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Tytuł:
Role of CD93 in Health and Disease.
Autorzy:
Tossetta G; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126 Ancona, Italy.
Piani F; Cardiovascular Medicine Unit, Heart, Chest and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.; Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Borghi C; Cardiovascular Medicine Unit, Heart, Chest and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.; Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Marzioni D; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126 Ancona, Italy.
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Źródło:
Cells [Cells] 2023 Jul 04; Vol. 12 (13). Date of Electronic Publication: 2023 Jul 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Endothelial Cells*
Inflammation*
Humans ; Monocytes ; Neovascularization, Pathologic
Czasopismo naukowe
Tytuł:
Protective Effects of Cirsilineol against Lipopolysaccharide-Induced Inflammation; Insights into HO-1, COX-2, and iNOS Modulation.
Autorzy:
Kim GO; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea.
Park DH; Department of Ophthalmology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Republic of Korea.
Bae JS; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 10; Vol. 24 (10). Date of Electronic Publication: 2023 May 10.
Typ publikacji:
Journal Article
MeSH Terms:
Inflammation*/drug therapy
Flavones*/pharmacology
Animals ; Humans ; Mice ; Cyclooxygenase 2/metabolism ; Endothelial Cells/metabolism ; Heme Oxygenase-1/metabolism ; Lipopolysaccharides/toxicity ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism
Czasopismo naukowe
Tytuł:
Ataxin-10 Inhibits TNF- α -Induced Endothelial Inflammation via Suppressing Interferon Regulatory Factor-1.
Autorzy:
Li Y; Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Zhang Q; The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
Li N; School of Future Technology, Nanchang University, Nanchang, China.
Ding L; The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
Yi J; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Xiao Y; First School of Clinical Medicine, Nanchang University, Nanchang, China.
Chen S; Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Huang X; The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2021 Nov 23; Vol. 2021, pp. 7042148. Date of Electronic Publication: 2021 Nov 23 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Ataxin-10/*physiology
Endothelial Cells/*drug effects
Inflammation/*prevention & control
Interferon Regulatory Factor-1/*antagonists & inhibitors
Tumor Necrosis Factor-alpha/*pharmacology
Atherosclerosis/etiology ; Cells, Cultured ; Endothelial Cells/physiology ; Human Umbilical Vein Endothelial Cells ; Humans ; Monocytes/physiology ; NF-kappa B/physiology ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Vascular Cell Adhesion Molecule-1/analysis ; Vascular Cell Adhesion Molecule-1/genetics
Czasopismo naukowe
Tytuł:
Activation of the Complement System on Human Endothelial Cells by Urban Particulate Matter Triggers Inflammation-Related Protein Production.
Autorzy:
Choi MS; Department of Otorhinolaryngology, Eulji University Medical Center, Eulji University School of Medicine, Daejeon 35233, Korea.
Jeon H; Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 34824, Korea.
Yoo SM; Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 34824, Korea.
Lee MS; Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 34824, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 24; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 24.
Typ publikacji:
Journal Article
MeSH Terms:
Complement Activation*
Air Pollutants/*adverse effects
Complement System Proteins/*metabolism
Endothelial Cells/*metabolism
Inflammation/*metabolism
Blood Vessels/pathology ; Cell Death ; Cell Proliferation ; Cell Survival ; Cells, Cultured ; Cytokines/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Particulate Matter/adverse effects ; Phosphorylation ; Reactive Oxygen Species/metabolism ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł:
Single-Cell RNA Sequencing Reveals Heterogeneity and Functional Diversity of Lymphatic Endothelial Cells.
Autorzy:
den Braanker H; Department of Clinical Immunology and Rheumatology, Maasstad Hospital, Maasstadweg 21, 3079 DZ Rotterdam, The Netherlands.; Department of Rheumatology, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.; Department of Immunology, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
van Stigt AC; Department of Rheumatology, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.; Department of Immunology, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Kok MR; Department of Clinical Immunology and Rheumatology, Maasstad Hospital, Maasstadweg 21, 3079 DZ Rotterdam, The Netherlands.
Lubberts E; Department of Rheumatology, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.; Department of Immunology, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Bisoendial RJ; Department of Clinical Immunology and Rheumatology, Maasstad Hospital, Maasstadweg 21, 3079 DZ Rotterdam, The Netherlands.; Department of Immunology, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 05; Vol. 22 (21). Date of Electronic Publication: 2021 Nov 05.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Endothelial Cells/*physiology
Inflammation/*genetics
Lymph Nodes/*pathology
Animals ; Endothelial Cells/cytology ; Endothelial Cells/immunology ; Endothelial Cells/metabolism ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Lymph Nodes/immunology ; Lymph Nodes/metabolism ; Sequence Analysis, RNA/methods ; Single-Cell Analysis/methods
Czasopismo naukowe
Tytuł:
Argonaute-2 protects the neurovascular unit from damage caused by systemic inflammation.
Autorzy:
Machado-Pereira M; Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Rua Marquês d'Ávila e Bolama, 6201-001, Covilhã, Portugal.
Saraiva C; Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Rua Marquês d'Ávila e Bolama, 6201-001, Covilhã, Portugal.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7 Avenue des Hauts-Fourneaux, 4362, Esch-sur-Alzette, Luxembourg.
Bernardino L; Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Rua Marquês d'Ávila e Bolama, 6201-001, Covilhã, Portugal.
Cristóvão AC; Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Rua Marquês d'Ávila e Bolama, 6201-001, Covilhã, Portugal.; NeuroSoV, UBImedical, EM506, University of Beira Interior, Covilhã, Portugal.
Ferreira R; Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Rua Marquês d'Ávila e Bolama, 6201-001, Covilhã, Portugal. .; CEDOC, NOVA Medical School|Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056, Lisboa, Portugal. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2022 Jan 06; Vol. 19 (1), pp. 11. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Argonaute Proteins/*pharmacology
Astrocytes/*drug effects
Brain/*drug effects
Endothelial Cells/*drug effects
Inflammation/*metabolism
Microglia/*drug effects
Animals ; Argonaute Proteins/genetics ; Argonaute Proteins/metabolism ; Astrocytes/metabolism ; Brain/metabolism ; Endothelial Cells/metabolism ; Gene Silencing ; Lipopolysaccharides/pharmacology ; Mice ; Microglia/metabolism
Czasopismo naukowe
Tytuł:
Functional Roles for CD26/DPP4 in Mediating Inflammatory Responses of Pulmonary Vascular Endothelial Cells.
Autorzy:
Takahashi Y; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Kawasaki T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Sato H; Department of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Hasegawa Y; Department of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.
Dudek SM; Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Ohara O; Department of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.
Tatsumi K; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Suzuki T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
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Źródło:
Cells [Cells] 2021 Dec 11; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dipeptidyl Peptidase 4/*metabolism
Endothelial Cells/*enzymology
Inflammation/*pathology
Lung/*pathology
Cell Membrane Permeability/drug effects ; Endothelial Cells/drug effects ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Humans ; Inflammation/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Lipopolysaccharides/pharmacology ; RNA, Small Interfering/metabolism ; Reproducibility of Results ; Respiratory Distress Syndrome/genetics ; Transcriptome/drug effects ; Transcriptome/genetics
Czasopismo naukowe
Tytuł:
Uremic serum induces prothrombotic changes in venous endothelial cells and inflammatory changes in aortic endothelial cells.
Autorzy:
Sosińska-Zawierucha P; Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.
Bręborowicz A; Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.
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Źródło:
Renal failure [Ren Fail] 2021 Dec; Vol. 43 (1), pp. 401-405.
Typ publikacji:
Journal Article
MeSH Terms:
Arteries/*pathology
Endothelial Cells/*pathology
Endothelium, Vascular/*cytology
Inflammation/*pathology
Uremia/*metabolism
Cells, Cultured ; Endothelial Cells/metabolism ; Gene Expression Regulation ; Humans ; Inflammation/genetics ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/complications ; Tissue Plasminogen Activator/genetics ; Tissue Plasminogen Activator/metabolism ; Uremia/blood ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; von Willebrand Factor/genetics ; von Willebrand Factor/metabolism
Czasopismo naukowe
Tytuł:
Anti-Inflammatory Effects of C1q/Tumor Necrosis Factor-Related Protein 3 (CTRP3) in Endothelial Cells.
Autorzy:
Schmid A; Department of Internal Medicine III, University of Giessen, 35390 Giessen, Germany.
Vlacil AK; Department of Cardiology and Angiology, Philipps-University Marburg, 35037 Marburg, Germany.
Schuett J; Department of Cardiology and Angiology, Philipps-University Marburg, 35037 Marburg, Germany.
Karrasch T; Department of Internal Medicine III, University of Giessen, 35390 Giessen, Germany.
Schieffer B; Department of Cardiology and Angiology, Philipps-University Marburg, 35037 Marburg, Germany.
Schäffler A; Department of Internal Medicine III, University of Giessen, 35390 Giessen, Germany.
Grote K; Department of Cardiology and Angiology, Philipps-University Marburg, 35037 Marburg, Germany.
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Źródło:
Cells [Cells] 2021 Aug 20; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Profiling*
Adipokines/*immunology
Adipose Tissue/*immunology
Endothelial Cells/*immunology
Inflammation/*immunology
Adipokines/genetics ; Adipokines/metabolism ; Adipose Tissue/metabolism ; Animals ; Cell Adhesion/drug effects ; Cell Adhesion/genetics ; Cell Adhesion/immunology ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/immunology ; Cell Adhesion Molecules/metabolism ; Cell Line ; Cytokines/genetics ; Cytokines/immunology ; Cytokines/metabolism ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Lipopolysaccharides/pharmacology ; Male ; Mice, Inbred C57BL ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/immunology ; Toll-Like Receptor 4/metabolism ; Mice
Czasopismo naukowe
Tytuł:
Endoglin Is an Endothelial Housekeeper against Inflammation: Insight in ECFC-Related Permeability through LIMK/Cofilin Pathway.
Autorzy:
Rossi E; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.
Kauskot A; HITh, UMR-S 1176, INSERM-Faculty of Medicine, University Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France.
Saller F; HITh, UMR-S 1176, INSERM-Faculty of Medicine, University Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France.
Frezza E; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; CiTCoM, CNRS, Université de Paris, F-75006 Paris, France.
Poirault-Chassac S; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.
Lokajczyk A; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.
Bourdoncle P; Plate-Forme IMAG'IC Institut Cochin Inserm U1016-CNRS UMR8104, Université Paris Descartes, F-75006 Paris, France.
Saubaméa B; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; UMR-S 1144, F-75006 Paris, France.
Gaussem P; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.; AP-HP, Hematology Department, Hôpital Européen Georges Pompidou, F-75015 Paris, France.
Pericacho M; Department of Physiology and Pharmacology, Universidad de Salamanca, 37008 Salamanca, Spain.
Bobe R; HITh, UMR-S 1176, INSERM-Faculty of Medicine, University Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France.
Bachelot-Loza C; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.
Pasquali S; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; CiTCoM, CNRS, Université de Paris, F-75006 Paris, France.
Bernabeu C; Centro de Investigaciones Biológicas Margarita Salas, 28040 Madrid, Spain.; Consejo Superior de Investigaciones Científicas (CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 28040 Madrid, Spain.
Smadja DM; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.; AP-HP, Hematology Department, Hôpital Européen Georges Pompidou, F-75015 Paris, France.; Biosurgical Research Lab (Carpentier Foundation), F-75000 Paris, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 17; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 17.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Membrane Permeability*
Actin Depolymerizing Factors/*metabolism
Endoglin/*metabolism
Endothelial Cells/*pathology
Inflammation/*pathology
Lim Kinases/*metabolism
Neovascularization, Pathologic/*pathology
Actin Depolymerizing Factors/genetics ; Animals ; Endoglin/genetics ; Endothelial Cells/metabolism ; Inflammation/genetics ; Inflammation/metabolism ; Lim Kinases/genetics ; Mice ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/metabolism
Czasopismo naukowe
Tytuł:
Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling.
Autorzy:
Mirando AC; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Lima E Silva R; Department of Ophthalmology and the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Chu Z; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Campochiaro PA; Department of Ophthalmology and the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Pandey NB; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; AsclepiX Therapeutics, Inc., Baltimore, MD 21211, USA.
Popel AS; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 21; Vol. 21 (14). Date of Electronic Publication: 2020 Jul 21.
Typ publikacji:
Journal Article
MeSH Terms:
Angiopoietin-2/*metabolism
Collagen Type IV/*pharmacology
Endothelial Cells/*metabolism
Endothelium, Vascular/*drug effects
I-kappa B Kinase/*metabolism
Inflammation/*drug therapy
Peptide Fragments/*pharmacology
Receptor, TIE-2/*metabolism
Angiopoietin-1/metabolism ; Animals ; Capillary Permeability/drug effects ; Choroid Diseases/drug therapy ; Collagen Type IV/therapeutic use ; Endothelium, Vascular/cytology ; Endothelium, Vascular/immunology ; Endothelium, Vascular/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Intercellular Adhesion Molecule-1/metabolism ; Leukostasis/drug therapy ; Leukostasis/metabolism ; Mice ; Mice, Inbred C57BL ; Peptide Fragments/therapeutic use ; Receptor, TIE-2/agonists ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Receptors, Tumor Necrosis Factor, Type II/metabolism ; Retinal Diseases/drug therapy ; Signal Transduction/drug effects ; Tumor Necrosis Factor-alpha/pharmacology ; Vascular Cell Adhesion Molecule-1/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł:
Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate.
Autorzy:
Jeya Paul J; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, 07740 Jena, Germany.; Center for Molecular Biomedicine, Jena University Hospital, 07745 Jena, Germany.; Center for Sepsis Control and Care, Jena University Hospital, 07740 Jena, Germany.
Weigel C; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, 07740 Jena, Germany.; Center for Molecular Biomedicine, Jena University Hospital, 07745 Jena, Germany.; Leibniz Institute on Aging-Fritz Lipmann Institute, 07745 Jena, Germany.; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Müller T; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, 07740 Jena, Germany.; Center for Molecular Biomedicine, Jena University Hospital, 07745 Jena, Germany.
Heller R; Center for Molecular Biomedicine, Jena University Hospital, 07745 Jena, Germany.; Center for Sepsis Control and Care, Jena University Hospital, 07740 Jena, Germany.; Institute of Molecular Cell Biology, Jena University Hospital, 07745 Jena, Germany.
Spiegel S; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Gräler MH; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, 07740 Jena, Germany.; Center for Molecular Biomedicine, Jena University Hospital, 07745 Jena, Germany.; Center for Sepsis Control and Care, Jena University Hospital, 07740 Jena, Germany.
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Źródło:
Cells [Cells] 2020 Apr 10; Vol. 9 (4). Date of Electronic Publication: 2020 Apr 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelial Cells/*metabolism
Inflammation/*metabolism
Lysophospholipids/*metabolism
Sphingosine/*analogs & derivatives
Animals ; Cell Line, Tumor ; Cells, Cultured ; Endothelial Cells/pathology ; Human Umbilical Vein Endothelial Cells ; Humans ; Inflammation/pathology ; Membrane Proteins/metabolism ; Mice ; Rats ; Signal Transduction ; Sphingosine/metabolism ; Sphingosine-1-Phosphate Receptors/metabolism
Czasopismo naukowe
Tytuł:
Isoflavone-mediated radioprotection involves regulation of early endothelial cell death and inflammatory signaling in Radiation-Induced lung injury.
Autorzy:
Fountain MD; Department of Biochemistry, Microbiology & Immunology, Wayne State University School of Medicine, Detroit, MI, USA.; Department of Oncology, Division of Radiation Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, MI, USA.
McLellan LA; Department of Biochemistry, Microbiology & Immunology, Wayne State University School of Medicine, Detroit, MI, USA.
Smith NL; Department of Biochemistry, Microbiology & Immunology, Wayne State University School of Medicine, Detroit, MI, USA.
Loughery BF; Department of Oncology, Division of Radiation Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, MI, USA.
Rakowski JT; Department of Oncology, Division of Radiation Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, MI, USA.
Tse HY; Department of Biochemistry, Microbiology & Immunology, Wayne State University School of Medicine, Detroit, MI, USA.
Hillman GG; Department of Biochemistry, Microbiology & Immunology, Wayne State University School of Medicine, Detroit, MI, USA.; Department of Oncology, Division of Radiation Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, MI, USA.
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Źródło:
International journal of radiation biology [Int J Radiat Biol] 2020 Feb; Vol. 96 (2), pp. 245-256. Date of Electronic Publication: 2019 Nov 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelial Cells/*radiation effects
Inflammation/*prevention & control
Isoflavones/*pharmacology
Radiation Pneumonitis/*prevention & control
Radiation-Protective Agents/*pharmacology
Animals ; Female ; Human Umbilical Vein Endothelial Cells ; Humans ; Lung/radiation effects ; Mice ; Mice, Inbred C57BL ; Pulmonary Fibrosis/prevention & control ; Radiation Protection/methods ; Signal Transduction
Czasopismo naukowe
Tytuł:
Epsins Negatively Regulate Aortic Endothelial Cell Function by Augmenting Inflammatory Signaling.
Autorzy:
Dong Y; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Wang B; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cui K; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cai X; Cardiovascular Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Bhattacharjee S; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Wong S; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cowan DB; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Chen H; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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Źródło:
Cells [Cells] 2021 Jul 29; Vol. 10 (8). Date of Electronic Publication: 2021 Jul 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Inflammation*
Signal Transduction*
Adaptor Proteins, Vesicular Transport/*metabolism
Atherosclerosis/*metabolism
Endothelial Cells/*metabolism
Animals ; Aorta/metabolism ; Atherosclerosis/etiology ; Endothelial Cells/pathology ; Female ; Lipoproteins, LDL/metabolism ; Male ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł:
Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species.
Autorzy:
Li X; Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Römer G; Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Department of Anesthesiology and Intensive Care Medicine, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Kerindongo RP; Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Hermanides J; Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Albrecht M; Department of Anesthesiology and Intensive Care Medicine, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Hollmann MW; Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Zuurbier CJ; Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Preckel B; Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Weber NC; Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 03; Vol. 22 (11). Date of Electronic Publication: 2021 Jun 03.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells/*drug effects
Inflammation/*drug therapy
Oxidative Stress/*drug effects
Sodium-Glucose Transport Proteins/*antagonists & inhibitors
Sodium-Hydrogen Exchanger 1/*antagonists & inhibitors
Benzhydryl Compounds/pharmacology ; Canagliflozin/pharmacology ; Cell Membrane Permeability/drug effects ; Endothelial Cells/metabolism ; Glucosides/pharmacology ; Guanidines/pharmacology ; Humans ; Inflammation/genetics ; Inflammation/pathology ; NADPH Oxidases/antagonists & inhibitors ; NADPH Oxidases/genetics ; Oxidative Stress/genetics ; Pyrazoles/pharmacology ; Pyridones/pharmacology ; Reactive Oxygen Species/metabolism ; Sodium-Glucose Transport Proteins/genetics ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Hydrogen Exchanger 1/genetics ; Stress, Mechanical ; Sulfones/pharmacology
Czasopismo naukowe
Tytuł:
Effect of TNFα stimulation on expression of kidney risk inflammatory proteins in human umbilical vein endothelial cells cultured in hyperglycemia.
Autorzy:
Md Dom ZI; Research Division, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Pipino C; Research Division, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology, University G. D'Annunzio of Chieti-Pescara, Chieti, Italy.
Krolewski B; Research Division, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
O'Neil K; Research Division, Joslin Diabetes Center, Boston, MA, USA.
Satake E; Research Division, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Krolewski AS; Research Division, Joslin Diabetes Center, Boston, MA, USA. .; Department of Medicine, Harvard Medical School, Boston, MA, USA. .; Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA, 02215, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 May 27; Vol. 11 (1), pp. 11133. Date of Electronic Publication: 2021 May 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Human Umbilical Vein Endothelial Cells/*drug effects
Hyperglycemia/*metabolism
Inflammation/*metabolism
Receptors, Tumor Necrosis Factor/*metabolism
Tumor Necrosis Factor-alpha/*pharmacology
Down-Regulation/drug effects ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł:
Carotenoids Inhibit Fructose-Induced Inflammatory Response in Human Endothelial Cells and Monocytes.
Autorzy:
Lin P; Department of Geriatric, The 3rd Hospital of Hangzhou, Zhejiang 310009, China.
Ren Q; Department of Geriatric, The 3rd Hospital of Hangzhou, Zhejiang 310009, China.
Wang Q; Department of Geriatric, The 3rd Hospital of Hangzhou, Zhejiang 310009, China.
Wu J; Department of Geriatric, The 3rd Hospital of Hangzhou, Zhejiang 310009, China.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2020 Apr 28; Vol. 2020, pp. 5373562. Date of Electronic Publication: 2020 Apr 28 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Atherosclerosis/*metabolism
Carotenoids/*metabolism
Endothelial Cells/*metabolism
Fructose/*chemistry
Inflammation/*metabolism
Monocytes/*metabolism
Beta-Cryptoxanthin/pharmacology ; Carotenoids/pharmacology ; Cell Adhesion ; Cytokines/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Lipid Peroxidation ; Lutein/pharmacology ; Lycopene/pharmacology ; Monocytes/cytology ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; U937 Cells
Czasopismo naukowe
Tytuł:
GPR40 Agonism Modulates Inflammatory Reactions in Vascular Endothelial Cells.
Autorzy:
Kim JW; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea.
Roh E; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Choi KM; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Yoo HJ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Hwang HJ; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea.
Baik SH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
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Źródło:
Diabetes & metabolism journal [Diabetes Metab J] 2022 May; Vol. 46 (3), pp. 506-511. Date of Electronic Publication: 2022 Jan 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Inflammation*/metabolism
Receptors, G-Protein-Coupled*/agonists
Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Intercellular Adhesion Molecule-1 ; Lipopolysaccharides ; NF-kappa B/metabolism ; THP-1 Cells ; Vascular Cell Adhesion Molecule-1/metabolism
Czasopismo naukowe
Tytuł:
Genistein alleviates chronic vascular inflammatory response via the miR‑21/NF‑κB p65 axis in lipopolysaccharide‑treated mice.
Autorzy:
Xie X; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Hunan Normal University, Changsha, Hunan 410013, P.R. China.
Cong L; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Hunan Normal University, Changsha, Hunan 410013, P.R. China.
Liu S; Department of Basic Medicine, School of Medicine, Hunan Normal University, Changsha, Hunan 410013, P.R. China.
Xiang L; Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Fu X; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Hunan Normal University, Changsha, Hunan 410013, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Mar; Vol. 23 (3). Date of Electronic Publication: 2021 Jan 26.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells/*metabolism
Genistein/*pharmacology
Inflammation/*metabolism
Lipopolysaccharides/*toxicity
MicroRNAs/*metabolism
Signal Transduction/*drug effects
Transcription Factor RelA/*metabolism
Vasculitis/*metabolism
Animals ; Chronic Disease ; Endothelial Cells/pathology ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/genetics ; Male ; Mice ; MicroRNAs/genetics ; Transcription Factor RelA/genetics ; Vasculitis/chemically induced ; Vasculitis/drug therapy ; Vasculitis/genetics
Czasopismo naukowe
Tytuł:
Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus.
Autorzy:
Jansson D; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.; Department of Psychiatry and Behavioural Science, University of Washington, Seattle, WA, USA.
Dieriks VB; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, The University of Auckland, Auckland, New Zealand.
Rustenhoven J; Center for Brain Immunology and Glia (BIG), Washington University, St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St. Louis, MO, USA.
Smyth LCD; Department of Pathology, University of Otago, Christchurch, New Zealand.; Centre for Free Radical Research, University of Otago, Christchurch, New Zealand.
Scotter E; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.
Aalderink M; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.
Feng S; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.
Johnson R; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.
Schweder P; Department of Neurosurgery, Auckland City Hospital, Auckland, New Zealand.
Mee E; Department of Neurosurgery, Auckland City Hospital, Auckland, New Zealand.
Heppner P; Starship Hospital, Auckland, New Zealand.
Turner C; Department of Anatomical Pathology, LabPlus, Auckland City Hospital, Auckland, New Zealand.
Curtis M; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, The University of Auckland, Auckland, New Zealand.
Faull R; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, The University of Auckland, Auckland, New Zealand.
Dragunow M; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand. .; Centre for Brain Research, The University of Auckland, Auckland, New Zealand. .
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Źródło:
Communications biology [Commun Biol] 2021 Feb 26; Vol. 4 (1), pp. 260. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Inflammatory Agents/*pharmacology
Blood-Brain Barrier/*drug effects
Choroid Plexus/*drug effects
Digoxin/*pharmacology
Endothelial Cells/*drug effects
Inflammation/*drug therapy
Lanatosides/*pharmacology
Meninges/*drug effects
Pericytes/*drug effects
Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Cells, Cultured ; Choroid Plexus/metabolism ; Choroid Plexus/pathology ; Drug Evaluation, Preclinical ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; High-Throughput Screening Assays ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Meninges/metabolism ; Meninges/pathology ; Pericytes/metabolism ; Pericytes/pathology ; Tissue Culture Techniques
Czasopismo naukowe

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