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Wyszukujesz frazę ""Drug Synergism"" wg kryterium: Temat


Tytuł :
Combinations of a full and partial agonist: Experimental evidence of curved isoboles.
Autorzy :
Ezechiáš M; The Laboratory of Environmental Biotechnology, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, Prague, 142 20, Czech Republic. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 10; Vol. 350, pp. 22-29. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Partial Agonism*
Drug Synergism*
Drug Interactions/*physiology
Dose-Response Relationship, Drug ; Models, Theoretical
Czasopismo naukowe
Tytuł :
Synergistic Effects of Venetoclax and Daratumumab on Antibody-Dependent Cell-Mediated Natural Killer Cytotoxicity in Multiple Myeloma.
Autorzy :
Nakamura A; Department of Internal Medicine, Division of Hematology, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan.
Suzuki S; Research Creation Support Center, Aichi Medical University, Nagakute 480-1195, Japan.; Department of Tumor Immunology, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan.
Kanasugi J; Department of Internal Medicine, Division of Hematology, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan.
Ejiri M; Department of Pharmacy, University Hospital, Aichi Medical University, Nagakute 480-1195, Japan.
Hanamura I; Department of Internal Medicine, Division of Hematology, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan.
Ueda R; Department of Tumor Immunology, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan.
Seto M; Department of Internal Medicine, Division of Hematology, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan.
Takami A; Department of Internal Medicine, Division of Hematology, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 05; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Antibody-Dependent Cell Cytotoxicity/*drug effects
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Killer Cells, Natural/*drug effects
Killer Cells, Natural/*pathology
Multiple Myeloma/*pathology
Antibodies, Monoclonal/administration & dosage ; Apoptosis ; Bridged Bicyclo Compounds, Heterocyclic/administration & dosage ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Killer Cells, Natural/metabolism ; Multiple Myeloma/drug therapy ; Multiple Myeloma/metabolism ; Sulfonamides/administration & dosage ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Synergistic Growth Inhibition of HT-29 Colon and MCF-7 Breast Cancer Cells with Simultaneous and Sequential Combinations of Antineoplastics and CNS Drugs.
Autorzy :
Duarte D; OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.; Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Cardoso A; NeuroGen Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.; Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
Vale N; OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.; Department of Community Medicine, Health Information and Decision (MEDCIDS), Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 10; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 10.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Antipsychotic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Colonic Neoplasms/*drug therapy
Apoptosis ; Breast Neoplasms/pathology ; Cell Proliferation ; Colonic Neoplasms/pathology ; Drug Therapy, Combination ; Female ; Fluorouracil/administration & dosage ; Humans ; Paclitaxel/administration & dosage ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Epithelial-to-Mesenchymal Transition Is Not a Major Modulating Factor in the Cytotoxic Response to Natural Products in Cancer Cell Lines.
Autorzy :
Kucukkaraduman B; Department of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Turkey.
Cicek EG; Department of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Turkey.
Akbar MW; Department of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Turkey.
Demirkol Canli S; Molecular Pathology Application and Research Center, Hacettepe University, Ankara 06100, Turkey.
Vural B; Department of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul 34093, Turkey.
Gure AO; Department of Medical Biology, Acibadem University, Istanbul 34684, Turkey.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 27; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Epithelial-Mesenchymal Transition*
Antineoplastic Agents/*pharmacology
Biological Products/*pharmacology
Breast Neoplasms/*pathology
Colonic Neoplasms/*pathology
Pancreatic Neoplasms/*pathology
Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Movement ; Cell Proliferation ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Female ; Humans ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
New Insight into the Chemical Composition, Antimicrobial and Synergistic Effects of the Moroccan Endemic Thymus atlanticus (Ball) Roussine Essential Oil in Combination with Conventional Antibiotics.
Autorzy :
Nafis A; Microbiology, Health and Environment Team, Faculty of Sciences, Chouaïb Doukkali University, El Jadida 24000, Morocco.; Laboratory of Microbial Biotechnologies, Agrosciences and Environment, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech 40000, Morocco.
Iriti M; Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy.
Ouchari L; Moroccan Coordinated Collection of Microorganisms (CCMM), National Center for Scientific and Technical Research (CNRST), P.O. Box 8027, Rabat 10102, Morocco.
El Otmani F; Microbiology, Health and Environment Team, Faculty of Sciences, Chouaïb Doukkali University, El Jadida 24000, Morocco.
Marraiki N; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Elgorban AM; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Syed A; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Mezrioui N; Laboratory of Microbial Biotechnologies, Agrosciences and Environment, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech 40000, Morocco.
Hassani L; Laboratory of Microbial Biotechnologies, Agrosciences and Environment, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech 40000, Morocco.
Custódio L; Center of Marine Sciences, Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 27; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Anti-Bacterial Agents/*pharmacology
Antifungal Agents/*pharmacology
Bacteria/*drug effects
Candida albicans/*drug effects
Oils, Volatile/*pharmacology
Thymus Plant/*chemistry
Morocco
Czasopismo naukowe
Tytuł :
Effect of Cold Atmospheric Plasma Jet Associated to Polyene Antifungals on Candida albicans Biofilms.
Autorzy :
Leite LDP; Science Applied to Oral Health, Graduate Program of Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos 12245-000, Brazil.
Oliveira MAC; Oral Biopathology, Graduate Program of Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos 12245-000, Brazil.
Vegian MRDC; Science Applied to Oral Health, Graduate Program of Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos 12245-000, Brazil.
Sampaio ADG; Science Applied to Oral Health, Graduate Program of Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos 12245-000, Brazil.
Nishime TMC; Leibniz Institute for Plasma Science and Technology, 17489 Greifswald, Germany.
Kostov KG; Department of Physics, Guaratinguetá Faculty of Engineering, São Paulo State University (Unesp), Guaratinguetá 12516-410, Brazil.
Koga-Ito CY; Science Applied to Oral Health, Graduate Program of Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos 12245-000, Brazil.; Oral Biopathology, Graduate Program of Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos 12245-000, Brazil.; Department of Environment Engineering, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos 12247-016, Brazil.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 25; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Amphotericin B/*pharmacology
Antifungal Agents/*pharmacology
Biofilms/*drug effects
Candida albicans/*drug effects
Nystatin/*pharmacology
Plasma Gases/*pharmacology
Biofilms/growth & development ; Candida albicans/growth & development
Czasopismo naukowe
Tytuł :
STL1, a New AKT Inhibitor, Synergizes with Flavonoid Quercetin in Enhancing Cell Death in A Chronic Lymphocytic Leukemia Cell Line.
Autorzy :
Cervellera C; National Research Council, Institute of Food Sciences, 83100 Avellino, Italy.
Russo M; National Research Council, Institute of Food Sciences, 83100 Avellino, Italy.
Dotolo S; National Research Council, Institute of Food Sciences, 83100 Avellino, Italy.
Facchiano A; National Research Council, Institute of Food Sciences, 83100 Avellino, Italy.
Russo GL; National Research Council, Institute of Food Sciences, 83100 Avellino, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 25; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Biomarkers, Tumor/*metabolism
Gene Expression Regulation, Neoplastic/*drug effects
Leukemia, Lymphocytic, Chronic, B-Cell/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
Quercetin/*pharmacology
Antioxidants/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
PARP inhibition in UV-associated angiosarcoma preclinical models.
Autorzy :
Weidema ME; Department of Medical Oncology, Radboud University Medical Center, Internal Postal Code 452, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. .
Desar IME; Department of Medical Oncology, Radboud University Medical Center, Internal Postal Code 452, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Hillebrandt-Roeffen MHS; Department of Medical Oncology, Radboud University Medical Center, Internal Postal Code 452, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
van Erp AEM; Department of Medical Oncology, Radboud University Medical Center, Internal Postal Code 452, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Masuzawa M; Department of Regulation Biochemistry, Kitasato University School of Allied Sciences, Sagamihara, Japan.
Flucke UE; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
van der Graaf WTA; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Versleijen-Jonkers YMH; Department of Medical Oncology, Radboud University Medical Center, Internal Postal Code 452, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
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Corporate Authors :
PALGA-group
Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Sep; Vol. 147 (9), pp. 2579-2590. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Ultraviolet Rays*
Hemangiosarcoma/*drug therapy
Nuclear Proteins/*metabolism
Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Temozolomide/*pharmacology
Antineoplastic Agents, Alkylating/pharmacology ; Apoptosis ; Cell Proliferation ; Drug Combinations ; Drug Evaluation, Preclinical ; Hemangiosarcoma/etiology ; Hemangiosarcoma/pathology ; Humans ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Prognosis ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
A metal-free salalen ligand with anti-tumor and synergistic activity in resistant leukemia and solid tumor cells via mitochondrial pathway.
Autorzy :
Hopff SM; Department of Pediatric Hematology/Oncology, Municipal Clinics of Cologne, Children's Hospital of the City Cologne, Amsterdamer Straße 59, 50735, Cologne, Germany. .
Wang Q; Department of Chemistry, University of Cologne, Greinstraße 4, 50939, Cologne, Germany.
Frias C; Department of Pediatric Hematology/Oncology, Municipal Clinics of Cologne, Children's Hospital of the City Cologne, Amsterdamer Straße 59, 50735, Cologne, Germany.
Ahrweiler M; Department of Pediatric Hematology/Oncology, Municipal Clinics of Cologne, Children's Hospital of the City Cologne, Amsterdamer Straße 59, 50735, Cologne, Germany.
Wilke N; Department of Pediatric Hematology/Oncology, Municipal Clinics of Cologne, Children's Hospital of the City Cologne, Amsterdamer Straße 59, 50735, Cologne, Germany.
Wilke N; Department of Pediatric Hematology/Oncology, Municipal Clinics of Cologne, Children's Hospital of the City Cologne, Amsterdamer Straße 59, 50735, Cologne, Germany.
Berkessel A; Department of Chemistry, University of Cologne, Greinstraße 4, 50939, Cologne, Germany.
Prokop A; Department of Pediatric Hematology/Oncology, Municipal Clinics of Cologne, Children's Hospital of the City Cologne, Amsterdamer Straße 59, 50735, Cologne, Germany.; Department of Pediatric Hematology/Oncology, Helios Clinic Schwerin, Wismarsche Straße 393-397, 19055, Schwerin, Germany.; Medical School Hamburg (MSH), University of Applied Sciences and Medical University, Am Kaiserkai 1, 20457, Hamburg, Germany.
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Sep; Vol. 147 (9), pp. 2591-2607. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Antineoplastic Agents/*pharmacology
Drug Resistance, Multiple/*drug effects
Drug Resistance, Neoplasm/*drug effects
Leukemia/*drug therapy
Mitochondria/*drug effects
Neoplasms/*drug therapy
Apoptosis ; Cell Proliferation ; Cisplatin/pharmacology ; Humans ; Leukemia/metabolism ; Leukemia/pathology ; Ligands ; Mitochondria/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Single and mixed exposure to cadmium and mercury in Drosophila melanogaster: Molecular responses and impact on post-embryonic development.
Autorzy :
Frat L; Syndicat Intercommunal pour l'Assainissement de la Région de Pontoise (SIARP), 95000 Pontoise, France; Sorbonne Université, INRA, CNRS, IRD, UPEC, Institut d'Ecologie et des Sciences de l'Environnement de Paris (iEES-Paris), F75005 Paris, France.
Chertemps T; Sorbonne Université, INRA, CNRS, IRD, UPEC, Institut d'Ecologie et des Sciences de l'Environnement de Paris (iEES-Paris), F75005 Paris, France.
Pesce E; Sorbonne Université, INRA, CNRS, IRD, UPEC, Institut d'Ecologie et des Sciences de l'Environnement de Paris (iEES-Paris), F75005 Paris, France.
Bozzolan F; Sorbonne Université, INRA, CNRS, IRD, UPEC, Institut d'Ecologie et des Sciences de l'Environnement de Paris (iEES-Paris), F75005 Paris, France.
Dacher M; Sorbonne Université, INRA, CNRS, IRD, UPEC, Institut d'Ecologie et des Sciences de l'Environnement de Paris (iEES-Paris), F75005 Paris, France; Sorbonne Université, INRA, CNRS, IRD, UPEC, Institut d'Ecologie et des Sciences de l'Environnement de Paris (iEES-Paris), 78026 Versailles, France.
Planelló R; Biology and Environmental Toxicology Group, Faculty of Sciences, Universidad Nacional de Educación a Distancia (UNED), Paseo de la Senda del Rey 9, 28040 Madrid, Spain.
Herrero O; Biology and Environmental Toxicology Group, Faculty of Sciences, Universidad Nacional de Educación a Distancia (UNED), Paseo de la Senda del Rey 9, 28040 Madrid, Spain.
Llorente L; Biology and Environmental Toxicology Group, Faculty of Sciences, Universidad Nacional de Educación a Distancia (UNED), Paseo de la Senda del Rey 9, 28040 Madrid, Spain.
Moers D; Syndicat Intercommunal pour l'Assainissement de la Région de Pontoise (SIARP), 95000 Pontoise, France.
Siaussat D; Sorbonne Université, INRA, CNRS, IRD, UPEC, Institut d'Ecologie et des Sciences de l'Environnement de Paris (iEES-Paris), F75005 Paris, France. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Sep 01; Vol. 220, pp. 112377. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Cadmium/*toxicity
Drosophila melanogaster/*drug effects
Environmental Exposure/*adverse effects
Environmental Pollutants/*toxicity
Mercury/*toxicity
Animals ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/metabolism ; Embryonic Development ; Environmental Exposure/analysis ; Gene Expression Regulation/drug effects ; Hormones/metabolism ; Metals, Heavy/toxicity ; Oxidative Stress ; Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Molecular Iodine/Cyclophosphamide Synergism on Chemoresistant Neuroblastoma Models.
Autorzy :
Álvarez-León W; Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM) Juriquilla, Querétaro 76230, Mexico.
Mendieta I; Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM) Juriquilla, Querétaro 76230, Mexico.
Delgado-González E; Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM) Juriquilla, Querétaro 76230, Mexico.
Anguiano B; Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM) Juriquilla, Querétaro 76230, Mexico.
Aceves C; Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM) Juriquilla, Querétaro 76230, Mexico.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 19; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Biomarkers, Tumor/*metabolism
Cyclophosphamide/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Iodine/*pharmacology
Neuroblastoma/*drug therapy
Animals ; Anti-Infective Agents, Local/pharmacology ; Antineoplastic Agents, Alkylating/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Differentiation ; Cell Proliferation ; Drug Therapy, Combination ; Humans ; Male ; Mice ; Mice, Nude ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Synergistic efficacy of curcumin and anti-programmed cell death-1 in hepatocellular carcinoma.
Autorzy :
Guo L; Department of Infection, Qingdao No. 6 People's Hospital, Qingdao 266033, PR China.
Li H; Department of Dermatology, Qingdao No. 6 People's Hospital, Qingdao 266033, PR China.
Fan T; Department of Infection, Qingdao No. 6 People's Hospital, Qingdao 266033, PR China.
Ma Y; Department of Infection, Qingdao No. 6 People's Hospital, Qingdao 266033, PR China. Electronic address: .
Wang L; Department of Hepatology, Qingdao No. 6 People's Hospital, Qingdao 266033, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 15; Vol. 279, pp. 119359. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Antineoplastic Agents, Immunological/*pharmacology
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Curcumin/*pharmacology
Liver Neoplasms/*drug therapy
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation ; E1A-Associated p300 Protein/genetics ; E1A-Associated p300 Protein/metabolism ; Female ; Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism ; Tumor Cells, Cultured ; Tumor Microenvironment ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Metabolomic Identification of Anticancer Metabolites of Australian Propolis and Proteomic Elucidation of Its Synergistic Mechanisms with Doxorubicin in the MCF7 Cells.
Autorzy :
Alsherbiny MA; NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia.; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Bhuyan DJ; NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia.
Radwan I; Faculty of Science and Technology, University of Canberra, Canberra, ACT 2617, Australia.
Chang D; NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia.
Li CG; NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 22; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Antibiotics, Antineoplastic/*pharmacology
Breast Neoplasms/*drug therapy
Doxorubicin/*pharmacology
Metabolome/*drug effects
Propolis/*pharmacology
Proteome/*drug effects
Anti-Infective Agents/pharmacology ; Apoptosis ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Drug Therapy, Combination ; Female ; Humans ; MCF-7 Cells
Czasopismo naukowe
Tytuł :
Synergistic effect of docosahexaenoic acid or conjugated linoleic acid with caffeic acid on ameliorating oxidative stress of HepG2 cells.
Autorzy :
Liu Y; College of Food Science, Shenyang Agricultural University, Shenyang, P.R. China.
Bian Y; College of Food Science, Shenyang Agricultural University, Shenyang, P.R. China.
Luo X; College of Food Science, Shenyang Agricultural University, Shenyang, P.R. China.
Wang C; College of Food Science, Shenyang Agricultural University, Shenyang, P.R. China.
Mu D; College of Food Science, Shenyang Agricultural University, Shenyang, P.R. China.
Pan G; College of Food Science, Shenyang Agricultural University, Shenyang, P.R. China.
Wu J; College of Food Science, Shenyang Agricultural University, Shenyang, P.R. China.
Shi H; College of Food Science, Shenyang Agricultural University, Shenyang, P.R. China.
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Źródło :
Journal of food science [J Food Sci] 2021 Jul; Vol. 86 (7), pp. 3240-3251. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Caffeic Acids/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Docosahexaenoic Acids/*pharmacology
Linoleic Acids, Conjugated/*pharmacology
Liver Neoplasms/*drug therapy
Oxidative Stress/*drug effects
Drug Therapy, Combination ; Hep G2 Cells ; Humans
Czasopismo naukowe
Tytuł :
Cooperativity between β-agonists and c-Abl inhibitors in regulating airway smooth muscle relaxation.
Autorzy :
Nayak AP; Department of Medicine, Pulmonary and Critical Care Medicine, Center for Translational Medicine, Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, USA.
Lim JM; Department of Medicine, Pulmonary and Critical Care Medicine, Center for Translational Medicine, Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, USA.
Arbel E; Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Wang R; Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Villalba DR; Department of Medicine, Pulmonary and Critical Care Medicine, Center for Translational Medicine, Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, USA.
Nguyen TL; Department of Medicine, Pulmonary and Critical Care Medicine, Center for Translational Medicine, Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, USA.
Schaible N; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Krishnan R; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Tang DD; Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Penn RB; Department of Medicine, Pulmonary and Critical Care Medicine, Center for Translational Medicine, Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Jul; Vol. 35 (7), pp. e21674.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Drug Synergism*
Muscle Contraction*
Muscle Relaxation*
Adrenergic beta-Agonists/*pharmacology
Muscle, Smooth/*physiology
Proto-Oncogene Proteins c-abl/*antagonists & inhibitors
Trachea/*physiology
Actin Cytoskeleton/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Benzamides/pharmacology ; Humans ; Imatinib Mesylate/pharmacology ; Isoproterenol/pharmacology ; Mice ; Mice, Inbred C57BL ; Muscle, Smooth/cytology ; Muscle, Smooth/drug effects ; Pyrimidines/pharmacology ; Signal Transduction ; Trachea/cytology ; Trachea/drug effects
Czasopismo naukowe
Tytuł :
PRMT5 Selective Inhibitor Enhances Therapeutic Efficacy of Cisplatin in Lung Cancer Cells.
Autorzy :
Bajbouj K; College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates.
Ramakrishnan RK; College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates.
Saber-Ayad M; College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates.; College of Medicine, Cairo University, Cairo 11956, Egypt.
Omar HA; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates.; College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates.
Saheb Sharif-Askari N; College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates.
Shafarin J; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates.
Elmoselhi AB; College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Ihmaid A; College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
AlHaj Ali S; College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
Alalool A; College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
Abdullah R; College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
Hamid Q; College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates.; Meakins-Christie Laboratories, Research Institute of the McGill University Health Center, Montreal, QC H4A 3J1, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 07; Vol. 22 (11). Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Antineoplastic Agents/*pharmacology
Cisplatin/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Lung Neoplasms/*drug therapy
Naphthalenesulfonates/*pharmacology
Protein-Arginine N-Methyltransferases/*antagonists & inhibitors
Urea/*analogs & derivatives
Apoptosis ; Cell Cycle ; Cell Proliferation ; Enzyme Inhibitors/pharmacology ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Protein-Arginine N-Methyltransferases/genetics ; Protein-Arginine N-Methyltransferases/metabolism ; Tumor Cells, Cultured ; Urea/pharmacology
Czasopismo naukowe
Tytuł :
A novel method of screening combinations of angiostatics identifies bevacizumab and temsirolimus as synergistic inhibitors of glioma-induced angiogenesis.
Autorzy :
Dorrell MI; Department of Biology, Point Loma Nazarene University, San Diego, CA, United States of America.
Kast-Woelbern HR; Department of Biology, Point Loma Nazarene University, San Diego, CA, United States of America.
Botts RT; Department of Mathematical, Information, and Computer Sciences, Point Loma Nazarene University, San Diego, CA, United States of America.
Bravo SA; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Tremblay JR; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Giles S; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Wada JF; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Alexander M; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Garcia E; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.; Department of Biology, Dr. Heidi R. Kast-Woelbern's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Villegas G; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Booth CB; Department of Mathematical, Information, and Computer Sciences, Dr. Ryan Bott's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Purington KJ; Department of Mathematical, Information, and Computer Sciences, Dr. Ryan Bott's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Everett HM; Department of Mathematical, Information, and Computer Sciences, Dr. Ryan Bott's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Siles EN; Department of Mathematical, Information, and Computer Sciences, Dr. Ryan Bott's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Wheelock M; Department of Mathematical, Information, and Computer Sciences, Dr. Ryan Bott's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Silva JA; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.; Department of Biology, Dr. Heidi R. Kast-Woelbern's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Fortin BM; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.; Department of Biology, Dr. Heidi R. Kast-Woelbern's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Lowey CA; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.; Department of Biology, Dr. Heidi R. Kast-Woelbern's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Hale AL; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.; Department of Biology, Dr. Heidi R. Kast-Woelbern's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Kurz TL; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Rusing JC; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Goral DM; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Thompson P; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Johnson AM; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Elson DJ; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Tadros R; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.; Department of Biology, Dr. Heidi R. Kast-Woelbern's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Gillette CE; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.; Department of Biology, Dr. Heidi R. Kast-Woelbern's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Coopwood C; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.; Department of Biology, Dr. Heidi R. Kast-Woelbern's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Rausch AL; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.; Department of Biology, Dr. Heidi R. Kast-Woelbern's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
Snowbarger JM; Department of Biology, Dr. Michael Dorrell's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.; Department of Biology, Dr. Heidi R. Kast-Woelbern's Lab, Point Loma Nazarene University, San Diego, CA, United States of America.
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Źródło :
PloS one [PLoS One] 2021 Jun 02; Vol. 16 (6), pp. e0252233. Date of Electronic Publication: 2021 Jun 02 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Synergism*
Angiogenesis Inhibitors/*pharmacology
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Chorioallantoic Membrane/*drug effects
Drug Screening Assays, Antitumor/*methods
Glioblastoma/*drug therapy
Neovascularization, Pathologic/*drug therapy
Animals ; Bevacizumab/administration & dosage ; Chickens ; Chorioallantoic Membrane/pathology ; Glioblastoma/blood supply ; Glioblastoma/pathology ; Humans ; Neovascularization, Pathologic/pathology ; Rats ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway.
Autorzy :
Huang J; Mathematical Engineering Academy of Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Liu C; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Duan S; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China; Shaoguan Institute of Danxia Dendrobium Officinale, Shaoguan, China.
Lin J; Mathematical Engineering Academy of Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Luo Y; Department of Pharmacy, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Tao S; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xing S; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhang X; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Du H; Department of Biochemistry and Molecular Biology, Guangzhou University of Chinese Medicine, Guangzhou, China; The Research Center of Basic Integrative Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wang H; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Huang C; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wei G; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jun 01; Vol. 274, pp. 119354. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Synergism*
Bibenzyls/*pharmacology
Breast Neoplasms/*drug therapy
Cisplatin/*pharmacology
Guaiacol/*analogs & derivatives
Phosphatidylinositol 3-Kinases/*chemistry
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
TOR Serine-Threonine Kinases/*antagonists & inhibitors
Antineoplastic Agents/pharmacology ; Apoptosis ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Guaiacol/pharmacology ; Humans ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells.
Autorzy :
O'Connell CE; National Institute of Child Health and Human Development, NIH, Bethesda, Maryland.
Vassilev A; National Institute of Child Health and Human Development, NIH, Bethesda, Maryland. .
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Źródło :
Cancer research [Cancer Res] 2021 Jun 01; Vol. 81 (11), pp. 2903-2917. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Autophagy*
Drug Synergism*
Colorectal Neoplasms/*drug therapy
Gene Expression Regulation, Neoplastic/*drug effects
Imidazoles/*pharmacology
Phosphatidylinositol 3-Kinases/*chemistry
Pyridines/*pharmacology
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Animals ; Apoptosis ; Cell Proliferation ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Humans ; Mice ; Mice, Nude ; Phosphorylation ; Proteolysis ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Targeted dual inhibition of c-Met/VEGFR2 signalling by foretinib improves antitumour effects of nanoparticle paclitaxel in gastric cancer models.
Autorzy :
Grojean M; Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.
Schwarz MA; Department of Pediatrics, Indiana University School of Medicine, South Bend, IN, USA.; Harper Cancer Research Institute, University of Notre Dame, South Bend, IN, USA.
Schwarz JR; Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.
Hassan S; Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.; Harper Cancer Research Institute, University of Notre Dame, South Bend, IN, USA.
von Holzen U; Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.; Harper Cancer Research Institute, University of Notre Dame, South Bend, IN, USA.; Goshen Center for Cancer Care, Goshen, IN, USA.; University of Basel, Basel, Switzerland.
Zhang C; Department of Gastrointestinal Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Schwarz RE; Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.; Harper Cancer Research Institute, University of Notre Dame, South Bend, IN, USA.; Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; University of Buffalo, Buffalo, NY, USA.
Awasthi N; Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.; Harper Cancer Research Institute, University of Notre Dame, South Bend, IN, USA.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2021 Jun; Vol. 25 (11), pp. 4950-4961. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Synergism*
Anilides/*pharmacology
Nanoparticles/*administration & dosage
Paclitaxel/*pharmacology
Proto-Oncogene Proteins c-met/*antagonists & inhibitors
Quinolines/*pharmacology
Stomach Neoplasms/*drug therapy
Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors
Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis ; Cell Proliferation ; Drug Combinations ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Nanoparticles/chemistry ; Prognosis ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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