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Tytuł :
Screening inhibitors for blocking UHRF1-methylated DNA interaction with capillary electrophoresis.
Autorzy :
Lou C; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China; School of physical science and technology, ShanghaiTech University, Haike Road 100, Shanghai, 200120, China; University of Chinese Academy of Sciences.
Ye X; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China; School of physical science and technology, ShanghaiTech University, Haike Road 100, Shanghai, 200120, China; University of Chinese Academy of Sciences.
Chen G; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Road, Shanghai 201210, China.
Zhu J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Road, Shanghai 201210, China.
Kang J; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China; School of physical science and technology, ShanghaiTech University, Haike Road 100, Shanghai, 200120, China. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Jan 11; Vol. 1636, pp. 461790. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Screening Assays, Antitumor*
Antineoplastic Agents/*analysis
Antineoplastic Agents/*pharmacology
CCAAT-Enhancer-Binding Proteins/*metabolism
DNA Methylation/*genetics
Electrophoresis, Capillary/*methods
Ubiquitin-Protein Ligases/*metabolism
Animals ; Antineoplastic Agents/chemistry ; DNA Methylation/drug effects ; Flavanones/chemistry ; Flavanones/pharmacology ; Humans ; Kinetics ; Mitoxantrone/chemistry ; Mitoxantrone/pharmacology ; Proanthocyanidins/chemistry ; Proanthocyanidins/pharmacology
Czasopismo naukowe
Tytuł :
Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma.
Autorzy :
Grbovic-Huezo O; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Pitter KL; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Lecomte N; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Saglimbeni J; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Askan G; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Holm M; Translational Cancer Biology Research Program, University of Helsinki, 00014 Helsinki, Finland.
Melchor JP; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Chandwani R; Department of Surgery, Weill Cornell Medicine, New York, NY 10065.
Joshi S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Haglund C; Translational Cancer Biology Research Program, University of Helsinki, 00014 Helsinki, Finland.
Iacobuzio-Donahue CA; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Chiosis G; Department of Surgery, Weill Cornell Medicine, New York, NY 10065.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Tammela T; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065; .
Leach SD; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065; .; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Molecular and Systems Biology, Dartmouth Geisel School of Medicine and Norris Cotton Cancer Center, Lebanon, NH 03766.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 01; Vol. 117 (48), pp. 30670-30678. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*/methods
Drug Screening Assays, Antitumor*/methods
Antineoplastic Agents/*pharmacology
Adenocarcinoma/metabolism ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Animals ; Antineoplastic Agents/therapeutic use ; Benzodioxoles/pharmacology ; Biomarkers, Tumor ; Cell Line, Tumor ; Disease Models, Animal ; Drug Synergism ; Gene Expression ; Humans ; Immunohistochemistry ; MAP Kinase Signaling System/drug effects ; Mice ; Molecular Targeted Therapy ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Protein Kinase Inhibitors/pharmacology ; Purines/pharmacology ; Pyridones/pharmacology ; Pyrimidinones/pharmacology ; Signal Transduction/drug effects ; Survival Rate ; Treatment Outcome ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids.
Autorzy :
Schuster B; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.; Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, 60637, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Junkin M; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.; Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, 60637, USA.
Kashaf SS; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.; Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, 60637, USA.
Romero-Calvo I; Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, 60637, USA.
Kirby K; Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, 60637, USA.
Matthews J; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.; Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, 60637, USA.
Weber CR; Department of Pathology, The University of Chicago Medicine, Chicago, IL, 60637, USA.
Rzhetsky A; Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, 60637, USA.; Committee on Genetics, Genomics and Systems Biology, Departments of Medicine and Human Genetics, The University of Chicago, Chicago, IL, 60637, USA.
White KP; Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, 60637, USA.; Tempus Labs, Chicago, IL, 60654, USA.
Tay S; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA. .; Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, 60637, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 19; Vol. 11 (1), pp. 5271. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antineoplastic Agents/*pharmacology
Drug Screening Assays, Antitumor/*methods
Microfluidics/*methods
Organoids/*drug effects
Automation ; Cell Culture Techniques ; Drug Screening Assays, Antitumor/instrumentation ; Humans ; Microfluidics/instrumentation ; Pancreatic Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
Generation of induced neural stem cells with inducible IDH1R132H for analysis of glioma development and drug testing.
Autorzy :
Rosiak-Stec K; Department of Tumor Biology, Medical University of Lodz, Lodz, Poland.
Grot D; Department of Tumor Biology, Medical University of Lodz, Lodz, Poland.
Rieske P; Department of Tumor Biology, Medical University of Lodz, Lodz, Poland.
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Źródło :
PloS one [PLoS One] 2020 Sep 18; Vol. 15 (9), pp. e0239325. Date of Electronic Publication: 2020 Sep 18 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Screening Assays, Antitumor*
Mutation*
Carcinogenesis/*genetics
Glioma/*pathology
Isocitrate Dehydrogenase/*genetics
Neural Stem Cells/*cytology
Cell Differentiation ; Cell Line ; Humans
Czasopismo naukowe
Tytuł :
Report of the use of patient-derived xenograft models in the development of anticancer drugs in Japan.
Autorzy :
Tsumura R; Division of Developmental Therapeutics, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Koga Y; Department of Strategic Programs, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Hamada A; Division of Molecular Pharmacology and Pharmacokinetics, National Cancer Center Research Institute, Tokyo, Japan.
Kuwata T; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.
Sasaki H; Department of Translational Oncology, Fundamental Innovative Oncology Core Center, National Cancer Center Research Institute, Tokyo, Japan.
Doi T; Department of Experimental Therapeutics, National Cancer Center Hospital East, Kashiwa, Japan.
Aikawa K; Seeds Development Support Section, Translational Research Management Division, National Cancer Center Hospital East, Kashiwa, Japan.
Ohashi A; Division of Translational Genomics, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Katano I; Central Institute for Experimental Animals, Kawasaki, Japan.
Ikarashi Y; Office of New Drug V, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan.
Ito M; Central Institute for Experimental Animals, Kawasaki, Japan.
Ochiai A; Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
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Źródło :
Cancer science [Cancer Sci] 2020 Sep; Vol. 111 (9), pp. 3386-3394. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Screening Assays, Antitumor*/methods
Xenograft Model Antitumor Assays*
Antineoplastic Agents/*pharmacology
Animals ; Disease Models, Animal ; Drug Development ; Humans ; Japan ; Mice ; Species Specificity
Czasopismo naukowe
Tytuł :
Discovering the hidden messages within cell trajectories using a deep learning approach for in vitro evaluation of cancer drug treatments.
Autorzy :
Mencattini A; Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy.
Di Giuseppe D; Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy.
Comes MC; Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy.
Casti P; Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy.
Corsi F; Department of Chemical Science and Technologies, University of Rome Tor Vergata, Rome, Italy.
Bertani FR; Institute for Photonics and Nanotechnology, Italian National Research Council, 00156, Rome, Italy.
Ghibelli L; Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Businaro L; Institute for Photonics and Nanotechnology, Italian National Research Council, 00156, Rome, Italy.
Di Natale C; Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy.
Parrini MC; Institute Curie, Centre de Recherche, Paris Sciences et Lettres Research University, 75005, Paris, France.
Martinelli E; Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy. .
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Źródło :
Scientific reports [Sci Rep] 2020 May 06; Vol. 10 (1), pp. 7653. Date of Electronic Publication: 2020 May 06.
Typ publikacji :
Journal Article
MeSH Terms :
Computational Biology*/methods
Computational Biology*/standards
Drug Screening Assays, Antitumor*/methods
Drug Screening Assays, Antitumor*/standards
Machine Learning*
Antineoplastic Agents/*pharmacology
Algorithms ; Bioengineering ; Cell Tracking ; Humans ; Molecular Imaging/methods ; Reproducibility of Results ; Time-Lapse Imaging
Czasopismo naukowe
Tytuł :
The identification of candidate effective combination regimens for pancreatic cancer using the histoculture drug response assay.
Autorzy :
Jun E; Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, AMIST, University of Ulsan College of Medicine, 388-1 Pungnap-2 Dong, Songpa-gu, Seoul, 05505, South Korea.; Department of Convergence Medicine, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Korea.
Park Y; Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, AMIST, University of Ulsan College of Medicine, 388-1 Pungnap-2 Dong, Songpa-gu, Seoul, 05505, South Korea.
Lee W; Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, AMIST, University of Ulsan College of Medicine, 388-1 Pungnap-2 Dong, Songpa-gu, Seoul, 05505, South Korea.
Kwon J; Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, AMIST, University of Ulsan College of Medicine, 388-1 Pungnap-2 Dong, Songpa-gu, Seoul, 05505, South Korea.
Lee S; Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, 05505, Korea.
Kim MB; MetaBio, Inc., Gangdong-gu, Seoul, 05327, Korea.
Lee JS; MetaBio, Inc., Gangdong-gu, Seoul, 05327, Korea.
Song KB; Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, AMIST, University of Ulsan College of Medicine, 388-1 Pungnap-2 Dong, Songpa-gu, Seoul, 05505, South Korea.
Hwang DW; Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, AMIST, University of Ulsan College of Medicine, 388-1 Pungnap-2 Dong, Songpa-gu, Seoul, 05505, South Korea.
Lee JH; Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, AMIST, University of Ulsan College of Medicine, 388-1 Pungnap-2 Dong, Songpa-gu, Seoul, 05505, South Korea.
Hoffman RM; Department of Surgery, University of California, San Diego 92103-8220, CA, 92111, USA. .; AntiCancer, Inc., 7917 Ostrow Street, San Diego, CA, 92111, USA. .
Kim SC; Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, AMIST, University of Ulsan College of Medicine, 388-1 Pungnap-2 Dong, Songpa-gu, Seoul, 05505, South Korea. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 20; Vol. 10 (1), pp. 12004. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Screening Assays, Antitumor*
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Pancreatic Neoplasms/*drug therapy
Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Pancreatic Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Automated spheroid generation, drug application and efficacy screening using a deep learning classification: a feasibility study.
Autorzy :
Benning L; Department of Plastic and Hand Surgery, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.
Peintner A; Department of Computer Science, University of Innsbruck, Innsbruck, Austria.
Finkenzeller G; Department of Plastic and Hand Surgery, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.
Peintner L; Institute of Molecular Medicine and Cell Research, Albert Ludwigs University of Freiburg, Stefan Meier Strasse 17, 79104, Freiburg, Germany. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 06; Vol. 10 (1), pp. 11071. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deep Learning*
Drug Screening Assays, Antitumor*
Neural Networks, Computer*
Neoplasms/*pathology
Pharmaceutical Preparations/*metabolism
Spheroids, Cellular/*pathology
Cell Survival ; Feasibility Studies ; Humans ; Neoplasms/drug therapy ; Pharmaceutical Preparations/analysis ; Spheroids, Cellular/drug effects ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Update on in-vivo preclinical research models in adrenocortical carcinoma.
Autorzy :
Kar A; Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine Anschutz Medical Campus Aurora.
Wierman ME; Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine Anschutz Medical Campus Aurora.; Research Service, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado, USA.
Kiseljak-Vassiliades K; Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine Anschutz Medical Campus Aurora.; Research Service, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado, USA.
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Źródło :
Current opinion in endocrinology, diabetes, and obesity [Curr Opin Endocrinol Diabetes Obes] 2020 Jun; Vol. 27 (3), pp. 170-176.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Disease Models, Animal*
Adrenal Cortex Neoplasms/*drug therapy
Adrenocortical Carcinoma/*drug therapy
Drug Screening Assays, Antitumor/*trends
Adrenal Cortex Neoplasms/pathology ; Adrenocortical Carcinoma/pathology ; Animals ; Cell Transformation, Neoplastic/pathology ; Drug Screening Assays, Antitumor/methods ; Humans ; Mice ; Mice, Nude ; Tumor Microenvironment/physiology ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy.
Autorzy :
Pérez-Guijarro E; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Yang HH; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Araya RE; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
El Meskini R; Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Michael HT; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Vodnala SK; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.; Lyell Immunopharma, South San Francisco, CA, USA.
Marie KL; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Smith C; Laboratory Animal Science Program, Leidos Biomedical Research Inc, Frederick, MD, USA.
Chin S; Laboratory Animal Science Program, Leidos Biomedical Research Inc, Frederick, MD, USA.
Lam KC; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Thorkelsson A; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Iacovelli AJ; Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Kulaga A; Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Fon A; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Michalowski AM; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Hugo W; Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Lo RS; Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Restifo NP; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.; Lyell Immunopharma, South San Francisco, CA, USA.
Sharan SK; Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Van Dyke T; Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.; Path Forward Solutions, Frederick, MD, USA.
Goldszmid RS; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Weaver Ohler Z; Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Lee MP; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. .
Day CP; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. .
Merlino G; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. .
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Źródło :
Nature medicine [Nat Med] 2020 May; Vol. 26 (5), pp. 781-791. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Screening Assays, Antitumor*/methods
Immunotherapy*/adverse effects
Immunotherapy*/methods
Melanoma/*pathology
Melanoma/*therapy
Animals ; Antineoplastic Agents, Immunological/therapeutic use ; CTLA-4 Antigen/immunology ; Cells, Cultured ; Disease Models, Animal ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Genetic Heterogeneity ; Humans ; Ipilimumab/therapeutic use ; Melanoma/diagnosis ; Melanoma/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Prognosis ; Programmed Cell Death 1 Receptor/immunology ; RNA-Seq ; Treatment Outcome ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Bilateral murine tumor models for characterizing the response to immune checkpoint blockade.
Autorzy :
Zemek RM; School of Biomedical Sciences, University of Western Australia, Crawley, Western Australia, Australia. .; National Centre for Asbestos Related Diseases, Nedlands, Western Australia, Australia. .; Telethon Kids Institute, University of Western Australia, West Perth, Western Australia, Australia. .
Fear VS; School of Biomedical Sciences, University of Western Australia, Crawley, Western Australia, Australia.; National Centre for Asbestos Related Diseases, Nedlands, Western Australia, Australia.; Telethon Kids Institute, University of Western Australia, West Perth, Western Australia, Australia.
Forbes C; School of Biomedical Sciences, University of Western Australia, Crawley, Western Australia, Australia.; National Centre for Asbestos Related Diseases, Nedlands, Western Australia, Australia.; Telethon Kids Institute, University of Western Australia, West Perth, Western Australia, Australia.
de Jong E; Telethon Kids Institute, University of Western Australia, West Perth, Western Australia, Australia.
Casey TH; National Centre for Asbestos Related Diseases, Nedlands, Western Australia, Australia.
Boon L; Bioceros, Utrecht, The Netherlands.
Lassmann T; Telethon Kids Institute, University of Western Australia, West Perth, Western Australia, Australia.
Bosco A; Telethon Kids Institute, University of Western Australia, West Perth, Western Australia, Australia.
Millward MJ; National Centre for Asbestos Related Diseases, Nedlands, Western Australia, Australia.; Medical School, University of Western Australia, Crawley, Western Australia, Australia.; Department of Medical Oncology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Nowak AK; National Centre for Asbestos Related Diseases, Nedlands, Western Australia, Australia.; Medical School, University of Western Australia, Crawley, Western Australia, Australia.; Department of Medical Oncology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Lake RA; School of Biomedical Sciences, University of Western Australia, Crawley, Western Australia, Australia.; National Centre for Asbestos Related Diseases, Nedlands, Western Australia, Australia.
Lesterhuis WJ; School of Biomedical Sciences, University of Western Australia, Crawley, Western Australia, Australia. .; National Centre for Asbestos Related Diseases, Nedlands, Western Australia, Australia. .; Telethon Kids Institute, University of Western Australia, West Perth, Western Australia, Australia. .
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Źródło :
Nature protocols [Nat Protoc] 2020 May; Vol. 15 (5), pp. 1628-1648. Date of Electronic Publication: 2020 Apr 01.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Immunological*
Drug Screening Assays, Antitumor*
Neoplasms, Experimental*
Animals ; Cell Line, Tumor ; Female ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł :
Identification of Core Genes and Potential Drugs for Castration-Resistant Prostate Cancer Based on Bioinformatics Analysis.
Autorzy :
Liang X; School of Management, Jilin University, Changchun, China.
Hu K; Department of Urology, The First Hospital of Jilin University, Changchun, China.
Li D; Department of Urology, The First Hospital of Jilin University, Changchun, China.
Wang Y; Department of Urology, The First Hospital of Jilin University, Changchun, China.
Liu M; Department of Urology, The First Hospital of Jilin University, Changchun, China.
Wang X; Department of Urology, The First Hospital of Jilin University, Changchun, China.
Zhu W; Department of Urology, The First Hospital of Jilin University, Changchun, China.
Wang X; Department of Urology, The First Hospital of Jilin University, Changchun, China.
Yang Z; College of Water Conservancy and Hydropower Engineering, Sichuan Agricultural University, Yaan, China.
Lu J; Department of Urology, The First Hospital of Jilin University, Changchun, China.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2020 May; Vol. 39 (5), pp. 836-847. Date of Electronic Publication: 2020 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Computational Biology*
Drug Screening Assays, Antitumor*
Prostatic Neoplasms, Castration-Resistant/*drug therapy
Prostatic Neoplasms, Castration-Resistant/*genetics
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; DNA Methylation/drug effects ; Humans ; Male ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Protein Interaction Maps/drug effects ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity screens.
Autorzy :
Larsson P; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. .
Engqvist H; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Biermann J; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Werner Rönnerman E; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Forssell-Aronsson E; Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Kovács A; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Karlsson P; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Helou K; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Parris TZ; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
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Źródło :
Scientific reports [Sci Rep] 2020 Apr 02; Vol. 10 (1), pp. 5798. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Inhibitory Concentration 50*
Drug Screening Assays, Antitumor/*standards
Antineoplastic Agents/toxicity ; Bortezomib/toxicity ; Carboplatin/toxicity ; Cell Survival ; Cisplatin/toxicity ; Dimethyl Sulfoxide/standards ; Drug Screening Assays, Antitumor/methods ; Humans ; MCF-7 Cells ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Random vs Targeted Urine Drug Testing Among Patients Undergoing Long-term Opioid Treatment for Cancer Pain.
Autorzy :
Arthur J; Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston.
Lu Z; Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston.
Nguyen K; Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston.
Hui D; Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston.
Prado B; Department of Oncology and Hematology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
Edwards T; Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston.
Bruera E; Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston.
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Źródło :
JAMA oncology [JAMA Oncol] 2020 Apr 01; Vol. 6 (4), pp. 580-581.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Screening Assays, Antitumor*
Analgesics, Opioid/*urine
Cancer Pain/*drug therapy
Neoplasms/*urine
Cancer Pain/pathology ; Cancer Pain/urine ; Chronic Pain/drug therapy ; Chronic Pain/urine ; Female ; Humans ; Male ; Mass Screening ; Middle Aged ; Neoplasms/complications ; Neoplasms/drug therapy ; Pain Management/methods
Czasopismo naukowe
Tytuł :
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations.
Autorzy :
Trzaska C; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-UMR-S 1277, CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000, Lille, France.
Amand S; Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique, Laboratory Molecules of Communication and Adaptation of Microorganisms (MCAM), UMR 7245 CNRS-MNHN, 75005, Paris, France.
Bailly C; Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique, Laboratory Molecules of Communication and Adaptation of Microorganisms (MCAM), UMR 7245 CNRS-MNHN, 75005, Paris, France.
Leroy C; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-UMR-S 1277, CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000, Lille, France.
Marchand V; Next-Generation Sequencing Core Facility, UMS2008 IBSLor CNRS-Université de Lorraine-INSERM, BioPôle, 54505, Vandoeuvre-les-Nancy, France.
Duvernois-Berthet E; Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique, Laboratoire Physiologie Moléculaire et Adaptation (PhyMA), UMR7221 CNRS-MNHN, 75005, Paris, France.
Saliou JM; CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019, UMR 8204, CIIL‑Centre d'Infection et d'Immunité de Lille, University of Lille, 59000, Lille, France.
Benhabiles H; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-UMR-S 1277, CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000, Lille, France.
Werkmeister E; Cellular Microbiology and Physics of Infection Group, Center for Infection and Immunity of Lille, CNRS UMR8204, INSERM U1019, Institut Pasteur de Lille, Lille Regional Univ. Hosp. Centr., Lille Univ., Lille, 59000, France.
Chassat T; Institut Pasteur de Lille - PLEHTA (Plateforme d'expérimentation et de Haute Technologie Animale), 59019, Lille, France.
Guilbert R; Institut Pasteur de Lille - PLEHTA (Plateforme d'expérimentation et de Haute Technologie Animale), 59019, Lille, France.
Hannebique D; Institut Pasteur de Lille - PLEHTA (Plateforme d'expérimentation et de Haute Technologie Animale), 59019, Lille, France.
Mouray A; Institut Pasteur de Lille - PLEHTA (Plateforme d'expérimentation et de Haute Technologie Animale), 59019, Lille, France.
Copin MC; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-UMR-S 1277, CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000, Lille, France.
Moreau PA; Univ. Lille, Fac. Pharmacie Lille, ULR 4515, LGCgE, Laboratoire de Génie Civil et géo-Environnement, 59000, Lille, France.
Adriaenssens E; Univ. Lille, CNRS, INSERM, CHU.Lille, Centre Oscar Lambert, UMR9020-UMR1277, CANTHER - Cancer Heterogeneity, Plasticity and Résistance to Therapies, 59000, Lille, France.
Kulozik A; Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital and Hopp Children's Tumor Center Heidelberg, EMBL/Medical Faculty Molecular Medicine Partnership Unit, 69120, Heidelberg, Germany.
Westhof E; Architecture and Reactivity of RNA, Institute of Molecular and Cellular Biology of the CNRS UPR9002/University of Strasbourg, Strasbourg, 67084, France.
Tulasne D; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-UMR-S 1277, CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000, Lille, France.
Motorin Y; Ingénierie Moléculaire et Physiopathologie Articulaire, UMR7365, CNRS - Université de Lorraine, 54505, Vandoeuvre-les-Nancy, France.
Rebuffat S; Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique, Laboratory Molecules of Communication and Adaptation of Microorganisms (MCAM), UMR 7245 CNRS-MNHN, 75005, Paris, France.
Lejeune F; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-UMR-S 1277, CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000, Lille, France. .
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Źródło :
Nature communications [Nat Commun] 2020 Mar 20; Vol. 11 (1), pp. 1509. Date of Electronic Publication: 2020 Mar 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Drug Screening Assays, Antitumor*
2-Aminopurine/*analogs & derivatives
2-Aminopurine/*pharmacology
Codon, Nonsense/*drug effects
Mutation/*drug effects
Animals ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic/drug effects ; Genes, p53/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Lepisma/chemistry ; Mice ; Mice, Nude ; RNA, Transfer/genetics ; tRNA Methyltransferases/metabolism
Czasopismo naukowe
Tytuł :
A Camera Sensors-Based System to Study Drug Effects On In Vitro Motility: The Case of PC-3 Prostate Cancer Cells.
Autorzy :
Comes MC; Dept. Electronic Engineering, University of Rome Tor Vergata, 00133 Roma, Italy.
Mencattini A; Dept. Electronic Engineering, University of Rome Tor Vergata, 00133 Roma, Italy.
Di Giuseppe D; Dept. Electronic Engineering, University of Rome Tor Vergata, 00133 Roma, Italy.
Filippi J; Dept. Electronic Engineering, University of Rome Tor Vergata, 00133 Roma, Italy.
D'Orazio M; Dept. Electronic Engineering, University of Rome Tor Vergata, 00133 Roma, Italy.
Casti P; Dept. Electronic Engineering, University of Rome Tor Vergata, 00133 Roma, Italy.
Corsi F; Dept. of Chemical Science and Technologies, University of Rome Tor Vergata, 00133 Roma, Italy.
Ghibelli L; Dept. Biology, University of Rome Tor Vergata, 00133 Roma, Italy.
Di Natale C; Dept. Electronic Engineering, University of Rome Tor Vergata, 00133 Roma, Italy.
Martinelli E; Dept. Electronic Engineering, University of Rome Tor Vergata, 00133 Roma, Italy.
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Źródło :
Sensors (Basel, Switzerland) [Sensors (Basel)] 2020 Mar 10; Vol. 20 (5). Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Screening Assays, Antitumor*
Antineoplastic Agents/*pharmacology
Prostate/*drug effects
Prostatic Neoplasms/*drug therapy
Algorithms ; Biomechanical Phenomena ; Cell Movement ; Cluster Analysis ; Humans ; Image Processing, Computer-Assisted/methods ; Machine Learning ; Male ; Microscopy ; Models, Statistical ; Normal Distribution ; PC-3 Cells ; Pattern Recognition, Automated ; Software ; Video Recording
Czasopismo naukowe
Tytuł :
Development of a Colorectal Cancer 3D Micro-tumor Construct Platform From Cell Lines and Patient Tumor Biospecimens for Standard-of-Care and Experimental Drug Screening.
Autorzy :
Forsythe S; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.; Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, 391 Technology Way, Winston-Salem, NC, 27101, USA.
Mehta N; Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, 391 Technology Way, Winston-Salem, NC, 27101, USA.
Devarasetty M; Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, 391 Technology Way, Winston-Salem, NC, 27101, USA.
Sivakumar H; Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, 391 Technology Way, Winston-Salem, NC, 27101, USA.
Gmeiner W; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.; Comprehensive Cancer Center at Wake Forest Baptist Medical, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Soker S; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.; Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, 391 Technology Way, Winston-Salem, NC, 27101, USA.; Comprehensive Cancer Center at Wake Forest Baptist Medical, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.; Virginia Tech-Wake Forest, School of Biomedical Engineering and Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.; Department of Molecular Medicine and Translational Science, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Votanopoulos K; Comprehensive Cancer Center at Wake Forest Baptist Medical, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.; Department of Surgery - Oncology, Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Skardal A; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA. .; Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, 391 Technology Way, Winston-Salem, NC, 27101, USA. .; Comprehensive Cancer Center at Wake Forest Baptist Medical, Medical Center Boulevard, Winston-Salem, NC, 27157, USA. .; Virginia Tech-Wake Forest, School of Biomedical Engineering and Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA. .; Department of Molecular Medicine and Translational Science, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA. .
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Źródło :
Annals of biomedical engineering [Ann Biomed Eng] 2020 Mar; Vol. 48 (3), pp. 940-952. Date of Electronic Publication: 2019 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Screening Assays, Antitumor*
Antineoplastic Agents/*pharmacology
Colorectal Neoplasms/*drug therapy
Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Hydrogels ; Precision Medicine ; Tissue Engineering
Czasopismo naukowe
Tytuł :
Synthesis, characterization and preliminary biological evaluation of chrysin amino acid derivatives that induce apoptosis and EGFR downregulation.
Autorzy :
Liu YM; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), Key Laboratory of the Assembly and Application of Organic Functional molecules of Hunan Province, Hunan Normal University, Changsha 410081, China.; Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.
Li Y; Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.
Liu RF; Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.
Xiao J; Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.
Zhou BN; Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.
Zhang QZ; Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.
Song JX; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), Key Laboratory of the Assembly and Application of Organic Functional molecules of Hunan Province, Hunan Normal University, Changsha 410081, China.
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Źródło :
Journal of Asian natural products research [J Asian Nat Prod Res] 2021 Jan; Vol. 23 (1), pp. 39-54. Date of Electronic Publication: 2019 Dec 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/pharmacology
Amino Acids/pharmacology ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Down-Regulation ; Drug Design ; Drug Screening Assays, Antitumor ; ErbB Receptors/metabolism ; ErbB Receptors/pharmacology ; Flavonoids ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Reactive oxygen species altering the metabolite profile of the marine-derived fungus Dichotomomyces cejpii F31-1.
Autorzy :
Shaker S; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Sun TT; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Wang LY; School of Bioscience & Bioengineering, South China University of Technology, Guangzhou, China.
Ma WZ; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China.
Wu DL; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Guo YW; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Dong J; School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Chen YX; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Zhu LP; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Yang DP; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Li HJ; School of Chemistry, Sun Yat-sen University, Guangzhou, China.
Lan WJ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
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Źródło :
Natural product research [Nat Prod Res] 2021 Jan; Vol. 35 (1), pp. 41-48. Date of Electronic Publication: 2019 Jun 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Aspergillus/*metabolism
Reactive Oxygen Species/*metabolism
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Aspergillus/drug effects ; Culture Media/chemistry ; Diketopiperazines/metabolism ; Drug Screening Assays, Antitumor ; Ergosterol/isolation & purification ; Ergosterol/metabolism ; Ergosterol/pharmacology ; Humans ; Hydrogen Peroxide/pharmacology ; Indoles/chemistry ; Indoles/metabolism ; Indoles/pharmacology ; Male ; Melanoma/drug therapy ; Mice ; Molecular Structure ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Quinazolines/chemistry ; Quinazolines/metabolism ; Quinazolines/pharmacology ; Secondary Metabolism
SCR Organism :
Aspergillus cejpii
Czasopismo naukowe
Tytuł :
Julichrome derivatives and gliotoxin from a soil derived Streptomyces sp.
Autorzy :
Shen T; College of Chemistry and Bioengineering, Lanzhou Jiaotong University, Lanzhou, P. R. China.
Li LM; College of Chemistry and Bioengineering, Lanzhou Jiaotong University, Lanzhou, P. R. China.
Xu ZY; College of Chemistry and Bioengineering, Lanzhou Jiaotong University, Lanzhou, P. R. China.
Wang YD; College of Chemistry and Bioengineering, Lanzhou Jiaotong University, Lanzhou, P. R. China.
Xie WD; Department of Pharmacy, College of Marine Science, Shandong University at Weihai, Weihai, P. R. China.
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Źródło :
Natural product research [Nat Prod Res] 2021 Jan; Vol. 35 (1), pp. 34-40. Date of Electronic Publication: 2019 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Gliotoxin/*pharmacology
Streptomyces/*chemistry
Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; China ; Drug Screening Assays, Antitumor ; Gliotoxin/chemistry ; Gliotoxin/isolation & purification ; Hep G2 Cells ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Soil Microbiology ; Spectrometry, Mass, Electrospray Ionization ; Streptomyces/isolation & purification
Czasopismo naukowe

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