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    Tytuł:
    Scale-up and sustainability of a personalized end-of-life care intervention: a longitudinal mixed-methods study.
    Autorzy:
    Takaoka A; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
    Tam B; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
    Vanstone M; Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.
    Clarke FJ; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
    Hoad N; Department of Critical Care Medicine, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada.
    Swinton M; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
    Toledo F; Department of Spiritual Care, St Joseph's Healthcare, Hamilton, Ontario, Canada.
    Boyle A; Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Palliative Care, St Joseph's Healthcare, Hamilton, Ontario, Canada.
    Woods A; Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Palliative Care, St Joseph's Healthcare, Hamilton, Ontario, Canada.
    Duan EH; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Critical Care Medicine, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada.
    Heels-Ansdell D; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
    Waugh L; Department of Critical Care Medicine, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada.
    Soth M; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Critical Care Medicine, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada.
    Rudkowski J; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Critical Care Medicine, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada.
    Alhazzani W; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Critical Care Medicine, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada.
    Perri D; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Critical Care Medicine, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada.
    Ligori T; Department of Critical Care Medicine, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada.; Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.
    Jaeschke R; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Critical Care Medicine, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada.
    Zytaruk N; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
    Cook DJ; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. .; Department of Medicine, McMaster University, Hamilton, Ontario, Canada. .; Department of Critical Care Medicine, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada. .
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    Źródło:
    BMC health services research [BMC Health Serv Res] 2021 Mar 10; Vol. 21 (1), pp. 218. Date of Electronic Publication: 2021 Mar 10.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Hospice Care*
    Terminal Care*
    Family ; Focus Groups ; Humans ; Intensive Care Units
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study.
    Autorzy:
    Lauzier F; Department of Medicine, Université Laval, Québec, Québec, Canada.; Department of Anesthesiology and Critical Care Medicine, Université Laval, Québec, Québec, Canada.; Centre de recherche du CHU de Québec-Université Laval, Axe Santé des Populations et Pratiques Optimales en Santé, Québec, Québec, Canada.
    Adhikari NK; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
    Seely A; Thoracic Surgery and Critical Care Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
    Koo KKY; Swedish Medical Group, Seattle, Washington, USA.; Department of Medicine, Western University, London, Ontario, Canada.
    Belley-Côté EP; Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.; Department of Medicine, Université de Sherbrooke, Sherbrooke, Québec, Canada.
    Burns KEA; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
    Cook DJ; Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.
    D'Aragon F; Department of Anaesthesiology, Université de Sherbrooke, Québec, Canada.; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Québec, Canada.
    Rochwerg B; Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.
    Kho ME; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
    Oczkowksi SJW; Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.
    Duan EH; Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.
    Meade MO; Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.
    Day AG; Kingston General Hospital Research Institute, Kingston, Ontario, Canada.
    Lamontagne F; Department of Medicine, Université de Sherbrooke, Sherbrooke, Québec, Canada. .; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Québec, Canada. .
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    Corporate Authors:
    for ACCADEMY (Academy of Critical Care – Development, Evaluation, and Methodology)
    Źródło:
    BMC medical research methodology [BMC Med Res Methodol] 2017 Jul 17; Vol. 17 (1), pp. 106. Date of Electronic Publication: 2017 Jul 17.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Clinical Protocols*
    Patient Compliance*
    Randomized Controlled Trials as Topic/*standards
    Research Design/*standards
    Arterial Pressure/drug effects ; Humans ; Hypotension/drug therapy ; Hypotension/etiology ; Pilot Projects ; Randomized Controlled Trials as Topic/methods ; Shock/complications ; Vasoconstrictor Agents/therapeutic use
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: a pilot trial.
    Autorzy:
    Cook DJ; Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON, Canada. .; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada. .
    Johnstone J; Public Health Ontario, Toronto, ON, Canada.; St. Joseph's Health Center, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.
    Marshall JC; Department of Surgery, University of Toronto, Toronto, ON, Canada.; Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
    Lauzier F; Research Center of the CHU de Québec - Population Health and Optimal Health Practices Research Unit, Université Laval, Quebec City, QC, Canada.; Department of Medicine, Université Laval, Quebec City, QC, Canada.; Department of Anesthesiology and Critical Care, Université Laval, Quebec City, QC, Canada.
    Thabane L; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
    Mehta S; Department of Medicine, University of Toronto, Toronto, ON, Canada.; Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
    Dodek PM; Division of Critical Care Medicine, St. Paul's Hospital and University of British Columbia, Vancouver, BC, Canada.; Center for Health Evaluation and Outcome Sciences, St. Paul's Hospital and University of British Columbia, Vancouver, BC, Canada.
    McIntyre L; Division of Critical Care, University of Ottawa, Ottawa, ON, Canada.
    Pagliarello J; Division of Critical Care, University of Ottawa, Ottawa, ON, Canada.
    Henderson W; Division of Critical Care Medicine, Vancouver General Hospital, Vancouver, BC, Canada.
    Taylor RW; Department of Critical Care Medicine, Mercy Hospital, St Louis, MO, USA.
    Cartin-Ceba R; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
    Golan E; Department of Medicine, University of Toronto, Toronto, ON, Canada.; Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
    Herridge M; Department of Medicine, University of Toronto, Toronto, ON, Canada.; Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
    Wood G; Department of Anesthesia & Critical Care, Vancouver Island Health Authority, Victoria, BC, Canada.
    Ovakim D; Department of Anesthesia & Critical Care, Vancouver Island Health Authority, Victoria, BC, Canada.
    Karachi T; Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON, Canada.
    Surette MG; Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON, Canada.
    Bowdish DM; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
    Lamarche D; Biochemistry and Biomedical Sciences Department, McMaster University, Hamilton, ON, Canada.
    Verschoor CP; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
    Duan EH; Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON, Canada.
    Heels-Ansdell D; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
    Arabi Y; King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
    Meade M; Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON, Canada.; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
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    Corporate Authors:
    PROSPECT Investigators and the Canadian Critical Care Trials Group
    Źródło:
    Trials [Trials] 2016 Aug 02; Vol. 17, pp. 377. Date of Electronic Publication: 2016 Aug 02.
    Typ publikacji:
    Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Intubation, Intratracheal/*adverse effects
    Lacticaseibacillus rhamnosus/*growth & development
    Pneumonia, Bacterial/*prevention & control
    Pneumonia, Ventilator-Associated/*prevention & control
    Probiotics/*administration & dosage
    Trachea/*microbiology
    Adult ; Aged ; Canada ; Feasibility Studies ; Female ; Hospital Mortality ; Humans ; Intensive Care Units ; Intubation, Intratracheal/mortality ; Length of Stay ; Male ; Middle Aged ; Pilot Projects ; Pneumonia, Bacterial/diagnosis ; Pneumonia, Bacterial/microbiology ; Pneumonia, Bacterial/mortality ; Pneumonia, Ventilator-Associated/diagnosis ; Pneumonia, Ventilator-Associated/microbiology ; Pneumonia, Ventilator-Associated/mortality ; Probiotics/adverse effects ; Severity of Illness Index ; Time Factors ; Treatment Outcome ; United States
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition.
    Autorzy:
    Jones RB; Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada. />Garrison KE
    Wong JC
    Duan EH
    Nixon DF
    Ostrowski MA
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    Źródło:
    PloS one [PLoS One] 2008 Feb 06; Vol. 3 (2), pp. e1547. Date of Electronic Publication: 2008 Feb 06.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genome, Human*
    Long Interspersed Nucleotide Elements/*drug effects
    Retroelements/*drug effects
    Reverse Transcriptase Inhibitors/*adverse effects
    Drug Evaluation ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Long Interspersed Nucleotide Elements/genetics ; Nucleosides/adverse effects ; Nucleosides/chemistry ; Reverse Transcriptase Inhibitors/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-6 z 6

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