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Wyszukujesz frazę ""EMBO molecular medicine [EMBO Mol Med] NLMUID: 101487380"" wg kryterium: JN


Tytuł:
Basal-epithelial subpopulations underlie and predict chemotherapy resistance in triple-negative breast cancer.
Autorzy:
Inayatullah M; Institute for Molecular Medicine, University of Southern Denmark, Odense M, Denmark.
Mahesh A; Institute for Molecular Medicine, University of Southern Denmark, Odense M, Denmark.
Turnbull AK; Edinburgh Breast Cancer Now Research Group, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Dixon JM; Edinburgh Breast Cancer Now Research Group, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Natrajan R; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
Tiwari VK; Institute for Molecular Medicine, University of Southern Denmark, Odense M, Denmark. .; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University Belfast, Belfast, BT9 7BL, UK. .; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT9 7AE, UK. .; Danish Institute for Advanced Study (DIAS), Odense M, Denmark. .; Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 13. Date of Electronic Publication: 2024 Mar 13.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Reply to Johansson 'Treatment with BRICHOS domain helps to clarify issues with Alzheimer mouse models'.
Autorzy:
D'Adamio L; Department of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Jacqueline Krieger Klein Center in Alzheimer's Disease and Neurodegeneration Research, Rutgers, The State University of New Jersey, 205 South Orange Ave, Newark, NJ, 07103, USA. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 13. Date of Electronic Publication: 2024 Mar 13.
Typ publikacji:
Letter
Opinia redakcyjna
Tytuł:
Treatment with BRICHOS domain helps to clarify issues with Alzheimer mouse models.
Autorzy:
Johansson J; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 13. Date of Electronic Publication: 2024 Mar 13.
Typ publikacji:
Letter; Comment
Opinia redakcyjna
Tytuł:
Organotypic culture of human brain explants as a preclinical model for AI-driven antiviral studies.
Autorzy:
Partiot E; CNRS, Institut de Recherche en Infectiologie de Montpellier (IRIM), 34293, Montpellier, France.; Univ Montpellier, 34090, Montpellier, France.
Gorda B; CNRS, Institut de Recherche en Infectiologie de Montpellier (IRIM), 34293, Montpellier, France.; Univ Montpellier, 34090, Montpellier, France.
Lutz W; CNRS, Institut de Recherche en Infectiologie de Montpellier (IRIM), 34293, Montpellier, France.; Univ Montpellier, 34090, Montpellier, France.
Lebrun S; CNRS, Institut de Recherche en Infectiologie de Montpellier (IRIM), 34293, Montpellier, France.; Univ Montpellier, 34090, Montpellier, France.
Khalfi P; Univ Montpellier, 34090, Montpellier, France.; CNRS, Institut de Génétique Moléculaire de Montpellier (IGMM), 34293, Montpellier, France.
Mora S; Univ Montpellier, 34090, Montpellier, France.; CNRS, Institut de Génétique Moléculaire de Montpellier (IGMM), 34293, Montpellier, France.
Charlot B; Univ Montpellier, 34090, Montpellier, France.; Institut d'Electronique et des Systèmes IES, CNRS, 860 Rue de St - Priest Bâtiment 5, 34090, Montpellier, France.
Majzoub K; Univ Montpellier, 34090, Montpellier, France.; CNRS, Institut de Génétique Moléculaire de Montpellier (IGMM), 34293, Montpellier, France.
Desagher S; CNRS, Institut de Recherche en Infectiologie de Montpellier (IRIM), 34293, Montpellier, France.; Univ Montpellier, 34090, Montpellier, France.; CNRS, Institut de Génétique Moléculaire de Montpellier (IGMM), 34293, Montpellier, France.
Ganesh G; Univ Montpellier, 34090, Montpellier, France.; UM-CNRS Laboratoire d'Informatique de Robotique et de Microelectronique de Montpellier (LIRMM), 161, Rue Ada, 34090, Montpellier, France.
Colomb S; Univ Montpellier, 34090, Montpellier, France.; Equipe de droit pénal et sciences forensiques de Montpellier (EDPFM), Univ. Montpellier, Département de médecine légale, Pôle Urgences, Centre Hospitalo-Universitaire de Montpellier, 371 Avenue du Doyen Gaston Giraud, 34285, Montpellier, France.
Gaudin R; CNRS, Institut de Recherche en Infectiologie de Montpellier (IRIM), 34293, Montpellier, France. .; Univ Montpellier, 34090, Montpellier, France. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 12. Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
The 'communicatome' of pregnancy: spotlight on cellular and extravesicular chimerism.
Autorzy:
Graf I; Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Urbschat C; Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Arck PC; Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. .; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 11. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Tytuł:
Lipidomics reveals new lipid-based lung adenocarcinoma early diagnosis model.
Autorzy:
Sun T; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, 100083, Beijing, China.
Chen J; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, 100083, Beijing, China.
Yang F; Department of Thoracic Surgery, Peking University People's Hospital, 100044, Beijing, China.; Thoracic Oncology Institute, Peking University People's Hospital, 100044, Beijing, China.
Zhang G; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, 100190, Beijing, China.
Chen J; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, 100083, Beijing, China.
Wang X; Department of Thoracic Surgery, Peking University People's Hospital, 100044, Beijing, China. .; Thoracic Oncology Institute, Peking University People's Hospital, 100044, Beijing, China. .
Zhang J; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, 100083, Beijing, China. .; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, 100083, Beijing, China. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 11. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits.
Autorzy:
Xie J; Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.; Brain Research Center, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, 510120, China.; Nanhai Translational Innovation Center of Precision Immunology, Sun Yat-sen Memorial Hospital, Foshan, 528200, China.
Cheng J; Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.; Brain Research Center, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, 510120, China.; Nanhai Translational Innovation Center of Precision Immunology, Sun Yat-sen Memorial Hospital, Foshan, 528200, China.
Ko H; Division of Neurology, Department of Medicine and Therapeutics & Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Tang Y; Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China. .; Brain Research Center, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, 510120, China. .; Nanhai Translational Innovation Center of Precision Immunology, Sun Yat-sen Memorial Hospital, Foshan, 528200, China. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 11. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Tytuł:
Antiviral drugs prolong survival in murine recessive dystrophic epidermolysis bullosa.
Autorzy:
Tartaglia G; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Fuentes I; DEBRA Chile, Santiago, Chile.; Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.; Centro de Genética y Genómica, Facultad de Medicina Clínica Alemana, Universidad de Desarrollo, Santiago, Chile.
Patel N; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA.
Varughese A; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Israel LE; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Park PH; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Alexander MH; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Poojan S; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Cao Q; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Solomon B; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Padron ZM; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Dyer JA; Department of Dermatology, University of Missouri School of Medicine, Columbia, MO, USA.
Mellerio JE; St. John's Institute of Dermatology, King's College London (Guy's Campus), London, UK.
McGrath JA; St. John's Institute of Dermatology, King's College London (Guy's Campus), London, UK.
Palisson F; DEBRA Chile, Santiago, Chile.; Servicio de Dermatologia, Facultad de Medicina Clínica Alemana-Universidad de Desarrollo, Santiago, Chile.
Salas-Alanis J; Instituto Dermtaologico de Jalisco, Guadalajara, Mexico.
Han L; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA.
South AP; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA. .; The Joan and Joel Rosenbloom Research Center for Fibrotic Diseases, Thomas Jefferson University, Philadelphia, PA, USA. .; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. .; Department of Otolaryngology Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 10. Date of Electronic Publication: 2024 Mar 10.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
The regulatory relationship between NAMPT and PD-L1 in cancer and identification of a dual-targeting inhibitor.
Autorzy:
Yang Y; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, PR China.
Li Z; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, PR China.
Wang Y; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, PR China.
Gao J; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, PR China.
Meng Y; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, PR China.
Wang S; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, PR China.
Zhao X; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, PR China.
Tang C; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, PR China.
Yang W; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, PR China.
Li Y; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, PR China.
Bao J; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, 00290, Finland.
Fan X; Department of Pharmacy, Shengjing Hospital of China Medical University, 110004, Shenyang, PR China.
Tang J; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, 00290, Finland.
Yang J; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, PR China.
Wu C; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, PR China.
Qin M; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, PR China. .
Wang L; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China. .; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, PR China. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 06. Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Generalizable anchor aptamer strategy for loading nucleic acid therapeutics on exosomes.
Autorzy:
Han G; State Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & International Joint Laboratory of Ocular Diseases (Ministry of Education), School of Medical Technology & School of Basic Medical Sciences, Tianjin Medical University, Qixiangtai Road, Heping District, 300070, Tianjin, China.
Zhang Y; State Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & International Joint Laboratory of Ocular Diseases (Ministry of Education), School of Medical Technology & School of Basic Medical Sciences, Tianjin Medical University, Qixiangtai Road, Heping District, 300070, Tianjin, China.
Zhong L; State Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & International Joint Laboratory of Ocular Diseases (Ministry of Education), School of Medical Technology & School of Basic Medical Sciences, Tianjin Medical University, Qixiangtai Road, Heping District, 300070, Tianjin, China.
Wang B; State Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & International Joint Laboratory of Ocular Diseases (Ministry of Education), School of Medical Technology & School of Basic Medical Sciences, Tianjin Medical University, Qixiangtai Road, Heping District, 300070, Tianjin, China.
Qiu S; State Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & International Joint Laboratory of Ocular Diseases (Ministry of Education), School of Medical Technology & School of Basic Medical Sciences, Tianjin Medical University, Qixiangtai Road, Heping District, 300070, Tianjin, China.
Song J; State Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & International Joint Laboratory of Ocular Diseases (Ministry of Education), School of Medical Technology & School of Basic Medical Sciences, Tianjin Medical University, Qixiangtai Road, Heping District, 300070, Tianjin, China.
Lin C; State Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & International Joint Laboratory of Ocular Diseases (Ministry of Education), School of Medical Technology & School of Basic Medical Sciences, Tianjin Medical University, Qixiangtai Road, Heping District, 300070, Tianjin, China.
Zou F; Public Laboratory & Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center & Tianjin's Clinical Research Center for Cancer, 300060, Tianjin, China.
Wu J; State Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & International Joint Laboratory of Ocular Diseases (Ministry of Education), School of Medical Technology & School of Basic Medical Sciences, Tianjin Medical University, Qixiangtai Road, Heping District, 300070, Tianjin, China.
Yu H; State Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & International Joint Laboratory of Ocular Diseases (Ministry of Education), School of Medical Technology & School of Basic Medical Sciences, Tianjin Medical University, Qixiangtai Road, Heping District, 300070, Tianjin, China.
Liang C; Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, 518055, Shenzhen, China.
Wen K; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, School of Basic Medical Sciences, Tianjin Medical University, 300070, Tianjin, China.
Seow Y; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis St, Genome, Singapore, 138672, Republic of Singapore.
Yin H; State Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & International Joint Laboratory of Ocular Diseases (Ministry of Education), School of Medical Technology & School of Basic Medical Sciences, Tianjin Medical University, Qixiangtai Road, Heping District, 300070, Tianjin, China. .; Department of Clinical Laboratory, Tianjin Medical University General Hospital, 300052, Tianjin, China. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 06. Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Immunocytokines with activity-on-demand by combination with small molecule inhibitors.
Autorzy:
Müller D; Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 06. Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
A novel strategy to generate immunocytokines with activity-on-demand using small molecule inhibitors.
Autorzy:
Rotta G; Philochem AG, CH-8112, Otelfingen, Switzerland.; Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.
Gilardoni E; Philochem AG, CH-8112, Otelfingen, Switzerland.
Ravazza D; Philochem AG, CH-8112, Otelfingen, Switzerland.
Mock J; Philochem AG, CH-8112, Otelfingen, Switzerland.
Seehusen F; Laboratory for Animal Model Pathology (LAMP), Institute of Veterinary Pathology, University of Zurich, CH-8057, Zurich, Switzerland.
Elsayed A; Philochem AG, CH-8112, Otelfingen, Switzerland.; Institute of Pharmaceutical Sciences, ETH Zurich, CH-8093, Zurich, Switzerland.
Puca E; Philochem AG, CH-8112, Otelfingen, Switzerland.; Philogen S.p.A, 53100, Siena, Italy.
De Luca R; Philochem AG, CH-8112, Otelfingen, Switzerland.
Pellegrino C; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, CH-8091, Zurich, Switzerland.
Look T; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, CH-8091, Zurich, Switzerland.
Weiss T; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, CH-8091, Zurich, Switzerland.
Manz MG; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, CH-8091, Zurich, Switzerland.
Halin C; Institute of Pharmaceutical Sciences, ETH Zurich, CH-8093, Zurich, Switzerland.
Neri D; Philochem AG, CH-8112, Otelfingen, Switzerland. .; Institute of Pharmaceutical Sciences, ETH Zurich, CH-8093, Zurich, Switzerland. .; Philogen S.p.A, 53100, Siena, Italy. .
Dakhel Plaza S; Philochem AG, CH-8112, Otelfingen, Switzerland. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 06. Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Cell-mediated exon skipping normalizes dystrophin expression and muscle function in a new mouse model of Duchenne Muscular Dystrophy.
Autorzy:
Galli F; Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. .
Bragg L; Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Rossi M; Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Proietti D; Institue of Experimental Neurology, Division of Neurosciences. Ospedale San Raffaele Milan, Milan, Italy.
Perani L; Institue of Experimental Neurology, Division of Neurosciences. Ospedale San Raffaele Milan, Milan, Italy.
Bagicaluppi M; Institue of Experimental Neurology, Division of Neurosciences. Ospedale San Raffaele Milan, Milan, Italy.
Tonlorenzi R; Institue of Experimental Neurology, Division of Neurosciences. Ospedale San Raffaele Milan, Milan, Italy.
Sibanda T; Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Caffarini M; Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Talapatra A; Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Santoleri S; Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Meregalli M; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, 20122, Milan, Italy.
Bano-Otalora B; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Bigot A; Institut de Myologie, Université Pierre et Marie Curie, Paris 6 UM76, Univ. Paris 6/U974, UMR7215, CNRS, Pitié-Salpétrière-INSERM, UMRS 974, Paris, France.
Bozzoni I; Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00161, Rome, Italy.; Center for Life Nano- & (IIT), 00161, Rome, Italy.
Bonini C; Experimental Hematology Unit, Vita-Salute San Raffaele University, Milan, Italy.; IRCCS Ospedale San Raffaele Scientific Institute, 20133, Milan, Italy.
Mouly V; Institut de Myologie, Université Pierre et Marie Curie, Paris 6 UM76, Univ. Paris 6/U974, UMR7215, CNRS, Pitié-Salpétrière-INSERM, UMRS 974, Paris, France.
Torrente Y; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, 20122, Milan, Italy.
Cossu G; Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. .; Institue of Experimental Neurology, Division of Neurosciences. Ospedale San Raffaele Milan, Milan, Italy. .; Experimental and Clinical Research Center. Charité Medical Faculty and Max Delbrück Center 13125 Berlin, Berlin, Germany. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 04. Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
MET is a new confirmed gene responsible for familial distal arthrogryposis.
Autorzy:
Maffeo D; Medical Genetics, University of Siena, 53100, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100, Siena, Italy.
Carrer A; Medical Genetics, University of Siena, 53100, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100, Siena, Italy.; Genetica Medica, Azienda Ospedaliera universitaria Senese, 53100, Siena, Italy.
Rina A; Medical Genetics, University of Siena, 53100, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100, Siena, Italy.
Adamo L; Medical Genetics, University of Siena, 53100, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100, Siena, Italy.
Lo Rizzo C; Genetica Medica, Azienda Ospedaliera universitaria Senese, 53100, Siena, Italy.
Bruttini M; Medical Genetics, University of Siena, 53100, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100, Siena, Italy.; Genetica Medica, Azienda Ospedaliera universitaria Senese, 53100, Siena, Italy.
Renieri A; Medical Genetics, University of Siena, 53100, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100, Siena, Italy.; Genetica Medica, Azienda Ospedaliera universitaria Senese, 53100, Siena, Italy.
Mari F; Medical Genetics, University of Siena, 53100, Siena, Italy. .; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100, Siena, Italy. .; Genetica Medica, Azienda Ospedaliera universitaria Senese, 53100, Siena, Italy. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Mar 01. Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:
Letter
Opinia redakcyjna
Tytuł:
Improved gene therapy for spinal muscular atrophy in mice using codon-optimized hSMN1 transgene and hSMN1 gene-derived promotor.
Autorzy:
Xie Q; Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.; Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.
Chen X; Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.; Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.
Ma H; Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.; Viral Vector Core, UMass Chan Medical School, Worcester, MA, USA.
Zhu Y; CANbridge Pharmaceuticals, Burlington, MA, USA.
Ma Y; CANbridge Pharmaceuticals, Burlington, MA, USA.
Jalinous L; CANbridge Pharmaceuticals, Burlington, MA, USA.
Cox GF; CANbridge Pharmaceuticals, Burlington, MA, USA.
Weaver F; CANbridge Pharmaceuticals, Burlington, MA, USA.
Yang J; CANbridge Pharmaceuticals, Burlington, MA, USA.
Kennedy Z; CANbridge Pharmaceuticals, Burlington, MA, USA.
Gruntman A; Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.; Pediatrics, UMass Chan Medical School, Worcester, MA, USA.
Du A; Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.; Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.
Su Q; Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.; Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.; Viral Vector Core, UMass Chan Medical School, Worcester, MA, USA.
He R; Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.; Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.; Viral Vector Core, UMass Chan Medical School, Worcester, MA, USA.
Tai PW; Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.; Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.; Li Weibo Institute for Rare Diseases Research, UMass Chan Medical School, Worcester, MA, USA.
Gao G; Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA. .; Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA. .; Li Weibo Institute for Rare Diseases Research, UMass Chan Medical School, Worcester, MA, USA. .
Xie J; Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA. .; Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA. .; Viral Vector Core, UMass Chan Medical School, Worcester, MA, USA. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Feb 27. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Promoting expression in gene therapy: more is not always better.
Autorzy:
Zwartkruis MM; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Groen EJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Feb 27. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Stress granules-membraneless organelles as therapeutic targets in pancreatic cancer.
Autorzy:
Schneider C; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, 37075, Germany. .; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany. .
Schneider G; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, 37075, Germany. .; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany. .; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, 37075, Germany. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Feb 27. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
B cell lineage reconstitution underlies CAR-T cell therapeutic efficacy in patients with refractory myasthenia gravis.
Autorzy:
Tian DS; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, 430030, Wuhan, China.
Qin C; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, 430030, Wuhan, China.
Dong MH; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, 430030, Wuhan, China.
Heming M; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Zhou LQ; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, 430030, Wuhan, China.
Wang W; Nanjing IASO Biotechnology Co., Ltd, 210018, Nanjing, China.
Cai SB; Nanjing IASO Biotechnology Co., Ltd, 210018, Nanjing, China.
You YF; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, 430030, Wuhan, China.
Shang K; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, 430030, Wuhan, China.
Xiao J; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, 430030, Wuhan, China.
Wang D; Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
Li CR; Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
Zhang M; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, 430030, Wuhan, China.
Bu BT; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, 430030, Wuhan, China.
Meyer Zu Hörste G; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany. .
Wang W; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China. .; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, 430030, Wuhan, China. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Feb 26. Date of Electronic Publication: 2024 Feb 26.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases.
Autorzy:
Krauter D; Research Group 'Translational Neurogenetics', Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Stausberg D; Research Group 'Translational Neurogenetics', Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Hartmann TJ; Research Group 'Translational Neurogenetics', Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Volkmann S; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Kungl T; Institute of Anatomy, University of Leipzig, Leipzig, Germany.
Rasche DA; Research Group 'Translational Neurogenetics', Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Saher G; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Fledrich R; Institute of Anatomy, University of Leipzig, Leipzig, Germany.
Stassart RM; Institute of Neuropathology, University of Leipzig, Leipzig, Germany.
Nave KA; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Goebbels S; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. .
Ewers D; Research Group 'Translational Neurogenetics', Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. .; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. .; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany. .
Sereda MW; Research Group 'Translational Neurogenetics', Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. .; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. .; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Feb 21. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Rare coding variants in NOX4 link high ROS levels to psoriatic arthritis mutilans.
Autorzy:
Wang S; Division of Dermatology and Venereology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Nikamo P; Division of Dermatology and Venereology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Laasonen L; Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland.
Gudbjornsson B; Centre for Rheumatology Research, University Hospital and Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Ejstrup L; Department of Rheumatology, Odense University Hospital, Odense, Denmark.
Iversen L; Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Lindqvist U; Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden.
Alm JJ; Department of Microbiology, Tumor and Cell Biology & National Pandemic Center, Karolinska Institutet, Stockholm, Sweden.
Eisfeldt J; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Zheng X; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Catrina SB; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Center for Diabetes, Academic Specialist Center, Stockholm, Sweden.
Taylan F; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Vaz R; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Ståhle M; Division of Dermatology and Venereology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Dermatology and Venereology Clinic, Karolinska University Hospital, Stockholm, Sweden.
Tapia-Paez I; Division of Dermatology and Venereology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden. .
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2024 Feb 20. Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
Czasopismo naukowe

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