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Tytuł:
In-Silico Identification of Novel Pharmacological Synergisms: The Trabectedin Case.
Autorzy:
Mannarino L; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milan, Italy.; Laboratory of Cancer Pharmacology, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy.
Ravasio N; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, 20133 Milan, Italy.
D'Incalci M; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milan, Italy.; Laboratory of Cancer Pharmacology, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy.
Marchini S; Laboratory of Cancer Pharmacology, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy.
Masseroli M; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, 20133 Milan, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 08; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Tetrahydroisoquinolines*/pharmacology
Antineoplastic Agents*
Trabectedin/pharmacology ; Trabectedin/therapeutic use ; Dioxoles/pharmacology ; Drug Synergism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MFSynDCP: multi-source feature collaborative interactive learning for drug combination synergy prediction.
Autorzy:
Dong, Yunyun (AUTHOR)
Chang, Yunqing (AUTHOR)
Wang, Yuxiang (AUTHOR)
Han, Qixuan (AUTHOR)
Wen, Xiaoyuan (AUTHOR)
Yang, Ziting (AUTHOR)
Zhang, Yan (AUTHOR)
Qiang, Yan (AUTHOR)
Wu, Kun (AUTHOR)
Fan, Xiaole (AUTHOR)
Ren, Xiaoqiang (AUTHOR)
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Źródło:
BMC Bioinformatics. 4/1/2024, Vol. 25 Issue 1, p1-24. 24p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interpreting drug synergy in breast cancer with deep learning using target-protein inhibition profiles.
Autorzy:
Srithanyarat, Thanyawee (AUTHOR)
Taoma, Kittisak (AUTHOR)
Sutthibutpong, Thana (AUTHOR)
Ruengjitchatchawalya, Marasri (AUTHOR)
Liangruksa, Monrudee (AUTHOR)
Laomettachit, Teeraphan (AUTHOR)
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Źródło:
BioData Mining. 2/29/2024, Vol. 17 Issue 1, p1-17. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity.
Autorzy:
Yu, DongHoon (AUTHOR)
Wagner, Sabrina (AUTHOR)
Schütz, Martin (AUTHOR)
Jeon, Yeejin (AUTHOR)
Seo, Mooyoung (AUTHOR)
Kim, Jaeseung (AUTHOR)
Brückner, Nadine (AUTHOR)
Kicuntod, Jintawee (AUTHOR)
Tillmanns, Julia (AUTHOR)
Wangen, Christina (AUTHOR)
Hahn, Friedrich (AUTHOR)
Kaufer, Benedikt B. (AUTHOR)
Neipel, Frank (AUTHOR)
Eickhoff, Jan (AUTHOR)
Klebl, Bert (AUTHOR)
Nam, Kiyean (AUTHOR)
Marschall, Manfred (AUTHOR)
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Źródło:
Pharmaceutics. Feb2024, Vol. 16 Issue 2, p158. 25p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Novel synergistic interactions between monolaurin, a mono-acyl glycerol and β lactam antibiotics against Staphylococcus aureus: an in vitro study.
Autorzy:
Ghany SSHAE; Department of Microbiology and Immunology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.; Department of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, Minia, 11566, Egypt.
Ibrahem RA; Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt. .
El-Gendy AO; Department of Microbiology and Immunology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.
El-Baky RMA; Department of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, Minia, 11566, Egypt.; Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Mustafa A; Faculty of Engineering, October University for Modern Science and Arts (MSA), Giza, Egypt.
Azmy AF; Department of Microbiology and Immunology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.
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Źródło:
BMC infectious diseases [BMC Infect Dis] 2024 Apr 08; Vol. 24 (1), pp. 379. Date of Electronic Publication: 2024 Apr 08.
Typ publikacji:
Journal Article
MeSH Terms:
Staphylococcal Infections*
Methicillin-Resistant Staphylococcus aureus*
Laurates*
Monoglycerides*
Humans ; Staphylococcus aureus ; beta Lactam Antibiotics ; Glycerol/pharmacology ; Drug Synergism ; Anti-Bacterial Agents/pharmacology ; Monobactams/pharmacology ; Microbial Sensitivity Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High-content analysis identified synergistic drug interactions between INK128, an mTOR inhibitor, and HDAC inhibitors in a non-small cell lung cancer cell line.
Autorzy:
Wang S; School of Chemistry and Molecular Engineering at East China Normal University, Shanghai, 200062, China.
Oliveira-Silveira J; Center of Biotechnology, PPGBCM, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, Rio Grande Do Sul, 91501970, Brazil.
Fang G; NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai, 200062, China.; Arts and Science, New York University at Shanghai, Shanghai, 200122, China.
Kang J; NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai, 200062, China. .; Arts and Science, New York University at Shanghai, Shanghai, 200122, China. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Mar 12; Vol. 24 (1), pp. 335. Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/drug therapy
Antineoplastic Agents*/therapeutic use
Humans ; Histone Deacetylase Inhibitors/pharmacology ; MTOR Inhibitors ; Cell Line, Tumor ; Proteasome Inhibitors/therapeutic use ; Pyrimidines/therapeutic use ; TOR Serine-Threonine Kinases/metabolism ; Drug Combinations ; DNA/therapeutic use ; Drug Synergism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Essential Oil Compounds in Combination with Conventional Antibiotics for Dermatology.
Autorzy:
Simbu S; Department of Pharmacy and Pharmacology, Therapeutic Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
Orchard A; Department of Pharmacy and Pharmacology, Therapeutic Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
Vuuren SV; Department of Pharmacy and Pharmacology, Therapeutic Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Mar 08; Vol. 29 (6). Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Oils, Volatile*/pharmacology
Dermatology*
Anti-Infective Agents*/pharmacology
Anti-Bacterial Agents/pharmacology ; Amoxicillin ; Microbial Sensitivity Tests ; Drug Synergism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Combination Treatment with EGFR Inhibitor and Doxorubicin Synergistically Inhibits Proliferation of MCF-7 Cells and MDA-MB-231 Triple-Negative Breast Cancer Cells In Vitro.
Autorzy:
Abrahams B; Department of Basic Medical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein 9301, South Africa.
Gerber A; Department of Basic Medical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein 9301, South Africa.
Hiss DC; Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, Bellville 7535, South Africa.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 06; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:
Journal Article
MeSH Terms:
Doxorubicin*/pharmacology
ErbB Receptors*/antagonists & inhibitors
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/metabolism
Female ; Humans ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; MCF-7 Cells ; Drug Synergism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers.
Autorzy:
Wild, Markus (AUTHOR)
Karner, Dubravka (AUTHOR)
Eickhoff, Jan (AUTHOR)
Wagner, Sabrina (AUTHOR)
Kicuntod, Jintawee (AUTHOR)
Chang, William (AUTHOR)
Barry, Peter (AUTHOR)
Jonjić, Stipan (AUTHOR)
Lenac Roviš, Tihana (AUTHOR)
Marschall, Manfred (AUTHOR)
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Źródło:
Pharmaceutics. Dec2023, Vol. 15 Issue 12, p2680. 19p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unlocking Therapeutic Synergy: Tailoring Drugs for Comorbidities such as Depression and Diabetes through Identical Molecular Targets in Different Cell Types.
Autorzy:
Coppola, Thierry (AUTHOR)
Daziano, Guillaume (AUTHOR)
Legroux, Ilona (AUTHOR)
Béraud-Dufour, Sophie (AUTHOR)
Blondeau, Nicolas (AUTHOR)
Lebrun, Patricia (AUTHOR)
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Źródło:
Cells (2073-4409). Dec2023, Vol. 12 Issue 23, p2768. 16p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interactions of plumbagin with five common antibiotics against Staphylococcus aureus in vitro.
Autorzy:
Bie S; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.
Mo Q; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.
Shi C; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.
Yuan H; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.
Li C; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.
Wu T; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.
Li W; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.
Yu H; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.
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Źródło:
PloS one [PLoS One] 2024 Jan 26; Vol. 19 (1), pp. e0297493. Date of Electronic Publication: 2024 Jan 26 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Methicillin-Resistant Staphylococcus aureus*
Staphylococcal Infections*
Anti-Infective Agents*/pharmacology
Naphthoquinones*
Humans ; Anti-Bacterial Agents/pharmacology ; Staphylococcus aureus ; Drug Synergism ; Microbial Sensitivity Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Augmented drug combination dataset to improve the performance of machine learning models predicting synergistic anticancer effects.
Autorzy:
Liu M; Division of Electrical and Computer Engineering, Louisiana State University, Baton Rouge, LA, 70803, USA.
Srivastava G; Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA.
Ramanujam J; Division of Electrical and Computer Engineering, Louisiana State University, Baton Rouge, LA, 70803, USA.; Center for Computation and Technology, Louisiana State University, Baton Rouge, LA, 70803, USA.
Brylinski M; Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA. .; Center for Computation and Technology, Louisiana State University, Baton Rouge, LA, 70803, USA. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 18; Vol. 14 (1), pp. 1668. Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Computational Biology*/methods
Machine Learning*
Drug Synergism ; Drug Combinations ; Drug Therapy, Combination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synergistic effect of two antimicrobial peptides, BP203 and MAP-0403 J-2 with conventional antibiotics against colistin-resistant Escherichia coli and Klebsiella pneumoniae clinical isolates.
Autorzy:
Chatupheeraphat C; Center for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Salaya, Nakhon Pathom, Thailand.
Peamchai J; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Luk-In S; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Yainoy S; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Eiamphungporn W; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
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Źródło:
PloS one [PLoS One] 2023 Nov 16; Vol. 18 (11), pp. e0294287. Date of Electronic Publication: 2023 Nov 16 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Bacterial Agents*/pharmacology
Colistin*/pharmacology
Escherichia coli ; Klebsiella pneumoniae ; Ceftazidime/pharmacology ; Meropenem/pharmacology ; Rifampin/pharmacology ; Antimicrobial Peptides ; Drug Synergism ; Chloramphenicol/pharmacology ; Ciprofloxacin/pharmacology ; Microbial Sensitivity Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correction: DCE-MRI-Derived Parameters in Evaluating Abraxane-Induced Early Vascular Response and the Effectiveness of Its Synergistic Interaction with Cisplatin.
Autorzy:
Sun, Xilin (AUTHOR)
Yang, Lili (AUTHOR)
Yan, Xuefeng (AUTHOR)
Sun, Yingying (AUTHOR)
Zhao, Dongliang (AUTHOR)
Ji, Yang (AUTHOR)
Wang, Kai (AUTHOR)
Chen, Xiaoyuan (AUTHOR)
Shen, Baozhong (AUTHOR)
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Źródło:
PLoS ONE. 8/25/2023, Vol. 18 Issue 8, p1-4. 4p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In Vitro antibiotic combinations of Colistin, Meropenem, Amikacin, and Amoxicillin/clavulanate against multidrug-resistant Klebsiella pneumonia isolated from patients with ventilator-associated pneumonia.
Autorzy:
Bayatinejad G; Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Salehi M; Department of Infectious Diseases and Tropical Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.; Research Center for Antibiotic Stewardship and Antimicrobial Resistance, Tehran University of Medical Sciences, Tehran, Iran.
Beigverdi R; Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Halimi S; Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Emaneini M; Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Jabalameli F; Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. .; Research Center for Antibiotic Stewardship and Antimicrobial Resistance, Tehran University of Medical Sciences, Tehran, Iran. .
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Źródło:
BMC microbiology [BMC Microbiol] 2023 Oct 20; Vol. 23 (1), pp. 298. Date of Electronic Publication: 2023 Oct 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pneumonia, Ventilator-Associated*/drug therapy
Klebsiella Infections*/drug therapy
Humans ; Meropenem/pharmacology ; Colistin/pharmacology ; Amikacin/pharmacology ; Klebsiella pneumoniae ; Drug Synergism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Amoxicillin-Potassium Clavulanate Combination/pharmacology ; Microbial Sensitivity Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synergistic antibacterial action of the iron complex and ampicillin against Staphylococcus aureus.
Autorzy:
Kosaristanova L; Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic.
Rihacek M; Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic.
Sucha F; Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic.
Milosavljevic V; Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic.
Svec P; Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic.
Dorazilova J; Central European Institute of Technology, University of Technology, Brno, Czech Republic.
Vojtova L; Central European Institute of Technology, University of Technology, Brno, Czech Republic.
Antal P; Department of Inorganic Chemistry, Faculty of Science, Palacky University, Olomouc, Czech Republic.
Kopel P; Department of Inorganic Chemistry, Faculty of Science, Palacky University, Olomouc, Czech Republic.
Patocka Z; Department of Forest Management and Applied Geoinformatics, Faculty of Forestry and Wood Technology, Mendel University in Brno, Brno, Czech Republic.
Adam V; Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic.
Zurek L; Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic.
Dolezelikova K; Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic. .
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Źródło:
BMC microbiology [BMC Microbiol] 2023 Oct 06; Vol. 23 (1), pp. 288. Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Staphylococcal Infections*/drug therapy
Methicillin-Resistant Staphylococcus aureus*
Humans ; Staphylococcus aureus ; Ampicillin/pharmacology ; Drug Synergism ; Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells.
Autorzy:
Cherkasova V; Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.
Ilnytskyy Y; Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.
Kovalchuk O; Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.
Kovalchuk I; Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 29; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 29.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabidiol*/pharmacology
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Humans ; Cisplatin/pharmacology ; Cell Line, Tumor ; Apoptosis/genetics ; Gene Expression Profiling ; Drug Synergism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Polymyxin B Combined with Minocycline: A Potentially Effective Combination against bla OXA-23 -harboring CRAB in In Vitro PK/PD Model.
Autorzy:
Qu X; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.; Phase I Unit, Huashan Hospital, Fudan University, Shanghai 200040, China.
Bian X; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai 201203, China.
Chen Y; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.; Phase I Unit, Huashan Hospital, Fudan University, Shanghai 200040, China.
Hu J; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Huang X; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Wang Y; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Fan Y; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Wu H; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Li X; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Li Y; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Guo B; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Liu X; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Zhang J; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai 200040, China.; National Health Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.; Phase I Unit, Huashan Hospital, Fudan University, Shanghai 200040, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Feb 06; Vol. 27 (3). Date of Electronic Publication: 2022 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Synergism*
Acinetobacter Infections/*drug therapy
Acinetobacter baumannii/*drug effects
Anti-Bacterial Agents/*pharmacology
Carbapenem-Resistant Enterobacteriaceae/*drug effects
Minocycline/*pharmacology
Polymyxin B/*pharmacology
Acinetobacter Infections/microbiology ; Anti-Bacterial Agents/pharmacokinetics ; Carbapenems/pharmacology ; Drug Therapy, Combination ; In Vitro Techniques ; Minocycline/pharmacokinetics ; Polymyxin B/pharmacokinetics ; Tissue Distribution ; beta-Lactamases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In vitro additive effects of dalbavancin and rifampicin against biofilm of Staphylococcus aureus.
Autorzy:
Jacob B; Orthopaedic Professorship of the University Hospital Jena, Campus Eisenberg, Klosterlausnitzer Straße 81, 07607, Eisenberg, Germany. .
Makarewicz O; Institute for Infectious Diseases and Infection Control, Jena University Hospital, 07747, Jena, Germany.
Hartung A; Institute for Infectious Diseases and Infection Control, Jena University Hospital, 07747, Jena, Germany.
Brodt S; Orthopaedic Professorship of the University Hospital Jena, Campus Eisenberg, Klosterlausnitzer Straße 81, 07607, Eisenberg, Germany.
Roehner E; Orthopaedic Professorship of the University Hospital Jena, Campus Eisenberg, Klosterlausnitzer Straße 81, 07607, Eisenberg, Germany.
Matziolis G; Orthopaedic Professorship of the University Hospital Jena, Campus Eisenberg, Klosterlausnitzer Straße 81, 07607, Eisenberg, Germany.
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Źródło:
Scientific reports [Sci Rep] 2021 Dec 06; Vol. 11 (1), pp. 23425. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Synergism*
Biofilms/*drug effects
Rifampin/*administration & dosage
Staphylococcal Infections/*drug therapy
Staphylococcus aureus/*drug effects
Teicoplanin/*analogs & derivatives
Agar/chemistry ; Anti-Bacterial Agents/pharmacology ; Glycopeptides/pharmacology ; Humans ; In Vitro Techniques ; Microbial Sensitivity Tests ; Microscopy, Fluorescence ; Polyethylene/chemistry ; Staphylococcal Infections/microbiology ; Stem Cells ; Teicoplanin/administration & dosage ; Vancomycin/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Combinations of Calcitriol with Anticancer Treatments for Breast Cancer: An Update.
Autorzy:
Segovia-Mendoza M; Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
García-Quiroz J; Departamento de Biología de la Reproducción Dr. Carlos Gual Castro, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Belisario Domínguez Sección XVI, Tlalpan, Ciudad de México 14080, Mexico.
Díaz L; Departamento de Biología de la Reproducción Dr. Carlos Gual Castro, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Belisario Domínguez Sección XVI, Tlalpan, Ciudad de México 14080, Mexico.
García-Becerra R; Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 25; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Drug Synergism*
Antineoplastic Agents/*therapeutic use
Breast Neoplasms/*drug therapy
Calcitriol/*therapeutic use
Apoptosis ; Bone Density Conservation Agents/therapeutic use ; Breast Neoplasms/pathology ; Drug Therapy, Combination ; Female ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
BTK and PI3K Inhibitors Reveal Synergistic Inhibitory Anti-Tumoral Effects in Canine Diffuse Large B-Cell Lymphoma Cells.
Autorzy:
Kong W; Department of Medicine Clinic III, Hematology, Oncology and Palliative Medicine, Rostock University Medical Center, 18057 Rostock, Germany.; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.; Institute of Muscle Biology and Growth, Research Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany.
Sender S; Department of Medicine Clinic III, Hematology, Oncology and Palliative Medicine, Rostock University Medical Center, 18057 Rostock, Germany.
Taher L; Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, 18057 Rostock, Germany.; Institute of Biomedical Informatics, Graz University of Technology, 8010 Graz, Austria.
Villa-Perez S; Department of Medicine Clinic III, Hematology, Oncology and Palliative Medicine, Rostock University Medical Center, 18057 Rostock, Germany.
Ma Y; Department of Medicine Clinic III, Hematology, Oncology and Palliative Medicine, Rostock University Medical Center, 18057 Rostock, Germany.
Sekora A; Department of Medicine Clinic III, Hematology, Oncology and Palliative Medicine, Rostock University Medical Center, 18057 Rostock, Germany.
Ruetgen BC; Department for Pathobiology, Clinical Pathology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Brenig B; Department of Animal Sciences, Faculty of Agricultural Sciences, University of Goettingen, 37077 Goettingen, Germany.
Beck J; Chronix Biomedical Goettingen, 37079 Goettingen, Germany.
Schuetz E; Department of Animal Sciences, Faculty of Agricultural Sciences, University of Goettingen, 37077 Goettingen, Germany.
Junghanss C; Department of Medicine Clinic III, Hematology, Oncology and Palliative Medicine, Rostock University Medical Center, 18057 Rostock, Germany.
Nolte I; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Murua Escobar H; Department of Medicine Clinic III, Hematology, Oncology and Palliative Medicine, Rostock University Medical Center, 18057 Rostock, Germany.; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 24; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 24.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Synergism*
Adenine/*analogs & derivatives
Agammaglobulinaemia Tyrosine Kinase/*antagonists & inhibitors
Lymphoma, Large B-Cell, Diffuse/*drug therapy
Phosphatidylinositol 3-Kinases/*chemistry
Phosphoinositide-3 Kinase Inhibitors/*pharmacology
Piperidines/*pharmacology
Adenine/pharmacology ; Animals ; Apoptosis ; Cell Proliferation ; Dogs ; Drug Therapy, Combination ; Lymphoma, Large B-Cell, Diffuse/metabolism ; Lymphoma, Large B-Cell, Diffuse/pathology ; Signal Transduction ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-25 z 14236

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