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Wyszukujesz frazę ""Drug Resistance, Neoplasm"" wg kryterium: Temat


Tytuł :
Enhanced Vasculogenic Capacity Induced by 5-Fluorouracil Chemoresistance in a Gastric Cancer Cell Line.
Autorzy :
Peri S; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy.
Biagioni A; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
Versienti G; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
Andreucci E; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
Staderini F; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy.
Barbato G; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy.
Giovannelli L; Department of Neuroscience, Psychology, Drug Research and Children's Health, University of Florence, Viale Pieraccini, 6-50139 Firenze, Italy.
Coratti F; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy.
Schiavone N; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
Cianchi F; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy.
Papucci L; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
Magnelli L; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 19; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*/drug effects
Drug Resistance, Neoplasm*/genetics
Fluorouracil/*pharmacology
Neovascularization, Pathologic/*chemically induced
Stomach Neoplasms/*blood supply
Stomach Neoplasms/*drug therapy
Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Cisplatin/pharmacology ; Endothelial Cells/drug effects ; Endothelial Cells/pathology ; Fluorouracil/metabolism ; Humans ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/pathology ; Paclitaxel/pharmacology ; Stomach Neoplasms/pathology ; Thalidomide/pharmacology ; Thymidine Phosphorylase/genetics ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance.
Autorzy :
He Y; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Huang C; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.
Cai K; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.
Liu P; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Chen X; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xu YI; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.
Ming Z; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha 410008, China.
Liu Q; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xie Q; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xia X; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha 410008, China.
Sun Y; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Luo J; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.
Wei R; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2021 Jul 05; Vol. 53 (7), pp. 893-902.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*/drug effects
Cell Movement*/radiation effects
Cell Proliferation*/drug effects
Cell Proliferation*/radiation effects
Chemoradiotherapy*
Drug Resistance, Neoplasm*/drug effects
Drug Resistance, Neoplasm*/radiation effects
Radiation Tolerance*/drug effects
Radiation Tolerance*/radiation effects
Tongue Neoplasms*/genetics
Tongue Neoplasms*/metabolism
Tongue Neoplasms*/pathology
Tongue Neoplasms*/therapy
Cisplatin/*pharmacology
DNA Repair Enzymes/*metabolism
Nuclear Proteins/*metabolism
RNA Splicing Factors/*metabolism
Animals ; Cell Line, Tumor ; DNA Repair Enzymes/genetics ; Female ; Humans ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Middle Aged ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Nuclear Proteins/genetics ; RNA Splicing Factors/genetics ; Radiation, Ionizing ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Induction of Cross-resistance to ABCB1 Substrates in Venetoclax-resistant Human Leukemia HL60 Cells.
Autorzy :
Nakayama Y; Department of Pharmaceutics, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Himeji, Japan.
Takara K; Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Himeji, Japan; .; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Hyogo University of Health Sciences, Kobe, Japan.
Minegaki T; Department of Clinical Pharmacy, Kyoto Pharmaceutical University, Kyoto, Japan.
Yamamoto K; Department of Pharmaceutics, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Pharmacy, Kobe University Hospital, Kobe, Japan.
Omura T; Department of Pharmaceutics, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Pharmacy, Kobe University Hospital, Kobe, Japan.
Yano I; Department of Pharmaceutics, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Pharmacy, Kobe University Hospital, Kobe, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Sep; Vol. 41 (9), pp. 4239-4248. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Up-Regulation*
Leukemia, Promyelocytic, Acute/*genetics
ATP Binding Cassette Transporter, Subfamily B/genetics ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Proliferation ; Cell Survival ; Gene Expression Regulation, Neoplastic ; HL-60 Cells ; Humans ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł :
MUSASHI-2 confers resistance to third-generation EGFR-tyrosine kinase inhibitor osimertinib in lung adenocarcinoma.
Autorzy :
Yiming R; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
Takeuchi Y; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
Nishimura T; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
Li M; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
Wang Y; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
Meguro-Horike M; Division of Functional Genomics, Advanced Science Research Center, Kanazawa University, Kanazawa City, Japan.
Kohno T; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Horike SI; Division of Functional Genomics, Advanced Science Research Center, Kanazawa University, Kanazawa City, Japan.
Nakata A; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
Gotoh N; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3810-3821. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Acrylamides/*pharmacology
Adenocarcinoma of Lung/*metabolism
Aniline Compounds/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Gefitinib/*pharmacology
Lung Neoplasms/*metabolism
Protein Kinase Inhibitors/*pharmacology
RNA-Binding Proteins/*metabolism
A549 Cells ; Acrylamides/therapeutic use ; Adenocarcinoma of Lung/pathology ; Aniline Compounds/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cell Survival/genetics ; Drug Resistance, Neoplasm/genetics ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Gefitinib/therapeutic use ; Gene Expression Profiling ; Gene Knockdown Techniques ; Humans ; Lung Neoplasms/pathology ; Mutation ; Nanog Homeobox Protein/metabolism ; Protein Kinase Inhibitors/therapeutic use ; RNA-Binding Proteins/genetics ; Transcriptome ; Transfection
Czasopismo naukowe
Tytuł :
Combined anti-hepatocellular carcinoma therapy inhibit drug-resistance and metastasis via targeting "substance P-hepatic stellate cells-hepatocellular carcinoma" axis.
Autorzy :
Li Z; School of Bioscience and Technology, Weifang Medical University, PR China.
Wang F; School of Bioscience and Technology, Weifang Medical University, PR China.
Li Y; School of Bioscience and Technology, Weifang Medical University, PR China.
Wang X; School of Bioscience and Technology, Weifang Medical University, PR China.
Lu Q; School of Bioscience and Technology, Weifang Medical University, PR China.
Wang D; School of Nursing, Weifang Medical University, PR China.
Qi C; School of Nursing, Weifang Medical University, PR China.
Li C; School of Pharmacy, Weifang Medical University, Weifang, 261053, PR China.
Li Z; School of Pharmacy, Weifang Medical University, Weifang, 261053, PR China.
Lian B; School of Bioscience and Technology, Weifang Medical University, PR China.
Tian G; School of Bioscience and Technology, Weifang Medical University, PR China.
Gao Z; School of Bioscience and Technology, Weifang Medical University, PR China. Electronic address: .
Zhang B; School of Pharmacy, Weifang Medical University, Weifang, 261053, PR China. Electronic address: .
Wu J; School of Bioscience and Technology, Weifang Medical University, PR China. Electronic address: .
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Źródło :
Biomaterials [Biomaterials] 2021 Sep; Vol. 276, pp. 121003. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular*/drug therapy
Drug Resistance, Neoplasm*
Liver Neoplasms*/drug therapy
Antineoplastic Agents/*pharmacology
Animals ; Cell Line, Tumor ; Hepatic Stellate Cells ; Mice ; Substance P ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Pyruvate dehydrogenase kinase 4-mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B-cell lymphoma by affecting the expression of MS4A1/CD20.
Autorzy :
Jiang D; Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, China.; Department of Hematology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Mo Q; Department of Hematology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Sun X; Department of Hematology, The Qinghai Provincial People's Hospital, Xining, China.
Wang X; Department of Hematology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Dong M; Department of Hematology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Zhang G; Department of Hematology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Chen F; Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, China.
Zhao Q; Department of Hematology, The Qinghai Provincial People's Hospital, Xining, China.; Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3585-3597. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, CD20/*metabolism
Antineoplastic Agents, Immunological/*administration & dosage
Cellular Reprogramming/*genetics
Drug Resistance, Neoplasm/*genetics
Glycoproteins/*metabolism
Lymphoma, Large B-Cell, Diffuse/*drug therapy
Lymphoma, Large B-Cell, Diffuse/*metabolism
Pyruvate Dehydrogenase Acetyl-Transferring Kinase/*metabolism
Rituximab/*administration & dosage
Signal Transduction/*genetics
Adolescent ; Adult ; Aged ; Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Drug Resistance, Neoplasm/drug effects ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Male ; Mice ; Middle Aged ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase/genetics ; Transfection ; Treatment Outcome ; Tumor Burden/drug effects ; Tumor Burden/genetics ; Xenograft Model Antitumor Assays ; Young Adult
Czasopismo naukowe
Tytuł :
The Impact of Tumor-associated Macrophages on Chemoresistance via Angiogenesis in Colorectal Cancer.
Autorzy :
Shibutani M; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan; .
Nakao S; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Maeda K; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.; Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan.
Nagahara H; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Kashiwagi S; Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Hirakawa K; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Ohira M; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Sep; Vol. 41 (9), pp. 4447-4453.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Biomarkers, Tumor/*metabolism
Colorectal Neoplasms/*blood supply
Platelet Endothelial Cell Adhesion Molecule-1/*metabolism
Tumor-Associated Macrophages/*metabolism
Adult ; Aged ; Aged, 80 and over ; Cell Line, Tumor ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/surgery ; Epithelial-Mesenchymal Transition ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
P53 Is Involved in Sunitinib Resistance and Poor Progression-free Survival After Sunitinib Treatment of Renal Cell Carcinoma.
Autorzy :
Sekino Y; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; .
Takemoto K; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Murata D; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Babasaki T; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kobatake K; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kitano H; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Ikeda K; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Goto K; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Inoue S; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Hayashi T; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Taniyama D; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Shigeta M; Department of Urology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Kuraoka K; Department of Diagnostic Pathology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Mita K; Department of Urology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan.
Kaneko M; Department of Diagnostic Pathology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan.
Sentani K; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Oue N; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Teishima J; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Sep; Vol. 41 (9), pp. 4287-4294.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Up-Regulation*/drug effects
Carcinoma, Renal Cell/*drug therapy
Imidazoles/*pharmacology
Kidney Neoplasms/*drug therapy
Piperazines/*pharmacology
Sunitinib/*pharmacology
Tumor Suppressor Protein p53/*genetics
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Cell Proliferation/drug effects ; Computer Simulation ; Drug Synergism ; Female ; Gene Knockout Techniques ; Humans ; Kaplan-Meier Estimate ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Male ; Middle Aged ; Progression-Free Survival ; Retrospective Studies ; Treatment Outcome ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
Trametinib overcomes KRAS-G12V-induced osimertinib resistance in a leptomeningeal carcinomatosis model of EGFR-mutant lung cancer.
Autorzy :
Fukuda K; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.; Nano Life Science Institute, Kanazawa University, Kanazawa, Japan.
Otani S; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.; Department of Respiratory Medicine, Kitasato University School of Medicine, Kanagawa, Japan.
Takeuchi S; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.; Nano Life Science Institute, Kanazawa University, Kanazawa, Japan.
Arai S; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Nanjo S; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.; Department of Medicine, Division of Hematology-Oncology, University of California San Francisco, San Francisco, CA, USA.
Tanimoto A; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Nishiyama A; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Naoki K; Department of Respiratory Medicine, Kitasato University School of Medicine, Kanagawa, Japan.
Yano S; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.; Nano Life Science Institute, Kanazawa University, Kanazawa, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3784-3795. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Acrylamides/*administration & dosage
Aniline Compounds/*administration & dosage
Antineoplastic Agents/*administration & dosage
Carcinoma, Non-Small-Cell Lung/*drug therapy
Codon/*genetics
Drug Resistance, Neoplasm/*drug effects
Lung Neoplasms/*drug therapy
Meningeal Carcinomatosis/*drug therapy
Protein Kinase Inhibitors/*administration & dosage
Proto-Oncogene Proteins p21(ras)/*genetics
Pyridones/*administration & dosage
Pyrimidinones/*administration & dosage
Animals ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Drug Resistance, Neoplasm/genetics ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Meningeal Carcinomatosis/genetics ; Meningeal Carcinomatosis/metabolism ; Mice ; Mice, SCID ; Proto-Oncogene Proteins p21(ras)/metabolism ; Pyridones/pharmacology ; Pyrimidinones/pharmacology ; Transfection ; Treatment Outcome ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The BAFF/NFκB axis is crucial to interactions between sorafenib-resistant HCC cells and cancer-associated fibroblasts.
Autorzy :
Gao L; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Morine Y; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Yamada S; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Saito Y; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Ikemoto T; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Tokuda K; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Miyazaki K; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Okikawa S; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Takasu C; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Shimada M; Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3545-3554. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
B-Cell Activating Factor/*metabolism
Cancer-Associated Fibroblasts/*metabolism
Carcinoma, Hepatocellular/*metabolism
Cell Communication/*genetics
Drug Resistance, Neoplasm/*genetics
Liver Neoplasms/*metabolism
NF-kappa B/*metabolism
Signal Transduction/*genetics
Sorafenib/*pharmacology
B-Cell Activating Factor/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Movement/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Coculture Techniques ; Drug Resistance, Neoplasm/drug effects ; Gene Knockdown Techniques ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Transfection
Czasopismo naukowe
Tytuł :
Heparanase confers temozolomide resistance by regulation of exosome secretion and circular RNA composition in glioma.
Autorzy :
Si J; Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Li W; Department of Physiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Li X; Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Cao L; Department of Perioperative Research Centre of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Chen Z; Department of Perioperative Research Centre of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Jiang Z; Department of Perioperative Research Centre of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3491-3506. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Alkylating/*administration & dosage
Brain Neoplasms/*drug therapy
Drug Resistance, Neoplasm/*genetics
Exosomes/*metabolism
Glioma/*drug therapy
Glucuronidase/*metabolism
RNA, Circular/*metabolism
Secretory Pathway/*genetics
Temozolomide/*administration & dosage
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Brain Neoplasms/blood ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Drug Resistance, Neoplasm/drug effects ; Female ; Glioma/blood ; Glioma/pathology ; Glucuronidase/genetics ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; RNA, Circular/genetics ; Transfection ; Treatment Outcome ; Tumor Burden/drug effects ; Tumor Burden/genetics ; Up-Regulation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Molecular Mechanisms of Chemoresistance Induced by Cisplatin in NSCLC Cancer Therapy.
Autorzy :
Kryczka J; Department of Biomedicine and Genetics, Medical University of Lodz, 92-213 Lodz, Poland.
Kryczka J; Institute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, Poland.
Czarnecka-Chrebelska KH; Department of Biomedicine and Genetics, Medical University of Lodz, 92-213 Lodz, Poland.
Brzeziańska-Lasota E; Department of Biomedicine and Genetics, Medical University of Lodz, 92-213 Lodz, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Resistance, Neoplasm*
Antineoplastic Agents/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Cisplatin/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Lung Neoplasms/*drug therapy
Animals ; Carcinoma, Non-Small-Cell Lung/pathology ; Humans ; Lung Neoplasms/pathology ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Interaction between SCP3 and JAB1 Confers Cancer Therapeutic Resistance and Stem-like Properties through EGF Expression.
Autorzy :
Oh SJ; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea.; Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 02841, Korea.
Noh KH; Gene Therapy Research Unit, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Song KH; Department of Cell Biology, Daegu Catholic University School of Medicine, Daegu 42472, Korea.
Kim TW; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea.; Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 02841, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 17; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
COP9 Signalosome Complex/*metabolism
Cell Cycle Proteins/*metabolism
DNA-Binding Proteins/*metabolism
Epidermal Growth Factor/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Neoplastic Stem Cells/*drug effects
Peptide Hydrolases/*metabolism
Uterine Cervical Neoplasms/*drug therapy
COP9 Signalosome Complex/genetics ; Cell Cycle Proteins/genetics ; DNA-Binding Proteins/genetics ; Epidermal Growth Factor/genetics ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Mutation ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Peptide Hydrolases/genetics ; Phosphorylation ; Protein Interaction Domains and Motifs ; Signal Transduction ; Tumor Cells, Cultured ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Disruption of Cytosolic Folate Integrity Aggravates Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Modulates Metastatic Properties in Non-Small-Cell Lung Cancer Cells.
Autorzy :
Shen PW; Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei 112, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Ho CT; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Hsiao SH; Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan.
Chou YT; Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan.
Chang YC; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei 110, Taiwan.; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei 110, Taiwan.
Liu JJ; School of Medical Laboratory Science and Biotechnology, Taipei Medical University, Taipei 110, Taiwan.; Ph.D. Program in Medical Biotechnology, Taipei Medical University, Taipei 110, Taiwan.; Ph.D. Program in Biotechnology Research and Development, Taipei Medical University, Taipei 110, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 17; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Carcinoma, Non-Small-Cell Lung/*secondary
Cytoplasm/*metabolism
Folic Acid/*metabolism
Lung Neoplasms/*pathology
Protein Kinase Inhibitors/*pharmacology
Apoptosis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Movement ; Cell Proliferation ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Mutation ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Hypomethylated RRBP1 Potentiates Tumor Malignancy and Chemoresistance in Upper Tract Urothelial Carcinoma.
Autorzy :
Luo HL; Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Liu HY; Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Chang YL; Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Sung MT; Department of Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Chen PY; Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Su YL; Department of Hematology and Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Huang CC; Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Peng JM; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 16; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Drug Resistance, Neoplasm*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Carrier Proteins/*metabolism
Urinary Bladder Neoplasms/*drug therapy
Urinary Bladder Neoplasms/*pathology
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Carrier Proteins/genetics ; Cell Proliferation ; Gene Expression Profiling ; Humans ; Mice ; Prognosis ; Survival Rate ; Tumor Cells, Cultured ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines.
Autorzy :
Quah SY; Pharmacotherapeutics Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Wong CC; Pharmacotherapeutics Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Wong HC; Pharmacotherapeutics Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Ho KL; Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Abdul Manan N; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Deb PK; Faculty of Pharmacy, P.O.BOX (1), Philadelphia University, 19392 Amman, Jordan.
Sagineedu SR; Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 57000 Kuala Lumpur, Malaysia.
Stanslas J; Pharmacotherapeutics Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Aug 15; Vol. 425, pp. 115605. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Diterpenes/*pharmacology
Protein Array Analysis/*methods
Antineoplastic Agents/pharmacology ; Cell Survival ; Colonic Neoplasms ; Gene Expression Regulation, Neoplastic/drug effects ; HCT116 Cells ; Humans ; Male ; PC-3 Cells ; Prostatic Neoplasms
Czasopismo naukowe
Tytuł :
Nanotherapeutic approach to tackle chemotherapeutic resistance of cancer stem cells.
Autorzy :
Oliveira BSA; Undergradute student, Department of Medicine, Federal University of Juiz de Fora, Governador Valadares, MG 35032-620, Brazil.
de Assis ACC; Undergradute student, Department of Medicine, Federal University of Juiz de Fora, Governador Valadares, MG 35032-620, Brazil.
Souza NM; Undergradute student, Department of Medicine, Federal University of Juiz de Fora, Governador Valadares, MG 35032-620, Brazil.
Ferreira LFR; Graduate Program in Process Engineering, Tiradentes University (UNIT), Av. Murilo Dantas, 300, Farolândia, 49032-490 Aracaju, Sergipe, Brazil; Institute of Technology and Research (ITP), Tiradentes University (UNIT), Av. Murilo Dantas, 300, Farolândia, 49032-490 Aracaju, Sergipe, Brazil.
Soriano RN; Division of Physiology and Biophysics, Department of Basic Life Sciences, Federal University of Juiz de Fora, Governador Valadares, MG 35010-177, Brazil.
Bilal M; School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, China. Electronic address: .
Iqbal HMN; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 15; Vol. 279, pp. 119667. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Resistance, Neoplasm*
Antineoplastic Agents/*therapeutic use
Nanoparticles/*administration & dosage
Neoplasms/*drug therapy
Neoplastic Stem Cells/*drug effects
Animals ; Antineoplastic Agents/chemistry ; Humans ; Nanoparticles/chemistry ; Neoplasms/pathology ; Neoplastic Stem Cells/pathology
Czasopismo naukowe
Tytuł :
SWIM domain protein ZSWIM4 is required for JAK2 inhibition resistance in breast cancer.
Autorzy :
Gong K; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Pathology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, Guangdong, China.
Song K; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Pathology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, Guangdong, China.
Zhu Z; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Pathology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, Guangdong, China.
Xiang Q; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Pathology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, Guangdong, China.
Wang K; Department of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou 510080, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China. Electronic address: .
Shi J; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Pathology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Oncology, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue, Guangzhou 510282, Guangdong, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 15; Vol. 279, pp. 119696. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Gene Expression Regulation, Neoplastic*
Breast Neoplasms/*drug therapy
DNA-Binding Proteins/*metabolism
Janus Kinase 2/*antagonists & inhibitors
Pyrimidines/*pharmacology
Sulfonamides/*pharmacology
Animals ; Apoptosis ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; DNA-Binding Proteins/genetics ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Autorzy :
Yang Z; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xu G; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang B; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu Y; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang L; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing T; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tang M; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xu X; Shanghai Jiao Tong University School of Biomedical Engineering, Shanghai, China.
Jiao K; Shanghai Jiao Tong University School of Biomedical Engineering, Shanghai, China.
Xiang L; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fu Y; Department of Thoracic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Tang D; Department of Pathology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhang X; Affiliated Cancer Hospital and Institute, Guangzhou Medical University, Guangzhou, China.
Jin W; Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Zhuang G; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhao X; Department of Thoracic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. .
Liu Y; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 11; Vol. 12 (1), pp. 4852. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Lung Neoplasms/*therapy
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Tumor Microenvironment/*immunology
Ubiquitin Thiolesterase/*metabolism
Animals ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/therapy ; Chemokines/metabolism ; Down-Regulation ; Humans ; Immune Tolerance ; Immunotherapy ; Lung Neoplasms/immunology ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Protein Phosphatase 2C/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Ubiquitin Thiolesterase/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
High Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Correlating the Metabolic Changes of Lactate, Pyruvate and L-Glutamine with Induced Tamoxifen Resistant MCF-7 Cell Line Potential Molecular Changes.
Autorzy :
Alhusban AA; Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Albustanji S; Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Hamadneh LA; Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Shallan AI; Department of Analytical Chemistry, Faculty of Pharmacy, Helwan University, Cairo 11435, Egypt.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 10; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*/drug effects
Tandem Mass Spectrometry*
Glutamine/*metabolism
Lactic Acid/*metabolism
Tamoxifen/*pharmacology
Calibration ; Cell Count ; Cell Shape/drug effects ; Chromatography, High Pressure Liquid ; Humans ; MCF-7 Cells ; Pyruvic Acid/metabolism ; Reproducibility of Results
Czasopismo naukowe

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