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Wyszukujesz frazę ""E2F Transcription Factors"" wg kryterium: Temat


Tytuł:
RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling.
Autorzy:
Militi S; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LD, UK.
Nibhani R; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LD, UK.
Jalali M; Anne McLaren Laboratory for Regenerative Medicine, Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Pauklin S; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LD, UK. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2023 Sep 26; Vol. 42 (9), pp. 113146. Date of Electronic Publication: 2023 Sep 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Retinoblastoma Protein*/genetics
Retinoblastoma Protein*/metabolism
Signal Transduction*
Body Patterning*
Humans ; Cell Cycle ; Cell Differentiation ; Cell Division ; E2F Transcription Factors/genetics ; E2F Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Regulation of Multiple Fission and Cell-Cycle-Dependent Gene Expression by CDKA1 and the Rb-E2F Pathway in Chlamydomonas.
Autorzy:
Cross FR; The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: .
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Źródło:
Current biology : CB [Curr Biol] 2020 May 18; Vol. 30 (10), pp. 1855-1865.e4. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
CDC2 Protein Kinase/*metabolism
Cell Cycle/*physiology
Chlamydomonas reinhardtii/*metabolism
E2F Transcription Factors/*metabolism
CDC2 Protein Kinase/genetics ; E2F Transcription Factors/genetics ; Gene Expression Regulation ; Mutation ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Retinoblastoma Protein/genetics ; Retinoblastoma Protein/metabolism ; Transcription Factor DP1/genetics ; Transcription Factor DP1/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł:
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression.
Autorzy:
Sanidas I; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Lee H; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Rumde PH; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Boulay G; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
Morris R; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Golczer G; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Stanzione M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Hajizadeh S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Zhong J; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Ryan MB; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Corcoran RB; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Drapkin BJ; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA; UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Rivera MN; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
Dyson NJ; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA. Electronic address: .
Lawrence MS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2022 Sep 15; Vol. 82 (18), pp. 3333-3349.e9. Date of Electronic Publication: 2022 Aug 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Chromatin*/genetics
Retinoblastoma Protein*/genetics
Retinoblastoma Protein*/metabolism
Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; E2F Transcription Factors/genetics ; E2F Transcription Factors/metabolism ; E2F1 Transcription Factor/genetics ; E2F1 Transcription Factor/metabolism ; Promoter Regions, Genetic ; Transcription Factor AP-1/genetics
Czasopismo naukowe
Tytuł:
DREAM represses distinct targets by cooperating with different THAP domain proteins.
Autorzy:
Gal C; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.
Carelli FN; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.
Appert A; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.
Cerrato C; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.
Huang N; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.
Dong Y; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.
Murphy J; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.
Frapporti A; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.
Ahringer J; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2021 Oct 19; Vol. 37 (3), pp. 109835.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*metabolism
Retinoblastoma Protein/*metabolism
Transcription Factors/*metabolism
Animals ; Animals, Genetically Modified ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; DNA Methylation ; E2F Transcription Factors/genetics ; E2F Transcription Factors/metabolism ; Gene Expression Regulation ; Histones/genetics ; Histones/metabolism ; Promoter Regions, Genetic ; Protein Binding ; Protein Interaction Domains and Motifs ; Retinoblastoma Protein/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł:
Controlling Depth of Cellular Quiescence by an Rb-E2F Network Switch.
Autorzy:
Kwon JS; Department of Molecular & Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
Everetts NJ; Department of Molecular & Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
Wang X; Department of Molecular & Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
Wang W; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Della Croce K; Department of Molecular & Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
Xing J; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Yao G; Department of Molecular & Cellular Biology, University of Arizona, Tucson, AZ 85721, USA; Arizona Cancer Center, University of Arizona, Tucson, AZ 85719, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2017 Sep 26; Vol. 20 (13), pp. 3223-3235.
Typ publikacji:
Journal Article
MeSH Terms:
Models, Biological*
Cellular Senescence/*genetics
E2F Transcription Factors/*genetics
Retinoblastoma Protein/*genetics
Animals ; Cell Division ; Cell Proliferation/genetics ; E2F Transcription Factors/metabolism ; Fibroblasts ; Gene Regulatory Networks ; Humans ; Rats ; Retinoblastoma Protein/metabolism
Czasopismo naukowe
Tytuł:
The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells.
Autorzy:
Gubern A; Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
Joaquin M; Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
Marquès M; Epithelial Carcinogenesis Group, Cancer Cell Biology Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain; Departament de Ciències Experimentals i de la Salut, UPF, 08003 Barcelona, Spain.
Maseres P; Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
Garcia-Garcia J; Structural Bioinformatics Group (GRIB), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
Amat R; Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
González-Nuñez D; Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
Oliva B; Structural Bioinformatics Group (GRIB), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
Real FX; Epithelial Carcinogenesis Group, Cancer Cell Biology Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain; Departament de Ciències Experimentals i de la Salut, UPF, 08003 Barcelona, Spain.
de Nadal E; Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain. Electronic address: .
Posas F; Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2016 Oct 06; Vol. 64 (1), pp. 25-36. Date of Electronic Publication: 2016 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Breast Neoplasms/*genetics
Cyclin-Dependent Kinases/*genetics
E2F Transcription Factors/*genetics
Retinoblastoma Protein/*genetics
p38 Mitogen-Activated Protein Kinases/*genetics
Animals ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Cyclin-Dependent Kinases/metabolism ; E2F Transcription Factors/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; Humans ; MAP Kinase Kinase 4/genetics ; MAP Kinase Kinase 4/metabolism ; Mice ; Molecular Mimicry ; Phosphorylation ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Retinoblastoma Protein/chemistry ; Retinoblastoma Protein/metabolism ; Signal Transduction ; Xenograft Model Antitumor Assays ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł:
Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage.
Autorzy:
Segeren HA; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
van Rijnberk LM; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Moreno E; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Riemers FM; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
van Liere EA; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Yuan R; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Wubbolts R; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
de Bruin A; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Westendorp B; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2020 Dec 01; Vol. 33 (9), pp. 108449.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Damage/*genetics
E2F Transcription Factors/*metabolism
Sequence Analysis, RNA/*methods
Cell Cycle ; Humans
Czasopismo naukowe
Tytuł:
A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity.
Autorzy:
Wang S; Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China; Department of Biology, Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, P.O. Box 90338, Duke University, Durham, NC 27708, USA. Electronic address: .
Gu Y; Department of Biology, Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, P.O. Box 90338, Duke University, Durham, NC 27708, USA.
Zebell SG; Department of Biology, Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, P.O. Box 90338, Duke University, Durham, NC 27708, USA.
Anderson LK; Department of Biology, Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, P.O. Box 90338, Duke University, Durham, NC 27708, USA.
Wang W; Department of Biology, Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, P.O. Box 90338, Duke University, Durham, NC 27708, USA.
Mohan R; Department of Biology, Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, P.O. Box 90338, Duke University, Durham, NC 27708, USA.
Dong X; Department of Biology, Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, P.O. Box 90338, Duke University, Durham, NC 27708, USA. Electronic address: .
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Źródło:
Cell host & microbe [Cell Host Microbe] 2014 Dec 10; Vol. 16 (6), pp. 787-94. Date of Electronic Publication: 2014 Nov 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Arabidopsis/*immunology
Arabidopsis Proteins/*immunology
Cell Cycle Proteins/*immunology
E2F Transcription Factors/*immunology
Plant Diseases/*immunology
Arabidopsis/genetics ; Arabidopsis/microbiology ; Arabidopsis Proteins/genetics ; Cell Cycle Proteins/genetics ; E2F Transcription Factors/genetics ; Membrane Proteins/genetics ; Membrane Proteins/immunology ; Plant Diseases/genetics ; Plant Diseases/microbiology ; Protein Kinases/genetics ; Protein Kinases/immunology ; Pseudomonas syringae/physiology ; Signal Transduction
Czasopismo naukowe
Tytuł:
Direct Comparison of Mononucleated and Binucleated Cardiomyocytes Reveals Molecular Mechanisms Underlying Distinct Proliferative Competencies.
Autorzy:
Windmueller R; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Leach JP; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Babu A; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zhou S; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Morley MP; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wakabayashi A; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Petrenko NB; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Viatour P; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Morrisey EE; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2020 Mar 03; Vol. 30 (9), pp. 3105-3116.e4.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cell Nucleus/*metabolism
Myocytes, Cardiac/*cytology
Myocytes, Cardiac/*metabolism
Animals ; Animals, Newborn ; Base Sequence ; Cell Nucleus/ultrastructure ; Cell Proliferation ; Cell Separation ; Down-Regulation/genetics ; E2F Transcription Factors/metabolism ; Flow Cytometry ; G1 Phase ; Mice, Knockout ; Myocytes, Cardiac/ultrastructure ; Proto-Oncogene Proteins/metabolism ; Regeneration ; Retinoblastoma Protein/metabolism ; S Phase
Czasopismo naukowe
Tytuł:
E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration.
Autorzy:
Sladky VC; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Knapp K; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Soratroi C; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Heppke J; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Eichin F; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Rocamora-Reverte L; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Szabo TG; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Bongiovanni L; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the Netherlands.
Westendorp B; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the Netherlands.
Moreno E; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the Netherlands.
van Liere EA; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the Netherlands.
Bakker B; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands.
Spierings DCJ; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands.
Wardenaar R; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands.
Pereyra D; Department of Surgery, Medical University of Vienna, General Hospital, 1090 Vienna, Austria.
Starlinger P; Department of Surgery, Medical University of Vienna, General Hospital, 1090 Vienna, Austria.
Schultze S; Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, 1090 Vienna, Austria.
Trauner M; Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, 1090 Vienna, Austria.
Stojakovic T; Medical University of Graz, Clinical Institute of Medical and Chemical Laboratory Diagnostics, 8010 Graz, Austria.
Scharnagl H; Medical University of Graz, Clinical Institute of Medical and Chemical Laboratory Diagnostics, 8010 Graz, Austria.
Fava LL; Armenise-Harvard Laboratory of Cell Division, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, 38123 Povo, Italy.
Foijer F; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands.
de Bruin A; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the Netherlands; Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, the Netherlands.
Villunger A; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090 Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. Electronic address: .
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Źródło:
Developmental cell [Dev Cell] 2020 Feb 10; Vol. 52 (3), pp. 335-349.e7. Date of Electronic Publication: 2020 Jan 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Liver Regeneration*
Polyploidy*
Caspase 2/*physiology
Death Domain Receptor Signaling Adaptor Proteins/*physiology
E2F Transcription Factors/*physiology
Hepatocytes/*cytology
Tumor Suppressor Protein p53/*physiology
Aneuploidy ; Animals ; CRADD Signaling Adaptor Protein/physiology ; Centrosome ; Cyclin-Dependent Kinase Inhibitor p21/physiology ; Cytokinesis ; Female ; Hepatocytes/metabolism ; Humans ; Male ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł:
RETRACTED: Comprehensive Analysis of the Expression and Prognosis for E2Fs in Human Breast Cancer
Autorzy:
Sun CC; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: .
Li SJ; Wuhan Hospital for the Prevention and Treatment of Occupational Diseases, Wuhan 430022, Hubei, China.
Hu W; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Zhang J; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Zhou Q; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Liu C; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Li LL; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Songyang YY; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Zhang F; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Chen ZL; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Li G; Department of Oncology, Wuhan Pu-Ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430034, Hubei, China.
Bi ZY; Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Academy for Preventive Medicine, Wuhan 430079, Hubei, China.
Bi YY; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Gong FY; Department of Infectious Diseases, Wuhan Medical Treatment Center, Wuhan 430071, Hubei, China.
Bo T; Department of Infectious Diseases, Wuhan Medical Treatment Center, Wuhan 430071, Hubei, China.
Yuan ZP; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Hu WD; Department of Oncology, ZhongNan Hospital of Wuhan University, Wuhan 430071, Hubei, China.
Zhan BT; Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, Hubei, China.
Zhang Q; Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei, China.
He QQ; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China. Electronic address: .
Li DJ; Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China. Electronic address: .
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Źródło:
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2019 Jun 05; Vol. 27 (6), pp. 1153-1165. Date of Electronic Publication: 2019 Apr 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
MeSH Terms:
Gene Expression Profiling*
Breast Neoplasms/*genetics
Computational Biology/*methods
E2F Transcription Factors/*genetics
Biomarkers, Tumor/genetics ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Disease Progression ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Neoplasm Recurrence, Local/genetics ; Neoplasm Staging ; Precision Medicine ; Prognosis ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł:
A Code of Mono-phosphorylation Modulates the Function of RB.
Autorzy:
Sanidas I; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Morris R; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Fella KA; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Rumde PH; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Boukhali M; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Tai EC; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Ting DT; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Lawrence MS; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
Haas W; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.
Dyson NJ; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2019 Mar 07; Vol. 73 (5), pp. 985-1000.e6. Date of Electronic Publication: 2019 Jan 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Signal Transduction*/genetics
Breast Neoplasms/*metabolism
Retinoblastoma Protein/*metabolism
Breast Neoplasms/genetics ; Cell Line, Tumor ; E2F Transcription Factors/genetics ; E2F Transcription Factors/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Mutation ; Oxidative Phosphorylation ; Phosphorylation ; Protein Binding ; Proteomics/methods ; Retinoblastoma Protein/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł:
Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan.
Autorzy:
Xie J; Nutrition & Metabolism, South Australian Health & Medical Research Institute, Adelaide, SA, Australia; Centre for Biological Sciences, University of Southampton, Southampton, UK.
de Souza Alves V; Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
von der Haar T; School of Biosciences, University of Kent, Canterbury, UK.
O'Keefe L; School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia; Hopwood Centre for Neurobiology, South Australian Health & Medical Research Institute, Adelaide, SA, Australia.
Lenchine RV; Nutrition & Metabolism, South Australian Health & Medical Research Institute, Adelaide, SA, Australia; School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.
Jensen KB; Nutrition & Metabolism, South Australian Health & Medical Research Institute, Adelaide, SA, Australia; School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.
Liu R; Nutrition & Metabolism, South Australian Health & Medical Research Institute, Adelaide, SA, Australia; Centre for Biological Sciences, University of Southampton, Southampton, UK.
Coldwell MJ; Centre for Biological Sciences, University of Southampton, Southampton, UK.
Wang X; Nutrition & Metabolism, South Australian Health & Medical Research Institute, Adelaide, SA, Australia; Centre for Biological Sciences, University of Southampton, Southampton, UK.
Proud CG; Nutrition & Metabolism, South Australian Health & Medical Research Institute, Adelaide, SA, Australia; Centre for Biological Sciences, University of Southampton, Southampton, UK; School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia; Hopwood Centre for Neurobiology, South Australian Health & Medical Research Institute, Adelaide, SA, Australia. Electronic address: .
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Źródło:
Current biology : CB [Curr Biol] 2019 Mar 04; Vol. 29 (5), pp. 737-749.e5. Date of Electronic Publication: 2019 Feb 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Caenorhabditis elegans/*physiology
Elongation Factor 2 Kinase/*genetics
Longevity/*genetics
Protein Biosynthesis/*genetics
Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins ; E2F Transcription Factors ; Elongation Factor 2 Kinase/metabolism
Czasopismo naukowe
Tytuł:
Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation.
Autorzy:
Shamma A; Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Takegami Y
Miki T
Kitajima S
Noda M
Obara T
Okamoto T
Takahashi C
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Źródło:
Cancer cell [Cancer Cell] 2009 Apr 07; Vol. 15 (4), pp. 255-69.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*
DNA Damage*
Protein Prenylation*
E2F Transcription Factors/*metabolism
Genes, ras/*physiology
Retinoblastoma Protein/*physiology
Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adenoma/genetics ; Adenoma/metabolism ; Adenoma/pathology ; Animals ; Brain Stem Neoplasms/genetics ; Brain Stem Neoplasms/metabolism ; Brain Stem Neoplasms/pathology ; Cell Membrane ; Chromatin Immunoprecipitation ; Cyclin-Dependent Kinase Inhibitor p16/physiology ; DNA Repair ; E2F Transcription Factors/genetics ; Humans ; Immunoenzyme Techniques ; Mice ; Mice, Knockout ; Prenylation ; Protein Transport ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/metabolism ; Thyroid Neoplasms/pathology
Czasopismo naukowe
Tytuł:
Proapoptotic function of the retinoblastoma tumor suppressor protein.
Autorzy:
Ianari A; David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
Natale T
Calo E
Ferretti E
Alesse E
Screpanti I
Haigis K
Gulino A
Lees JA
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Źródło:
Cancer cell [Cancer Cell] 2009 Mar 03; Vol. 15 (3), pp. 184-94.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
Apoptosis/*physiology
E2F Transcription Factors/*metabolism
Retinoblastoma Protein/*metabolism
Animals ; Blotting, Western ; Cell Line, Tumor ; DNA Damage/physiology ; E2F Transcription Factors/genetics ; Flow Cytometry ; Humans ; Immunoprecipitation ; Mice ; Mice, Knockout ; Promoter Regions, Genetic ; Retinoblastoma Protein/genetics ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł:
E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.
Autorzy:
Tyagi S; Center for Integrative Genomics, University of Lausanne, Génopode, 1015 Lausanne, Switzerland.
Chabes AL
Wysocka J
Herr W
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Źródło:
Molecular cell [Mol Cell] 2007 Jul 06; Vol. 27 (1), pp. 107-19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
E2F Transcription Factors/*metabolism
Histone-Lysine N-Methyltransferase/*metabolism
Host Cell Factor C1/*metabolism
Lysine/*metabolism
Myeloid-Lymphoid Leukemia Protein/*metabolism
Promoter Regions, Genetic/*genetics
S Phase/*genetics
Amino Acid Sequence ; Conserved Sequence ; E2F Transcription Factors/chemistry ; Evolution, Molecular ; G1 Phase ; HeLa Cells ; Histone Deacetylases/metabolism ; Humans ; Molecular Sequence Data ; Protein Binding ; Protein Structure, Tertiary ; Repressor Proteins/metabolism ; Retinoblastoma Protein/metabolism ; Retinoblastoma-Like Protein p130/metabolism ; Sin3 Histone Deacetylase and Corepressor Complex ; Two-Hybrid System Techniques
Czasopismo naukowe
Tytuł:
Re-evaluating cell-cycle regulation by E2Fs.
Autorzy:
Rowland BD; Division of Molecular Carcinogenesis and Center of Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Bernards R
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Źródło:
Cell [Cell] 2006 Dec 01; Vol. 127 (5), pp. 871-4.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Cycle*
E2F Transcription Factors/*metabolism
Animals ; E2F Transcription Factors/chemistry ; Models, Genetic ; Protein Structure, Tertiary ; Repressor Proteins/metabolism ; Transcriptional Activation
Czasopismo naukowe
Tytuł:
E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression.
Autorzy:
Guarner A; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA.
Morris R; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA.
Korenjak M; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA.
Boukhali M; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA.
Zappia MP; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA.
Van Rechem C; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA.
Whetstine JR; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA.
Ramaswamy S; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA.
Zou L; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA.
Frolov MV; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA.
Haas W; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA.
Dyson NJ; Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA. Electronic address: .
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Źródło:
Developmental cell [Dev Cell] 2017 Dec 18; Vol. 43 (6), pp. 689-703.e5. Date of Electronic Publication: 2017 Dec 07.
Typ publikacji:
Journal Article
MeSH Terms:
Ataxia Telangiectasia Mutated Proteins/*biosynthesis
Drosophila Proteins/*metabolism
E2F Transcription Factors/*genetics
E2F Transcription Factors/*metabolism
Fat Body/*physiology
Trans-Activators/*metabolism
Animals ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Cycle/genetics ; Cell Cycle Proteins/metabolism ; Cell Division/physiology ; DNA Replication ; DNA-Binding Proteins/metabolism ; Drosophila ; Drosophila Proteins/biosynthesis ; Drosophila Proteins/genetics ; Fat Body/cytology ; Protein Serine-Threonine Kinases ; Trans-Activators/genetics ; Transcriptome
Czasopismo naukowe
Tytuł:
Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage.
Autorzy:
Bertoli C; MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK.
Herlihy AE; MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK.
Pennycook BR; MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK.
Kriston-Vizi J; MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK; Bioinformatics Image Core (BIONIC), University College London, London WC1E 6BT, UK.
de Bruin RAM; MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK; The UCL Cancer Institute, University College London, London WC1E 6BT, UK. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2016 May 17; Vol. 15 (7), pp. 1412-1422. Date of Electronic Publication: 2016 May 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transcription, Genetic*
DNA Damage/*genetics
DNA Replication/*genetics
E2F Transcription Factors/*metabolism
Cell Cycle Checkpoints/genetics ; Cell Line ; Humans ; Oncogenes ; Protein Biosynthesis/genetics
Czasopismo naukowe

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