PA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Sayed SRM; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Paré PW; Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, Texas, United States of America.
Hegazy MF; Chemistry of Medicinal Plants Department, National Research Centre, Giza, Egypt.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Jul 26; Vol. 18 (7), pp. e0288919. Date of Electronic Publication: 2023 Jul 26 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Molecular Dynamics Simulation*
Drug Resistance, Neoplasm*
ATP Binding Cassette Transporter, Subfamily B/metabolism ; Drug Resistance, Multiple ; Lipids/pharmacology ; Molecular Docking Simulation ; Cell Line, Tumor

Czasopismo naukowe

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Skocz do pozycji: 19.

Tytuł:: The Illustration of Altered Glucose Dependency in Drug-Resistant Cancer Cells.
Autorzy:: Bishayee K; Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Lee SH; Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Park YS; Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 11; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 11.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Drug Resistance, Neoplasm*
Neoplasms*
Humans ; Glucose/metabolism

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na półce

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Skocz do pozycji: 20.

Tytuł:: c-FOS is an integral component of the IKZF1 transactivator complex and mediates lenalidomide resistance in multiple myeloma.
Autorzy:: Osada N; Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.
Kikuchi J; Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.
Iha H; Division of Pathophysiology, The Research Center for GLOBAL and LOCAL Infectious Diseases (RCGLID), Oita University, Oita, Japan.
Yasui H; Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.; Project Division of Innovative Diagnostics Technology Platform, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Ikeda S; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
Takahashi N; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
Furukawa Y; Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.; Center for Medical Education, Teikyo University of Science, Tokyo, Japan.; Pokaż więcej
Źródło:: Clinical and translational medicine [Clin Transl Med] 2023 Aug; Vol. 13 (8), pp. e1364.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Ikaros Transcription Factor*/genetics
Ikaros Transcription Factor*/metabolism
Lenalidomide*/pharmacology
Lenalidomide*/therapeutic use
Multiple Myeloma*/drug therapy
Multiple Myeloma*/genetics
Drug Resistance, Neoplasm*
Proto-Oncogene Proteins c-fos*/genetics
Proto-Oncogene Proteins c-fos*/metabolism
Animals ; Humans ; Mice ; Bone Marrow ; Trans-Activators/therapeutic use ; Transcription Factor AP-1/therapeutic use

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na półce

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